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作者: Xinran Qin  1, Haidong Zou  2   3   4   5   6 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zouhaidong@sjtu.edu.cn. 3 Shanghai Eye Diseases Prevention & Treatment Center, Shanghai Eye Hospital, Shanghai, China. zouhaidong@sjtu.edu.cn. 4 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 5 National Clinical Research Center for Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 6 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn.)

出处: BMC ophthalmology 2022 Vol.22 No.1 P86

关键词: Blood-retina barrier;Diabetic retinopathy;Dysbiosis;Gut leakage;Inflammation;Lipopolysaccharides;Retinal glia.

摘要: Diabetes mellitus (DM) is a complex metabolic syndrome characterized by hyperglycemia. Diabetic retinopathy (DR) is the most common complication of DM ...

[外文期刊] Elevated mid-trimester 4-h postprandial triglycerides for predicting late-onset preeclampsia: a prospective screening study
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作者: Qing Liu #  1, Zhihong Zhu #  2, Wen Cai  3, Liu Yang  2, ShuangDi Li  4, Jiarong Zhang  5   6 (Affiliations 1 Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, 2699 Gaoke West Road, Shanghai, China. 2 Department of Obstetrics and Gynecology, Shanghai ZhongShan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China. 3 Department of Obstetrics and Gynecology, ShangHai General Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, China. 4 Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, 2699 Gaoke West Road, Shanghai, China. lishuangdi21@126.com. 5 Department of Obstetrics and Gynecology, Shanghai ZhongShan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China. maggie1974@126.com. 6 Department of Obstetrics and Gynecology, ShangHai General Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, China. maggie1974@126.com.)

出处: Journal of translational medicine 2022 Vol.20 No.1 P81

关键词: Hypertriglyceridemia;Metabolism;OLTT;Prediction;Preeclampsia.

摘要: Background: Abnormal maternal lipid concentrations are associated with increased risk of preeclampsia. However, previous studies mainly focused on fas ...

[外文期刊] CtBP2 interacts with TGIF to promote the progression of esophageal squamous cell cancer through the Wnt/β‑catenin pathway
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作者: Qianqian Ju  1, Maorong Jiang  2, Wenxin Huang  3, Qingbo Yang  4, Zhenghong Luo  4, Hui Shi  1 (Affiliations 1 School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China. 2 Key Laboratory for Neuroregeneration, Medical College of Nantong University, Nantong, Jiangsu 226001, P.R. China. 3 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China. 4 Department of Thoracic Surgery, Shanghai Tenth People\'s Hospital, Shanghai 200072, P.R. China.)

出处: Oncology reports 2022 Vol.47 No.2 P29

关键词: CtBP2;TGIF;Wnt/β‑catenin;esophageal squamous cell carcinoma;invasion;migration;proliferation.

摘要: C‑terminal‑binding protein 2 (CtBP2), a transcriptional co‑repressor, plays a main role in tumorigenesis and in the development of multiple tumors. Tr ...

[外文期刊] New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis
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作者: Yanting Che  1   2   3, Jingzhi Yang  2, Fen Tang  3, Ziheng Wei  4, Yufan Chao  3, Na Li  3, Henghui Li  2, Si Wu  5, Xin Dong  2   3 (Affiliations 1 College of Sciences, Shanghai University, Shanghai 200444, China. 2 Institute of Translational Medicine, Shanghai University, Shanghai 200444, China. 3 School of Medicine, Shanghai University, Shanghai 200444, China. 4 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. 5 Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.)

出处: International journal of molecular sciences 2022 Vol.23 No.4 P2020

关键词: 20S-hydroxycholesterol (20S-HC);22S-hydroxycholesterol (22S-HC);27-hydroxycholesterol (27-HC);cholesterol oxidation products (COPs);osteoporosis (OP).

摘要: Osteoporosis (OP) is a systemic bone disease characterized by decreased bone strength, microarchitectural changes in bone tissues, and increased risk ...

