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作者: Zhenguo Zi1,2;Shujuan Du3,2;Liming Zhang4,2;Yuebo Wang1;Ling Ding3;Chongqi Zhang1;Huanyu Wang1;Jan Pawlicki5;Yuan Cai6;Yazhou Yao7;Feng Zhou8;Yin Tong9;James L. Riley5;Qiliang Cai3CA1;Xiaojing Ma10CA2;Fang Wei1CA31Sheng Yushou Center of Cell Biology and Immunology, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;2contributed equally to this study;3MOE & NHC&CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai 200032, China;4Department of Medical Laboratory, Jiangxi Cancer Hospital, Nanchang 330029, China;5Center for Cellular Immunotherapy, Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;6Department of Pathology, Baoji Central Hospital, Baoji 721008, China;7Department of Hematology, Baoji Central Hospital, Baoji 721008, China;8Department of neurosurgery, Baoji Central Hospital, Baoji 721008, China;9Division of Hematology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China;10Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York)

出处: Blood Advances 2023

关键词: Golgi membrane protein 1 (GOLM1);anaplastic large cell lymphoma (ALCL);anaplastic lymphoma kinase (ALK) ALCL;apoptosis;B-cell lymphoma-extra-large protein (BCL-XL)

摘要: Golgi membrane protein 1 (GOLM1) is aberrantly expressed in many types of solid tumors and contributes to cancer development; however, its role in hem ...

作者: Lin Jin;Mengjiao Zhang;Lei Sha;Mengmeng Cao;Lanyue Tong;Qingqing Chen;Cuiqin Shen;Lianfang Du;Liping Liu;Zhaojun Li (Department of Ultrasound, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200052, China Department of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China Department of Medical Imaging, Weifang Medical University, Weifang, 261053, Shandong, China Department of Ultrasound, Shanghai General Hospital Jiading Branch, Shanghai Jiaotong University School of Medicine, Shanghai, 201803, China Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 100 Haining Road, Hongkou District, Shanghai, 200080, China)

出处: BMC Cardiovascular Disorders 2023

关键词: Arterial stiffness;Cardiovascular disease;Arterial pressure volume index;Risk assessment

摘要: Background and objective The new non-invasive arterial stiffness indices, arterial pressure volume index (API) is explored as a novel marker of residu ...

作者: Xuyu Gu1;Lubing Cai2;Zhiwen Luo3;Luze Shi2;Zhen Peng2;Yaying Sun3;Jiwu Chen21School of Medicine, Southeast University, Nanjing, China;2Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China;3Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China)

出处: Frontiers in Immunology 2023

关键词: lung adenocarcinoma;muscle failure index;ScRNA-seq;prognosis;immunotherapy

摘要: BackgroundIt was previously reported that the production of exerkines is positively associated with the beneficial effects of exercise in lung adenoca ...

作者: Leheng Liu1;Leheng Liu2;Zhixia Dong3;Jinnian Cheng4;Xiongzhu Bu5;Kaili Qiu5;Chuan Yang5;Jing Wang6;Wenlu Niu1;Xiaowan Wu1;Jingxian Xu1;Jingxian Xu2;Tiancheng Mao1;Tiancheng Mao2;Lungen Lu1;Lungen Lu2;Xinjian Wan3;Hui Zhou1;Hui Zhou21Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China;3Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China;4Department of Gastroenterology, Shanghai Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;5School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing, China;6Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Frontiers in Oncology 2023

关键词: deep learning;suspected superficial lesions;magnifying endoscopy with narrow band imaging (ME-NBI);gastric neoplastic lesions;convolutional neural network (CNN)

摘要: BackgroundEndoscopically visible gastric neoplastic lesions (GNLs), including early gastric cancer and intraepithelial neoplasia, should be accurately ...

作者: Nan Li1;Chenxing Huang2;Jie Zhang3;Junyue Zhang1;Jia Huang2;Shangshang Li1;Xue Xia1;Ziyu Wu1;Chenglong Chen1;Shuwan Tang1;Xiangyu Xiao1;Hui Gong2;Yuxiang Dai2CA1;Chun Mao1CA2;Mimi Wan1CA31National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China;2Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine, Shanghai 200433, China;3Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China)

出处: ACS Nano 2023

关键词: ischemia-reperfusion injury;nanomotors;nitric oxide;hydrogen sulfide;targeted delivery

摘要: Recombinant granulocyte colony-stimulating factor (G-CSF), with a direct repair effect on injured cardiomyocytes against myocardial infarction ischemi ...

