作者： Yilu Zheng  ¹, Gareth R Williams  ², Ran Hu  ¹, Sen Tong  ³, Jianxiang Xu  ¹, Tong Wang  ¹, Yanyan Zhang  ¹, Junzi Wu  ³, Fan Li  ⁴, Yingyu Cai  ⁴, Li-Min Zhu  ¹ （Affiliations ¹ College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People's Republic of China. ² UCL School of Pharmacy, University College London, London, WC1N 1AX, UK. ³ The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People's Republic of China. ⁴ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People's Republic of China.）

出处： International journal of nanomedicine 2025

关键词： Calcium ion load;anti-cancer;controlled-release nanomaterials;pH responsive drug release;reactive oxygen species;two-layer protective shell.

摘要： Background: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great p ...

作者： Ziwei Luo ^{#  1   2}, Chencen Lin ^{#  2   3}, Chuwei Yu  ⁴, Changxian Yuan  ³, Wenyong Wu  ⁴, Xiaowei Xu  ⁵, Renhong Sun  ⁶, Yan Jia  ⁴, Yafang Wang  ², Jie Shen  ⁷, Dingyan Wang  ⁴, Sinan Wang  ⁸, Hualiang Jiang  ^{1   2   9}, Biao Jiang  ^{1   2}, Xiaobao Yang  ⁶, Chengying Xie  ^{1   2   4} （Affiliations ¹ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. ² Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China. ³ School of Physical Science and Technology, ShanghaiTech University, Shanghai, China. ⁴ Lingang Laboratory, Shanghai, China. ⁵ Department of Hematology, Shanghai Jiao Tong University School of Medicine Affiliated Shanghai General Hospital, Shanghai, China. ⁶ Gluetacs Therapeutics (Shanghai) Co., Ltd., Shanghai, China. ⁷ Department of Pharmacy, The SATCM Third Grade Laboratory of Traditional Chinese Medicine Preparations, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. ⁸ School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China. ⁹ Drug Discovery and Development Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.）

出处： Cancer research 2025

摘要： Son of sevenless homolog 1 (SOS1) is an essential guanine nucleotide exchange factor for RAS that also plays a critical role in the activation of the ...

作者： Danling Cheng  ¹, Libai Luo  ², Qin Zhang  ³, Zheming Song  ⁴, Yiduo Zhan  ⁴, Wenzhi Tu  ⁵, Jingchao Li  ⁴, Qiming Ma  ⁶, Xianchang Zeng  ¹ （Affiliations ¹ Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, 310009, China. ² Oncology Chemotherapy Department, Affiliated Hospital of Youjiang Medical University for Nationalities and Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions, Baise, 533000, China. ³ Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China. ⁴ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China. ⁵ Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ⁶ Department of General Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： calcium overload;immunotherapy;radiodynamic therapy;second messengers;smart nanotherapeutic.

摘要： Various second messengers exert some vital actions in biological systems, including cancer therapy, but the therapeutic efficacy is often need to be i ...

作者： Yazhou Wu  ^{1   2   3   4   5}, Hanhua Li  ^{1   3   4   5}, Yin Long  ^{5   6}, Zhenzhen Zhang  ⁵, Fanping Zhang  ⁵, Runyu Pan  ^{1   3   4}, Leijun Meng  ^{1   3   4}, Zhan Ma  ^{1   3   4}, Kaijing Wang  ⁷, Bing Zheng  ², Zhonghong Qie  ⁸, Wei Gao  ⁹ （Affiliations ¹ Department of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ² Department of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Clinical Laboratory, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China. ⁶ Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Department of Hepatobiliary Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. ⁸ Department of Clinical Laboratory, Shanghai health and medical center, Wuxi, China. ⁹ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Molecular carcinogenesis 2025

关键词： RNF4;Wnt signaling pathway;colorectal cancer;epigenetic silencing;miR‐137.

摘要： Colorectal cancer (CRC) is a significant health issue worldwide. Recent studies highlight the critical role of miRNAs in CRC development, particularly ...

作者： Yufang Sun  ^{1   2}, Yu Tao  ², Junping Cao  ³, Yaqun Zhang  ², Zitong Huang  ², Shoupeng Wang  ², Weiwei Lu  ², Qi Zhu  ², Lidong Shan  ², Dongsheng Jiang  ^{4   5}, Yuan Zhang  ^{6   7   8}, Jin Tao  ^{9   7   8} （Affiliations ¹ Department of Geriatrics, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China. ² Department of Physiology and Neurobiology, Centre for Ion Channelopathy, Suzhou Medical College of Soochow University, Suzhou 215123, China. ³ Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, China. ⁴ Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ⁵ Institute of Regenerative Biology and Medicine, Helmholtz Zentrum München, Munich 81377, Germany. ⁶ Department of Geriatrics, Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China taoj@suda.edu.cn yuanzhang@suda.edu.cn. ⁷ Jiangsu Key Laboratory of Neuropsychiatric Diseases, Soochow University, Suzhou 215123, China. ⁸ MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou 215123, China. ⁹ Department of Physiology and Neurobiology, Centre for Ion Channelopathy, Suzhou Medical College of Soochow University, Suzhou 215123, China taoj@suda.edu.cn yuanzhang@suda.edu.cn.）

出处： The Journal of neuroscience : the official journal of the Society for Neuroscience 2025

关键词： histone methylation;miR-216a-3p;neuropathic pain;stromal interaction molecule 1;trigeminal ganglion neurons.

摘要： Although the therapeutic potential of microRNA-mediated gene regulation has been investigated, its precise functional regulatory mechanism in neuropat ...

