作者： Xiangui He  ^{1   2}, Nicola S Logan  ³, James S Wolffsohn  ³ （Affiliations ¹ Shanghai Eye Diseases Prevention and Treatment Centre, Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai, China. ³ School of Optometry, Aston University, Birmingham, UK.）

出处： Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 2025

作者： Da-Hong Chen^1,2;Peng-Juan Mao^1,2;Wen-Jing Diao¹;Jia-Qi Lu³;Shi-Lan Wu³;Qin Li^1,4CA1 （¹Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Shanghai, 200080, P. R. China;²DH Chen and PJ Mao contributed equally to this study.;³School of Pharmacy Shanghai University of Medicine & Health Sciences Shanghai China;⁴Shanghai Eye Diseases Prevention and Treatment Center/Shanghai Eye Hospital, School of Medicine, Tongji University, 200040, P. R. China）

出处： Journal of Ethnopharmacology 2025

关键词： Gastric cancer;Chinese herb;Hedyotis diffusa formula;Wnt/β-catenin signaling pathway;Compounds-target-disease

摘要： Ethnopharmacological relevance Due to the low early diagnosis rate and strong heterogeneity, gastric cancer (GC), a malignant tumor of the digestive t ...

作者： Meng Wang  ^{1   2}, Guangmin Zheng  ³, Xiaoyong Hu  ⁴, Feng Tian  ⁵, Tuo Li  ⁶, Zheng Zhang  ⁷, Kan Gong  ⁷, Shiwei Chen  ⁷, Lin Yuan  ⁸, Yu Qi  ⁸, Lin Li  ⁹, Daofu Cheng  ¹, Liu Liu  ¹⁰, Fuqiang Liu  ¹¹, Yujing Sun  ¹¹, Xiangdong Fang  ³, Ruxing Zhao  ¹¹, Bing Liu  ⁹, Chao Zhang  ¹ （Affiliations ¹ Department of Orthopedics and Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Department of Endocrinology, Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD), Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. ³ CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences/China National Center for Bioinformation, Beijing, 100101, China. ⁴ Department of Urology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200000, China. ⁵ Hebei Key Laboratory of Medical Data Science, Institute of Biomedical Informatics, School of Medicine, Hebei University of Engineering, Handan, Hebei Province, 056009, China. ⁶ Department of Endocrinology, Shanghai Changzheng Hospital, Shanghai, 200003, China. ⁷ Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Department of Urology, Peking University First Hospital, Peking University Health Science Center, Beijing, 100035, China. ⁸ Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ⁹ Department of Urology, Eastern Hepatobiliary Surgery Hospital, Shanghai, 201805, China. ¹⁰ Shanghai Yuhui Pharmaceutical Technology (Group) Co., Ltd., Shanghai, 201203, China. ¹¹ Department of Endocrinology and Metabolism, Qilu Hospital of Shandong University, Shandong Provincial Key Laboratory of Spatiotemporal Regulation and Precision Intervention in Endocrine and Metabolic Diseases, Shandong University, Jinan, 250012, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： SF1;adrenal incidentaloma;clusterin;imaging;immune microenvironment;scRNA‐seq.

摘要： Adrenal incidentalomas (AIs) are commonly detected endocrine lesions, identified during imaging for unrelated conditions. These lesions exhibit consid ...

