作者： Mei Qi-Xiang  ^{1   2}, Fu Yang  ^{1   2}, Huang Ze-Hua  ^{1   2}, Yin Nuo-Ming  ², Wang Rui-Long  ², Xu Bin-Qiang  ², Fan Jun-Jie  ², Huang Chun-Lan  ², Zeng Yue  ² （Affiliations ¹ Shanghai Key Laboratory of Pancreatic Disease, Shanghai JiaoTong University School of Medicine, Shanghai, China. ² Department of Gastroenterology, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.）

出处： Gut microbes 2022

关键词： Acute pancreatitis;TLR4;gut microbiota;intestinal epithelium cells.

摘要： Toll-like receptor 4 (TLR4) has been identified as a potentially promising therapeutic target in acute pancreatitis (AP). However, the role of intesti ...

作者： Mengya Niu  ¹, Xiuli Zhang  ², Pengli Song  ², Liang Li  ², Li Wen  ³ （Affiliations ¹ Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China. ² Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. Electronic address: wenli7007@gmail.com.）

出处： Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2022

关键词： Infusion rate;Obstructive etiologies;Pancreatic intraductal pressure;Pancreatitis;Solution viscosity.

摘要： Background/objectives: Pancreatic intraductal pressure is related to the development of pancreatitis, including post-ERCP (endoscopic retrograde chola ...

作者： Shuyue Zhang  ¹, Xiuxiu Jiao  ^{1   2}, Michal Heger  ³, Shen Gao  ⁴, Mei He  ¹, Nan Xu  ¹, Jigang Zhang  ¹, Mingjian Zhang  ¹, Yuan Yu  ⁴, Baoyue Ding  ³, Xueying Ding  ¹ （Affiliations ¹ Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics, Department of Pharmaceutics, College of Medicine, Jiaxing University, Jiaxing, China. ⁴ Department of Pharmaceutical Science, School of Pharmacy, Naval Medical University, Shanghai, China.）

出处： Drug delivery 2022

关键词： Glioblastoma;chemo-radiotherapy;mic-roenvironment-responsive;radiosensitization;targeted nanotherapeutics.

摘要： Glioblastoma is rather recalcitrant to existing therapies and effective interventions are needed. Here we report a novel microenvironment-responsive m ...

作者： Yi Wang  ^{1   2}, Xinyu Zhang  ¹, Yinhao Chen  ¹, Bingye Zhu  ³, Qianwei Xing  ¹ （Affiliations ¹ Department of Urology, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, 226001, China. ² Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of Urology, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, Jiangsu Province, 226001, China.）

出处： Andrology 2022

关键词： Biomarkers;Cuproptosis;Diabetic erectile dysfunction;Ferroptosis;Immunity;m6A.

摘要： Background: Currently, patients with diabetes erectile dysfunction (DMED) were not satisfied with the effects of first-line phosphodiesterase types 5 ...

作者： Hao Chen ^{#  1}, Chunlin Li ^{#  2}, Haiyang Hu  ³, Bin Zhang  ⁴ （Affiliations ¹ Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, China. ² Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 201620, China. ³ Department of Vascular Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China. huhaiyang1988@163.com. ⁴ Department of Neurosurgery, Affiliated Hospital of Jining Medical University, Jining, China. zhangbin8515@163.com.）

出处： BMC molecular and cell biology 2022

关键词： Glioblastoma;Mitochondrial dysfunction;Oxidative stress;TRPA1;Temozolomide.

摘要： Background: Glioblastoma (GBM) represents nearly one-half of primary brain tumors, and the median survival of patients with GBM is only 14.6 months. S ...

作者： Zu-Yin Li  ¹, Gang Wu  ², Chen Qiu  ³, Zhi-Jie Zhou  ⁴, Yu-Peng Wang  ⁵, Guo-He Song  ⁵, Chao Xiao  ⁶, Xin Zhang  ⁷, Gui-Long Deng  ⁸, Rui-Tao Wang  ⁸, Yu-Long Yang  ⁹, Xiao-Liang Wang  ⁷ （Affiliations ¹ Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing 100034, China. ² Department of Gastrointestinal Surgery, Henan Provincial People's Hospital, Zhengzhou 450003, Henan Province, China. ³ Institute of Gallstone Disease, Shanghai East Hospital, Shanghai 200120, China. ⁴ Department of General Surgery, Huashan Hospital North, Shanghai 201907, China. ⁵ Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China. ⁶ Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200041, China. ⁷ Department of General Surgery, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China. ⁸ Department of General Surgery, Shanghai General Hospital, Shanghai 201600, China. ⁹ Institute of Gallstone Disease, Center of Gallbladder Disease, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.）

出处： World journal of gastroenterology 2022

关键词： Fatty acid metabolism;MK-4074;Nonalcoholic fatty liver disease;TM6SF2;Treatment.

摘要： Background: The lack of effective pharmacotherapies for nonalcoholic fatty liver disease (NAFLD) is mainly attributed to insufficient research on its ...

