作者： Yihui Wang;Jizheng Wang;Ling Shi;Xiuyu Chen;Desheng Li;Chen Cui;Kai Yang;Minjie Lu;Jinhua Huang;Lei Zhang;Fei Li;Jinxi Wang;Biyi Chen;Bin Wang;Duane D Hall;Zhenwei Pan;Jiang Hong;Long-Sheng Song;Lei Song;Shihua Zhao （Affiliations ¹ Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, China (Y.W., J. Hong). ² State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (Y.W., Jizheng Wang, X.C., C.C., K.Y., M.L., L.Z., F.L., L.S., S.Z.). ³ Department of Pharmacology, College of Pharmacy, and State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, China (L.S., D.L., Z.P.). ⁴ Department of Cardiology, Fujian Medical University Union Hospital, Fujian Institute of Coronary Heart Disease, China (J. Huang). ⁵ Division of Cardiovascular Medicine, Department of Internal Medicine, Abboud Cardiovascular Research Center (Jinxi Wang, B.C., D.D.H., L.-S.S.), Carver College of Medicine, University of Iowa, Iowa City. ⁶ Department of Cardiology, the First Affiliated Hospital of Shantou University Medical College, Guangdong, China (B.W.). ⁷ Department of Biochemistry and Molecular Biology (L.-S.S.), Carver College of Medicine, University of Iowa, Iowa City. ⁸ Fraternal Order of Eagles Diabetes Research Center (L.-S.S.), Carver College of Medicine, University of Iowa, Iowa City. ⁹ Department of Veterans Affairs Medical Center, Iowa City, IA (L.-S.S.).）

出处： Circulation 2023

关键词： atrial fibrillation;atrial myopathy;calcineurin;calcium and integrin binding 1 (CIB1);calcium and integrin binding 2 (CIB2);fibrosis.

摘要： Background: Atrial fibrillation (AF) is a highly prevalent condition that can cause or exacerbate heart failure, is an important risk factor for strok ...

作者： Jingxiao Du;Tianwei Qian;Yi Lu;Wenkai Zhou;Xun Xu;Chaoyang Zhang;Jingfa Zhang;Zhihua Zhang （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: chaoyang.zhang@shgh.cn. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: 13917311571@139.com. ⁴ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: drzhihuazhang@126.com.）

出处： Experimental cell research 2023

关键词： Extracellular matrix;Fibroblast;Glaucoma;SPARC;YAP;α-SMA.

摘要： Background: Fibrotic scar is a severe side effect of trabeculectomy, resulting in unsatisfactory outcomes for glaucoma surgery. Accumulating evidence ...

作者： Menghao Sun;Yuanhao Shen;Gaozhen Jia;Zheng Deng;Fei Shi;Yifeng Jing;Shujie Xia （Affiliations ¹ Clinical Medical Center of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Institute of Urology, Shanghai Jiao Tong University, Shanghai, China. ³ Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Journal of Cancer 2023

关键词： FRMD6;HNRNPA2B1;Prostate cancer;m6A;miR-93-5p.

摘要： It is becoming increasingly clear that N6-methyladenosine (m6A) plays a key role in post-transcriptional modification of eukaryotic RNAs in cancer. Th ...

作者： Jiang Du;Dan Zhang;Jie Xie;Liu Wang;Yun Xie;Daonan Chen;Xiaoyin She;Jiang Hong;Ruilan Wang （Affiliations ¹ Emergency & Critical Care Department, Shanghai General Hospital of Shanghai Jiaotong University School of Medicine, 650 Xin Songjiang Rd, Shanghai, China. gowindj@163.com. ² Emergency & Critical Care Department, Shanghai General Hospital Jiading Branch of Shanghai Jiaotong University School of Medicine, 800 Huangjiahuayuan RD, 650 Xin Songjiang Rd, Shanghai, China. gowindj@163.com. ³ Emergency & Critical Care Department, Shanghai General Hospital of Shanghai Jiaotong University School of Medicine, 650 Xin Songjiang Rd, Shanghai, China. ⁴ Emergency & Critical Care Department, Shanghai General Hospital Jiading Branch of Shanghai Jiaotong University School of Medicine, 800 Huangjiahuayuan RD, 650 Xin Songjiang Rd, Shanghai, China. ⁵ Emergency & Critical Care Department, Shanghai General Hospital Jiading Branch of Shanghai Jiaotong University School of Medicine, 800 Huangjiahuayuan RD, 650 Xin Songjiang Rd, Shanghai, China. 18917444639@163.com. ⁶ Emergency & Critical Care Department, Shanghai General Hospital of Shanghai Jiaotong University School of Medicine, 650 Xin Songjiang Rd, Shanghai, China. jhong.pku@163.com.）

出处： Internal and emergency medicine 2023

关键词： Acute kidney injury;Acute renal failure;Body mass index;Obesity;Rehydration volume;Survival.

