作者： Meihua Zhao ¹, Xisheng Yu ², Meizeng Zhao ³, Guoqing Zhang ⁴ （Affiliations ¹ Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai 201803, P.R.China. ² College of Mechanical Engineering, Donghua University, Shanghai 201620, China. ³ Department of Internal Medicine, Xinjiang Uygur Autonomous Region Rehabilitation Hospital, Urumqi, Xinjiang Uygur Autonomous Region 830000, China. ⁴ Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai 201803, P.R.China. Electronic address: 18299081608@163.com.）

出处： Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2026

关键词： epidemiology and clinical diagnosis;lower respiratory tract infections;metagenomic next-generation sequencing;standardized application protocol.

摘要： Objectives: This study aims to assess the impact of metagenomic next-generation sequencing (mNGS) on optimizing diagnostic-therapeutic pathways for lo ...

作者： Xiaohan Zhou  ¹, Shushan Mo  ^{1   2}, Zhenzhen Wang  ², Wei Xu  ³, Xueyi Wang  ^{1   4} （Affiliations ¹ The Tenth Affiliated Hospital, Southern Medical University (Dongguan People's Hospital), Dongguan, China. ² School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou, China. ³ Orthopedics Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ College of Chemistry and Materials Science, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, China.）

出处： Small (Weinheim an der Bergstrasse, Germany) 2026

关键词： artificial cells;artificial organelles;liquid–liquid phase separation;spatiotemporal organization.

摘要： Living cells regulate biochemical reactions through compartmentalization, achieving high efficiency by precisely controlling spatial and temporal fact ...

作者： Yi-Bang Cheng  ¹, De-Wei An  ¹, Dong-Yan Zhang  ^{1   2   3}, Yu-Ling Yu  ^{2   3}, Jesus D Melgarejo  ^{4   5   6}, José Boggia  ⁷, Dries S Martens  ⁸, Tine W Hansen  ^{2   9   10}, Kei Asayama  ^{2   11   12}, Takayoshi Ohkubo  ¹², Katarzyna Stolarz-Skrzypek  ^{2   13}, Qi-Fang Huang  ¹, Sofia Malyutina  ¹⁴, Edoardo Casiglia  ¹⁵, Lars Lind  ¹⁶, Gladys E Maestre  ^{2   4   5   6}, Ji-Guang Wang  ¹, Masahiro Kikuya  ¹², Kalina Kawecka-Jaszcz  ¹³, Eamon Dolan  ¹⁷, Edgardo Sandoya  ¹⁸, Marek Rajzer  ¹³, Tim S Nawrot  ^{3   8}, Krzysztof Narkiewicz  ¹⁹, Wen-Yi Yang  ²⁰, Peter Verhamme  ²¹, Jan Filipovský  ²², Auxiliadora Graciani  ²³, José R Banegas  ²³, Yan Li ^{#  1}, Jan A Staessen ^{#  1   2   24   13}; International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes Investigators （Affiliations ¹ Department of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, National Research Centre for Translational Medicine, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China. (Y.-B.C, D.-W.A., D.-Y.Z., Q.-F.H., J.G.W., Y.L., J.A.S). ² Non-Profit Research Association Alliance for the Promotion of Preventive Medicine, Mechelen, Belgium (D.-Y.Z., Y.-L.Y, T.W.H., K.A., K.S.-S., G.E.M., J.A.S). ³ Research Unit Environment and Health, KU Leuven Department of Public Health and Primary Care, University of Leuven, Belgium. (D.-Y.Z., Y.-L.Y., T.S.N.). ⁴ Institute of Neuroscience, Neuro and Behavioral Health Integrated Service Unit, University of Texas Rio Grande Valley, Harlingen (J.D.M., G.E.M). ⁵ South Texas Alzheimer's Disease Research Center, San Antonio/Harlingen (J.D.M., G.E.M). ⁶ Faculty of Medicine, Laboratory of Neurosciences, University of Zulia, Venezuela (J.D.M., G.E.M). ⁷ Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay (J.R.B.). ⁸ Center for Environmental Sciences, Hasselt University, Diepenbeek, Belgium (D.S.M., T.S.N.). ⁹ The Steno Diabetes Center Copenhagen and Center for Health, Denmark (T.W.H.). ¹⁰ Department of Clinical Medicine, University of Copenhagen, Denmark (T.W.H.). ¹¹ Tohoku Institute for Management of Blood Pressure, Sendai, Japan (K.A.). ¹² Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan (K.A., T.O., M.K.). ¹³ The First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland (K.S.-S., K.K.-J., M.R., J.A.S). ¹⁴ Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk (S.M.). ¹⁵ Department of Medicine, University of Padua, Italy (E.C.). ¹⁶ Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Sweden (L.L.). ¹⁷ School of Medicine, Stroke Service, University College Cork, Ireland (E.D.). ¹⁸ Asociación Española, Montevideo, Uruguay (E.S.). ¹⁹ Hypertension Unit, Department of Hypertension and Diabetology, Medical University of Gdańsk, Poland (K.N.). ²⁰ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. (W.-Y.Y.). ²¹ Center for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium. (P.V.). ²² Department of Internal Medicine II, University Hospital, Charles University Medical School, Pilsen, Czech Republic (J.F.). ²³ Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid/CIBERESP, Spain (A.G., J.R.B). ²⁴ Biomedical Research Group, Faculty of Medicine, University of Leuven, Belgium. (J.A.S).）

