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[外文期刊] GSK-3β inhibition protects human nucleus pulposus cell against oxidative stress-inducing apoptosis through mitochondrial pathway
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作者: Kai Zhu #  1   2   3, Song Guo #  4, Guoyi Han  2, Xiancheng Qiang  5, Mengmeng Ma  3, Qinglei Xu  2, Wenjie Tang  6, Jun Tan  7 (Affiliations 1 Department of Orthopaedics, Shanghai East Hospital, Tongji University School of Medicine, No.150 Jimo Road, Shanghai, 200120, People\'s Republic of China. 2 Department of Orthopaedics II, Qingdao No.8 People\'s Hospital, No.84 Fengshan Road, Qingdao, 266121, People\'s Republic of China. 3 Research Center for Translational Medicine, Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, No.150 Jimo Road, Shanghai, 200120, People\'s Republic of China. 4 Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiaotong University, No.100 Haining Road, Shanghai, 200080, People\'s Republic of China. 5 Department of Anesthesiology, Qingdao No.8 People\'s Hospital, No. 84 Fengshan Road, Qingdao, 266121, People\'s Republic of China. 6 Research Center for Translational Medicine, Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, No.150 Jimo Road, Shanghai, 200120, People\'s Republic of China. 1701927@tongji.edu.cn. 7 Department of Orthopaedics, Shanghai East Hospital, Tongji University School of Medicine, No.150 Jimo Road, Shanghai, 200120, People\'s Republic of China. tanjuntj2012@163.com.)

出处: Molecular biology reports 2022

关键词: Apoptosis;GSK-3β;Intervertebral disc degeneration;Nucleus pulposus cells;Oxidative stress;SB216763.

摘要: Background: Oxidative stress in the intervertebral disc leads to nucleus pulposus (NP) degeneration by inducing cell apoptosis. However, the molecular ...

作者: Tao Wang #  1   2   3, Jiaxiang Bai #  4, Min Lu  1, Chenglong Huang  3, Dechun Geng  4, Gang Chen  3, Lei Wang  1, Jin Qi  5, Wenguo Cui  6, Lianfu Deng  7 (Affiliations 1 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. 2 Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, 200080, Shanghai, P. R. China. 3 Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, Department of Orthopaedics, The second Affiliated Hospital of Jiaxing University, 1518 North Huancheng Road, 314000, Jiaxing, P. R. China. 4 Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, P. R. China. 5 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. jinjin838@hotmail.com. 6 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. wgcui80@hotmail.com. 7 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. lf_deng@126.com.)

出处: Nature communications 2022 Vol.13 No.1 P160

摘要: Immune response and new tissue formation are important aspects of tissue repair. However, only a single aspect is generally considered in previous bio ...

[外文期刊] Identification of Active Bronchioalveolar Stem Cells as the Cell-of-Origin in Lung Adenocarcinoma
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作者: Huijing Yin  1, Bo Jing  2, Dongliang Xu  3, Wenzheng Guo  4, Beibei Sun  5, Jie Zhang  6, Yueling Liao  7, Hongyong Song  8, Tong Wang  2, Shuli Liu  9, Yanbin Kuang  10, Min Hu  2, Kaimi Li  2, Siwei Zhang  2, Hongjia Zhang  11, Jianhua Xu  12, Xue Li  13, Jing Du  14, Yadi Wu  15, Yingli Wu  16, Qi Wang  17, Feng Yao  18, Y Eugene Chin  19, Binhua P Zhou  20, Jiong Deng  21 (Affiliations 1 Oncology, Fudan University Shanghai Cancer Center. 2 Shanghai Jiao Tong University. 3 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. 4 Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine. 5 Translation Medicine Center, Shanghai Chest Hospital, Shanghai Jiao Tong University. 6 Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University. 7 Pathophysiology, Shanghai Jiao Tong University School of Medicine. 8 Department of Pathophysiology, Key laboratory of Cell Differentiation and Apoptosis of Minister of Education, Shanghai Jiao Tong University School of Medicine. 9 Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People\'s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. 10 Department of Respiratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University. 11 Shanghai Jiao Tong University School of Medicine. 12 Kunming Medical University. 13 Binzhou Medical University. 14 Center of Cancer Research, Binzhou Medical University Hospital. 15 University of Kentucky Medical Center. 16 Shanghai Jiao Tong University School of Medicine, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital / Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Different. 17 Respiratory Medicine, Second Affiliated Hospital of Dalian Medical University. 18 Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai. 19 IBMS, Soochow University Medical College, 199 Ren\'ai Road, Suzhou, Jiangsu Province, 215123, China. 20 Molecular and Cellular Biochemistry, University of Kentucky School of Medicine. 21 Pathophysiology, Shanghai Jiao Tong University School of Medicine jiongdeng@bzmc.edu.cn.)

出处: Cancer research 2022

摘要: While initiation is established as a critical step in tumorigenesis, the identity of the cell-of-origin for lung adenocarcinoma and the mechanism cont ...