[外文期刊] Development and validation of a radiomics nomogram to discriminate advanced pancreatic cancer with liver metastases or other metastatic patterns.
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作者: Zhang, Tianliang1;Dong, Xiao1,2;Zhou, Yang3;Liu, Muhan3;Hang, Junjie3;Wu, Lixia4 (1 School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China 2 Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 3 Changzhou No. 2 People\'s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, China 4 Department of Oncology, Shanghai JingAn District ZhaBei Central Hospital, Shanghai, China)

出处: Cancer Biomarkers 2022 Vol.32 No.4 P541-550

关键词: Liver metastases;metastatic patterns;pancreatic cancer;radiomics nomogram;texture features

摘要: BACKGROUND: Patients with advanced pancreatic cancer (APC) and liver metastases have much poorer prognoses than patients with other metastatic pattern ...

[外文期刊] GIPR rs10423928 and bone mineral density in postmenopausal women in Shanghai
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作者: Lizhi Zhang  1   2, Jinwei He  3, Xiang Sun  4, Dongyue Pang  1, Jingjing Hu  1, Bo Feng  2 (Affiliations 1 Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. 2 Department of Endocrinology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People\'s Hospital, Shanghai, China. 4 Shanghai Institute of Technology, Shanghai, China.)

出处: Endocrine connections 2022 Vol.11 No.2

关键词: bone mineral density;glucose-dependent insulinotropic peptide;haplotype;osteoporosis;polymorphism;single-nucleotide polymorphism.

摘要: We demonstrated previously that there is a correlation between glucagon-like peptide-1 (GLP-1) single-nucleotide polymorphism (SNP) and bone mineral d ...

作者: Yiwen Zhang  1, Haoyu You  1, Yaoben Wang  2, Qinjun Chen  1, Qin Guo  1, Yongchao Chu  1, Chao Li  1, Wenxi Zhou  1, Hongyi Chen  1, Peixin Liu  1, Yu Wang  1, Zhenhao Zhao  1, Zheng Zhou  1, Yifan Luo  1, Xuwen Li  1, Tongyu Zhang  1, Haolin Song  1, Chufeng Li  1, Boyu Su  1, Tao Sun  1, Yunke Bi  3, Lin Yu  2, Chen Jiang  1 (Affiliations 1 Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, China. 2 State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China. 3 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201203, China.)

出处: Advanced healthcare materials 2022 Vol.11 No.3 Pe2101578

关键词: drug delivery;glioblastoma;injectable hydrogels;microenvironments;post-operative therapy.

摘要: The rapid postoperative recurrence and short survival time of glioblastoma (GBM) patients necessitate immediate and effective postoperative treatment. ...

作者: Yuhong Chen  1   2, Xinyue Zhu  1   2, Fuxiang Ye  1   2, Hong Wang  1   2, Xiaoling Wan  1   2   3, Ting Zhang  1   2   3, Yuwei Wang  1   2, Yimin Wang  1   2, Xiaohuan Zhao  1   2, Xinyue Bai  1   2, Yushu Xiao  1   2, Xiaodong Sun  1   2   3   4 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. 2 National Clinical Research Center for Eye Diseases, Shanghai, China. 3 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. 4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.)

出处: Translational vision science & technology 2022 Vol.11 No.1 P12

摘要: Purpose: This study aimed to establish a novel choroidal neovascularization (CNV) mouse model through subretinally injecting malondialdehyde (MDA)-mod ...

作者: Min Zhou  1, Wan Zhang  2, Yucheng Zhang  3, Tianchen Xie  1, Jieqi Mao  4, Zhenyu Shi  5 (Affiliations 1 Department of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai, China. 2 Department of Vascular Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China. 3 Department of Vascular Surgery, Wusong Branch, Zhongshan Hospital, Fudan University, Shanghai, China. 4 Department of Vascular Surgery, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. 5 Department of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai, China shizhenyumax@163.com.)

出处: BMJ open 2022 Vol.12 No.2 Pe056826

关键词: anticoagulation;thromboembolism;vascular surgery.

摘要: Introduction: The efficacy and safety of anticoagulant treatment is not established for patients with acute symptomatic isolated distal deep vein thro ...

作者: Di Mu1;Yan-Gang Sun2,3CA1 (1 Department of Anesthesiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; 2 Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Sciences, Shanghai, China; 3 Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China)

出处: Journal of Investigative Dermatology 2022 Vol.142 No.1 P23-30

摘要: Itch is an unpleasant somatic sensation with the desire to scratch, and it consists of sensory, affective, and motivational components. Acute itch ser ...

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