作者： Yikeng Huang ^{#  1   2   3   4   5}, Xinyu Zhang ^{#  1   2   3   4   5}, Li Liang ^{#  1   2   3   4   5}, Yujin Jiang  ^{1   2   3   4   5}, Bo Li  ^{1   2   3   4   5   6}, Xinyu Zhu  ^{1   2   3   4   5}, Chenxin Li  ^{1   2   3   4   5}, Chufeng Gu  ^{1   2   3   4   5}, Wenjun Zou  ⁷, Zhi Zheng  ^{1   2   3   4   5   8   9}, Shuzhi Zhao  ^{1   2   3   4   5} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² National Clinical Research Centre for Eye Diseases, Shanghai, China. ³ Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. ⁴ Shanghai Engineering Centre for Visual Science and Photomedicine, Shanghai, China. ⁵ Shanghai Engineering Centre for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ⁶ Department of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, China. ⁷ Wuxi No. 2 People's Hospital, Jiangnan University Medical Centre, Wuxi, China. ⁸ Ningde Municipal Hospital of Ningde Normal University, Fujian Medical University, Ningde, China. ⁹ Fujian Medical University, Fuzhou, China.）

出处： Journal of global health 2025

摘要： Background: Recreational screen time (RST) has been found to be associated with cognitive decline and neurodegenerative diseases. However, the associa ...

作者： Dawei Wang  ¹, Feng Shi  ², Dingguo Zhang  ³, Hui Wang  ⁴, Yu Zhu  ¹, Jun Wang  ^{5   6   7} （Affiliations ¹ Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² CAAC East China Aviation Personnel Medical Appraisal Center, Civil Aviation Shanghai Hospital, Shanghai, China. ³ Department of Urology, Shanghai Pudong New Area People's Hospital, Shanghai, China. ⁴ Department of Urology, Shanghai Anting Hospital, Shanghai, China. ⁵ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Urology, Ningde Clinical Medical College of Fujian Medical University, Ningde, China. ⁷ Department of Urology, Ningde Municipal Hospital of Ningde Normal University, Ningde, China.）

出处： Renal failure 2025

关键词： Kidney stones;atherogenic index of plasma;dyslipidemia;nested case-control study.

摘要： Objective: To investigate the association between atherogenic index of plasma (AIP) and risk of incident kidney stones. Methods: A nested case-control ...

作者： Mi Shen^{1,2,3,4,5,6,7};Xinli Ye^{1,2,3,4,5,6,7};Qiang Zhou^{1,2,3,4,5,6,7};Mengru Zheng^{1,2,3,4,5,6,7};Mingzhi Du^{1,2,3,4,5,6,7};Lijuan Wang^1,3,4,5,6,7;Meng Cong^1,3,4,5,6,7;Chang Liu^1,3,4,5,6,7;Chunyan Deng^1,3,4,5,6,7;Zhen Xu^8,3,4,5,6,7;Yu Wang^8,3,4,5,6,7;Jiyu Li^9,3,4,5,6,7;Min Feng^9,3,4,5,6,7;Yujiao Ye^10,3,4,5,6,7;Shuyu Zhang^10,3,4,5,6,7;Wenqing Xu^10,3,4,5,6,7;Yi Lu^10,3,4,5,6,7;Junjie Kong^1,3,4,5,6,7;Jiahuan Gong^1,3,4,5,6,7;Yingjie Xia^10,3,4,5,6,7 （¹Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu, China;²These authors contributed equally to this work.;³Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴The Affiliated Nantong Stomatological Hospital of Nantong University, Nantong, China;⁵Nantong Institute of Genetics and Reproductive Medicine, Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China;⁶Clinical Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China;⁷School of Pharmacy, Nantong University, Nantong, Jiangsu Province, China;⁸Department of Clinical Medical Research Center, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Jiangsu Province, China;⁹Department of Orthopedic Oncology, Second Affiliated Hospital of Naval Medical University, Shanghai, China;¹⁰Medical School of Nantong University, Nantong, Jiangsu, China）

出处： Journal of Biological Chemistry 2025

关键词： skin precursor-derived Schwann cells;extracellular vesicles;peripheral nerve injury;angiogenesis;miR-30a-5p;ANGPT2;LIF

摘要： Ischemia and hypoxia caused by vascular injury intensify nerve damage. Skin precursor-derived Schwann cells have demonstrated an accelerated in vivo p ...

