作者： Chunnan Liu ^{#  1}, Zhaopei Liu ^{#  1}, Kaifeng Jin ^{#  2}, Han Zeng ^{#  3}, Fei Shao  ⁴, Yuan Chang  ¹, Yiwei Wang  ⁵, Le Xu  ⁶, Zewei Wang  ⁷, Yu Zhu  ⁸, Weijuan Zhang  ⁹ （Affiliations ¹ Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China. ² Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, China. ³ Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China. ⁴ Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Urology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China. zwwang12@fudan.edu.cn. ⁸ Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, China. yuzhu10@fudan.edu.cn. ⁹ Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China. weijuanzhang@fudan.edu.cn.）

出处： British journal of cancer 2022

摘要： Background: CD39, a rate-limiting enzyme to convert extracellular ATP (eATP) to adenosine, has been reported to be a key modulator of immune response, ...

作者： Tao Zhang ^{#  1}, Jingjie Li ^{#  2}, Mengkai Yang  ³, Xinglong Ma  ³, Zhuoying Wang  ³, Xiaojun Ma  ³, Mengxiong Sun  ³, Wei Sun  ³, Jing Xu  ³, Yingqi Hua  ⁴, Zhengdong Cai  ⁵ （Affiliations ¹ Department of Orthopedics, Shanghai Bone Tumor Institution, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P. R. China. zhangtaoabc@2008.sina.com. ² Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P. R. China. ³ Department of Orthopedics, Shanghai Bone Tumor Institution, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P. R. China. ⁴ Department of Orthopedics, Shanghai Bone Tumor Institution, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P. R. China. yhua@shsmu.edu.cn. ⁵ Department of Orthopedics, Shanghai Bone Tumor Institution, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P. R. China. caizhengdong@sjtu.edu.cn.）

出处： Oncogene 2022

摘要： Osteosarcoma derives from primitive bone-forming mesenchymal cells and is the most common primary bone malignancy. Therapeutic targeting of osteosarco ...

作者： Tianyi Yuan  ¹, Haidong Zou  ^{2   3   4   5} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. zouhaidong@sjtu.edu.cn. ³ Shanghai Eye Diseases Prevention & Treatment Center, Shanghai Eye Hospital, Shanghai, China. zouhaidong@sjtu.edu.cn. ⁴ National Clinical Research Center for Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. ⁵ Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn.）

出处： Environmental science and pollution research international 2022

关键词： Air pollution;Dopamine;Myopia;Peripheral hyperopia defocus;Retinal ischemia.

摘要： Myopia is one of the most common forms of refractive eye disease and considered as a worldwide pandemic experienced by half of the global population b ...

作者： Jiali Wu  ¹, Xiaodong Sun  ² （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; National Clinical Research Center for Ophthalmic Diseases, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; National Clinical Research Center for Ophthalmic Diseases, Shanghai, China; Shanghai Key Laboratory of Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. Electronic address: xdsun@sjtu.edu.cn.）

出处： Experimental eye research 2022

关键词： Age-related macular degeneration;Ferroptosis;circRNA;miRNA.

摘要： Age-related macular degeneration (AMD) is a leading cause of severe vision impairment in the aging population. However, the underlying molecular mecha ...

