作者： Kuokuo Li  ^{1   2   3}, Yuge Chen  ^{1   2   3}, Yuying Sheng  ^{1   2   3}, Dongdong Tang  ^{1   2   3}, Yunxia Cao  ^{1   2   3}, Xiaojin He  ⁴ （Affiliations ¹ Department of Obstetrics and Gynecology, Reproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. ² NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui, China. ³ Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, Hefei, Anhui, China. ⁴ Department of Obstetrics and Gynecology, Reproductive Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Human reproduction update 2025

关键词： cis-acting element;infertility;mRNA splicing;non-canonical splicing variant;splicing variant prediction and validation;therapy;trans-acting factor.

摘要： Background: mRNA splicing is a fundamental process in the reproductive system, playing a pivotal role in reproductive development and endocrine functi ...

作者： Pengtao Shi  ¹, Shen Rui  ², Qingyou Meng  ^{3   4} （Affiliations ¹ Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China. ² School of Pharmacy, China Medical University, Shenyang, 110122, China. 2024110394@cmu.edu.cn. ³ Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, 214122, China. mengqy@163.com. ⁴ Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. mengqy@163.com.）

出处： BMC cardiovascular disorders 2025

关键词： 28-Day Mortality;Cardiac Surgery;Creatinine to Albumin Ratio;MIMIC-IV Database.

摘要： Background: Creatinine-to-albumin ratio (CAR) has been recognized as a predictive indicator in the postoperative setting. However, its relationship wi ...

作者： Yue Wu ^{#  1}, Siyuan Wu ^{#  1}, Yinghai Yu ^{#  2   3}, Xiaojun Hu  ², Ting Zhao  ¹, Yan Jiang  ¹, Bilian Ke  ¹ （Affiliations ¹ Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai, China. ³ School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.）

出处： Frontiers in cell and developmental biology 2025

关键词： blinking pattern;children;deep learning system;orthokeratology;tear film.

摘要： Purpose: Using deep learning model to observe the blinking characteristics and evaluate the changes and their correlation with tear film characteristi ...

作者： Nana Wang  ^{1   2}, Yan Hou  ³, Lili Lin  ², Shihui Xu  ³, Kyubae Lee  ⁴, Yingjun Yang  ⁵, Yazhou Chen  ⁶, Yachun Li  ², Xiuhui Wang  ⁷, Yongtao Wang  ², Tao Chen  ¹ （Affiliations ¹ Department of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. ² Department of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China. ³ School of Medicine, Shanghai University, Shanghai, 200444, China. ⁴ Department of Biomedical Materials, Konyang University, Daejeon, 35365, Republic of Korea. ⁵ Materials Institute of Atomic and Molecular Science, Shaanxi University of Science and Technology, Xi'an, 710021, China. ⁶ Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450003, China. ⁷ Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： advanced microarrays;force‐sensing mechanotransduction;heterogeneous focal adhesion;mechanical remodeling;nuclear configuration.

摘要： Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin-related force remodeling and play an important role in nuclear conf ...

