作者： Yingzhao Liu ^{# 1}, Wanwan Shao ^{# 2}, Weiliang Miao ¹, Mei Li ³, Yaofa Lin ⁴ （Affiliations ¹ Department of Orthopaedics, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai, 201803, People's Republic of China. ² Department of Orthopaedics, Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai, 200001, People's Republic of China. ³ Nantong University Xinglin College Affiliated Hospital, 666 South Ring Road, Jiangsu, 224700, People's Republic of China. jhyy_limei@126.com. ⁴ Department of Orthopaedics, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai, 201803, People's Republic of China. lyflc106@163.com.）

出处： Journal of molecular histology 2026

关键词： Chronic inflammation;CircRNA;Ligament differentiation;ZIC1;miR-203a-3p.

摘要： Implant of mesenchymal stem cells (MSCs) is a promising therapy for the reconstruction of anterior cruciate ligament (ACL), but the chronic inflammati ...

作者： Xiang Xu ^{1 2}, Shizhen Qiu ^{3 4}, Zhitong Wang ^{1 2}, Dan Li ^{1 2}, Min Chen ¹, Yinying Chu ¹, Guangfei Li ¹, Yi Fang ¹, Changjiang Li ¹, Fang Shi ¹, Peijie He ¹, Haitao Wu ^{1 2}, Haopeng Wang ^{4 5}, Jian Chen ^{1 2} （Affiliations ¹ ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China. ² Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, Fudan University, Shanghai, China. ³ Department of Hematology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. ⁴ School of Life Science and Technology, ShanghaiTech University, Shanghai, China. ⁵ Changping Laboratory, Beijing, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026

关键词： CAR‐T;CSPG4;HNSCC;humanization;tonic signaling.

摘要： Major challenges of developing CAR‑T cell therapy for head and neck squamous cell carcinoma (HNSCC) include identifying a robust tumor antigen and a s ...

作者： Haikuo Li ¹ （Affiliation ¹ Precision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; State Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, China. Electronic address: haikuo.li@wustl.edu.）

出处： Kidney international 2026

关键词： cardiorenal syndrome;cardiovascular-kidney-metabolic syndrome;chronic kidney disease;proteogenomics;quantitative trait loci.

作者： Hang Gao ¹, Li Wang ², Zeze Fu ³, Yun Sun ⁴, Rong Wang ⁴, Quan Liu ⁵, Fei Gao ⁵, Jiyu Guan ⁵, Liang Zhu ⁶, Duoduo Zhang ⁷, Yicheng Zhao ⁸ （Affiliations ¹ Department of Bone and Joint Surgery, Orthopaedic Surgery Center, The First Hospital of Jilin University, Changchun, China. ² Chinese Medicine Guangdong Laboratory /State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Clinical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong, China. ³ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 200240, China. ⁴ Changchun University of Chinese Medicine, Changchun, China. ⁵ State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Jilin University, Changchun, China. ⁶ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 200240, China. Electronic address: zhuliangspine@hotmail.com. ⁷ Department of Thoracic Surgery, The First Hospital of Jilin University, Changchun, 130021, China. Electronic address: ddzhang@jlu.edu.cn. ⁸ Chinese Medicine Guangdong Laboratory /State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Clinical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong, China. Electronic address: yichengzhao@live.cn.）

出处： International journal of antimicrobial agents 2026

关键词： MRSA;Quercetin-3-O-glucuronide;caseinolytic peptidase P;pneumonia;sortase A.

摘要： The natural flavonoid quercetin-3-O-glucuronide (Q3G) has emerged as a potent antivirulence agent against methicillin-resistant Staphylococcus aureus ...

作者： Ran Sun ¹, Min Wang ², Xi Li ³, Yanke Zhang ⁴ （Affiliations ¹ Jining Medical University, Jining, 272000, China; Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, PR China. ² Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. ³ Jining Medical University, Jining, 272000, China. ⁴ Jining Medical University, Jining, 272000, China; Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, PR China; Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Electronic address: yankezhang@mail.jnmc.edu.cn.）

出处： Behavioural brain research 2026

关键词： Adeno-associated virus;Epilepsy;Kainic acid;Pentylenetetrazol;SIK2.

摘要： Salt-inducible kinase 2 (SIK2) is a serine/threonine kinase implicated in several neurological disorders; however, its role in epilepsy remains unclea ...

作者： Aurelie Chiche ^{# 1}, Lamia Djoual ^{# 1}, Elsa Charifou ^{# 1 2}, Shuoyang Wang ^{1 3}, Laurianne Temime ¹, Marielle Saclier ¹, Shaoxiang Wang ^{1 4}, Jeremy Chantrel ^{1 2}, Han Li ⁵ （Affiliations ¹ Cellular plasticity in age-related pathologies, Department of Developmental & Stem Cell Biology, CNRS UMR 3738, Université Paris Cité, Institut Pasteur, Paris, France. ² Sorbonne Université, Collège Doctoral, Paris, France. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai, China. ⁴ School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, China. ⁵ Cellular plasticity in age-related pathologies, Department of Developmental & Stem Cell Biology, CNRS UMR 3738, Université Paris Cité, Institut Pasteur, Paris, France. han.li@pasteur.fr.）

出处： Nature aging 2026

摘要： Cellular senescence is an evolutionarily conserved stress response that contributes to tissue repair and tumor suppression, yet its accumulation is al ...

