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作者: Jingjing Jiang  1, Ru Cheng  1, Aoqi Song  1, Yuefen Lou  2, Guorong Fan  3 (Affiliations 1 Department of Pharmacy, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China. 2 Department of Pharmacy, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China. louyuefen@sina.cn. 3 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. fanguorong@sjtu.edu.cn.)

出处: Functional & integrative genomics 2024

关键词: Acteoside;Epithelial-mesenchymal transition;Extracellular regulated kinases 1/2 pathway;Liver cancer;Schisandra chinensis lignans.

摘要: Background: Hepatocellular carcinoma (HCC), a globally common cancer, often presents late and shows high resistance to chemotherapy, resulting in subo ...

作者: Rui Guo  1   2, Biao Ding  3, Kaiqin Hu  1   2, Kai Wang  1   2, Dongdong Tang  2, Xuegu Wang  3, Junpei Sun  3, KuoKuo Li  1   2, Huiru Cheng  1   2, Chuan Xu  2, Miao Sun  4, Likui Lu  2, Mingxi Liu  5, Yunxia Cao  1   2, Xiaoyu Yang  6, Xiaojin He  1   7 (Affiliations 1 NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui, China. 2 Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. 3 Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China. 4 Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, China. 5 State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China. 6 State Key Laboratory of Reproductive Medicine, The Center for Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 7 Department of Obstetrics and Gynecology, Reproductive Medicine Center, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.)

出处: Andrology 2024

关键词: TDRD5 variants;oligoasthenoteratozoospermia;pirna;spermiogenesis;whole exome sequencing.

摘要: Background: PiRNA pathway factors, including evolutionarily conserved Tudor domain-containing proteins, play crucial roles in suppressing transposons ...

作者: Chuanhe Jiang  1, Jingtao Huang  1, Jie Shao  2, Tingting Yang  3, Ye Zhao  4, Meijuan Huang  5, Hongmei Yi  6, Jimin Shi  3, Liping Wan  2, Feng Chen  4, Yang Cao  5, Xiaoxia Hu  1 (Affiliations 1 Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 4 National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. 5 Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 6 Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Cell transplantation 2024

关键词: EBV;T-PTLD;allo-HSCT;poor prognosis.

摘要: Posttransplant lymphoproliferative disorder (PTLD) is a rare lymphoid and/or plasmocytic proliferation that occurs after allogeneic hematopoietic stem ...

作者: Feng Gao #  1, Liren Jiang #  1, Tuanjie Guo #  2, Jun Lin #  1, Weiqing Xu #  1, Lin Yuan  1, Yaqin Han  1, Jiji Yang  1, Qi Pan  2, Enhui Chen  3, Ning Zhang  4, Siteng Chen  5, Xiang Wang  6 (Affiliations 1 Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Pathology, Dongtai People's Hospital, Dongtai, Jiangsu, China. 4 Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zn12235@rjh.com.cn. 5 Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. siteng@sjtu.edu.cn. 6 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xiang.wang1@shgh.cn.)

出处: Journal of translational medicine 2024

关键词: Deep learning;Lymph node metastasis;Prognosis;Renal cell carcinoma;Whole slide images.

摘要: Background: Metastasis renal cell carcinoma (RCC) patients have extremely high mortality rate. A predictive model for RCC micrometastasis based on pat ...

作者: Yan Ma #  1   2, Ying Zhang #  2, Hui-Ying Zhang  1   2, Ya Zhao  3, Xiu-Miao Li  2, Yi-Fei Jiang  2, Mu-Di Yao  4, Qin Jiang  5   6, Biao Yan  7 (Affiliations 1 The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. 2 The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. 3 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 4 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. mudiyao@163.com. 5 The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. jiangqin710@126.com. 6 The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. jiangqin710@126.com. 7 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. yanbiao@sjtu.edu.cn.)

出处: Journal of translational medicine 2024

关键词: Anti-angiogenic therapy;Exosomal formulation;Ocular vascular disease;Transfer RNA-derived fragment.

摘要: Background: Intravitreal injections of angiogenesis inhibitors have proved efficacious in the majority of patients with ocular angiogenesis. However, ...

作者: Yiyang Wang  1   2, Yunyan Ye  3, Shengyi Shi  3, Kehang Mao  1, Haonan Zheng  1, Xuguang Chen  3, Hanting Yan  3, Yiming Lu  3   4   5, Yong Zhou  6, Weimin Ye  7   8, Jing Ye  3   4   5, Jing-Dong J Han  1   9 (Affiliations 1 Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, China. 2 Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. 3 Emergency Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Geriatrics, International Laboratory in Hematology and Cancer, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Hospital/CNRS/Inserm/Cote d'Azur University, Shanghai, China. 5 The State Key Laboratory of Medical Genomics, Pole Sino-Francais de Recherche en Sciences Du Vivant et Genomique, Shanghai, China. 6 Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 7 School of Public Health, Fujian Medical University, Fuzhou, China. 8 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. 9 Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Chengdu, China.)

