作者： Di Cui;Jianneng Li;Ziqi Zhu;Michael Berk;Aimalie Hardaway;Jeffrey McManus;Yoon-Mi Chung;Mohammad Alyamani;Shelley Valle;Ritika Tiwari;Bangmin Han;Maryam Goudarzi;Belinda Willard;Nima Sharifi （Affiliations ¹ Genitourinary Malignancies Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA. ² Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Metabolomics Shared Laboratory Resource, Lerner Research Institute. ⁴ Department of Urology, Glickman Urological and Kidney Institute, and. ⁵ Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.）

出处： The Journal of clinical investigation 2023

关键词： Oncology;Prostate cancer;Sex hormones.

摘要： After androgen deprivation, prostate cancer frequently becomes castration resistant (CRPC), with intratumoral androgen production from extragonadal pr ...

作者： Zhenyang Shen;Weiming Dai;Yuecheng Guo;Junjun Wang;Bo Shen;Binghang Li;Lungen Lu;Xiaobo Cai （Affiliations ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023

关键词： Yes-associated protein;ductular reaction;liver fibrosis;liver progenitor cells;transplantation.

摘要： Liver fibrosis is closely related to the proliferation and differentiation of liver progenitor cells (LPCs). Yes-associated protein (YAP) is a key eff ...

作者： Jifu Ge;Weikang Pan;Noel J Feeney;Leah Ott;Emily Anderson;Alessandro Alessandrini;Ivan Zanoni;James F Markmann;Alex G Cuenca （Affiliations ¹ Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China. ² Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA. ³ Massachusetts General Hospital, Division of Transplant Surgery, Department of Medicine, Boston, MA 02114, USA. ⁴ Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, MA 02114, USA; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. USA. ⁵ Department of Medicine, Division of Gastroenterology/Immunology, Boston Children's Hospital, Boston, MA 02115, USA. ⁶ Massachusetts General Hospital, Division of Transplant Surgery, Department of Medicine, Boston, MA 02114, USA; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, MA 02114, USA. ⁷ Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, MA 02114, USA. Electronic address: alex.cuenca@childrens.harvard.edu.）

出处： American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023

摘要： Advances in immunosuppression have been relatively stagnant over the last 2 decades and transplant recipients continue to experience long term morbidi ...

作者： Y X Qian;S Y Liu;X J Wang;S J Xia （Affiliation ¹ Department of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Institute of Urology, Shanghai Jiao Tong University, Shanghai 200080, China.）

出处： Zhonghua yi xue za zhi 2023

摘要： Benign prostatic hyperplasia (BPH) is one of the most common diseases in elderly men. Transurethral resection of prostate (TURP), as an important BPH ...

作者： Hui-Yi Li;Seng-Wang Fu;Jun-Cheng Wu;Zheng-Hong Li;Ming-Yi Xu （Affiliations ¹ Department of Gastroenterology, School of Medicine, Shanghai East Hospital, Tongji University, No. 1800, Yuntai Rd, Shanghai, 310115, China. ² Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of Gastroenterology, The Third Affiliated Hospital of Soochow University, Changzhou, 213000, Jiangsu Province, China. ⁴ Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665, Kongjiang Rd, Shanghai, 200092, China. lee0072312@163.com. ⁵ Department of Gastroenterology, School of Medicine, Shanghai East Hospital, Tongji University, No. 1800, Yuntai Rd, Shanghai, 310115, China. angela752022@163.com.）

出处： Inflammation research : official journal of the European Histamine Research Society ... 2023

关键词： KCs, Kupffer cells;Macrophages;NASH, Non-alcoholic steatohepatitis;Vsig4, V-set and immunoglobulin domain-containing 4;scRNA-seq, Single-cell RNA sequencing.

摘要： Background: The role of macrophages in the pathogenesis of nonalcoholic steatohepatitis (NASH) is complex and unclear. Methods: Single-cell RNA sequen ...

作者： Z Y Qi  ¹, J Chen  ¹, X G He  ¹ （Affiliation ¹ Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Division of Ophthalmology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 201103, China.）

出处： [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2023

摘要： Myopia, especially high myopia, seriously affects the children and adolescents' quality of learning and life relating to a series of eye diseases. Mor ...

