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作者: Xia Sheng #  1, Chunmei Zhang #  1, Jiwei Zhao #  1, Jianping Xu  2, Peng Zhang  3, Quanju Ding  4, Jingfa Zhang  5   6   7   8   9 (Affiliations 1 People's Hospital of Huangdao District, Qingdao, Shandong Province, China. 2 People's Hospital of Huangdao District, Qingdao, Shandong Province, China. 13869860309@163.com. 3 People's Hospital of Huangdao District, Qingdao, Shandong Province, China. zhangpeng27309@126.com. 4 People's Hospital of Huangdao District, Qingdao, Shandong Province, China. 16678657089@163.com. 5 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. 13917311571@139.com. 6 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, National Clinical Research Center for Eye Diseases, Shanghai, China. 13917311571@139.com. 7 The International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China. 13917311571@139.com. 8 C-MER (Shenzhen) Dennis Lam Eye Hospital, Shenzhen, China. 13917311571@139.com. 9 C-MER International Eye Care Group, C-MER Dennis Lam & Partners Eye Center, Hong Kong, China. 13917311571@139.com.)

出处: Cell & bioscience 2024

关键词: Diabetic retinopathy;Endothelial cell;Inner blood-retinal barrier;Microvascular destabilization;Neurovascular unit;Pericyte.

摘要: Microvascular destabilization is the primary cause of the inner blood-retinal barrier (iBRB) breakdown and increased vascular leakage in diabetic reti ...

作者: Sun, Zhongshanga,b,c,d;Guo, Yuechengc,d;Xu, Xianjunc,d;Zhou, Cuic,d;Luo, Xinc,d;Shen, Zhenyangc,d;Shen, Boc,d;Wang, Junjunc,d;Lu, Jingyic,d;Zhang, Qingqingc,d;Shen, Feifeie;Yu, Louc;Ye, Yanpingf;Zhang, Lingf;Luo, Yingf;Qu, Yingc,d;Cai, Xiaoboc,dCAa;Dong, Huic,dCAb;Lu, Lungena,c,dCAcaDepartment of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China;bDepartment of Gastroenterology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China;cDepartment of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;dShanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China;eDepartment of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;fContinent Pharmaceuticals Co., Ltd, Beijing, China)

出处: Journal of Gastroenterology and Hepatology (Australia) 2024

关键词: apoptosis;endoplasmic reticular stress;hepatic stellate cell;hydronidone;mitochondrial apoptotic pathway

摘要: Background and Aim: Hydronidone (HDD) is a novel pirfenidone derivative developed initially to reduce hepatotoxicity. Our previous studies in animals ...

作者: Hongjie Chen #  1, Peng Lai #  1, Haiming Lu #  1, Jun Zhu  2, Weilin Sang  1, Cong Wang  1, Yiming Zhong  3, Libo Zhu  4, Jinzhong Ma  5 (Affiliations 1 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 2 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. 3 Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, China. 4 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. libozhu2018@163.com. 5 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. majinzhong1963@sina.com.)

出处: Journal of orthopaedic surgery and research 2024

关键词: COVID-19;Case-crossover study;Groin pain;Total hip arthroplasty (THA).

摘要: Background: The coronavirus disease 2019 (COVID-19) rapidly spreads worldwide and causes more suffering. The relation about the aggravation of inguina ...

作者: Hu, Guangyia,c,d,e;Gu, Lipingb;Wang, Ruonana,c,d,e;Jian, Qizhia,c,d,e;Lv, Kangjiaa,c,d,e;Xia, Mengxuea,c,d,e;Lai, Mengyub;Shen, Tingtingb;Hu, Jinga,c,d,e;Yang, Senf,g;Ye, Cunqif,g;Zhang, Xiaonana;Wang, YufanbCAa;Xu, Xuna,c,d,eCAb;Zhang, Fanga,b,c,d,eCAcaNational Clinical Research Center for Eye Diseases, Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;bDepartment of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;cEye Institute of Shanghai Jiao Tong University School, Shanghai, 200080, China;dShanghai Key Laboratory of Fundus Diseases, Shanghai, 200080, China;eShanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China;fZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, 310058, China;gKidney Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China)

出处: Science Bulletin 2024

关键词: Biomarker;Biomarker-based treatment;Diabetic retinopathy;Ethanolamine;Glucose-well-controlled diabetic patients;HbA1c

摘要: Diabetic retinopathy (DR) is the leading cause of blindness among the working-age population. Although controlling blood glucose levels effectively re ...

作者: Suqin Ben #  1   2, Fengying Gao #  3, Ziheng Xu #  1, Rulin Zhang  4, Xingyi Zhang  1, Ning Wang  2, Min Zhang  5, Lili Hou  6   7 (Affiliations 1 Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 HainingRoad, Hongkou District, Shanghai, 200080, China. 2 Department of Infectious Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. 3 Department of Pulmonary Disease, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, PR China. 4 Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 5 Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 HainingRoad, Hongkou District, Shanghai, 200080, China. maggie_zhangmin@163.com. 6 Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 HainingRoad, Hongkou District, Shanghai, 200080, China. Lilihoush@163.com. 7 Department of Respiratory and Critical Care Medicine, Jiuquan Branch of Shanghai General Hospital, Gansu, 735099, China. Lilihoush@163.com.)

