作者： Zhenzhen Li;Beijie Zheng;Chenchen Liu;Xiang Zhao;Yupeng Zhao;Xiangrui Wang;Lei Hou;Zhongwei Yang （Affiliations ¹ Department of Pharmacy, Zhongshan Hospital Wusong Branch, Fudan University, 200940 Shanghai, China. ² Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200127 Shanghai, China. ³ Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 200081 Shanghai, China. ⁴ Department of Surgery of Spine and Spinal Cord, Henan University People's Hospital, Henan Provincial People's Hospital, Henan, Zhengzhou 453003, China. ⁵ Department of Anesthesiology and Critical Care Medicine, Shanghai East Hospital, Tongji University School of Medicine, 200120 Shanghai, China. ⁶ Shanghai East Hospital Ji'an Hospital, 80 Ji'an South Road, Ji'an City, 343000 Jiangxi Province, China.）

出处： Stem cells international 2023

摘要： Type II alveolar epithelial cell (AECII) apoptosis is one of the most vital causes of sepsis-induced acute respiratory distress syndrome (ARDS). Recen ...

作者： Qiong Liao;Yuwei Dong;Binghang Li;Jie Qin;Yangwei Cao;Wenjuan Tu;Lungen Lu （Affiliations ¹ Department of Infectious Disease, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. ² Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Infectious Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.）

出处： Annals of translational medicine 2023

关键词： Hepatic stellate cell (HSC);Y-box binding protein 1 (YB-1);liver fibrosis;transforming growth factor-beta 3 (TGF-β3).

摘要： Background: Spurred by the seriousness of liver fibrosis, we evaluated the correlation between Y-box binding protein 1 (YB-1) and transforming growth ...

作者： Ruifeng Zheng;Ying Zhong;Senxiang Yan;Hongcheng Sun;Haibin Shen;Kejie Huang （¹College of Information Science Electronic Engineering, Zhejiang University, Hangzhou, China ²Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China ³Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China）

出处： IEEE Transactions on Medical Imaging 2023

关键词： Image segmentation;Task analysis;Three-dimensional displays;Visualization;Self-supervised learning;Medical diagnostic imaging;Representation learning

摘要： Automated medical image segmentation for organs or lesions plays an essential role in clinical diagnoses and treatment plannings. However, training an ...

作者： Wei Gong;Zhuoting Zhu;Gabriella Bulloch;Jingjing Wang;Jun Chen;Linlin Du;Jinliuxing Yang;Bo Zhang;Xiangui He;Haidong Zou;Xun Xu;Junjie Deng;Jiannan Huang （Affiliations ¹ Shanghai Eye Diseases Prevention & Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Shanghai, China. ² Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. ³ Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.）

出处： Clinical & experimental optometry 2023

关键词： Anisometropia;children;cylindrical power;high myopia;spherical power.

摘要： Clinical relevance: Anisometropia can affect visual development in children. Investigations of anisometropia in high myopes would explore potential ca ...

作者： Lulu Liu;Yanjia Fang;Xiaodan Ding;Weihua Zhou;Remi Terranova;Yan Zhang;He Wang （Affiliations ¹ Novartis Institutes for BioMedical Research, 181 Massachusetts Ave., Cambridge, MA, USA. ² Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai, China. ³ Department of Hematology, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, No. 650 Songjiang Road, Shanghai, China. ⁴ Novartis Institutes for BioMedical Research, Kohlenstrasse 44, Novartis Campus, 4056, Basel, Switzerland. ⁵ Department of Hematology, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, No. 650 Songjiang Road, Shanghai, China. yan.zhang19510@shgh.cn. ⁶ Novartis Institutes for BioMedical Research, 181 Massachusetts Ave., Cambridge, MA, USA. he.wang@novartis.com. ⁷ Novartis Institutes for BioMedical Research, 4218 Jinke Road, Shanghai, China. he.wang@novartis.com.）

出处： Experimental hematology & oncology 2023

关键词： Erythropoiesis;Hematopoiesis;Hematopoietic stem cell;Wdr5.