出处： Hypertension (Dallas, Tex. : 1979) 2026

关键词： blood pressure;cardiovascular diseases;morbidity;mortality;vascular stiffness.

摘要： Background: The ambulatory arterial stiffness index (AASI) is increasingly used in clinical research and practice. This individual-participant meta-an ...

作者： Qing Chen ¹, Rongpan Wu ², Chen Zhang ¹, Jiaxin Xie ¹, Yi Wang ¹, Xufeng Yu ¹, Wei He ¹, Maoyu Wang ¹, Junjie Zhao ³, Zhensheng Zhang ⁴, Shuxiong Zeng ⁵, Chuanliang Xu ⁶ （Affiliations ¹ Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China. ² Department of Urology, Jinjiang Hospital Jinnan Branch Courts, Jinjiang, China. ³ Department of Urology, Yantai Yuhuangding Hospital, Yantai, China. ⁴ Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China. Electronic address: 13761178177@163.com. ⁵ Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China. Electronic address: zengshuxiong@126.com. ⁶ Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: chuanliang_xu@126.com.）

出处： Urologic oncology 2026

关键词： High risk;Intravesical chemotherapy;Non-muscle-invasive bladder cancer;Recurrent;Tislelizumab.

摘要： Background: Recurrent high-risk non-muscle-invasive bladder cancer (HR-NMIBC) poses significant therapeutic challenges due to frequent recurrences. Ba ...

作者： Genbin Wu^{1 na1};Xinmeng Jin^{1 na1};Jinwei Chen¹;Zhongwei Sun²;Peng Miao¹;Haifeng Zhang¹ & …Yinxian Yu¹ （¹Department of Orthopedic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200240, China;²Department of Orthopedic Surgery, Tongzhou District People’s Hospital of Nantong, Jiangsu Province, Nantong, 226300, China）

出处： Arthroplasty 2026

关键词： Unicompartmental knee arthroplasty;Perioperative varus deformity change;Mechanical alignment

摘要： Background Although favorable survival and good outcomes have been reported with Oxford unicompartmental knee arthroplasty (UKA), the effect of perio ...

作者： Zhao Wang ^{#  1}, Lin Liang ^{#  2}, Hao Xu  ², Yuhui Huang  ², Chen He  ³, Weiran Xu  ⁴, Haojie Zhu  ³ （Affiliations ¹ Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China. ² Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. ⁴ Department of Medical Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.）

出处： Frontiers in artificial intelligence 2026

关键词： artificial intelligence;cardio-oncology;large language models;patient education;prompt engineering.

摘要： Background: The integration of large language models (LLMs) into cardio-oncology patient education holds promise for addressing the critical gap in ac ...