出处: Virology journal 2024

关键词: Basophiles;Hematological parameters;Omicron;SARS-CoV-2.

摘要: Background: Omicron variants are currently the predominant circulating lineage worldwide and most cases are mild or asymptomatic. The Omicron variant ...

作者: Hui Huang  1   2, Yi Zheng  3, Meiqi Chang  4, Jun Song  2, Lili Xia  2, Chenyao Wu  2, Wencong Jia  2, Hongze Ren  2, Wei Feng  1   2, Yu Chen  1   2 (Affiliations 1 School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, P. R. China. 2 Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China. 3 Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P. R. China. 4 Laboratory Center, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P. R. China.)

出处: Chemical reviews 2024

摘要: Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typ ...

作者: Huahui Zeng  1   2, Xiaohu Zeng  1, Can Wang  1   2, Guoqiang Wang  1, Qikang Tian  1, Junwei Zhao  3, Lingzhou Zhao  4, Ruiqin Li  1, Ying Luo  2, Haotian Peng  1, Zhenqiang Zhang  5, Xiaofang Li  6, Xiangxiang Wu  7 (Affiliations 1 Academy of Chinese Medicine Science, Henan University of Chinese Medicine, Zhengzhou, 450046, China. 2 Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan Province, Zhengzhou, 450046, China. 3 Department of Clinical Laboratory, Core Unit of National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450046, China. 4 Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 5 Academy of Chinese Medicine Science, Henan University of Chinese Medicine, Zhengzhou, 450046, China. ZQzhang111@outlook.com. 6 Academy of Chinese Medicine Science, Henan University of Chinese Medicine, Zhengzhou, 450046, China. drlxf2080@163.com. 7 Academy of Chinese Medicine Science, Henan University of Chinese Medicine, Zhengzhou, 450046, China. wuxx-415@126.com.)

出处: Drug delivery and translational research 2024

关键词: Breast cancer;Celastrol;Combination therapy;Drug resistance;Taxol.

摘要: The resistance of malignant tumors to multiple drugs is a significant obstacle in cancer treatment and prognosis. Accordingly, we synthesized a celast ...

作者: Yue Wang1,2,3,4,5;Jun Liu6,7,5;Hongyan Cui8;Liuwei Zhang8;Zhen Li9;Xiumei Wang6;Jing Wang10CA1;Qixian Chen8CA2;Yan Zhao1,2,3CA31Department of Gastric Surgery, Cancer Hospital of Dalian University of Technology, No. 44 Xiaoheyan Road, Dadong District, Shenyang, Liaoning, 110042, China;2Department of Gastric Surgery, Cancer Hospital of China Medical University, No. 44 Xiaoheyan Road, Dadong District, Shenyang, Liaoning, 110042, China;3Provincial Key Laboratory of Interdisciplinary Medical Engineering for Gastrointestinal Carcinoma, Liaoning Cancer Hospital & Institute, No. 44 Xiaoheyan Road, Dadong District, Shenyang, Liaoning, 110042, China;4China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang City, Liaoning Province 110122, China;5These two authors contributed equally in this work.;6School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China;7Jiaxing Qingzhun Pharmaceutical Technology Co., Ltd, Western Kechuang Bay Valley, Tongxiang Town, Jiaxing, Zhejiang, 314500, China;8Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, Zhejiang, 314100, China;9College of Pharmacy, Dalian Medical University, No. 9 West Section Lvshun South Road, Dalian, Liaoning, 116044, China;10Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China)

出处: Biomaterials 2024

摘要: The surface physiochemical properties of nanomedicine play a crucial role in modulating biointerfacial reactions in sequential biological compartments ...

作者: He, XianguiaCAaaShanghai Eye Disease Prevention and Treatment Center, Tongji University Affiliated Eye Hospital, Shanghai General Hospital of Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai, 201103, China)

出处: Chinese Journal of Ophthalmology 2024

关键词: Child;Early diagnosis;Myopia;Pre‑exposure prophylaxis;Refractive errors

摘要: The International Myopia Institute introduced the concept of 'pre‑myopia' in 2019, defining it as children with refractive error ≤+0.75 D and >-0.50 D ...

作者: Wanheng Zhang  1   2, Yan Hou  1   3, Shiyi Yin  2, Qi Miao  2, Kyubae Lee  4, Xiaojian Zhou  5, Yongtao Wang  6   7 (Affiliations 1 Institute of Geriatrics, School of Medicine, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Shanghai, 200444, China. 2 Department of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. 3 Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China. 4 Department of Biomedical Materials, Konyang University, Daejeon, 35365, Republic of Korea. 5 Department of Pediatrics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. zhouxiaojian504@hotmail.com. 6 Institute of Geriatrics, School of Medicine, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai University, Shanghai, 200444, China. yongtao_wang@shu.edu.cn. 7 Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), Shanghai University, Shanghai, 200444, China. yongtao_wang@shu.edu.cn.)

出处: Journal of nanobiotechnology 2024

关键词: Advanced gene/Drug nanocarriers;Cancer-resected tissue repair;Gene therapy;Nonviral-mediated delivery system;Tissue regeneration.

摘要: Tissue regeneration technology has been rapidly developed and widely applied in tissue engineering and repair. Compared with traditional approaches li ...

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