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作者: Tao Wang  1   2, Jing Lu  1, Rangrang Wang  1, Wanyue Cao  1, Junming Xu  1 (Affiliations 1 Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China. 2 Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.)

出处: Journal of Cancer 2022 Vol.13 No.2 P589-601

关键词: EMT;Hepatocellular carcinoma;TOP2A;cell cycle;miR-144-3p.

摘要: Topoisomerase II alpha (TOP2A) is an important nuclear protein which is found in various types of cancers. Whether TOP2A plays an important role in he ...

作者: Jun Wang  1, Jianhui Chen  2, Liren Jiang  3, Qi Wu  1   4, Dawei Wang  5 (Affiliations 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 2 Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China. 3 Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 4 Department of Urology, The Sixth Affiliated Hospital of Wenzhou Medical University (The People\'s Hospital of Lishui), Wenzhou, Zhejiang 323000, China. 5 Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.)

出处: Journal of oncology 2022 Vol.2022 P7693993

摘要: Purpose: Grade-dependent decrease of lipid storage in clear cell renal cell carcinoma (ccRCC) leads to morphology changes in HE sections. This study i ...

作者: Yufeng Ding  1, Jialiang Shao  2, Tiezhu Shi  2, Hua Yu  1, Xiang Wang  2, Honggang Chi  3, Xiongjun Wang  1 (Affiliations 1 School of Life Sciences, Guangzhou University, Guangzhou, China. 2 Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. 3 Department of Traditional Chinese Medicine, The First Dongguan Affiliated Hospital of Guangdong Medical University, Dongguan, China.)

出处: Clinical and translational medicine 2022 Vol.12 No.2 Pe676

摘要: Background: Prostate cancer (PCa), an inert tumour, has a long progression period, but valid biomarkers and methods for effectively and sensitively mo ...

作者: Yongang Li  1, Jiachen Gu  2, Youbing Mao  3, Xijia Wang  1, Zongshan Li  4, Xiaomin Xu  4, Huimin Chen  4, Yaxing Gui  5 (Affiliations 1 Department of Neurology, The First People\'s Hospital of Wenling, Wenling, China. 2 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.86 Wujin Road, Shanghai, 200080, China. 3 Department of Neuroelectrophysiology, The First People\'s Hospital of Wenling, Wenling, China. 4 Department of Neurology, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China. 5 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.86 Wujin Road, Shanghai, 200080, China. YaxingGui@shsmu.edu.cn.)

出处: Molecular neurobiology 2022

关键词: Autoimmune encephalitis (AE);Exosomes;Herpes simplex encephalitis (HSE);microRNAs.

摘要: Encephalitis mediated by autoantibodies against neuronal antigens and herpes simplex encephalitis (HSE) are seemingly separate causes of encephalopath ...

作者: Shanshan Hu  1, Shuowen Wang  1, Chendong Qi  1, Shengying Gu  1, Chenyang Shi  1, Lin Mao  1, Guorong Fan  1 (Affiliation 1 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Frontiers in pharmacology 2022 Vol.13 P831364

关键词: UKPDS OM;cost-utility analysis;dulaglutide;extended-release exenatide;once-weekly GLP-1 receptor agonist;subcutaneous semaglutide;type 2 diabetes.

摘要: Introduction: The substantial financial burden associated with type 2 diabetes (T2D) over a lifetime cannot be neglected. Therefore, the objective of ...

作者: Sijia He  1, Qi Li  1, Qian Huang  1, Jin Cheng  1 (Affiliation 1 Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.)

出处: Cancers 2022 Vol.14 No.5 P1104

关键词: cancer;cell death;protein kinase C;targeted therapy.

摘要: Protein kinase C (PKC) isoforms, a group of serine-threonine kinases, are important regulators in carcinogenesis. Numerous studies have demonstrated t ...

