作者： Bingbing Feng^1,2;Yuxin Chen^3,2;Haizhou Fu^4,2;Yufei Li⁵;Jingjing Guo⁵;Xixi Hou^6,7CA1;Huibin Xu^8,9CA2;Shuxiang Xu^10,11CA3 （¹School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210046, China;²These authors contributed equally to this work.;³Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China;⁴School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, 310053, China;⁵Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao Special Administrative Region of China;⁶School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, China;⁷The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471003, China;⁸Precision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China;⁹State Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China;¹⁰Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China;¹¹College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, China）

出处： European Journal of Medicinal Chemistry 2026

关键词： Ferroptosis;GPX4;Melanoma;Triazole-benzoxazine.

摘要： Melanoma, a highly metastatic cancer with rising incidence, faces therapeutic challenges due to drug resistance and recurrence. In this study, we desi ...

作者： Jiachang Hong¹, Penghao Ji¹, Jinxi An¹, Junchao Huang¹, Ziheng Bu¹, Xudong Zhang¹, Wei Liu¹, Tingyu Wu¹, Sen Wang¹, Wei Zhu¹, Yuhui Li¹, Jixian Wan¹, Sudan Xu², Minfeng Huo¹, Peng Wu¹ （Affiliations ¹ Department of Orthopedics, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, P. R. China. ² Department of Geriatric, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026

关键词： anti‐inflammatory;macrophage reprogramming;myricetin‐arginine conjugate nanozymes;osteoclastogenesis;rheumatoid arthritis.

摘要： Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and progressive joint destruction driven by macropha ...

作者： Junzhe Xie¹;Fangjing Ni¹;Jialiang Shao¹;Dongliang Zhang¹;Tuanjie Guo¹CA1;Xiang Wang¹CA2 （¹Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Cancer Letters 2026

摘要： Kidney cancer is a major global health burden, with clear cell renal cell carcinoma (ccRCC) as the most common and aggressive subtype. Beyond the typi ...

作者： Penglin Zou ¹, Tingting Lei ², Yan Cui ³, Zheng Li ⁴, Qiusheng Shi ¹, Rong Wu ¹, Jianlin Hu ⁵, Xin Li ⁶ （Affiliations ¹ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China (P.Z., Q.S., R.W., X.L.). ² Department of Ultrasound, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao 266000, Shandong Province, China (T.L.). ³ Department of Biomedical Engineering, University of Oklahoma, Oklahoma, Norman, 73071 (Y.C.). ⁴ Department of Andrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China (Z.L.). ⁵ Department of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China (J.H.). ⁶ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China (P.Z., Q.S., R.W., X.L.). Electronic address: lixin198404@163.com.）

出处： Academic radiology 2026

关键词： Contrast-enhanced ultrasound;Hemodynamics;Male infertility;Varicocele.

摘要： Rationale and objectives: Contrast-enhanced ultrasound (CEUS) is an effective method for assessing varicocele (VC) hemodynamics; however, its value in ...

作者： Tao Zhang^1,2;Heng Du^3,2;Yifu Wang^3,2;Yue Gu^4,2;Xiaoyan Song³;Yijue Shen³;Haiyan Lu³;Kan Fang³;Qimin Hu³;Qiaoshu Wang³CA1;Guodong Wang³CA2 （¹Department of Laboratory Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China;²Contributed equally.;³Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong Special Administrative Region）

出处： Journal of the Neurological Sciences 2026

摘要： Background Bell's palsy has been suggested as a possible adverse event of the inactivated SARS-CoV-2 vaccine. The aim of this study is to examine the ...

作者： Mingwei Xu^1,2;Qiong Wu^3,2;Tianyu Gong^1,2;Yuan Yao³;Qin Zhang³;Qianqian Zhang⁴;Ting Han^5,6CA1;Yong Gu⁷CA2;Qing Zhang¹CA3 （¹Department of Otolaryngology, Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;²These authors contributed equally to this work and share first authorship.;³Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China;⁴Department of Otolaryngology Head and Neck Surgery, Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China;⁵School of Design, Shanghai Jiao Tong University, Shanghai 200240, China;⁶Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China;⁷Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China）

出处： Hearing Research 2026

摘要： Accurate quantification of behavioral deficits is critical for investigating vestibular disorders, yet current assessment methods often fail to captur ...

