作者： Tao Zhang  ¹, Suoyuan Li  ², Jingjie Li  ³, Fei Yin  ⁴, Yingqi Hua  ⁴, Zhuoying Wang  ⁴, Hongsheng Wang  ⁴, Dongqing Zuo  ⁴, Jing Xu  ⁴, Zhengdong Cai  ⁵ （Affiliations ¹ Department of Orthopedics, Shanghai Bone Tumor Institution, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. Electronic address: zhangtaoabc@2008.sina.com. ² Department of Orthopedics, Shanghai Bone Tumor Institution, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China; Suzhou Municipal Hospital, Suzhou, PR China. ³ Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. ⁴ Department of Orthopedics, Shanghai Bone Tumor Institution, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. ⁵ Department of Orthopedics, Shanghai Bone Tumor Institution, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. Electronic address: caizhengdong@sjtu.edu.cn.）

出处： Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022

关键词： Metastasis;Osteosarcoma;Pectolinarigenin;SHP-1;STAT3 signaling.

摘要： Signal transducer and activator of transcription 3 (STAT3) plays essential roles in cancer progression and has been considered as a promising target f ...

作者： Lin Ding  ¹, Jie Li  ², Xue Li  ³, Bingqian Qu  ^{4   5} （Affiliations ¹ Department of Cardiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200240, China. ² Department of Basic Medical Sciences & Forensic Medicine, Hangzhou Medical College, Hangzhou 310059, China. ³ Department of Internal Medicine III, University Hospital Heidelberg, 69120 Heidelberg, Germany. ⁴ Department of Veterinary Medicine, Paul Ehrlich Institute, 63225 Langen, Germany. ⁵ European Virus Bioinformatics Center (EVBC), 07743 Jena, Germany.）

出处： Pathogens (Basel, Switzerland) 2022

关键词： H5N8;evolution;high pathogenic avian influenza;human transmission;influenza A virus;mutation;phylogenetic analysis;tMRCA.

摘要： Highly pathogenic influenza A virus H5 subtype remains a risk for transmission in humans. The H5N8 subtype has caused multiple outbreaks in poultry in ...

作者： Yiting Gui  ¹, Yawen Zhang  ¹, Qi Zhang  ², Xudong Chen  ², Feng Wang  ¹, Fang Wu  ³, Yonghao Gui  ⁴, Qiang Li  ⁵ （Affiliations ¹ Translational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect, Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China; Cardiovascular Center, NHC Key Laboratory of Neonatal Diseases, Fudan University, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China. ² Translational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect, Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China. ³ Translational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect, Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China; Department of Neonatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China. ⁴ Translational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect, Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China; Cardiovascular Center, NHC Key Laboratory of Neonatal Diseases, Fudan University, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China. Electronic address: yhgui@fudan.edu.cn. ⁵ Translational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect, Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China. Electronic address: liq@fudan.edu.cn.）

出处： Cells & development 2022

关键词： Cis-regulatory regions;ECR;Fugu;Promoter;TNNI1 (troponin I1);Zebrafish.

摘要： Troponin I type 1b (Tnni1b) is thought to be a novel isoform that is expressed only in the zebrafish heart. Knocking down of tnni1b can lead to cardia ...

作者： Guoliang Wang  ¹, Dan Bing  ², Xinwei Chen  ¹, Pin Dong  ¹ （Affiliations ¹ Department of Otolaryngology Head and Neck Surgery，Nanjing Medical University of Shanghai General Hospital，Shanghai，200080，China. ² Department of Otolaryngology Head and Neck Surgery，Tongji Hospital of Huazhong University of Science and Technology.）

出处： Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 2022

关键词： airway;curved hard tube visual laryngoscope;surgical procedures,operative;vocal cord polyps.

摘要： Objective:To test the feasibility of a rigid curved video laryngoscope in laryngeal microsurgery of patients with difficult laryngeal exposure. Method ...

作者： Yezhe Lin  ¹, Alexander D Zhang  ¹, Ching-Fang Sun  ¹, Justin B White  ¹, Ansi Qi  ¹, Jessica A Farrell  ¹, Robert L Trestman  ¹, Rachel K Martin  ¹, Anita S Kablinger  ¹ （Affiliation ¹ Lin, MD, Sun, MD, White, MD, Farrell, MD, Trestman, MD, Martin, MD, Kablinger, MD, Department of Psychiatry and Behavioral Science, Carilion Clinic-Virginia Tech Carilion School of Medicine, Roanoke, VA, USA; Virginia Tech Carilion School of Medicine, Roanoke, VA, USA. Zhang, BA, Virginia Tech Carilion School of Medicine, Roanoke, VA, USA. Qi, MD, