作者： Shaojian Lin  ^{1   2   3}, Liangbo Wang  ², Changxi Han  ¹, Yuting Dai  ⁴, Changsheng Li  ¹, Yanting Liu  ¹, Bo Zhang  ¹, Ning Huang  ², Anke Zhang  ⁵, Tao Zhang  ², Yu Wang  ⁶, Jing Xie  ⁷, Hao Tang  ¹, Yijun Cheng  ¹, Hong Yao  ¹, Meiqing Lou  ⁸, Li Xue  ^{1   3}, Zhe Bao Wu  ^{1   2   3} （Affiliations ¹ Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. ³ Department of Neurosurgery, Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. ⁶ Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁸ Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Neuro-oncology 2024

关键词： Cabergoline;Gαq/PLC/PKC-γ;HTR2B;Pituitary adenomas;STAT3.

摘要： Background: Managing non-functioning pituitary adenomas (NFPAs) is difficult due to limited drug treatments. Cabergoline's (CAB) effectiveness for NFP ...

作者： Zheng Chen¹;Mincheng Yu¹;Bo Zhang¹;Lei Jin¹;Qiang Yu¹;Shuang Liu²;Binghai Zhou³;Jiuliang Yan⁴;Wentao Zhang¹;Xiaoqiang Li⁵;Yongfeng Xu¹;Yongsheng Xiao¹;Jian Zhou¹;Jia Fan¹;Mien-Chie Hung⁶CA;Qinghai Ye¹CA;Hui Li⁷CA;Lei Guo¹CA （¹a Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China;²b Neurosurgery Department of Zhongshan Hospital, Fudan University, Shanghai, P.R. China;³c Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, P.R. China;⁴d Department of Pancreatic Surgery, Shanghai General Hospital and Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China;⁵e Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, P.R. China;⁶f Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung, TX, Taiwan;g Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;⁷a Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China;h Shanghai Medical College and Zhongshan Hospital Immunotherapy Translational Research Center, Shanghai, P.R. China）

出处： OncoImmunology 2024

关键词： Immune checkpoints;immune evasion;liver cancer;survival signaling;tumor microenvironment

摘要： Functional roles of SIGLEC15 in hepatocellular carcinoma (HCC) were not clear, which was recently found to be an immune inhibitor with similar structu ...

作者： Kankan Zhao  ¹, Yanjie Zhu  ², Xiuyu Chen  ³, Shujuan Yang  ³, Weipeng Yan  ³, Kai Yang  ³, Yanyan Song  ³, Chen Cui  ³, Xi Xu  ³, Qingyong Zhu  ², Zhuo-Xu Cui  ², Gang Yin  ³, Huaibin Cheng  ², Minjie Lu  ², Dong Liang  ², Ke Shi  ⁴, Lei Zhao  ⁵, Hui Liu  ⁶, Jiayin Zhang  ⁷, Liang Chen  ³, Sanjay K Prasad  ⁸, Shihua Zhao  ⁹, Hairong Zheng  ¹⁰ （Affiliations ¹ Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China; Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Beijing, China. ² Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China. ³ State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ⁴ Department of Radiology, West China Hospital of Sichuan University, Chengdu, China. ⁵ Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. ⁶ Department of Radiology, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China. ⁷ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁸ Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial College, London, United Kingdom. ⁹ State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: cjrzhaoshihua2009@163.com. ¹⁰ Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China. Electronic address: hr.zheng@siat.ac.cn.）

出处： JACC. Cardiovascular imaging 2024

关键词： cardiac magnetic resonance;hypertrophic cardiomyopathy;machine learning;risk model.

摘要： Background: The cumulative burden of hypertrophic cardiomyopathy (HCM) is significant, with a noteworthy percentage (10%-15%) of patients with HCM per ...

作者： Xuan Lin  ¹, Zhengjie Dai  ², Yesiboli Tasiheng  ², Rulin Zhang  ³, Ruijie Wang  ², Jia Dong  ², Yusheng Chen  ², Mingjian Ma  ², Xuan Zou  ², Yu Yan  ², Xu Wang  ⁴, Xianjun Yu  ⁵, He Cheng  ⁶, Chen Liu  ⁷ （Affiliations ¹ Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China; Tissue Bank, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China. ² Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. ³ Department of Laboratory Medicine, Shanghai General Hospital, Shanghai, China. ⁴ Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China; Cancer Research Institute, Shanghai Key Laboratory of Radiation Oncology, Cancer Research Institute, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China. Electronic address: wangxu2013@fudan.edu.cn. ⁵ Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. Electronic address: yuxianjun@fudanpci.org. ⁶ Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. Electronic address: chenghe@fudanpci.org. ⁷ Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Pancreatic Cancer Institute, Shanghai 200032, China; Pancreatic Cancer Institute, Fudan University, Shanghai 200032, China. Electronic address: liuchen@fudanpci.org.）

出处： Biochimica et biophysica acta. Molecular basis of disease 2024

关键词： BCL6;Cell therapy;Chimeric antigen receptor;Follicular helper T cells;Pancreatic ductal adenocarcinoma.

