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[外文期刊] Factors Associated with Progression of Different Prediabetic Status to Diabetes: A Community-based Cohort Study
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作者: Na Li  1, Chunhua Lu  2, Yuhang Ma  1, Xuejiao Wang  1, Yunxia Ling  1, Yanhua Yin  1, Shumei Li  3, Jiao Huang  1, Lihua Yu  2, Weiping Dong  1, Huichen He  4, Mei Kang  4, Lei Ma  4, Mingyu Gu  1, Li Zhao  1, Yunhong Huang  1, Fang Liu  1, Yufan Wang  1, Xianying Gai  5, Junyi Jiang  6, Yongde Peng  7, Xiaoying Ding  8 (Affiliations 1 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 2 Community Health Service Center of Sijing, Songjiang District, Shanghai 201601, China. 3 Department of Endocrinology and Metabolism, Shanghai Fourth People\'s Hospital, School of Medicine, Tongji University, Shanghai 200434, China. 4 Clinical Research Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 5 Department of Endocrinology, Sijing Hospital, Songjiang District, Shanghai 201601, China. 6 Department of Clinical Pharmacology, Xiangya Hospital, Central South University and Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410008, PR China. Electronic address: jiangjy@live.cn. 7 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Electronic address: pengyongde0908@126.com. 8 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Electronic address: xiaoyingding@126.com.)

出处: Diabetes research and clinical practice 2022 P109193

关键词: combined glucose intolerance (CGI);insulin resistance;insulin secretion;prediabetes;progress.

摘要: Aims: To examine the predictive factors associated with the progression of different prediabetic status to diabetes. Methods: A two-year retrospective ...

作者: Tao Wang  1   2, Jing Lu  1, Rangrang Wang  1, Wanyue Cao  1, Junming Xu  1 (Affiliations 1 Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China. 2 Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.)

出处: Journal of Cancer 2022 Vol.13 No.2 P589-601

关键词: EMT;Hepatocellular carcinoma;TOP2A;cell cycle;miR-144-3p.

摘要: Topoisomerase II alpha (TOP2A) is an important nuclear protein which is found in various types of cancers. Whether TOP2A plays an important role in he ...

[外文期刊] Predicting Clear Cell Renal Cell Carcinoma Survival Using Kurtosis of Cytoplasm in the Hematoxylin Channel from Histology Slides
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作者: Jun Wang  1, Jianhui Chen  2, Liren Jiang  3, Qi Wu  1   4, Dawei Wang  5 (Affiliations 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 2 Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China. 3 Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 4 Department of Urology, The Sixth Affiliated Hospital of Wenzhou Medical University (The People\'s Hospital of Lishui), Wenzhou, Zhejiang 323000, China. 5 Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.)

出处: Journal of oncology 2022 Vol.2022 P7693993

摘要: Purpose: Grade-dependent decrease of lipid storage in clear cell renal cell carcinoma (ccRCC) leads to morphology changes in HE sections. This study i ...

[外文期刊] Leukemia inhibitory factor receptor homodimerization mediated by acetylation of extracellular lysine promotes prostate cancer progression through the PDPK1/AKT/GCN5 axis
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作者: Yufeng Ding  1, Jialiang Shao  2, Tiezhu Shi  2, Hua Yu  1, Xiang Wang  2, Honggang Chi  3, Xiongjun Wang  1 (Affiliations 1 School of Life Sciences, Guangzhou University, Guangzhou, China. 2 Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. 3 Department of Traditional Chinese Medicine, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, China.)

出处: Clinical and translational medicine 2022 Vol.12 No.2 Pe676

摘要: Background: Prostate cancer (PCa), an inert tumour, has a long progression period, but valid biomarkers and methods for effectively and sensitively mo ...

[外文期刊] Cerebrospinal Fluid Extracellular Vesicles with Distinct Properties in Autoimmune Encephalitis and Herpes Simplex Encephalitis
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作者: Yongang Li  1, Jiachen Gu  2, Youbing Mao  3, Xijia Wang  1, Zongshan Li  4, Xiaomin Xu  4, Huimin Chen  4, Yaxing Gui  5 (Affiliations 1 Department of Neurology, The First People\'s Hospital of Wenling, Wenling, China. 2 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.86 Wujin Road, Shanghai, 200080, China. 3 Department of Neuroelectrophysiology, The First People\'s Hospital of Wenling, Wenling, China. 4 Department of Neurology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China. 5 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.86 Wujin Road, Shanghai, 200080, China. YaxingGui@shsmu.edu.cn.)

出处: Molecular neurobiology 2022

关键词: Autoimmune encephalitis (AE);Exosomes;Herpes simplex encephalitis (HSE);microRNAs.

摘要: Encephalitis mediated by autoantibodies against neuronal antigens and herpes simplex encephalitis (HSE) are seemingly separate causes of encephalopath ...