作者： Kexing Zhuo^1,2,3;Man Mou^1,2,3;Jianlun Li^1,2,4,3;Sijian Huang^1,2,5,3;Zihang Zeng^1,2;Xu Li^1,2;Lijuan Wang^1,2;Yingjie Wei²;Shijia Qiu^1,2;Xianghong Wei^1,2;Lei Li¹CA1;Yuan Cao^1,6CA2;Maohua Zhong^1,2,7CA3 （¹Wuhan Asia General Hospital, College of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei 430056, China;²Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China;³These authors contributed equally to this work.;⁴Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei Province, 443002, China;⁵Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;⁶Analytical & Testing Center, Wuhan University of Science and Technology, Wuhan, Hubei 430065, China;⁷Lead contact.）

出处： International Immunopharmacology 2026

摘要： The development of effective cancer vaccines remains challenged by tumor heterogeneity and insufficient T-cell activation. Whole-cell vaccines, which ...

作者： Yayue Song ¹, Lucia Luengo-Gutierrez ¹, Virag Sagi-Kiss ², Guiping Kong ³, Helen Huang ², Moritz Steinruecke ¹, Luming Zhou ³, Zhulin Yuan ¹, Francesco De Virgiliis ⁴, Istvan Pap ⁵, Charlotte Decourt ¹, Yuyang Yan ¹, Hee Hwan Park ¹, Hanqi Zhang ⁶, Jiahui Wei ³, Elizabeth Want ², Xuemei Tong ⁶, Zoltan Takats ², Simone Di Giovanni ⁷ （Affiliations ¹ Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK. ² Division of System Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK. ³ Precision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China; State Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China. ⁴ Department of Pathology and Immunology, University of Geneva, Geneva 1211, Switzerland. ⁵ Department of Immunomedicine, University of Regensburg, Regensburg, Germany. ⁶ Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, State Key Laboratory of Eye Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK. Electronic address: s.di-giovanni@imperial.ac.uk.）

出处： Cell 2026

关键词： TKT;axon regeneration;homeostasis;mechanical sensation;nerve injury;neuronal metabolism;pentose phosphate pathway;ribose;spinal cord injury;transcription.

摘要： Homeostasis and repair in the nervous system are thought to rely on distinct molecular programs. Here, we uncover an unexpected role for the pentose p ...

作者： Dan Zou^1,21;Jike Hu^1,22;Yunpeng Wang^1,23;Puyi He^1,24;Lei Gao¹5;Huanhuan Ma¹6;Ying Yan¹7;Yifan Li¹8;Kai Wang¹9;Weiyi Chen¹10;Bofang Wang¹11;Xiaotong Wang¹12;Hao Chen^1,3,4,5,6CA13 （¹The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China;²These authors contributed equally to this work.;³Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai, 201620, China;⁴Gansu Provincial Key Laboratory of Environmental Oncology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China;⁵Department of Surgical Oncology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China;⁶The Key Laboratory of Humanized Animal Models, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China）

出处： Critical Reviews in Oncology/Hematology 2026

关键词： Cancer;Drug delivery system;LRP1;Therapeutic resistance;Tumor microenvironment.

摘要： Low-density lipoprotein receptor-related protein 1 (LRP1), a key member of the Low-density lipoprotein receptor (LDLR) family, is a transmembrane rece ...

作者： Andrew Chang  ¹, Xiaodong Sun  ², Tomohiro Iida  ³, Timothy Y Y Lai  ⁴, Tien Y Wong  ⁵, Chui Ming Gemmy Cheung  ⁶, Won Ki Lee  ⁷, Xin Zhang  ⁸, Andrea Schulze  ⁹, Ursula Maria Schmidt-Ott  ⁹, Min Zhao  ¹⁰, Zoran Hasanbasic  ¹¹, Sergio Leal  ¹¹, Shih-Jen Chen  ¹²; PULSAR study investigators （Affiliations ¹ Sydney Retina Clinic, Sydney, NSW, Australia. Electronic address: achang@sydneyretina.com.au. ² Shanghai General Hospital, Shanghai, China. ³ Department of Ophthalmology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan. ⁴ Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. ⁵ Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. ⁶ Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore. ⁷ Nune Eye Hospital, Gangnam District, Seoul, Republic of Korea. ⁸ Bayer Consumer Care AG, Basel, Switzerland. ⁹ Bayer AG, Berlin, Germany. ¹⁰ Bayer Healthcare Co. Ltd., Beijing, China. ¹¹ Bayer Australia Ltd., Pymble, NSW, Australia. ¹² Department of Ophthalmology, Taipei Veterans General Hospital, Taipei City, Taiwan; National Yang Ming Chiao Tung University, Taipei City, Taiwan.）

出处： Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2026

关键词： Asian population;PULSAR;aflibercept 8mg;intraocular pressure;neovascular age-related macular degeneration.

摘要： Purpose: To evaluate 1-year efficacy and safety of aflibercept 8mg in Asian patients with neovascular age-related macular degeneration (nAMD) in the P ...