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作者: Wan Sun  1, Juan Wang  2, Caiying Liu  1, Furong Gao  1, Qingjian Ou  3, Haibin Tian  1, Jingying Xu  1, Jieping Zhang  3, Jiao Li  4, Jie Xu  4, Song Jia  4, Jingfa Zhang  5, GuoTong Xu  6, Jian Huang  7, Caixia Jin  8, Lixia Lu  9 (Affiliations 1 Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai 200065, China. 2 Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Medical Genetics, School of Medicine, Tongji University, Shanghai 200065, China. 3 Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Pharmacology, School of Medicine, Tongji University, Shanghai 200065, China. 4 Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai 200065, China. 5 Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200025, China. 6 Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Pharmacology, School of Medicine, Tongji University, Shanghai 200065, China. Electronic address: gtxu@tongji.edu.cn. 7 Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: jyhuanj@shsmu.edu.cn. 8 Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai 200065, China. Electronic address: 12060@tongji.edu.cn. 9 Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai 200065, China. Electronic address: lulixia@tongji.edu.cn.)

出处: International journal of biological macromolecules 2024

关键词: Glia maturation factor-β (GMFB);Hyperglycemia;Protein stability;Retinal pigment epithelial cells;SUMOylation.

摘要: Background: Glia maturation factor beta (GMFB) is a growth and differentiation factor that acts as an intracellular regulator of signal transduction p ...

作者: Shuchang Zhang  1, Shimei Chen  1, Dandan Sun  1, Shenping Li  1, Jun Sun  1, Qing Gu  1, Peiyu Liu  1, Xiaoqian Wang  1, Hong Zhu  1, Xun Xu  1, Huiming Li  2, Fang Wei  3 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 2 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: li_huiming73@163.com. 3 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: weifang73@hotmail.com.)

出处: Cellular signalling 2024

关键词: Diabetic retinopathy;Mitophagy;Senescence;TIN2;mTOR.

摘要: The telomere-associated protein TIN2 localizes to both telomeres and mitochondria. Nevertheless, the impact of TIN2 on retinal pigment epithelial (RPE ...

作者: Lingxuan Zhu MD1,2;Weiming Mou MD3,2;Peng Luo MD1CA11Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China;2Lingxuan Zhu and Weiming Mou have contributed equally to this work and share first authorship.;3Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Clinical Gastroenterology and Hepatology 2024

作者: Youwei Lu  1, Yu Sun  1, Jie Zhang  1, Miao Kong  1, Zhiming Zhao  1, Boshu Sun  1, Yuan Wang  1, Ying Jiang  2, Shaomu Chen  3, Chao Wang  4, Yin Tong  5, Liangzhu Wen  6, Moli Huang  7, Fengying Wu  8, Liang Zhang  9 (Affiliations 1 College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China. 2 Department of Hematology, Shanghai Zhaxin Traditional Chinese and Western Medicine Hospital, Shanghai, China. 3 Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. 4 Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu, China. 5 Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 He Cheng Biotechnology Suzhou Co.Ltd, Suzhou, Jiangsu, China. 7 Department of Bioinformatics, School of Biology & Basic Medical Sciences, Soochow University, Suzhou, China. 8 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: 1701823@tongji.edu.cn. 9 College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China. Electronic address: zliang@suda.edu.cn.)

出处: Cancer letters 2024

关键词: B7–H4;Deubiquitination;EGFR MT;Tumor immunosuppression;USP2a.

摘要: B7-H4 is an immune checkpoint crucial for inhibiting CD8+ T-cell activity. A clinical trial is underway to investigate B7-H4 as a potential ...

作者: Jingwen Chen  1, Rui Yang  2, Hongwei Yu  1, Hao Wu  3, Nan Wu  3, Suhe Wang  4, Xiaorui Yin  1, Xiangyang Shi  2, Han Wang  1   5   6   7 (Affiliations 1 Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Haining Rd.100, Shanghai 200080, China. han.wang@shsmu.edu.cn. 2 Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China. 3 School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China. 4 Department of Internal Medicine, Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA. 5 R & D Center of Medical Artificial Intelligence and Medical Engineering, Haining Rd.100, Shanghai General Hospital, Shanghai 200080, China. 6 National Center for Translational Medicine (Shanghai), New Songjiang Rd.650, Shanghai 201620, China. 7 Jiading Branch of Shanghai General Hospital, Huangjia Garden Rd. 800, Shanghai 201803, China.)

出处: Journal of materials chemistry. B 2024

摘要: Ultrasmall iron oxide nanoparticles (USIO NPs) are expected to become the next generation T1 contrast agents; however, their diagnostic and ...

