作者： Xuebing Jia  ¹, Jianbei Xi  ², Binle Tian  ³, Yuanyuan Zhang  ², Zhilong Wang  ², Fan Wang  ⁴, Zheng Li  ⁵, Jiang Long  ⁶, JianFei Wang  ², Guo-Huang Fan  ⁷, Qi Li  ⁸ （Affiliations ¹ Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. ² Immunophage Biotech LtD, Shanghai, China. ³ Shanghai Genaral Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Shanghai general hospital, Shanghai, China. ⁵ IPS (Brazil), Shanghai, China. ⁶ Department of Pancreatic and Hepatobiliary Surgery, Shanghai, China. ⁷ Immunophage Biotech co., ltd, Shanghai, China. ⁸ Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Cancer immunology research 2023

摘要： Pancreatic cancer is a deadly disease that is largely resistant to immunotherapy, in part because of the accumulation of immunosuppressive cells in th ...

作者： Shimin Yang ^{#  1};Yifan Luo ^{#  1};Dongmei Zhou  ¹;Jiangdong Xiang  ¹;Xiaowei Xi  ¹ （Affiliation ¹ Department of Gynecology and Obstetrics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Translational cancer research 2023

关键词： 5-Methylcytosine (m5C);Endometrial cancer;RNA methylation;cell adhesion;prognosis.

摘要： Background: RNA methylation is a significant form of post-transcriptional modification that has been implicated in various diseases, including cancers ...

作者： Shanshan Hu ^{#  1};Yilai Wu ^{#  1   2};Jiajie Luan  ²;Shuowen Wang  ³;Guorong Fan  ⁴ （Affiliations ¹ Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Department of Pharmacy, The First Affiliated Hospital of Wannan Medical College, Anhui, China. ³ Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. wangshuowensy@163.com. ⁴ Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. guorfan@163.com.）

出处： Journal of cancer research and clinical oncology 2023

关键词： Cost–utility analysis;HER2-positive metastatic breast;Price exploring;Trastuzumab deruxtecan;Trastuzumab emtansine.

摘要： Purpose: Trastuzumab deruxtecan (T-DXd) expressed substantial improvement in the progression-free survival and overall survival contrasted with trastu ...

作者： Linchen He  ¹, Shoshana Evans  ¹, Christina Norris  ², Karoline Barkjohn  ^{3   4}, Xiaoxing Cui  ⁵, Zhen Li  ⁶, Xiaojian Zhou  ⁶, Feng Li  ⁷, Yinping Zhang  ^{8   9}, Marilyn Black  ¹⁰, Michael H Bergin  ³, Junfeng Jim Zhang  ^{5   11   12} （Affiliations ¹ Department of Community and Population Health, College of Health, Lehigh University, Bethlehem, Pennsylvania, United States of America. ² Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. ³ Department of Civil and Environmental Engineering, Duke University, Durham, North Carolina, United States of America. ⁴ Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America. ⁵ Nicholas School of the Environment, Duke University, Durham, North Carolina, United States of America. ⁶ Department of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. ⁷ Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. ⁸ Department of Building Science, Tsinghua University, Beijing, China. ⁹ Beijing Key Laboratory of Indoor Air Quality Evaluation and Control, Beijing, China. ¹⁰ Underwriters Laboratories, Inc, Marietta, Georgia, United States of America. ¹¹ Duke Global Health Institute, Duke University, Durham, North Carolina, United States of America. ¹² Duke Kunshan University, Kunshan, Jiangsu Province, China.）

出处： PloS one 2023

摘要： Ambient temperature and relative humidity can affect asthma symptoms. Apparent temperature is a measure of temperature perceived by humans that takes ...

作者： Yanli Zhang  ¹;Hui Liu  ²;Zongxin Chen  ¹;Jialei Meng  ³;Yunfeng Li  ³;Luyao Qi  ³;Suiliang Zhang  ¹;Xiaofeng Chen  ⁴;Ming Lei  ¹ （Affiliations ¹ Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Shanghai, 200137, People's Republic of China. ² Shanghai General Hospital affiliated to Shanghai Jiaotong University, 100 Haining Road, Shanghai, 200080, People's Republic of China. ³ Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Shanghai, 201203, People's Republic of China. ⁴ National Research Institute for Family Planning, 12 Dahuisi Road, Beijing, 100081, People's Republic of China.）

出处： Acta crystallographica Section B, Structural science, crystal engineering and materials 2023

关键词： co-amorphous;crystal engineering;dissolution;drug–drug interaction;pharmaceutical cocrystal;stability.

摘要： A drug-drug cocrystal created with two antithrombotic-active ingredients from herbs, honokiol (HON) and ligustrazine (TMP, 1:1), was synthesized and c ...

