作者： Yifei Zhang^1,2;Ruixin Liu^1,2;Yufei Chen^1,2;Zhiwen Cao^1,2;Cong Liu^1,2;Riqiang Bao¹;Yufan Wang³;Shan Huang⁴;Shijia Pan⁵;Li Qin⁶;Jiqiu Wang¹;Guang Ning¹CA1;Weiqing Wang^1,7CA2 （¹Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;²These authors contributed equally;³Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;⁴Department of Endocrinology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China;⁵Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China;⁶Department of Endocrinology, Chongming hospital affiliated to Shanghai University of Health & Medicine Sciences, Shanghai 202150, China;⁷Lead contact）

出处： Cell Metabolism 2025

摘要： Akkermansia muciniphila is a promising target for managing obesity and type 2 diabetes (T2D), but human studies are limited. We conducted a 12-week ra ...

作者： Hui Ran ^{#  1}, Yemin Zhu ^{#  2}, Ruyuan Deng ^{#  1}, Qi Zhang  ¹, Xisheng Liu  ³, Ming Feng  ², Jie Zhong  ², Shuhai Lin  ², Xuemei Tong  ⁴, Qing Su  ⁵ （Affiliations ¹ Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665, Kong Jiang Road, Shanghai, 200092, China. ² Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China. ³ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100, Haining Road, Shanghai, 200080, China. ⁴ Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China. xuemeitong@shsmu.edu.cn. ⁵ Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665, Kong Jiang Road, Shanghai, 200092, China. suqing@xinhuamed.com.cn.）

出处： Journal of experimental & clinical cancer research : CR 2025

作者： Jiawei Zhang  ^{1   2}, Feng Ding  ³, Yitian Guo  ^{1   2}, Xiaoying Wei  ^{2   4}, Jibo Jing  ⁵, Feng Xu  ⁶, Huixing Chen  ⁷, Zhongying Guo  ⁸, Zonghao You  ^{1   2}, Baotai Liang  ^{1   2}, Ming Chen  ^{1   2}, Dongfang Jiang  ⁹, Xiaobing Niu  ¹⁰, Xiangxue Wang  ¹¹, Yifeng Xue  ^{12   13} （Affiliations ¹ Department of Urology, Zhongda Hospital, Southeast University, Nanjing, China. ² Department of Medical College, Southeast University, Nanjing, China. ³ Nanjing University of Information Science and Technology, Nanjing, China. ⁴ Department of Pathology, Zhongda Hospital, Southeast University, Nanjing, China. ⁵ Department of Urology, Peking Union Medical College Hospital, Beijing, China. ⁶ Jinhu County People's Hospital, Huai'an, China. ⁷ Shanghai General Hospital, Urologic Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁸ Department of Pathology, Huaian First People's Hospital, Huai'an, China. ⁹ Department of Urology, The People's Hospital of Danyang, Danyang, China. 13912823872@163.com. ¹⁰ Department of Urology, Huaian First People's Hospital, Huai'an, China. nxbhayy@163.com. ¹¹ Nanjing University of Information Science and Technology, Nanjing, China. xwang@nuist.edu.cn. ¹² The Affiliated Jintan Hospital of Jiangsu University, Changzhou, China. 494809908@qq.com. ¹³ Changzhou jintan first people's hospital, Changzhou, China. 494809908@qq.com.）

出处： Scientific reports 2025

摘要： Biochemical recurrence (BCR) of prostate cancer (PCa) negatively impacts patients' post-surgery quality of life, and the traditional predictive models ...

作者： Yikeng Huang  ¹, Xiaoyin Xu  ¹, Xinyu Zhang  ¹, Xinyu Zhu  ¹, Bo Li  ^{1   2}, Mingming Ma  ¹, Chuandi Zhou  ³, Chufeng Gu  ¹, Yujin Jiang  ¹, Yanlin Wu  ⁴, Zhi Zheng  ^{1   5   6}, Shuzhi Zhao  ¹ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai engineering center for precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ² Department of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, China. ³ Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. ⁴ Department of Ophthalmology, Fuyang Fifth People's Hospital, Fuyang City, Anhui Province, China. ⁵ Ningde Municipal Hospital of Ningde Normal University, Fujian Medical University, Ningde City, Fujian Province, China. ⁶ Fujian Medical University, Fuzhou City, Fujian Province, China.）

出处： Diabetes & vascular disease research 2025

关键词： Mendelian randomization;Sleep traits;UK Biobank;daytime sleepiness;diabetic retinopathy;observational study.

