作者： Zhiwen Deng ^{#  1   2}, Liangyu Zhao ^{#  1   3   4}, Sha Li ^{#  1   2}, Xiaoyang Chen  ^{1   2}, Xiaohan Ling  ^{1   2}, Jiajun Zheng  ^{1   2}, Kunkun Yu  ^{1   2}, Jing Xu  ¹, Chencheng Yao  ³, Sha Han  ³, Jiayi Liang  ¹, Huimin Feng  ¹, Lanlan Wu  ¹, Peng Li  ³, Ruhui Tian  ³, Tao Jing  ^{3   5}, Yuxin Tang  ⁴, Yingbo Dai  ⁴, Minbo Yan  ⁴, Chenchen Wang  ⁶, Zheng Li  ⁷, Zhi Zhou  ^{8   9} （Affiliations ¹ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. ² Shanghai Clinical Research and Trial Center, Shanghai, China. ³ Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Urology, Department of Interventional Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China. ⁵ Department of Andrology, the Affiliated Hospital of Qingdao University, Qingdao, China. ⁶ Shanghai Advanced Research Institute, Stem Cell and Reproductive Biology Laboratory, Chinese Academy of Sciences, Shanghai, China. chenchenwang@pku.org.cn. ⁷ Department of Andrology, the Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lizhengboshi@sjtu.edu.cn. ⁸ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. zhouzhi@shanghaitech.edu.cn. ⁹ Shanghai Clinical Research and Trial Center, Shanghai, China. zhouzhi@shanghaitech.edu.cn.）

出处： Nature aging 2024

摘要： Age-related changes in testicular function can impact health and well-being. The mechanisms underlying age-related testicular dysfunction, such as lat ...

作者： Haoran Xia¹;Han Zhang¹;Zheng Ruan²;Huibiao Zhang³;Liangdong Sun¹;Hezhong Chen⁴;Yongxin Zhou⁵;Lele Zhang⁶;Dongliang Bian¹;Xinsheng Zhu¹;Jing Zhang¹;Fenghuan Sun¹;Huansha Yu⁷;Nan Song¹;Xiaogang Liu¹;Yuming Zhu¹;Haiping Zhang⁸;Wenxin He¹;Jian Chen¹;Jie Yang¹;Guohan Chen⁹;Shiliang Xie⁵;Dongfang Tang³;Xiaomiao Zhang²;Liang Duan¹;Deping Zhao¹CA1;Qinchuan Li⁹CA2;Peng Zhang¹CA3;null;Gening Jiang¹CA4 （¹Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;²Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;³Department of Thoracic Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China;⁴Department of Thoracic Surgery, Changhai Hospital, Naval Medical University, Shanghai, China;⁵Department of Thoracic-Cardiovascular Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai, China;⁶Central Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;⁷Experimental Animal Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;⁸Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China;⁹Department of Thoracic Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China）

出处： Signal Transduction and Targeted Therapy 2024

摘要： This multicentre, two-arm, phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patient ...

作者： Ru Wang  ¹, Haidong Cai  ¹, Changcun Liu  ², Zhongwei Lv  ¹, Chao Ma  ¹ （Affiliations ¹ From the Department of Nuclear Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University. ² Department of Nuclear Medicine, Shanghai First People Hospital, Jiao Tong University School of Medicine, Shanghai, China.）

出处： Clinical nuclear medicine 2024

摘要： The concurrence of Hodgkin lymphoma and papillary thyroid carcinoma is a rare clinical event. Two women presented with a painless mass in the neck tha ...

作者： Yiting Li ^{#  1}, Xi Tan ^{#  1}, Shu Nie  ¹, Xin Tian  ², Zhouwei Wu  ³ （Affiliations ¹ Department of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Institute of Dermatology, Guangzhou Medical University, Guangzhou, China, and Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou, China. xinzisue@163.com. ³ Department of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhouwei.wu@shgh.cn.）

出处： Acta dermato-venereologica 2024

作者： Jiali Wu  ¹, Ning Wang  ² （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Wujin Road No.85, Hongkou district, Shanghai, 200080, China. ² Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Wujin Road No.85, Hongkou district, Shanghai, 200080, China. drwang_ning@163.com.）

出处： BMC ophthalmology 2024

关键词： Amblyopia;Refractive error;Strabismus;Visual impairment.

摘要： Background: Functional visual impairments in children are primarily caused by amblyopia or strabismus. This study aimed to determine the prevalence an ...

