作者： Jiaxin Huang  ^{1   2}, Jieru Yang  ², Yuanying Yang  ¹, Xiaofeng Lu  ^{3   4}, Juan Xu  ^{2   3}, Shan Lu  ², Hong Pan  ², Wenhu Zhou  ^{2   5}, Wenqun Li  ¹, Songwen Chen  ³ （Affiliations ¹ Department of Pharmacy, Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China. ² Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, China. ³ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100, Haining Rd, Shanghai, 200080, China. ⁴ Department of Cardiology, Shanghai General Hospital Jiuquan Hospital, No. 22, West St, Jiuquan, Gansu, 735000, China. ⁵ Hunan Key Laboratory of The Research and Development of Novel Pharmaceutical Preparations, School of Pharmaceutical Science, Changsha Medical University, Changsha, Hunan, 410219, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： cGAS‐STING;immunotherapy;mitochondrial dysfunction;nanoparticles;targeting;tumor therapy.

摘要： Doxorubicin (Dox) is a potent chemotherapeutic agent commonly used in cancer treatment. However, cardiotoxicity severely limited its clinical applicat ...

作者： Yangpeng Chen  ¹, Yuhui Hou  ¹, Jiejian Chen  ^{1   2}, Jiaojiao Bai  ^{1   3}, Lijuan Du  ¹, Chen Qiu  ⁴, Hanzhou Qi  ¹, Xuanbei Liu  ¹, Junfei Huang  ¹ （Affiliations ¹ Department of Plastic and Aesthetic Surgery, Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China. ² Department of Medical Oncology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangdong, 510180, China. ³ Department of Haematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, Guangdong, 510030, China. ⁴ Department of Oncology, Shanghai General Hospital, 650 Xinsongjiang Road, Songjiang District, Shanghai, 201620, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： bioengineered hair germ;hair regeneration;microfluidics;mucopolysaccharide;thermodynamic incompatibility.

摘要： Hair follicle (HF) regeneration technology holds promise for treating hair loss, but creating a biomimetic structure that mimics the natural follicle ...

作者： Junyong Ou  ¹, Hai Bi  ², Haobin Zhou  ³, Zhanyi Zhang  ¹, Peichen Duan  ¹, Haoming Yin  ¹, Zezhen Zhou  ¹, Zhixin Xie  ⁴, Xiaojun Tian  ¹, Jianfei Ye  ⁵, Shudong Zhang  ⁵ （Affiliations ¹ Department of Urology, Peking University Third Hospital, Peking University Health Science Center, Beijing, 100191, China. ² Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ The First Clinical College of Guangzhou Medical University, Guangzhou, Guangdong, 511436, China. ⁴ The Second Clinical College of Guangzhou Medical University, Guangzhou, Guangdong, 511436, China. ⁵ Department of Urology, Peking University Third Hospital, Peking University Health Science Center, 49 North Garden Road, Beijing, 100191, China.）

出处： Open medicine (Warsaw, Poland) 2025

关键词： bladder cancer;genome-wide association studies;risk;sex hormone binding globulin;testosterone.

摘要： Background: Males have a three times higher risk of a diagnosis of bladder cancer (Bca) than females. Sex hormone-binding globulin (SHBG) may be assoc ...

作者： Lijuan He  ^{1   2}, Ben Liu  ^{1   2}, Zhuanfang Wang  ^{1   2}, Qinying Han  ^{1   2}, Hao Chen  ^{3   4   5   6   7} （Affiliations ¹ Lanzhou University Second Hospital, Lanzhou, 730030, China. ² Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, 730030, China. ³ Lanzhou University Second Hospital, Lanzhou, 730030, China. ery_chenh@lzu.edu.cn. ⁴ Department of Surgical Oncology, Lanzhou University Second Hospital, Lanzhou, 730030, China. ery_chenh@lzu.edu.cn. ⁵ Gansu Provincial Key Laboratory of Environmental Oncology, Lanzhou, 730030, China. ery_chenh@lzu.edu.cn. ⁶ Humanized animal model laboratory, Lanzhou University Second Hospital, Lanzhou, 730030, China. ery_chenh@lzu.edu.cn. ⁷ Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ery_chenh@lzu.edu.cn.）

出处： Current treatment options in oncology 2025

关键词： Gastric cancer;HER2;Resistance.