摘要： WDR5 is a highly conserved protein that performs multiple scaffolding functions in the context of chromatin. However, efforts to understand the functi ...

作者： Lin Gao;Yuanli Wang;Wei Wen;Yunyan Duan;Zhaoyang Li;Erle Dang;Peng Li;Lei Yu;Chenxi Zhou;Meiheng Lu;Gang Wang （Affiliations ¹ Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. ² Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Medical Technology, Xi'an Medical University, Xi'an, China. ⁴ Department of Radiology, The Affiliated Hospital of Qingdao Binhai University, Qingdao, China. ⁵ Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.）

出处： Lasers in surgery and medicine 2023

关键词： fractional carbon dioxide laser;sexual function;stress urinary incontinence;vaginal tactile imaging.

摘要： Objective: To demonstrate remodeling of vaginal biomechanical and physiological properties using vaginal fractional carbon dioxide (CO₂ ) l ...

作者： Xiang Wu;Yuyao Sun;Xiao Xu;Ewout W Steyerberg;Isabel R A Retel Helmrich;Fiona Lecky;Jianying Guo;Xiang Li;Junfeng Feng;Qing Mao;Guotong Xie;Andrew I R Maas;Guoyi Gao;Jiyao Jiang （Affiliations ¹ Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Ping An Healthcare Technology, Beijing, China. ³ Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. ⁴ Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. ⁵ Centre for Urgent and emergency care Research (CURE), Health Services Research Section, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, United Kingdom. ⁶ Shanghai Institute of Head Trauma, Shanghai, China. ⁷ Brain Injury Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁸ Ping An Health Cloud Company Ltd., Beijing, China. ⁹ Ping An International Smart City Technology Co., Ltd., Beijing, China. ¹⁰ Department of Neurosurgery, Antwerp University Hospital, Edegem, Belgium. ¹¹ University of Antwerp, Edegem, Belgium.）

出处： Journal of neurotrauma 2023

关键词： extreme gradient boosting;logistic regression;machine learning;prognostic model;traumatic brain injury.

摘要： Prognostic prediction of traumatic brain injury (TBI) in patients is crucial in clinical decision and health care policy making. This study aimed to d ...

作者： Guoyan Wang;Lei Chen;Xinjian Lei;Senlin Qin;Huijun Geng;Yining Zheng;Chao Xia;Junhu Yao;Tong Meng;Lu Deng （Affiliations ¹ College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China. ² Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200240, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023

关键词： FLCN phosphorylation;insulin;mTORC1;tumorigenesis.

摘要： The amino acid-stimulated Rag GTPase pathway is one of the main pathways that regulate mechanistic target of rapamycin complex 1 (mTORC1) activation a ...

作者： Bo Guan;Xiao-Qiang Chen;Yan Liu;Hui Zhou;Ming-Yan Yang;Hong-Wei Zheng;Shi-Jun Li;Jian Cao （Affiliations ¹ Medical School of Chinese PLA General Hospital, Beijing, China. ² Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ³ Xiangya School of Nursing, Central South University, Changsha, Hunan, China. ⁴ Department of Cardiology, Tangshan Gongren Hospital Affiliated to Hebei Medical University, Tangshan, China. ⁵ Geriatric Cardiology Department of the Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.）

出处： Journal of geriatric cardiology : JGC 2023

摘要： Background: Observational studies suggest inverse associations between serum vitamin levels and the risk of heart failure (HF). However, the causal ef ...

作者： Wentao Ji;Xiaoting Zhang;Chao Sang;Huixian Wang;Keqian Zhou;Yan Zhang;Lulong Bo （¹Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai 200433, China;²These authors contributed equally to this paper.;³Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China;⁴College of Basic Medicine, Naval Medical University, Shanghai 200433, China）

出处： Heliyon 2023

关键词： Punicalin;Acute lung injury;Neutrophil extracellular trap;Cytokine;NF-κB

摘要： Background Acute lung injury (ALI) remains a significant cause of morbidity and mortality in critically ill patients. Novel therapies interfering with ...