作者： Xiao-Yan Song  ¹, Cun-Xiu Fan  ², Atta-Ur-Rahman Frs  ³, Muhammad Iqbal Choudhary  ³, Xiao-Ping Wang  ² （Affiliations ¹ Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. ² Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. ³ H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.）

出处： Current neuropharmacology 2024

关键词： Alzheimer’s disease;Cell therapy;Parkinson’s disease;Wilson’s disease;amyotrophic lateral sclerosis;stem cells;stroke;traumatic brain injury..

摘要： The human central nervous system (CNS) has a limited capacity for regeneration and repair, as many other organs do. Partly as a result, neurological d ...

作者： Ting Shen  ^{1   2   3}, Samran Sheriff  ², Yuyi You  ^{2   3}, Jiyang Jiang  ⁴, Angela Schulz  ², Heather Francis  ^{2   5}, Mehdi Mirzaei  ², Danit Saks  ², Viswanthram Palanivel  ², Devaraj Basavarajappa  ², Nitin Chitranshi  ², Veer Gupta  ⁶, Wei Wen  ⁴, Perminder S Sachdev  ^{4   7}, Huixun Jia  ¹, Xiaodong Sun  ¹, Stuart L Graham  ^{2   3}, Vivek K Gupta  ² （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China. ² Macquarie Medical School, Macquarie University, Sydney, NSW 2109, Australia. ³ Save Sight Institute, The University of Sydney, Sydney, NSW 2000, Australia. ⁴ Centre for Healthy Brain Ageing, School of Clinical Medicine, University of New South Wales, Sydney, NSW 2052, Australia. ⁵ Neurology Department, Royal North Shore Hospital, St Leonards NSW 2065, Australia. ⁶ Faculty of Health, Deakin University, VIC 3125, Australia. ⁷ Neuropsychiatric Institute, Prince of Wales Hospital, Randwick NSW 2031, Australia.）

出处： Aging and disease 2024

摘要： Aging is associated with progressive brain atrophy and declines in learning and memory, often attributed to hippocampal or cortical deterioration. The ...

作者： Zhi-Chao Xi ^{#  1   2}, Han-Gui Ren ^{#  1   2}, Lin Ai  ³, Yuan Wang  ³, Meng-Fan Liu  ^{1   2}, Yu-Fei Qiu  ³, Ji-Ling Feng  ⁴, Wang Fu  ³, Qian-Qian Bi  ³, Feng Wang  ⁵, Hong-Xi Xu  ^{6   7} （Affiliations ¹ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. ² Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China. ³ Department of Neurology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. ⁴ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ⁵ Department of Neurology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China. wangfengshutcm@163.com. ⁶ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. xuhongxi88@gmail.com. ⁷ Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, 201203, China. xuhongxi88@gmail.com.）

出处： Acta pharmacologica Sinica 2024

关键词： autophagy;cerebral ischaemia/reperfusion injury;ginsenoside Rg1;ischaemic stroke;lysosome function;mTOR.

摘要： Reperfusion injury, which is distinct from ischaemic injury, occurs when blood flow is restored in previously ischaemic brain tissue, further compromi ...

作者： Min Zhang¹;Lixia Xia¹;Wenbei Peng²;Guogang Xie³;Fei Li¹;Chao Zhang¹;Madiha Zahra Syeda¹;Yue Hu¹;Fen Lan¹;Fugui Yan¹;Zhangchu Jin¹;Xufei Du¹;Yinling Han¹;Baihui Lv¹;Yuejue Wang¹;Miao Li¹;Xia Fei¹;Yun Zhao¹;Kaijun Chen¹;Yan Chen⁴;Wen Li¹;Zhihua Chen¹;Qiong Zhou²CA1;Min Zhang³CA2;Songmin Ying¹⁴⁵CA3;null;Huahao Shen¹⁶CA4 （¹Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Zhejiang Province, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China;²Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China;³Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;⁴International Institutes of Medicine, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, 322000, China;⁵Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, 310058, China;⁶State Key Lab for Respiratory Diseases, National Clinical Research Centre for Respiratory Disease, Guangzhou, 510120, Guangdong, China）

出处： npj Precision Oncology 2024

摘要： Malignant pleural effusion (MPE) is a common occurrence in advanced cancer and is often linked with a poor prognosis. Eosinophils were reported to inv ...

