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作者: Yiting Gui1,2,3;Yawen Zhang1,2,3;Qi Zhang1;Xudong Chen1;Feng Wang1,2;Fang Wu4;Yonghao Gui2CA1;Qiang Li1CA21Translational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect Prevention and Control, NHC Key Laboratory of Neonatal Diseases, Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China;2Cardiovascular Center, NHC Key Laboratory of Neonatal Diseases, Fudan University, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China;3These authors contributed equally to this work.;4Department of Neonatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China)

出处: Cells & Development 2022

关键词: Cis-regulatory regions;Promoter;Fugu;ECR;TNNI1 (troponin I1);Zebrafish

摘要: Troponin I type 1b (Tnni1b) is thought to be a novel isoform that is expressed only in the zebrafish heart. Knocking down of tnni1b can lead to cardia ...

作者: Xiaomin Xu1;Zongshan Li2;Huirong Zuo3;Huimin Chen2;Yaxing Gui1,2CA11Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China;2Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;3Department of Rehabilitation Medicine, Haining Kanghua Hospital, Jiaxing, Zhejiang 314419, China)

出处: Neuroscience Letters 2022

关键词: Exosomes;Cholesterol;Lipid raft;Parkinson’s disease

摘要: Parkinson’s disease (PD) is associated with abnormal metabolism of brain cholesterol, and the metabolites of neuronal cholesterol may also affect neur ...

作者: Chencheng Yao;Dong Hou;Zhiyong Ji;Dongmei Pang;Peng Li;Ruhui Tian;Yuxiang Zhang;Ningjing Ou;Haowei Bai;Erlei Zhi;Yuhua Huang;Yingying Qin;Jingpeng Zhao;Chenchen Wang;Zhi Zhou;Ting Guo;Zheng Li (Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Jimo Hospital of Traditional Chinese Medicine Affiliated to Shandong University of Traditional Chinese Medicine, Qingdao, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Shanghai Advanced Research Institute, Stem Cell and Reproductive Biology Laboratory, Chinese Academy of Sciences, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China Zhi Zhou, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Ting Guo, Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250012, China. Zheng Li, Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan, China Zhi Zhou, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Ting Guo, Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250012, China. Zheng Li, Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Zhi Zhou, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Ting Guo, Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250012, China. Zheng Li, Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.)

出处: Clinical Genetics 2022

关键词: gene variants;meiosis;NOA;POI;SPATA22

摘要: The genetic causes of idiopathic premature ovarian insufficiency (POI) and nonobstructive azoospermia (NOA) remain unclear. We performed whole-exome s ...

作者: Kailei Shi MD1,2,3;Ren Anmin MD1,3;Junfeng Cai MD4,3;Yiding Qi MD1;Wanlin Han MD1;Mingxuan Li MD1;Guannan Zhang MD5;Shuyi Zhang MD1;Lei Fu MD2;Wenzheng Han MD1;Shaofeng Guan MD1;Jun Li MD6;Lin Qi MD6;Lei Lin MD6;Xinkai Qu MD1CA1;Maoqing Ye MD, PhD1,2CA21Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China;2Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China;3Kailei Shi, Ren Anmin, and Junfeng Cai contributed equally.;4Department of Cardiovascular Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China;5Department of Immunology, Key Laboratory of Immune Microenvironment and Disease, Nanjing Medical University, Nanjing, Jiangsu, China;6Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Journal of Cardiology 2022

关键词: Ascending aortic perivascular adipose tissue;Aortic valve disease;Transcriptome;Inflammation

摘要: Background Ascending aortic perivascular adipose tissue (AA-PVAT) mainly comprises brown adipose tissue (BAT), originates from neural crest cells tha ...

