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作者: Gaozhen Jia  1, Xingjie Wang  1, Wenbo Wu  1, Yu Zhang  1, Shaoan Chen  1, Jing Zhao  1, Wei Zhao  1, Weiguo Li  1, Xiaowen Sun  2, Bangmin Han  3 (Affiliations 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Wujin Road 85, Shanghai, 200080, China; Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. 2 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Wujin Road 85, Shanghai, 200080, China; Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. Electronic address: sunxiaow1973@163.com. 3 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Wujin Road 85, Shanghai, 200080, China; Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. Electronic address: hanbm@163.com.)

出处: International immunopharmacology 2022 Vol.107 P108586

关键词: LXA4;METTL3;Macrophages;Prostate cancer;STAT6.

摘要: Tumor-associated macrophages (TAMs) are major innate immune cells that play crucial roles in prostate cancer onset and progression. Recently, increasi ...

作者: Min Chen #  1, Chencheng Yao #  2, Yingying Qin #  3, Xiuhong Cui  4, Peng Li  2, Zhiyong Ji  2, Limei Lin  4   5   6, Haowei Wu  4   5   6, Zhi Zhou  7, Yaoting Gui  8, Zheng Li  9, Fei Gao  10   11   12 (Affiliations 1 Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, P. R. China. 2 Department of Andrology, the Center for Men\'s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China. 3 Center for Reproductive Medicine of Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, P. R. China. 4 State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China. 5 University of Chinese Academy of Sciences, Beijing, P. R. China. 6 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. 7 School of Life Science and Technology, ShanghaiTech University, Shanghai, P. R. China. 8 Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, P. R. China. guiyaoting2007@aliyun.com. 9 Department of Andrology, the Center for Men\'s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China. lizhengboshi@163.com. 10 State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China. gaof@ioz.ac.cn. 11 University of Chinese Academy of Sciences, Beijing, P. R. China. gaof@ioz.ac.cn. 12 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. gaof@ioz.ac.cn.)

出处: Signal transduction and targeted therapy 2022 Vol.7 No.1 P1

作者: Chen Feng  1   2   3, Yan Yang  2   3, Lixiao Chen  1, Ruixiang Guo  2   3, Huayang Liu  2   3, Chaojie Li  2   3, Yan Wang  2   3, Pin Dong  1, Yanzhong Li  2   3 (Affiliations 1 Department of Otolaryngology Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 2 Department of Otorhinolaryngology, Qilu Hospital, Shandong University Cheeloo College of Medicine, Jinan, China. 3 NHC Key Laboratory of Otorhinolaryngology (Shandong University), Jinan, China.)

出处: Frontiers in endocrinology 2022 Vol.13 P812974

关键词: IIEF-5 questionnaire;erectile dysfunction;obstructive sleep apnea;polysomnography;sex hormones.

摘要: Background: Obstructive sleep apnea (OSA) is a common and severe social problem. Erectile dysfunction (ED) is an important health concern. The prevale ...

作者: Rong Wang  1, Lingbin Che  2, Qian Feng  1, Kaiyong Cai  1 (Affiliations 1 Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. 2 Department of Orthopedics Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.)

出处: ACS applied materials & interfaces 2022

关键词: alendronate;amphoteric copolymer;bone regeneration;hydrogel;mesenchymal stem cells.

摘要: Bone tissue scaffolds with good bulk or surface osteoconductivity are always pursued by biomaterial scientists. In this paper, we design a tough and f ...

作者: Zhixian Yao #  1   2, Zhong Zheng #  2, Xinyi Zheng #  3, Hantao Wu  1, Weiguang Zhao  1, Xingyu Mu  1, Feng Sun  1, Ke Wu  2, Junhua Zheng  1   2 (Affiliations 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. 2 Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, China.)

出处: Oxidative medicine and cellular longevity 2022 Vol.2022 P9039732

摘要: Renal cell carcinoma (RCC) is a disease characterized by excessive administration complexity because it exhibits extraordinary nonuniformity among dis ...

作者: Xiao Zhou  1   2, Yu Cai  1   2, Jun Yang  1   2, Yin Tong  1   2, Huiying Qiu  1   2, Chongmei Huang  1   2, Kun Zhou  1   2, Xiaowei Xu  1   2, Jiahua Niu  1   2, Xinxin Xia  1   2, Ying Zhang  1   2, Chang Shen  1   2, Yu Wei  1   2, Xianmin Song  1   2, Liping Wan  1   2 (Affiliations 1 Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Engineering Technology Research Center of Cell Therapy and Clinical Translation, Shanghai Science and Technology Committee (STCSM), Shanghai, China.)

出处: Cell transplantation 2022 Vol.31

关键词: absolute lymphocyte count;anti-thymocyte globulin;haploidentical;peripheral blood stem cell transplantation;relapse;survival.

