作者： Binqiang Xu  ¹, Yang Fu  ², Nuoming Yin  ², Wenfei Qin  ³, Zehua Huang  ², Wei Xiao  ³, Huizhen Huang  ⁴, Qixiang Mei  ², Junjie Fan  ⁵, Yue Zeng  ⁵, Chunlan Huang  ⁵ （Affiliations ¹ Department of Gastroenterology, Shanghai Key Laboratory of Pancreatic Diseases, Shanghai JiaoTong University School of Medicine, Shanghai, China. ² Shanghai Key Laboratory of Pancreatic Disease, Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China. ³ Department of Gastroenterology, University of Shanghai for Science and Technology, Shanghai, China. ⁴ Department of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. ⁵ Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.）

出处： American journal of physiology. Gastrointestinal and liver physiology 2024

关键词： Bacteroides thetaiotaomicron;Faecalibacterium prausnitzii;fecal microbiota transplantation;gut microbiota;inflammatory bowel disease.

摘要： Fecal microbiota transplantation (FMT) is a promising therapy for inflammatory bowel disease (IBD) via rectifying gut microbiota. The aim of this stud ...

作者： Enjun He ^{#  1}, Haitao Sui ^{#  2}, Hongjie Wang ^{#  1}, Xiang Zhao  ³, Weihong Guo  ¹, Zhicheng Dai  ¹, Zhenkai Wu  ⁴, Kai Huang  ⁵, Qinghua Zhao  ⁶ （Affiliations ¹ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Orthopaedics, Dongying People's Hospital, Dongying, Shandong, China. ³ Department of Surgery of Spine and Spinal Cord, People's Hospital of Henan University, Henan Provincial People's Hospital, Henan, Zhengzhou, China. ⁴ Department of Pediatric Orthopaedics, Shanghai Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Orthopedics, Zhabei Central Hospital of Jing'an District, Shanghai, China. 13817784210@163.com. ⁶ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. qinghua.zhao@shgh.cn.）

出处： Stem cell reviews and reports 2024

关键词： Aging;BMSCs;IL-19;Osteoporosis;sFRP1.

摘要： Background: Cellular senescence is an important process related to the pathogenic mechanism of different disorders, especially bone loss. During senes ...

作者： De-Wei An  ^{1   2   3}, Yu-Ling Yu  ^{2   3}, Azusa Hara  ⁴, Dries S Martens  ⁵, Wen-Yi Yang  ⁶, Yi-Bang Cheng  ¹, Qi-Fang Huang  ¹, Kei Asayama  ^{2   7}, Katarzyna Stolarz-Skrzypek  ⁸, Marek Rajzer  ⁸, Peter Verhamme  ⁹, Tim S Nawrot  ^{3   5}, Yan Li  ¹, Jan A Staessen  ^{1   2   10} （Affiliations ¹ Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. ² Non-Profit Research Association Alliance for the Promotion of Preventive Medicine. ³ Research Unit Environment and Health, KU Leuven Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium. ⁴ Division of Drug Development and Regulatory Science, Faculty of Pharmacy, Keio University, Japan. ⁵ Center for Environmental Sciences, Hasselt University, Hasselt, Belgium. ⁶ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan. ⁸ First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University, Kraków, Poland. ⁹ Center for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences. ¹⁰ Biomedical Sciences Group, Faculty of Medicine, University of Leuven, Leuven, Belgium.）

出处： Journal of hypertension 2024

摘要： Objectives: We undertook time-stratified analyses of the National Health and Nutrition Examination Survey in the US to assess time trends (1999-2020) ...