作者： Jing Li¹;Jing Li²;Qian Ma³;Mudi Yao⁴;Mudi Yao⁵;Qin Jiang⁴;Zhenhua Wang²;Biao Yan¹;Biao Yan⁵ （¹Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China;²College of Information Science, Shanghai Ocean University, Shanghai, China;³Department of Ophthalmology, General Hospital of Ningxia Medical University, Ningxia, China;⁴Department of Ophthalmology and Optometry, The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China;⁵Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Frontiers in Medicine 2024

关键词： diabetic retinopathy;segmentation model;microaneurysms;fluorescein fundus angiography;computer-aided diagnosis

摘要： IntroductionMicroaneurysms serve as early signs of diabetic retinopathy, and their accurate detection is critical for effective treatment. Due to thei ...

作者： Xinzi Zhang  ^{1   2   3   4}, Fang Zhang  ^{1   2   3   4}, Xun Xu  ^{1   2   3   4} （Affiliations ¹ National Clinical Research Center for Eye Diseases, Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Eye Institute of Shanghai Jiao Tong University School, Shanghai, China. ³ Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. ⁴ Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.）

出处： Clinical and translational medicine 2024

关键词： diabetic retinopathy;pathogenesis;single‐cell RNA sequencing.

摘要： Diabetic retinopathy (DR) is a leading cause of irreversible blindness in the working-age populations. Despite decades of research on the pathogenesis ...

作者： Xiaoxia Tang  ^{1   2}, Jin Wei  ², Shaohua Wu  ², Sufang Wu  ¹ （Affiliations ¹ Shanghai General Hospital of Nanjing Medical University, Shanghai, China. ² The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, China.）

出处： BJOG : an international journal of obstetrics and gynaecology 2024

关键词： fasting blood glucose;gestational diabetes mellitus;macrosomia;third trimester.

摘要： Objective: To investigate the positive rate of late-onset gestational diabetes mellitus (GDM) by additional fasting blood glucose (FBG) screening at 3 ...

作者： Chongmei Huang  ¹, Yannan Jia  ¹, Jun Yang  ¹, Yu Cai  ¹, Yin Tong  ¹, Huiying Qiu  ¹, Kun Zhou  ¹, Xinxin Xia  ¹, Ying Zhang  ¹, Chang Shen  ¹, Liping Wan  ¹, Xianmin Song  ¹ （Affiliation ¹ Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： British journal of haematology 2024

关键词： allogeneic peripheral blood stem cell transplantation (allo‐PBSCT);azacitidine;interferon‐α;pre‐emptive therapy.

摘要： This prospective clinical study aimed to evaluate the efficacy and safety of the pre-emptive treatment modality of azacitidine in combination with int ...

作者： Weixue Huo ^{#  1}, Mengwei He ^{#  1}, Zhaoxiang Zeng  ², Xianhao Bao  ¹, Ye Lu  ¹, Wen Tian  ¹, Jiaxuan Feng  ³, Rui Feng  ¹ （Affiliations ¹ Department of Vascular Surgery, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. ² Department of Vascular Surgery, Changhai Hospital, Navy Medical University, Shanghai, China. ³ Vascular Surgery Department, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.）

出处： Journal of medical Internet research 2024

关键词： COVID-19;ChatGPT;patient concern;patient satisfaction;physician-patient relationship.

摘要： Background: In the era of the internet, individuals have increasingly accustomed themselves to gathering necessary information and expressing their op ...

作者： Daonan Chen ^{#  1}, Kun Zhou ^{#  2}, Rui Tian  ¹, Ruilan Wang  ³, Zhigang Zhou  ³ （Affiliations ¹ Shanghai General Hospital, Department of Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Shanghai General Hospital, Department of Hematology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Shanghai General Hospital, Department of Critical Care Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China zhou_zhigang1980@163.com wangyusun@hotmail.com.）

出处： BMJ open 2024

关键词： adult intensive & critical care;infectious diseases;mortality.

摘要： Objectives: The objective of the study was to assess the clinical predictive value of the dynamics of absolute lymphocyte count (ALC) for 90-day all-c ...