作者： Tao Wang  ^{1   2}, Jing Lu  ¹, Rangrang Wang  ¹, Wanyue Cao  ¹, Junming Xu  ¹ （Affiliations 1 Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China. 2 Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.）

出处： Journal of Cancer 2022 Vol.13 No.2 P589-601

关键词： EMT;Hepatocellular carcinoma;TOP2A;cell cycle;miR-144-3p.

摘要： Topoisomerase II alpha (TOP2A) is an important nuclear protein which is found in various types of cancers. Whether TOP2A plays an important role in he ...

作者： Jun Wang  ¹, Jianhui Chen  ², Liren Jiang  ³, Qi Wu  ^{1   4}, Dawei Wang  ⁵ （Affiliations 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 2 Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China. 3 Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 4 Department of Urology, The Sixth Affiliated Hospital of Wenzhou Medical University (The People\'s Hospital of Lishui), Wenzhou, Zhejiang 323000, China. 5 Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.）

出处： Journal of oncology 2022 Vol.2022 P7693993

摘要： Purpose: Grade-dependent decrease of lipid storage in clear cell renal cell carcinoma (ccRCC) leads to morphology changes in HE sections. This study i ...

作者： Yufeng Ding  ¹, Jialiang Shao  ², Tiezhu Shi  ², Hua Yu  ¹, Xiang Wang  ², Honggang Chi  ³, Xiongjun Wang  ¹ （Affiliations 1 School of Life Sciences, Guangzhou University, Guangzhou, China. 2 Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. 3 Department of Traditional Chinese Medicine, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, China.）

出处： Clinical and translational medicine 2022 Vol.12 No.2 Pe676

摘要： Background: Prostate cancer (PCa), an inert tumour, has a long progression period, but valid biomarkers and methods for effectively and sensitively mo ...

作者： Yongang Li  ¹, Jiachen Gu  ², Youbing Mao  ³, Xijia Wang  ¹, Zongshan Li  ⁴, Xiaomin Xu  ⁴, Huimin Chen  ⁴, Yaxing Gui  ⁵ （Affiliations 1 Department of Neurology, The First People\'s Hospital of Wenling, Wenling, China. 2 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.86 Wujin Road, Shanghai, 200080, China. 3 Department of Neuroelectrophysiology, The First People\'s Hospital of Wenling, Wenling, China. 4 Department of Neurology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China. 5 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.86 Wujin Road, Shanghai, 200080, China. YaxingGui@shsmu.edu.cn.）

出处： Molecular neurobiology 2022

关键词： Autoimmune encephalitis (AE);Exosomes;Herpes simplex encephalitis (HSE);microRNAs.

摘要： Encephalitis mediated by autoantibodies against neuronal antigens and herpes simplex encephalitis (HSE) are seemingly separate causes of encephalopath ...

作者： Shanshan Hu  ¹, Shuowen Wang  ¹, Chendong Qi  ¹, Shengying Gu  ¹, Chenyang Shi  ¹, Lin Mao  ¹, Guorong Fan  ¹ （Affiliation 1 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Frontiers in pharmacology 2022 Vol.13 P831364

关键词： UKPDS OM;cost-utility analysis;dulaglutide;extended-release exenatide;once-weekly GLP-1 receptor agonist;subcutaneous semaglutide;type 2 diabetes.

摘要： Introduction: The substantial financial burden associated with type 2 diabetes (T2D) over a lifetime cannot be neglected. Therefore, the objective of ...

作者： Sijia He  ¹, Qi Li  ¹, Qian Huang  ¹, Jin Cheng  ¹ （Affiliation 1 Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.）

出处： Cancers 2022 Vol.14 No.5 P1104

关键词： cancer;cell death;protein kinase C;targeted therapy.

摘要： Protein kinase C (PKC) isoforms, a group of serine-threonine kinases, are important regulators in carcinogenesis. Numerous studies have demonstrated t ...