摘要: Standard anti-thymocyte globulin (ATG) weight-based dosing often resulted in highly variable ATG exposure, which had profound effects on relapse and s ...

作者: Shasha Song  1, Yuanyuan Guo  2, Yuehua Yang  3, Dehao Fu  4 (Affiliations 1 College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, PR China. 2 Department of Pharmacy, Liyuan Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei 430077, PR China. 3 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. 4 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. Electronic address: fudehao@sjtu.edu.cn.)

出处: Pharmacology & therapeutics 2022 P108168

关键词: Alpha-ketoglutarate;Autophagy;Cellular senescence;Gut microbiome;Hydrogen sulfide;Iron balance;Osteoporosis;Probiotics;Senolytics.

摘要: Osteoporosis, is the most common bone disorder worldwide characterized by low bone mineral density, leaving affected bones vulnerable to fracture. Bon ...

作者: Jing Ke  1, Kun Li  1, Tingyu Ke  2, Xu Zhong  3   4, Qidong Zheng  5, Yufan Wang  6, Li Li  7, Yuancheng Dai  8, Qijuan Dong  9, Bangqun Ji  10, Fengmei Xu  11, Juan Shi  3   4, Ying Peng  3   4, Yifei Zhang  3   4, Dong Zhao  1, Weiqing Wang  3   4 (Affiliations 1 Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China. 2 Department of Endocrinology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China. 3 Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the P. R. China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Internal Medicine, The Second People\'s Hospital of Yuhuan, Yuhuan, China. 6 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 7 Department of Endocrinology, Ningbo First Hospital, Ningbo, China. 8 Department of Internal Medicine of Traditional Chinese Medicine, Sheyang Diabetes Hospital, Yancheng, China. 9 Department of Endocrinology and Metabolism, People\'s Hospital of Zhengzhou Affiliated Henan University of Chinese Medicine, Zhengzhou, China. 10 Department of Endocrinology, Xingyi People\'s Hospital, Xinyi, China. 11 Department of Endocrinology and Metabolism, Hebi Coal (group). LTD. General Hospital, Hebi, China.)

出处: Journal of diabetes 2022 Vol.14 No.1 P64-72

关键词: 2型糖尿病;carotid plaque;sedentary;type 2 diabetes mellitus;久坐;颈动脉斑块.

摘要: Background: Atherosclerosis is a common complication in patients with type 2 diabetes (T2DM). Multiple factors are involved in the development and pro ...

作者: Chun Yang  1, Lijian Lang  2, Zhenghui He  3, Jiyuan Hui  4, Jiyao Jiang  5   6, Guo-Yi Gao  7, Jun-Feng Feng  8 (Affiliations 1 Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People\'s Republic of China., Department of Neurosurgery, 160 Pujian Road, Shanghai, Shanghai, China, 200127; yc_life@163.com. 2 Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, 71140, Neurosurgery, Shanghai, Shanghai, China; lang_lijian@163.com. 3 Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, 71140, Neurosurgery, Shanghai, Shanghai, China; hezhenghui8@hotmail.com. 4 Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, 71140, Neurosurgery, Shanghai, Shanghai, China; weilaiyisheng@126.com. 5 Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, 71140, Department of Neurosurgery, Shanghai, China. 6 Shanghai Institute of Head Trauma, Shanghai, China; jiyaojiang@126.com. 7 Shanghai General Hospital, 12482, Department of Neurosurgery, Shanghai, China; gao3@sina.com. 8 Renji hospital, Shanghai Jiaotong University, Neurosurgery Department, No.1630, Dongfang Road, Shanghai, China, 200127; fengjfmail@163.com.)

出处: Journal of neurotrauma 2022

关键词: CLINICAL TRIAL;GERIATRIC BRAIN INJURY;TRAUMATIC BRAIN INJURY.

摘要: Increasing traumatic brain injury (TBI) among older adults constitutes a substantial socioeconomic burden, in step with the growing aging global popul ...

作者: Zhiying Yue1,2;Xin Niu1;Zengjin Yuan1;Qin Qin1;Wenhao Jiang3;Liang He3;Jingduo Gao1;Yi Ding1;Yanxi Liu1;Ziwei Xu1;Zhenxi Li4;Zhengfeng Yang1,2;Rong Li1;Xiwen Xue1;Yankun Gao5;Fei Yue6;Zhang, Xiang H.-F6;Guohong Hu7;Yi Wang5;Yi Li6 (1 Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China 2 Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 3 Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, China 4 Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China 5 State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China 6 Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA 7 CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China)

出处: Journal of Clinical Investigation 2022 Vol.132 No.2 P1-19

关键词: Bone Biology;Bone disease;Breast cancer;Cell Biology;Signal transduction

摘要: Therapeutics targeting osteoclasts are commonly used treatments for bone metastasis; however, whether and how osteoclasts regulate premetastatic niche ...

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