作者： Zhi-Chao Xi ^{#  1   2}, Han-Gui Ren ^{#  1   2}, Lin Ai  ³, Yuan Wang  ³, Meng-Fan Liu  ^{1   2}, Yu-Fei Qiu  ³, Ji-Ling Feng  ⁴, Wang Fu  ³, Qian-Qian Bi  ³, Feng Wang  ⁵, Hong-Xi Xu  ^{6   7} （Affiliations ¹ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. ² Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China. ³ Department of Neurology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. ⁴ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ⁵ Department of Neurology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. wangfengshutcm@163.com. ⁶ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. xuhongxi88@gmail.com. ⁷ Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China. xuhongxi88@gmail.com.）

出处： Acta pharmacologica Sinica 2025

作者： Qi Zhang  ^{1   2}, Xuliren Wang  ^{1   2}, Zhibo Shao  ^{1   2}, Yi Zhang  ^{1   2}, Liyi Zhang  ^{1   2}, Ming Chen  ^{1   2}, Xujie Zhou  ^{1   2}, Han Zhu  ¹, Yue Zhou  ^{1   2}, Xinya Lu  ^{1   2}, Pei Li  ^{1   2}, Weiru Chi  ^{1   2}, Lun Li  ^{1   2   3}, Zhi-Ming Shao  ^{1   2}, Shenglin Huang  ⁴, Jingyan Xue  ^{1   2}, Yayun Chi  ^{1   2   5}, Jiong Wu  ^{1   2   6}, Bingqiu Xiu  ^{1   2} （Affiliations ¹ Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. ² Department of Oncology, Fudan University Shanghai Medical College, Shanghai, 200032, China. ³ Department of General Surgery, The Second Xiangya Hospital, Central South University, Hunan, 410011, China. ⁴ Fudan University Shanghai Cancer Center, Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. ⁵ Pathology Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. ⁶ Collaborative Innovation Center for Cancer Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： ATR inhibitors;DNA replication licensing;HER2‐positive breast cancers;LINC01235;chromosomal instabilities.

摘要： Despite the development of HER2-targeting drugs such as trastuzumab and T-DXd, treatment resistance is a substantial challenge, often leading to relap ...

作者： Jie Xu  ¹, Haixin Wang  ², Min Lu  ³, Hai Bi  ⁴, Deng Li  ⁴, Zixuan Xue  ⁵, Qi Zhang  ⁶ （Affiliations ¹ School of Information Technology and Management, University of International Business and Economics, Beijing 100029, China. ² Cadre Medical Department, The 1st medical Center, Chinese PLA General Hospital, Beijing 100853, China. ³ Department of Pathology, School of Basic Medical Sciences, Peking University Third Hospital, Peking University Health Science Center, Beijing 100191, China. ⁴ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ⁵ Department of Urology, Peking University Third Hospital, Beijing 100191, China. ⁶ School of Information Technology and Management, University of International Business and Economics, Beijing 100029, China. Electronic address: zhangqi@uibe.edu.cn.）

出处： Computer methods and programs in biomedicine 2025

关键词： Deep learning;Medical information processing;Tumor segmentation;Uncertainty estimation.

摘要： Background and objective: Although deep learning-based intelligent diagnosis of bladder cancer has achieved excellent performance, the reliability of ...

作者： Jing Li  ¹, Shizhe Liu  ², Sunghwan Kim  ¹, Jacob Goell  ¹, Zachary Allen Drum  ³, John Patrick Flores  ³, Alex J Ma  ¹, Barun Mahata  ¹, Mario Escobar  ¹, Alex Raterink  ⁴, Jeong Hyun Ahn  ⁵, Erik R Terán  ², Rosa Selenia Guerra-Resendez  ⁴, Yuhao Zhou  ¹, Bo Yu  ⁶, Michael R Diehl  ^{1   7}, Gang Greg Wang  ^{5   8}, Anna-Karin Gustavsson  ^{2   4   7}, Douglas H Phanstiel  ³, Isaac B Hilton  ^{1   2   4} （Affiliations ¹ Department of Bioengineering, Rice University, Houston, TX, 77030, United States. ² Department of BioSciences, Rice University, Houston, TX, 77030, United States. ³ Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States. ⁴ Systems, Synthetic, and Physical Biology Graduate Program, Rice University, Houston, TX, 77030, United States. ⁵ Lineberger Comprehensive Cancer Center and Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, United States. ⁶ Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁷ Department of Chemistry, Rice University, Houston, TX, 77030, United States. ⁸ Department of Pharmacology and Cancer Biology and Duke Cancer Institute, Duke University, Durham, NC, 27710, United States.）

出处： Nucleic acids research 2025

摘要： Protein intrinsically disordered regions (IDRs) are critical gene-regulatory components and aberrant fusions between IDRs and DNA-binding/chromatin-as ...

