作者： Zhiqiang Wang  ¹, Yunqi Guo  ¹, Gaoming Li  ¹, Meijuan He  ², Yanying Li  ¹, Zhiyun Liu  ¹, Han Wang  ², Mingwu Shen  ¹, Xiangyang Shi  ¹ （Affiliations ¹ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China. ² Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.）

出处： ACS applied materials & interfaces 2025

关键词： antibody delivery;combined tumor therapy;dendrimer;immune activation;metal-phenolic network.

摘要： To simplify the composition and improve the efficacy of metal-phenolic network (MPN)-based nanomedicine, herein, we designed an MPN platform to delive ...

作者： Ying Cao  ¹, Ruolan Qian  ¹, Ruilian Yao  ², Quan Zheng  ³, Chen Yang  ¹, Xupeng Yang  ⁴, Shuyi Ji  ⁴, Linmen Zhang  ¹, Shujie Zhan  ¹, Yiping Wang  ⁵, Tianshi Wang  ⁶, Hui Wang  ¹, Chun-Ming Wong  ⁷, Shengxian Yuan  ⁸, Christopher Heeschen  ³, Qiang Gao  ⁴, René Bernards  ⁹, Wenxin Qin  ¹⁰, Cun Wang  ¹¹ （Affiliations ¹ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. ³ Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Liver Surgery and Transplantation, Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China. ⁵ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Nephrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ State Key Laboratory for Liver Research and Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China. ⁸ The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China. ⁹ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: r.bernards@nki.nl. ¹⁰ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: wxqin@sjtu.edu.cn. ¹¹ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: cwang@shsci.org.）

出处： Developmental cell 2025

关键词： DYRK1A;IACS-010759;TGF-β signaling;hepatocellular carcinoma;oxidative phosphorylation.

摘要： Intervening in mitochondrial oxidative phosphorylation (OXPHOS) has emerged as a potential therapeutic strategy for certain types of cancers. Employin ...

作者： Ying Yuan  ^{1   2   3}, Fang Li  ⁴, Weijung Ten  ^{1   5}, Chengcheng Jin  ¹, Yue Wu  ⁶, Yuying Liu  ⁶, Bilian Ke  ⁷ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² National Clinical Research Center for Eye Diseases, Shanghai, China. ³ Shanghai Key Laboratory of Fundus Disease, Shanghai, China. ⁴ Department of Ultrasonography, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China. ⁶ Department of Ophthalmology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200001, China. ⁷ Department of Ophthalmology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200001, China. kebilian@126.com.）

出处： Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2025

关键词： Choroidal thickness;Choroidal vascularity;High myopia;Peripapillary retinal nerve fiber layer;Scleral elastic modulus;Shear wave elastography.

摘要： Purpose: To evaluate the posterior scleral stiffness of different regions in high myopic eyes and to explore its associations with macular choroidal a ...

作者： Jie Yang  ^{1   2   3}, Xin Zeng  ^{1   2   3}, Junxia Pei  ^{1   2   4}, Zhou Su  ^{1   2   3}, Qi Liu  ^{1   2   4}, Yamei Zhang  ⁵, Yixi Yang  ^{1   2   4}, Rui Li  ^{1   2   4}, Fei Zhou  ⁶, Yu Deng  ^{7   8   9} （Affiliations ¹ Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu, 610106, China. ² Institute of Cancer Biology and Drug Discovery, Chengdu University, Chengdu, 610106, China. ³ School of Pharmacy, Chengdu University, Chengdu, 610106, China. ⁴ School of Food and Biological Engineering, Chengdu University, Chengdu, 610106, China. ⁵ Key Laboratory of Clinical Genetics, Affiliated Hospital of Chengdu University, Chengdu, 610106, China. ⁶ Department of Oncology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. zhoufei.2013@hotmail.com. ⁷ Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, Chengdu, 610106, China. dengyu@cdu.edu.cn. ⁸ Institute of Cancer Biology and Drug Discovery, Chengdu University, Chengdu, 610106, China. dengyu@cdu.edu.cn. ⁹ School of Basic Medical Sciences, Chengdu University, Chengdu, 610106, China. dengyu@cdu.edu.cn.）

出处： Medical oncology (Northwood, London, England) 2025

关键词： FANCD2;Melanoma;Protocatechuic aldehyde;Synergy;Temozolomide.

摘要： Temozolomide (TMZ)-based chemotherapy is a primary regimen for melanoma patients who have failed targeted therapy or immunotherapy. However, the low r ...

作者： Xin Luo  ¹, Kan Chen  ², Jie Zhang  ², Zhilu Yao  ³, Chuanyong Guo  ², Ying Qu  ¹, Lungen Lu  ¹, Yuqing Mao  ¹ （Affiliations ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. ³ Department of Gastroenterology, Jing'an District Zhabei Central Hospital, Shanghai, China.）

出处： FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025

关键词： exosomes;ferroptosis;ghrelin;liver fibrosis;lncMALAT1.

摘要： Ghrelin reduced the profibrotic effect of IHC-Exo in liver fibrosis by regulating lncMALAT1/GPX4 pathway mediated HSCs ferroptosis. Triggering HSCs fe ...

