作者： Zhiyan Zhan  ^{1   2}, Jiarong Zhang  ³, Huisheng Liang  ⁴, Chong Wang  ⁵, Li Hong  ^{1   2}, Wenxue Liu  ³ （Affiliations ¹ Department of Clinical Nutrition, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. ² Clinical Research Center, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. ³ Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. ⁴ Department of Gynecology, Zhongshan Hospital, Fudan University (Xiamen Branch), Xiamen, 361000, China. ⁵ Department of Obstetrics and Gynecology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, 85 Wujin Road, Shanghai, 200080, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024

关键词： APEX1;KAT6A;PARP1 trapping;liquid‐liquid phase separation;ovarian cancer.

摘要： Most clinical PARP inhibitors (PARPis) trap PARP1 in a chromatin-bound state, leading to PARPi-mediated cytotoxicity. PARPi resistance impedes the tre ...

作者： Lihua Yu ^{#  1}, Yarong Yu ^{#  1}, Meiling Li  ¹, Runjianya Ling  ², Yuehua Li  ², Ai Wang  ³, Xifu Wang  ³, Yanli Song  ⁴, Xiao Zhang  ⁵, Pei Dong  ⁴, Yiqiang Zhan  ⁴, Dijia Wu  ⁴, Jiayin Zhang  ⁶ （Affiliations ¹ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, 200080, China. ² Institute of Diagnostic and Interventional Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, #600, Yishan Rd, Shanghai, China. ³ Department of Radiology, Shanghai General Hospital, Jiading Branch, #800, Huangjiahuayuan Rd, Shanghai, China. ⁴ Shanghai United Imaging Intelligence Co., Ltd, #2879 Longteng Ave, Shanghai, China. ⁵ School of Information Science and Technology, Northwest University, Xi'an, China. ⁶ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, 200080, China. andrewssmu@msn.com.）

出处： La Radiologia medica 2024

关键词： Artificial intelligence;Bypass graft;Coronary anomaly;Coronary computed tomography angiography;Stent.

摘要： Purpose: To develop and validate a deep learning (DL)-model for automatic reconstruction for coronary CT angiography (CCTA) in patients with origin an ...

作者： Juanjuan Li  ^{1   2   3   4}, Yinghong Zheng  ¹, Zhenzhen Duan  ², Qingye Zeng  ⁵, Jin Qu  ⁶, Jincheng Zhang  ², Jiao Liu  ¹, Wenlong Shang  ¹, Xixi Tao  ¹, Tingting Yu  ¹, Xinzhi Li  ⁷, Lifu Wang  ⁴, Liming Yang  ⁸, Deping Kong  ², Ying Yu  ¹ （Affiliations ¹ Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. ² Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai, China. ⁴ Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ⁶ Department of Vascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau, China. ⁸ Department of Pathophysiology, Key Laboratory of Cardiovascular Pathophysiology, Harbin Medical University, Harbin, China.）

出处： Hepatology (Baltimore, Md.) 2024

摘要： Background and aims: The liver possesses a remarkable regenerative capacity in response to injuries or viral infections. Various growth factors and cy ...

作者： Lingling Zhao  ^{1   2}, Minqiang Du  ², Ruihong Zhang  ^{2   3} （Affiliations ¹ Shanghai Bangde College, Shanghai, China. ² Shanghai First People's Hospital, Shanghai, China. ³ Affiliated Clinic of Luliang, Normal University, Luliang, China.）

出处： The Journal of international medical research 2024

关键词： Voluntary wheel running;chronic stress;depression;kynurenic acid;kynurenine metabolism;quinolinic acid.

摘要： Objective: To observe the effects of 4 weeks of voluntary wheel running on depressive-like behavior in a rat chronic stress-induced depression model t ...

作者： Haifeng Zhang  ^{1   2}, Gaoran Ge  ¹, Wei Zhang  ¹, Houyi Sun  ³, Xiaolong Liang  ¹, Yu Xia  ¹, Jiacheng Du  ⁴, Zerui Wu  ^{1   5}, Jiaxiang Bai  ^{1   6}, Huilin Yang  ¹, Xing Yang  ⁷, Jun Zhou  ¹, Yaozeng Xu  ¹, Dechun Geng  ¹ （Affiliations ¹ Department of Orthopedics Surgery, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China. ² Department of Orthopaedic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, 250063, China. ⁴ Department of Biochemistry and Molecular Biology, Jeonbuk National University Medical School, Jeonju, Jeonbuk, 54896, South Korea. ⁵ Department of Orthopedics, Changshu Hospital Affiliated to Soochow University, Changshu, Jiangsu, 215501, China. ⁶ Department of Orthopedics, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 234000, China. ⁷ Orthopedics and Sports Medicine Center, Suzhou Municipal Hospital, Nanjing Medical University Affiliated Suzhou Hospital, 242, Guangji Road, Suzhou, Jiangsu, 215008, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024

关键词： PP2Ac;ULK1;autophagy;dephosphorylation;mTORC1;osteoclastogenesis.