出处: Aging cell 2024

关键词: aging;diagnosis model;facial images;stroke.

摘要: Stroke is a major threat to life and health in modern society, especially in the aging population. Stroke may cause sudden death or severe sequela-lik ...

作者: Jingwen Zhou #  1, Chunyan He #  2, Han Yang  2, Wen Shu  2, Qingzhong Liu  3 (Affiliations 1 Department of Clinical Laboratory, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Rd, Shanghai, 200071, People's Republic of China. 2 Department of Clinical Laboratory, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 3 Department of Clinical Laboratory, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Rd, Shanghai, 200071, People's Republic of China. jiaodamedicine@foxmail.com.)

出处: BMC microbiology 2024

关键词: Staphylococcus aureus;Genomics;Metabolomics;Small colony variant;Sulfamethoxazole-trimethoprim;Transcriptomics.

摘要: Background: Long-term treatment with trimethoprim-sulfamethoxazole (SXT) can lead to the formation of small-colony variants (SCVs) of Staphylococcus a ...

作者: Lihao Zhang  1, Lehao Ren  2, Yufei Chen  1, Yue Cao  1, Sunlong Li  1, Weipeng Lu  1, Yaoyuan Jia  1, Yachun Li  3, Cihui Liu  1, Chen Li  4, Qian Dong  5   6   7 (Affiliations 1 Center for Future Optoelectronic Functional Materials, School of Computer and Electronic Information/School of Artificial Intelligence, Nanjing Normal University, Nanjing, China. 2 Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. 3 Department of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201601, China. 4 School of Electronic Science and Engineering, Southeast University, Nanjing, 210096, China. 5 Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 6 Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 7 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine. Shanghai Jiao Tong University, Shanghai, China.)

出处: Advanced healthcare materials 2024

关键词: bioinspired;cervical canal stent;colloidal crystals hydrogel;stimulus‐responsive;wettability.

摘要: Soft-bodied aquatic organisms have exhibited remarkable capabilities in navigating and moving within liquid environments serving as a profound inspira ...

作者: Ying Zeng #  1, Meng-Lan Sun #  1, Di Liu #  2, Yue Huang  1, Shan Xie  1, Ya-Xuan Zhao  1, Zi-Xuan Wu  1, Ya Liu  1, Gan Ma  1, Ling Xie  1, Yu-Tao Dang  1, Ling-Yun Hao  1, Qi-Hui Wang  1, Hong-Jun Wang  1, Li Yang  1, Zhou-Ya Xue  3   4, Zhi-Qiang Pan  5 (Affiliations 1 Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Tong Shan Road no. 209, Xuzhou, 221004, Jiangsu Province, China. 2 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Tong Shan Road no. 209, Xuzhou, 221004, Jiangsu Province, China. xuezhouya@163.com. 4 Department of Anesthesiology, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng, Yancheng, 224008, China. xuezhouya@163.com. 5 Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Tong Shan Road no. 209, Xuzhou, 221004, Jiangsu Province, China. zhiqiangp2002@aliyun.com.)

出处: Molecular neurobiology 2024

关键词: Chronic inflammatory pain;Dorsal spinal horn;Kv3.1;Peptide interference;UBR5.

摘要: Chronic inflammatory pain caused by neuronal hyperactivity is a common and refractory disease. Kv3.1, a member of the Kv3 family of voltage-dependent ...

作者: Deping Kong #  1   2, Jing Liu #  1, Junmi Lu #  3, Cheng Zeng #  1, Hao Chen  1, Zhenzhen Duan  2, Ke Yu  4, Xialei Zheng  1, Pu Zou  1, Liufang Zhou  1   5, Yicheng Lv  2, Qingye Zeng  2, Lin Lu  6, Jiang Li  1, Yuhu He  1 (Affiliations 1 Departments of Cardiology (D.K., J. Liu, C.Z., H.C., X.Z., P.Z., L.Z., J. Li, Y.H.), The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. 2 Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital (D.K., Z.D., Y.L., Q.Z.), Shanghai Jiao Tong University School of Medicine, China. 3 Pathology (J. Lu), The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. 4 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Guangdong, China (K.Y.). 5 Department of Cardiovascular Medicine, The Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi, China (L.Z.). 6 Department of Cardiology, Rui Jin Hospital (L.L.), Shanghai Jiao Tong University School of Medicine, China.)

出处: Arteriosclerosis, thrombosis, and vascular biology 2024

关键词: biomarkers;cell proliferation;hypertension, pulmonary;hypoxia;myocytes, smooth muscle.

摘要: Background: Pulmonary hypertension (PH) is a progressive and life-threatening disease characterized by pulmonary vascular remodeling, which involves a ...

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