作者： Wenzhe Yi  ^{1   2}, Xindi Qian  ¹, Dan Yan  ¹, Wenlu Yan  ^{1   2}, Shuangshuang Hu  ^{1   3}, Yaping Li  ^{1   2   4}, Dangge Wang  ⁵ （Affiliations ¹ State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. ² University of Chinese Academy of Sciences, Beijing, 100049, China. ³ School of Life Sciences, Jilin University, Changchun, 130012, China. ⁴ Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, 264000, China. ⁵ Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.）

出处： Advanced materials (Deerfield Beach, Fla.) 2025

关键词： anti‐PD‐L1 antibody;dendritic cells;immunotherapy;tumor‐derived lymph nodes.

摘要： Targeted blockade of immune checkpoints within tumor-draining lymph nodes (TDLNs) represents a promising strategy to potentiate immune checkpoint bloc ...

作者： Yangguang Huang  ^{1   2}, Ting Chen  ³, Chunling Ren  ³, Bingkun Bao  ³, Rongkun Huang  ^{1   2}, Yingxiao Sun  ², Changlong Yu  ⁴, Yunlong Yang  ¹, Wing Tak Wong  ⁵, Qingmei Zeng  ³, Li Jiang  ³, Tuan Liu  ³, Qiuning Lin  ³, Linyong Zhu  ³, Yun Liao  ¹ （Affiliations ¹ Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. ³ School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. ⁴ Burn Plastic Wound Repair Surgery of Ganzhou Hospital of Guangdong Provincial People's Hospital, GanZhou, 341000, China. ⁵ School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, 999077, China.）

出处： Advanced materials (Deerfield Beach, Fla.) 2025

关键词： 3D printing;bone repair;gelatin hydrogels;high strength;osteoporosis;remodel microenvironment.

摘要： Osteoporosis is a widespread condition that induces an inflammatory microenvironment, limiting the effectiveness of conventional therapies and present ...

作者： Zhi Yuan Ning  ¹, Jing Lan Zhang  ², Bing Bing Fan  ³, Yan Lin Qu  ⁴, Chang Su  ⁵, Tao Zhang  ⁶ （Affiliations ¹ Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China. ² Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;School of Life Science, Shandong University, Qingdao 266237, Shandong, China. ³ Food is Medicine Institute, Friedman School of Nutrition Science & Policy, Tufts University, Boston, MA 02148, USA. ⁴ Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁵ National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China. ⁶ Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China;Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin 300070, China.）

出处： Biomedical and environmental sciences : BES 2025

关键词： Body mass index;Diabetes Mellitus;Homeostasis model assessment of insulin resistance;Longitudinal studies.

摘要： Objective: This study aimed to explore the interplay between the life-course body mass index (BMI) trajectories and insulin resistance (IR) on inciden ...

作者： Hanlai Li  ¹, Tingting Gu  ¹, Jingjing Xu  ¹, Lin Gan  ¹, Chang Liu  ², Jixian Wan  ³, Zhihao Mu  ⁴, Haiyan Lyu  ⁵, Zhibin Wang  ⁶, Qianqian Liu  ⁷, Jie Chen  ⁸, Yaohui Tang  ¹ （Affiliations ¹ School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. ² Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ³ Department of Rehabilitation Medicine, Ruijin Hospital, School of Medicine, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. ⁴ Department of Pathology and Pathophysiology, Faculty of Basic Medical Sciences, Kunming Medical University, Kunming, Yunan Province, China. ⁵ Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Lingyi iTECH Manufacturing Co., Ltd., Suzhou, Jiangsu Province, China. ⁷ Ankerui (Shanxi) Biological Cell Co., Ltd., Taiyuan, Shanxi Province, China. ⁸ Jiangsu Charity Biotech Co., Ltd., Shanghai, China.）

出处： Biomaterials translational 2025

关键词： Biomaterials;Clinical translation;Hydrogel;Stroke.

摘要： Due to the limited effects of current treatments on brain repair and regeneration, stroke continues to be the predominant cause of death and long-term ...

作者： Yifan Hu ^{#  1}, Longzhe Gao ^{#  2}, Qiangrong Wang  ¹, Jin Chen  ¹, Shanshan Jiang  ³, Genqing Zhou  ², Jiayin Zhang  ⁴ （Affiliations ¹ Dongtai People's Hospital, Yancheng, Jiangsu, China. ² Cardiology, Shanghai General Hospital, Shanghai, China. ³ Bayer HealthCare Co Ltd, Beijing, China. ⁴ Radiology, Shanghai General Hospital, Shanghai, China andrewssmu@msn.com.）

出处： Open heart 2025

关键词： Atrial Fibrillation;Biomarkers;Computed Tomography Angiography.

摘要： Objectives: This study aimed to establish a prediction model that incorporates the radiomic features of epicardial adipose tissue (EAT) to predict atr ...

