作者： Kun Chen  ¹, Xin Zhu  ², Ruiqin Sun  ³, Lingzhou Zhao  ⁴, Junwei Zhao  ⁵, Xiangxiang Wu  ⁶, Can Wang  ⁷, Huahui Zeng  ⁸ （Affiliations ¹ Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China. ² Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China. ³ Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China. ⁴ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁵ Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China. ⁶ Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China. Electronic address: wuxx-415@126.com. ⁷ Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China. Electronic address: wangjiucan@163.com. ⁸ Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China; Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao, Henan University of Chinese Medicine, Zhengzhou 450046, China. Electronic address: hhzeng@hactcm.edu.cn.）

出处： International journal of biological macromolecules 2024

关键词： Aggregates;Breast cancer;Chitosan;Heparin;Oleanolic acid.

摘要： Oleanolic acid is an active ingredient from natural products with anti-breast cancer activity. However, the poor solubility in water and low bioavaila ...

作者： Yun-Qing Luo ^{#  1}, Zi-Song Xu ^{#  2}, Jin-Yu Hu  ³, Qian-Min Ge  ³, Jie Zou  ³, Hong Wei  ³, Xian-Mei Zhou  ⁴, Xuan Liao  ⁴, Qian Ling  ³, Liang-Qi He  ³, Cheng Chen  ³, Xiao-Yu Wang  ³, Yan-Mei Zeng  ⁵, Yi Shao  ^{6   7   8   9   10} （Affiliations ¹ Department of Ophthalmology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China. ² Huankui Academy, Nanchang University, Nanchang, 330006, Jiangxi, China. ³ Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China. ⁴ Ophthalmology Department of Affiliated Hospital, Medical School of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, 637000, Sichuan, China. ⁵ Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China. 1421204590@qq.com. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. freebee99@163.com. ⁷ National Clinical Research Center for Eye Diseases, Shanghai, 200080, China. freebee99@163.com. ⁸ Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, 200080, China. freebee99@163.com. ⁹ Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, 200080, China. freebee99@163.com. ¹⁰ Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. freebee99@163.com.）

出处： Scientific reports 2024

关键词： Microvascular density;Optical coherence tomography angiography;Pancreatitis.

摘要： Acute pancreatitis, a common exocrine inflammatory disease affecting the pancreas, is characterized by intense abdominal pain and multiple organ dysfu ...

作者： Bing Zhou  ¹, Yunchen Luo  ², Hanqi Bi  ³, Ni Zhang  ⁴, Mingyue Ma  ¹, Zhixia Dong  ³, Nana Ji  ³, Shuo Zhang  ³, Xiaoye Wang  ⁵, Yuejun Liu  ⁶, Xiaozhen Guo  ⁷, Wei Wei  ⁸, Cen Xie  ⁷, Ling Wu  ⁹, Xinjian Wan  ³, Ming-Hua Zheng  ⁴, Bing Zhao  ¹⁰, Yao Li  ¹¹, Cheng Hu  ¹², Yan Lu  ¹³ （Affiliations ¹ Institute of Metabolism and Regenerative Medicine, Digestive Endoscopic Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Endocrinology and Metabolism, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China. ³ Institute of Metabolism and Regenerative Medicine, Digestive Endoscopic Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ MAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. ⁵ State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China. ⁶ Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China. ⁷ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. ⁸ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. ⁹ Department of Assisted Reproduction, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁰ State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China. Electronic address: bingzhao@fudan.edu.cn. ¹¹ Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yao.li@shsmu.edu.cn. ¹² Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Institute for Metabolic Disease, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai, China. Electronic address: alfredhc@sjtu.edu.cn. ¹³ Institute of Metabolism and Regenerative Medicine, Digestive Endoscopic Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: luyan5011@shsmu.edu.cn.）

出处： Cell metabolism 2024

关键词： N6-methyladenosine methylation;deubiquitination;histone propionylation;nonalcoholic fatty liver disease;nonalcoholic steatohepatitis.

摘要： Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation nonalcoholic steatohepatitis (NASH), is a global public health chall ...