作者： Feixiang Xu ^{#  1}, Chen Chen ^{#  1}, Su Lu ^{#  1}, Mingming Xue ^{#  1}, Hailin Ding ^{#  1}, Yanli Song ^{#  2}, Yun Zhang ^{#  3}, Keyu Sun ^{#  4}, Lunxian Tang  ⁵, Wei Wang  ⁶, Meitang Wang  ⁷, Yan Tang  ⁸, Dingyu Tan  ⁹, Chenling Yao  ¹, Dongwei Shi  ¹, Enqiang Mao  ¹⁰, Mian Shao  ¹, Youguo Ying  ¹¹, Chunmei Zhou  ¹², Lihong Huang  ¹³, Hu Peng  ¹⁴, Zhongshu Kuang  ¹, Sanqiang Wang  ¹, Qingbian Ma  ^{15   16}, Si Sun  ¹, Dongfeng Guo  ¹⁷, Tianwen Gu  ¹, Bin Yang  ¹⁸, Linhao Ma  ¹⁹, Chengjin Gao  ²⁰, Xiaoye Lu  ²¹, Hong Zhang  ²², Ruilan Wang  ²³, Chaoyang Tong  ²⁴, Zhenju Song  ^{25   26} （Affiliations ¹ Department of Emergency, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, Shanghai, 200032, China. ² Department of Emergency Internal Medicine, Tongji Hospital, Tongji University, Shanghai, China. ³ Department of Emergency Medicine, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu, China. ⁴ Department of Emergency, Minhang Hospital, Fudan University, Shanghai, China. ⁵ Department of Emergency Medicine and Critical Care, East Hospital, Tongji University, Shanghai, China. ⁶ Department of Emergency, Shanghai Xuhui Central Hospital, Shanghai, China. ⁷ Emergency Department, Changhai Hospital, Navy Medical University, Shanghai, China. ⁸ Department of Emergency, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China. ⁹ Department of Emergency, Northern Jiangsu People's Hospital, Yangzhou University, Jiangsu, China. ¹⁰ Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹¹ Emergency Department, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹² Department of Clinical Microbiology Laboratory, Zhongshan Hospital, Fudan University, Shanghai, China. ¹³ Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai, China. ¹⁴ Department of Emergency, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. ¹⁵ Emergency Department, Peking University Third Hospital, Beijing, China. ¹⁶ Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China. ¹⁷ Department of Emergency Medicine, Gongli Hospital, Shanghai, China. ¹⁸ Vision Medicals Center for Infectious Diseases, Guangzhou, China. ¹⁹ Department of Emergency and Critical Care Medicine, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Huangpu District, Shanghai, 200003, China. macro118@139.com. ²⁰ Department of Emergency, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Yangpu District, Shanghai, 200092, China. gaochengjin@xinhuamed.com.cn. ²¹ Department of Emergency, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 160 Pujian Road, Pudong District, Shanghai, 200127, China. luxiaoye@renji.com. ²² Department of Emergency Medicine, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Shushan District, Hefei, Anhui Province, 230032, China. zhanghong20070703@163.com. ²³ Department of Emergency and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Hongkou District, Shanghai, 200080, China. wangyusun@hotmail.com. ²⁴ Department of Emergency, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, Shanghai, 200032, China. tong.chaoyang@zs-hospital.sh.cn. ²⁵ Department of Emergency, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Xuhui District, Shanghai, 200032, China. song.zhenju@zs-hospital.sh.cn. ²⁶ Shanghai Institute of Infectious Disease and Biosecurity, Shanghai, China. song.zhenju@zs-hospital.sh.cn.）

出处： Journal of translational medicine 2025

关键词： 28-day mortality;Antibiotics;Conventional microbiological test;Etiological diagnosis;Inverse probability treatment weighting;Metagenomics next-generation sequencing;Sepsis.

摘要： Background: Clinical implications of metagenomics next-generation sequencing (mNGS) in sepsis have not been fully evaluated. This study aimed to deter ...

作者： Wenli Qiao ^{#  1}, Taisong Wang ^{#  1}, Hongyuan Yi  ², Xuebing Li  ³, Yang Lv  ², Chen Xi  ², Runze Wu  ², Ying Wang  ², Ye Yu  ⁴, Yan Xing  ⁵, Jinhua Zhao  ⁶ （Affiliations ¹ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. ² United Imaging Healthcare Group Co., Ltd, Shanghai, China. ³ Jincheng People's Hospital, Shanxi, China. ⁴ Hospital Affairs Office, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. qzlglc@163.com. ⁵ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. xy.1@163.com. ⁶ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. zhaojinhua1963@126.com.）

出处： EJNMMI physics 2025

关键词： Deauville score;Deep progressive reconstruction;Lymphoma;PET/CT;Reconstruction algorithm.

摘要： Background: A deep progressive learning method for PET image reconstruction named deep progressive reconstruction (DPR) method was developed and prese ...