作者: Zhengzhe Han1;Lili Deng2;Shiyan Chen2CA;Huaping Wang2CA;Yinjun Huang3CA1Department of Orthopedic Surgery, and Shanghai Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital , 600 Yishan Road, Shanghai 200233, P.R. China;2State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201620, P.R. China;3Department of Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, 201600, P.R. China)

出处: Burns & Trauma 2023

关键词: Hydrogel;Mechanical properties;Biocompatibility;Angiogenic effects;Wound healing

摘要: Background Wound healing is a process that requires angiogenesis and antibacterial activities and it remains a challenge for both experimental and cl ...

作者: Xu Quan1;Ying Xin2;He-Ling Wang3;Yingjie Sun4;Chanchan Chen5;Jiangying Zhang41Department of Stomatology, Shanghai General Hospital, Shanghai, China;2Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, China;3Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway;4Xiangya School of Stomatology, Central South University, Changsha, Hunan, China;5Department of Stomatology, Shenzhen Children’s Hospital, Shenzhen, Guangdong, China)

出处: PeerJ 2023

关键词: Sirtuin;Metabolic regulation;Oral cancer

摘要: Sirtuins (SIRTs 1-7) are a group of histone deacetylase enzymes with a wide range of enzyme activities that target a range of cellular proteins in the ...

作者: Haowei Bai1;Yanwei Sha2;Yueqiu Tan3;Peng Li1;Yuxiang Zhang1;Junwei Xu1;Shuai Xu1;Zhiyong Ji1;Xiaobo Wang1;Wei Chen1;Jianxiong Zhang1;Chencheng Yao1;Zheng Li1;Erlei Zhi11Department of Andrology, Center for Men’s Health, Department of ART, Institute of Urologic Medical Center, Shanghai General Hospital, Shanghai Key Lab of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2Department of Andrology, Women and Children’s Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China;3Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, China)

出处: Frontiers in Endocrinology 2023

关键词: TAF7L;hemizygous variant;oligoasthenoteratozoospermia;ICSI;male infertility

摘要: IntroductionOligoasthenoteratozoospermia (OAT) is a major cause of infertility in males. Only a few pathogenic genes of OAT have been clearly identifi ...

作者: Nengneng Li1;Nengneng Li2;Shiquan Xu1;Shiquan Xu2;Shuaishuai Zhang1;Shuaishuai Zhang2;Qiang Zhu1;Qiang Zhu2;Xiaole Meng1;Xiaole Meng2;Wenbin An1;Wenbin An2;Baoqing Fu1;Baoqing Fu2;Baoqing Fu3;Mengya Zhong4;Yan Yang2;Zeyang Lin5;Xueni Liu6;Junjie Xia2;Jie Wang1;Jie Wang2;Tingting You1;Tingting You2;Changxiu Yan2;Huamei Tang7;Guohong Zhuang2;Zhihai Peng1;Zhihai Peng2;Zhihai Peng81Department of Organ Transplantation, Xiang’an Hospital, Xiamen University, Xiamen, Fujian, China;2Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, Organ Transplantation Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China;3Department of Laboratory Medicine, Xiang’an Hospital, Xiamen University, Xiamen, Fujian, China;4Cancer Research Center, School of Medicine, Xiamen University, Xiamen, Fujian, China;5Department of Pathology, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China;6Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;7Department of Pathology, Xiang’an Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China;8Organ Transplantation Clinical Medical Center of Xiamen University, Xiamen, Fujian, China)

出处: Frontiers in Immunology 2023

关键词: inflammatory bowel disease;intestinal microbiota;Musashi2;group 3 innate lymphoid cells;Lactobacillaceae

摘要: BackgroundThe etiology and pathogenesis of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), are generally ...

作者: Shengli Li12;Li Yuan134;Zhi-Yuan Xu134;Jing-Li Xu5;Gui-Ping Chen6;Xiaoqing Guan1;Guang-Zhao Pan1;Can Hu5;Jinyun Dong1;Yi-An Du134;Li-Tao Yang134;Mao-Wei Ni1;Rui-Bin Jiang1;Xiu Zhu1;Hang Lv7;Han-Dong Xu5;Sheng-Jie Zhang1;Jiang-Jiang Qin134CA1;Xiang-Dong Cheng134CA21Department of Gastric Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, 310022, China;2Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China;3Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China;4Zhejiang Key Lab of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer, Zhejiang Cancer Hospital, Hangzhou, 310022, China;5First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China;6Department of Gastrointestinal Surgery, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China;7Biological Sample Bank, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China)

出处: Nature Communications 2023

摘要: The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been rapidly increasing in recent decades, but its molecular alterations and ...

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