作者： Yihan Wang  ¹, Shunxiang Li  ¹, Tong Li  ², Jiao Wu  ¹, Yida Huang  ¹, Wanshan Liu  ¹, Chunmeng Ding  ¹, Lin Huang  ¹, Xiaoyu Xu  ¹, Yuning Wang  ¹, Sai Gu  ³, Kun Liu  ⁴, Kun Qian  ¹, Xiaodong Sun  ⁴ （Affiliations ¹ State Key Laboratory for Oncogenes and Related Genes, School of Biomedical Engineering, Institute of Medical Robotics and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China. ² Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai Gene Therapy Center, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China. ³ Department of Chemical Engineering, The University of Warwick, Coventry, CV4 8UW, UK. ⁴ Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai Gene Therapy Center, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200040, P. R. China.）

出处： Small (Weinheim an der Bergstrasse, Germany) 2025

关键词： diabetic retinopathy;dual body fluids;metabolic fingerprint;vitreous liquid.

摘要： Diabetic retinopathy (DR) is a microvascular complication of diabetes, affecting 34.6% of diabetes patients worldwide. Early detection and timely trea ...

作者： Chaoxiang Du  ^{1   2}, Yunfan Hu  ¹, Xinyu Yang  ¹, Zhe Zhang  ³, Jianmin Gu  ^{1   4}, Tao Zhang  ², Renfeng Wang  ², Shaoyuan Zhang  ¹, Lijie Tan  ¹, Guiping Yu  ³ （Affiliations ¹ Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, 200032 Shanghai, China. ² Department of Thoracic Surgery, Zhongshan Hospital (Xiamen), Fudan University, 361006 Xiamen, Fujian, China. ³ Department of Cardiothoracic Surgery, The Affiliated Jiangyin Hospital of Nantong University, 214400 Jiangyin, Jiangsu, China. ⁴ Department of Vascular Surgery, General Surgery Clinical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.）

出处： Frontiers in bioscience (Landmark edition) 2025

关键词： NF-κB;SENP5;SLC1A3;oesophageal squamous cell carcinoma.

摘要： Background: This study investigates the role of small ubiquitin-like modifier (SUMO)-specific peptidase 5 (SENP5), a key regulator of SUMOylation, in ...

作者： Wei Gong ^{#  1   2}, Bo Zhang ^{#  1}, Dengji Zhou  ³, Saiguang Ling  ³, Jinliuxing Yang  ¹, Jun Chen  ¹, Jingjing Wang  ¹, Xun Xu  ^{1   2}, Xiangui He  ^{4   5}, Wei Gao  ⁶ （Affiliations ¹ Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongii University, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. ³ EVision technology (Beijing) co. LTD., Beijing, China. ⁴ Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongii University, Shanghai, China. xianhezi@163.com. ⁵ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. xianhezi@163.com. ⁶ Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongii University, Shanghai, China. gaowei1108@hotmail.com.）

出处： Eye (London, England) 2025

摘要： Objectives: To identify the role of fundus vascular arcades angle (VAA) in reflecting choroidal thickness (ChT) of highly myopic children and adolesce ...

作者： Xinjuan Zhang  ^{1   2   3   4}, Cunxiu Fan  ^{5   1}, Yanqiu Liu  ⁶, Cunhua Zhao  ⁷, Yuhua Zhao  ⁸, Wu Yin  ⁹, Jianzhong Lin  ¹⁰, Jiaxing Zhang  ¹ （Affiliations ¹ Institute of Brain Disease and Cognition, School of Medicine, Xiamen University, 4221 Xiang'an South Road, Xiamen 361102, China. ² School of Education and Psychology, Minnan Normal University, 36 Xianqianzhi Street, Zhangzhou 363000, China. ³ Institute of Applied Psychology, Minnan Normal University, 36 Xianqianzhi Street, Zhangzhou 363000, China. ⁴ Fujian Province Key Laboratory of Applied Cognition and Personality, Minnan Normal University, 36 Xianqianzhi Street, Zhangzhou 363000, China. ⁵ Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai 201803, P.R. China. ⁶ Physical Education Institute, Jimei University, No. 185 Yinjiang Road, Jimei District, Xiamen 361021, China. ⁷ School of Medicine, Tibet University, No. 1, Norbulingka North Road, Chengguan District, Lhasa, Tibet Autonomous Region 850000, China. ⁸ Institute of High Altitude Medicine, Tibet Autonomous Region People's Hospital, No. 18, Linguo North Road, Chengguan District, Lhasa, Tibet Autonomous Region 850013, China. ⁹ Department of Radiology, Tibet Autonomous Region People's Hospital, No. 18, Linguo North Road, Chengguan District, Lhasa, Tibet Autonomous Region 850013, China. ¹⁰ Department of Radiology, Zhongshan Hospital of Xiamen University, School of Medicine, 201-209 Hubin South Road, Xiamen 361004, China.）

出处： Cerebral cortex (New York, N.Y. : 1991) 2025

关键词： MRI;Tibetans;brain;gender differences;high altitude.

摘要： Gender differences in adaptation to high-altitude environments are evident, but the specific patterns in Tibetan brains remain unclear. We analyzed T1 ...

作者： Xin Han  ¹, Chenjun Lv  ² （Affiliations ¹ Pathology Center, Shanghai General Hospital, 85 Wujin Road, Shanghai, 200080, China. ² Pathology Center, Shanghai General Hospital, 85 Wujin Road, Shanghai, 200080, China. chenjun.lv@outlook.com.）

出处： Discover oncology 2025

关键词： Cell migration;Cell proliferation;JAK/STAT pathway;MiRNA-21;Prostate cancer.

摘要： This research explored the role of microRNA (miRNA)-21 in prostate cancer (PCa) cells, as well as its regulation of the JAK/STAT pathway in PCa cells. ...