作者： Hotin Wu  ^{1   2}, Bo Zhang  ¹, Jun Chen  ¹, Ziyi Qi  ^{1   2}, Xun Xu  ^{1   2}, Huo Li  ³, Xiangui He  ^{4   2} （Affiliations ¹ Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai, China. ³ Department of Electronic Engineering, Tsinghua University, Beijing, China. ⁴ Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China xianhezi@163.com.）

出处： The British journal of ophthalmology 2024

关键词： imaging;optics and refraction.

摘要： Aims: To quantitatively measure retinal curvature (RC) in children with myopia and explore its association with refractive status. Methods: This cross ...

作者： Yaoxin Gao  ¹, Weirong Zhan  ², Dandan Guo  ², Haizhen Lin  ², Muhammad Asad Farooq  ², Chenxu Jin  ², Li Zhang  ², Ying Zhou  ², Jie Yao  ², Yixin Duan  ², Cong He  ³, Shuai Jiang  ⁴, Wenzheng Jiang  ⁵ （Affiliations ¹ Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China; Biotherapy Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China. ² Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China. ³ Laboratory of Cancer Genomics and Biology, Department of Urology and Institute of Translational Medicine. Shanghai General Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁴ State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute Fudan University, Shanghai 200438, China. ⁵ Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China. Electronic address: wzjiang@bio.ecnu.edu.cn.）

出处： Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024

关键词： DCs;GPR97;Keratinocytes;Psoriasis;Th17 cells.

摘要： Skin psoriasis is defined as receiving external stimulation to activate skin dendritic cells (DCs) which can release interleukin 23 (IL-23) to interli ...

作者： Nianting Tong  ^{1   2   3}, Wenying Fan  ^{1   2   4}, Li Su  ^{1   2   5}, Adel Ebraheem  ^{1   2}, Akihito Uji  ^{1   2}, Kenneth Marion  ^{1   2}, Srinivas Sadda  ^{1   2} （Affiliations ¹ Doheny Eye Institute, Los Angeles, California. ² Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California. ³ Department of Ophthalmology, Qingdao Municipal Hospital, Qingdao, China. ⁴ Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China; and. ⁵ Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Retina (Philadelphia, Pa.) 2024

摘要： Purpose: To correlate baseline spectral-domain optical coherence tomography characteristics with the number of as-needed intravitreal injections of ra ...

作者： Shuli Chen  ¹, Xinran Qin  ¹, Yu Sun  ², Zhenlin Ma  ², Chen Niu  ², Yi Xu  ³, Lina Lu  ³, Haidong Zou  ^{1   3   4   5} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Shanghai MicroH Therapeutics, LLC, Shanghai, China. ³ Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. ⁴ Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ⁵ National Clinical Research Center for Eye Diseases, Shanghai, China.）

出处： FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024

关键词： arachidonic acid;diabetes;eicosanoids;epidemiology;high‐fat diet;inflammation;lipoxygenase;p38 MAPK pathway;retina;retinal microvascular endothelial cell.

摘要： 12-hydroxyeicosatetraenoic acid (12-HETE), a major metabolite of arachidonic acid, is converted by 12/15-lipoxygenase and implicated in diabetic retin ...

作者： Xing He  ¹, Haowei He  ¹, Zitong Hou  ¹, Zheyu Wang  ¹, Qinglin Shi  ¹, Tao Zhou  ¹, Yaoxing Wu  ², Yunfei Qin  ³, Jun Wang  ⁴, Zhe Cai  ⁵, Jun Cui  ¹, Shouheng Jin  ⁶ （Affiliations ¹ Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. ² Institute of Precision Medicine, Department of Critical Care Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. ³ Biotherapy Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. ⁴ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. ⁶ Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. jinshh3@mail.sysu.edu.cn.）

出处： The EMBO journal 2024

关键词： Colitis;ER-phagy;Inflammatory Responses;MARK2;UBAC2.

摘要： ER-phagy, a selective form of autophagic degradation of endoplasmic reticulum (ER) fragments, plays an essential role in governing ER homeostasis. Dys ...

