作者： Chengyu Hu  ¹, Chengda Ren  ², Yan Wu  ¹, Ruoyi Lin  ¹, Tianyi Shen  ¹, Tingting Li  ³, Donghui Yu  ⁴, Lei Jiang  ¹, Zhongqi Wan  ¹, Yunhong Luo  ¹, Tu Su  ¹, Jing Yu  ⁵, Yaoyan Qiu  ⁶ （Affiliations ¹ Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. ² Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. ³ Department of Ophthalmology, East Hospital, Tongji University School of Medicine, Shanghai, China. ⁴ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Department of Ophthalmology, The Third People's Hospital of Bengbu, Bengbu, China. Electronic address: 1300221@tongji.edu.cn. ⁶ Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. Electronic address: 522639875@qq.com.）

出处： Neuropharmacology 2025

关键词： Animal study;Mitochondrial biogenesis;Mitochondrial dysfunction;Retinitis pigmentosa;ZLN005.

摘要： Retinitis pigmentosa (RP) is a hereditary neurodegenerative disease characterized by the degeneration of photoreceptors caused by mutations in various ...

作者： Luni Zhang  ^{1   2}, Rong Wu  ^{1   2}, Jing Chen  ², Shiyao Gu  ², Caixia Jia  ² （Affiliations ¹ Department of Ultrasound, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. ² Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Ultrasonography (Seoul, Korea) 2025

关键词： Carotid artery diseases;Contrast-enhanced ultrasound;Intraplaque neovascularization;Ischemic stroke;Vulnerable plaque.

摘要： Purpose: There is still insufficient evidence for predicting stroke risk in patients with mild carotid atherosclerotic stenosis. This study aimed to e ...

作者： Xiang Chen  ¹, Yan Xing, Changcun Liu, Rui Zhang, Jinhua Zhao （Affiliation ¹ From the Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Clinical nuclear medicine 2025

摘要： A 27-year-old woman underwent 68 Ga-pentixafor PET/CT for primary aldosteronism localization and characterization. No functional adrenal nodules were ...

作者： Qing Wang  ¹, Ya Gao  ¹, Yanzheng Chen  ², Xuan Wang  ¹, Qingguo Pei  ¹, Taiyu Zhang  ³, Changping Wang  ⁴, Jinsong Pan  ¹ （Affiliations ¹ Department of Stomatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 201100, China. ³ Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ⁴ Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.）

出处： Advanced healthcare materials 2025

关键词： antibacterial activity;bone defect;implant;multifunctional surfaces;osteo‐immunomodulatory ability.

摘要： Bone implant-associated infections and inflammations, primarily caused by bacteria colonization, frequently result in unsuccessful procedures and pose ...

作者： Mingrui Chen  ¹, Guan Liu  ¹, Li Wang  ², Amin Zhang  ¹, Ziyang Yang  ¹, Xia Li  ³, Zhong Zhang  ³, Song Gu  ³, Daxiang Cui  ¹, Hossam Haick  ⁴, Ning Tang  ² （Affiliations ¹ School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. ² Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ³ Trauma Center in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ⁴ Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 3200003, Israel.）

出处： Analytical chemistry 2025

摘要： Interleukin-6 (IL-6) plays a pivotal role in the inflammatory response of diabetic wounds, providing critical insights for clinicians in the developme ...

作者： Liwen Zhong  ¹, Danjun Xu  ², Jingyi He  ², Lianhui Sun  ³, Guangjian Fan  ³, Ting Zhu  ³, Yufeng Yao  ⁴, Tingting Feng  ⁵, Zelin Cui  ⁶ （Affiliations ¹ Laboratory of Bacterial Pathogenesis, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Laboratory of Bacterial Pathogenesis, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yfyao@sjtu.edu.cn. ⁵ Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: ycttfeng@163.com. ⁶ Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: czl@sjtu.edu.cn.）

出处： International journal of medical microbiology : IJMM 2025

关键词： Antibodies;Dermal abscess;Exposure;Phage JD007;S. aureus;Therapeutic efficacies.

摘要： Objectives: phage therapy is a promising approach for infections caused by drug-resistant bacteria; this study evaluated the impact of pre-exposure to ...

作者： Chaoliang Xu ^{#  1}, Jingpiao Bao ^{#  2   3}, Deshen Pan  ¹, Kehong Wei  ¹, Qing Gao  ¹, Weihong Lin  ⁴, Yujie Ma  ⁴, Meiqing Lou  ⁵, Cheng Chang  ⁶, Deshui Jia  ¹ （Affiliations ¹ Department of Thoracic Surgery, Institute of Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China. ⁵ Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.）

出处： Translational lung cancer research 2025

关键词： ATF3;Lung adenocarcinoma (LUAD);brain metastasis (BrM);single-cell RNA sequencing (scRNA-seq);spatial transcriptomics (ST).

摘要： Background: Brain metastasis (BrM) has been a challenge for lung cancer treatment, but the mechanisms underlying lung cancer BrM remain elusive. This ...

作者： Yichao Ma  ^{1   2}, Jiangpeng Wu  ², Yanlong Dong  ³, Hongmei Tang  ¹, Xiaojun Ma  ² （Affiliations ¹ Shanghai University of Traditional Chinese Medicine, Shanghai, China. ² Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Linyan Medical Technology Company Limited, Shanghai, China.）

出处： Orthopaedic surgery 2025

关键词： accuracy;augmented reality;navigation;pedicle screw;thoracolumbar spine.

摘要： Objective: The pedicle screw insertion technique has evolved significantly, and despite the challenges of precise placement, advancements like AR-base ...

作者： Chunling Ren  ¹, Wanqi Chen  ¹, Yun Liao  ², Yangguang Huang  ³, Changlong Yu  ⁴, Ting Chen  ¹, Qingmei Zeng  ¹, Yunlong Yang  ², Rongkun Huang  ³, Tuan Liu  ¹, Li Jiang  ¹, Bingkun Bao  ¹, Linyong Zhu  ¹, Qiuning Lin  ¹ （Affiliations ¹ School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. ² Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. ⁴ Burn Plastic Wound Repair Surgery of Ganzhou Hospital of Guangdong Provincial People's Hospital, GanZhou, 341000, China.）

出处： Advanced materials (Deerfield Beach, Fla.) 2025

关键词： 3D printing;biomaterials;gelatin hydrogels;mechanical performance;tissue engineering.

摘要： Gelatin hydrogels (e.g., methacrylated gelatin gel, abbreviated GelMA gel) have garnered significant attention in tissue engineering and therapeutic d ...

作者： Zheng Zhang  ^{1   2}, Jiaxing Wang  ¹, Xiaofang Li  ¹, Lingzhou Zhao  ³, Junwei Zhao  ⁴, Mengjiao Su  ¹, Xiangxiang Wu  ¹, Huahui Zeng  ¹ （Affiliations ¹ Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Zhengzhou, China. ² Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou, China. ³ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Clinical Laboratory, Core Unit of National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.）

出处： Drug delivery 2025

关键词： Ginsenoside Rg3;celastrol;nanoparticles;pancreatic cancer;prodrug.

摘要： Celastrol (Cel) is a potential anticancer therapeutic candidate, but its limited practical applicability is due to its low solubility, poor tumor sele ...