[外文期刊] Autoantibodies Targeting AT 1 - and ET A -Receptors Link Endothelial Proliferation and Coagulation via Ets-1 Transcription Factor.
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作者: Catar, Rusan1,2;Herse-Naether, Melanie1,2;Zhu, Nan1,3;Wagner, Philine1,2;Wischnewski, Oskar1,2;Kusch, Angelika1,2,4;Kamhieh-Milz, Julian5;Eisenreich, Andreas6;Rauch, Ursula6;Hegner, Björn1,2,7;Heidecke, Harald8;Kill, Angela9,10;Riemekasten, Gabriela9,10,11;Kleinau, Gunnar12;Scheerer, Patrick12,13;Dragun, Duska1,2,4;Philippe, Aurelie1,2,4 (1 Department of Nephrology and Medical Intensive Care, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 2 Center for Cardiovascular Research, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 3 Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China 4 Berlin Institute of Health, Charité—Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, 10117 Berlin, Germany 5 Department of Transfusion Medicine, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 6 Department of Cardiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 7 Vitanas Klinik für Geriatrie, 13435 Berlin, Germany 8 CellTrend GmbH, 14943 Luckenwalde, Germany 9 Deutsches Rheuma-Forschungszentrum (DRFZ), A. Leibniz Institute, 10117 Berlin, Germany 10 Department of Rheumatology and Clinical Immunology, CCM, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 11 Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), 23845 Borstel, Germany 12 Group Protein X-ray Crystallography and Signal Transduction, Institute of Medical Physics and Biophysics, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 13 DZHK (Deutsches Zentrum für Herz-Kreislauf Forschung), Partner Site Berlin, 13353 Berlin, Germany)

出处: International Journal of Molecular Sciences 2022 Vol.23 No.1 P244

关键词: angiotensin;autoantibodies;coagulation;endothelin-1;renal crisis;renin–angiotensin system;systemic sclerosis

摘要: Scleroderma renal crisis (SRC) is an acute life-threatening manifestation of systemic sclerosis (SSc) caused by obliterative vasculopathy and thrombot ...

作者: Dashan Ai  1   2, Jinjun Ye  3, Shihong Wei  4, Yunhai Li  5, Hui Luo  6, Jianzhong Cao  7, Zhengfei Zhu  1   2, Weixin Zhao  1   2, Qin Lin  8, Huanjun Yang  1   2, Xiangpeng Zheng  9, Jialiang Zhou  10, Guang Huang  11, Ling Li  1   2, Jiancheng Li  12, Zhi Zhang  13, Guoren Zhou  14, Dayong Gu  3, Mingyu Du  3, Miao Mo  15, HuiXun Jia  16, Zhen Zhang  1   2, Kuaile Zhao  1   2 (Affiliations 1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 3 Department of Radiation Oncology, Jiangsu Cancer Hospital, Jiangsu Institute Of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China. 4 Department of Radiation Oncology, Gansu Province Cancer Hospital, Lanzhou, China. 5 Department of Radiation Oncology, Fudan University Shanghai Cancer Center Minhang Branch Hospital, Shanghai, China. 6 Department of Radiation Oncology, Jiangxi Province Cancer Hospital, Nanchang, China. 7 Department of Radiation Oncology, Shanxi Province Cancer Hospital, Taiyuan, China. 8 Department of Radiation Oncology, First Affiliated Hospital of Xiamen University, Xiamen, China. 9 Department of Radiation Oncology, Huadong Hospital Affiliated to Fudan University, Shanghai, China. 10 Department of Radiation Oncology, Affiliated Hospital of Jiangnan University, Wuxi, China. 11 Department of Radiation Oncology, Hainan Province People\'s Hospital, Haikou, China. 12 Department of Radiation Oncology, Fujian Province Cancer Hospital, Fuzhou, China. 13 Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute Of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China. 14 Department of Internal Medicine, Jiangsu Cancer Hospital, Jiangsu Institute Of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China. 15 Department of Cancer Prevention & Clinical Statistics Center, Fudan University Shanghai Cancer Center, Shanghai, China. 16 Shanghai General Hospital, Shanghai, China.)

出处: JAMA network open 2022 Vol.5 No.2 Pe220120

摘要: Importance: Multiple paclitaxel-based regimens are widely used in chemoradiation therapy against esophageal cancer, including regimens combining pacli ...

作者: Minjie Zhao  1, Shuzhi Zhao  2   3   4   5   6, Min Tang  2   3   4   5   6, Tao Sun  2   3   4   5   6   7, Zhi Zheng  2   3   4   5   6, Mingming Ma  2   3   4   5   6 (Affiliations 1 Department of Ophthalmology, Yixing People\'s Hospital, Jiangsu University, Zhenjiang, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai, China. 3 National Clinical Research Center for Eye Diseases, Shanghai, China. 4 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. 5 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. 6 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 7 Shanghai Eye Diseases Prevention & Treatment Center/Shanghai Eye Hospital, Shanghai, China.)