作者： Shisong Chen ^{# 1}, Hanyu Shen ^{# 2}, Huiying Zhang ^{# 3}, Qi Wang ³, Yue Ding ³, Xinxin Pu ³, Chao Yang ³, Ruxi Pang ⁴, Ze Yang ⁵ （Affiliations ¹ Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China. ² Department of Laboratory Medicine, Affiliated Huishan Hospital of Xinglin College, Nantong University, Wuxi Huishan District People's Hospital, Wuxi, Jiangsu Province, 214000, China. ³ Department of Burn and Plastic Surgery, Naval Medical Center of PLA, Shanghai, 200052, China. ⁴ Department of Gastroenterology, Shanghai Institute of Pancreatic Diseases, Changhai Hospital, Shanghai, 200433, China. ⁵ Department of Burn and Plastic Surgery, Naval Medical Center of PLA, Shanghai, 200052, China. yangzeyyr@163.com.）

出处： Cellular and molecular life sciences : CMLS 2026

关键词： EMT;Palmitoylation;Ubiquitination;ZDHHC4;ZEB-2.

摘要： ZDHHC4, a palmitoyl transferase belonging to the DHHC family, is crucial in cells by catalyzing palmitoylation of proteins, thereby regulating their f ...

作者： Ziye Wang MD¹;Changyu Chen MD, PhD¹;Yijin Wu MD¹;Yuki Nagata PhD^2,3;Toshihiro Tanaka MD, PhD^2,3;Shiqi Xie MD, PhD^1,4;Hongshuang Lu MD, PhD¹;Yining Wang MD¹;Jianping Xiong MD, PhD¹;Liwen Zhang MD¹;Koju Kamoi MD, PhD¹;Kyoko Ohno-Matsui MD, PhD¹CA1 （¹Department of Ophthalmology and Visual Science, Institute of Science Tokyo, Tokyo, Japan;²Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan;³Bioresource Research Support Center, Institute of Science Tokyo, Tokyo, Japan;⁴Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China）

出处： Ophthalmology Science 2026

关键词： Posterior staphyloma;Pathologic myopia;COL4A5;Collagen genes;Basement membrane

摘要： Purpose To identify genetic variants in posterior staphylomas in eyes with pathologic myopia using whole exome sequencing and to determine possible mo ...

作者： Tianhui Hou ^{# 1 2}, Huaze Ding ^{# 2}, Guofang Huang ^{# 1 2}, Tong Meng ³, Dianwen Song ^{4 5} （Affiliations ¹ University of Shanghai for Science and Technology, Shanghai, 200093, China. ² Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. mengtong@medmail.com.cn. ⁴ University of Shanghai for Science and Technology, Shanghai, 200093, China. osongdianwen@126.com. ⁵ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. osongdianwen@126.com.）

出处： Cellular oncology (Dordrecht, Netherlands) 2026

摘要： The nervous system is increasingly recognized as a key regulator of the tumor microenvironment, engaging in bidirectional crosstalk with cancer cells ...

作者： Chunrong Ren ¹, Ruxi Deng ², Jiameng Ding ³, Wuyang Wei ², Hai Wang ², Ying Liu ², Li Ding ⁴, Meiqi Chang ⁵, Yu Chen ⁶, Yang Zhou ² （Affiliations ¹ Department of Gastroenterology, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, P. R. China. ² Department of Ultrasound, Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, Sichuan, P. R. China. ³ Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China. ⁴ Department of Orthopaedics, National Clinical Research Center of Interventional Medicine, Shanghai Tenth People's Hospital, Tongji University Cancer Center, Tongji University School of Medicine, Tongji University, Shanghai, P. R. China. ⁵ Science and Technology Innovation Center, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China. ⁶ Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, P. R. China.）

出处： Small (Weinheim an der Bergstrasse, Germany) 2026

关键词： bandgap modulation;enzyme‐mimicking activities, ferroptosis;oxygen defect;sonocatalytic therapy.

摘要： Hepatocellular carcinoma, a malignant tumor with high incidence and mortality rates, urgently requires the development of novel therapeutic strategies ...