作者： Zhenghua Wu  ¹, Mengqi Jia  ², Wenjuan Zhao  ³, Xucong Huang  ⁴, Xinyi Yang  ⁵, Dongxin Chen  ⁶, Xijier Qiaolongbatu  ⁷, Xiaojing Li  ⁸, Jiaqi Wu  ⁹, Feng Qian  ¹⁰, Yuefen Lou  ¹¹, Guorong Fan  ¹² （Affiliations 1 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: wuzhenghua526@163.com. 2 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: 346852884@qq.com. 3 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: zhaowj@sjtu.edu.cn. 4 School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China. Electronic address: 1109060643@qq.com. 5 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: Xinyi2017@sjtu.edu.cn. 6 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: 770512829doudou@sjtu.edu.cn. 7 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: 962689538@qq.com. 8 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: l_xiaojing@yeah.net. 9 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: wjq731030@126.com. 10 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: fengqian@sjtu.edu.cn. 11 Department of Pharmacy, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200434, PR China. Electronic address: louyuefen@sina.cn. 12 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: fanguorong@sjtu.edu.cn.）

出处： Journal of ethnopharmacology 2022 Vol.289 P115031

关键词： Idiopathic pulmonary fibrosis;Network pharmacology;Schisandra chinensis;Schisandrol A;TGF-β signaling pathway;UPLC-Q-TOF/MS.

摘要： Ethnopharmacological relevance: Schisandra chinensis decoction derived from the book of Waitai Miyao (Tao Wang, Tang dynasty) is often used in the tre ...

作者： Xiaofeng Zhu ^{#  1   2   3   4   5}, Yi Xu ^{#  1   2}, Lina Lu  ^{6   7}, Haidong Zou  ^{8   9   10   11   12} （Affiliations 1 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 4 National Clinical Research Center for Eye Diseases, Shanghai, China. 5 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. 6 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. lulina781019@qq.com. 7 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lulina781019@qq.com. 8 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. zouhaidong@sjtu.edu.cn. 9 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zouhaidong@sjtu.edu.cn. 10 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 11 National Clinical Research Center for Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 12 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn.）

出处： BMC health services research 2022 Vol.22 No.1 P160

关键词： Community health centers;Satisfaction;Telescreening;Vision-threatening diabetic retinopathy.

摘要： Background: The success of telescreening and the management of diabetic retinopathy (DR) in communities depends on stakeholder satisfaction, including ...

作者： Peng Li ^{#  1}, Zhiyong Ji ^{#  1   2}, Erlei Zhi  ¹, Yuxiang Zhang  ¹, Sha Han  ¹, Liangyu Zhao  ¹, Ruhui Tian  ¹, Huixing Chen  ¹, Yuhua Huang  ¹, Jing Zhang  ³, Huirong Chen  ¹, Fujun Zhao  ¹, Zhi Zhou  ⁴, Zheng Li  ⁵, Chencheng Yao  ^{6   7} （Affiliations 1 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 2 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211116, China. 3 The Reproductive Medicine Research Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510620, China. 4 School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. zhouzhi@shanghaitech.edu.cn. 5 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. lizhengboshi@sjtu.edu.cn. 6 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. yaochencheng@126.com. 7 School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. yaochencheng@126.com.）

出处： Reproductive biology and endocrinology : RB&E 2022 Vol.20 No.1 P21

关键词： MSH4;Male infertility;Meiosis;Non-obstructive azoospermia.

摘要： Background: Non-obstructive azoospermia (NOA) is one of the most severe type in male infertility, and the genetic causes of NOA with meiotic arrest re ...

作者： Xinran Qin  ¹, Haidong Zou  ^{2   3   4   5   6} （Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zouhaidong@sjtu.edu.cn. 3 Shanghai Eye Diseases Prevention & Treatment Center, Shanghai Eye Hospital, Shanghai, China. zouhaidong@sjtu.edu.cn. 4 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 5 National Clinical Research Center for Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 6 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn.）

出处： BMC ophthalmology 2022 Vol.22 No.1 P86

关键词： Blood-retina barrier;Diabetic retinopathy;Dysbiosis;Gut leakage;Inflammation;Lipopolysaccharides;Retinal glia.

摘要： Diabetes mellitus (DM) is a complex metabolic syndrome characterized by hyperglycemia. Diabetic retinopathy (DR) is the most common complication of DM ...