作者： Zhenzhen Wei;Ziyuan Wang;Qiong Chai;Zan Li;Mengjie Zhang;Yuli Zhang;Lu Zhang;Qingfeng Tang;Huirong Zhu;Hua Sui （Affiliations ¹ Medical Experiment Center, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201803, P.R. China. ² Department of Medical Oncology, Shuguang Hospital, Shanghai 201203, P.R. China. ³ Department of Pathology, Shuguang Hospital, Shanghai 201203, P.R. China. ⁴ Office of Academic Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China. ⁵ Department of Integrated Chinese and Western Medicine, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China.）

出处： Experimental and therapeutic medicine 2023

关键词： cancer stem cell;cetuximab;colorectal cancer;exosome;resistance.

摘要： The anti-EGFR antibody cetuximab is used as a first-line targeted therapeutic drug in colorectal cancer. It has previously been reported that the effi ...

作者： Li, Jing;Yang, Yang;Wang, Wenjing;Xu, Jiadai;Sun, Yifeng;Jiang, Jifeng;Tan, Hui;Ren, Liang;Wang, Yue;Ren, Yuhong;Zhang, Yian;Xu, Tianhong;Jia, Xuebing;Huang, Xiaoyun;Liu, Peng （¹Department of Hematology, Zhongshan Hospital, Fudan University ²Cancer Centre, Zhongshan Hospital, Fudan University ³Department of Nuclear Medicine, Zhongshan Hospital, Fudan University ⁴Institute of Nuclear Medicine, Fudan University, Shanghai Institute of Medical Imaging ⁵Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine ⁶Centre for Systems Biology, Intelliphecy）

出处： British Journal of Haematology 2023

关键词： immunotherapy;macrophage;multiple myeloma;single‐cell;tumour microenvironment

摘要： The tumour microenvironment (TME) plays a critical role in disease progression in multiple myeloma (MM). This study aimed to present an atlas of MM‐TM ...

作者： Ziting Lan;Xiaoying Ding;Yarong Yu;Lihua Yu;Wenli Yang;Xu Dai;Runjianya Ling;Yufan Wang;Wenyi Yang;Jiayin Zhang （Affiliations ¹ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, 200080, China. ² Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, China. ³ Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai, China. ⁴ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, China. wenyi.yang@shgh.cn. ⁵ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, 200080, China. andrewssmu@msn.com.）

出处： Cardiovascular diabetology 2023

关键词： Coronary computed tomography angiography;Diabetes;Fractional flow reserve;High-risk plaque.

摘要： Objectives: To investigate the prognostic value of computed tomography fractional flow reserve (CT-FFR) in patients with diabetes and to establish a r ...

作者： Xiaohu Tang;|Zhiyan Liu;|Jingwen Ren;|Ying Cao;|Shujie Xia;|Zhaolin Sun & Guangheng Luo （¹Medical College, Guizhou University, Guiyang, 550025, Guizhou, China;²Department of Urology Surgery, Guizhou Province People’s Hospital, Guiyang, 550002, China;³Guizhou Medical University, GuiyangGuizhou, 550025, China;⁴Department of Urology Surgery, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, 201620, China）

出处： Molecular and Cellular Biochemistry 2023

关键词： RNA-seq;BPH;BOO;Testosterone;Estradiol

摘要： In ageing men, benign prostatic hyperplasia (BPH) is a chronic disease that leads to progressive lower urinary tract symptoms (LUTS) caused by obstruc ...

作者： Desheng Chen;|Qi Zhu;|Tiewen Li;|Xuhui Fan;|Yichao Lou;|Yi Zhang;|Kejie Huang;|Hongcheng Sun （Affiliations ¹ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Institution for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ College of Information Science Electronic Engineering, Zhejiang University, Hangzhou, China.）

出处： Frontiers in genetics 2023

关键词： KLF4;biomarker;hepatocellular carcinoma;immune microenvironment;prognosis.

摘要： Introduction: Although the molecular mechanisms of Krüpple-like factor 4 (KLF4) as a tumor suppressor in HCC tumorigenesis have been thoroughly examin ...

作者： Yahui Zhang;|Yi Lin;|Guoqiang Li;|Yuan Yuan;|Xuejiao Wang;|Na Li;|Chuanhao Xiong;|Yueying Yang;|Yuhang Ma;|Zhijian Zhang;|Xiaoying Ding （Affiliations ¹ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. ³ Department of Neurology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Biology of reproduction 2023

关键词： Browning;GLP-1 receptor agonists (GLP-1RAs);Hyperandrogenemia;Hyperinsulinemia;Inflammation;Polycystic ovary syndrome (PCOS).

摘要： Polycystic ovary syndrome (PCOS) is a complicated hormonal and metabolic disorder with hyperandrogenemia, insulin resistance and reproductive dysfunct ...

作者： Kaidi Xiang;Jun Chen;Wenchen Zhao;Zhuoting Zhu;Li Ding;Gabriella Bulloch;Linlin Du;Xun Xu;Mengjun Zhu;Xiangui He （Affiliations ¹ Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Jiao Tong University, Shanghai, China. ³ Ophthalmology, Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.）

出处： Acta ophthalmologica 2023

摘要： Purpose: To determine how orthokeratology (ortho-k) affects corneal biomechanical properties in myopia control and whether corneal biomechanical param ...

作者： Yuwei Wang;Yuhong Chen;Jian Liang;Mei Jiang;Ting Zhang;Xiaoling Wan;Jiahui Wu;Xiaomeng Li;Jieqiong Chen;Junran Sun;Yifan Hu;Peirong Huang;Jingyang Feng;Te Liu;Xiaodong Sun （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ² Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China. ³ Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, China. ⁴ National Clinical Research Center for Eye Diseases, Shanghai 200080, China. ⁵ Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China.）

出处： Journal of molecular cell biology 2023

关键词： HMGA2;METTL3;N6-methyladenosine;epithelial–mesenchymal transition;subretinal fibrosis.

摘要： Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration (nAMD). Myofibroblast ...

作者： Changjiang Gu ^{#  1}, Fanqi Kong ^{#  1}, Junkai Zeng ^{#  1}, Xiangwu Geng  ¹, Yanqing Sun  ², Xiongsheng Chen  ^{3   4} （Affiliations ¹ Spine Center, Department of Orthopaedics, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200003, People's Republic of China. ² Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, 200080, Shanghai, PR China. syq04281226@126.com. ³ Spine Center, Department of Orthopaedics, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200003, People's Republic of China. chenxiongsheng@vip.sohu.com. ⁴ Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, 200080, Shanghai, PR China. chenxiongsheng@vip.sohu.com.）

出处： Cell & bioscience 2023

关键词： Ischemia reperfusion injury;Oxidative stress;RIPC;SIRT3.

摘要： Background: To study the protective effects of delayed remote ischemic preconditioning (RIPC) against spinal cord ischemia-reperfusion injury (SCIRI) ...

作者： J G Hong （Affiliation ¹ Department of Pediatrics, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.）

出处： Zhonghua er ke za zhi = Chinese journal of pediatrics 2023

摘要： 喘息是6岁以下儿童常见的呼吸道症状，导致儿童喘息原因多样，年龄越小喘息的病因越复杂，要重视儿童喘息的病因分析，以免延误诊断。早期采用抗炎为主的干预措施有益于气道炎症相关性喘息症状的改善，但需及时评估干预效应，避免过度用药。.