作者： Junzhe Xie  ¹, Chunlian Zhang  ², Jifeng Fan  ², Xiaoyun Feng  ^{3   4} （Affiliations ¹ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Dongjing Town Community Health Service Center, Shanghai, China. ³ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xiaoyun.feng@shgh.cn. ⁴ Department of Endocrinology and Metabolism, Jiading Branch of Shanghai General Hospital，Shanghai Jiao Tong University School of Medicine, Shanghai, China. xiaoyun.feng@shgh.cn.）

出处： Scientific reports 2026

关键词： Elderly;Renal function;TFQI;TSHI;TT4RI;Thyroid hormone sensitivity;eGFR.

摘要： Thyroid hormone sensitivity indices include thyroid feedback quantile-based index (TFQI), thyroid-stimulating hormone index (TSHI), and thyrotroph T4 ...

作者： Mingli Du ^{#  1}, Lei Ye ^{#  1}, Qitong Zhang ^{#  2}, Xianfeng Yao  ¹, Jiahao Mi  ¹, Li Li  ¹, Zefeng Zou  ¹, Xiaofeng Lu  ², Juan Xu  ², Jun Li  ³, Shaowen Liu  ⁴, Songwen Chen  ⁵ （Affiliations ¹ Department of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No 100, Haining Road, Shanghai, 200080, China. ³ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No 100, Haining Road, Shanghai, 200080, China. junli@shsmu.edu.cn. ⁴ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No 100, Haining Road, Shanghai, 200080, China. shaowen.liu@hotmail.com. ⁵ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No 100, Haining Road, Shanghai, 200080, China. chensongwen@shsmu.edu.cn.）

出处： BMC cardiovascular disorders 2026

关键词： Atrial fibrillation;Catheter ablation;Pain experience;Patient care;Psychological resilience.

摘要： Objectives: This study was performed to evaluate the current status and to analyze the associated factors of intraoperative pain experience during rad ...

作者： Yaping Zhang ^{# 1}, Ai Wang ^{# 2}, Qingyao Li ³, Lu Zhang ¹, Lingyun Wang ¹, Zhijie Pan ¹, Yanfei Hu ¹, Xueqian Xie ^{4 5} （Affiliations ¹ Radiology Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Haining Rd. 100, Shanghai, 200080, China. ² Radiology Department, Shanghai General Hospital of Nanjing Medical University, Haining Rd. 100, Shanghai, 200080, China. ³ School of Health Science and Engineering, University of Shanghai for Science and Technology, Jun Gong Rd. 516, Shanghai, 200093, China. ⁴ Radiology Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Haining Rd. 100, Shanghai, 200080, China. xiexueqian@hotmail.com. ⁵ Radiology Department, Shanghai General Hospital of Nanjing Medical University, Haining Rd. 100, Shanghai, 200080, China. xiexueqian@hotmail.com.）

出处： Japanese journal of radiology 2026

关键词： Artificial intelligence;Diagnostic imaging;Image enhancement;Lung nodule;X-ray computed tomography.

摘要： Purpose: Clear visualization and diagnosis of lung nodules depend on the spatial resolution of CT images. Transformer-based generative neural networks ...

作者： Meihua Zhao¹;Xisheng Yu²;Meizeng Zhao³;Guoqing Zhang¹CA1 （¹Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai 201803, P.R.China;²College of Mechanical Engineering, Donghua University, Shanghai 201620, China;³Department of Internal Medicine, Xinjiang Uygur Autonomous Region Rehabilitation Hospital, Urumqi, Xinjiang Uygur Autonomous Region 830000, China）

出处： Journal of Infection and Chemotherapy 2026

摘要： Objectives This study aims to assess the impact of metagenomic next-generation sequencing (mNGS) on optimizing diagnostic-therapeutic pathways for low ...

