作者： Erjiao Qiang  ¹, Hu Xu  ² （Affiliations ¹ Department of Pathology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, 200080. ² Health Science Center, East China Normal University, Shanghai, China, 200241.）

出处： Prostaglandins & other lipid mediators 2024

关键词： COX-2;Hepatic metabolism;Liver disease;PGE(2).

摘要： The liver plays a central role in systemic metabolism and drug degradation. However, it is highly susceptible to damage due to various factors, includ ...

作者： Luni Zhang ^{#  1   2}, Caixia Jia ^{#  2}, Shiyao Gu  ², Jing Chen  ², Rong Wu  ^{1   2} （Affiliations ¹ Department of Ultrasound, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. ² Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Quantitative imaging in medicine and surgery 2024

关键词： Carotid plaque;elasticity;neovascularization;stroke;ultrasound (US).

摘要： Background: Intraplaque neovascularization (IPN) is a biomarker for vulnerable atherosclerotic plaques and can be effectively visualized via contrast- ...

作者： Min Tang ^{#  1}, Han Cao ^{#  2   3}, Yunqin Ma ^{#  1}, Shuangshuang Yao  ¹, Xiaohui Wei  ¹, Yijiong Tan  ⁴, Fang Liu  ¹, Yongde Peng  ^{5   6}, Nengguang Fan  ⁷ （Affiliations ¹ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Endocrinology and Metabolism, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. ³ Department of Endocrinology, Songjiang District Central Hospital, Shanghai, China. ⁴ Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yongdepeng0908@126.com. ⁶ Department of Endocrinology and Metabolism, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. yongdepeng0908@126.com. ⁷ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. fngwlp@163.com.）

出处： Journal of translational medicine 2024

关键词： Nonalcoholic fatty liver disease;Transforming growth factor beta-activated Kinase 1;Ubiquitin specific protease 13;Ubiquitination.

摘要： Background: The molecular mechanisms underlying nonalcoholic fatty liver disease (NAFLD) remain to be fully elucidated. Ubiquitin specific protease 13 ...

作者： Ling Ren ^{#  1}, Jiao Xia ^{#  2}, Chang Huang ^{#  1}, Yun Bai  ³, Jin Yao  ⁴, Dan Li  ⁵, Biao Yan  ⁶ （Affiliations ¹ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. ³ College of Information Science, Shanghai Ocean University, Shanghai, People's Republic of China. ⁴ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, People's Republic of China yanbiao@sjtu.edu.cn jinyao1972@126.com lenslab@163.com. ⁵ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, People's Republic of China yanbiao@sjtu.edu.cn jinyao1972@126.com lenslab@163.com. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China yanbiao@sjtu.edu.cn jinyao1972@126.com lenslab@163.com.）

出处： BMJ open diabetes research & care 2024

关键词： Diabetes Complications;Diabetic Retinopathy;angiogensis.

摘要： Introduction: Diabetic retinopathy (DR) is a common vascular complication of diabetes mellitus and a leading cause of vision loss worldwide. Endotheli ...

作者： Qingjie Kong  ^{1   2}, Fudong Li  ³, Kaiqiang Sun  ³, Xiaofei Sun  ³, Jun Ma  ¹ （Affiliations ¹ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical University, Shanghai, China. ³ Department of Orthopedic Surgery, Spine Center, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.）

出处： CNS neuroscience & therapeutics 2024

关键词： HDAC2;cauda equina injury;ferroptosis;neuroinflammation;valproic acid.

摘要： Introduction: Persistent neuroinflammatory response after cauda equina injury (CEI) lowers nociceptor firing thresholds, accompanied by pathological p ...

作者： Wen Yang  ^{1   2   3}, Rong Hua  ^{1   3}, Yunxia Cao  ^{1   3}, Xiaojin He  ^{2   3} （Affiliations ¹ Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. ² Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, China.）

出处： Andrology 2024

关键词： MI pathogenesis;biomarkers;male infertility (MI);metabolic profiling;metabolomics;non‐genetic factors.

摘要： The incidence of male infertility (MI) is rising annually. According to epidemiological studies, environmental pollution (e.g., organic, inorganic, an ...

作者： Xiao-Wei Wei ^{#  1}, Dong-Mei Zhou ^{#  2}, Lei Han  ³, Yi Lin  ¹, Xiao-Wei Xi  ⁴, Jiang-Dong Xiang  ⁴ （Affiliations ¹ Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Obstetrics and Gynecology, Shanghai General Hospital of Nanjing Medical University, Nanjing Medical University School of Medicine, Shanghai, China. ³ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Gynecology and Obstetrics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Quantitative imaging in medicine and surgery 2024

作者： Thomas R Kolodecik  ¹, Xiaoyu Guo  ², Christine A Shugrue  ³, Xiaojia Guo  ⁴, Gary V Desir  ⁵, Li Wen  ⁶, Fred Sanford Gorelick  ⁴ （Affiliations ¹ Internal Medicine -- Digestive Diseases, Yale University, New Haven, CT, United States. ² Internal Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. ³ Internal Medicine, Yale School of Medicine, New Haven, CT, United States. ⁴ Internal Medicine, Yale School of Medicine, West Haven, CT, United States. ⁵ School of Medicine, Yale School of Medicine, New Haven, CT, United States. ⁶ Shanghai General Hospital, Shanghai, China.）

出处： American journal of physiology. Gastrointestinal and liver physiology 2024

关键词： ERCP;cerulein;inflammation;pancreatitis;renalase.