作者： Huan Zhao ^{# 1}, Hui Chen ^{# 1}, Zhixin Kang ^{# 2}, Xiuzhen Huang ¹, Jingting Zhu ¹, Zixin Liu ¹, Xiuxiu Liu ¹, Ximeng Han ¹, Jie Lu ³, Bin Zhou ^{1 2 4} （Affiliations ¹ Chinese Academy of Sciences Center for Excellence in Molecular Cell Science-The Chinese University of Hong Kong Joint Laboratories, New Cornerstone Science Laboratory, State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China. ² Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. ³ Department of Gastroenterology, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁴ School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.）

出处： Proceedings of the National Academy of Sciences of the United States of America 2026

关键词： diabetes;dual recombinases;lineage tracing;pancreatic beta cell proliferation.

摘要： Pancreatic beta cell generation and proliferation primarily rely on the self renewal of preexisting beta cells, making precise quantification of beta ...

作者： Jia-Chun Lu ^{# 1}, Min-Li Xiong ^{# 2}, Zhi-Qi Cai ^{# 3 4}, Ting Mao ^{# 1}, Long Tang ^{3 4}, Hui-Yi Li ¹, Ming-Yi Xu ⁵, Sheng-Zheng Luo ^{6 7 8} （Affiliations ¹ Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200123, China. ² Outpatient Department of Shanghai University of International Business and Economics, Shanghai, 201620, China. ³ Ningde Municipal Hospital, Ningde, Fujian, 355099, China. ⁴ Ningde Clinical Medical College of Fujian Medical University, Ningde, Fujian, 352101, China. ⁵ Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200123, China. xumingyi@tongji.edu.cn. ⁶ Ningde Municipal Hospital, Ningde, Fujian, 355099, China. luoshengzheng2007@163.com. ⁷ Ningde Clinical Medical College of Fujian Medical University, Ningde, Fujian, 352101, China. luoshengzheng2007@163.com. ⁸ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, 200080, China. luoshengzheng2007@163.com.）

出处： BMC gastroenterology 2026

关键词： B cell;single-cell RNA sequencing;Fcer2α;Metabolic Dysfunction-Associated Steatohepatitis.

作者： Chenwang Zhang ^{1 2}, Nan Liang ³, Wenbo Li ¹, Shuai Xu ¹, Peng Li ¹, Wanze Ni ^{1 4}, Na Li ¹, Sha Han ¹, Ningjing Ou ^{1 2 3 5}, Haowei Bai ¹, Yuxiang Zhang ¹, Furong Bai ¹, Yifan Sun ¹, Dewei Qian ^{1 4}, Xinjie Bu ^{1 4}, Erlei Zhi ¹, Ruhui Tian ¹, Yuhua Huang ¹, Jingpeng Zhao ¹, Fujun Zhao ¹, Hao Chen ³, Zheng Li ^{1 2 4}, Chencheng Yao ¹ （Affiliations ¹ Department of Andrology, the Center for Men's Health, Urologic Medical Center, Reproductive Medicine Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, China. ³ Department of Human Cell Biology and Genetics, SUSTech Homeostatic Medicine Institute, Joint Laboratory of Guangdong & Hong Kong Universities For Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China. ⁴ Taizhou School of Clinical Medicine, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China. ⁵ Department of Urology, Department of Interventional Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026

关键词： genetic defects;mRNA‐LNP delivery;male infertility;restoration of spermatogenesis;spermatogenic disorders.

摘要： Uniform testicular maturation arrest is a severe form of male infertility characterized by the presence of germ cells that do not complete spermatogen ...

作者： Jie Xu ^{# 1}, Jian Huang ^{# 1}, Rong Zou ¹, Yuliang Deng ¹, Hong Xie ², Wanqiu Huang ³, Zhaoqi Zhang ^{4 5} （Affiliations ¹ Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China. ² Department of Gynecology, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University, Shenzhen, Guangdong Province, 518120, China. ³ Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China. wqhuang@sjtu.edu.cn. ⁴ Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China. drzzq@foxmail.com. ⁵ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. drzzq@foxmail.com.）

出处： Naunyn-Schmiedeberg's archives of pharmacology 2026

关键词： Cistanches Herba;Dipeptidyl peptidase 4;Molecular docking;Network pharmacology;Quercetin;Thyroid cancer.

摘要： Thyroid cancer is a prevalent endocrine malignancy with a rising incidence and limited therapeutic options for advanced disease. Cistanches Herba, a t ...