作者： Zihui Tang^1,21;Yu Cai Xu^3,22;Suyuan Wang^4,23;Jian Huang⁵4;Jun Liu¹5;Min Ding⁶6;Yang Sun⁷7;Ning Li¹8;Hengyu Li⁸CA9;Yan Lin⁶CA10;Chenjie Qin^1,5,9CA11 （¹Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;²Zihui Tang, Yucai Xu and Suyuan Wang contributed equally to this article.;³Department of Oncology, Pinghu Second People's Hospital, Zhapu Town, Jiaxing City, Zhejiang Province, China;⁴National Key Laboratory of Immunity and Inflammation, Naval Military Medical University, 800 Xiangyin Road, Shanghai 200433, China;⁵Department of Interventional radiology，Eastern Hepatobiliary Surgery Institute, the Naval Medical University, Shanghai 200438, China;⁶Department of Interventional Oncology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China;⁷Department of Pediatric Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;⁸Department of Breast and Thyroid Surgery, Changhai Hospital, Naval Military Medical University, 168 Changhai Road, Shanghai 200433, China;⁹Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China）

出处： Colloids and Surfaces B: Biointerfaces 2024

摘要： The hypoxic microenvironment within the tumor microenvironment of breast cancer imposes a challenge in overcoming chemotherapy resistance. In this inv ...

作者： Haixia Zhang  ¹, Lina Huang  ², Yiqing Guo  ³ （Affiliations ¹ Nursing Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ² Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650, New Songjiang Road, Shanghai, 201620, China. lina.huang@shgh.cn. ³ Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650, New Songjiang Road, Shanghai, 201620, China. yiqing.guo@shgh.cn.）

出处： Nutrition journal 2024

关键词： Antioxidant;Asthma;Inflammatory;Mortality;NHANES.

摘要： Background: The occurrence and progression of asthma can be influenced by the components in food. Our study aims to determine whether dietary antioxid ...

作者： Xiao-Xu Huang  ^{1   2   3   4}, Yi-Min Wang  ⁵, Min-Yue Xie  ⁶, Yi-Qing Sun  ⁷, Xiao-Huan Zhao  ^{1   2   3   4}, Yu-Hong Chen  ^{1   2   3   4}, Jie-Qiong Chen  ^{1   2   3   4}, Si-Yang Han  ^{1   2   3   4}, Min-Wen Zhou  ^{1   2   3   4}, Xiao-Dong Sun  ^{1   2   3   4} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ² National Clinical Research Center for Eye Disease, Shanghai 200080, China. ³ Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China. ⁴ Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China. ⁵ Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai 200030, China. ⁶ Beijing Tongren Hospital, Capital Medical University, Beijing 100054, China. ⁷ Eberly College of Science, Penn State University, University Park 16802-1503, United States.）

出处： International journal of ophthalmology 2024

关键词： Leber congenital amaurosis;VOSviewer;bibliometrics;gene therapy;hotpots.

摘要： Aim: To analyze the changes in scientific output relating to Leber congenital amaurosis (LCA) and forecast the study trends in this field. Methods: Al ...

作者： Yufei Chen  ¹, Yuan Zhou  ², Lihao Zhang  ¹, Yue Cao  ¹, Sunlong Li  ¹, Weipeng Lu  ¹, Zheng Mao  ¹, Zhiwei Jiang  ¹, Ying Wang  ¹, Cihui Liu  ¹, Qian Dong  ^{3   4   5} （Affiliations ¹ Center for Future Optoelectronic Functional Materials, School of Computer and Electronic Information/School of Artificial Intelligence, Nanjing Normal University, Nanjing 210023, China. cihui@njnu.edu.cn. ² Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, 650 Xinsongjiang Rd, Shanghai 201620, China. ³ Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. dongqian95fy@126.com. ⁴ Shanghai Key Laboratory of Gynecologic Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. ⁵ State Key Laboratory of Systems Medicine for Cancer, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.）

出处： Journal of materials chemistry. B 2024

摘要： The pursuit of flexible, sensitive, and cost-effective pressure sensors plays a pivotal role in medical diagnostics, particularly in the domain of cer ...

