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作者: Huidan Li  1, Xiaorui Wang  1, Jing Zhu  2, Bingzhe Yang  3, Jiatao Lou  1 (Affiliations 1 Clinical Laboratory Medicine Center, Shanghai General Hospital, Shanghai, China. 2 Clinical Laboratory Medicine Center, Jiading Branch of Shanghai General Hospital, Shanghai, China. 3 School of Medicine, Shanghai Jiao Tong University, Shanghai, China.)

出处: Biomolecules & biomedicine 2024

摘要: Psoriasis is a globally prevalent chronic inflammatory skin disease. This study aimed to scrutinize the hub genes related to inflammation and potentia ...

作者: Greg Petruncio  1, Kyung Hyeon Lee  2, Michael Girgis  3, Zachary Shellnutt  4, Zach Beaulac  4, Jiangdong Xiang  5, Soo Hyeon Lee  6, Xuejun Peng  7, Marie Burdick  8, Schroeder M Noble  9, Yun M Shim  10, Mikell Paige  11 (Affiliations 1 Department of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States; Center for Molecular Engineering, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States. Electronic address: gpetrunc@gmu.edu. 2 Department of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States; Center for Molecular Engineering, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States; Bacterial Diseases Branch, Wound Infections Department, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910, United States. 3 Center for Molecular Engineering, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States; Department of Bioengineering, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States. 4 Department of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States. 5 Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 6 Bacterial Diseases Branch, Wound Infections Department, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910, United States. 7 Bruker Scientific LLC., 101 Daggett Drive, San Jose CA, 95134, United States. 8 Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, P.O. Box 800546, Charlottesville, VA, 22908, United States. 9 Bacterial Diseases Branch, Wound Infections Department, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD, 20910, United States. Electronic address: schroeder.m.noble.civ@health.mil. 10 Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, P.O. Box 800546, Charlottesville, VA, 22908, United States. Electronic address: yss6n@uvahealth.org. 11 Department of Chemistry & Biochemistry, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States; Center for Molecular Engineering, George Mason University, 10920 George Mason Circle, Manassas, VA, 20110, United States. Electronic address: mpaige3@gmu.edu.)

出处: European journal of medicinal chemistry 2024

关键词: Aminopeptidase;Enzyme activation;Leukotriene A(4)hydrolase;Ullmann cross-Coupling.

摘要: Activation of the aminopeptidase (AP) activity of leukotriene A4 hydrolase (LTA4H) presents a potential therapeutic strategy for ...

作者: Xiaomin Luo1;Min Tang1;Xiaohui Wei1;Yongde Peng1CA11Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Journal of Affective Disorders 2024

摘要: Background The association between magnesium status and sleep quality is unclear. The aim of this study was to determine the relationship between rena ...

作者: Sihan Du  1, Ximin Shen  2, Yi Sun  2, Jia Li  2, Juan Wang  2, Yiting Cai  3, He Li  4 (Affiliations 1 Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China; Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. 2 Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China. 3 Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China. Electronic address: caiyitingd@qq.com. 4 Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China. Electronic address: lihe@bjmu.edu.cn.)

出处: Clinics and research in hepatology and gastroenterology 2024

关键词: HBV e antigen;PreS1;alanine aminotransferase;hepatitis B;viral hepatitis.

摘要: Background and aim: Hepatitis B virus (HBV) infection presents with indicators of varying clinical significance. We aimed to evaluate the correlation ...

作者: Dongjie Chen1,2,3 na1;Pengyi Liu1,2,3 na1;Xiongxiong Lu1,2,3 na1;Jingfeng Li1,2,3 na1;Debin Qi4 na1;Longjun Zang5;Jiayu Lin1,2,3;Yihao Liu1,2,3;Shuyu Zhai1,2,3;Da Fu1,2,3;Yuanchi Weng1,2,3;Hongzhe Li 1,2,3 & …Baiyong Shen1,2,31Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China;2Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research for Pancreatic Neoplasms, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China;3State Key Laboratory of Oncogenes and Related Genes, Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China;4Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;5Department of General Surgery, Taiyuan Central Hospital, Taiyuan, Shanxi, 030009, China)

出处: Journal of Experimental & Clinical Cancer Research 2024

关键词: Lactate metabolism;Immunotherapy;Survival prognostication;Pan-cancer analysis;scRNA-seq

摘要: Background Immunotherapy has emerged as a potent clinical approach for cancer treatment, but only subsets of cancer patients can benefit from it. Tar ...