摘要： Aims: To evaluate the potential causal role of sleep traits (STs) on diabetic retinopathy (DR). Methods: The cross-sectional study included 23,851 pat ...

作者： Jingwen Jiang MD^1,2;Kangjie Kong MD^1,2;Fengbin Lin MD, PhD¹CA1;Fengqi Zhou OD³;Yunhe Song MD, PhD¹;Xiaoyi Liu MD¹;Zige Fang MD¹;Dilimulati Xiaokaiti MD^1,4;Ling Jin MSc¹;Meiling Chen MBBS¹;Jost B. Jonas MD, PhD^5,6;Dennis S.C. Lam MD^7,8;Linda M. Zangwill PhD⁹;Xiaodong Sun MD, PhD^10,11,12CA2;Robert N. Weinreb MD⁹CA3;Fei Li MD, PhD¹CA4;Xiulan Zhang MD, PhD¹CA5;Xiulan Zhang;Yizhi Liu;Lin Lv （¹State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510623, China;²The three authors contributed equally.;³Mayo Clinic College of Medicine, Rochester, MN 55902, USA;⁴Department of Ophthalmology Center, The First People’s Hospital of Kashi Prefecture, Kashi 844000, China;⁵Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France;⁶Singapore Eye Research Institute, Singapore National Eye Center, Singapore;⁷The International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China;⁸The C-MER Dennis Lam & Partners Eye Center, C-MER International Eye Care Group, Hong Kong, China;⁹Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, LaJolla, CA;¹⁰Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China;¹¹National Clinical Research Center for Ophthalmic Diseases, Shanghai 200080, China;¹²Shanghai Key Laboratory of Fundus Diseases, Shanghai 200080, China）

出处： Ophthalmology 2025

摘要： Purpose To describe the longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGC-I ...

作者： Jie Mei  ^{1   2}, Zhiwen Luo  ³, Yun Cai  ⁴, Renwen Wan  ³, Zhiwen Qian  ⁵, Jiahui Chu  ^{1   2}, Yaying Sun  ⁶, Yuxin Shi  ⁷, Ying Jiang  ⁸, Yan Zhang  ^{5   8}, Yongmei Yin  ^{1   9   10}, Shiyi Chen  ³ （Affiliations ¹ Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. ² The First Clinical Medicine College, Nanjing Medical University, Nanjing 211166, China. ³ Department of Sports Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China. ⁴ Department of Central Laboratory, Changzhou Jintan First People's Hospital, Jiangsu University, Changzhou 213200, China. ⁵ Departments of Gynecology, Wuxi Maternal and Child Health Care Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China. ⁶ Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁷ Department of Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Nanjing 211166, China. ⁸ Department of Gynecology, The Obstetrics and Gynecology Hospital Affiliated to Jiangnan University, Wuxi 214023, China. ⁹ Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing 211166, China. ¹⁰ Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 211166, China.）

出处： Research (Washington, D.C.) 2025

摘要： Increasing evidence has shown that physical exercise remarkably inhibits oncogenesis and progression of numerous cancers and exercise-responsive micro ...

作者： Wei Du¹;Chang Xu²;Zhiyuan Cheng³;Zhenyu Sun⁴;Shicheng Guo⁵;Qiang Li⁶;Yuanlin Song⁷;Bo Shen⁸CA1;Yang Bao⁹CA2;Junjie Wu^7,10CA3 （¹College of Basic Medicine, Naval Medical University, Shanghai, China;²Clinical College of Xiangnan University, Chenzhou, China;³Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴Department of Traditional Chinese Medicine, Naval Medical University, Shanghai, China;⁵State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China;⁶Department of Respiratory and Critical Care Medicine, Shanghai East Hospital, Tongji University, Shanghai, China;⁷Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China;⁸The Affilated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, China;⁹Department of Thoracic Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China;¹⁰Shanghai Geriatric Medical Center, Shanghai, China）

出处： Oncology 2025

关键词： TYMS;rs3819102;Lung cancer;Single nucleotide polymorphism;Prognosis

摘要： Introduction: With high incidence and mortality rates, lung cancer is now one of the most common cancers in the world. The 5-year survival rate of lun ...

