作者： Liwen Zhong  ¹, Danjun Xu  ², Jingyi He  ², Lianhui Sun  ³, Guangjian Fan  ³, Ting Zhu  ³, Yufeng Yao  ⁴, Tingting Feng  ⁵, Zelin Cui  ⁶ （Affiliations ¹ Laboratory of Bacterial Pathogenesis, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Laboratory of Bacterial Pathogenesis, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yfyao@sjtu.edu.cn. ⁵ Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: ycttfeng@163.com. ⁶ Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: czl@sjtu.edu.cn.）

出处： International journal of medical microbiology : IJMM 2025

关键词： Antibodies;Dermal abscess;Exposure;Phage JD007;S. aureus;Therapeutic efficacies.

摘要： Objectives: phage therapy is a promising approach for infections caused by drug-resistant bacteria; this study evaluated the impact of pre-exposure to ...

作者： Chaoliang Xu ^{#  1}, Jingpiao Bao ^{#  2   3}, Deshen Pan  ¹, Kehong Wei  ¹, Qing Gao  ¹, Weihong Lin  ⁴, Yujie Ma  ⁴, Meiqing Lou  ⁵, Cheng Chang  ⁶, Deshui Jia  ¹ （Affiliations ¹ Department of Thoracic Surgery, Institute of Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China. ⁵ Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.）

出处： Translational lung cancer research 2025

关键词： ATF3;Lung adenocarcinoma (LUAD);brain metastasis (BrM);single-cell RNA sequencing (scRNA-seq);spatial transcriptomics (ST).

摘要： Background: Brain metastasis (BrM) has been a challenge for lung cancer treatment, but the mechanisms underlying lung cancer BrM remain elusive. This ...

作者： Yichao Ma  ^{1   2}, Jiangpeng Wu  ², Yanlong Dong  ³, Hongmei Tang  ¹, Xiaojun Ma  ² （Affiliations ¹ Shanghai University of Traditional Chinese Medicine, Shanghai, China. ² Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Linyan Medical Technology Company Limited, Shanghai, China.）

出处： Orthopaedic surgery 2025

关键词： accuracy;augmented reality;navigation;pedicle screw;thoracolumbar spine.

摘要： Objective: The pedicle screw insertion technique has evolved significantly, and despite the challenges of precise placement, advancements like AR-base ...

作者： Chunling Ren  ¹, Wanqi Chen  ¹, Yun Liao  ², Yangguang Huang  ³, Changlong Yu  ⁴, Ting Chen  ¹, Qingmei Zeng  ¹, Yunlong Yang  ², Rongkun Huang  ³, Tuan Liu  ¹, Li Jiang  ¹, Bingkun Bao  ¹, Linyong Zhu  ¹, Qiuning Lin  ¹ （Affiliations ¹ School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. ² Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. ⁴ Burn Plastic Wound Repair Surgery of Ganzhou Hospital of Guangdong Provincial People's Hospital, GanZhou, 341000, China.）

出处： Advanced materials (Deerfield Beach, Fla.) 2025

关键词： 3D printing;biomaterials;gelatin hydrogels;mechanical performance;tissue engineering.

摘要： Gelatin hydrogels (e.g., methacrylated gelatin gel, abbreviated GelMA gel) have garnered significant attention in tissue engineering and therapeutic d ...

作者： Zheng Zhang  ^{1   2}, Jiaxing Wang  ¹, Xiaofang Li  ¹, Lingzhou Zhao  ³, Junwei Zhao  ⁴, Mengjiao Su  ¹, Xiangxiang Wu  ¹, Huahui Zeng  ¹ （Affiliations ¹ Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, China. ² Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou, China. ³ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Clinical Laboratory, Core Unit of National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.）

出处： Drug delivery 2025

关键词： Ginsenoside Rg3;celastrol;nanoparticles;pancreatic cancer;prodrug.

摘要： Celastrol (Cel) is a potential anticancer therapeutic candidate, but its limited practical applicability is due to its low solubility, poor tumor sele ...

作者： Yilu Zheng  ¹, Gareth R Williams  ², Ran Hu  ¹, Sen Tong  ³, Jianxiang Xu  ¹, Tong Wang  ¹, Yanyan Zhang  ¹, Junzi Wu  ³, Fan Li  ⁴, Yingyu Cai  ⁴, Li-Min Zhu  ¹ （Affiliations ¹ College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People's Republic of China. ² UCL School of Pharmacy, University College London, London, WC1N 1AX, UK. ³ The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People's Republic of China. ⁴ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People's Republic of China.）

出处： International journal of nanomedicine 2025

关键词： Calcium ion load;anti-cancer;controlled-release nanomaterials;pH responsive drug release;reactive oxygen species;two-layer protective shell.