出处: Investigative ophthalmology & visual science 2022 Vol.63 No.3 P8

摘要: Purpose: To clarify the expression of biomarkers of retinal glial cell activation in the aqueous humor (AH) of patients with and without age-related c ...

作者: Liqun Lou  1   2, Shuangbo Kong  2, Yunyan Sun  3, Zhenbo Zhang  1   4, Haibin Wang  2 (Affiliations 1 Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. 2 Fujian Provincial Key Laboratory of Reproductive Health Research, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. 3 Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China. 4 Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.)

出处: Frontiers in cell and developmental biology 2022 Vol.10 P844623

关键词: coculture model;drug screening;epithelium;genetic manipulation;human endometrial organoids.

摘要: Since traditional two-dimensional (2D) cell culture cannot meet the demand of simulating physiological conditions in vivo, three-dimensional (3D) cult ...

[外文期刊] KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis
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作者: Mingzi Li  1, Mingxun Zhang  2   3, Muling Chen  1, Jiantao Xiao  4, Xingyu Mu  1, Jingtao Peng  5, Jie Fan  1 (Affiliations 1 Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai, China. 2 Department of Pathology, the First Affiliated Hospital of Ustc, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. 3 Intelligent Pathology Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. 4 Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. 5 Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.)

出处: Cell cycle (Georgetown, Tex.) 2022 P1-15

关键词: KLF2;PIM1;circZKSCAN1;clear cell renal cell carcinoma;miR-1294.

摘要: Clear cell renal cell carcinoma (ccRCC) is one of the most common and lethal types of urologic cancer. With low survival rates among patients in advan ...

[外文期刊] Multi-stage screening cell-free seminal mRNAs to diagnose completion of meiosis and predict testicular sperm retrieval in men with non-obstructive azoospermia
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作者: Yuwan Dai  1   2, Xiangbin Kong  3, Chencheng Yao  4, Chengliang Xiong  1   5, Zheng Li  4, Honggang Li  1   5 (Affiliations 1 Institute of Reproductive Health/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 2 Henan Provincial People\'s Hospital, Henan, China. 3 Department of Reproductive Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 4 Department of Andrology, the Center for Men\'s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Wuhan Tongji Reproductive Hospital, Wuhan, China.)

出处: Andrology 2022

关键词: azoospermia;male factor infertility;meiosis;non-invasive;semen;sperm retrieval.

摘要: Background: Differential diagnosis of men with subtypes of non-obstructive azoospermia (NOA) is important for their treatment. Many genes are transcri ...

[外文期刊] Role of TRPC6 in kidney damage after acute ischemic kidney injury
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作者: Zhihuang Zheng  1   2   3, Dmitry Tsvetkov  4   5   6, Theda Ulrike Patricia Bartolomaeus  2   7, Cem Erdogan  8, Ute Krügel  9, Johanna Schleifenbaum  8, Michael Schaefer  9, Bernd Nürnberg  10, Xiaoning Chai  9, Friedrich-Alexander Ludwig  11, Gabriele N\'diaye  2   7, May-Britt Köhler  2   7, Kaiyin Wu  12, Maik Gollasch  13   14   15, Lajos Markó  16   17   18   19 (Affiliations 1 Department of Nephrology/Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. 2 Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité Universitätsmedizin, Berlin, Germany. 3 Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 4 Department of Nephrology/Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. dmitry.tsvetkov@charite.de. 5 Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité Universitätsmedizin, Berlin, Germany. dmitry.tsvetkov@charite.de. 6 Department of Geriatrics, University of Greifswald, University District Hospital Wolgast, Greifswald, Germany. dmitry.tsvetkov@charite.de. 7 Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. 8 Institute of Vegetative Physiology, Charité-Universitätsmedizin Berlin, Berlin, Germany. 9 Rudolf Boehm Institute for Pharmacology and Toxicology, Leipzig University, Leipzig, Germany. 10 Department of Pharmacology, Experimental Therapy and Toxicology and Interfaculty Center of Pharmacogenomics and Drug Research, University of Tübingen, Tübingen, Germany. 11 Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. 12 Department of Pathology, Charité-Universitätsmedizin Berlin, Berlin, Germany. 13 Department of Nephrology/Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. maik.gollasch@charite.de. 14 Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité Universitätsmedizin, Berlin, Germany. maik.gollasch@charite.de. 15 Department of Geriatrics, University of Greifswald, University District Hospital Wolgast, Greifswald, Germany. maik.gollasch@charite.de. 16 Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité Universitätsmedizin, Berlin, Germany. lajos.marko@charite.de. 17 DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany. lajos.marko@charite.de. 18 Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany. lajos.marko@charite.de. 19 Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. lajos.marko@charite.de.)

出处: Scientific reports 2022 Vol.12 No.1 P3038

摘要: Transient receptor potential channel subfamily C, member 6 (TRPC6), a non-selective cation channel that controls influx of Ca 2+ and other monovalent ...

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