作者： Wei Xiao  ^{1   2}, Yue Zeng  ^{2   3}, Lianzhong Ai  ¹, Guangqiang Wang  ¹, Yang Fu  ^{2   3} （Affiliations ¹ School of Health Science and Engineering, Shanghai Engineering Research Center of Food Microbiology, University of Shanghai for Science and Technology, Shanghai 200093, China. ² Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ³ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.）

出处： Nutrients 2025

关键词： acute pancreatitis;enteral nutrition intolerance;meta-analysis;predictive factors;prevalence.

摘要： Background: Acute pancreatitis (AP) leads to severe inflammation and nutritional deficits, with 80% of severe cases experiencing critical protein loss ...

作者： Qingqing Zhang  ^{1   2}, Fei Li  ^{1   2}, Qichao Ge  ^{1   2}, Yihui Wang  ³, Zhenyang Shen  ^{1   2}, Yuecheng Guo  ^{1   2}, Junjun Wang  ^{1   2}, Hanjing Zhangdi  ^{1   2}, Jingyi Lu  ^{1   2}, Jiaqi Gao  ^{1   2}, Guangwen Chen  ^{1   2}, Qidi Zhang  ^{1   2}, Xingpeng Wang  ^{1   2}, Hui Dong  ^{1   2}, Lungen Lu  ^{1   2} （Affiliations ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： International journal of biological sciences 2025

关键词： MASLD;YBX1;fatty acid translocase CD36;hepatic steatosis;lipid accumulation.

摘要： Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common chronic liver disorder mainly caused by an imbalance in lipid homeostasis ...

作者： Yilin Pan ^{#  1}, Yishu Xue ^{#  1}, Xia Fei ^{#  1}, Lei Zhao ^{#  1}, Lei Han  ¹, Hang Su  ¹, Yanmei Lin  ¹, Yan Zhou  ¹, Yingying Zhang  ¹, Guogang Xie  ¹, Deping Kong  ², Wuping Bao  ¹, Min Zhang  ¹ （Affiliations ¹ Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. ² Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.）

出处： Journal of inflammation research 2025

关键词： PLK1;S1P;T2-high asthma with neutrophilic inflammation;airway smooth muscle cells;volasertib.

摘要： Background: Type 2 (T2)-high asthma with neutrophilic inflammation is characterized by airway eosinophilic and neutrophilic infiltration, hyperrespons ...

作者： Wei Liu  ¹, Kangcheng Zhao  ¹, Feng Chen  ², Chenkai Cai  ³, Tianyuan Jiang  ⁴, Liying Zhu  ⁴, Chunyang Yu  ⁵, Fang Liu  ⁶, Muyu Yu  ⁷ （Affiliations ¹ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ² College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. ³ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁴ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: chunyangyu@sjtu.edu.cn. ⁶ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: f-liu@sjtu.edu.cn. ⁷ Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yumuyu0081@163.com.）

出处： International journal of biological macromolecules 2025

关键词： Bioactive sEVs;Diabetic wound healing;Ferroptosis;Mesenchymal stem cell;Supermolecular hydrogel.

摘要： Poorly-controlled blood glucose frequently develop in diabetic wounds and hydrogel has been reported of great performance for diabetic wound healing. ...

作者： Yinjie Hu ^{#  1}, Xiaolong Tang ^{#  2}, Siwen Li ^{#  3}, Peng Liu  ³, Kaiyong Zhang  ³, Ling Zhao  ⁴, Fangfang Dou  ⁵, Bimeng Zhang  ⁶ （Affiliations ¹ School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 200120, China. ² Shanghai University of Traditional Chinese Medicine, Shanghai, 200120, China. ³ Department of Acupuncture and moxibustion, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁴ School of Acupuncture-Moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai, 200120, China. zl2@shutcm.edu.cn. ⁵ Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200031, China. ff_dou@163.com. ⁶ Department of Acupuncture and moxibustion, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. pjzhtiger08@aliyun.com.）

出处： Cellular and molecular neurobiology 2025

关键词： Electroacupuncture;Hindlimb locomotion;Spinal cord injury;UCN2;cAMP-PKA signaling pathway.