作者： Mingyue Yao ^{#  1   2}, Wenzhong Yan ^{#  3}, Yafang Wang  ², Yu Zhao  ^{2   4}, Xiaowei Xu  ⁵, Yujun Chen  ^{2   4}, Chengcheng Yu  ¹, Yingnian Li  ¹, Hualiang Jiang  ^{2   4   6}, Jie Shen  ⁷, Jianjun Cheng  ^{8   9}, Chengying Xie  ^{10   11   12} （Affiliations ¹ Lingang Laboratory, 2380 Hechuan Road, Shanghai, 201101, China. ² Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, China. ³ iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China. ⁴ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. ⁵ Department of Hematology, Shanghai Jiao Tong University School of Medicine Affiliated Shanghai General Hospital, Shanghai, 200025, China. ⁶ Drug Discovery and Development Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. ⁷ Department of Pharmacy, The SATCM Third Grade Laboratory of Traditional Chinese Medicine Preparations, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai, 201203, China. shj421@126.com. ⁸ iHuman Institute, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, China. chengjj@shanghaitech.edu.cn. ⁹ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. chengjj@shanghaitech.edu.cn. ¹⁰ Lingang Laboratory, 2380 Hechuan Road, Shanghai, 201101, China. xiecy@lglab.ac.cn. ¹¹ Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, 201210, China. xiecy@lglab.ac.cn. ¹² School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. xiecy@lglab.ac.cn.）

出处： Experimental hematology & oncology 2025

关键词： Acute myeloid leukemia;DNA damage response;Drug resistance;FLT3-ITD mutation;HDAC inhibitor;Synergistic effect.

摘要： Background: Despite initial success with FLT3 inhibitors (FLT3is), outcomes for FLT3-ITD acute myeloid leukemia (AML) patients remain unsatisfactory, ...

作者： Zhu Xie ^{#  1}, Chao Li ^{#  1}, Rui Huang ^{#  2}, Bo Wu  ³, Qian Huang  ⁴, Zhe Zhang  ², Tongjin Zhao  ⁵, Lingqian Wu  ⁶, Chengtao Li  ⁷, Jianfeng Shen  ⁸, Hongyan Wang  ^{9   10} （Affiliations ¹ Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, 200438, China. ² Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Institute of Translational Medicine, National Facility for Translational Medicine, Shanghai JiaoTong University, Shanghai, 200240, China. ³ Prenatal Diagnosis Center of Shenzhen Maternity & Child Healthcare Hospital, Shenzhen, 518028, China. ⁴ Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200081, China. ⁵ Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, 200438, China. ⁶ Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics & Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Central South University, Changsha, 410078, China. ⁷ Shanghai Medical College, Fudan University, Shanghai, 200032, China. ⁸ Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Institute of Translational Medicine, National Facility for Translational Medicine, Shanghai JiaoTong University, Shanghai, 200240, China. jfshen@shsmu.edu.cn. ⁹ Obstetrics and Gynecology Hospital, State Key Laboratory of Genetic Engineering, Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai, 200438, China. wanghy@fudan.edu.cn. ¹⁰ Shenzhen Maternal and Child Health Hospital, Shenzhen, 518000, China. wanghy@fudan.edu.cn.）

出处： Cell death and differentiation 2025

摘要： The dysregulation of YAP activity is implicated in abnormal organ size and the pathogenesis of diverse diseases, including cancer. However, the functi ...

作者： Yilan Sheng  ^{1   2}, Jia Han  ¹ （Affiliations ¹ Shanghai University of Sport, Shanghai, China. ² Department of Rehabilitation, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China.）

出处： Journal of back and musculoskeletal rehabilitation 2025

关键词： cerebral blood oxygen level;cognitive-motor interference;functional near-infrared spectroscopy;single-dual-task walking-conversion training;stroke.

摘要： Background and purpose: This study aimed to explore the biomechanical characteristics of patients with stroke and neuromuscular action control mechani ...

作者： Fangjing Ni ^{#  1}, Xiangyin Tan ^{#  1}, Jian Zhang ^{#  2}, Tuanjie Guo  ¹, Zhihao Yuan  ¹, Xiang Wang  ³, Wenzhi Li  ⁴, Jialiang Shao  ⁵ （Affiliations ¹ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Urology, Shanghai Geriatric Medical Center, Shanghai, China. ³ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. seanw_hs@163.com. ⁴ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wenchihlee@sina.com. ⁵ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. jialiang.shao1@shgh.cn.）

出处： Clinical and experimental medicine 2025

关键词： Clear cell renal cell carcinoma;Glycogen metabolism;Immune infiltration;Molecular typing;Prognosis.

摘要： Glycogen accumulation is a typical feature in clear cell renal cell carcinoma (ccRCC). It has been reported that glycogen metabolism-related genes can ...

作者： Jingyi Zhou  ¹, Mengkai Yang  ², Weisong Zhao  ², He Zhang  ³, Lingling Cao  ⁴, Qi Li  ⁵, Gangyang Wang  ⁶ （Affiliations ¹ Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Orthopedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China. ³ Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan 450052, China. ⁴ Department of Rehabilitation, Shanghai Fifth Rehabilitation Hospital, Shanghai, China. Electronic address: caolingling1014@163.com. ⁵ Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: leeqi@sjtu.edu.cn. ⁶ Department of Orthopedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China. Electronic address: gangyang_wang@163.com.）

出处： Translational oncology 2025

关键词： Chemoresistance;HMGB1;lncRNA;miR-142-3p;osteosarcoma.

摘要： Background: Chemoresistance poses a significant challenge in the treatment of osteosarcoma (OS). Long non-coding RNAs (lncRNAs) have emerged as crucia ...