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作者: Björn Hegner  1   2, Tobias Kretzschmar  3, Nan Zhu  1   4, Gunnar Kleinau  5, Hongfan Zhao  1, Julian Kamhieh-Milz  6, Julia Hilger  7, Ralf Schindler  1   8, Patrick Scheerer  5   9, Gabriela Riemekasten  10, Aurélie Philippe  1   11, Rusan Catar  1 (Affiliations 1 Department of Nephrology and Critical Care Medicine, Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. 2 Vitanas Hospital for Geriatric Medicine, Berlin, Germany. 3 Department of Internal Medicine Emergency Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. 4 Shanghai general hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. 5 Institute of Medical Physics and Biophysics, Group Protein X-ray Crystallography and Signal Transduction, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. 6 Department of Transfusion Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. 7 Department of Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. 8 Nierenzentrum Zehlendorf, Berlin, Germany. 9 DZHK (German Centre for Cardiovascular Research), partner site Berlin. 10 Department of Rheumatology and Clinical Immunology, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany. 11 BIH Biomedical Innovation Academy, Berlin Institute of Health at Charité - Universitätsmedizin Berlin (BIH), Berlin, Germany.)

出处: Rheumatology (Oxford, England) 2022

关键词: G-protein coupled receptors;Scleroderma renal crisis;agonistic autoantibodies;receptor hypersensitization

摘要: Objectives: Scleroderma renal crisis (SRC) is a rare vascular complication of systemic sclerosis with substantial risks for end-stage renal disease an ...

作者: Zhenzhen Wei  1   2, Jing Zhou  1, Hao Yu  1, Yunzhou Pu  1, Yuelei Cheng  1, Yi Zhang  1, Qing Ji  1, Huirong Zhu  1 (Affiliations 1 Department of Medical Oncology & Cancer Institute of Integrative Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. 2 Medical Experiment Center, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201803, China.)

出处: Evidence-based complementary and alternative medicine : eCAM 2022

摘要: Background: Oxaliplatin (L-OHP) is a common chemotherapy drug used in the treatment of colorectal cancer (CRC). Our previous work showed that Zuo Jin ...

作者: Xiushi Ni  1, Fang Wu  2, Juan Song  3, Lina An  1, Qianwen Jiang  2, Tingting Bai  2, Jianye Wang  4, Pulin Yu  4, Cuntai Zhang  5, Jinhui Wu  3, Geriatrics Branch of the Chinese Medical Association; Expert Group of the Chinese Expert Consensus on Assessment of Cognitive Impairment in the Elderly (Affiliations 1 Department of Geriatrics Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China. 2 Department of Geriatrics Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China. 3 Center of Gerontology and Geriatrics, National Clinical Research Center for Geriatrics West China Hospital, Sichuan University Chengdu China. 4 Beijing Hospital Beijing China. 5 Department of Geriatrics, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China.)

出处: Aging medicine (Milton (N.S.W)) 2022

关键词: assessment;cognitive impairment;elderly;expert consensus.

摘要: Cognitive impairment is a term that refers to the impairment of one or more cognitive domains to varying degrees caused by a variety of reasons. It is ...

作者: Biao Wang  1, Rongzhu Tang  2, Shaohong Wu  3, Ming Liu  4, Fariha Kanwal  5, Muhammad Fayyaz Ur Rehman  6, Fang Wu  7, Jianping Zhu  3 (Affiliations 1 Department of Gastrointestinal Surgery, Renmin Hospital, Hubei University of Medicine, No. 39, Chaoyang Middle Road, Shiyan 442000, China. 2 Department of Gastroenterology, Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, No. 358, Datong Road, Pudong New District, Shanghai 200137, China. 3 Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. 4 Department of Emergency, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. 5 Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. 6 Institute of Chemistry, University of Sargodha, Sargodha 40100, Pakistan. 7 Department of Gynecology, Obstetrics and Gynae Hospital, Fudan University, Shanghai 200437, China.)

出处: Diagnostics (Basel, Switzerland) 2022

关键词: CD64 index;abdominal infection;acute pancreatitis;neutrophil.

摘要: Objective: To study the clinical diagnostic value of neutrophil CD64 index, PCT, and CRP in patients with acute pancreatitis with abdominal infection. ...

作者: Lu Cheng  1   2, Jing Hu  1   2, Ling Zhang  1   2, Ning Shen  1   2, Hui Chen  1   2   3   4, Fang Zhang  1   2   3   4 (Affiliations 1 National Clinical Research Center for Eye Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 2 Shanghai Key Laboratory of Fundus Diseases, Shanghai 200080, China. 3 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China. 4 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China.)

出处: Pharmaceuticals (Basel, Switzerland) 2022

关键词: Lenvatinib;orbital adipose tissue;thyroid eye disease;vascular endothelial growth factor receptor.

