作者： Yihan Wang  ¹, Shunxiang Li  ¹, Tong Li  ², Jiao Wu  ¹, Yida Huang  ¹, Wanshan Liu  ¹, Chunmeng Ding  ¹, Lin Huang  ¹, Xiaoyu Xu  ¹, Yuning Wang  ¹, Sai Gu  ³, Kun Liu  ⁴, Kun Qian  ¹, Xiaodong Sun  ⁴ （Affiliations ¹ State Key Laboratory for Oncogenes and Related Genes, School of Biomedical Engineering, Institute of Medical Robotics and Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, 200030, P. R. China. ² Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai Gene Therapy Center, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China. ³ Department of Chemical Engineering, The University of Warwick, Coventry, CV4 8UW, UK. ⁴ Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai Gene Therapy Center, Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200040, P. R. China.）

出处： Small (Weinheim an der Bergstrasse, Germany) 2025

关键词： diabetic retinopathy;dual body fluids;metabolic fingerprint;vitreous liquid.

摘要： Diabetic retinopathy (DR) is a microvascular complication of diabetes, affecting 34.6% of diabetes patients worldwide. Early detection and timely trea ...

作者： Chaoxiang Du  ^{1   2}, Yunfan Hu  ¹, Xinyu Yang  ¹, Zhe Zhang  ³, Jianmin Gu  ^{1   4}, Tao Zhang  ², Renfeng Wang  ², Shaoyuan Zhang  ¹, Lijie Tan  ¹, Guiping Yu  ³ （Affiliations ¹ Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, 200032 Shanghai, China. ² Department of Thoracic Surgery, Zhongshan Hospital (Xiamen), Fudan University, 361006 Xiamen, Fujian, China. ³ Department of Cardiothoracic Surgery, The Affiliated Jiangyin Hospital of Nantong University, 214400 Jiangyin, Jiangsu, China. ⁴ Department of Vascular Surgery, General Surgery Clinical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.）

出处： Frontiers in bioscience (Landmark edition) 2025

关键词： NF-κB;SENP5;SLC1A3;oesophageal squamous cell carcinoma.

摘要： Background: This study investigates the role of small ubiquitin-like modifier (SUMO)-specific peptidase 5 (SENP5), a key regulator of SUMOylation, in ...

作者： Wei Gong ^{#  1   2}, Bo Zhang ^{#  1}, Dengji Zhou  ³, Saiguang Ling  ³, Jinliuxing Yang  ¹, Jun Chen  ¹, Jingjing Wang  ¹, Xun Xu  ^{1   2}, Xiangui He  ^{4   5}, Wei Gao  ⁶ （Affiliations ¹ Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongii University, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. ³ EVision technology (Beijing) co. LTD., Beijing, China. ⁴ Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongii University, Shanghai, China. xianhezi@163.com. ⁵ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. xianhezi@163.com. ⁶ Shanghai Eye Diseases Prevention &Treatment Center/ Shanghai Eye Hospital, School of Medicine, Tongii University, Shanghai, China. gaowei1108@hotmail.com.）

出处： Eye (London, England) 2025

摘要： Objectives: To identify the role of fundus vascular arcades angle (VAA) in reflecting choroidal thickness (ChT) of highly myopic children and adolesce ...

作者： Xinjuan Zhang  ^{1   2   3   4}, Cunxiu Fan  ^{5   1}, Yanqiu Liu  ⁶, Cunhua Zhao  ⁷, Yuhua Zhao  ⁸, Wu Yin  ⁹, Jianzhong Lin  ¹⁰, Jiaxing Zhang  ¹ （Affiliations ¹ Institute of Brain Disease and Cognition, School of Medicine, Xiamen University, 4221 Xiang'an South Road, Xiamen 361102, China. ² School of Education and Psychology, Minnan Normal University, 36 Xianqianzhi Street, Zhangzhou 363000, China. ³ Institute of Applied Psychology, Minnan Normal University, 36 Xianqianzhi Street, Zhangzhou 363000, China. ⁴ Fujian Province Key Laboratory of Applied Cognition and Personality, Minnan Normal University, 36 Xianqianzhi Street, Zhangzhou 363000, China. ⁵ Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai 201803, P.R. China. ⁶ Physical Education Institute, Jimei University, No. 185 Yinjiang Road, Jimei District, Xiamen 361021, China. ⁷ School of Medicine, Tibet University, No. 1, Norbulingka North Road, Chengguan District, Lhasa, Tibet Autonomous Region 850000, China. ⁸ Institute of High Altitude Medicine, Tibet Autonomous Region People's Hospital, No. 18, Linguo North Road, Chengguan District, Lhasa, Tibet Autonomous Region 850013, China. ⁹ Department of Radiology, Tibet Autonomous Region People's Hospital, No. 18, Linguo North Road, Chengguan District, Lhasa, Tibet Autonomous Region 850013, China. ¹⁰ Department of Radiology, Zhongshan Hospital of Xiamen University, School of Medicine, 201-209 Hubin South Road, Xiamen 361004, China.）

出处： Cerebral cortex (New York, N.Y. : 1991) 2025

关键词： MRI;Tibetans;brain;gender differences;high altitude.

摘要： Gender differences in adaptation to high-altitude environments are evident, but the specific patterns in Tibetan brains remain unclear. We analyzed T1 ...

