作者： Chen Guo  ¹, Randy Donelson  ¹, Zhengyu Wang  ², Amanda Billups  ³, Tongjia Liu  ⁴, Emma Torii  ⁵, Danielle Burroughs  ⁶, Marcus Flowers  ³, Asheesh Shukla  ⁴, Ryan Jeo  ⁴, Davis Seelig  ⁵, Chun Wang  ³, Jafar Golzarian  ¹ （Affiliations ¹ Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, United States. ² Vascular and Interventional Radiology Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. ³ Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States. ⁴ Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States. ⁵ Comparative Pathology Shared Resource, University of Minnesota, College of Veterinary Medicine, St. Paul, Minnesota 55108, United States. ⁶ Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota 55455, United States.）

出处： ACS applied bio materials 2025

关键词： UV-initiated cross-linking;biodegradability;biopolymer;drug delivery;hydrogel microspheres;transarterial embolization.

摘要： Transarterial embolization (TAE) is an image-guided, minimally invasive procedure for treating various clinical conditions by delivering embolic agent ...

作者： Qianmin Ge ^{#  1}, Jinyan Lin ^{#  2}, YeYe Zhang  ², Hong Wei  ¹, Min Kang  ¹, Jie Zou  ¹, Qian Ling  ¹, Hui Huang  ¹, Sanhua Xu  ¹, Xu Chen  ¹, Yi Shao  ³ （Affiliations ¹ Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. ² School of Science and Center for Theoretical Physics, Hainan University, Haikou, Hainan, 570288, China. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Disease, Shanghai, 200080, China. freebee99@163.com.）

出处： Journal of imaging informatics in medicine 2025

关键词： Classification;Deep convolutional neural network;Diagnosis;In vivo confocal microscope;Meibomian gland dysfunction.

摘要： The objectives of this study are to construct a deep convolutional neural network (DCNN) model to diagnose and classify meibomian gland dysfunction (M ...

作者： Yan Zhu  ^{1   2   3}, Xin Yu  ², Mingxuan Hao  ¹, Yushan Wang  ², Gentao Fan  ², Hongbo Qian  ², Peng Jiang  ², Zhengdong Cai  ³, Zhiwei He  ², Guangxin Zhou  ^{1   2   3   4   5} （Affiliations ¹ Department of Orthopaedics, Jinling Hospital, Affiliated Hospital of Medical School, Southeast University, 210000 Nanjing, China. ² Department of Orthopaedics, Jinling Hospital, Medical School of Nanjing University, Nanjing 210000, China. ³ Department of Orthopaedics, Shanghai General Hospital, Nanjing Medical University, Shanghai 200000, China. ⁴ Wuxi Xishan NJU Institute of Applied Biotechnology, Wuxi 214000, China. ⁵ State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210000, China.）

出处： ACS applied bio materials 2025

关键词： BMP-2 peptide;Bone defects;Controlled release;Osteogenesis;α-TCP/SF microspheres.

摘要： The repair and reconstruction of bone defects remain a challenge in orthopedics. Inadequate mechanical qualities, poor biocompatibility, and insuffici ...

作者： Qian Zhu  ¹, Xiaoxin Liu  ², Yuan Qu  ³, Yan Jiang  ⁴, Xinyi Liu  ⁵, Yu Xiao  ⁶, Kangjia Lv  ⁷, Yupeng Xu  ⁸, Kun Liu  ⁹ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: qelight@sjtu.edu.cn. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: liuxiaoxin99@126.com. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: yyqy32@126.com. ⁴ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: jy_470639444@163.com. ⁵ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: liuxinyi@sjtu.edu.cn. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: whitexy@foxmail.com. ⁷ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: 18315319525@163.com. ⁸ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: kevinxu@sjtu.edu.cn. ⁹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: drliukun@sjtu.edu.cn.）

出处： The journal of nutrition, health & aging 2025

关键词： Diet;Neurodegeneration;Optical coherence tomography;Retina;The UK Biobank.

摘要： Background: Retinal sublayer thickness is associated with both ophthalmic and neurodegenerative diseases, serving as a valuable biomarker. Despite the ...

作者： Haoran Mu  ¹, Qi Zhang  ², Dongqing Zuo  ¹, Jinzeng Wang  ³, Yining Tao  ¹, Zhen Li  ⁴, Xin He  ¹, Huanliang Meng  ¹, Hongsheng Wang  ¹, Jiakang Shen  ¹, Mengxiong Sun  ¹, Yafei Jiang  ¹, Weisong Zhao  ¹, Jing Han  ¹, Mengkai Yang  ¹, Zhuoying Wang  ¹, Yu Lv  ¹, Yuqin Yang  ⁵, Jing Xu  ¹, Tao Zhang  ¹, Liu Yang  ¹, Jun Lin  ⁶, Feng Tang  ⁷, Renhong Tang  ⁸, Haiyan Hu  ⁹, Zhengdong Cai  ¹, Wei Sun  ¹⁰, Yingqi Hua  ¹¹ （Affiliations ¹ Department of Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. ² Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ National Research Center for Translational Medicine at Shanghai, State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: jz.wang@sjtu.edu.cn. ⁴ State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, China; Simcere Zaiming Pharmaceutical Co., Ltd., Shanghai, China. ⁵ Department of Laboratory Animal Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, China; Jiangsu Simcere Pharmaceutical Co., Ltd., Nanjing, China. ⁸ State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, China; Jiangsu Simcere Pharmaceutical Co., Ltd., Nanjing, China; Simcere Zaiming Pharmaceutical Co., Ltd., Shanghai, China. ⁹ The Drug and Device Phase I Clinical Research Ward/Demonstration Research Ward of Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁰ Department of Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. Electronic address: viv-sun@sjtu.edu.cn. ¹¹ Department of Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. Electronic address: hua_yingqi@163.com.）

出处： Cell reports. Medicine 2025

关键词： IKZF1;MAT2A;MTAP deletion;PD-L1;immunotherapy;methionine metabolism;osteosarcoma;tumor microenvironment.

