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作者: Chencheng Yao;Dong Hou;Zhiyong Ji;Dongmei Pang;Peng Li;Ruhui Tian;Yuxiang Zhang;Ningjing Ou;Haowei Bai;Erlei Zhi;Yuhua Huang;Yingying Qin;Jingpeng Zhao;Chenchen Wang;Zhi Zhou;Ting Guo;Zheng Li (Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Jimo Hospital of Traditional Chinese Medicine Affiliated to Shandong University of Traditional Chinese Medicine, Qingdao, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Shanghai Advanced Research Institute, Stem Cell and Reproductive Biology Laboratory, Chinese Academy of Sciences, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China Zhi Zhou, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Ting Guo, Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250012, China. Zheng Li, Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan, China Zhi Zhou, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Ting Guo, Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250012, China. Zheng Li, Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Zhi Zhou, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Ting Guo, Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250012, China. Zheng Li, Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.)

出处: Clinical Genetics 2022

关键词: gene variants;meiosis;NOA;POI;SPATA22

摘要: The genetic causes of idiopathic premature ovarian insufficiency (POI) and nonobstructive azoospermia (NOA) remain unclear. We performed whole-exome s ...

作者: Kailei Shi MD1,2,3;Ren Anmin MD1,3;Junfeng Cai MD4,3;Yiding Qi MD1;Wanlin Han MD1;Mingxuan Li MD1;Guannan Zhang MD5;Shuyi Zhang MD1;Lei Fu MD2;Wenzheng Han MD1;Shaofeng Guan MD1;Jun Li MD6;Lin Qi MD6;Lei Lin MD6;Xinkai Qu MD1CA1;Maoqing Ye MD, PhD1,2CA21Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China;2Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China;3Kailei Shi, Ren Anmin, and Junfeng Cai contributed equally.;4Department of Cardiovascular Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China;5Department of Immunology, Key Laboratory of Immune Microenvironment and Disease, Nanjing Medical University, Nanjing, Jiangsu, China;6Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Journal of Cardiology 2022

关键词: Ascending aortic perivascular adipose tissue;Aortic valve disease;Transcriptome;Inflammation

摘要: Background Ascending aortic perivascular adipose tissue (AA-PVAT) mainly comprises brown adipose tissue (BAT), originates from neural crest cells tha ...

作者: Yuanzheng Zheng;Saihua Huang;Jialing Zhang;Jia Hou;Fang Wu;Wenji Wang;Xiao Han;Yonghao Gui (Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Fudan University, Shanghai, China Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Department of Clinical Immunology, Children's Hospital of Fudan University, Shanghai, China Department of Neonatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Fudan University, Shanghai, China Xiao Han and Yonghao Gui, National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, 399 Wanyuan Road, Minhang, Shanghai, 201102, China. Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Xiao Han and Yonghao Gui, National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, 399 Wanyuan Road, Minhang, Shanghai, 201102, China.)

出处: Cell Proliferation 2022

摘要: Objectives Melatonin has been reported to be an appropriate candidate for mitigating various cardiovascular injuries, owing to its versatility. This s ...

作者: Yafang Wang  1, Yang Liu  1, Shu Liu  1, Xiaomeng Li  1, Xinxin Liu  1   2, Ming Jiao  3, Yuqin Yang  3, Xueting Luo  1   2, Fenghua Wang  1   2   4   5   6, Xiaoling Wan  1   2, Xiaodong Sun  1   2   4   5   6 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, China200080. 2 Shanghai Key Laboratory of Ocular Fundus Diseases, 100 Haining Road, Shanghai, China200080. 3 Laboratory Animal Center, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Shanghai, China201620. 4 Shanghai Engineering Center for Visual Science and Photomedicine, 100 Haining Road, Shanghai, China200080. 5 National Clinical Research Center for Eye Diseases, 100 Haining Road, Shanghai, China200080. 6 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 100 Haining Road, Shanghai, China200080.)

出处: Disease models & mechanisms 2022 Vol.15 No.3 Pdmm049222

关键词: Cyp4v3;Bietti crystalline dystrophy;Lipid accumulation;Mouse model;Retinal degeneration.

摘要: Bietti crystalline dystrophy (BCD) is an autosomal recessive inherited retinal disease, resulting in blindness in most patients. The etiology and deve ...

作者: Mengmeng Jiang  1, Hai Xie  2, Chaoyang Zhang  3   4, Tianqin Wang  1, Haibin Tian  2, Lixia Lu  2, Jing-Ying Xu  2, Guo-Tong Xu  2, Lin Liu  1, Jingfa Zhang  3   4 (Affiliations 1 Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, China. 4 National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.)