作者: Zhenghua Wu  1, Mengqi Jia  2, Wenjuan Zhao  3, Xucong Huang  4, Xinyi Yang  5, Dongxin Chen  6, Xijier Qiaolongbatu  7, Xiaojing Li  8, Jiaqi Wu  9, Feng Qian  10, Yuefen Lou  11, Guorong Fan  12 (Affiliations 1 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: wuzhenghua526@163.com. 2 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: 346852884@qq.com. 3 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: zhaowj@sjtu.edu.cn. 4 School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China. Electronic address: 1109060643@qq.com. 5 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: Xinyi2017@sjtu.edu.cn. 6 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: 770512829doudou@sjtu.edu.cn. 7 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: 962689538@qq.com. 8 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: l_xiaojing@yeah.net. 9 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: wjq731030@126.com. 10 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: fengqian@sjtu.edu.cn. 11 Department of Pharmacy, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200434, PR China. Electronic address: louyuefen@sina.cn. 12 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: fanguorong@sjtu.edu.cn.)

出处: Journal of ethnopharmacology 2022 Vol.289 P115031

关键词: Idiopathic pulmonary fibrosis;Network pharmacology;Schisandra chinensis;Schisandrol A;TGF-β signaling pathway;UPLC-Q-TOF/MS.

摘要: Ethnopharmacological relevance: Schisandra chinensis decoction derived from the book of Waitai Miyao (Tao Wang, Tang dynasty) is often used in the tre ...

作者: Xiaofeng Zhu #  1   2   3   4   5, Yi Xu #  1   2, Lina Lu  6   7, Haidong Zou  8   9   10   11   12 (Affiliations 1 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 4 National Clinical Research Center for Eye Diseases, Shanghai, China. 5 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. 6 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. lulina781019@qq.com. 7 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lulina781019@qq.com. 8 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. zouhaidong@sjtu.edu.cn. 9 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zouhaidong@sjtu.edu.cn. 10 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 11 National Clinical Research Center for Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 12 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn.)

出处: BMC health services research 2022 Vol.22 No.1 P160

关键词: Community health centers;Satisfaction;Telescreening;Vision-threatening diabetic retinopathy.

摘要: Background: The success of telescreening and the management of diabetic retinopathy (DR) in communities depends on stakeholder satisfaction, including ...

作者: Peng Li #  1, Zhiyong Ji #  1   2, Erlei Zhi  1, Yuxiang Zhang  1, Sha Han  1, Liangyu Zhao  1, Ruhui Tian  1, Huixing Chen  1, Yuhua Huang  1, Jing Zhang  3, Huirong Chen  1, Fujun Zhao  1, Zhi Zhou  4, Zheng Li  5, Chencheng Yao  6   7 (Affiliations 1 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 2 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211116, China. 3 The Reproductive Medicine Research Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510620, China. 4 School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. zhouzhi@shanghaitech.edu.cn. 5 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. lizhengboshi@sjtu.edu.cn. 6 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. yaochencheng@126.com. 7 School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. yaochencheng@126.com.)

出处: Reproductive biology and endocrinology : RB&E 2022 Vol.20 No.1 P21

关键词: MSH4;Male infertility;Meiosis;Non-obstructive azoospermia.

摘要: Background: Non-obstructive azoospermia (NOA) is one of the most severe type in male infertility, and the genetic causes of NOA with meiotic arrest re ...

作者: Xinran Qin  1, Haidong Zou  2   3   4   5   6 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zouhaidong@sjtu.edu.cn. 3 Shanghai Eye Diseases Prevention & Treatment Center, Shanghai Eye Hospital, Shanghai, China. zouhaidong@sjtu.edu.cn. 4 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 5 National Clinical Research Center for Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 6 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn.)

出处: BMC ophthalmology 2022 Vol.22 No.1 P86

关键词: Blood-retina barrier;Diabetic retinopathy;Dysbiosis;Gut leakage;Inflammation;Lipopolysaccharides;Retinal glia.

摘要: Diabetes mellitus (DM) is a complex metabolic syndrome characterized by hyperglycemia. Diabetic retinopathy (DR) is the most common complication of DM ...

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