作者： Jinliang Wang  ^{1   2}, Zhiping Zhang  ², Qiuli Wang  ², Li Wen  ³, Jiaqi Liu  ², Changzhan Gu  ³, Peiyao Xiao  ¹, Ziyang Fang  ¹, Yikai Li  ¹, Xianfeng Yao  ⁴, Zhi Zhang  ² （Affiliations ¹ School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China. ² Department of Cardiology, Shanghai General Hospital (originally named Shanghai First People's Hospital), Shanghai Jiaotong University School of Medicine, Shanghai, China. ³ MoE Key Lab of Artificial Intelligence and State Key Laboratory of Radio Frequency Heterogeneous Integration, Shanghai Jiao Tong University, Shanghai, China. ⁴ Department of Nursing, Shanghai General Hospital (originally named Shanghai First People's Hospital), Shanghai Jiaotong University School of Medicine, Shanghai, China.）

出处： Medical science monitor : international medical journal of experimental and clinical research 2025

摘要： BACKGROUND Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a common and serious sleep disorder characterized by recurrent episodes of partial or ...

作者： Hui Li  ^{1   2}, Qinghua Niu  ², Chao Jia  ², Gaoxiang Fan  ², Long Liu  ², Gang Li  ², Penglin Zou  ², Rong Wu  ², Lianfang Du  ², Jing Wang  ³, Qiusheng Shi  ² （Affiliations ¹ Department of Ultrasound, Huashan Hospital, Fudan University, Shanghai, China. ² Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： The breast journal 2025

关键词： breast;contrast-enhanced ultrasound;conventional ultrasound;pseudoangiomatous stromal hyperplasia.

摘要： Purpose: To investigate the conventional ultrasound and contrast-enhanced ultrasound (CEUS) imaging features of pseudoangiomatous stromal hyperplasia ...

作者： Lili Hou¹;Lili Hou²;Yonglu Guo²;Yurong Zhang²;Zhenghua Zhu³;Ningfang Lian⁴;Ying Gong⁵;Bairong Du²;Yuanyuan Liu⁶;Jichen Qu²;Xian Zhu²;Lei Zhu⁷ （¹Department of Respiratory and Critical Care Medicine, Jiuquan Branch of Shanghai General Hospital, Gansu, China;²Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;³Department of Otolaryngology, Jiuquan Branch of Shanghai General Hospital, Gansu, China;⁴Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Institute of Respiratory Disease, Fujian Medical University, Fujian, China;⁵Department of Respiratory and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China;⁶Department of Respiratory and Critical Care Medicine, Dunhuang General Hospital, Dunhuang, China;⁷Department of Critical and Pulmonary Medicine, Huadong Hospital, Fudan University, Shanghai, China）

出处： Frontiers in Allergy 2025

关键词： aging;small airway;small airway dysfunction;spirometry;the area under receiver operating characteristic curves

摘要： BackgroundSmall airway function naturally declines with aging. However, the precise age this decline begins in healthy Chinese individuals remains unc ...

作者： Song Guo  ¹, Rui-Ning Hang  ², Kai Zhu  ³, Chen-Qiong Wu  ⁴, Mei-Jun Yan  ⁵, Xin-Hua Li  ⁵, Yan-Bin Liu  ⁴, Qiang Fu  ⁶ （Affiliations ¹ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ² Department of Public Health Studies, Johns Hopkins University, Baltimore, MD 21218, United States. ³ Department of Spine Surgery, Qingdao No. 8 People's Hospital, Qingdao 266121, Shandong Province, China. ⁴ Department of Spine Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. ⁵ Department of Orthopedics Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. ⁶ Department of Spine Surgery, Shanghai General Hospital, Shanghai 200080, China. 2293259778@qq.com.）

出处： World journal of orthopedics 2025

关键词： Bilateral symptoms;Biportal full-endoscopy technique;Clinical outcomes;Lumbar spinal stenosis;Uniportal full-endoscopy technique.

摘要： Background: Uniportal full-endoscopy (UFE) technique has been continuously developed and applied for treating lumbar spinal stenosis. However, achievi ...

作者： Yan Shen  ¹, Xingmei Zhou  ¹, Jiaqi Yu  ¹, Jian Chang  ², Xin Li  ³, Xianrui Li  ³, Huiyan Zhang  ³ （Affiliations ¹ Department of Nursing, Shanghai General Hospital, Shanghai, China. ² Department of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University School of Nursing, Shanghai, China. ³ Department of Vascular Access Outpatient, Shanghai General Hospital, Shanghai, China.）

出处： The journal of vascular access 2025

关键词： PICC-port;Ultrasound-based;educational program;placement;specialized nurse;tip location.

摘要： Objectives: To create an educational program and provide a valid, evidence-based course for ultrasound-based tip location during placement of PICC-por ...