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作者: Limin Liao  1   2   3, Qinggang Liu  1   2   3, Huiling Cong  1   2, Zhihui Xu  4, Enhui Li  4, Zhiliang Weng  5, Haihong Jiang  5, Ben Liu  6, Xiao Huang  6, Shujie Xia  7, Wei Wen  7, Juan Wu  1   2, Guowei Shi  8, Yang Wang  8, Peijun Li  9, Yang Yu  9, Zujun Fang  10, Jie Zheng  10, Ye Tian  11, Donghao Shang  11, Hanzhong Li  12, Zhongming Huang  12, Liqun Zhou  13, Yunxiang Xiao  13, Yaoguang Zhang  14, Jianlong Wang  14, Xiaodong Zhang  15, Peng Zhang  15, Dongwen Wang  16, Xuhui Zhang  16, Keji Xie  17, Bin Wang  17, Lulin Ma  18, Xiaojun Tian  18, Lijun Chen  19, Jinkai Dong  19 (Affiliations 1 Department of Urology, China Rehabilitation Research Center, School of Rehabilitation Medicine, Capital Medical University, Beijing, China. 2 Cheeloo College of Medicine, Shandong University, Jinan, China. 3 University of Health and Rehabilitation Sciences, Qingdao, China. 4 Department of Urology, Zhejiang Provincial People\'s Hospital, Hangzhou, China. 5 Department of Urology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 6 Department of Urology, First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. 7 Department of Urology, Shanghai First People\'s Hospital, Shanghai, China. 8 Department of Urology, Shanghai Fifth People\'s Hospital, Shanghai, China. 9 Department of Urology, Ningxia Medical University General Hospital, Xining, China. 10 Department of Urology, Huashan Hospital, Fudan University, Shanghai, China. 11 Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. 12 Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. 13 Department of Urology, Peking University First Hospital, Beijing, China. 14 Department of Urology, Beijing Hospital, Beijing, China. 15 Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. 16 Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, China. 17 Department of Urology, Guangzhou First People\'s Hospital, Guangzhou, China. 18 Department of Urology, Peking University Third Hospital, Beijing, China. 19 Department of Urology, Fifth Medical Center of PLA General Hospital, Beijing, China.)

出处: Frontiers in pharmacology 2022 Vol.13 P840695

关键词: China;Hengli®;botulinum toxin type A;overactive bladder;randomized controlled trial.

摘要: Objective: To evaluate the efficacy and safety of Hengli ® Chinese botulinum toxin type A (BTX-A; 100 U) in Chinese patients with overactive bladder. ...

作者: YaQing Zhan  1, YiHong Ling  2   3, Qiwen Deng  1, YuXin Qiu  1, JianTong Shen  1, HanJin Lai  1, ZhaoRong Chen  1, ChanYan Huang  1, LiQun Liang  4, Xiang Li  5, JianFeng Wu  4, WenQi Huang  6, ShiHong Wen  6 (Affiliations 1 Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 2 State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. 3 Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China. 4 Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; and. 5 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; huangwenqi86@aliyun.com wshih@mail.sysu.edu.cn.)

出处: Journal of immunology (Baltimore, Md. : 1950) 2022 Vol.208 No.4 P968-978

摘要: Influx of activated neutrophils into the lungs is the histopathologic hallmark of acute lung injury (ALI) after intestinal ischemia/reperfusion (I/R). ...

[外文期刊] Highly-metastatic colorectal cancer cell released miR-181a-5p-rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment
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作者: Senlin Zhao  1   2, Yushuai Mi  3, Binbin Zheng  4, Ping Wei  2   5   6, Yanzi Gu  7, Zhengxiang Zhang  8, Ye Xu  1   2, Sanjun Cai  1   2, Xinxiang Li  1   2, Dawei Li  1   2 (Affiliations 1 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 3 Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. 4 Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. 5 Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. 6 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China. 7 Department of Biobank, Fudan University Shanghai Cancer Center, Shanghai, China. 8 Department of Oncology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.)