摘要： Gastric cancer (GC) is a deadly disease worldwide, and trastuzumab in combination with chemotherapy has been the standard first-line treatment for HER ...

作者： Qinyi Zhang  ¹, Tianhan Xu  ¹, Sihui Yu  ², Sufang Wu  ¹, Ye Yang  ³, Hao Wu  ⁴, Jiawen Zhang  ⁵ （Affiliations ¹ Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China. ³ Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: ye.yang@shgh.cn. ⁴ Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: zhuwy2007@126.com. ⁵ Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Reproductive Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: jwzhang929@163.com.）

出处： Placenta 2025

关键词： DIAGRAM;EGG;FinnGen;Placental weight;Type 2 diabetes.

摘要： Introduction: Placental weight has been associated with various adult-onset diseases, but the causal relationships and underlying mechanisms remain un ...

作者： Yu Du^1,2CA1;Rong Wu²;Xuehong Diao^3,2 （¹ORCID ID: 0000-0001-6909-4357;²Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No 100 Haining Road, Shanghai 200080, China;³ORCID ID: 0000-0001-8234-8331）

出处： Academic Radiology 2025

作者： Shuai He PhD^1,2;Chufeng Gu PhD^3,4,2;Chunren Meng PhD^5,6;Chunyang Cai MS^7,8;Dongwei Lai MS^7,8;Qinghua Qiu MD, PhD⁹CA1,2 （¹School of Life Sciences, Westlake University, Westlake Laboratory of Life Sciences and Biomedicine, Institute of Basic Medical Science, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China;²Contributed equally;³Department of Ophthalmology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, China;⁴Shengli Clinical College of Fujian Medical University, Fuzhou, Fujian, China;⁵Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200011, P. R. China;⁶Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, P. R. China;⁷Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China;⁸National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, PR China;⁹Department of Ophthalmology, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China）

出处： Experimental Cell Research 2025

摘要： Our study aimed to elucidate the mechanism by which circTHADA competitively adsorbs miR-494-3p to regulate CASP1-mediated endothelial cell (EC) pyropt ...

作者： Yaoyao Sun  ^{1   2   3}, Wenfang Zhang  ⁴, Bojie Hu  ⁵, Bin Sun  ⁶, Tonghe Zhang  ⁷, Suqin Yu  ⁸, Gongqiang Yuan  ⁹, Rongping Dai  ¹⁰, Ke Fan  ¹¹, Lifei Wang  ¹², Pei Cheng  ¹³, Gang An  ¹⁴, Liangbao An  ¹⁵, Fang Wang  ¹⁶, Weiqi Chen  ¹⁷, Jie Zhang  ¹⁸, Xiyuan Zhou  ¹⁹, Feng Wang  ²⁰, Jian Ye  ²¹, Xionggao Huang  ²², Xiaoyan Peng  ²³, Jun Li  ²⁴, Miaoqin Wu  ²⁵, Guangming Wan  ²⁶, Jingxiang Zhong  ²⁷, Shaoping Ha  ²⁸, Xiao Ke  ²⁹, Jianhong Liang  ^{1   2   3}, Huijun Qi  ^{1   2   3}, Hong Yin  ^{1   2   3}, Tong Qian  ^{1   2   3}, Jinfeng Qu  ^{1   2   3}, Xuan Shi  ^{1   2   3}, Jing Hou  ^{1   2   3}, Heng Miao  ^{1   2   3}, Yuou Yao  ^{1   2   3}, Enzhong Jin  ^{1   2   3}, Xun Deng  ^{1   2   3}, Jian Zhang  ^{1   2   3}, Xiaoqing Shi  ^{1   2   3}, Jun Liu  ^{1   2   3}, Jie Ma  ^{1   2   3}, Jia Liu  ^{1   2   3}, Ye Tao  ^{1   2   3}, Bin Liu  ^{1   2   3}, Xiaoxin Li  ^{1   2   3}, Mingwei Zhao  ^{1   2   3} （Affiliations ¹ Department of Ophthalmology, Peking University People's Hospital, Beijing, China. ² Beijing Key Laboratory of Ocular Disease and Optometry Science, Beijing, China. ³ College of Optometry, Peking University Health Science Center, Beijing, China. ⁴ Department of Ophthalmology, The Second Hospital of Lanzhou University, Lanzhou, China. ⁵ Tianjin Medical University Eye Hospital, Tianjin, China. ⁶ Department of Ophthalmology, Shanxi Eye Hospital, Taiyuan, Shanxi, People's Republic of China. ⁷ Department of Retina and Vitreous, The Second People's Hospital of Jinan, Jinan, People's Republic of China. ⁸ Department of Ophthalmology, Shanghai General Hospital, Shanghai, China. ⁹ Shandong Eye Hospital, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China. ¹⁰ Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China. ¹¹ Henan Eye Institute, Henan Eye Hospital, Henan Branch of National Clinical Research Center for Ocular Diseases, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China. ¹² Department of Ophthalmology, Hebei Eye Hospital, Xingtai, Hebei, China. ¹³ Department of Ophthalmology, the First Affiliated Hospital of Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. ¹⁴ Department of Ophthalmology, Jinzhou Central Hospital, Jinzhou, China. ¹⁵ Department of Ophthalmology, Shenyang He Eye hospital, Shenyang, China. ¹⁶ Department of Ophthalmology, Shanghai Tenth People's Hospital, Shanghai, China. ¹⁷ Department of Ophthalmology, Xiangguang Chinese University and Shantou International Eye Center, Shantou, China. ¹⁸ Department of Ophthalmology, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, Jiangsu Province, People's Republic of China. ¹⁹ Department of Ophthalmology, The Second Affiliated Hospital of Chongqing University, Chongqing, China. ²⁰ Department of Ophthalmology, Second Affiliated Hospital of Xi 'an Jiaotong University, Xi'an, China. ²¹ Department of Ophthalmology, Chinese People's Liberation Army Army Special Medical zh Center, Chongqing, China. ²² Department of Ophthalmology, Army Specialty Medical Center, Third Military Medical University, Chongqing, China. ²³ Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Tongren Eye Center, Capital Medical University, Haikou, People's Republic of China. ²⁴ Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, Qingdao, Shandong, China. ²⁵ Department of Ophthalmology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Zhejiang, China. ²⁶ Department of Ophthalmology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ²⁷ Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Jieyang, China. ²⁸ Department of Ophthalmology, Ning Xia Eye Hospital, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, China. ²⁹ Medical Research Center, Chengdu Kanghong Biotechnology Inc, Chengdu, Sichuan, China.）

