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作者: Hong Yao  1, Wanqun Xie  1, Yuting Dai  2, Yanting Liu  1, Weiting Gu  1, Jianfeng Li  2, Liang Wu  2, Jing Xie  3, Weiwei Rui  3, Bohan Ren  4, Li Xue  1, Yijun Cheng  1, Shaojian Lin  1, Changsheng Li  1, Hao Tang  1, Yu Wang  5, Meiqing Lou  6, Xiaobiao Zhang  7, Ronggui Hu  8, Hanbing Shang  1, Jinyan Huang  2, Zhe Bao Wu  1   4 (Affiliations 1 Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 5 Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 7 Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China. 8 State Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.)

出处: Neuro-oncology 2022 Pnoac053

关键词: Cushing\'s disease;PitNETs;TPIT;TRIM65;ubiquitination.

摘要: Background: Pituitary neuroendocrine tumors (PitNETs) are common intracranial tumors that are classified into seven histological subtypes, including l ...

作者: Fariha Kanwal  1, Mingming Ma  2, Muhammad Fayyaz Ur Rehman  3, Fahim-Ullah Khan  4, Shai E Elizur  5, Aima Iram Batool  6, Chi Chiu Wang  7, Tahira Tabassum  8, Changrui Lu  9, Yao Wang  10 (Affiliations 1 School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Key Laboratory of Ocular Fundus Diseases, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 3 Institute of Chemistry, University of Sargodha, Sargodha, Pakistan. 4 Department of Biotechnology, University of Science and Technology, Bannu, Pakistan. 5 IVF Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. 6 Department of Zoology, University of Sargodha, Sargodha, Pakistan. 7 Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Shatin, Hong Kong, China. 8 Department of Pathology, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. 9 Department of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China. 10 Department of Assisted Reproduction, School of Medicine, Shanghai Ninth People\'s Hospital, Shanghai Jiao Tong University, Shanghai, China.)

出处: Frontiers in molecular biosciences 2022 Vol.8 P788279

关键词: aspirin;breast cancer;mesoporous silica;nanomedicine;nanoparticle.

摘要: Breast cancer affects more than 1 million women per year worldwide. Through this study, we developed a nanoparticle-based drug delivery system to targ ...

作者: Chun Yang #  1   2, Yuxiao Ma #  1   2, Li Xie  3, Xiang Wu  4, Jiyuan Hui  1   2, Jiyao Jiang  1   2, Guoyi Gao  5, Junfeng Feng  6   7 (Affiliations 1 Brain Injury Center, Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 2 Shanghai Institute of Head Trauma, Shanghai, China. 3 Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. gao3@sina.com. 6 Brain Injury Center, Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. fengjfmail@163.com. 7 Shanghai Institute of Head Trauma, Shanghai, China. fengjfmail@163.com.)

出处: Neurocritical care 2022

关键词: In-hospital mortality;Intensive care unit;Intracranial pressure monitoring;Length of stay;Traumatic brain injury.

摘要: Background: Although the current guidelines recommend the use of intracranial pressure (ICP) monitoring in patients with severe traumatic brain injury ...

作者: Jialing Zhang #  1   2, Li Cao #  3, Wenji Wang  1   2, Yu Huo  2   4, Yuanzheng Zheng  2   4, Fang Wu  5, Yonghao Gui  2   4 (Affiliations 1 Institute of Pediatrics, Children\'s Hospital of Fudan University, Shanghai, China. 2 NHC Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China. 3 Ultrasound Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. 4 Cardiovascular Center, Children\'s Hospital of Fudan University, Shanghai, China. 5 Department of Neonatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Journal of developmental origins of health and disease 2022 P1-9

关键词: Oxidative stress;antioxidants;cardiac dysfunction;prenatal overnutrition;ventricular remodeling.

摘要: Maternal overnutrition-induced fetal programming predisposes offspring to cardiovascular health issues throughout life. Understanding how these advers ...

作者: Zeyu Zhang  1, Yue Zhao  2, Yibo Liu  1, Xiaoyu Wang  1, Houshi Xu  3, Yuanjian Fang  1, Anke Zhang  1, Cameron Lenahan  4, Yujie Luo  1, Sheng Chen  1 (Affiliations 1 Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 2 Department of Stomatology, The Children\'s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Health, Hangzhou, China. 3 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Center for Neuroscience Research, Loma Linda University School of Medicine, Loma Linda, California, USA.)

出处: CNS neuroscience & therapeutics 2022

关键词: complication;functional outcome;hyperglycemia;neuroendocrine;stress;subarachnoid hemorrhage.

摘要: Background: Despite having an overall benign course, non-traumatic non-aneurysmal subarachnoid hemorrhage (naSAH) is still accompanied by a risk of cl ...

