作者： Alasdair G Morgan  ^{1   2}, Michael J Thrippleton  ^{1   2}, Michael S Stringer  ^{1   2}, Francesca M Chappell  ^{1   2}, Maria C Valdés-Hernández  ^{1   2}, Stewart Wiseman  ^{1   2}, Lucia Ballerini  ³, Rosalind Brown  ^{1   2}, Yajun Cheng  ⁴, Xiaodi Liu  ⁵, Junfang Zhang  ⁶, Eleni Sakka  ^{1   2}, Daniela Jamie Garcia  ^{1   2}, Emilie Sleight  ^{1   2}, Cameron Manning  ^{1   2}, Roberto D Coello  ^{1   2}, Dominic Job  ^{1   2}, Angela Jochems  ^{1   2}, Carmen Arteaga  ^{1   2}, Una Clancy  ^{1   2}, Ian Marshall  ^{1   2}, Fergus N Doubal  ^{1   2}, Joanna M Wardlaw  ^{1   2} （Affiliations ¹ Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, The University of Edinburgh, United Kingdom (A.G.M., M.J.T., M.S.S., F.M.C., M.C.V.-H., S.W., R.B., E. Sakka, D.J.G., E. Sleight, C.M., R.D.C., D.J., A.J., C.A., U.C., I.M., F.N.D., J.M.W.). ² UK Dementia Research Institute at The University of Edinburgh, Edinburgh Medical School, United Kingdom (A.G.M., M.J.T., M.S.S., F.M.C., M.C.V.-H., S.W., R.B., E. Sakka, D.J.G., E. Sleight, C.M., R.D.C., D.J., A.J., C.A., U.C., I.M., F.N.D., J.M.W.). ³ University for Foreigners of Perugia, Italy (L.B.). ⁴ Department of Neurology, West China Hospital of Sichuan University (Y.C.). ⁵ Division of Neurology, Department of Medicine, The University of Hong Kong (X.L.). ⁶ Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China (J.Z.).）

出处： Stroke 2025

关键词： antihypertensive agents;brain ischemia;carotid artery, internal;extracellular fluid;stroke, lacunar.

摘要： Background: Cerebral small vessel disease (SVD) causes up to 45% of dementias and 25% of ischemic strokes, but the understanding of vascular pathophys ...

作者： Hui Wang¹;Zijian Wang¹;Jin Ma²;Jian Chen³;Hong Li¹;Weiju Hao¹;Qingyuan Bi¹;Shuning Xiao¹;Jinchen Fan¹CA1;Guisheng Li^1,2 （¹School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China;²Department of Chemistry, Shanghai Normal University, 100 Guilin Rd., Shanghai 200234, China;³Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China）

出处： Journal of Colloid and Interface Science 2025

摘要： As a kind of promising oxygen evolution reaction (OER) catalysts, metal–organic frameworks (MOF) are often constrained by their inherent poor electroc ...

作者： Xiao-Yu Wu^1,2;Shi Peng^1,2;Xin-Tao Li^3,2;Song-Wen Chen¹;Yong Wei¹;Yu-Tong Ye¹;Chang-Zuan Zhou¹;Zi-Kan Zhong¹;Long-Zhe Gao¹;Chen-Yang Jin¹;De-Ping Kong⁴;Shao-Wen Liu¹CA1;Gen-Qing Zhou¹CA2 （¹Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China;²These authors contributed equally to this work.;³Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China;⁴Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China）

出处： Biochimica et Biophysica Acta - Molecular Basis of Disease 2025

关键词： PFKP;Hypertrophy;Myocyte, cardiac;EIF2S2;Protein synthesis

摘要： Metabolic reprogramming precedes most alterations during pathological cardiac hypertrophy and heart failure (HF). Recent studies have revealed that Ph ...

作者： Kainan Guo¹;Kangkang Ou¹CA1;Md All Amin Newton¹;Jun Zhang¹;Hui Xu²;Jinyi Li¹;Binjie Xin¹CA2;Yinjun Huang³CA3 （¹School of Textiles and Fashion, Shanghai University of Engineering Science, Shanghai 201620, PR China;²Henan Key Laboratory of Medical and Protective Products, Xinxiang 453400, PR China;³Department of Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, PR China）

出处： Journal of Colloid and Interface Science 2025

摘要： Chronic wounds often produce a significant volume of exudate, posing a substantial obstacle to healing. Consequently, there is a pressing demand for a ...