作者： Luca Giovanni Locatello ^{#  1   2   3}, Serena Jiang ^{#  1}, Lixiao Chen  ³, Saverio Caini  ⁴, Giandomenico Maggiore  ¹, Pin Dong  ³, Oreste Gallo  ^{5   6} （Affiliations ¹ Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy. ² Department of Otorhinolaryngology, University Hospital "Santa Maria Della Misericordia", Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy. ³ Department of Otolaryngology-Head & Neck Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China. ⁴ Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. ⁵ Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy. oreste.gallo@unifi.it. ⁶ Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. oreste.gallo@unifi.it.）

出处： European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2023

关键词： Adjuvant radiotherapy;Functional outcomes;Laryngeal cancer;Laryngeal surgery;OPLS;PORT;Partial laryngectomy.

摘要： Background: The oncological and functional role of postoperative radiotherapy (PORT) after open partial laryngeal surgery (OPLS) remains debatable. Me ...

作者： Dan-Qin Sun ^{#  1   2}, Giovanni Targher ^{#  3}, Christopher D Byrne ^{#  4}, David C Wheeler  ⁵, Vincent Wai-Sun Wong  ⁶, Jian-Gao Fan  ⁷, Herbert Tilg  ⁸, Wei-Jie Yuan  ⁹, Christoph Wanner  ¹⁰, Xin Gao  ¹¹, Michelle T Long  ¹², Mehmet Kanbay  ¹³, Mindie H Nguyen  ^{14   15}, Sankar D Navaneethan  ¹⁶, Yusuf Yilmaz  ^{17   18}, Yuli Huang  ¹⁹, Rino A Gani  ²⁰, Pierluigi Marzuillo  ²¹, Jérôme Boursier  ^{22   23}, Huijie Zhang  ²⁴, Chan-Young Jung  ²⁵, Jin Chai  ²⁶, Luca Valenti  ²⁷, George Papatheodoridis  ²⁸, Giovanni Musso  ²⁹, Yu-Jun Wong  ^{30   31}, Mohamed El-Kassas  ³², Nahum Méndez-Sánchez  ³³, Silvia Sookoian  ³⁴, Michael Pavlides  ³⁵, Ajay Duseja  ³⁶, Adriaan G Holleboom  ³⁷, Junping Shi  ³⁸, Wah-Kheong Chan  ³⁹, Yasser Fouad  ⁴⁰, Junwei Yang  ⁴¹, Sombat Treeprasertsuk  ⁴², Helena Cortez-Pinto  ⁴³, Masahide Hamaguchi  ⁴⁴, Manuel Romero-Gomez  ⁴⁵, Mamun Al Mahtab  ⁴⁶, Ponsiano Ocama  ⁴⁷, Atsushi Nakajima  ⁴⁸, Chunsun Dai  ⁴¹, Mohammed Eslam  ⁴⁹, Lai Wei  ⁵⁰, Jacob George  ⁴⁹, Ming-Hua Zheng  ^{51   52} （Affiliations ¹ Department of Nephrology, Jiangnan University Medical Center, Wuxi, China. ² Affiliated Wuxi Clinical College of Nantong University, Wuxi, China. ³ Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy. ⁴ Southampton National Institute for Health and Care Research Biomedical Research Centre, University Hospital Southampton, and Southampton General Hospital, University of Southampton, Southampton, UK. ⁵ Department of Renal Medicine, University College London, London, UK. ⁶ Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China. ⁷ Center for Fatty Liver, Department of Gastroenterology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁸ Department of Internal Medicine I, Gastroenterology, Endocrinology & Metabolism, Medical University Innsbruck, Innsbruck, Austria. ⁹ Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁰ Division of Nephrology, Department of Medicine, Würzburg University Clinic, Würzburg, Germany. ¹¹ Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China. ¹² Section of Gastroenterology, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA. ¹³ Division of Nephrology, Department of Medicine (M.K.), Koc University School of Medicine, Istanbul, Turkey. ¹⁴ Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University Medical Center, Palo Alto, CA, USA. ¹⁵ Department of Epidemiology and Population Health, Stanford University Medical Center, Palo Alto, CA, USA. ¹⁶ Section of Nephrology and Institute of Clinical and Translational Research, Baylor College of Medicine, and Michael E. DeBakey VA Medical Center, Houston, TX, USA. ¹⁷ Department of Gastroenterology, School of Medicine, Marmara University, Istanbul, Turkey. ¹⁸ Department of Gastroenterology, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey. ¹⁹ Department of Cardiology, Shunde Hospital, Southern Medical University, Foshan, China. ²⁰ Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia. ²¹ Department of Woman, Child and of General and Specialized Surgery, Università della Campania "Luigi Vanvitelli", Napoli, Italy. ²² HIFIH Laboratory, UPRES EA3859, Angers University, Angers, France. ²³ Hepato-Gastroenterology and Digestive Oncology Department, Angers University Hospital, Angers, France. ²⁴ Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou, China. ²⁵ Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Republic of Korea. ²⁶ Cholestatic Liver Diseases Center, Department of Gastroenterology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China. ²⁷ Department of Pathophysiology and Transplantation, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Università degli Studi di Milano, Milan, Italy. ²⁸ Department of Gastroenterology, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens, Athens, Greece. ²⁹ Emergency and Intensive Care Medicine, HUMANITAS Gradenigo Hospital. ³⁰ Department of Gastroenterology & Hepatology, Changi General Hospital, Singhealth, Singapore, Singapore. ³¹ Duke-NUS Medical School, Singapore, Singapore. ³² Department of Endemic Medicine, Faculty of Medicine, Helwan University, Cairo, Egypt. ³³ Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City, Mexico. ³⁴ Clinical and Molecular Hepatology, Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS), Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. ³⁵ Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK. ³⁶ Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. ³⁷ Department of Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands. ³⁸ Department of Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China. ³⁹ Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia. ⁴⁰ Department of Gastroenterology, Hepatology and Endemic Medicine, Faculty of Medicine, Minia University, Minya, Egypt. ⁴¹ Center for Kidney Disease, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, China. ⁴² Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. ⁴³ Clínica Universitária de Gastrenterologia, Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal. ⁴⁴ Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. ⁴⁵ UCM Digestive Diseases, University Hospital Virgen del Rocio, Institute of Biomedicine of Seville (CSIC/HUVR/US), Ciberehd, University of Seville, Sevilla, Spain. ⁴⁶ Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. ⁴⁷ Department of Medicine, Makerere University of College of Health Sciences, Kampala, Uganda. ⁴⁸ Department of Gastroenterology and Hepatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan. ⁴⁹ Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital and University of Sydney, Sydney, NSW, Australia. ⁵⁰ Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China. ⁵¹ MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. ⁵² Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.）

