作者： Andrew Chang  ¹, Xiaodong Sun  ², Tomohiro Iida  ³, Timothy Y Y Lai  ⁴, Tien Y Wong  ⁵, Chui Ming Gemmy Cheung  ⁶, Won Ki Lee  ⁷, Xin Zhang  ⁸, Andrea Schulze  ⁹, Ursula Maria Schmidt-Ott  ⁹, Min Zhao  ¹⁰, Zoran Hasanbasic  ¹¹, Sergio Leal  ¹¹, Shih-Jen Chen  ¹²; PULSAR study investigators （Affiliations ¹ Sydney Retina Clinic, Sydney, NSW, Australia. Electronic address: achang@sydneyretina.com.au. ² Shanghai General Hospital, Shanghai, China. ³ Department of Ophthalmology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan. ⁴ Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. ⁵ Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Beijing Visual Science and Translational Eye Research Institute (BERI), Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. ⁶ Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Duke-NUS Medical School, National University of Singapore, Singapore, Singapore. ⁷ Nune Eye Hospital, Gangnam District, Seoul, Republic of Korea. ⁸ Bayer Consumer Care AG, Basel, Switzerland. ⁹ Bayer AG, Berlin, Germany. ¹⁰ Bayer Healthcare Co. Ltd., Beijing, China. ¹¹ Bayer Australia Ltd., Pymble, NSW, Australia. ¹² Department of Ophthalmology, Taipei Veterans General Hospital, Taipei City, Taiwan; National Yang Ming Chiao Tung University, Taipei City, Taiwan.）

出处： Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2026

关键词： Asian population;PULSAR;aflibercept 8mg;intraocular pressure;neovascular age-related macular degeneration.

摘要： Purpose: To evaluate 1-year efficacy and safety of aflibercept 8mg in Asian patients with neovascular age-related macular degeneration (nAMD) in the P ...

作者： Hanyuan Liu^1,2;Jinxin Huang³;Zixuan Wang^4,5;Nuofan Wang⁶;Xiaopei Hao⁷;Yue Chai¹;Na Yu⁸;Hengsong Cao¹;Yanshu He¹;Shipeng Dai¹;Jintao Xu⁹;Zongkang Zhang⁹CA1;Jie Kong¹⁰CA2;Fei Xiong³CA3;Weiwei Tang¹CA4;Jinhua Song^1,11CA5 （¹Key Laboratory of Liver Transplantation, Chinese Academy of Medical Sciences, NHC Key Laboratory of Living Donor Liver Transplantation, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;²Center of Interventional Radiology and Vascular Surgery, Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China;³State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210029, China;⁴Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Nanjing 210000, China;⁵Postgraduate College, Nanjing Medical University, Nanjing 210029, China;⁶Department of Hepato-Pancreatico-Biliary Surgery, Zhongda Hospital Southeast University, Nanjing 210009, China;⁷Department of Hepatobiliopancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou 450000, China;⁸Department of Pharmaceutical Preparation, General Hospital of Ningxia Medical University, Yinchuan 750004, China;⁹School of Chinese Medicine, Chinese University of Hong Kong, Hong Kong 518172, China;¹⁰Department of Intervention, Nanjing First Hospital, Nanjing Medical University, Nanjing 210000, China;¹¹Department of Interventional Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China）

出处： ACS Applied Materials & Interfaces 2026

关键词： transarterial chemoembolization;KN035;microspheres;hepatocellular carcinoma;myeloid-derived suppressor cells

摘要： High Resolution Image Download MS PowerPoint Slide Transarterial chemoembolization (TACE) remains a cornerstone locoregional therapy for hepatocellula ...

作者： Min Tang ¹, Binle Tian ¹, Jingyi Zhou ¹, Di Ma ¹, Rongze Sun ¹, Qi Li ¹ （Affiliation ¹ Department of Medical Oncology, Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Cancer medicine 2026

关键词： KLF4;cancer;immune cells;tumor microenvironment.

摘要： Objective: Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays context-dependent roles in cancer. It functions as either a t ...

作者： Jinchun Wu ^{# 1 2}, Jingjing Cao ^{# 1}, Lu Gao ¹, Min Yang ¹, Jie Shao ¹, Ying Zhang ¹, Xiaowei Xu ¹, Yu Cai ¹, Yu Wei ¹, Xianmin Song ³, Liping Wan ⁴ （Affiliations ¹ Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Hongkou District, Shanghai, 200080, China. ² Department of Hematology, Qingpu Branch, Zhongshan Hospital, Fudan University, Shanghai, China. ³ Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Hongkou District, Shanghai, 200080, China. shongxm@sjtu.edu.cn. ⁴ Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Hongkou District, Shanghai, 200080, China. lipingwan@sjtu.edu.cn.）

出处： Annals of hematology 2026

关键词： Acute lymphoblastic leukemia;Inotuzumab ozogamicin;Portal hypertension;Sinusoidal obstruction syndrome/Veno-occlusive disease (SOS/VOD).

摘要： Inotuzumab ozogamicin (InO) is effective for relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) but is associated with hepatotoxicity ...