作者： Shuli Liang  ¹, Xing Fan  ², Feng Chen  ³, Yonghong Liu  ³, Binghui Qiu  ⁴, Kai Zhang  ⁵, Songtao Qi  ⁴, Guojun Zhang  ³, Jinfang Liu  ⁶, Jianguo Zhang  ², Jun Wang  ⁴, Xiu Wang  ⁵, Ziyang Song  ³, Guoming Luan  ⁷, Xuejun Yang  ⁸, Rongcai Jiang  ⁹, Hua Zhang  ¹⁰, Lei Wang  ⁵, Yongping You  ¹¹, Kai Shu  ¹², Xiaojie Lu  ¹³, Guoyi Gao  ¹⁴, Bo Zhang  ¹⁵, Jian Zhou  ⁷, Hai Jin  ¹⁶, Kaiwei Han  ¹⁷, Yiming Li  ¹⁷, Junji Wei  ¹⁸, Kun Yang  ¹⁹, Gan You  ⁵, Hongming Ji  ²⁰, Yuwu Jiang  ²¹, Yi Wang  ²², Zhiguo Lin  ²³, Yan Li  ²⁴, Xuewu Liu  ²⁵, Jie Hu  ²⁶, Junming Zhu  ²⁷, Wenling Li  ²⁸, Yongxin Wang  ²⁹, Dezhi Kang  ³⁰, Hua Feng  ³¹, Tinghong Liu  ³, Xin Chen  ⁹, Yawen Pan  ³², Zhixiong Liu  ⁶, Gang Li  ³³, Yunqian Li  ³⁴, Ming Ge  ³⁵, Xianming Fu  ³⁶, Yuping Wang  ³⁷, Dong Zhou  ³⁸, Shichuo Li  ³⁹, Tao Jiang  ⁴⁰, Lijun Hou  ⁴¹, Zhen Hong  ⁴² （Affiliations ¹ Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi Road, Xicheng District, Beijing 100045, China. ² Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. ³ Xijing Hospital of Airforce Medical University, Xi'an, China. ⁴ Nanfang Hospital, Southern Medical University, Guangzhou, China. ⁵ Beijing Tiantan Hospital, Capital Medical University, Beijing, China. ⁶ Xiangya Hospital, Central South University, Changsha, China. ⁷ Sanbo Brain Hospital, Capital Medical University, Beijing, China. ⁸ Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China. ⁹ Tianjin Medical University General Hospital, Tianjin, China. ¹⁰ Department of Neurosurgery, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China. ¹¹ Jiangsu Provincial People's Hospital, Nanjing, China. ¹² Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ¹³ The Affiliated Hospital, Jiangnan University, Wuxi, China. ¹⁴ Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. ¹⁵ Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China. ¹⁶ General Hospital of Northern Theater Command, Shenyang, China. ¹⁷ Shanghai Changzheng Hospital, Shanghai Neurosurgical Institute, Shanghai, China. ¹⁸ Peking Union Medical College Hospital, Beijing, China. ¹⁹ The First Affiliated Hospital, Hainan Medical University, Haikou, China. ²⁰ Shanxi Provincial People's Hospital, Taiyuan, China. ²¹ Peking University First Hospital, Beijing, China. ²² Children's Hospital of Fudan University, Shanghai, China. ²³ First Affiliated Hospital, Harbin Medical University, Harbin, China. ²⁴ Children's Hospital of Soochow University, Suzhou, China. ²⁵ Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China; Institute of Epilepsy, Shandong University, Jinan, China. ²⁶ Huashan Hospital, Fudan University, Shanghai, China. ²⁷ The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China. ²⁸ The Second Hospital of Hebei Medical University, Shijiazhuang, China. ²⁹ The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. ³⁰ The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. ³¹ The Southwest Hospital, Army Medical University, Chongqing, China. ³² Lanzhou University Second Hospital, Lanzhou, China. ³³ Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. ³⁴ The First Hospital of Jilin University, Changchun, China. ³⁵ Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; Key Laboratory of Major Disease in Children, Ministry of Education, Beijing, China. ³⁶ The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei, China. ³⁷ Xuanwu Hospital, Capital Medical University, Beijing, China. ³⁸ West China Hospital, Sichuan University, Chengdu, China. ³⁹ China Association Against Epilepsy, No. 135 Xizhimen Wai Avenue, Beijing 100044, China. ⁴⁰ Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Fengtai District, Beijing 10070, China. ⁴¹ Shanghai Changzheng Hospital, Shanghai Neurosurgical Institute, No. 415, Fengyan Road, Huangpu District, Shanghai 200003, China. ⁴² Huashan Hospital, Fudan University, No. 12, Urumqi Middle Road, Jing'an District, Shanghai 200044, China.）

出处： Therapeutic advances in neurological disorders 2022

关键词： anti-seizure medications (ASMs);craniocerebral surgery-related epilepsy;craniocerebral surgery-related seizure;guideline.

摘要： Seizures are a common symptom of craniocerebral diseases, and epilepsy is one of the comorbidities of craniocerebral diseases. However, how to rationa ...

作者： Congying Chen ^{#  1}, Ruling Zhang ^{#  1}, Rong Wan  ¹ （Affiliation ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.）

出处： Endoscopy 2022

作者： Chufeng Gu  ¹, Xinping She  ¹, Chuandi Zhou  ¹, Tong Su  ¹, Shuai He  ¹, Chunren Meng  ¹, Qing Gu  ¹, Dawei Luo  ¹, Zhi Zheng  ², Qinghua Qiu  ³ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, PR China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, PR China. Electronic address: zzheng88@sjtu.edu.cn. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, PR China; Department of Ophthalmology, Shigatse People's Hospital, Shigatse, Xizang, PR China. Electronic address: qinghuaqiu@163.com.）

出处： Pharmacological research 2022

作者： Menghan Li  ^{1   2}, Jiayi Yu  ^{1   2}, Qiuying Chen  ^{1   2}, Hao Zhou  ¹, Haidong Zou  ^{1   2}, Jiangnan He  ², Jianfeng Zhu  ², Ying Fan  ¹, Xun Xu  ^{1   2} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photo Medicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ² Department of Preventative Ophthalmology, Shanghai Eye Diseases Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai, China.）

出处： Acta ophthalmologica 2022

关键词： high myopia;myopic atrophy maculopathy;posterior scleral height;retinoschisis;vitreoretinal interface abnormality.

摘要： Purpose: To investigate the clinical characteristics, internal correlations and risk factors for different locations of retinoschisis (RS) in an elder ...