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作者: Desheng Chen;|Qi Zhu;|Tiewen Li;|Xuhui Fan;|Yichao Lou;|Yi Zhang;|Kejie Huang;|Hongcheng Sun (Affiliations 1 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Institution for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 College of Information Science Electronic Engineering, Zhejiang University, Hangzhou, China.)

出处: Frontiers in genetics 2023

关键词: KLF4;biomarker;hepatocellular carcinoma;immune microenvironment;prognosis.

摘要: Introduction: Although the molecular mechanisms of Krüpple-like factor 4 (KLF4) as a tumor suppressor in HCC tumorigenesis have been thoroughly examin ...

作者: Yahui Zhang;|Yi Lin;|Guoqiang Li;|Yuan Yuan;|Xuejiao Wang;|Na Li;|Chuanhao Xiong;|Yueying Yang;|Yuhang Ma;|Zhijian Zhang;|Xiaoying Ding (Affiliations 1 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. 3 Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Biology of reproduction 2023

关键词: Browning;GLP-1 receptor agonists (GLP-1RAs);Hyperandrogenemia;Hyperinsulinemia;Inflammation;Polycystic ovary syndrome (PCOS).

摘要: Polycystic ovary syndrome (PCOS) is a complicated hormonal and metabolic disorder with hyperandrogenemia, insulin resistance and reproductive dysfunct ...

作者: Kaidi Xiang;Jun Chen;Wenchen Zhao;Zhuoting Zhu;Li Ding;Gabriella Bulloch;Linlin Du;Xun Xu;Mengjun Zhu;Xiangui He (Affiliations 1 Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Jiao Tong University, Shanghai, China. 3 Ophthalmology, Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.)

出处: Acta ophthalmologica 2023

摘要: Purpose: To determine how orthokeratology (ortho-k) affects corneal biomechanical properties in myopia control and whether corneal biomechanical param ...

作者: Yuwei Wang;Yuhong Chen;Jian Liang;Mei Jiang;Ting Zhang;Xiaoling Wan;Jiahui Wu;Xiaomeng Li;Jieqiong Chen;Junran Sun;Yifan Hu;Peirong Huang;Jingyang Feng;Te Liu;Xiaodong Sun (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 2 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China. 3 Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, China. 4 National Clinical Research Center for Eye Diseases, Shanghai 200080, China. 5 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China.)

出处: Journal of molecular cell biology 2023

关键词: HMGA2;METTL3;N6-methyladenosine;epithelial–mesenchymal transition;subretinal fibrosis.

摘要: Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration (nAMD). Myofibroblast ...

作者: Changjiang Gu #  1, Fanqi Kong #  1, Junkai Zeng #  1, Xiangwu Geng  1, Yanqing Sun  2, Xiongsheng Chen  3   4 (Affiliations 1 Spine Center, Department of Orthopaedics, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200003, People's Republic of China. 2 Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, 200080, Shanghai, PR China. syq04281226@126.com. 3 Spine Center, Department of Orthopaedics, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200003, People's Republic of China. chenxiongsheng@vip.sohu.com. 4 Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, 200080, Shanghai, PR China. chenxiongsheng@vip.sohu.com.)

出处: Cell & bioscience 2023

关键词: Ischemia reperfusion injury;Oxidative stress;RIPC;SIRT3.

摘要: Background: To study the protective effects of delayed remote ischemic preconditioning (RIPC) against spinal cord ischemia-reperfusion injury (SCIRI) ...

作者: J G Hong (Affiliation 1 Department of Pediatrics, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.)

出处: Zhonghua er ke za zhi = Chinese journal of pediatrics 2023

摘要: 喘息是6岁以下儿童常见的呼吸道症状,导致儿童喘息原因多样,年龄越小喘息的病因越复杂,要重视儿童喘息的病因分析,以免延误诊断。早期采用抗炎为主的干预措施有益于气道炎症相关性喘息症状的改善,但需及时评估干预效应,避免过度用药。.

作者: Di Cui;Jianneng Li;Ziqi Zhu;Michael Berk;Aimalie Hardaway;Jeffrey McManus;Yoon-Mi Chung;Mohammad Alyamani;Shelley Valle;Ritika Tiwari;Bangmin Han;Maryam Goudarzi;Belinda Willard;Nima Sharifi (Affiliations 1 Genitourinary Malignancies Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA. 2 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Metabolomics Shared Laboratory Resource, Lerner Research Institute. 4 Department of Urology, Glickman Urological and Kidney Institute, and. 5 Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.)

出处: The Journal of clinical investigation 2023

关键词: Oncology;Prostate cancer;Sex hormones.

摘要: After androgen deprivation, prostate cancer frequently becomes castration resistant (CRPC), with intratumoral androgen production from extragonadal pr ...

作者: Zhenyang Shen;Weiming Dai;Yuecheng Guo;Junjun Wang;Bo Shen;Binghang Li;Lungen Lu;Xiaobo Cai (Affiliations 1 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023

关键词: Yes-associated protein;ductular reaction;liver fibrosis;liver progenitor cells;transplantation.

摘要: Liver fibrosis is closely related to the proliferation and differentiation of liver progenitor cells (LPCs). Yes-associated protein (YAP) is a key eff ...

作者: Jifu Ge;Weikang Pan;Noel J Feeney;Leah Ott;Emily Anderson;Alessandro Alessandrini;Ivan Zanoni;James F Markmann;Alex G Cuenca (Affiliations 1 Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China. 2 Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA. 3 Massachusetts General Hospital, Division of Transplant Surgery, Department of Medicine, Boston, MA 02114, USA. 4 Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, MA 02114, USA; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. USA. 5 Department of Medicine, Division of Gastroenterology/Immunology, Boston Children's Hospital, Boston, MA 02115, USA. 6 Massachusetts General Hospital, Division of Transplant Surgery, Department of Medicine, Boston, MA 02114, USA; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, MA 02114, USA. 7 Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, MA 02114, USA. Electronic address: alex.cuenca@childrens.harvard.edu.)

出处: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023

摘要: Advances in immunosuppression have been relatively stagnant over the last 2 decades and transplant recipients continue to experience long term morbidi ...

作者: Y X Qian;S Y Liu;X J Wang;S J Xia (Affiliation 1 Department of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Institute of Urology, Shanghai Jiao Tong University, Shanghai 200080, China.)

出处: Zhonghua yi xue za zhi 2023

摘要: Benign prostatic hyperplasia (BPH) is one of the most common diseases in elderly men. Transurethral resection of prostate (TURP), as an important BPH ...

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