作者: Yiwen Zhu  1, Junjun Zhang  1, Chunlin Li  2, Guoying Deng  2, Junyan Li  1, Xijian Liu  3, Bo Wan  4, Ye Tian  1 (Affiliations 1 Department of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, Institute of Radiation Oncology, Soochow University, San Xiang Road No. 1055, Suzhou 215004, Jiangsu, China. 2 Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201620, China. 3 College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China. 4 Institute of Neuroscience, Soochow University, Renai Road No. 199, Suzhou 215123, Jiangsu, China.)

出处: ACS biomaterials science & engineering 2022

关键词: Se@SiO2 nanoparticles;hippocampus;radiation;reactive oxygen species.

摘要: Radiotherapy has been widely used to manage primary and metastatic brain tumors. However, hippocampal damage and subsequent cognitive dysfunction are ...

作者: Jingwen Zhou  1, Huanqiang Zhao  2   3, Han Yang  1, Chunyan He  1, Wen Shu  1, Zelin Cui  1, Qingzhong Liu  4 (Affiliations 1 Department of Clinical Laboratory, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 2 Obstetrics and Gynaecology Hospital, Fudan University, Shanghai, China. 3 The Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China. 4 Department of Clinical Laboratory, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.)

出处: Frontiers in cellular and infection microbiology 2022 Vol.12 P746746

关键词: SprC;Staphylococcus aureus;metabolomics;regulation role;small RNA;transcriptome.

摘要: Aim: Our previous proteomic analysis showed that small RNA SprC (one of the small pathogenicity island RNAs) of Staphylococcus aureus possesses the ab ...

作者: Zhencang Zhou  1   2, Pengqiang Wu  1, Fujue Wang  1, Huan Tao  1, Yingying Chen  1, Jie Gao  1   3, Dengke Chen  2, Yongqian Jia  1 (Affiliations 1 Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, Chengdu, Sichuan, China. 2 Department of Hematology, The Third Affiliated Hospital of Zunyi Medical University (The First People\'s Hospital of Zunyi ), Zunyi, Guizhou, China. 3 Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.)

出处: Medicine 2022 Vol.101 No.9 Pe28938

摘要: Rationale: Marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) has an indolent natural course and disseminates slow ...

作者: Mengdi Xia1;Fen Zhao2;Yongji Zhang2;Zhihuang Zheng3;Yun Zhou2CA1;Tong Liu2CA2 (1 Nanchong Key Laboratory of Basic Science & Clinical Research On Chronic Kidney Disease, Department of Nephrology, The Second Clinical Medical Institution of North Sichuan Medical College (Nanchong Central Hospital), Nanchong, China; 2 Shanxi Kidney Disease Institute, Department of Nephrology, Shanxi Provincial People’s Hospital, The Affiliated People’s Hospital of Shanxi Medical University, Taiyuan, China; 3 Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China)

出处: European Journal of Medical Research 2022 Vol.27 No.1

关键词: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV);ANCA-associated glomerulonephritis;Hub gene;CIBERSORT;Immune infiltration

摘要: Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of life-threatening systemic autoimmune diseases. The aim of th ...

作者: Ying Peng  1   2, Peihong Xu  3, Juan Shi  1   2, Yifei Zhang  1   2, Shujie Wang  1   2, Qidong Zheng  4, Yufan Wang  5, Tingyu Ke  6, Li Li  7, Dong Zhao  8, Yuancheng Dai  9, Qijuan Dong  10, Bangqun Ji  11, Fengmei Xu  12, Weiqiong Gu  1   2, Weiqing Wang  1   2 (Affiliations 1 Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Internal Medicine, The Second People\'s Hospital of Yuhuan, Yuhuan, China. 5 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Department of Endocrinology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China. 7 Department of Endocrinology, Ningbo First Hospital, Ningbo, China. 8 Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China. 9 Department of Internal Medicine of Traditional Chinese Medicine, Sheyang Diabetes Hospital, Yancheng, China. 10 Department of Endocrinology and Metabolism, People\'s Hospital of Zhengzhou Affiliated Henan University of Chinese Medicine, Zhengzhou, China. 11 Department of Endocrinology, Xingyi People\'s Hospital, Xinyi, China. 12 Department of Endocrinology and Metabolism, Hebi Coal (Group), Ltd, General Hospital, Hebi, China.)

出处: Journal of diabetes 2022

关键词: basal insulin;body mass index;glycemic hemoglobin;premixed insulin;type 2 diabetes.

摘要: Background: To investigate the different efficacies of glycemic control between basal and premixed insulin in participants with type 2 diabetes (T2DM) ...

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