出处： Hepatobiliary surgery and nutrition 2023

关键词： Metabolic dysfunction-associated fatty liver disease (MAFLD);chronic kidney disease (CKD);consensus;non-alcoholic fatty liver disease (NAFLD).

摘要： Background: With the rising global prevalence of fatty liver disease related to metabolic dysfunction, the association of this common liver condition ...

作者： Guizhi Zhang  ¹, Mengsi Zhan  ¹, Changchang Zhang  ¹, Zhiqiang Wang  ¹, Huxiao Sun  ¹, Yuchen Tao  ², Qiusheng Shi  ², Meijuan He  ³, Han Wang  ³, João Rodrigues  ⁴, Mingwu Shen  ¹, Xiangyang Shi  ^{1   4} （Affiliations ¹ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China. ² Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁴ CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus Universitário da Penteada, Funchal, 9020-105, Portugal.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023

关键词： chemoimmunotherapy;dendrimer nanogels;immunogenic cell death;redox-responsiveness;ultrasound-targeted microbubble destruction.

摘要： Developing a multifunctional nanoplatform to achieve efficient theranostics of tumors through multi-pronged strategies remains to be challenging. Here ...

作者： Ahmed Mohyeldin  ^{1   2}, Maximiliano Alberto Nunez  ¹, Yuanzhi Xu  ^{1   3}, Juan C Fernandez-Miranda  ¹ （Affiliations ¹ Department of Neurosurgery, Stanford University Medical Center, Stanford, California. ² Department of Neurosurgery, University of California, Irvine, Orange, California. ³ Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Neurosurgical focus: Video 2023

关键词： Cushing’s disease;biochemical remission;cavernous sinus invasion;medial wall of the cavernous sinus;pituitary adenoma.

摘要： Emerging evidence from multiple highly specialized groups continues to support a role for resection of the medial wall of the cavernous sinus when it ...