作者： Jin-Fu Xu MD^{1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19}CA1;Hui-Zhen Zheng MD^{1,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Hai-Wen Lu MD^{1,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Ling-Wei Wang MD^{20,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Bin Wu MD^{21,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Xiao-Dong Lv MD^{22,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Hong Luo MD^{23,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Jian Feng MD^{24,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Yuan-Yuan Li MD^{25,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Lin Liu MD^{26,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Jin-Guang Jia MD^{27,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Wei-Qiang Mo MD^{28,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Hong-Yan Gu MD^{29,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Jing-Bo Jiang MD^{30,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Dao-Xin Wang MD^{31,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Bin Wang MD^{32,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Li Li MD^{33,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Zhi Yuan MD^{34,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Wen Li MD^{35,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Min Xie MD^{36,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19} （¹Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Institute of Respiratory Medicine, School of Medicine, Tongji University, Shanghai, China;²Department of Respiratory and Critical Care Medicine, Huadong Hospital, Fudan University, Shanghai, China;³Contributed equally as first authors;⁴Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Institute of Respiratory Medicine, School of Medicine, Shanghai Jiaotong University, Shanghai, China;⁵Division of Respiratory Medicine and Gastroenterology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK;⁶Department of Respiratory and Critical Care Medicine, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China;⁷Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, China;⁸Department of Pulmonary and Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China;⁹Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China;¹⁰Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China;¹¹State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;¹²Guangzhou National Laboratory, Guangzhou, China;¹³Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China;¹⁴Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;¹⁵Department of Geriatric Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China;¹⁶Department of Respiratory Medicine, Center for Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, State Key Laboratory for Zoonotic Diseases, The First Hospital of Jilin University, Changchun, China;¹⁷Department of Pulmonary and Critical Care Medicine, Anning First People's Hospital Affiliated to Kunming University of Science and Technology, Kunming, China;¹⁸Department of Respiratory Medicine, The Eighth People's Hospital of Shanghai, Shanghai, China;¹⁹Department of Respiratory and Critical Care Medicine, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China;²⁰Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital, Shenzhen Institute of Respiratory Diseases, Shenzhen, China;²¹Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China;²²Department of Respiratory Medicine, Affiliated Hospital of Jiaxing University, Zhejiang, China;²³Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, China;²⁴Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Nantong Key Laboratory of Respiratory Medicine, Nantong, China;²⁵Department of Respiratory Medicine, Branch of National Clinical Research Center for Respiratory Disease, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China;²⁶Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Immunological Diseases, Guizhou Provincial People's Hospital, Guiyang, China;²⁷Department of Respiratory and Critical Care Medicine, Zhengzhou People's Hospital, Zhengzhou, China;²⁸Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China;²⁹Department of Respiratory Medicine, Affiliated Nantong Hospital of Shanghai University, Nantong, China;³⁰Department of Respiratory and Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, China;³¹Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;³²Department of Respiratory and Critical Care Medicine, Huzhou Central Hospital, Huzhou Hospital Affiliated to Zhejiang University School of Medicine, Huzhou, China;³³Department of Respiratory and Critical Care Medicine, Baoshan Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;³⁴Department of Respiratory and Critical Care Medicine, Medical Service Community of People's Hospital of Fenghua, Ningbo, China;³⁵Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China;³⁶Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China）

出处： The Lancet Respiratory Medicine 2025

摘要： Background Bronchiectasis is a disease with a global impact, but most published data come from high-income countries. We aimed to describe the clinica ...

作者： Ningning Song¹;Xinquan Xi¹;Kuan Yang²CA1;Chongzhe Pei²CA2;Lingzhou Zhao³CA3 （¹Department of Breast Surgery, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Shushan District, Hefei, Anhui 230022, PR China;²Department of Cardiology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping, Tianjin 300052, PR China;³Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China）

出处： Ecotoxicology and Environmental Safety 2025

关键词： EDCs;Blood Metabolome;Epigenetics;Breast cancer;Mendelian Randomization

摘要： Current research on the relationship between environmental endocrine disrupting chemicals (EDCs) and breast cancer remains insufficient, with limited ...

作者： Wei Huang  ¹, Chengcheng Zhang, Weibiao Zeng, Dong Lin, Jiang Fan, Liang Wu （Affiliation ¹ Department of Thoracic Surgery, Shanghai General Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, PRC.）

出处： International journal of surgery (London, England) 2025

摘要： Background: The localization of pulmonary nodules is crucial for surgical intervention. However, a safe, simple, and efficient method remains elusive. ...