作者： Hongyuan Song ^{#  1   2   3   4}, Qing Li ^{#  5   6}, Xiao Gui ^{#  5   7}, Ziyu Fang ^{#  8}, Wen Zhou ^{#  5}, Mengzhu Wang  ⁵, Yuxin Jiang  ^{9   10}, Ajun Geng  ^{11   12}, Xi Shen  ¹³, Yongxuan Liu  ⁵, Haorui Zhang  ⁵, Zheng Nie  ⁵, Lin Zhang  ⁵, Huimin Zhu  ⁵, Feng Zhang  ¹⁴, Xuri Li  ¹⁴, Fanyan Luo  ¹⁵, Hongjian Zhang  ^{16   17}, Wei Shen  ¹⁸, Xiaodong Sun  ^{19   20   21} （Affiliations ¹ Department of Ophthalmology, Shanghai Changhai Hospital, Shanghai, China. hongyuansong@hotmail.com. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hongyuansong@hotmail.com. ³ National Clinical Research Center for Ophthalmic Diseases, Shanghai, China. hongyuansong@hotmail.com. ⁴ Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai, China. hongyuansong@hotmail.com. ⁵ Department of Ophthalmology, Shanghai Changhai Hospital, Shanghai, China. ⁶ The Affiliated Eye Hospital of Nanjing Medical University, Nanjing, China. ⁷ Department of Ophthalmology, Yuanwang Hospital, Wuxi, China. ⁸ Department of Urology, Shanghai Changhai Hospital, Shanghai, China. ⁹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁰ Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. ¹¹ Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, China. ¹² New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. ¹³ Department of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁴ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. ¹⁵ Department of Cardiac Surgery, Xiangya Hospital, Central South University, Changsha, China. drlfy@csu.edu.cn. ¹⁶ Oriental Pan-Vascular Devices Innovation College, University of Shanghai for Science and Technology, Shanghai, China. hongjian_zhang@usst.edu.cn. ¹⁷ Shidong Hospital Affiliated to University of Shanghai for Science and Technology, 999 Shiguang Road, Shanghai, China. hongjian_zhang@usst.edu.cn. ¹⁸ Department of Ophthalmology, Shanghai Changhai Hospital, Shanghai, China. shenwei@smmu.edu.cn. ¹⁹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xdsun@sjtu.edu.cn. ²⁰ National Clinical Research Center for Ophthalmic Diseases, Shanghai, China. xdsun@sjtu.edu.cn. ²¹ Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. xdsun@sjtu.edu.cn.）

出处： Nature communications 2025

摘要： Pathological retinal neovascularization (RNV) is one of the leading causes of blindness worldwide; however, its underlying mechanism remains unclear. ...

作者： Zhi-Chao Xi ^{#  1   2}, Han-Gui Ren ^{#  1   2}, Lin Ai  ³, Yuan Wang  ³, Meng-Fan Liu  ^{1   2}, Yu-Fei Qiu  ³, Ji-Ling Feng  ⁴, Wang Fu  ³, Qian-Qian Bi  ³, Feng Wang  ⁵, Hong-Xi Xu  ^{6   7} （Affiliations ¹ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. ² Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China. ³ Department of Neurology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. ⁴ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ⁵ Department of Neurology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. wangfengshutcm@163.com. ⁶ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. xuhongxi88@gmail.com. ⁷ Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China. xuhongxi88@gmail.com.）

出处： Acta pharmacologica Sinica 2025

作者： Qi Zhang  ^{1   2}, Xuliren Wang  ^{1   2}, Zhibo Shao  ^{1   2}, Yi Zhang  ^{1   2}, Liyi Zhang  ^{1   2}, Ming Chen  ^{1   2}, Xujie Zhou  ^{1   2}, Han Zhu  ¹, Yue Zhou  ^{1   2}, Xinya Lu  ^{1   2}, Pei Li  ^{1   2}, Weiru Chi  ^{1   2}, Lun Li  ^{1   2   3}, Zhi-Ming Shao  ^{1   2}, Shenglin Huang  ⁴, Jingyan Xue  ^{1   2}, Yayun Chi  ^{1   2   5}, Jiong Wu  ^{1   2   6}, Bingqiu Xiu  ^{1   2} （Affiliations ¹ Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. ² Department of Oncology, Fudan University Shanghai Medical College, Shanghai, 200032, China. ³ Department of General Surgery, The Second Xiangya Hospital, Central South University, Hunan, 410011, China. ⁴ Fudan University Shanghai Cancer Center, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. ⁵ Pathology Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. ⁶ Collaborative Innovation Center for Cancer Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： ATR inhibitors;DNA replication licensing;HER2‐positive breast cancers;LINC01235;chromosomal instabilities.