作者： Xiaowei Lou  ¹, Ping Zhang  ², Nan Shi  ³, Zhe Ding  ⁴, Zhonggao Xu  ⁵, Bicheng Liu  ⁶, Wenbo Hu  ⁷, Tiekun Yan  ⁸, Jinwen Wang  ⁹, Lin Liu  ¹⁰, Yan Zha  ¹¹, Jianqin Wang  ¹², Wei Chen  ¹³, Chenyun Xu  ¹⁴, Jinsheng Xu  ¹⁵, Hongli Jiang  ¹⁶, Huichao Ma  ¹⁷, Weijie Yuan  ¹⁸, Caili Wang  ¹⁹, Yunhua Liao  ²⁰, Deguang Wang  ²¹, Li Yao  ²², Menghua Chen  ²³, Guisen Li  ²⁴, Yun Li  ²⁵, Pei Wang  ²⁶, Xuemei Li  ²⁷, Chen Lu  ²⁸, Wenzhuang Tang  ²⁹, Jianxin Wan  ³⁰, Rongshan Li  ³¹, Xiangcheng Xiao  ³², Chun Zhang  ³³, Jundong Jiao  ³⁴, Wei Zhang  ³, Jing Yuan  ³, Lan Lan  ³, Jingsong Li  ³⁵, Peng Zhang  ³⁶, Weijun Zheng  ³⁷, Jianghua Chen  ³⁸ （Affiliations ¹ Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China; National Key Clinical Department of Kidney Diseases, PR China; Institute of Nephropathy, Zhejiang University, Hangzhou, PR China; College of Medicine, Zhejiang University, Hangzhou, PR China. ² Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China; National Key Clinical Department of Kidney Diseases, PR China; Institute of Nephropathy, Zhejiang University, Hangzhou, PR China; Zhejiang dialysis quality control center, PR China. ³ Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China; National Key Clinical Department of Kidney Diseases, PR China; Institute of Nephropathy, Zhejiang University, Hangzhou, PR China. ⁴ College of Medicine, Zhejiang University, Hangzhou, PR China. ⁵ First Hospital of Jilin University, PR China. ⁶ Affiliated Zhongda Hospital of Southeast University, PR China. ⁷ Qinghai Provincial Peoples Hospital, PR China. ⁸ Tianjin Medical University General Hospital, PR China. ⁹ Yan'an Hospital of Kunming Medical University, PR China. ¹⁰ Second Affiliated Hospital of Chongqing Medical University, PR China. ¹¹ Guizhou Provincial People's Hospital, PR China. ¹² Second Affiliated Hospital of Lanzhou University, PR China. ¹³ First Affiliated Hospital of Sun yat-sen University, PR China. ¹⁴ Second Affiliated Hospital of Nanchang University, PR China. ¹⁵ Fourth Hospital of Hebei Medical University, PR China. ¹⁶ First Affiliated Hospital of Xian Jiaotong University, PR China. ¹⁷ Second Hospital of Tibet Autonomous Region, PR China. ¹⁸ Shanghai First People's Hospital, PR China. ¹⁹ First Affiliated Hospital of Baotou Medical College, PR China. ²⁰ First Affiliated Hospital of Guangxi Medical University, PR China. ²¹ Second Affiliated Hospital of Anhui Medical University, PR China. ²² First Affiliated Hospital of China Medical University, PR China. ²³ General Hospital of Ningxia Medical University, PR China. ²⁴ Sichuan Provincial Peoples Hospital, PR China. ²⁵ Jiangxi Provincial Peoples Hospital, PR China. ²⁶ First Affiliated Hospital of Zhengzhou University, PR China. ²⁷ Peking Union Medical College Hospital, PR China. ²⁸ Peoples Hospital of Xinjiang Uygur Autonomous Region, PR China. ²⁹ Affiliated Hospital of Hainan Medical College, PR China. ³⁰ First affiliated Hospital of Fujian Medical University, PR China. ³¹ Shanxi Provincial People's Hospital, PR China. ³² Xiangya Hospital Central South University, PR China. ³³ Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, PR China. ³⁴ Second Affiliated Hospital of Harbin Medical University, PR China. ³⁵ Research Center for Healthcare Data Science, Zhejiang Lab, PR China. ³⁶ School of Mathematical Sciences, Zhejiang University, PR China. ³⁷ School of public health, Zhejiang Chinese medical university, Hangzhou, PR China. ³⁸ Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, PR China; National Key Clinical Department of Kidney Diseases, PR China; Institute of Nephropathy, Zhejiang University, Hangzhou, PR China; Zhejiang dialysis quality control center, PR China. Electronic address: chenjianghua@zju.edu.cn.）

出处： The Science of the total environment 2022

关键词： Ambient PM(2.5);Hemodialysis;Mortality;Short-term exposure.

摘要： Background: Long-term exposure to particulate air pollutants can lead to an increase in mortality of hemodialysis patients, but evidence of mortality ...

作者： Zhengyang Zhu  ¹, Chaoyou Fang  ¹, Houshi Xu  ¹, Ling Yuan  ¹, Yichao Du  ¹, Yunjia Ni  ¹, Yuanzhi Xu  ², Anwen Shao  ^{3   4}, Anke Zhang  ^{3   4}, Meiqing Lou  ¹ （Affiliations ¹ Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. ³ Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. ⁴ Department of Neurosurgery, Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, China.）

出处： Frontiers in oncology 2022

关键词： anoikis resistance;apoptosis;glioma;molecular pathways;therapeutic targets.