摘要: Thyroid eye disease (TED) is the most common orbital disease in adults. Targeting expanded orbital adipose tissue (OAT) removed by surgery has therape ...

作者: Yufan Zheng  1   2, Wenrui Sun  2, Zhengyang Wang  3, Jiaying Liu  2, Cong Shan  1, Chenxi He  4, Borui Li  2, Xiao Hu  3, Wenjia Zhu  2, Liyan Liu  5, Fei Lan  4, Changtao Jiang  6, Chao Zhao  2, Xiaobo Li  2, Ning Sun  1   2 (Affiliations 1 Wuxi School of Medicine, Jiangnan University, Jiangsu, China. 2 Department of Physiology and Pathophysiology, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, China. 3 Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 4 Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China. 5 General Practice/International Medical Care Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China.)

出处: Research (Washington, D.C.) 2022

摘要: Pancreatitis is the leading cause of hospitalization in gastroenterology, and no medications are available for treating this disease in current clinic ...

[外文期刊] A novel and efficient murine model of Bietti crystalline dystrophy
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作者: Yafang Wang  1, Yang Liu  1, Shu Liu  1, Xiaomeng Li  1, Xinxin Liu  1   2, Ming Jiao  3, Yuqin Yang  3, Xueting Luo  1   2, Fenghua Wang  1   2   4   5   6, Xiaoling Wan  1   2, Xiaodong Sun  1   2   4   5   6 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, China200080. 2 Shanghai Key Laboratory of Ocular Fundus Diseases, 100 Haining Road, Shanghai, China200080. 3 Laboratory Animal Center, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Shanghai, China201620. 4 Shanghai Engineering Center for Visual Science and Photomedicine, 100 Haining Road, Shanghai, China200080. 5 National Clinical Research Center for Eye Diseases, 100 Haining Road, Shanghai, China200080. 6 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 100 Haining Road, Shanghai, China200080.)

出处: Disease models & mechanisms 2022 Vol.15 No.3 Pdmm049222

关键词: Cyp4v3;Bietti crystalline dystrophy;Lipid accumulation;Mouse model;Retinal degeneration.

摘要: Bietti crystalline dystrophy (BCD) is an autosomal recessive inherited retinal disease, resulting in blindness in most patients. The etiology and deve ...

[外文期刊] Enhancing fractalkine/CX3CR1 signalling pathway can reduce neuroinflammation by attenuating microglia activation in experimental diabetic retinopathy
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作者: Mengmeng Jiang  1, Hai Xie  2, Chaoyang Zhang  3   4, Tianqin Wang  1, Haibin Tian  2, Lixia Lu  2, Jing-Ying Xu  2, Guo-Tong Xu  2, Lin Liu  1, Jingfa Zhang  3   4 (Affiliations 1 Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, China. 4 National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.)

出处: Journal of cellular and molecular medicine 2022

关键词: diabetic retinopathy;fractalkine;microglia;neuroinflammation.

摘要: The concept of diabetic retinopathy (DR) has been extended from microvascular disease to neurovascular disease in which microglia activation plays a r ...

作者: Yumeng Zhang  1, Zhenzhen Zhao  1, Xiaohuan Zhao  1, Hai Xie  2, Chaoyang Zhang  1, Xiaodong Sun  3, Jingfa Zhang  4 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. 2 Tongji Eye Institute, Department of Regenerative Medicine, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: xdsun@sjtu.edu.cn. 4 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: jingfa.zhang@shgh.cn.)

出处: Free radical biology & medicine 2022 Vol.181 P14-28

关键词: HMGB2;Oxidative stress;Photoreceptor;Pyroptosis;Retinal degeneration.

摘要: In the pathogenesis of retinal degenerative diseases, oxidative stress is a key driver leading to photoreceptor death and eventually vision loss. Curr ...

作者: Ying Cao #  1, Ye Tian #  2   3, Heng Zhang  2, Guang-Heng Luo  2, Zhao-Lin Sun  2, Shu-Jie Xia  4 (Affiliations 1 Guizhou University School of Medicine, Guiyang, 550025, Guizhou, China. 2 Department of Urology, Guizhou Provincial People\'s Hospital, Guiyang, 550002, Guizhou, China. 3 Department of Urology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. 4 Department of Urology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. xsj4017@163.com.)

出处: International urology and nephrology 2022 Vol.54 No.3 P499-508

关键词: LUTS;Prostate fibrosis;Sex hormone;TGF-β/Smad signaling pathway.

摘要: Objective: The present study aimed to investigate the effects of an imbalance in the estrogen/androgen ratio on prostate fibrosis. Methods: Different ...

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