作者： Zhong Chen^1,2;Da-Wei Geng²;Tang-Bo Yuan²;Chen Yu²;Da-Wei Cai²;Yong Yin³CA1;Qiang Shen¹CA2 （¹Department of Orthopaedics, Shanghai General Hospital of Nanjing Medical University, Shanghai, China;²Department of Orthopaedics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China;³Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China）

出处： Bioorganic & Medicinal Chemistry Letters 2025

摘要： Novel N-substituent diphenylamine derivatives as tubulin inhibitors targeting colchicine-binding site have been designed based on structural simplific ...

作者： Min Tang^1,2,3;Xiaohui Wei^1,3;Yunqin Ma^1,3;Yijiong Tan⁴;Han Cao^5,6;Shuangshuang Yao¹;Jiaqi Wang¹;Hua Yang²;Fang Liu¹;Yongde Peng^1,5CA1;Nengguang Fan¹CA2 （¹Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Department of Endocrinology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;³These authors contributed equally to this work.;⁴Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁵Department of Endocrinology and Metabolism, Shanghai General Hospital of Nanjing Medical University, Shanghai, China;⁶Department of Endocrinology, Songjiang District Central Hospital, Shanghai, China）

出处： Life Sciences 2025

摘要： Objective The role of ubiquitin-specific protease 13 (USP13) in metabolic dysfunction-associated steatohepatitis (MASH) remains unclear. This study ai ...

作者： Meng Gu  ¹, Jiajun Fang  ², Zhongmei Shao  ³, Hui Yu  ¹, Senchao Guo  ¹, Yang Gao  ¹, Xiaojin He  ⁴, Yuping Xu  ⁵, Mingrong Lv  ⁶ （Affiliations ¹ Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China. ² The First Clinical Medical College of Anhui Medical University, Hefei 230032, China. ³ Anhui No. 2 Provincial People's Hospital, Hefei, Anhui 230012, China. ⁴ NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address: allin0701@126.com. ⁶ Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address: lvmingrong2016@163.com.）

出处： Gene 2025

关键词： Assisted reproductive technology;ERCC6;FOXL2;Female infertility;Premature ovarian insufficiency.

摘要： Premature ovarian insufficiency (POI) is the main cause of infertility in women. Some cases of POI are thought to be caused by genetic defects and the ...

作者： Y. Hu^1,2;G. Zhou^3,2;S. Jiang⁴;L. Gao³;Y. Yu⁵;Q. Wang¹;J. Chen¹CA1;J. Zhang⁵CA2 （¹Department of Radiology, Dongtai People's Hospital, Kangfuxi Rd, Yancheng, China;²Dr. Y. Hu and Dr. G. Zhou contributed equally to this study.;³Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴Department of Clinical and Technical Support, Philips Healthcare, China;⁵Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, China）

出处： Clinical Radiology 2025

摘要： Aim To analyze epicardial adipose tissue (EAT) radiomics and assess the impact of risk factors on different types of atrial fibrillation (AF). Materia ...

作者： Lingxuan Zhu^1,2;Weiming Mou^1,3;Peng Luo² （¹Authors share first authorship.;²Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, China;³Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Clinical Gastroenterology and Hepatology 2025

作者： Yu Lv^1,2,3;Xia Wang^1,3;Youjie Zeng⁴;Zizhao Tang^1,5;Fangqin Nie^1,6;Ren Guo¹CA1 （¹Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China;²Department of Orthopaedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;³These authors contributed equally to this work.;⁴Department of Anesthesiology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China;⁵Department of Pharmacy, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;⁶Department of Pharmacy, Hospital/School Of Stomatology, Zunyi Medical University, Zunyi, Guizhou 563000, China）

出处： Tissue and Cell 2025

摘要： Introduction The phenotypic transition of vascular smooth muscle cells (VSMCs) from a quiescent, contractile type to a secretory phenotype with high p ...