作者： Yan Hu  ¹, Xiaoqun Li  ², Xiao Chen  ¹, Sicheng Wang  ³, Liehu Cao  ⁴, Hao Zhang  ¹, Yunfei Zhang  ⁵, Zhiwei Wang  ⁶, Baoqing Yu  ⁷, Peijian Tong  ⁸, Qiang Zhou  ⁹, Feng Niu  ¹⁰, Weiguo Yang  ¹¹, Wencai Zhang  ¹², Shijie Chen  ¹³, Qiang Yang  ¹⁴, Tao Shen  ¹⁵, Peng Zhang  ¹⁶, Yong Zhang  ⁵, Jun Miao  ¹⁴, Haodong Lin  ¹⁷, Jinwu Wang  ¹⁸, Lei Wang  ¹⁹, Xin Ma  ²⁰, Hongjian Liu  ²¹, Ilia Stambler  ^{22   23}, Long Bai  ²⁴, Han Liu  ²⁴, Yingying Jing  ²⁴, Guohui Liu  ²⁵, Xinglong Wang  ²⁶, Dongliang Wang  ¹, Zhongmin Shi  ²⁰, Robert Chunhua Zhao  ^{23   27}, Jiacan Su  ^{1   24} （Affiliations ¹ Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ² First Affiliated Hospital of Naval Medical University, Shanghai, China. ³ Shanghai Zhongye Hospital, Shanghai, China. ⁴ Luodian Hospital, Baoshan District, Shanghai, China. ⁵ Tangdu Hospital Air Force Medical University, Xi'an, China. ⁶ Eastern Hepatobiliary Surgery Hospital, Shanghai, China. ⁷ Shanghai Pudong New Area People's Hospital, Shanghai, China. ⁸ Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou, China. ⁹ Third Affiliated Hospital of Chongqing Medical University, Chongqing, China. ¹⁰ First Bethune Hospital of Jilin University, Changchun, China. ¹¹ HKU Li Ka Shing Faculty of Medicine, Hongkong, China. ¹² First Affiliated Hospital of Jinan University, Guangzhou, China. ¹³ Third Xiangya Hospital of Central South University, Changsha, China. ¹⁴ Tianjin Hospital, Tianjin, China. ¹⁵ Shengjing Hospital of Chinese Medical University, Shenyang, China. ¹⁶ Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. ¹⁷ Shanghai General Hospital, Shanghai, China. ¹⁸ Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁹ Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China. ²⁰ Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China. ²¹ First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ²² Department of Science, Technology and Society, Bar Ilan University, Ramat Gan, Israel. ²³ International Society on Aging and Disease, Bryan, TX, USA. ²⁴ Institute of Translational Medicine, Shanghai University, Shanghai, China. ²⁵ Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ²⁶ Department of Pharmacology & Toxicology, University of Arizona, Tucson, USA. ²⁷ Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.）

出处： Aging and disease 2024

摘要： Osteoporotic fractures are the most severe complications of osteoporosis, characterized by poor bone quality, difficult realignment and fixation, slow ...

作者： Ming Tong  ¹, Yun Bai  ², Jiao Lyu  ³, Ling Ren  ¹, Linyu Zhang  ^{4   5}, Mudi Yao  ¹, Xiaoyan Han  ¹, Xiumiao Li  ^{4   5}, Dan Li  ¹, Pei-Quan Zhao  ³, Qin Jiang  ^{4   5}, Biao Yan  ^{1   6} （Affiliations ¹ Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China. ² College of Information Science, Shanghai Ocean University, Shanghai, China. ³ Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. ⁴ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China. ⁵ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Clinical and translational medicine 2024

作者： Ming Tong  ¹, Yun Bai  ², Xiaoyan Han  ¹, Lingjie Kong  ¹, Ling Ren  ¹, Linyu Zhang  ³, Xiumiao Li  ⁴, Jin Yao  ⁵, Yan Biao  ⁶ （Affiliations ¹ Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, 200031, China. ² College of Information Science, Shanghai Ocean University, Shanghai, 201306, China. ³ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China; The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. ⁴ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. ⁵ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China; The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. Electronic address: jinyao1972@126.com. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: biao.yan@fdeent.org.）

出处： Experimental eye research 2024

关键词： Age-related macular degeneration;Choroidal neovascularization;Endothelial heterogeneity;Single-cell sequencing.

摘要： Choroidal neovascularization (CNV) is a hallmark of neovascular age-related macular degeneration (nAMD) and a major contributor to vision loss in nAMD ...