作者： Yun-Xi Ma  ¹, Yan-Ke Zhang  ², Jun Li  ³, Bing-Lin Zhu  ⁴ （Affiliations ¹ Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ² Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, the Army Medical University (Third Military Medical University), Chongqing, China. ⁴ Jinfeng Laboratory, Chongqing, China.）

出处： Journal of neurochemistry 2026

关键词： ANK2;PTBP2;RPE cells;Transdifferentiation;alternative splicing.

摘要： Direct lineage reprogramming represents a promising strategy to convert somatic cells into neurons, offering regenerative potential. While transcripti ...

作者： Huan Wang ¹, Yunguang Li ², Shijie Tang ³, Yikai Li ¹, Yehan Zhang ³, Xiaoyi Yin ⁴, Juan He ³, Yiqin Zhu ⁵, Yi Zhang ⁵, Xiaohan Shi ¹, Maoyuan Sun ⁶, Suizhi Gao ¹, Bo Li ¹, Lingyu Zhu ¹, Shuai Yuan ¹, Yaqi Pan ¹, Meilong Shi ¹, Penghao Li ¹, Chuanqi Teng ¹, Chaoliang Zhong ¹, Xiaolu Yang ¹, Zhendong Fu ¹, Xinyu Liu ¹, Xiaochao Kang ¹, Yining Kang ¹, Wenjie Li ¹, Kailian Zheng ¹, Bin Song ¹, Wei Jing ¹, Xiongfei Xu ¹, Shiwei Guo ⁷, Luonan Chen ⁸, Dong Gao ⁹, Gang Jin ¹⁰ （Affiliations ¹ Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China. ² Shanghai General Hospital, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: yunguang.li@sibcb.ac.cn. ³ Shanghai General Hospital, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. ⁴ Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China; Department of Pathology, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China. ⁵ Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China. ⁶ Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China. ⁷ Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China. Electronic address: gestwa@163.com. ⁸ Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310024, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Electronic address: lnchen@sibcb.ac.cnM. ⁹ Shanghai General Hospital, State Key Laboratory of Systems Medicine for Cancer, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Key Laboratory of Multi-Cell Systems, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China; Shanghai Academy of Natural Sciences (SANS), Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: dong.gao@sibcb.ac.cn. ¹⁰ Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, Second Military Medical University (Naval Medical University), Shanghai 200433, China. Electronic address: jingang@smmu.edu.cn.）

出处： Cancer letters 2026

摘要： Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to intrinsic and acquired chemotherapy resistance, particularly after neoadjuvant th ...

作者： Shuqi Wu ¹, Chenxi Deng ^{1 2}, Chaofan Fan ³, Qiheng Liang ^{1 4}, Lingxuan Zhu ¹, Weiming Mou ⁵, Hongsen Huang ^{1 6}, Keren Wu ^{1 2}, Yizhang Li ^{1 2}, Gengwen Deng ^{1 6}, Liling Xu ^{1 2}, Jiarui Xie ^{1 4}, Chenglin Hong ^{1 4}, Yuhang Deng ^{1 2}, Xingjian Li ^{1 6}, Changda Wu ^{1 2}, Tao Yang ⁷, Peng Luo ¹, Hank Z H Wong ⁸, Aimin Jiang ⁹, Anqi Lin ¹, Xin Chen ³, Minghua Ren ^{1 2 3 4 5 6 7 8 9} （Affiliations ¹ Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com. ² The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com. ³ Department of Pulmonary and Critical Care Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com. ⁴ School of Stomatology, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com. ⁵ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, shsmu.edu.cn. ⁶ The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China, fimmu.com. ⁷ Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn. ⁸ Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China, hku.hk. ⁹ Department of Urology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, China, chhospital.com.cn.）

出处： Human mutation 2026

关键词： FOXO-mediated transcription pathway;immune checkpoints;immune infiltration;immunotherapy;non–small cell lung cancer.

摘要： Background: Non-small cell lung cancer (NSCLC), accounting for 80% of lung cancer cases, remains a leading cause of cancer-related mortality globally. ...