摘要： The molecular mechanism underlying abnormal osteoclastogenesis triggering subchondral bone remodeling in osteoarthritis (OA) is still unclear. Here, s ...

作者： Yun Xie¹CA1;Ruilan Wang¹CA2 （¹Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, Shanghai 201600, PR China）

出处： The American Journal of Emergency Medicine 2024

作者： Jinyan Kai  ¹, Haitao Huang  ², Jiaqi Su  ¹, Qiong Chen  ³ （Affiliations ¹ Department of Clinical Medical Laboratory, The Affiliated Second Hospital of Xiamen Medical College, Xiamen, Fujian, China. ² Department of Microbiology, Guilin Medical University, Guilin, Guangxi, China. ³ Department of Traditional Chinese Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.）

出处： Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024

关键词： bioinformatics;dermatomyositis;differentially expressed genes;nasopharyngeal carcinoma.

摘要： Background: Dermatomyositis (DM) is a kind of dermatologically associated autoimmune disease that is notably associated with an increased risk of conc ...

作者： Haihua Huang  ¹, Yuchen Wang  ², Jun Zeng  ³, Yanxue Ma  ⁴, Zelin Cui  ⁵, Yongxin Zhou  ⁶, Zheng Ruan  ² （Affiliations ¹ Department of thoracic surgery, Tongji Hospital Affiliated to Tongji University, 389，Xincun Road,Putuo District,Shanghai 200065,China, Shanghai, Shanghai, 200065, CHINA. ² Department of Thoracic Surgery, Shanghai General Hospital, 650，New Songjiang Road,Songjiang District,,Shanghai 201620,China, Shanghai, Shanghai, 200080, CHINA. ³ College of Textiles, Donghua University, Shanghai 201620, China, Donghua University, 2099 North Renmin Road,Shanghai,201620,China, Shanghai, 201620, CHINA. ⁴ College of Textiles, Donghua University, 2999 North Renmin Road,Shanghai,201620,China, Shanghai, 201620, CHINA. ⁵ Department of Laboratory Medicine, Shanghai General Hospital, 650，New Songjiang Road,Songjiang District,,Shanghai 201620,China, Shanghai, 200080, CHINA. ⁶ Department of Thoracic Surgery, Tongji Hospital Affiliated to Tongji University, 389，Xincun Road,Putuo District,Shanghai 200065,China, Shanghai, Shanghai, 200065, CHINA.）

出处： Biomedical materials (Bristol, England) 2024

关键词： bacterial degradation;biocompatibility;mechanical properties;polydioxanone weaving tracheal stent.

摘要： The appropriate degradation characteristics of polydioxanone (PDO) are necessary for the safety and effectiveness of stents. This study aimed to inves ...

作者： Mostafa Saeedinia  ¹, Jiayi Chen  ², Omid Kohandel Gargari  ³, Kyana Jafarabady  ⁴, Majid Zaki-Dizaji  ⁵, Alireza Ghorbankhanloo  ⁶, Zohreh Heidary  ⁷ （Affiliations ¹ Shahid Beheshti University of Medical Sciences, Tehran, Iran. mostafasaeediniya627@gmail.com. ² Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai 201803, P.R.China. 191537044@qq.com. ³ Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. kohandelgargar@gmail.com. ⁴ Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran. kyanajafarabady99@gmail.com. ⁵ Human Genetics Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. mz_dizaji@yahoo.com. ⁶ Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. alirezaghorbankhanloo@gmail.com. ⁷ Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran. zheidary2016@gmail.com.）

出处： Cellular and molecular biology (Noisy-le-Grand, France) 2024

摘要： Vitrification has important application in assisted reproductive technology (ART) and this technique has been widely used in the cryopreservation of o ...

作者： Xi Chen  ¹, Hengyu Mao  ¹, Feng Peng  ², Jiang Fan  ¹, Fu Yang  ¹ （Affiliations ¹ Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： The journal of gene medicine 2024

关键词： co‐delivery;docetaxel;esophageal cancer;nanoliposome;oridonin.

摘要： Introduction: Esophageal cancer is one of the major cancers in China. Most patients with esophageal cancer are diagnosed at an advanced stage, and the ...