作者： Wenqi Pan¹;Sihui Shao¹;Xinyue Cao²;Xinyue Dai²;Yi Zheng¹;Jingyun Cheng¹;Wei Feng²CA1;Rong Wu¹CA2;Yu Chen²CA3 （¹Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080 Shanghai, P. R. China;²Materdicine Lab, School of Life Sciences, Shanghai University, 200444 Shanghai, P. R. China）

出处： Journal of the American Chemical Society 2025

摘要： The presence of a substantial necrotic core in atherosclerotic plaques markedly heightens the risk of rupture, a consequence of elevated iron levels t ...

作者： Xiaoting Shan  ^{1   2}, Ying Cai  ^{1   2   3}, Binyu Zhu  ^{1   2}, Xujie Sun  ^{1   2}, Lingli Zhou  ¹, Zhiwen Zhao  ^{1   2}, Yaping Li  ^{1   2   3   4}, Dangge Wang  ⁵ （Affiliations ¹ State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. ² University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China. ³ Yantai Key Laboratory of Nanomedicine & Advanced Preparations, Yantai Institute of Materia Medica, Shandong, 264000, China. ⁴ Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, 264000, China. ⁵ Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.）

出处： Advanced healthcare materials 2025

关键词： cancer chemoimmunotherapy;computer‐aided design;nanoparticles;pharmacophore hybridization;triple‐negative breast cancer.

摘要： The rational design of self-assembled compounds is crucial for the highly efficient development of carrier-free nanomedicines. Herein, based on comput ...

作者： Bo Pan ^{#  1   2}, Yiming Pan ^{#  1   2}, Yu-Song Huang ^{#  3}, Meng Yi  ¹, Yuwei Hu  ^{1   2}, Xiaoyu Lian  ^{1   2}, Hui-Zhong Shi  ⁴, Mingwei Wang  ^{1   2}, Guifen Xiang  ^{1   2   5}, Wen-Yi Yang  ⁶, Zhong Liu  ^{7   8   9}, Fangfang Xia  ¹⁰ （Affiliations ¹ Institute of Blood Transfusion Institution, Chinese Academy of Medical Sciences and Peking Union Medical College, 26 Huacai Rd, Longtan Industry Zone, Chenghua District, Chengdu, Sichuan, China. ² Key laboratory of transfusion adverse reactions, Chinese Academy of Medical Sciences, Chengdu, 610052, China. ³ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Haining Rd 100, Shanghai, 200080, China. ⁴ Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China. ⁵ School of Public Health, Anhui Medical University, Hefei, 230032, China. ⁶ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Haining Rd 100, Shanghai, 200080, China. wenyi.yang@shgh.cn. ⁷ Institute of Blood Transfusion Institution, Chinese Academy of Medical Sciences and Peking Union Medical College, 26 Huacai Rd, Longtan Industry Zone, Chenghua District, Chengdu, Sichuan, China. liuz@ibt.pumc.edu.cn. ⁸ Key laboratory of transfusion adverse reactions, Chinese Academy of Medical Sciences, Chengdu, 610052, China. liuz@ibt.pumc.edu.cn. ⁹ School of Public Health, Anhui Medical University, Hefei, 230032, China. liuz@ibt.pumc.edu.cn. ¹⁰ Department of Anesthesiology, the First Affiliated Hospital of Wenzhou Medical University, Zhejiang, China. helenxia4271@163.com.）

出处： BMC psychiatry 2025

关键词： Depression;Geographical region;Meta-analysis;Microbiome–targeted therapy;Patient characteristics;Precision medicine.

摘要： Background: The study aimed to comprehensively analyze and establish a framework for evaluating the efficacy of microbiome-targeted treatment (MTT) fo ...

作者： Yikeng Huang  ¹, Zhi Zheng  ^{1   2   3}, Haibing Chen  ⁴, Chufeng Gu  ⁵ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ² Ningde Municipal Hospital, Ningde Normal University, Ningde, Fujian, China. ³ Fujian Medical University, Fuzhou, Fujian, China. ⁴ Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, China. hbchen@tongji.edu.cn. ⁵ Department of Ophthalmology, Shengli Clinical College of Fujian Medical University; Fuzhou University Affiliated Provincial Hospital, School of Medicine, Fuzhou University, Fuzhou, Fujian, China. guchufeng@fjsl.com.cn.）

出处： Diabetology & metabolic syndrome 2025

关键词： Diabetes inequity;Diabetic nephropathy;Diabetic peripheral neuropathy;Diabetic retinopathy;Socioeconomic status;UK Biobank.

