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作者: Jinghan Song  1, Xiong Ye  2, Hui Xiao  1 (Affiliations 1 Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: xiaohui771210@163.com. 2 School of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, China.)

出处: Critical reviews in oncology/hematology 2025

关键词: Antineoplastic treatment;Cancer screening;Clinical application;Liquid biopsy;Metastasis;Recurrence.

摘要: In recent years, liquid biopsy has gained prominence as an emerging biomarker in cancer research, providing critical insights into tumor biology and m ...

作者: Min Zhang  1   2, Jiali Wu  1   2, Yimin Wang  3, Yidong Wu  1   2, Xiaoling Wan  1   2, Mei Jiang  1   2, Qiyu Bo  1   2, Jieqiong Chen  1   2, Xiaodong Sun  1   2   4   5 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. 2 National Clinical Research Center for Ophthalmic Diseases, Shanghai, China. 3 Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China. 4 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. 5 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.)

出处: Aging cell 2025

关键词: EndMT;VASH1;circSIRT2;miR‐542‐3p;subretinal fibrosis.

摘要: Neovascular age-related macular degeneration (nAMD), characterized by choroidal neovascularization (CNV), is one of the leading causes of severe visua ...

作者: Qinqin Cai1,2;Qiao Zhao1,2;Qingxia Yang1;Min Zhu1;Fufen Meng1CA1;Jihong Jiang3CA21Department of Anesthesiology, Xinjiang Medical University Affiliated Cancer Hospital, Urumqi, Xinjiang, China;2These authors contributed equally to this work.;3Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Experimental Cell Research 2025

关键词: Ku70;Ku86;P300;Diabetic kidney injury;Glomerular endothelial cell

摘要: Endothelial inflammation caused by hyperglycemia contributes to cardiovascular complications in patients with diabetes. Diabetic kidney injury (DKI) i ...

作者: Huibiao Deng  1, Peng Wang  2, Minxing Liu  3 (Affiliations 1 Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. 2 Department of Emergency, The First Affiliated Hospital of Soochow University, No.899, Pinghai Road, Gusu District, Suzhou City, Jiangsu Province, 215031, China. 3 Department of Emergency, The First Affiliated Hospital of Soochow University, No.899, Pinghai Road, Gusu District, Suzhou City, Jiangsu Province, 215031, China. minxingliu0921@163.com.)

出处: Journal of cardiothoracic surgery 2025

关键词: Intensive care unit;Prognostic value;Pulmonary hypertension.

摘要: Background: The impact of pulmonary hypertension (PH) on critically ill patients has not been fully understood. Our objective was to explore the possi ...

作者: Meng-Qi Zhao  1   2   3, Miao-Yan Fan  2   3, Meng-Yan Cui  2   3, Su-Min Chen  1, Jing-Jing Wang  3, Ying-Ying Lu  4   5, Qiao-Li Jiang  6 (Affiliations 1 Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai, 201803, China. 2 Department of Gastroenterology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 201620, China. 3 Shanghai Key Laboratory of Pancreatic Diseases, Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. 4 Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai, 201803, China. le_voyageur@sjtu.edu.cn. 5 Department of Gastroenterology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 201620, China. le_voyageur@sjtu.edu.cn. 6 Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai, 201803, China. mqzh0547@sjtu.edu.cn.)

出处: Gut pathogens 2025

关键词: Acute pancreatitis;Candida;Fungal diversity;Fungi;Gut microbiota.

摘要: Objective: The gut is involved in the development of acute pancreatitis (AP). Increased focus is being given to the role of gut microbiota in the path ...

作者: Junying Wei  1, Heshan Cao  2, Mingling Peng  1, Yinzhou Zhang  3, Sibei Li  4, Wuhua Ma  5, Yuhui Li  5 (Affiliations 1 First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. 2 Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. 3 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. 4 Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. 5 Department of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.)

出处: PloS one 2025

摘要: Background: Ventilator-associated pneumonia (VAP) is a common nosocomial infection in ICU, significantly associated with poor outcomes. However, there ...

作者: Ruqiang Yuan #  1, Mingjing Gao #  2   3, Hu Xu #  4, Qing Liang  1, Lei Qian  1, Yali Wang  1, Houli Zhang  5, Erjiao Qiang  6, Weijing Yun  7 (Affiliations 1 Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China. 2 Department of Pharmacy, Dalian Port Hospital, Dalian, 116001, China. 3 College of Pharmacy, Dalian Medical University, Dalian, 116044, China. 4 Wuhu Hospital and Health Science Center, East China Normal University, Shanghai, 200241, China. 5 College of Pharmacy, Dalian Medical University, Dalian, 116044, China. houlizh@163.com. 6 Department of Pathology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. qiangerjiao@126.com. 7 Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China. yunweijing@dmu.edu.cn.)

出处: BMC cardiovascular disorders 2025

关键词: Calcium influx;Alantolactone;Hypertension;Voltage-gated Calcium Channels.

摘要: Background: The dried root of Inula helenium L., known as Inulae Radix in Mongolian medicine, is a widely used heat-clearing plant drug within the Ast ...

作者: Ying Zhang #  1   2   3, Yan Ma #  1   2, Yu-Ke Ji #  1   2, Yi-Fei Jiang  1   2, Duo Li  1   2, Wan Mu  4, Mu-Di Yao  5, Jin Yao  6   7, Biao Yan  8 (Affiliations 1 The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. 2 The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. 3 Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. 4 Eye Institute, Department of Ophthalmology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200030, China. 5 Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. mudiyao@163.com. 6 The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. jinyao1972@126.com. 7 The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. jinyao1972@126.com. 8 Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. yanbiao@sjtu.edu.cn.)

出处: Cell communication and signaling : CCS 2025

关键词: Ischemic/reperfusion injury;Müller cells;Reactive gliosis;Retinal ganglion cells;tsRNA.

摘要: Ischemic retinopathies are the major causes of blindness, yet effective early-stage treatments remain limited due to an incomplete understanding of th ...

作者: Jiandong Zhou  1, Yunshan Guo  1, Xuan Liu  1, Weijie Yuan  1 (Affiliation 1 Department of Nephrology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.)

出处: Adipocyte 2025

关键词: Secretory proteins;adipose tissue;bioinformatics;epigenetics;metabolic syndrome.

摘要: The objective of this study was to identify key secretory protein-encoding differentially expressed genes (SP-DEGs) in adipose tissue in female metabo ...

作者: Wei Chen  1, Yuanjun Tang  2, Yachen Si  1, Boxiang Tu  3, Fuchuan Xiao  4, Xiaolu Bian  1, Ying Xu  1, Yingyi Qin  3 (Affiliations 1 Department of Nephrology, Shanghai Changhai Hospital, Shanghai 200433, China. 2 Department of Clinical Pharmacy, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200240, China. 3 Department of Military Health Statistics, Naval Medical University, Shanghai 200433, China. 4 Navy No. 929 Hospital, Shanghai 200433, China.)

出处: Journal of translational internal medicine 2025

关键词: all-cause mortality;chronic kidney disease;life’s essential 8.

摘要: Background and objectives: The association between chronic kidney disease (CKD) and cardiovascular disease has been previously evaluated. This study a ...

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