摘要： Glioma is the most common malignant intracranial tumor and exhibits diffuse metastasis and a high recurrence rate. The invasive property of glioma res ...

作者： Xin Ye ^{#  1   2}, Dan Huang ^{#  1   2}, Zhixia Dong  ^{1   2}, Xiaoxin Wang  ³, Min Ning  ^{1   2}, Jie Xia  ^{1   2}, Shuang Shen  ^{1   2}, Shan Wu  ^{1   2}, Yan Shi  ^{1   2}, Jingjing Wang ^{#  3}, Xinjian Wan ^{#  1   2} （Affiliations ¹ Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai, China. ² Digestive Endoscopic Center, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. ³ Shanghai Key Laboratory of Pancreatic Diseases, Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Microbiology spectrum 2022

关键词： FGF15;FXR;Lactobacillus;bile acid;cholesterol gallstones;gut microbiota.

摘要： Cholesterol gallstone (CGS) disease is characterized by an imbalance in bile acid (BA) metabolism and is closely associated with gut microbiota disord ...

作者： Meiyan Hu ^{#  1   2}, Di Sun ^{#  3}, Jing Yu ^{#  4}, Yue Fu  ¹, Zuoshu Qin  ¹, Baozhu Huang  ¹, Qiuju Zhang  ², Xiong Chen  ², Youheng Wei  ⁵, Huiting Zhu  ⁴, Yue Wang  ⁶, Youji Feng  ¹, Wenxin Zheng  ^{7   8}, Hong Liao  ⁹, Jingjie Li  ¹⁰, Sufang Wu  ¹¹, Zhenbo Zhang  ¹² （Affiliations ¹ Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China. ² Department of Obstetrics and Gynecology, Zhongshan Hospital Wusong Branch, Fudan University, Shanghai, 201900, China. ³ Center for Reproductive Medicine and Fertility Preservation Program, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, China. ⁴ Department of Pathology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 200040, China. ⁵ College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China. ⁶ Department of Obstetrics and Gynecology, Henan Province People's Hospital, Zhengzhou, China. ⁷ Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. ⁸ Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. ⁹ Department of Lab Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 200040, China. ¹⁰ Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China. bristlegrassli@aliyun.com. ¹¹ Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China. wsf_sfph@sjtu.edu.cn. ¹² Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China. zhangzhenbozzb@aliyun.com.）

出处： Laboratory investigation; a journal of technical methods and pathology 2022

摘要： Progestin resistance is the main obstacle for the conservative therapy to maintain fertility in women with endometrial cancer. Brusatol was identified ...

作者： Liren Qian ^{#  1}, Xinxin Xia ^{#  2}, Jiaxin Liu  ³, Xiaoping Chen  ³, Yu Liu  ³, Xiaona Wang  ³, Sabina Iluta  ^{4   5}, Sergiu Pasca  ^{4   5   6}, Diana Gulei  ⁶, Ciprian Tomuleasa  ^{4   5   6} （Affiliations ¹ Department of Hematology, the Fifth Medical Center, Chinese PLA General Hospital, Beijing, China. ² Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Hematology, the Sixth Medical Center, Chinese PLA General Hospital, Beijing, China. ⁴ Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania. ⁵ Department of Hematology, Ion Chiricuta Clinical Cancer Center, Cluj Napoca, Romania. ⁶ Medfuture Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania.）

出处： Annals of translational medicine 2022

作者： Ziqing Yu  ^{1   2}, Zilong Xiao  ^{1   3}, Lichun Guan  ⁴, Pei Bao  ^{1   3}, Yong Yu  ^{1   2}, Yixiu Liang  ¹, Minghui Li  ^{1   2}, Zhenzhen Huang  ¹, Xueying Chen  ¹, Ruizhen Chen  ^{1   2}, Yangang Su  ¹, Junbo Ge  ¹ （Affiliations ¹ Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China. ² Department of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, P. R. China. ³ Graduate School, Shanghai Medical College, Fudan University, Shanghai, P. R. China. ⁴ Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, P. R. China.）

出处： Clinical and translational medicine 2022

关键词： autophagic flux;gasdermin D;inflammation;lipopolysaccharide;mitochondria;mitochondrial membrane potential;mitophagy.

摘要： Backgrounds: Inflammation underlies the mechanism of different kinds of heart disease. Cytoplasmic membrane localized N-terminal fragment of gasdermin ...