作者: Shanshan Hu  1, Shuowen Wang  1, Chendong Qi  1, Shengying Gu  1, Chenyang Shi  1, Lin Mao  1, Guorong Fan  1 (Affiliation 1 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Frontiers in pharmacology 2022 Vol.13 P831364

关键词: UKPDS OM;cost-utility analysis;dulaglutide;extended-release exenatide;once-weekly GLP-1 receptor agonist;subcutaneous semaglutide;type 2 diabetes.

摘要: Introduction: The substantial financial burden associated with type 2 diabetes (T2D) over a lifetime cannot be neglected. Therefore, the objective of ...

[外文期刊] Targeting Protein Kinase C for Cancer Therapy
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作者: Sijia He  1, Qi Li  1, Qian Huang  1, Jin Cheng  1 (Affiliation 1 Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.)

出处: Cancers 2022 Vol.14 No.5 P1104

关键词: cancer;cell death;protein kinase C;targeted therapy.

摘要: Protein kinase C (PKC) isoforms, a group of serine-threonine kinases, are important regulators in carcinogenesis. Numerous studies have demonstrated t ...

[外文期刊] Schisandrol A, the main active ingredient of Schisandrae Chinensis Fructus, inhibits pulmonary fibrosis through suppression of the TGF-β signaling pathway as revealed by UPLC-Q-TOF/MS, network pharmacology and experimental verification
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作者: Zhenghua Wu  1, Mengqi Jia  2, Wenjuan Zhao  3, Xucong Huang  4, Xinyi Yang  5, Dongxin Chen  6, Xijier Qiaolongbatu  7, Xiaojing Li  8, Jiaqi Wu  9, Feng Qian  10, Yuefen Lou  11, Guorong Fan  12 (Affiliations 1 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: wuzhenghua526@163.com. 2 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: 346852884@qq.com. 3 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: zhaowj@sjtu.edu.cn. 4 School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China. Electronic address: 1109060643@qq.com. 5 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: Xinyi2017@sjtu.edu.cn. 6 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: 770512829doudou@sjtu.edu.cn. 7 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: 962689538@qq.com. 8 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: l_xiaojing@yeah.net. 9 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: wjq731030@126.com. 10 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: fengqian@sjtu.edu.cn. 11 Department of Pharmacy, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200434, PR China. Electronic address: louyuefen@sina.cn. 12 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: fanguorong@sjtu.edu.cn.)

出处: Journal of ethnopharmacology 2022 Vol.289 P115031

关键词: Idiopathic pulmonary fibrosis;Network pharmacology;Schisandra chinensis;Schisandrol A;TGF-β signaling pathway;UPLC-Q-TOF/MS.

摘要: Ethnopharmacological relevance: Schisandra chinensis decoction derived from the book of Waitai Miyao (Tao Wang, Tang dynasty) is often used in the tre ...

[外文期刊] Telescreening satisfaction: disparities between individuals with diabetic retinopathy and community health center staff
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作者: Xiaofeng Zhu #  1   2   3   4   5, Yi Xu #  1   2, Lina Lu  6   7, Haidong Zou  8   9   10   11   12 (Affiliations 1 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 4 National Clinical Research Center for Eye Diseases, Shanghai, China. 5 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. 6 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. lulina781019@qq.com. 7 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lulina781019@qq.com. 8 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. zouhaidong@sjtu.edu.cn. 9 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zouhaidong@sjtu.edu.cn. 10 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 11 National Clinical Research Center for Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 12 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn.)

出处: BMC health services research 2022 Vol.22 No.1 P160

关键词: Community health centers;Satisfaction;Telescreening;Vision-threatening diabetic retinopathy.

摘要: Background: The success of telescreening and the management of diabetic retinopathy (DR) in communities depends on stakeholder satisfaction, including ...

[外文期刊] Novel bi-allelic MSH4 variants causes meiotic arrest and non-obstructive azoospermia
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作者: Peng Li #  1, Zhiyong Ji #  1   2, Erlei Zhi  1, Yuxiang Zhang  1, Sha Han  1, Liangyu Zhao  1, Ruhui Tian  1, Huixing Chen  1, Yuhua Huang  1, Jing Zhang  3, Huirong Chen  1, Fujun Zhao  1, Zhi Zhou  4, Zheng Li  5, Chencheng Yao  6   7 (Affiliations 1 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 2 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211116, China. 3 The Reproductive Medicine Research Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510620, China. 4 School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. zhouzhi@shanghaitech.edu.cn. 5 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. lizhengboshi@sjtu.edu.cn. 6 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. yaochencheng@126.com. 7 School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. yaochencheng@126.com.)

出处: Reproductive biology and endocrinology : RB&E 2022 Vol.20 No.1 P21

关键词: MSH4;Male infertility;Meiosis;Non-obstructive azoospermia.

摘要: Background: Non-obstructive azoospermia (NOA) is one of the most severe type in male infertility, and the genetic causes of NOA with meiotic arrest re ...

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