出处： Seminars in ophthalmology 2025

关键词： Conbercept;Intravitreal;Treat-and-extend;neovascular age-related macular degeneration;randomized clinical trial.

摘要： Purpose: To evaluate and contrast the effectiveness and safety of two conbercept treatment protocols-a three-dose treat-and-extend (3+T&E) regimen and ...

作者： Baoji Hu MD^1,2,3,4;Jihong Jiang MD^3,5,4;Wen Pan PhD^6,4;Chun-Shiang Chung PhD³;Chyna Gray PhD³;Yaping Chen BS³;Jianrong Guo MD^1,7CA1;Alfred Ayala PhD³CA2 （¹School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, China;²Department of Anesthesiology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China;³Division of Surgical Research, Department of Surgery, Rhode Island Hospital/ The Warren Alpert School at Medicine at Brown University, Providence, Rhode Island;⁴These authors contributed equally to the article.;⁵Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁶Division of Infectious Diseases, Rhode Island Hospital/ The Warren Alpert Medical School at Brown University, Providence, Rhode Island;⁷Department of Anesthesiology, Shanghai Gongli Hospital, Naval Military Medical University, Shanghai, China）

出处： Journal of Surgical Research 2025

关键词： ARDS;Hem or CLP;NCR;Sepsis;Shock;VISTA

摘要： Introduction Acute respiratory distress syndrome (ARDS) is a life-threatening pulmonary condition with significant mortality, largely due to a lack of ...

作者： Yongjing Li ^{#  1   2}, Ke Chen ^{#  1}, Qin Li  ³, Qiaoli Liu  ¹, Huijie Han  ¹, Hui Liu  ¹, Songpo Wang  ¹ （Affiliations ¹ Department of Traditional Chinese Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Traditional Chinese Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China. ³ Department of Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Frontiers in medicine 2025

关键词： Wnt/β-catenin signaling;caspase-7;chemoresistance;colorectal cancer;traditional Chinese medicine.

摘要： Background: Chemoresistance is a critical factor compromising the survival of patients with colorectal cancer (CRC). The 'Zhi-Zhen' formula (ZZF), a t ...