摘要： Spinal cord injury (SCI) has a high mortality and disability rate and can result in severe neurological deficits and complications. The process of SCI ...

作者： Qing Wang^{3 na1};Yushuai Yu^{3 na1};Liqiong Ruan^{4 na1};Mingyao Huang^{3 na1};Wei Chen^{5 na1};Xiaomei Sun⁶;Jun Liu^1,7 & …Zirong Jiang^1,2 （¹Department of Thyroid and Breast Surgery, Ningde Municipal Hospital of Ningde Normal University, Ningde, 352100, China;²Ningde Clinical Medical College of Fujian Medical University, Ningde, 352100, China;³Fujian Medical University, Fuzhou, 350011, China;⁴Department of Clinical Laboratory, Ningde Municipal Hospital of Ningde Normal University, Ningde, 352100, China;⁵Department of Breast Surgery, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, China;⁶Department of Pathology, Ningde Municipal Hospital of Ningde Normal University, Ningde, 352100, China;⁷Department of Breast-Thyroid Surgery, Shanghai General Hospital, Shanghai, 200000, China）

出处： Cancer Cell International 2025

关键词： Macrophages;Large-scale data analysis;Tumor microenvironment;Prognosis

摘要： Background Tumor-associated macrophages (TAMs) are pivotal components of the breast cancer (BC) tumor microenvironment (TME), significantly influenci ...

作者： Zheng-Li Xu  ¹, Yu-Ping Zhang  ², Bao-Dong Ye  ³, Xin Zhao  ¹, Ming Zhou  ², Pei-Hua Lu  ⁴, Zi-Min Sun  ⁵, Xin Li  ⁶, Er-Lie Jiang  ⁷, Dai-Hong Liu  ⁸, Ya-Jing Xu  ⁹, Fang Zhou  ¹⁰, Li Liu  ¹¹, Xi Zhang  ¹², Xian-Min Song  ¹³, Jian-Ping Zhang  ¹⁴, Hai Yi  ¹⁵, Xue-Jun Zhang  ¹⁶, Xue-Hong Ran  ¹⁷, Guo-Hong Su  ¹⁸, Yan-Ming Zhang  ¹⁹, Jie-Ping Chen  ²⁰, Jin-Xiong Huang  ²¹, Chun Wang  ²², Hai-Ping Yang  ²³, Peng-Cheng He  ²⁴, Nan Su  ²⁵, Zi-Wen Guo  ²⁶, Tong Wu  ²⁷, Guan-Chen Bai  ²⁸, Sheng-Jin Fan  ²⁹, Xiao-Jun Huang  ¹, Shun-Qing Wang  ³⁰, Lan-Ping Xu  ³¹ （Affiliations ¹ Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China. ² Guangzhou First People's Hospital, Guangzhou, China. ³ The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China. ⁴ Hebei Yanda Lu Daope Hospital, Langfang, Hebei, China. ⁵ The First Affiliated Hospital of University of Science and Technology of China, Hefei, China. ⁶ The Third Xiangya Hospital of Central South University, Changsha, Hunan, China. ⁷ State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Disease Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical Science & Peking Union Medical College, Tianjin, China. ⁸ General Hospital of PLA (People's Liberation Army of China), Beijing, China. ⁹ Xiangya Hospital of Central South University, Changsha, Hunan, China. ¹⁰ The 960th Hospital of the PLA Joint Logistics Support Force, Jinan, China. ¹¹ Tangdu Hospital Fourth Military Medical University, Xi'an, China. ¹² Xinqiao Hospital of Army Medical University (Third Military Medical University), Chongqing, China. ¹³ Shanghai General Hospital, Shanghai, China. ¹⁴ Beijing Lu Daopei Hospital, Beijing, China. ¹⁵ The General Hospital of Western Theater Command, PLA, Chengdu, China. ¹⁶ The Second Hospital of Hebei Medical University, Hebei, China. ¹⁷ Weifang People's Hospital, Weifang, Shandong, China. ¹⁸ Cangzhou Central Hospital, Cangzhou, Hebei, China. ¹⁹ Huai'an Second People's Hospital, Huai'an, Jiangsu, China. ²⁰ Southwest Hospital, Third Military Medical University, Chongqing, China. ²¹ Liuzhou People's Hospital, Liuzhou, Guangxi, China. ²² Shanghai Zhaxin Traditional Chinese &Western Medicine Hospital, Shanghai, China. ²³ The First Affiliated Hospital of Henan University of Science and Technology, Henan, China. ²⁴ The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. ²⁵ The First Hospital of China Medical University, Shenyang, China. ²⁶ Zhongshan People's Hospital, Guangdong, China. ²⁷ Beijing GoBroad Boren Hospital, Beijing, China. ²⁸ The Affiliated Tai'an City Central Hospital of Qingdao University, Tai'an, Shandong, China. ²⁹ The First Affiliated Hospital of Harbin Medical University, Harbin, China. ³⁰ Guangzhou First People's Hospital, Guangzhou, China. Electronic address: eywangshq@scut.edu.cn. ³¹ Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China. Electronic address: lpxu_0415@sina.com.）