作者: Yuanzheng Zheng;Saihua Huang;Jialing Zhang;Jia Hou;Fang Wu;Wenji Wang;Xiao Han;Yonghao Gui (Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Fudan University, Shanghai, China Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Department of Clinical Immunology, Children's Hospital of Fudan University, Shanghai, China Department of Neonatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Fudan University, Shanghai, China Xiao Han and Yonghao Gui, National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, 399 Wanyuan Road, Minhang, Shanghai, 201102, China. Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Xiao Han and Yonghao Gui, National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, 399 Wanyuan Road, Minhang, Shanghai, 201102, China.)

出处: Cell Proliferation 2022

摘要: Objectives Melatonin has been reported to be an appropriate candidate for mitigating various cardiovascular injuries, owing to its versatility. This s ...

作者: Yaying Sun #  1, Zhiwen Luo #  1, Yisheng Chen #  1, Jinrong Lin  1, Yuhan Zhang  1, Beijie Qi  1, Jiwu Chen  2 (Affiliations 1 Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China. 2 Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. jeevechen@163.com.)

出处: Biomaterials research 2022

关键词: Adhesive capsulitis;Circulating exosomes;Liposomes;Rotator cuff tear;miRNAs.

摘要: Background: Adhesive capsulitis is a common shoulder disorder inducing joint capsule fibrosis and pain. When combined with rotator cuff tear (RCT), tr ...

作者: C R Wang  1, M Kang  2, J Xu  1, Y Lyu  1, Y F Jiang  1, M X Sun  1, D Q Zuo  1, J K Shen  1, X J Ma  1, W Sun  1, Y Q Hua  2, Zhengdong Cai  1 (Affiliations 1 Department of Bone Tumor, Shanghai General Hospital, Shanghai 200080, China. 2 Department of Bone Tumor, Shanghai General Hospital, Shanghai 200080, China Shanghai Cell Therapy Clinical Transformation Engineering Technology Research Center, Shanghai 200080, China.)

出处: Zhonghua yi xue za zhi 2022

摘要: Objective: To explore the safety and efficacy of tumor-infiltrating lymphocytes (TILs) extracted from tumor tissue in patients with pulmonary metastas ...

作者: Tianyu Qin #  1   2, Junpeng Fan #  1   2, Funian Lu  1   2, Li Zhang  1   2, Chen Liu  1   2   3, Qiyue Xiong  1   2, Yang Zhao  4, Gang Chen  5   6, Chaoyang Sun  7   8 (Affiliations 1 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Research building of Tongji Hospital, No.2 Jiankang Avenue, Caidian Street, Caidian District, Wuhan, 430030, China. 2 Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. 3 Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai, 200000, China. 4 Department of Plastic Cosmetic and Burn Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 442008, China. 5 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Research building of Tongji Hospital, No.2 Jiankang Avenue, Caidian Street, Caidian District, Wuhan, 430030, China. gumpc@126.com. 6 Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. gumpc@126.com. 7 Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Research building of Tongji Hospital, No.2 Jiankang Avenue, Caidian Street, Caidian District, Wuhan, 430030, China. suncydoctor@gmail.com. 8 Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. suncydoctor@gmail.com.)

出处: Journal of experimental & clinical cancer research : CR 2022

关键词: Genetically engineered mouse models;Ovarian cancer;Patient-derived organoids;Patient-derived xenograft;Personalised medicine;Preclinical models

摘要: Ovarian cancer (OC) is a heterogeneous malignancy with various etiology, histopathology, and biological feature. Despite accumulating understanding of ...

作者: H D Zou  1, L N Lu  1, Y Xu  1, S L Lin  1 (Affiliation 1 Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Division of Ophthalmology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 200040, China.)

出处: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2022

摘要: Due to factors such as medical resources, public awareness, funding for general screening, or optimized screening models, community-based screening is ...

作者: T Li  1, C H Yang  2, H D Zou  1 (Affiliations 1 Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Division of Ophthalmology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 200040, China. 2 The Pediatric Hospital Affiliated to Fudan University, Shanghai 201102, China.)

出处: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2022

摘要: Two adolescents with T1DM participated in the Shanghai Children and Adolescent DM Eye study (SCADE) 2017-2018. The previous T1DM history of the 2 chil ...

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