作者： Shu-Juan Ni  ^{1   2}, Xin Wang  ^{1   2}, Lin Yuan  ³, Hui Dong  ⁴, Hui Sun  ^{1   2}, Cong Tan  ^{1   2}, Xu Cai  ^{1   2}, Wenhua Jiang  ^{1   2}, Weiqi Sheng  ^{1   2}, Midie Xu  ^{5   2}, Dan Huang  ^{5   2} （Affiliations ¹ Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China. ² Department of Oncology, Fudan University Shanghai Medical College, Shanghai, People's Republic of China. ³ Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China danhuang@shca.org.cn xumd27202003@sina.com yuanlin_li@126.com huidong@smmu.edu.cn. ⁴ Department of Pathology, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, People's Republic of China danhuang@shca.org.cn xumd27202003@sina.com yuanlin_li@126.com huidong@smmu.edu.cn. ⁵ Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China danhuang@shca.org.cn xumd27202003@sina.com yuanlin_li@126.com huidong@smmu.edu.cn.）

出处： Journal of clinical pathology 2025

关键词： Antibodies;Gallbladder Neoplasms;IMMUNOHISTOCHEMISTRY;Monoclonal.

摘要： Aims: Gallbladder carcinoma (GBC) is frequently diagnosed and treated in advanced stages and has a poor prognosis. Recent studies have identified clau ...

作者： Chengyu Hu  ¹, Chengda Ren  ², Yan Wu  ¹, Ruoyi Lin  ¹, Tianyi Shen  ¹, Tingting Li  ³, Donghui Yu  ⁴, Lei Jiang  ¹, Zhongqi Wan  ¹, Yunhong Luo  ¹, Tu Su  ¹, Jing Yu  ⁵, Yaoyan Qiu  ⁶ （Affiliations ¹ Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. ² Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. ³ Department of Ophthalmology, East Hospital, Tongji University School of Medicine, Shanghai, China. ⁴ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China; Department of Ophthalmology, The Third People's Hospital of Bengbu, Bengbu, China. Electronic address: 1300221@tongji.edu.cn. ⁶ Department of Ophthalmology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. Electronic address: 522639875@qq.com.）

出处： Neuropharmacology 2025

关键词： Animal study;Mitochondrial biogenesis;Mitochondrial dysfunction;Retinitis pigmentosa;ZLN005.

摘要： Retinitis pigmentosa (RP) is a hereditary neurodegenerative disease characterized by the degeneration of photoreceptors caused by mutations in various ...

作者： Luni Zhang  ^{1   2}, Rong Wu  ^{1   2}, Jing Chen  ², Shiyao Gu  ², Caixia Jia  ² （Affiliations ¹ Department of Ultrasound, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. ² Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Ultrasonography (Seoul, Korea) 2025

关键词： Carotid artery diseases;Contrast-enhanced ultrasound;Intraplaque neovascularization;Ischemic stroke;Vulnerable plaque.

摘要： Purpose: There is still insufficient evidence for predicting stroke risk in patients with mild carotid atherosclerotic stenosis. This study aimed to e ...

作者： Xiang Chen  ¹, Yan Xing, Changcun Liu, Rui Zhang, Jinhua Zhao （Affiliation ¹ From the Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Clinical nuclear medicine 2025

摘要： A 27-year-old woman underwent 68 Ga-pentixafor PET/CT for primary aldosteronism localization and characterization. No functional adrenal nodules were ...

作者： Qing Wang  ¹, Ya Gao  ¹, Yanzheng Chen  ², Xuan Wang  ¹, Qingguo Pei  ¹, Taiyu Zhang  ³, Changping Wang  ⁴, Jinsong Pan  ¹ （Affiliations ¹ Department of Stomatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 201100, China. ³ Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ⁴ Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.）

出处： Advanced healthcare materials 2025

关键词： antibacterial activity;bone defect;implant;multifunctional surfaces;osteo‐immunomodulatory ability.

摘要： Bone implant-associated infections and inflammations, primarily caused by bacteria colonization, frequently result in unsuccessful procedures and pose ...

作者： Mingrui Chen  ¹, Guan Liu  ¹, Li Wang  ², Amin Zhang  ¹, Ziyang Yang  ¹, Xia Li  ³, Zhong Zhang  ³, Song Gu  ³, Daxiang Cui  ¹, Hossam Haick  ⁴, Ning Tang  ² （Affiliations ¹ School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. ² Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ³ Trauma Center in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ⁴ Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 3200003, Israel.）

出处： Analytical chemistry 2025

摘要： Interleukin-6 (IL-6) plays a pivotal role in the inflammatory response of diabetic wounds, providing critical insights for clinicians in the developme ...