摘要： Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomic ...

作者： Yun Xie¹;Hui Lv¹;Daonan Chen¹;Peijie Huang¹;Zhigang Zhou¹;Ruilan Wang² （¹Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, Shanghai 201600, PR China;²Corresponding author at: Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Songjiang, Shanghai 201600, PR China.;Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, Shanghai 201600, PR China）

出处： International Journal of Cardiology: Heart & Vasculature 2025

关键词： Sepsis;Acute myocardial injury;CD36

摘要： Background: Sepsis-induced myocardial injury (SIMI) is a prevalent form of organ dysfunction with a significant impact on the mortality rate among sep ...

作者： Guangze Shao  ¹, Jitu Xu  ¹, Chencheng Hu  ¹, Wenyao Jia  ¹, Xitong Xu  ¹, Yue Gu  ¹, Luming Zhang  ², Zhihuang Zheng  ³, Jiayan Zhong  ¹, Siqi Zhu  ¹, Shenghao Meng  ¹, Zhonghua Zhao  ¹, Zhigang Zhang  ¹, Jun Liu  ³, Yanyong Xu  ^{4   5}, Huijuan Wu  ¹ （Affiliations ¹ Department of Pathology of School of Basic Medical Sciences, Fudan University, Kidney and Dialysis Institute of Shanghai, Shanghai, PR China. ² School of Biological Sciences, College of Life Science, Northwest A&F University, Xianyang, PR China. ³ Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China. ⁴ Frontier Innovation Center of School of Basic Medical Sciences, Fudan University, Shanghai, PR China. ⁵ Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Pathology of School of Basic Medical Sciences, Fudan University, Shanghai, PR China.）

出处： The Journal of pathology 2025

关键词： TEAD3;YAP;focal segmental glomerulosclerosis (FSGS);podocyte adhesion;α3β1 integrin.

摘要： Severe proteinuria in focal segmental glomerulosclerosis (FSGS) is closely associated with decreased adhesion, and subsequent loss, of podocytes. Yes- ...

作者： Yiwei Wu  ^{1   2}, Ying Xiao  ³, Lipu Cui  ^{1   2}, Xinran Qin  ^{1   2}, Shuli Chen  ^{1   2}, Qingyu An  ^{1   2}, Tianyi Yuan  ^{1   2}, Qiurong Lin  ⁴, Haidong Zou  ^{1   2   4}, Xiangui He  ⁴, Chenhao Yang  ³, Peiyao Jin  ^{1   2} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² National Clinical Research Centre for Eye Diseases, Shanghai Clinical Research Centre for Eye Diseases, Shanghai Key Clinical Specialty, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Centre for Visual Science and Photomedicine, Shanghai Engineering Centre for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ³ Department of Ophthalmology, Children's Hospital of Fudan University, Shanghai, China. ⁴ Shanghai Eye Diseases Prevention and Treatment Centre, Shanghai Eye Hospital, Shanghai, China.）

出处： Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 2025

关键词： choroidal thickness;diabetic retinopathy;retinal thickness;swept‐source optical coherence tomography;type 1 diabetes mellitus.

摘要： Purpose: To explore the longitudinal changes in retinal and choroidal thickness and their relation with the onset of type 1 diabetes mellitus (T1DM) i ...

作者： Yiming Yang  ¹, Xiaoyan Hu  ², Liu Yang  ³, Hongai Zhang  ⁴, Honghao Zheng  ⁵, Zhenxing Shen  ⁶ （Affiliations ¹ Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China; Key Lab of Aerosol Chemistry & Physics, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, 710049, China. ² Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China. ³ Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China; Key Lab of Aerosol Chemistry & Physics, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, 710049, China. Electronic address: yangliu2013@xjtu.edu.cn. ⁴ Department of Neonatology, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Rd, Songjiang District, Shanghai 201620, China. ⁵ Key Lab of Aerosol Chemistry & Physics, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, 710049, China. ⁶ Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China. Electronic address: zxshen@mail.xjtu.edu.cn.）

出处： Environmental pollution (Barking, Essex : 1987) 2025

关键词： Airborne bacterial community;Co-occurrence analysis;PM(2.5);Potential pathogenic bacteria;STAMP analysis.

摘要： Bioaerosols significantly influence air quality and human health. This study investigated the diversity, structure, and interaction of bacterial commu ...

作者： Yun Xie  ¹, Ruilan Wang  ² （Affiliations ¹ Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, People's Republic of China. ² Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, People's Republic of China. Electronic address: wangyusun@hotmail.com.）

出处： Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2025