作者： Anqi Lin  ¹, Lingxuan Zhu  ¹, Weiming Mou  ^{1   2}, Zizhi Yuan  ¹, Quan Cheng  ^{3   4}, Aimin Jiang  ⁵, Peng Luo  ¹ （Affiliations ¹ Department of Oncology, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue, Guangzhou, Guangdong, China. ² Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. ⁴ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. ⁵ Department of Urology, Changhai hospital, Naval Medical University (Second Military Medical University), Shanghai, China.）

出处： International journal of surgery (London, England) 2024

作者： Hangwei Chen  ¹, Fan Li  ², Yulong Ge  ¹, Junyi Liu  ¹, Xing Xing  ¹, Min Li  ², Zhilei Ge  ³, Xiaolei Zuo  ^{2   3}, Chunhai Fan  ^{2   3}, Shaopeng Wang  ², Fang Wang  ¹ （Affiliations ¹ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200800, China. ² Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. ³ School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.）

出处： Advanced materials (Deerfield Beach, Fla.) 2024

关键词： Dox delivery;atrial fibrillation;radiofrequency catheter ablation;tetrahedral DNA framework.

摘要： Preorganizing molecular drugs within a microenvironment is crucial for the development of efficient and controllable therapeutic systems. Here, the us ...

作者： Fengshuo Wang¹;Yongliang Fan²;Yue Liu¹;Xiangxin Lou¹;Linawati Sutrisno³;Shaojun Peng⁴;Jingchao Li¹ （¹State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Biological Science and Medical Engineering Donghua University Shanghai China;²Department of Cardiovascular Surgery Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai China;³World Premier International (WPI) Research Center for Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS) Tsukuba Japan;⁴Zhuhai Institute of Translational Medicine Zhuhai Precision Medical Center Zhuhai People's Hospital (Zhuhai hospital affiliated with Jinan University) Zhuhai Guangdong China）

出处： Exploration 2024

关键词： deep tumors;prodrug;pyroptosis;semiconducting polymer;sonodynamic therapy

摘要： Sonodynamic therapy (SDT) has been explored for cancer therapy, especially for deep tumors due to its low tissue penetration restriction. The therapeu ...

作者： Mengxue Li  ¹, Liqing Su  ¹, Jie Zhang  ², Lei Jia  ², Yumeng Zhang  ¹, Ziyi Zheng  ¹, Jian Chang  ^{3   4} （Affiliations ¹ Shanghai Jiao Tong University, School of Nursing, Shanghai, 200001, China. ² Department of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University, School of Nursing, 650 Xin Song Jiang Road, Songjiang District, Shanghai, 201620, China. ³ Shanghai Jiao Tong University, School of Nursing, Shanghai, 200001, China. changjiancn@sjtu.edu.cn. ⁴ Department of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University, School of Nursing, 650 Xin Song Jiang Road, Songjiang District, Shanghai, 201620, China. changjiancn@sjtu.edu.cn.）

出处： Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2024

关键词： Colorectal cancer;Elderly caregivers;Experience;Palliative chemotherapy;Spousal caregivers;Supportive care.

摘要： Purpose: Despite the increasing research on cancer patient caregivers, there is still a lack of detailed understanding about the experiences of spouse ...

作者： Hotin Wu  ^{1   2}, Bo Zhang  ¹, Jun Chen  ¹, Ziyi Qi  ^{1   2}, Xun Xu  ^{1   2}, Huo Li  ³, Xiangui He  ^{4   2} （Affiliations ¹ Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai, China. ³ Department of Electronic Engineering, Tsinghua University, Beijing, China. ⁴ Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China xianhezi@163.com.）

出处： The British journal of ophthalmology 2024

关键词： imaging;optics and refraction.

摘要： Aims: To quantitatively measure retinal curvature (RC) in children with myopia and explore its association with refractive status. Methods: This cross ...