作者： Jue Wang  ¹, Xiangshi Sun  ², Zhiwen Zhao  ¹, Guanru Wang  ², Dangge Wang  ³, Yaping Li  ⁴ （Affiliations ¹ State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. ² State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ³ Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: dg_wang@sjtu.edu.cn. ⁴ State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Shandong 264117, China. Electronic address: ypli@simm.ac.cn.）

出处： Journal of controlled release : official journal of the Controlled Release Society 2024

关键词： BRAF(V600E);Colorectal cancer;Copper depletion;Drug resistance;Hydrogel;Nanoparticles.

摘要： BRAF^V600E-mutant colorectal cancer (CRC) is resistant to most first-line therapeutics, including the BRAF inhibitor dabrafenib and epiderma ...

作者： Mengxiao Liang  ¹, Qian Wang  ², Song Zhang  ¹, Qi Lan  ¹, Ruijue Wang  ¹, Echuan Tan  ³, Lei Zhou  ⁴, Changping Wang  ⁴, Hui Wang  ¹, Yiyun Cheng  ³ （Affiliations ¹ South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, South China University of Technology, Guangzhou, 510640, China. ² Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201999, China. ³ Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, China. ⁴ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.）

出处： Advanced materials (Deerfield Beach, Fla.) 2024

关键词： anti‐inflammation;atherosclerosis;autophagy;polypyridiniums;protein delivery.

摘要： Atherosclerosis is a chronic inflammatory disease of the arterial intima and is becoming the leading cause of morbidity and mortality worldwide. There ...

作者： Yanling Zhao ^{#  1}, Han Yan ^{#  2}, Ke Liu ^{#  2}, Jiangping Ma  ², Wenlan Sun  ¹, Hejin Lai  ³, Hongli Li  ¹, Jianbang Gu  ⁴, He Huang  ^{5   6} （Affiliations ¹ Department of Geriatrics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P.R. China. ² Department of Neurology, Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P.R. China. ³ CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. ⁴ Department of Neurology, Shanghai Tenth People's Hospital Chongming Branch, Shanghai, 202150, P.R. China. jiandor36@126.com. ⁵ Department of Neurology, Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, P.R. China. morton162@hotmail.com. ⁶ Department of Neurology, Shanghai Tenth People's Hospital Chongming Branch, Shanghai, 202150, P.R. China. morton162@hotmail.com.）

出处： Molecular medicine (Cambridge, Mass.) 2024

关键词： Acetylcholine receptor β;Aging;Interleukin-6;Myocyte enhancer factor 2 C;Neuromuscular junction;Peroxisome proliferator-activated receptor gamma coactivator 1α.

摘要： Background: Aging-related strength decline contributes to physiological deterioration and is a good predictor of poor prognosis. However, the mechanis ...

作者： Jieyu Ge  ¹, Mengxiang You  ¹, Yu Fan  ², Yong Zhou  ³, Li Jin  ⁴, Guangtao Zhai  ², Fan Liu  ⁵, Sijia Wang  ⁶ （Affiliations ¹ CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. ² School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China. ³ Clinical Research Institute, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ⁴ State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China; Fudan-Taizhou Institute of Health Sciences, Taizhou, China; Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases, Chinese Academy of Medical Sciences(2019RU058), Shanghai, China. ⁵ Department of Forensic Sciences, College of Criminal Justice, Naif Arab University for Security Sciences, Riyadh, Saudi Arabia. ⁶ CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences Kunming Branch, Kunming, Yunnan, China. Electronic address: wangsijia@picb.ac.cn.）

出处： The Journal of investigative dermatology 2024

作者： Wuping Bao  ¹, Yanmei Lin  ¹, Lei Zhao  ¹, Yingying Zhang  ¹, Jingwang Lin  ¹, Junfeng Yin  ², Yiting Wu  ¹, Jifei Wu  ¹, Yan Zhou  ³, Min Zhang  ⁴ （Affiliations ¹ Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² School of Mathematical sciences, Tongji University, Shanghai, China. ³ Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: zhouyan790304@163.com. ⁴ Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: maggie_zhangmin@163.com.）

出处： The journal of allergy and clinical immunology. In practice 2024

关键词： Airway hyperresponsiveness;Asthma;Bronchial provocation;Forced expiratory volume in three seconds;Spirometry.

摘要： Background: Small-airway function assessment is crucial for asthma diagnosis and management. Abnormalities in terminal airflow deserve attention. Obje ...