作者： Beijie Qi ^{# 1}, Weihan Yu ^{# 2}, Hanyi Wang ^{# 2}, Yuqi Li ², Shuang Deng ¹, Chengqing Yi ¹ （Affiliations ¹ Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China. ² Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China.）

出处： Frontiers in cell and developmental biology 2026

关键词： fibrosis;macrophage-myofibroblast transition;multi-omics;periostin;shoulder stiffness.

摘要： Background: Shoulder stiffness (SS) is a fibrotic disease with pain and reduced range of motion (ROM). The pathogenesis of SS remains unclear. Recent ...

作者： Lushun Yuan ^{# 1 2}, Jihee Han ^{# 3}, Shuzhen Cheng ⁴, Frits R Rosendaal ³, Dennis O Mook-Kanamori ^{3 5}, J Wouter Jukema ^{6 7}, Hans Vink ⁸, Bernard M van den Berg ², Ton J Rabelink ², Astrid van Hylckama Vlieg ³, Uwe J F Tietge ^{9 10}, Ko Willems van Dijk ^{11 12 13}, Ruifang Li-Gao ³ （Affiliations ¹ Department of Vascular Surgery, Intervention Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, People's Republic of China (L.Y.). ² Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Nephrology (L.Y., B.M.v.d.B., T.J.R.), Leiden University Medical Center, the Netherlands. ³ Department of Clinical Epidemiology (J.H., F.R.R., D.O.M.-K., A.v.H.V., R.L.-G.), Leiden University Medical Center, the Netherlands. ⁴ National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing (S.C.), Dalian Polytechnic University, People's Republic of China. ⁵ Department of Public Health and Primary Care (D.O.M.-K.), Leiden University Medical Center, the Netherlands. ⁶ Department of Cardiology (J.W.J.), Leiden University Medical Center, the Netherlands. ⁷ Netherlands Heart Institute, Utrecht (J.W.J.). ⁸ Glycocalyx Research Institute, Alpine, UT (H.V.). ⁹ Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden (U.J.F.T.). ¹⁰ Clinical Chemistry, Karolinska University Laboratory, Karolinska University Hospital, Stockholm, Sweden (U.J.F.T.). ¹¹ Department of Human Genetics (K.W.v.D.), Leiden University Medical Center, the Netherlands. ¹² Division of Endocrinology, Department of Internal Medicine (K.W.v.D.), Leiden University Medical Center, the Netherlands. ¹³ Leiden Laboratory for Experimental Vascular Medicine (K.W.v.D.), Leiden University Medical Center, the Netherlands.）

出处： Arteriosclerosis, thrombosis, and vascular biology 2026

关键词： antioxidants;cardiovascular diseases;thrombin;triglycerides;venous thromboembolism.

摘要： Background: Recent evidence points to connections between HDLs (high-density lipoproteins), the coagulation system, and venous thromboembolism occurre ...

作者： Yang Fu ¹, Binqiang Xu ², Wenfei Qin ³, Wei Xiao ⁴, Huizhen Huang ², Jia Hu ², Mengyan Cui ², Qixiang Mei ², Junjie Fan ⁵, Chunlan Huang ⁶, Yue Zeng ⁷ （Affiliations ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China; Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China; Department of Gastroenterology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001 China. ² Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China; Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ³ School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. ⁴ School of Health Science and Engineering, Shanghai Engineering Research Center of Food Microbiology, University of Shanghai for Science and Technology, Shanghai 200093, China. ⁵ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China; Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: 956937215@qq.com. ⁶ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China; Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: chunlan.huang@shgh.cn. ⁷ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China; Institute of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: carrie_1004@sjtu.edu.cn.）

出处： Cellular and molecular gastroenterology and hepatology 2026

关键词： Blautia coccoides;acute pancreatitis;bile salt hydrolase;deoxycholic acid;farnesoid X receptor.

摘要： Background & aims: Gut dysbiosis is involved in the pathogenesis of acute pancreatitis (AP), yet therapeutic interventions remain limited. Our previou ...