作者： Una Clancy  ¹, Carmen Arteaga-Reyes  ¹, Daniela Jaime Garcia  ¹, Will Hewins  ¹, Rachel Locherty  ¹, Maria Del C Valdés Hernández  ¹, Stewart J Wiseman  ¹, Michael S Stringer  ¹, Michael Thrippleton  ¹, Francesca M Chappell  ¹, Angela C C Jochems  ¹, Xiaodi Liu  ¹, Yajun Cheng  ¹, Junfang Zhang  ¹, Salvatore Rudilosso  ¹, Agniete Kampaite  ¹, Olivia K L Hamilton  ¹, Rosalind Brown  ¹, Mark E Bastin  ¹, Susana Muñoz Maniega  ¹, Iona Hamilton  ¹, Dominic Job  ¹, Fergus N Doubal  ¹, Joanna M Wardlaw  ¹ （Affiliation ¹ From the Row Fogo Centre for Research into Ageing and the Brain, Centre for Clinical Brain Sciences, and UK Dementia Research Institute (U.C., C.A.-R., D.J.G., W.H., R.L., M.D.C.V.H., S.J.W., M.S.S., M.T., F.M.C., A.C.C.J., A.K., O.K.L.H., R.B., M.E.B., S.M.M., I.H., D.J., F.N.D., J.M.W.), University of Edinburgh; Division of Neurology (X.L.), Department of Medicine, The University of Hong Kong; Department of Neurology (Y.C.), West China Hospital, Sichuan University, Chengdu, China; Department of Neurology (J.Z.), Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China; Comprehensive Stroke Center (S.R.), Department of Neuroscience, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute, Spain; and MRC/CSO Social and Public Health Sciences Unit (O.K.L.H.), School of Health and Wellbeing, University of Glasgow, United Kingdom.）

出处： Neurology 2024

摘要： Background and objectives: Factors associated with cerebral small vessel disease (SVD) progression, including incident infarcts, are unclear. We aimed ...

作者： Liming Lin  ^{1   2}, Jingjing Tao  ², Ying Meng  ², Yichao Gan  ³, Xin He  ⁴, Shu Li  ⁵, Jiawei Zhang  ¹, Feiqiong Gao  ¹, Dijia Xin  ¹, Luyao Wang  ¹, Yili Fan  ¹, Boxiao Chen  ¹, Zhimin Lu  ⁶, Yang Xu  ⁷ （Affiliations ¹ Department of Hematology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. ² Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital and Institute of Translational Medicine, Cancer Center, Zhejiang University School of Medicine, Hangzhou 310029, China. ³ Institute of Genetics, Zhejiang University, Hangzhou 310058, China. ⁴ Division of Hematopoietic Stem Cell & Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA. ⁵ Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. ⁶ Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital and Institute of Translational Medicine, Cancer Center, Zhejiang University School of Medicine, Hangzhou 310029, China. zhiminlu@zju.edu.cn. ⁷ Department of Hematology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. zhiminlu@zju.edu.cn, yxu@zju.edu.cn.）

出处： Journal of Zhejiang University. Science. B 2024

关键词： Acute myeloid leukemia (AML);Chemotherapy;Genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) library;Phosphatase and tensin homologous (PTEN);Rapamycin.

摘要： Although significant progress has been made in the development of novel targeted drugs for the treatment of acute myeloid leukemia (AML) in recent yea ...

作者： Jianyong Wei ^{#  1}, Xinyu Song ^{#  1}, Xiaoer Wei  ¹, Zhiwen Yang  ¹, Lisong Dai  ¹, Mengfei Wang  ¹, Zheng Sun  ¹, Yidong Jin  ¹, Chune Ma  ¹, Chunhong Hu  ¹, Xueqian Xie  ¹, Zhenghan Yang  ¹, Yonggao Zhang  ¹, Fajin Lv  ¹, Jie Lu  ¹, Yueqi Zhu  ¹, Yuehua Li  ¹ （Affiliation ¹ From the Clinical Research Center (J.W.) and Institute of Diagnostic and Interventional Radiology, Department of Radiology (X.S., X.W., L.D., Z.S., Y. Zhu, Y.L.), Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yi Shan Rd, Shanghai 200233, China; School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China (J.W., M.W., Y.J.); Shukun (Beijing) Network Technology, Beijing, China (Zhiwen Yang, C.M.); Department of Radiology, The First Affiliated Hospital of Soochow University, Jiangsu, China (C.H.); Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (X.X.); Department of Cardiology, Beijing Friendship Hospital of Capital Medical University, Beijing, China (Zhenghan Yang); Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China (Y. Zhang); Department of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (F.L.); and Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China (J.L.).）

出处： Radiology 2024

摘要： Background Deep learning (DL) could improve the labor-intensive, challenging processes of diagnosing cerebral aneurysms but requires large multicenter ...