作者： Xin Han  ¹, Chenjun Lv  ² （Affiliations ¹ Pathology Center, Shanghai General Hospital, 85 Wujin Road, Shanghai, 200080, China. ² Pathology Center, Shanghai General Hospital, 85 Wujin Road, Shanghai, 200080, China. chenjun.lv@outlook.com.）

出处： Discover oncology 2025

关键词： Cell migration;Cell proliferation;JAK/STAT pathway;MiRNA-21;Prostate cancer.

摘要： This research explored the role of microRNA (miRNA)-21 in prostate cancer (PCa) cells, as well as its regulation of the JAK/STAT pathway in PCa cells. ...

作者： Ziting Lan ^{#  1}, Xiaoying Ding ^{#  2}, Wenli Yang  ¹, Jiajun Yuan  ¹, Yarong Yu  ¹, Lihua Yu  ¹, Xu Dai  ¹, Yufan Wang  ³, Jiayin Zhang  ^{4   5} （Affiliations ¹ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yyffwang@sina.com. ⁴ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. andrewssmu@msn.com. ⁵ Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. andrewssmu@msn.com.）

出处： European radiology 2025

关键词： Atherosclerosis;Computed tomography angiography;Coronary;Diabetes mellitus;Lipoprotein (a).

摘要： Objectives: To explore the association between baseline Lp (a) levels and high-risk plaques, plaque volume, and plaque progression in patients with di ...

作者： Ningyao Cao ^{#  1   2}, Lili Feng ^{#  1   2}, Wei Xu ^{#  3}, Fanglin He ^{#  1   2}, Caiwen Xiao  ^{1   2}, Yan Liu  ^{1   2}, Weirong Xu  ⁴, Jingjing Cui  ⁴, Yuqian Guo  ⁵, Lianqing Yao  ⁶, Wenwen Xia  ⁷, Fei Chen ^{#  8}, Yong Li ^{#  9}, Chuandi Zhou ^{#  10   11   12}, Xiaofang Xu ^{#  13   14} （Affiliations ¹ Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China. ² Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. ³ Department of Cooperation and Exchange, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Anesthesiology and Operating Room, The Ninth People's Hospital of Shanghai, Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China. ⁵ Department of General Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Ophthalmology & Otolaryngology, Qiaojia County Traditional Chinese Medicine Hospital, Zhaotong, Yunnan, China. ⁷ Department of Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁸ Department of Anesthesiology and Operating Room, The Ninth People's Hospital of Shanghai, Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China. CHENF2106@sh9hospital.org.cn. ⁹ Department of Ophthalmology, The Calmette Affiliated Hospital of Kunming Medical University, No. 1228 Beijing Road, Panlong District, Kunming, 650021, Yunnan, China. liyong@kmmu.edu.cn. ¹⁰ Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China. chuandi.zhou@shgh.cn. ¹¹ Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. chuandi.zhou@shgh.cn. ¹² Innovative Research Team of High-Level Local Universities in Shanghai, Shanghai, China. chuandi.zhou@shgh.cn. ¹³ Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Road, Shanghai, 200011, China. xuxu0139@hotmail.com. ¹⁴ Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. xuxu0139@hotmail.com.）

出处： International journal of retina and vitreous 2025

关键词： Cross-sectional study;Diabetes;Diabetic retinopathy;Tear glucose.

摘要： Purpose: To examine the association between tear glucose (TG) and the presence and severity of diabetic retinopathy (DR) in patients with type 2 diabe ...

作者： Siyu Han ^{#  1}, Shiyu Zhao ^{#  1}, Ran Zhong ^{#  1}, Heyang Liu  ¹, Li Liu  ², Yongji Yan  ³ （Affiliations ¹ Department of Urology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100000, China. ² Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200000, China. ³ Department of Urology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100000, China. yyjdzm@163.com.）

出处： Urolithiasis 2025

关键词： Burden of disease;Disability-adjusted life-years;Incidence;Mortality;Urolithiasis.

摘要： This report analyzes the patterns of urolithiasis in China, India, the United States, and globally from 1990 to 2021 using data from the Global Burden ...

作者： Lin Peng  ¹, Yuhe Liu  ², Wenqian Wu  ², Yong Zhou  ³, Xin Huang  ⁴ （Affiliations ¹ Department of Dermatology, Hair Medical Center of Shanghai Tongji Hospital, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China. ² Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.85 Wujin Road, Shanghai, 200080, China. ³ Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.85 Wujin Road, Shanghai, 200080, China. yongzhou78214@163.com. ⁴ Department of Dermatology, Hair Medical Center of Shanghai Tongji Hospital, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, China. alida_huang@163.com.）

出处： BMC public health 2025

关键词： Community-based study;Diet;Female androgenetic alopecia;Lifestyle;Prevalence.

摘要： Background: To explore unhealthy diet and lifestyle factors associated with female androgenetic alopecia (FAGA) in a community-based study. Methods: A ...

作者： Di Pan  ^{1   2}, Xiaoling Dai  ³, Pan Li  ⁴, Luan Xue  ¹ （Affiliations ¹ Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China. ² Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. ³ Shanghai Putuo Traditional Chinese Medicine Hospital, Shanghai, People's Republic of China. ⁴ Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.）

出处： International journal of chronic obstructive pulmonary disease 2025

关键词： Mendelian randomization;ankylosing spondylitis;causal relationship;chronic obstructive pulmonary disease.

摘要： Background: Previous studies have found an association between ankylosing spondylitis (AS) and chronic obstructive pulmonary disease (COPD); however, ...