作者： Jingjing Jiang  ¹, Ru Cheng  ¹, Aoqi Song  ¹, Yuefen Lou  ², Guorong Fan  ³ （Affiliations ¹ Department of Pharmacy, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China. ² Department of Pharmacy, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, 200434, China. louyuefen@sina.cn. ³ Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. fanguorong@sjtu.edu.cn.）

出处： Functional & integrative genomics 2024

关键词： Acteoside;Epithelial-mesenchymal transition;Extracellular regulated kinases 1/2 pathway;Liver cancer;Schisandra chinensis lignans.

摘要： Background: Hepatocellular carcinoma (HCC), a globally common cancer, often presents late and shows high resistance to chemotherapy, resulting in subo ...

作者： Rui Guo  ^{1   2}, Biao Ding  ³, Kaiqin Hu  ^{1   2}, Kai Wang  ^{1   2}, Dongdong Tang  ², Xuegu Wang  ³, Junpei Sun  ³, KuoKuo Li  ^{1   2}, Huiru Cheng  ^{1   2}, Chuan Xu  ², Miao Sun  ⁴, Likui Lu  ², Mingxi Liu  ⁵, Yunxia Cao  ^{1   2}, Xiaoyu Yang  ⁶, Xiaojin He  ^{1   7} （Affiliations ¹ NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui, China. ² Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. ³ Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China. ⁴ Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, China. ⁵ State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China. ⁶ State Key Laboratory of Reproductive Medicine, The Center for Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. ⁷ Department of Obstetrics and Gynecology, Reproductive Medicine Center, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.）

出处： Andrology 2024

关键词： TDRD5 variants;oligoasthenoteratozoospermia;pirna;spermiogenesis;whole exome sequencing.

摘要： Background: PiRNA pathway factors, including evolutionarily conserved Tudor domain-containing proteins, play crucial roles in suppressing transposons ...

作者： Chuanhe Jiang  ¹, Jingtao Huang  ¹, Jie Shao  ², Tingting Yang  ³, Ye Zhao  ⁴, Meijuan Huang  ⁵, Hongmei Yi  ⁶, Jimin Shi  ³, Liping Wan  ², Feng Chen  ⁴, Yang Cao  ⁵, Xiaoxia Hu  ¹ （Affiliations ¹ Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. ⁴ National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. ⁵ Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ⁶ Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Cell transplantation 2024

关键词： EBV;T-PTLD;allo-HSCT;poor prognosis.

摘要： Posttransplant lymphoproliferative disorder (PTLD) is a rare lymphoid and/or plasmocytic proliferation that occurs after allogeneic hematopoietic stem ...

作者： Feng Gao ^{#  1}, Liren Jiang ^{#  1}, Tuanjie Guo ^{#  2}, Jun Lin ^{#  1}, Weiqing Xu ^{#  1}, Lin Yuan  ¹, Yaqin Han  ¹, Jiji Yang  ¹, Qi Pan  ², Enhui Chen  ³, Ning Zhang  ⁴, Siteng Chen  ⁵, Xiang Wang  ⁶ （Affiliations ¹ Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Pathology, Dongtai People's Hospital, Dongtai, Jiangsu, China. ⁴ Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zn12235@rjh.com.cn. ⁵ Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. siteng@sjtu.edu.cn. ⁶ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xiang.wang1@shgh.cn.）

出处： Journal of translational medicine 2024

关键词： Deep learning;Lymph node metastasis;Prognosis;Renal cell carcinoma;Whole slide images.

摘要： Background: Metastasis renal cell carcinoma (RCC) patients have extremely high mortality rate. A predictive model for RCC micrometastasis based on pat ...

作者： Yan Ma ^{#  1   2}, Ying Zhang ^{#  2}, Hui-Ying Zhang  ^{1   2}, Ya Zhao  ³, Xiu-Miao Li  ², Yi-Fei Jiang  ², Mu-Di Yao  ⁴, Qin Jiang  ^{5   6}, Biao Yan  ⁷ （Affiliations ¹ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. ² The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁴ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. mudiyao@163.com. ⁵ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. jiangqin710@126.com. ⁶ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. jiangqin710@126.com. ⁷ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. yanbiao@sjtu.edu.cn.）

出处： Journal of translational medicine 2024

关键词： Anti-angiogenic therapy;Exosomal formulation;Ocular vascular disease;Transfer RNA-derived fragment.

摘要： Background: Intravitreal injections of angiogenesis inhibitors have proved efficacious in the majority of patients with ocular angiogenesis. However, ...