出处: Journal of extracellular vesicles 2022 Vol.11 No.1 Pe12186

关键词: CCL20/CCR6/ERK1/2/Elk-1/miR-181a-5p feedback loop;colorectal liver metastasis;extracellular vesicle;hepatic stellate cell;miR-181a-5p;tumour microenvironment.

摘要: Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC-related mortality, and is typically caused by interactions between CRC ce ...

作者: Chenglei Su  1   2, Yan Xiao  2   3   4, Guozhen Zhang  2, Lian Liang  2, Hui Li  2, Cheng Cheng  2, Tao Jin  2, Jennifer Bradley  2, Mary A Peberdy  2   5, Joseph P Ornato  2   6, Martin J Mangino  2   7, Wanchun Tang  2   6 (Affiliations 1 Department of Emergency Medicine Center, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. 2 Weil Institute of Emergency and Critical Care Research, Virginia Commonwealth University, Richmond, VA. 3 Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Emergency Medicine, The Second Affiliated Hospital of Soochow University, Soochow, China. 5 Departments of Internal Medicine and Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA. 6 Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA. 7 Department of Surgery, Virginia Commonwealth University Health System, Richmond, VA.)

出处: Critical care medicine 2022 Vol.50 No.2 Pe189-e198

摘要: Objectives: To investigate the therapeutic potential and underlying mechanisms of exogenous nicotinamide adenine dinucleotide+ on postresuscitation my ...

作者: Rui Zhang  1   2   3, Xiaotong Sun  4, Ya Li  5, Wenzheng He  6, Hongguang Zhu  7, Baoshan Liu  1   2   3, Aiyuan Zhang  1   2   3 (Affiliations 1 Department of Cardiology, 117907Weifang People\'s Hospital, the First Affiliated Hospital of Weifang Medical University, Weifang, China. 2 Cardiac Care Unit, 117907Weifang People\'s Hospital, the First Affiliated Hospital of Weifang Medical University, Weifang, China. 3 Cardiac Rehabilitation Centre, 117907Weifang People\'s Hospital, the First Affiliated Hospital of Weifang Medical University, Weifang, China. 4 Shandong Provincial Medicine and Health Key Laboratory of Clinical Anesthesia, Department of Anesthesiology, Weifang Medical University, Weifang, China. 5 Department of Cardiology, Shanghai General Hospital, School of Medicine, 12474Shanghai Jiaotong University, Hongkou District, Shanghai, China. 6 Intensive Care Unit, 117907Weifang People\'s Hospital, the First Affiliated Hospital of Weifang Medical University, Weifang, China. 7 Dental Department, 117907Weifang People\'s Hospital, the First Affiliated Hospital of Weifang Medical University, Weifang, China.)

出处: Journal of cardiovascular pharmacology and therapeutics 2022 Vol.27

关键词: angiotensin receptor-neprilysin inhibitor;efficacy;heart failure;sacubitril/valsartan;safety.

摘要: Heart failure (HF) is one of the leading causes of morbidity and mortality worldwide. Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibit ...

作者: Xiaoming Li #  1, Fang Li #  2   3, Xixi Zhang  1, Haiwei Zhang  1, Qun Zhao  1, Ming Li  1, Xiaoxia Wu  1, Lingxia Wang  1, Jianling Liu  1, Xuanhui Wu  1, Yangjing Ou  1, Mingyan Xing  1, Yue Zhang  4, Jiangshan Deng  5, Xiuzhe Wang  5, Yan Luo  4, Jinbao Li  2, Yuwu Zhao  5, Haibing Zhang  6 (Affiliations 1 CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. 2 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, China. 3 The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China. 4 Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People\'s Hospital, Shanghai, China. 6 CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. hbzhang@sibs.ac.cn.)

出处: Cell death and differentiation 2022

摘要: Caspase-8 is an initiator of death receptor-induced apoptosis and an inhibitor of RIPK3-MLKL-dependent necroptosis. In addition, caspase-8 has been im ...