摘要： Background: Prior studies on the link between socioeconomic status (SES) and diabetic microvascular complications have been inconclusive. This study a ...

作者： Yu You ^{#  1   2}, Konglin Huo ^{#  1   2}, Liang He ^{#  2}, Tongyue Wang  ², Lei Zhao  ², Rong Li  ², Xiaoqing Cheng  ¹, Xuebin Ma  ^{1   2}, Zhiying Yue  ³, Stefan Siwko  ⁴, Ning Wang  ^{5   6}, Lujian Liao  ⁷, Mingyao Liu  ⁸, Jian Luo  ⁹ （Affiliations ¹ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, PR China. ² Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, PR China. ³ Precision Research Center for Refractory Diseases, Shanghai General Hospital,Shanghai Jiaotong University, School of Medicine, Shanghai, PR China. ⁴ Department of Translational Medical Sciences, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX, 77030, USA. ⁵ Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, UK. ⁶ Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK. ⁷ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, PR China. ljliao@bio.ecnu.edu.cn. ⁸ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, PR China. myliu@bio.ecnu.edu.cn. ⁹ Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, PR China. jluo@tongji.edu.cn.）

出处： Bone research 2025

摘要： Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstr ...

作者： Linsa Zhou  ¹, Qiang Zhou  ², Qian Guo  ³, Peng Lai  ⁴, Chen Rui  ⁵, Wanqing Li  ⁵, Xuemei Chen  ⁶, Yue Zhuo  ⁶, Xiaoping Zhong  ⁷, Sen Lin  ⁸ （Affiliations ¹ Department of Burns and Plastic Surgery, The Second Affiliated Hospital of Shantou, University Medical College, Shantou, 515000, China. ² Department of Otolaryngology, Ruian People's Hospital), The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, China. zqreadmore@163.com. ³ Department of Otolaryngology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. ⁴ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁵ Department of Otolaryngology, Ruian People's Hospital), The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, China. ⁶ Wenzhou Medical University, Wenzhou, 325027, China. ⁷ Department of Burns and Plastic Surgery, The Second Affiliated Hospital of Shantou, University Medical College, Shantou, 515000, China. zhongxiaoping@stu.edu.cn. ⁸ Department of Otolaryngology, Ruian People's Hospital), The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, China. inns@wmu.edu.cn.）

出处： BMC cancer 2025

关键词： CTSS;Cutaneous melanoma;Immunotherapy;Mendelian randomization;Sensitivity analysis.

摘要： Background: Cutaneous melanoma (CM) is strongly associated with ultraviolet (UV) radiation, which contributes to the transformation of melanocytes int ...

作者： Yizhang Tang  ^{1   2}, Xujiang Yu  ^{3   4}, Liangrui He  ¹, Meng Tang  ⁵, Wenji Yue  ¹, Ruitong Chen  ¹, Jie Zhao  ¹, Qi Pan  ⁶, Wanwan Li  ^{7   8} （Affiliations ¹ State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai, P. R. China. ² Future Material Innovation Center Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University 429 Zhangheng Road, Shanghai, P. R. China. ³ State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai, P. R. China. yuxuj1017@sjtu.edu.cn. ⁴ Future Material Innovation Center Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University 429 Zhangheng Road, Shanghai, P. R. China. yuxuj1017@sjtu.edu.cn. ⁵ Department of Comprehensive Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College 17 Panjiayuan South Lane, Beijing, P. R. China. ⁶ Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine 85 Wujin Road, Shanghai, P. R. China. ⁷ State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai, P. R. China. wwli@sjtu.edu.cn. ⁸ Future Material Innovation Center Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University 429 Zhangheng Road, Shanghai, P. R. China. wwli@sjtu.edu.cn.）

出处： Nature communications 2025

摘要： Reactive oxygen species with evoked immunotherapy holds tremendous promise for cancer treatment but has limitations due to its dependence on exogenous ...