作者： Yaoxin Gao  ¹, Weirong Zhan  ², Dandan Guo  ², Haizhen Lin  ², Muhammad Asad Farooq  ², Chenxu Jin  ², Li Zhang  ², Ying Zhou  ², Jie Yao  ², Yixin Duan  ², Cong He  ³, Shuai Jiang  ⁴, Wenzheng Jiang  ⁵ （Affiliations ¹ Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China; Biotherapy Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China. ² Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China. ³ Laboratory of Cancer Genomics and Biology, Department of Urology and Institute of Translational Medicine. Shanghai General Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁴ State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute Fudan University, Shanghai 200438, China. ⁵ Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China. Electronic address: wzjiang@bio.ecnu.edu.cn.）

出处： Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024

关键词： DCs;GPR97;Keratinocytes;Psoriasis;Th17 cells.

摘要： Skin psoriasis is defined as receiving external stimulation to activate skin dendritic cells (DCs) which can release interleukin 23 (IL-23) to interli ...

作者： Nianting Tong  ^{1   2   3}, Wenying Fan  ^{1   2   4}, Li Su  ^{1   2   5}, Adel Ebraheem  ^{1   2}, Akihito Uji  ^{1   2}, Kenneth Marion  ^{1   2}, Srinivas Sadda  ^{1   2} （Affiliations ¹ Doheny Eye Institute, Los Angeles, California. ² Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California. ³ Department of Ophthalmology, Qingdao Municipal Hospital, Qingdao, China. ⁴ Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China; and. ⁵ Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Retina (Philadelphia, Pa.) 2024

摘要： Purpose: To correlate baseline spectral-domain optical coherence tomography characteristics with the number of as-needed intravitreal injections of ra ...

作者： Shuli Chen  ¹, Xinran Qin  ¹, Yu Sun  ², Zhenlin Ma  ², Chen Niu  ², Yi Xu  ³, Lina Lu  ³, Haidong Zou  ^{1   3   4   5} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Shanghai MicroH Therapeutics, LLC, Shanghai, China. ³ Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. ⁴ Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ⁵ National Clinical Research Center for Eye Diseases, Shanghai, China.）

出处： FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024

关键词： arachidonic acid;diabetes;eicosanoids;epidemiology;high‐fat diet;inflammation;lipoxygenase;p38 MAPK pathway;retina;retinal microvascular endothelial cell.

摘要： 12-hydroxyeicosatetraenoic acid (12-HETE), a major metabolite of arachidonic acid, is converted by 12/15-lipoxygenase and implicated in diabetic retin ...

作者： Xing He  ¹, Haowei He  ¹, Zitong Hou  ¹, Zheyu Wang  ¹, Qinglin Shi  ¹, Tao Zhou  ¹, Yaoxing Wu  ², Yunfei Qin  ³, Jun Wang  ⁴, Zhe Cai  ⁵, Jun Cui  ¹, Shouheng Jin  ⁶ （Affiliations ¹ Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. ² Institute of Precision Medicine, Department of Critical Care Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. ³ Biotherapy Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. ⁴ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. ⁶ Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. jinshh3@mail.sysu.edu.cn.）

出处： The EMBO journal 2024

关键词： Colitis;ER-phagy;Inflammatory Responses;MARK2;UBAC2.

摘要： ER-phagy, a selective form of autophagic degradation of endoplasmic reticulum (ER) fragments, plays an essential role in governing ER homeostasis. Dys ...

作者： Jue Wang  ¹, Xiangshi Sun  ², Zhiwen Zhao  ¹, Guanru Wang  ², Dangge Wang  ³, Yaping Li  ⁴ （Affiliations ¹ State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. ² State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ³ Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: dg_wang@sjtu.edu.cn. ⁴ State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Shandong 264117, China. Electronic address: ypli@simm.ac.cn.）

出处： Journal of controlled release : official journal of the Controlled Release Society 2024

关键词： BRAF(V600E);Colorectal cancer;Copper depletion;Drug resistance;Hydrogel;Nanoparticles.

摘要： BRAF^V600E-mutant colorectal cancer (CRC) is resistant to most first-line therapeutics, including the BRAF inhibitor dabrafenib and epiderma ...