作者: Jing Liao1;Miaomiao Yuan2;Ziqiang Xu3;Youbin Zheng4;Zhe Wang5;Qitong Huang11Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Key Laboratory of Tissue Engineering of Jiangxi Province, Key Laboratory of Biomedical Sensors of Ganzhou, School of Medical and Information Engineering, School of Pharmacy, Science Research Center, Gannan Medical University, Ganzhou, China;2Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;3School of Materials Science and Engineering, Hubei University, Wuhan, China;4Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool, United Kingdom;5School of Biology and Agricultural Engineering, Jilin University, Changchun, China)

出处: Frontiers in Bioengineering and Biotechnology 2024

关键词: smart nanomaterials;biosensing;nanozyme;cancer therapies;intelligent drug-delivery system;early-diagnosis

作者: Peng Wu #  1, Yi-Qun Jiang #  2, Feng-Li Si #  1, Huan-Ying Wang #  1, Xiao-Bo Song  1, Chun-Feng Sheng  1, Xun Xu  1, Fan Li  3, Jing Zhang  4 (Affiliations 1 Department of Respiratory and Critical Care, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China;Songjiang District Central Hospital, Shanghai, 201600, China. 2 Department of General Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Respiratory and Critical Care, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China;Songjiang District Central Hospital, Shanghai, 201600, China. lifanking2015@163.com. 4 Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China. jingatlas@outlook.com.)

出处: NPJ primary care respiratory medicine 2024

摘要: This study aimed to investigate the real-world standardisation and adherence of medical treatment regimens in patients with chronic obstructive pulmon ...

作者: Kangkang Ou  1, Yang Liu  2, Lili Deng  3, Shiyan Chen  4, Song Gu  5, Baoxiu Wang  6 (Affiliations 1 School of Textiles and Fashion, Shanghai University of Engineering Science, Shanghai 201620, PR China; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China. 2 School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, PR China. 3 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China. 4 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, PR China. Electronic address: chensy@dhu.edu.cn. 5 Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201620, PR China. Electronic address: song.gu@shgh.cn. 6 School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, PR China. Electronic address: baoxiu.wang@mail.dhu.edu.cn.)

出处: International journal of biological macromolecules 2024

关键词: Anti-cell adhesion;Antibacterial activity;Bacterial cellulose;Wound dressing.

摘要: Hydrogel-based wound dressings are becoming increasingly important for wound healing. Bacterial cellulose (BC) has been commonly used as wound dressin ...

作者: Fei Shi  1, Guiyun Zhang  1, Jinshi Li  2, Liang Shu  3, Cong Yu  4, Dabin Ren  4, Yisong Zhang  4, Ping Zheng  4 (Affiliations 1 Department of Neurovascular Intervention and Neurosurgery, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China. 2 Department of Neurology, Shanghai Pudong New area People's Hospital, Shanghai, China. 3 Department of Neurology, Shanghai Ninth People's Hospital, Shanghai, China. 4 Department of Neurosurgery, Shanghai Pudong New area People's Hospital, Shanghai, China.)

出处: CNS neuroscience & therapeutics 2024

关键词: LDHB;Mendelian randomization;causal effect;ischemic stroke.

摘要: Aims: Despite the success of single-cell RNA sequencing in identifying cellular heterogeneity in ischemic stroke, clarifying the mechanisms underlying ...

作者: Wei Du  1, Ying Li  1, Xufeng Wang  1, Sunzhe Xie  1, Hongfei Ci  1, Jiaming Zhou  1, Ningqi Zhu  1, Zule Chen  1, Yan Zheng  2, Huliang Jia  1   3 (Affiliations 1 Hepatobiliary Surgery, Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China. 2 Department of Pancreatic Surgery, Shanghai General Hospital, Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Cancer Metastasis Institute, Fudan University, Shanghai, China.)

出处: Cancer science 2024

关键词: ENO2;ceRNA;circESYT2;hepatocellular carcinoma progression;miR‐665.

摘要: Circular RNAs (circRNAs) have emerged as crucial regulators in tumor progression, yet their specific role in hepatocellular carcinoma (HCC) remains la ...

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