摘要： Acute pancreatitis, an acute inflammatory injury of the pancreas, lacks a specific treatment. The circulatory protein renalase is produced by the kidn ...

作者： Liqin Gao  ¹, Yanping Song  ², Xiaodong Sun  ³, Junjun Zhang  ⁴, Yuling Liu  ⁵, Youxin Chen  ⁶, Zhifeng Wu  ⁷, Ye Jian  ⁸, Xiaoling Liu  ⁹, Lin Lv  ¹⁰, Shaojun Chen  ¹¹, Yu-Sheng Wang  ¹², Nan Chen  ¹³, Xiao Ke  ¹⁴, Feng Zhang  ¹ （Affiliations ¹ Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China. ² Department of Ophthalmology, Chinese PLA General Hospital of Central Theater Command, Wuhan, China. ³ Department of Ophthalmology, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai General Hospital, Shanghai, China. ⁴ Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, China. ⁵ Department of Ophthalmology, Peking University Third Hospital, Beijing, China. ⁶ Department of Ophthalmology, Peking Union Medical College Hospital, Beijing, China. ⁷ Department of Ophthalmology, Wuxi No.2 People's Hospital, Nanjing Medical University, Wuxi, China. ⁸ Department of Ophthalmology, Daping Hospital and Institute of Surgery Research, Army Medical University, Chongqing, China. ⁹ National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China. ¹⁰ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. ¹¹ Department of Ophthalmology, He Eye Specialist Hospital, Chongqing, China. ¹² Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi'an, China. ¹³ Department of Ophthalmology, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China. ¹⁴ Medical Research Center, Chengdu Kanghong Biotechnology Inc, Chengdu, China.）

出处： Acta ophthalmologica 2024

关键词： Conbercept;best‐corrected visual acuity;central retinal thickness;choroidal neovascularization;pathological myopia.

摘要： Purpose: To evaluate the safety and efficacy of intravitreal injections of 0.5 mg conbercept in patients with choroidal neovascularization secondary t ...