作者： Xiaoye Shi ^{#  1   2}, Gengwen Deng ^{#  1   3}, Haiteng Wen  ^{1   2}, Anqi Lin  ¹, Haitao Wang  ⁴, Lingxuan Zhu  ^{1   5}, Weiming Mou  ^{1   6}, Zaoqu Liu  ^{7   8}, Xiaohua Li  ⁹, Jian Zhang  ¹, Quan Cheng  ^{10   11}, Peng Luo  ¹ （Affiliations ¹ Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. ² The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. ³ The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. ⁴ Thoracic Surgery Branch, Centre for Cancer Research, National Institutes of Health, Bethesda, Maryland, USA. ⁵ Department of Aetiology and Carcinogenesis, National Cancer Centre, National Clinical Research Centre for Cancer, Cancer Hospital, Changping Laboratory, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ⁶ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Key Laboratory of Proteomics, Beijing Proteome Research Centre, National Centre for Protein Sciences, Beijing Institute of Lifeomics, Beijing, China. ⁸ Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, China. ⁹ Department of Respiratory and Critical Care Medicine, Sixth People's Hospital of Chengdu, Chengdu, Sichuan, China. ¹⁰ Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. ¹¹ National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China.）

出处： Journal of global health 2024

摘要： Background: This study was designed to evaluate the effects of body mass index (BMI) and weight change on the risk of developing cancer overall and ca ...

作者： Chuanjiang Jian  ¹, Minjia Wang  ¹, Yunyun Qian  ², Xuejiao Song  ¹, Li Wang  ³, Ling Li  ¹, Lulu Huang  ⁴, Guan Wang  ⁵, Xianjie Shi  ¹, Jinqiao Dong  ⁶, Hao Li  ², Ang Lin  ⁴, Leilei Shi  ³ （Affiliations ¹ The Eighth Affiliated Hospital Sun Yat-sen University, 3025 Shennan Middle Road, Shenzhen, 518000, China. ² Department of Organ Transplantation, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361005, China. ³ Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ⁴ Vaccine Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China. ⁵ Department of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning, 116044, China. ⁶ School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, 200240, China.）

出处： Advanced healthcare materials 2024

关键词： TLR4;active peptide hydrogel;anti‐inflammatory;diabetic wound healing;macrophages polarization.

摘要： Persistent inflammation and disrupted immunoregulation are critical factors in impeding diabetic wound healing. While immunoregulatory hydrogel dressi ...

作者： Mo Cheng  ¹, Qingjie Kong  ², Qing Tian  ³, Weiluo Cai  ¹, Chunmeng Wang  ¹, Minjia Yuan  ^{4   5}, Wenxing Wang  ⁶, Peiyuan Wang  ⁷, Wangjun Yan  ⁸ （Affiliations ¹ Department of Musculoskeletal Surgery of Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China. ² Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P. R. China. ³ Department of Neurology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, 201799, P. R. China. ⁴ Department of Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, P. R. China. ⁵ Shanghai Qiran Biotechnology Co., Ltd, Shanghai, 201702, China. ⁶ Department of Chemistry, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Fudan University, Shanghai, 200433, P. R. China. wangwenxing@fudan.edu.cn. ⁷ Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, P. R. China. wangpeiyuan@fjirsm.ac.cn. ⁸ Department of Musculoskeletal Surgery of Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China. yanwj@fudan.edu.cn.）

出处： Journal of nanobiotechnology 2024

摘要： Background: As the lethal bone tumor, osteosarcoma often frequently occurs in children and adolescents with locally destructive and high metastasis. D ...

作者： Zhen Peng ^{#  1}, Beijie Qi ^{#  2   3}, Zhiwen Luo ^{#  4}, Yaying Sun  ¹, Xingyu Zhang  ¹, Jinrong Lin  ⁴, Jinhui Pang  ¹, Peng Zhang  ⁴, Zhihu Zhao  ⁵, Xianwen Wang  ⁶, Jiwu Chen  ⁷ （Affiliations ¹ Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiaotong University, 85# Wujin Road, Hongkou District, Shanghai, 200080, China. ² Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China. ³ Shanghai Medicine College, Fudan University, Shanghai, 201399, China. ⁴ Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, 200080, China. ⁵ Department of Orthopaedics, Tianjin Hospital, No. 406, Jiefangnan Road, Hexi District, Tianjin, 300000, China. gukezzh@126.com. ⁶ School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, 230032, China. xianwenwang@ahmu.edu.cn. ⁷ Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiaotong University, 85# Wujin Road, Hongkou District, Shanghai, 200080, China. jeevechen@gmail.com.）

出处： Journal of nanobiotechnology 2024

关键词： Cell membrane;Fibrosis;Frozen shoulder;Nanoparticle;microRNA.

摘要： As a common musculoskeletal disorder, frozen shoulder is characterized by thickened joint capsule and limited range of motion, affecting 2-5% of the g ...