作者: Rui Kong  1, Nan Wang  2, Chun Li Zhou  1, Jie Lu  3   2 (Affiliations 1 Department of Gastroenterology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, P.R. China. 2 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China. 3 Department of Gastroenterology, Pu Dong Area Gongli Hospital, School of Medicine, Shanghai University, Shanghai 200135, P.R. China.)

出处: Journal of microbiology and biotechnology 2024

关键词: Long non-coding RNA;hepatocellular carcinoma;immune prognostic signature;overall survival.

摘要: In recent years, there has been a growing recognition of the important role that long non-coding RNAs (lncRNAs) play in the immunological process of h ...

作者: Cai Zhang  1, Xuejiao Song  1, Chuan Ma  2, Minjia Wang  1, Hui Deng  3, Miaomiao Yuan  4, Wuyou Zhu  5, Lingyue Shen  6, Yuzhen Li  7, Leilei Shi  8 (Affiliations 1 The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. 2 Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, China. 3 Department of Dermatology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: hdeng@sjtu.edu.cn. 4 Shanghai Key Laboratory of Pancreatic Diseases, Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Shanghai Foreign Language School Affiliated to Shanghai International Studies University, Shanghai, China. 6 Department of Oral & Maxillofacial-Head & Neck Oncology, Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: sharyshen@hotmail.com. 7 The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. Electronic address: liyzh56@mail.sysu.edu.cn. 8 Shanghai Key Laboratory of Pancreatic Diseases, Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: leilei.shi@shgh.cn.)

出处: International journal of biological macromolecules 2024

关键词: Dissolving microneedle;Hyaluronic acid;Melanin;Melasma;Tranexamic acid.

摘要: Melasma is an acquired hypermelanotic condition characterized by the presence of irregular light-to-dark brown macules that primarily manifest on the ...

作者: Jun Hou  1   2   3, Hui Du  1   2   3, Chun Wang  1   2   3, Fangbin Song  4, Xinfeng Qu  5, Ruifang Wu  1   2   3 (Affiliations 1 Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, China. 2 Institute of Obstetrics and Gynecology, Shenzhen Peking University-Hongkong University of Science and Technology (PKU-HKUST) Medical Center, Shenzhen, China. 3 Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecologic Diseases, Peking University Shenzhen Hospital, Shenzhen, China. 4 Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. 5 Department of Obstetrics and Gynecology, Sanming Project of Medicine in Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.)

出处: Frontiers in oncology 2024

关键词: P16 immunocytochemical stain;atrophy;cytology;high-grade squamous intraepithelial lesion (HSIL);menopause.

摘要: Background: Few articles have focused on the cytological misinterpretation of high-grade squamous intraepithelial lesion (HSIL). Due to estrogen defic ...

作者: Bin Zhang  1   2, Rui Yang  2   3, Hongwei Yu  4, Yamin Peng  2, Haoyu Huang  2, Meera Moydeen Abdul Hameed  5, Han Wang  4, Guixiang Zhang  1, Mohamed El-Newehy  5, Mingwu Shen  2, Xiangyang Shi  2   6, Shaojun Peng  7 (Affiliations 1 Department of Radiology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China. Guixiangzhang@sina.com. 2 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China. xshi@dhu.edu.cn. 3 Medical School, Kunming University of Science and Technology, Kunming 650500, China. 4 Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 5 Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia. 6 CQM-Centro de Quimica da Madeira, Universidade da Madeira, Funchal 9020-105, Portugal. 7 Center for Biological Science and Technology & College of Arts and Sciences, Beijing Normal University, Zhuhai 519087, China. 91122024006@bnu.edu.cn.)

出处: Biomaterials science 2024

摘要: Developing effective nanomedicines to cross the blood-brain barrier (BBB) for efficient glioma theranostics is still considered to be a challenging ta ...

作者: Kangkang Ou  1, Yang Liu  2, Lili Deng  3, Shiyan Chen  4, Song Gu  5, Baoxiu Wang  6 (Affiliations 1 School of Textiles and Fashion, Shanghai University of Engineering Science, Shanghai 201620, PR China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China. 2 School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, PR China. 3 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China. 4 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China. Electronic address: chensy@dhu.edu.cn. 5 Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, PR China. Electronic address: song.gu@shgh.cn. 6 School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, PR China. Electronic address: baoxiu.wang@mail.dhu.edu.cn.)

出处: International journal of biological macromolecules 2024

关键词: Anti-cell adhesion;Antibacterial activity;Bacterial cellulose;Wound dressing.

摘要: Hydrogel-based wound dressings are becoming increasingly important for wound healing. Bacterial cellulose (BC) has been commonly used as wound dressin ...

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