作者： Jiajia Li ^{#  1   2}, Zhouyu Guan ^{#  1}, Jing Wang ^{#  3}, Carol Y Cheung  ⁴, Yingfeng Zheng  ⁵, Lee-Ling Lim  ⁶, Cynthia Ciwei Lim  ⁷, Paisan Ruamviboonsuk  ⁸, Rajiv Raman  ⁹, Leonor Corsino  ¹⁰, Justin B Echouffo-Tcheugui  ¹¹, Andrea O Y Luk  ^{12   13   14   15}, Li Jia Chen  ⁴, Xiaodong Sun  ¹⁶, Haslina Hamzah  ¹⁷, Qiang Wu  ¹⁸, Xiangning Wang  ¹⁸, Ruhan Liu  ^{1   2}, Ya Xing Wang  ¹⁹, Tingli Chen  ³, Xiao Zhang  ²⁰, Xiaolong Yang  ³, Jun Yin  ¹, Jing Wan  ²¹, Wei Du  ²¹, Ten Cheer Quek  ¹⁷, Jocelyn Hui Lin Goh  ¹⁷, Dawei Yang  ⁴, Xiaoyan Hu  ⁴, Truong X Nguyen  ⁴, Simon K H Szeto  ⁴, Peranut Chotcomwongse  ⁸, Rachid Malek  ²², Nargiza Normatova  ²³, Nilufar Ibragimova  ²⁴, Ramyaa Srinivasan  ⁹, Pingting Zhong  ⁵, Wenyong Huang  ⁵, Chenxin Deng  ²⁵, Lei Ruan  ²⁵, Cuntai Zhang  ²⁵, Chenxi Zhang  ²⁶, Yan Zhou  ²⁶, Chan Wu  ²⁶, Rongping Dai  ²⁶, Sky Wei Chee Koh  ²⁷, Adina Abdullah  ²⁸, Nicholas Ken Yoong Hee  ²⁹, Hong Chang Tan  ³⁰, Zhong Hong Liew  ⁷, Carolyn Shan-Yeu Tien  ⁷, Shih Ling Kao  ^{31   32}, Amanda Yuan Ling Lim  ^{31   32}, Shao Feng Mok  ^{31   32}, Lina Sun  ³³, Jing Gu  ³³, Liang Wu  ¹, Tingyao Li  ^{1   2}, Di Cheng  ¹, Zheyuan Wang  ^{1   2}, Yiming Qin  ^{1   2}, Ling Dai  ^{1   2}, Ziyao Meng  ^{1   2}, Jia Shu  ^{1   2}, Yuwei Lu  ¹, Nan Jiang  ^{1   2}, Tingting Hu  ¹, Shan Huang  ^{1   2}, Gengyou Huang  ^{1   2}, Shujie Yu  ¹, Dan Liu  ¹, Weizhi Ma  ³⁴, Minyi Guo  ¹, Xinping Guan  ³⁵, Xiaokang Yang  ², Covadonga Bascaran  ³⁶, Charles R Cleland  ³⁶, Yuqian Bao  ¹, Elif I Ekinci  ^{37   38   39}, Alicia Jenkins  ^{39   40   41}, Juliana C N Chan  ^{12   13   14   15}, Yong Mong Bee  ³⁰, Sobha Sivaprasad  ⁴², Jonathan E Shaw  ³⁸, Rafael Simó  ^{43   44}, Pearse A Keane  ^{42   45}, Ching-Yu Cheng  ^{17   46}, Gavin Siew Wei Tan  ¹⁷, Weiping Jia  ⁴⁷, Yih-Chung Tham  ^{48   49   50}, Huating Li  ⁵¹, Bin Sheng  ^{52   53}, Tien Yin Wong  ^{54   55   56   57} （Affiliations ¹ Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China. ² MOE Key Laboratory of AI, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China. ³ Department of Ophthalmology, Huadong Sanatorium, Wuxi, China. ⁴ Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. ⁵ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China. ⁶ Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. ⁷ Department of Renal Medicine, Singapore General Hospital, SingHealth-Duke Academic Medical Centre, Singapore, Singapore. ⁸ Faculty of Medicine, Department of Ophthalmology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand. ⁹ Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India. ¹⁰ Department of Medicine, Division of Endocrinology, Metabolism and Nutrition, and Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, USA. ¹¹ Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA. ¹² Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. ¹³ Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. ¹⁴ Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. ¹⁵ Asia Diabetes Foundation, Hong Kong Special Administrative Region, China. ¹⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁷ Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. ¹⁸ Department of Ophthalmology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁹ Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. ²⁰ The People's Hospital of Sixian County, Anhui, China. ²¹ Department of Endocrinology and Metabolism, Shanghai Eighth People's Hospital, Shanghai, China. ²² Department of Internal Medicine, Setif University Ferhat Abbas, Setif, Algeria. ²³ Ophthalmology Department at Tashkent Advanced Training Institute for Doctors, Tashkent, Uzbekistan. ²⁴ Charity Union of Persons with Disabilities and People with Diabetes UMID, Tashkent, Uzbekistan. ²⁵ Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ²⁶ Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. ²⁷ National University Polyclinics, National University Health System, Department of Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ²⁸ Department of Primary Care Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia. ²⁹ Department of Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia. ³⁰ Department of Endocrinology, Singapore General Hospital, Singapore, Singapore. ³¹ Division of Endocrinology, University Medicine Cluster, National University Health System, Singapore, Singapore. ³² Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ³³ Department of Internal Medicine, Huadong Sanatorium, Wuxi, China. ³⁴ Institute for AI Industry Research, Tsinghua University, Beijing, China. ³⁵ Department of Automation and the Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai Jiao Tong University, Shanghai, China. ³⁶ International Centre for Eye Health, London School of Hygiene and Tropical Medicine, University of London, London, UK. ³⁷ Department of Endocrinology, Austin Health, Melbourne, Victoria, Australia. ³⁸ Department of Medicine, The University of Melbourne (Austin Health), Melbourne, Victoria, Australia. ³⁹ Australian Centre for Accelerating Diabetes Innovations, The University of Melbourne, Parkville, Victoria, Australia. ⁴⁰ Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. ⁴¹ NHMRC Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia. ⁴² NIHR Moorfields Biomedical Research Centre, Moorfields Eye Hospital, London, UK. ⁴³ Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Madrid, Spain. ⁴⁴ Diabetes and Metabolism Research Unit, Vall d'Hebron Research Institut, Autonomous University of Barcelona, Barcelona, Spain. ⁴⁵ Institute of Ophthalmology, University College London, London, UK. ⁴⁶ Center for Innovation and Precision Eye Health and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ⁴⁷ Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China. wpjia@sjtu.edu.cn. ⁴⁸ Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. thamyc@nus.edu.sg. ⁴⁹ Center for Innovation and Precision Eye Health and Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. thamyc@nus.edu.sg. ⁵⁰ Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. thamyc@nus.edu.sg. ⁵¹ Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China. huarting99@sjtu.edu.cn. ⁵² Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases, Department of Computer Science and Engineering, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China. shengbin@sjtu.edu.cn. ⁵³ MOE Key Laboratory of AI, School of Electronic, Information, and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China. shengbin@sjtu.edu.cn. ⁵⁴ Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. wongtienyin@tsinghua.edu.cn. ⁵⁵ School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China. wongtienyin@tsinghua.edu.cn. ⁵⁶ Beijing Tsinghua Changgung Hospital, Beijing, China. wongtienyin@tsinghua.edu.cn. ⁵⁷ Zhongshan Ophthalmic Center, Guangzhou, China. wongtienyin@tsinghua.edu.cn.）

出处： Nature medicine 2024

摘要： Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary care phys ...