作者： Han Liu ^{#  1};Chao Zeng ^{#  2};Mingming Jiang  ¹;Yue Dai  ¹;Minyi Xu  ¹;Fangfang Zhou  ¹;Yaling Wang  ¹;Alessandra Pulliero  ³;Tomasz Sobierajski  ⁴;Whitney Nesser  ⁵;Motoki Matsuura  ⁶;Lei Wang  ¹;Jiaying Wu  ²;Muyuan Ji  ^{7   8} （Affiliations ¹ Department of Clinical Laboratory, Shanghai Eighth People's Hospital, Shanghai, China. ² Department of Laboratory Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Health Sciences, University of Genoa, Genoa, Italy. ⁴ The Center of Sociomedical Research, Faculty of Applied Social Sciences and Resocialization, University of Warsaw, Warsaw, Poland. ⁵ Department of Applied Clinical and Educational Sciences, Indiana State University, Terre Haute, IN, USA. ⁶ Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo, Japan. ⁷ Department of Hematology and Oncology, Children's Hospital Affiliated to Shandong University, Jinan, China. ⁸ Department of Hematology and Oncology, Jinan Children's Hospital, Jinan, China.）

出处： Translational cancer research 2023

关键词： Human papillomavirus (HPV);t-Distributed Stochastic Neighbor Embedding (TSNE);vaccine.

摘要： Background: Human papillomavirus (HPV) can cause various gynecological diseases, create a long-term inflammatory immune microenvironment, and induce t ...

作者： Ying Xiao;Yu Qian;Chenhao Yang;Haidong Zou （¹Department of Ophthalmology, Children’s Hospital of Fudan University, National Children’s Medical Center, 399 Wanyuan Road, 201102, Shanghai, China;²Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China;³Shanghai Key Laboratory of Fundus Diseases, Shanghai, China;⁴Shanghai Eye Diseases Prevention & Treatment Center, Shanghai Eye Hospital, Shanghai, China;⁵National Clinical Research Center for Eye Diseases, Shanghai, China;⁶Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China）

出处： BMC Ophthalmology 2023

关键词： T1DM children;Lens thickness;Lens power;Myopia

摘要： Background This study compares the ocular biometry with or without myopia in children with type 1 diabetes mellitus (T1DM) and healthy children in Ch ...

作者： Yuying Liu;Lu Liu;Mingming Liu;Xuetong Wang;Chengcheng Jin;Bingbing Ni;Bilian Ke （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² National Clinical Research Center for Eye Diseases, Shanghai, China. ³ Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. ⁴ Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai, China. ⁵ Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ⁶ Department of Electronic Engineering, Shanghai Jiao Tong University, Shanghai, China.）

出处： Acta ophthalmologica 2023

关键词： accommodation;augmented reality;choroidal blood perfusion;pupil diameter;three-dimension.

摘要： Purpose: The purpose of the study was to investigate the changes of choroidal blood perfusion in different layers and quadrants and its possible relat ...

作者： Xichen Wan;Songjiao Zhao;Yiqin Dai;Jing Zhang;Yan Shen;Lan Gong;Qihua Le （Affiliations ¹ Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Fudan, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Research Centre, Eye, Ear, Nose and Throat Hospital of Fudan University, Fudan, China. ⁴ Myopia Key Laboratory of Ministry of Health, Eye, Ear, Nose and Throat Hospital of Fudan University, Fudan, China.）

出处： Cell proliferation 2023

摘要： Our previous finding revealed that WNT16b promoted the proliferation of human limbal epithelial stem cells (hLESCs) through a β-catenin independent pa ...

作者： Xiangui He;Jingjing Wang;Zhuoting Zhu;Kaidi Xiang;Xinzi Zhang;Bo Zhang;Jun Chen;Jinliuxing Yang;Linlin Du;Chunjin Niu;Mei Leng;Jiannan Huang;Kun Liu;Haidong Zou;Mingguang He;Xun Xu （Affiliations ¹ Department of Clinical Research, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center and Shanghai Children Myopia Institute, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Center of Eye Shanghai Key Laboratory of Ocular Fundus Diseases, Engineering Center for Visual Science and Photomedicine, Shanghai, China. ³ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. ⁴ Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia. ⁵ Division of Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia. ⁶ Department of Ophthalmology Prevention, Changning Center for Disease Control and Prevention, Shanghai, China. ⁷ Department of Teaching and Research, Changning Institute of Education, Shanghai, China.）

出处： JAMA network open 2023

摘要： Importance: Myopia is a global concern, but effective prevention measures remain limited. Premyopia is a refractive state in which children are at hig ...