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作者: Yifei Zhang  1, Yufan Wang  2, Guang Ning  1, Ping He  3, Weiqing Wang  4 (Affiliations 1 Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai National Clinical Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. 2 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Link-Healthcare Engineering and Information Department, Shanghai Hospital Development Center, Shanghai, China. 4 Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai National Clinical Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: wqingw61@shsmu.edu.cn.)

出处: Lancet (London, England) 2022

作者: Lixia Zhou  1, Huiqin Wu  2, Xingli Bai  1, Shuyun Min  1, Jiawen Zhang  3   4, Cunli Li  1 (Affiliations 1 Department of Obstetrics and Gynecology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Obstetrics and Gynecology, Shanghai Songjiang District Maternal and Child Health Hospital, Shanghai, China. 3 Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Pathology oncology research : POR 2022

关键词: GALNT2;anti-tumor immune response;cervical cancer;immune-related biomarker;survival

摘要: Identification of novel biomarkers is helpful for the diagnosis and treatment of cervical cancer. Mucin glycosylating enzyme GALNT2 modulates mucin O- ...

作者: Yushuai Mi  1, Quanhui Li  1, Bingtian Liu  1, Dehai Wang  1, Ziping Liu  1, Tianshi Wang  1, Yuan Wang  1, Yifeng Zang  1, Yan Zhou  1, Yugang Wen  2, Yinlu Ding  3 (Affiliations 1 Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Beiyuan Street, Jinan, 250033, China. 2 Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, 85 Wujin Road, Shanghai, 200080, China. 3 Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Beiyuan Street, Jinan, 250033, China. dingyinlu@126.com.)

出处: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2022

关键词: Gastric cancer;Glycolysis;Prognosis;uMtCK

摘要: Background: Ubiquitous mitochondrial creatine kinase (uMtCK) transfers high-energy phosphates from mitochondrially generated ATP to creatine to genera ...

作者: Yiran Wei  1, Chao Li  1   2   3, Zaixu Cui  4, Roxanne Claudeve Mayrand  1, Jingjing Zou  5, Adrianna Leanne Kok Chi Wong  1, Rohitashwa Sinha  1, Tomasz Matys  6, Carola Bibiane Schönlieb  2, Stephen John Price  1 (Affiliations 1 Cambridge Brain Tumour Imaging Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. 2 The Centre for Mathematical Imaging in Healthcare, Department of Applied Mathematics and Theoretical Physics, Cambridge, UK. 3 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. 4 Department of Psychiatry, University of Pennsylvania, Philadelphia, USA. 5 Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California, San Diego, USA. 6 Department of Radiology, University of Cambridge, Cambridge, UK.)

出处: Brain : a journal of neurology 2022

关键词: brain connectome;brain reorganisation;glioblastoma;survival analysis;tumour invasion

摘要: Glioblastoma is characterised by diffuse infiltration into the surrounding tissue along white matter tracts. Identifying the invisible tumour invasion ...

作者: Cheng Chen  1, Adam Kassan  2, Diana Castañeda  3, Mohanad Gabani  4, Soo-Kyoung Choi  5, Modar Kassan  6 (Affiliations 1 Department of Emergency and Critical Care, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 West Coast University, School of Pharmacy, Los Angeles, CA, 90004, USA. 3 California State University, Los Angeles, Los Angeles, CA, 90032, USA. 4 Cardiovascular Division, Department of Medicine, and Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, IA City, IA, 52242, USA. 5 Department of Physiology, College of Medicine, Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, 03722, Korea. 6 Cardiovascular Division, Department of Medicine, and Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, IA City, IA, 52242, USA. modar-kassan@uiowa.edu.)

出处: Hypertension research : official journal of the Japanese Society of Hypertension 2022

作者: Yumeng Zhang  1   2, Jingfa Zhang  1   2, Xiaodong Sun  1   2 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China. 2 National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China.)

出处: Journal of ophthalmology 2022

摘要: Purpose: To investigate the effect and underlying mechanism of intravitreal antivascular endothelial growth factor (VEGF) in patients with putative or ...

作者: De-Cui Cheng  1, Yao Su  1, Feifei Li  1, Xianming Xu  1 (Affiliation 1 Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai, China.)

出处: Frontiers in pharmacology 2022

关键词: fetus;hypercholesterolemia;hypertriacylglycerolemia;insulin;pregnancy.

作者: Hongsheng Wang #  1   2, Xinmeng Jin #  1   2, Yangfeng Zhang #  1   2, Zhuoying Wang  1   2, Tao Zhang  1   2, Jing Xu  1   2, Jiakang Shen  1   2, Pengfei Zan  1   2, Mengxiong Sun  1   2, Chongren Wang  1   2, Yingqi Hua  3   4, Xiaojun Ma  5   6, Wei Sun  7   8 (Affiliations 1 Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China. 2 Shanghai Bone Tumor Institution, Shanghai, China. 3 Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China. yhua@shsmu.edu.cn. 4 Shanghai Bone Tumor Institution, Shanghai, China. yhua@shsmu.edu.cn. 5 Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China. ma-xiaojun@foxmail.com. 6 Shanghai Bone Tumor Institution, Shanghai, China. ma-xiaojun@foxmail.com. 7 Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China. viv-sun@sjtu.edu.cn. 8 Shanghai Bone Tumor Institution, Shanghai, China. viv-sun@sjtu.edu.cn.)

出处: Cell & bioscience 2022

关键词: Osteosarcoma;Sphingolipid metabolism;Target therapy;Tetraspanin CD151.

摘要: Osteosarcoma is the most common primary bone tumor, with a poor prognosis owing to the lack of efficient molecular-based targeted therapies. Previous ...

作者: Xiaoke Tan  1   2, Xin Zhu  2, Duanjie Xu  1   2, Yanmei Shi  1, Zhenzhen Wang  1, Mingzhuo Cao  1, Kai Hu  1, Lingzhou Zhao  3, Junwei Zhao  4, Mingsan Miao  1, Huahui Zeng  1, Xiangxiang Wu  1 (Affiliations 1 Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine, Zhengzhou, China. 2 Pharmacy College, Henan University of Chinese Medicine, Zhengzhou, China. 3 Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.)

出处: Frontiers in chemistry 2022

关键词: apoptosis;liposome;mitochondria;pancreatic cancer;stachydrine;triptolide.

摘要: Liposome is a conventional drug delivery system which has been widely used in the pharmacy field. However, its applications are greatly restricted in ...

作者: Junjun Liu #  1, Mingyuan Liu #  2, Jiaxuan Feng #  3   4, Hongqiao Zhu  3, Jianlie Wu  1, Heng Zhang  1, Shun Xiao  1, Zaiping Jing  3, Jian Zhou  3, Haitao Niu  5, Mingjin Guo  6 (Affiliations 1 Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China. 2 Department of Vascular Surgery, Beijing Friendship Hospital,Capital Medical University, Beijing, China. 3 Department of Vascular Surgery, The First Affiliated Hospital of the Navy Medical University, Shanghai, China. 4 Intervention Center, Shanghai General Hospital, Affiliated to Medical School of Shanghai Jiaotong University, Shanghai, China. 5 Department of Urology Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China. niuhaitao@qduhospital.cn. 6 Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, Shandong, China. qduahvasc@163.com.)

出处: Journal of translational medicine 2022

关键词: Abdominal aortic aneurysm;Alpha-ketoglutarate;ERK1/2;HOCL;PXDN;ROS.

摘要: Abdominal aortic aneurysm (AAA) represents the serious vascular degenerative disorder, which causes high incidence and mortality. Alpha-ketoglutarate ...

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