作者： Jiangfeng Hu ¹, Xingya Guo ¹, Weiliang Jiang ^{# 1}, Xiaobo Cai ^{# 1} （Affiliation ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.）

出处： Endoscopy 2026

作者： Zuolin Ying ¹, Xiaojie Li, Na Yin, Chuang Gao （Affiliation ¹ Department of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Medicine 2026

关键词： cardiovascular diseases;long-term health;neurological diseases;syphilis.

摘要： Syphilis, caused by Treponema pallidum, remains a significant public health concern globally. While early treatment can prevent the acute effects, syp ...

作者： Zilin Wang ^{1 2 3 4}, Junran Sun ^{1 2 3 4}, Kun Liu ^{1 2 3 4}, Liming Tao ⁵, Qinghuai Liu ⁶, Miaoqin Wu ⁷, Shujie Lu ⁸, Junjie Deng ⁸, Li Li ⁸, Lei Qian ⁸, Xiaorong Li ⁹, Xiaodong Sun ^{10 2 3 4} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² National Clinical Research Center for Ophthalmic Diseases, Shanghai, China. ³ Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. ⁴ Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. ⁵ Department of Ophthalmology, The Second Hospital of Anhui Medical University, Hefei, Anhui, China. ⁶ Department of Ophthalmology, Jiangsu Province Hospital, Nanjing, Jiangsu, China. ⁷ Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China. ⁸ Innovent Biologics Suzhou Co Ltd, Suzhou, Jiangsu, China. ⁹ Tianjin Medical University Eye Hospital, Tianjin, China xdsun@sjtu.edu.cn xiaorli@163.com. ¹⁰ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China xdsun@sjtu.edu.cn xiaorli@163.com.）

出处： BMJ open ophthalmology 2026

关键词： Macula.

摘要： Objective: To evaluate the safety, tolerability and preliminary efficacy of IBI324, a vascular endothelial growth factor-A/angiopoietin-2 bispecific a ...

作者： Yixuan Jiang ^{1 2}, Zhengyu Guan ^{1 2}, Xiu Yao ^{3 4}, Xiaomeng Liu ¹, Dan Qiu ⁵, Boyuan Sun ^{1 2}, Hongjiao Li ¹ （Affiliations ¹ Department of Stomatology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. ² Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China. ⁴ School of Stomatology, Fudan University, Shanghai, China. ⁵ School of Stomatology, Ningxia Medical University, Yinchuan, Ningxia, China.）

出处： Journal of periodontal research 2026

关键词： Mendelian randomization;chronic periodontitis;drug target;osteoclast.

摘要： Aim: Periodontitis currently lacks effective treatments to halt disease progression, as existing therapies focus solely on symptom management. Drug re ...

作者： Wu Ye ¹, Yigang Li ¹, Wei Wang ², Dishui Pan ¹, Xiaokun Wang ¹, Yao Gu ¹, Yufeng Zhu ¹, Haofan Wang ¹, Xuanyu Lu ¹, Dongdong Jiang ³, Pengyu Tang ¹, Haoming Shu ⁴, Jun Ma ⁴, Weihua Cai ¹ （Affiliations ¹ Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu, China. ² Department of Stress Medicine, Faculty of Psychology, Naval Medical University, Shanghai 200433, China. ³ Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China. ⁴ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.）

出处： International journal of biological sciences 2026

关键词： NEDD4;YAP1;chaperone-mediated autophagy;reactive astrogliosis;ubiquitination.

摘要： Following spinal cord injury (SCI), the transcriptional regulator yes-associated protein 1 (YAP1) is upregulated and accumulates in the nuclei of astr ...

作者： Lianghua Shen ¹, Ziyu Chen ¹, Jian Xu ¹, Qiaomei He ¹, Changmeng Zhang ¹, Xiao Zhou ¹, Xiaodan Ding ¹, Jinan Fang ¹, Fanlin Li ¹, Ming Jiao ¹, Yuqin Yang ¹, Baoxia Dong ¹, Liping Wan ¹, Xueying Ding ², Yan Zheng ³, Jingyi Zhou ⁴, Chijian Zuo ⁵, Tian Min ⁶, Ming Zhu ⁶, Bin Ma ⁶, Yuhua Wan ⁷, Qiufang Guo ⁷, Hua Zhang ⁷, Jian Hua ⁷, Pengran Wang ¹, Qi Li ⁴, Jiang Long ³, Xianmin Song ¹, Yan Zhang ¹ （Affiliations ¹ Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Engineering Technology Research Center of Cell Therapy and Clinical Transla, Science and Technology Committee of Shanghai Municipality, Shanghai, China. ³ Department of Pancreatic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Suzhou CureMed Biopharma Technology Co., Ltd., Suzhou, China. ⁶ KuaiXu Biotechnologies Co., Ltd., Shanghai, China. ⁷ SPH Biotherapeutics (Shanghai) Co., Ltd., Shanghai, China.）

出处： The Journal of clinical investigation 2026

关键词： Cancer immunotherapy;Immunology;Oncology;p53.

摘要： Malignant tumors with TP53 mutations exhibit poor therapeutic outcomes and high recurrence rates. T cell receptor (TCR)-based T cell therapy shows gre ...