作者： Kun Liu ^{#  1   2}, Yuchen Wang ^{#  1}, Zhidong Ye ^{#  3}, Zixuan Chen ^{#  1}, Yanyan Liang ^{#  4}, Feng Shen  ⁵, Xiangdong Meng  ⁵, Jian Liu  ⁵, Lichun Guan  ⁵, Wenyi Yang  ¹, Jingjing Hu  ⁶, Shiping Xu  ⁷, Hongli Li  ^{8   9} （Affiliations ¹ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Institute for Developmental and Regenerative Cardiovascular Medicine, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ³ Department of Cardiovascular Medicine, Dongtai People's Hospital, Jiangsu, China. ⁴ Department of International Medical Care Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Operation Room, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Department of Cardiovascular Medicine, Dongtai People's Hospital, Jiangsu, China. zhulinlian_0824@163.com. ⁸ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. drhonglili@126.com. ⁹ Department of Geriatrics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. drhonglili@126.com.）

出处： Cardiovascular toxicology 2025

关键词： Ascending aortic dilation;Dissection;NUP188;Serum proteomics.

摘要： Ascending aortic dilation (AAD) is a complex and life-threatening condition, representing a significant risk factor for acute aortic syndromes. Due to ...

作者： Shanbao Li  ¹, Lei Li  ¹, Junyong Weng  ², Zeping He  ¹, Jing Lu  ¹, Wanyue Cao  ¹, Fangbin Song  ¹, Zhonglin Zhu  ², Bingjie Guan  ¹, Jinyan Zhang  ¹, Junming Xu  ¹ （Affiliations ¹ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.）

出处： Transplantation 2025

摘要： Background: The role of tryptophan 2,3-dioxygenase2 (TDO2), a key enzyme in the L-tryptophan (Trp)-kynurenine (Kyn) pathway, in liver transplant immun ...

作者： Yueling Wang  ^{1   2}, Xuhui Fan  ³, Zai Luo  ¹, Qingguo Wang  ³, Yuan Fang  ¹, Chao Han  ¹, Zhengjun Qiu  ¹, Han Wang  ⁴, Chen Huang  ^{5   6} （Affiliations ¹ Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu, China. ³ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁴ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. han.wang@shsmu.edu.cn. ⁵ Department of Gastrointestinal Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. huangchen0204@sjtu.edu.cn. ⁶ The Affiliated Chuzhou Hospital of Anhui Medical University, Chuzhou, 239000, Anhui, China. huangchen0204@sjtu.edu.cn.）

出处： La Radiologia medica 2025

关键词： Computed tomography;Gastric cancer;Perineural invasion;Radiomics.

摘要： Background: Perineural invasion (PNI) is closely related to the prognosis of gastric cancer (GC) patients. However, a noninvasive tool for accurately ...

作者： Yifan Sun ^{#  1}, Beifen Zhong ^{#  1}, Zizhou Meng ^{#  1}, Yuxiang Zhang  ¹, Zheng Li  ^{2   3}, Chencheng Yao  ⁴ （Affiliations ¹ Department of Andrology, Shanghai Key Laboratory of Reproductive Medicine, The Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Department of Andrology, Shanghai Key Laboratory of Reproductive Medicine, The Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. lizhengboshi@sjtu.edu.cn. ³ State Key Laboratory of Reproductive Medicine and Offspring Health, School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Taizhou, 225300, China. lizhengboshi@sjtu.edu.cn. ⁴ Department of Andrology, Shanghai Key Laboratory of Reproductive Medicine, The Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. yaochencheng@126.com.）

出处： Basic and clinical andrology 2025

关键词： AZFa microdeletion;Azoospermia;Congenital bilateral absence of the vas deferens;Cystic fibrosis transmembrane conductance regulator gene;Spermatogenesis.

摘要： Background: Azoospermia, the most severe form of male infertility, is categorized into two types: non-obstructive azoospermia (NOA) and obstructive az ...

作者： Siyuan Qian  ^{1   2}, Xuan Wang  ^{1   2   3}, Yishun Guo  ^{1   2}, Wenfang He  ^{2   3}, Jianhua Yang  ^{2   3}, Hao Chen  ^{1   2}, Renlong Li  ^{2   3}, Lili Su  ^{2   3}, Xinyi Wang  ^{1   2   3}, Yi Shao  ⁴, Bailiang Wang  ^{1   2   3} （Affiliations ¹ National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325000, China. ² State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. ³ NMPA Key Laboratory for Clinical Research and Evaluation of Medical Devices and Drug for Ophthalmic Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. ⁴ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai, 200080, China.）

出处： Advanced materials (Deerfield Beach, Fla.) 2025

关键词： endotoxin neutralization;infectious keratitis;lipopolysaccharide;proinflammatory cytokines;sterilization.

摘要： In the treatment of infectious keratitis, therapeutic strategies often prioritize enhancing bactericidal efficacy. However, endotoxins released from G ...