摘要： Rehydration volume may be underestimated in obese critically ill patients, which can lead to acute kidney injury (AKI). This study aimed to investigat ...

作者： Jiawei Lu;Lanting Yu;Ni Xie;Ying Wu;Baiwen Li （Affiliation ¹ Department of Gastroenterology, Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.）

出处： Journal of Cancer 2023

关键词： IGF2BP2;LINC00941;METTL14;N6-methyladenosine;metastasis;pancreatic carcinoma.

摘要： Pancreatic adenocarcinoma (PC), one of the most fatal diseases, usually generates a poor prognosis in advanced stages. N6-methyladenosine modification ...

作者： Chao Xia;Yonghui Wang;Tianyuan Jiang;Yan Hu;Yang Chen;Xinrun Ma;Xuemei Zhang;Yanhong Gao （Affiliations ¹ Department of Geriatrics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Geriatrics, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.）

出处： Journal of cachexia, sarcopenia and muscle 2023

关键词： Muscle regeneration;Myoblast;Myogenesis;Skeletal muscle;Slo1;Slow-twitch fibre formation.

摘要： Background: It has been observed that Slo1 knockout mice have reduced motor function, and people with certain Slo1 mutations have movement problems, b ...

作者： Jian Lin;Zhanjun Lu;Gengfeng Li;Cui Zhang;Huiying Lu;Sheng Gao;Ruixin Zhu;Hailiang Huang;Konrad Aden;Jianhua Wang;Yingzi Cong;Huili Wu;Zhanju Liu （¹Department of Gastroenterology, Shanghai Tenth People’s Hospital of Tongji University School of Medicine, Shanghai, China;²Department of Gastroenterology, Affiliated Hospital of Putian University, Putian, China;³Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, China;⁵Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA;⁶Department of Internal Medicine I, Institute of Clinical Molecular Biology, Christian-Albrechts-University, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany;⁷Storr Liver Unit, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia;⁸Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA;⁹Department of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China）

出处： Journal of Innate Immunity 2023

关键词： MCPIP-1;Neutrophils;Acute bacterial peritonitis;Liver injury;Bacterial infection

摘要： Monocyte chemotactic protein-1-induced protein-1 (MCPIP-1) is highly expressed in activated immune cells and negatively regulates immune responses, wh ...

作者： Aoyuan Fan;Genbin Wu;Jianfang Wang;Laiya Lu;Jingyi Wang;Hanjing Wei;Yuxi Sun;Yanhua Xu;Chunyang Mo;Xiaoying Zhang;Zhiying Pang;Zhangyi Pan;Yiming Wang;Liangyu Lu;Guojian Fu;Mengqiu Ma;Qiaoling Zhu;Dandan Cao;Jiachen Qin;Feng Yin;Rui Yue （¹Department of Joint Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200092, China;²Department of Orthopedic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, China;³Institute for Regenerative Medicine, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China;⁴Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, China;⁵Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai, 200120, China;⁶Shanghai Clinical Research Center for Aging and Medicine, Shanghai, 200040, China）

出处： Bone Research 2023

摘要： Fibroblast activation protein (Fap) is a serine protease that degrades denatured type I collagen, α2-antiplasmin and FGF21. Fap is highly expressed in ...

作者： Hongmiao Wang;Huixun Jia;Yang Gao;Haosong Zhang;Jin Fan;Lijie Zhang;Fandong Ren;Yandong Yin;Yuping Cai;Ji Zhu;Zheng-Jiang Zhu （¹Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, China;²University of Chinese Academy of Sciences, Beijing, 100049, China;³Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;⁴Department of Biostatistics, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;⁵Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, 310005, China;⁶Institute of Cancer and Basic Medicine, Chinese Academy of Sciences, Hangzhou, 310000, China;⁷Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, 310000, China;⁸Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China;⁹Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200031, China;¹⁰Shanghai Key Laboratory of Radiation Oncology, Shanghai, 200032, China;¹¹Shanghai Key Laboratory of Aging Studies, Shanghai, 201210, China）

出处： Nature Communications 2023

作者： Fangfei Zhang;Jianyong Yin;Li Liu;Shuiying Liu;Guangyuan Zhang;Yiwei Kong;Yajun Wang;Niansong Wang;Xiangmei Chen;Feng Wang （Affiliations ¹ Department of Rheumatology, Immunology and Allergy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address: yinjianyong09@163.com. ³ Department of Urology, Zhongda Hospital, Southeast University, Nanjing, China. ⁴ Biomedical School, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. ⁵ Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. ⁶ State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing, China. ⁷ Department of Rheumatology, Immunology and Allergy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: zyzwq1030@hotmail.com.）

出处： EBioMedicine 2023

关键词： Acute kidney injury;Diabetic nephropathy;IL-17C;Ischemia/reperfusion injury.

摘要： Background: Interleukin-17C (IL-17C), a member of the IL-17 cytokine family, plays a pathogenic role in kidney diseases. Our previous studies have sho ...