摘要： Background: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great p ...

作者： Ziwei Luo ^{#  1   2}, Chencen Lin ^{#  2   3}, Chuwei Yu  ⁴, Changxian Yuan  ³, Wenyong Wu  ⁴, Xiaowei Xu  ⁵, Renhong Sun  ⁶, Yan Jia  ⁴, Yafang Wang  ², Jie Shen  ⁷, Dingyan Wang  ⁴, Sinan Wang  ⁸, Hualiang Jiang  ^{1   2   9}, Biao Jiang  ^{1   2}, Xiaobao Yang  ⁶, Chengying Xie  ^{1   2   4} （Affiliations ¹ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. ² Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China. ³ School of Physical Science and Technology, ShanghaiTech University, Shanghai, China. ⁴ Lingang Laboratory, Shanghai, China. ⁵ Department of Hematology, Shanghai Jiao Tong University School of Medicine Affiliated Shanghai General Hospital, Shanghai, China. ⁶ Gluetacs Therapeutics (Shanghai) Co., Ltd., Shanghai, China. ⁷ Department of Pharmacy, The SATCM Third Grade Laboratory of Traditional Chinese Medicine Preparations, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. ⁸ School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China. ⁹ Drug Discovery and Development Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.）

出处： Cancer research 2025

摘要： Son of sevenless homolog 1 (SOS1) is an essential guanine nucleotide exchange factor for RAS that also plays a critical role in the activation of the ...

作者： Danling Cheng  ¹, Libai Luo  ², Qin Zhang  ³, Zheming Song  ⁴, Yiduo Zhan  ⁴, Wenzhi Tu  ⁵, Jingchao Li  ⁴, Qiming Ma  ⁶, Xianchang Zeng  ¹ （Affiliations ¹ Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310009, China. ² Oncology Chemotherapy Department, Affiliated Hospital of Youjiang Medical University for Nationalities and Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Baise, 533000, China. ³ Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China. ⁴ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China. ⁵ Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ⁶ Department of General Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： calcium overload;immunotherapy;radiodynamic therapy;second messengers;smart nanotherapeutic.

摘要： Various second messengers exert some vital actions in biological systems, including cancer therapy, but the therapeutic efficacy is often need to be i ...

作者： Yazhou Wu  ^{1   2   3   4   5}, Hanhua Li  ^{1   3   4   5}, Yin Long  ^{5   6}, Zhenzhen Zhang  ⁵, Fanping Zhang  ⁵, Runyu Pan  ^{1   3   4}, Leijun Meng  ^{1   3   4}, Zhan Ma  ^{1   3   4}, Kaijing Wang  ⁷, Bing Zheng  ², Zhonghong Qie  ⁸, Wei Gao  ⁹ （Affiliations ¹ Department of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ² Department of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Clinical Laboratory, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China. ⁶ Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Department of Hepatobiliary Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. ⁸ Department of Clinical Laboratory, Shanghai health and medical center, Wuxi, China. ⁹ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Molecular carcinogenesis 2025

关键词： RNF4;Wnt signaling pathway;colorectal cancer;epigenetic silencing;miR‐137.

摘要： Colorectal cancer (CRC) is a significant health issue worldwide. Recent studies highlight the critical role of miRNAs in CRC development, particularly ...

作者： Yufang Sun  ^{1   2}, Yu Tao  ², Junping Cao  ³, Yaqun Zhang  ², Zitong Huang  ², Shoupeng Wang  ², Weiwei Lu  ², Qi Zhu  ², Lidong Shan  ², Dongsheng Jiang  ^{4   5}, Yuan Zhang  ^{6   7   8}, Jin Tao  ^{9   7   8} （Affiliations ¹ Department of Geriatrics, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China. ² Department of Physiology and Neurobiology, Centre for Ion Channelopathy, Suzhou Medical College of Soochow University, Suzhou 215123, China. ³ Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, China. ⁴ Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ⁵ Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich 81377, Germany. ⁶ Department of Geriatrics, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China taoj@suda.edu.cn yuanzhang@suda.edu.cn. ⁷ Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou 215123, China. ⁸ MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China. ⁹ Department of Physiology and Neurobiology, Centre for Ion Channelopathy, Suzhou Medical College of Soochow University, Suzhou 215123, China taoj@suda.edu.cn yuanzhang@suda.edu.cn.）

出处： The Journal of neuroscience : the official journal of the Society for Neuroscience 2025

关键词： histone methylation;miR-216a-3p;neuropathic pain;stromal interaction molecule 1;trigeminal ganglion neurons.

摘要： Although the therapeutic potential of microRNA-mediated gene regulation has been investigated, its precise functional regulatory mechanism in neuropat ...