作者: Zuyin Li  1   2   3, Guohe Song  3, Dezhen Guo  3, Zhijie Zhou  4, Chen Qiu  5, Chao Xiao  6, Xiaoliang Wang  7, Yupeng Wang  3 (Affiliations 1 Department of Hepatobiliary Surgery, Peking University Organ Transplantation Institute, Peking University People\'s Hospital, Beijing, 100034, China. 2 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. 3 Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. 4 Department of General Surgery, Huashan Hospital North, Fudan University, Shanghai 201907, China. 5 Institute of Gallstone Disease, Center of Gallbladder Disease, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. 6 Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 20040, China. 7 Department of General Surgery, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, 201700, China.)

出处: Journal of Cancer 2022 Vol.13 No.2 P610-622

关键词: DNA replication;GINS2;cell cycle;immune cell infiltration..

摘要: Background: GINS2 has been reported to have prognostic value in several solid tumors other than hepatocellular carcinoma (HCC), and its influence on t ...

作者: Yi Zhang  1   2   3, Min Ji  4, Jin-Yan Zhao  5, Hua-Feng Wang  1   2   3   6, Chong-Wu Wang  7, Wei Li  4, Jing-Jing Ye  4, Fei Lu  4, Li-Hui Lin  5, Yan-Ting Gao  5, Jie Jin  1   2   3   6, Li Li  5, Chun-Yan Ji  4, Joan Ballesteros  8, Hong-Hu Zhu  1   2   3   6 (Affiliations 1 Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. 2 Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, China. 3 Zhejiang University Cancer Center, Hangzhou, China. 4 Department of Hematology, Qilu Hospital, Shandong University, Jinan, China. 5 Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, China. 7 R & D Department, Hosea Medical Technology (Beijing) Co., Ltd., Beijing, China. 8 R & D Department, Vivia Biotech, Madrid, Spain.)

出处: Frontiers in oncology 2022 Vol.11 P793773

关键词: acute myeloid leukemia;chemosensitivity;complete remission;ex vivo drug sensitivity test;precision medicine.

摘要: We evaluated the predictive value of the ex-vivo PharmaFlow PM platform in measuring the pharmacological activity of drug combinations consisting of 2 ...

[外文期刊] Downregulation of the LncRNA MEG3 Promotes Osteogenic Differentiation of BMSCs and Bone Repairing by Activating Wnt/β-Catenin Signaling Pathway
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作者: Juan Liu  1, Xin Qi  2, Xiao-Hong Wang  3, Hong-Sheng Miao  1, Zi-Chao Xue  4, Le-Le Zhang  5, San-Hu Zhao  1, Liang-Hao Wu  2, Guo-Yi Gao  1, Mei-Qing Lou  1, Cheng-Qing Yi  2 (Affiliations 1 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. 2 Department of Orthopaedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No. 2800 Gongwei Road, Huinan Town, Pudong, Shanghai 201399, China. 3 Department of Operating Room, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No. 2800 Gongwei Road, Huinan Town, Pudong, Shanghai 201399, China. 4 Department of Orthopaedics, Qingdao Municipal Hospital, Qingdao 266001, China. 5 Department of Nursing, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No. 2800 Gongwei Road, Huinan Town, Pudong, Shanghai 201399, China.)

出处: Journal of clinical medicine 2022 Vol.11 No.2 P395

关键词: BMSCs;MEG3;bone regeneration;long non-coding RNA;skull defect.

摘要: Background: Previous studies have demonstrated that long non-coding RNA maternally expressed gene 3 (MEG3) emerged as a key regulator in development a ...

[外文期刊] c-Myc participates in high glucose-mediated endothelial inflammation via upregulation of IRAK1 expression in diabetic nephropathy
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作者: Wenting Hou  1, Lihong Lu  1, Xue Li  1, Minli Sun  2, Minmin Zhu  3, Changhong Miao  4 (Affiliations 1 Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. 2 Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: sunminli@sina.com. 3 Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. Electronic address: zhu_mm@126.com. 4 Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: miao_chh@126.com.)

出处: Cellular signalling 2022 Vol.92 P110263

关键词: Diabetic nephropathy;Endothelial adhesive molecules;IRAK1;KMT5A;c-Myc.

摘要: Diabetic nephropathy (DN) is a common vascular complication of diabetes. Endothelial adhesion molecules are involved in physiopathology of DN. Interle ...

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