摘要： PDAC is a typical 'cold tumor' characterized by low immune cell infiltration and a suppressive immune microenvironment. We previously observed the exi ...

作者： Xin Luo  ¹, Lun-Gen Lu  ¹ （Affiliation ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Journal of clinical and translational hepatology 2024

关键词： Cholestatic liver disease;Management;Obeticholic acid;Primary biliary Cholangitis;Primary sclerosing cholangitis;Ursodeoxycholic acid.

摘要： Cholestatic liver disease is a group of diseases in which bile acid accumulates in the liver for various reasons, resulting in abnormal liver biochemi ...

作者： Jiajun Yuan ^{#  1}, Xiaoying Ding ^{#  2}, Wenli Yang  ¹, Ziting Lan  ¹, Yarong Yu  ¹, Lihua Yu  ¹, Xu Dai  ¹, Yufan Wang  ³, Jiayin Zhang  ⁴ （Affiliations ¹ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, China. ² Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, China. ³ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, China. yyffwang@sina.com. ⁴ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, China. andrewssmu@msn.com.）

出处： European radiology 2024

关键词： Atherosclerosis;Computed tomography angiography;Diabetes mellitus;Fibrosis;Myocardial perfusion imaging.

摘要： Objectives: We aimed to explore the imaging profile of coronary atherosclerosis, perivascular inflammation, myocardial perfusion, and interstitial fib ...

作者： Wenbin Gong  ¹, Hangyu Fu  ¹, Kui Yang  ¹, Tao Zheng  ², Kun Guo  ³, Wei Zhao  ¹ （Affiliations ¹ Department of General Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. ² Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of General Surgery, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.）

出处： Cell proliferation 2024

摘要： GSDMB-mediated pyroptosis facilitates a pro-inflammatory immune microenvironment and needs to be tightly regulated to avoid excessive inflammation. He ...

作者： Caiqi Zhao  ^{1   2   3}, Mengyao Pan  ^{1   3}, Jie Chen  ^{1   3}, Ling Li  ^{1   3}, Yan Zhang  ⁴, Wenjun Liu  ⁵, Michael A Matthay  ⁶, Haichao Wang  ⁷, Xia Jin  ⁸, Jin-Fu Xu  ², Xiao Su  ^{1   3} （Affiliations ¹ Unit of Respiratory Infection and Immunity, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. ² Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. ³ University of Chinese Academy of Sciences, Beijing, China. ⁴ Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. ⁶ Department of Medicine, Department of Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA. ⁷ Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York, USA. ⁸ Shanghai Serum Bio-Technology Co., Ltd., Shanghai, China.）

出处： Journal of medical virology 2024

关键词： ASK1;NEDD4L;PTP1B;influenza A virus;p38MAPK;α7 nAChR.

摘要： The vagus nerve circuit, operating through the alpha-7 nicotinic acetylcholine receptor (α7 nAChR), regulates the inflammatory response by influencing ...

作者： Shuxin Deng  ^{1   2}, Yuan Xu  ³, Antony R Warden  ^{1   2}, Li Xu  ^{1   2}, Xiaoqian Duan  ^{1   2}, Jie He  ^{1   2}, Kaiwen Bao  ^{1   2}, Runing Xiao  ^{1   2}, Mehmoona Azmat  ^{1   2}, Liao Hong  ⁴, Lai Jiang  ¹, Guangxia Shen  ^{1   2}, Zhenbo Zhang  ⁵, Xianting Ding  ^{1   2} （Affiliations ¹ Department of Anesthesiology and Surgical Intensive Care Unit, Xinhua Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China. ² State Key Laboratory of Systems Medicine for Cancer, Institute for Personalized Medicine, Shanghai Jiao Tong University, Shanghai 200030, China. ³ Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. ⁴ Department of Clinical Laboratory Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200092, China. ⁵ Reproductive Medicine Center, Department of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China.）

出处： Analytical chemistry 2024

摘要： An effective tool to assess embryo quality in the assisted reproduction clinical practice will enhance successful implantation rates and mitigate high ...

作者： Lijuan Huang  ¹, Honggai Yan  ², Yan Xie  ², Ningdong Li  ^{1   3} （Affiliations ¹ Department of Ophthalmology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China. ² Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, Beijing, China. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai, China.）

出处： Indian journal of ophthalmology 2024

摘要： Purpose: To evaluate the surgical outcomes for patients with superior oblique paralysis (SOP) who underwent the inferior oblique weakening and the gra ...