出处: Journal of cellular and molecular medicine 2022

关键词: diabetic retinopathy;fractalkine;microglia;neuroinflammation.

摘要: The concept of diabetic retinopathy (DR) has been extended from microvascular disease to neurovascular disease in which microglia activation plays a r ...

作者: Yumeng Zhang  1, Zhenzhen Zhao  1, Xiaohuan Zhao  1, Hai Xie  2, Chaoyang Zhang  1, Xiaodong Sun  3, Jingfa Zhang  4 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. 2 Tongji Eye Institute, Department of Regenerative Medicine, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: xdsun@sjtu.edu.cn. 4 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: jingfa.zhang@shgh.cn.)

出处: Free radical biology & medicine 2022 Vol.181 P14-28

关键词: HMGB2;Oxidative stress;Photoreceptor;Pyroptosis;Retinal degeneration.

摘要: In the pathogenesis of retinal degenerative diseases, oxidative stress is a key driver leading to photoreceptor death and eventually vision loss. Curr ...

作者: Ying Cao #  1, Ye Tian #  2   3, Heng Zhang  2, Guang-Heng Luo  2, Zhao-Lin Sun  2, Shu-Jie Xia  4 (Affiliations 1 Guizhou University School of Medicine, Guiyang, 550025, Guizhou, China. 2 Department of Urology, Guizhou Provincial People\'s Hospital, Guiyang, 550002, Guizhou, China. 3 Department of Urology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. 4 Department of Urology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. xsj4017@163.com.)

出处: International urology and nephrology 2022 Vol.54 No.3 P499-508

关键词: LUTS;Prostate fibrosis;Sex hormone;TGF-β/Smad signaling pathway.

摘要: Objective: The present study aimed to investigate the effects of an imbalance in the estrogen/androgen ratio on prostate fibrosis. Methods: Different ...

作者: Kaiyuan Liu  1, Yuxin Liao  1, Dong Yang  1, Tianyang Xu  1, Qiuming Gao  1, Wenwei Jiang  1, Lin Fan  1, Pengfei Zan  2, Guodong Li  1 (Affiliations 1 Department of Orthopedics, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, China. 2 Department of Orthopedics, Shanghai First People\'s Hospital, Jiaotong University School of Medicine, Shanghai, China.)

出处: Frontiers in surgery 2022 Vol.9 P692072

关键词: MIS-TKA;clinical effectiveness;gap balance;patellar position;soft tissue balance.

摘要: Background: We hypothesized that subluxating patellar during minimally invasive total knee arthroplasty (MIS-TKA) would affect intraoperative soft tis ...

作者: Kepeng Ou  1, Youjian Li  1, Ling Liu  2, Hua Li  2, Katherine Cox  3, Jiahui Wu  4, Jian Liu  3, Andrew D Dick  5 (Affiliations 1 College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing, China; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. 2 Department of Ophthalmology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China. 3 Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. 4 Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol; Institute of Ophthalmology, University College London, London; National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital, London, UK.)

出处: Neural regeneration research 2022 Vol.17 No.9 P1919-1928

关键词: antioxidants;autophagy enhancers;complement inhibitors;exosomes;neuropeptides;neuroprotective agents;retinal degeneration;senolytics.

摘要: Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons, which ar ...

作者: Shu Yang  1, Bing-Cheng Wu  1, Zhe Cheng  2, Lan Li  3, Yuan-Ping Zhang  4, Hui Zhao  5, Han-Mei Zeng  1, Dong-Fang Qi  1, Zi-Yao Ma  1, Jian-Guo Li  1, Rui Han  1, Fang-Zhou Qu  1, Yan Luo  6, Yi Liu  7, Xiao-Lei Chen  8, Hong-Mei Dai  1 (Affiliations 1 Department of Ophthalmology, The First Hospital of Kunming, Kunming, 650011 Yunnan Province, China. 2 Eye institute of Xiamen University, Xiamen, Fujian, China. 3 Department of Ophthalmology, The Calmette Affiliated Hospital of Kunming Medical University, Kunming, China. 4 Department of Ophthalmology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China. 5 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai 200080, China. 6 Department of Pediatrics, The First Hospital of Kunming, Kunming, 650011 Yunnan Province, China. 7 Department of Otorhinolaryngology, The First Hospital of Kunming, Kunming, 650011 Yunnan Province, China. 8 Department of Endocrinology, The First Hospital of Kunming, Kunming, 650011 Yunnan Province, China.)

出处: Disease markers 2022 Vol.2022 P7550090

摘要: Objective: The aims of our experiment were to compare the microorganisms in meibomian gland secretions from patients with internal hordeolum before an ...

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