出处： Cancer letters 2025

关键词： Aplastic anemia;haploidentical donor;hematopoietic stem cell transplantation;matched sibling donor.

摘要： Our study includes 278 patients aged between 40 and 50 years from 29 centers who received allogeneic hematopoietic stem cell transplantation (allo-HSC ...

作者： Yun Xie  ¹, Hui Xie  ¹, Rui-Lan Wang  ² （Affiliations ¹ Intensive Care Unit, Shanghai General Hospital, Shanghai 201600, China. ² Intensive Care Unit, Shanghai General Hospital, Shanghai 201600, China. wangyusun@hotmail.com.）

出处： World journal of gastrointestinal surgery 2025

关键词： Critical care;Endoscopic biliary stenting;Liver function;Malignant obstructive jaundice;Palliative care;Quality of life.

摘要： This letter responds to Wang et al's recent publication on endoscopic biliary stenting for malignant obstructive jaundice (MOJ) by offering constructi ...

作者： Jing Ling  ^{1   2}, Siying Wang  ¹, Chenhe Yi  ³, Xingling Zheng  ¹, Yangyang Zhou  ¹, Shunjia Lou  ¹, Haoyu Li  ¹, Ruobing Yu  ¹, Wei Wu  ¹, Qiangxin Wu  ¹, Xiaoxiao Sun  ¹, Yuanyuan Lv  ¹, Huijue Zhu  ¹, Qi Li  ², Haojie Jin  ¹, Jinhong Chen  ³, Jiaojiao Zheng  ¹, Wenxin Qin  ¹ （Affiliations ¹ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, Shanghai, China.）

出处： Hepatology communications 2025

摘要： Background: HCC is one of the most prevalent and deadliest malignancies worldwide, with a poor prognosis. Altered histone modifications have been show ...

作者： Jianxuan Gao  ^{1   2}, Jiali Jin  ², Runzhi Huang  ³, Siqiao Wang  ³, Sihui Song  ², Yu Zhang  ², Yongai Li  ¹, Jun Lin  ⁴, Zhengyan Chang  ⁵, Zongqiang Huang  ⁶, Wei Sun  ¹, Huabin Yin  ¹, Dianwen Song  ¹, Jianru Xiao  ⁷, Ping Wang  ², Tong Meng  ^{1   2} （Affiliations ¹ Department of Orthopedics, Shanghai Bone Tumor Institute, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 201620, P. R. China. ² Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R. China. ³ Department of Orthopedics, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, P. R. China. ⁴ Department of Pathology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 201620, P. R. China. ⁵ Department of Pathology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, P. R. China. ⁶ Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, P. R. China. ⁷ Department of Orthopedics Oncology, Changzheng Hospital, Navy Medical University, Shanghai, 200003, P. R. China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： DUSP12;RAB3B;chordoma;mTORC1 signaling;targeted therapy.

摘要： Chordoma, a rare mesenchymal malignancy, exhibits a high tendency to postoperative recurrence and poor prognosis. To date, its tumorigenic regulatory ...