摘要： Despite the development of HER2-targeting drugs such as trastuzumab and T-DXd, treatment resistance is a substantial challenge, often leading to relap ...

作者： Jie Xu  ¹, Haixin Wang  ², Min Lu  ³, Hai Bi  ⁴, Deng Li  ⁴, Zixuan Xue  ⁵, Qi Zhang  ⁶ （Affiliations ¹ School of Information Technology and Management, University of International Business and Economics, Beijing 100029, China. ² Cadre Medical Department, The 1st medical Center, Chinese PLA General Hospital, Beijing 100853, China. ³ Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China. ⁴ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ⁵ Department of Urology, Peking University Third Hospital, Beijing 100191, China. ⁶ School of Information Technology and Management, University of International Business and Economics, Beijing 100029, China. Electronic address: zhangqi@uibe.edu.cn.）

出处： Computer methods and programs in biomedicine 2025

关键词： Deep learning;Medical information processing;Tumor segmentation;Uncertainty estimation.

摘要： Background and objective: Although deep learning-based intelligent diagnosis of bladder cancer has achieved excellent performance, the reliability of ...

作者： Jing Li  ¹, Shizhe Liu  ², Sunghwan Kim  ¹, Jacob Goell  ¹, Zachary Allen Drum  ³, John Patrick Flores  ³, Alex J Ma  ¹, Barun Mahata  ¹, Mario Escobar  ¹, Alex Raterink  ⁴, Jeong Hyun Ahn  ⁵, Erik R Terán  ², Rosa Selenia Guerra-Resendez  ⁴, Yuhao Zhou  ¹, Bo Yu  ⁶, Michael R Diehl  ^{1   7}, Gang Greg Wang  ^{5   8}, Anna-Karin Gustavsson  ^{2   4   7}, Douglas H Phanstiel  ³, Isaac B Hilton  ^{1   2   4} （Affiliations ¹ Department of Bioengineering, Rice University, Houston, TX, 77030, United States. ² Department of BioSciences, Rice University, Houston, TX, 77030, United States. ³ Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States. ⁴ Systems, Synthetic, and Physical Biology Graduate Program, Rice University, Houston, TX, 77030, United States. ⁵ Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States. ⁶ Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁷ Department of Chemistry, Rice University, Houston, TX, 77030, United States. ⁸ Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC, 27710, United States.）

出处： Nucleic acids research 2025

摘要： Protein intrinsically disordered regions (IDRs) are critical gene-regulatory components and aberrant fusions between IDRs and DNA-binding/chromatin-as ...

作者： Shu-Juan Ni  ^{1   2}, Xin Wang  ^{1   2}, Lin Yuan  ³, Hui Dong  ⁴, Hui Sun  ^{1   2}, Cong Tan  ^{1   2}, Xu Cai  ^{1   2}, Wenhua Jiang  ^{1   2}, Weiqi Sheng  ^{1   2}, Midie Xu  ^{5   2}, Dan Huang  ^{5   2} （Affiliations ¹ Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China. ² Department of Oncology, Fudan University Shanghai Medical College, Shanghai, People's Republic of China. ³ Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China danhuang@shca.org.cn xumd27202003@sina.com yuanlin_li@126.com huidong@smmu.edu.cn. ⁴ Department of Pathology, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, People's Republic of China danhuang@shca.org.cn xumd27202003@sina.com yuanlin_li@126.com huidong@smmu.edu.cn. ⁵ Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China danhuang@shca.org.cn xumd27202003@sina.com yuanlin_li@126.com huidong@smmu.edu.cn.）

出处： Journal of clinical pathology 2025

关键词： Antibodies;Gallbladder Neoplasms;IMMUNOHISTOCHEMISTRY;Monoclonal.

摘要： Aims: Gallbladder carcinoma (GBC) is frequently diagnosed and treated in advanced stages and has a poor prognosis. Recent studies have identified clau ...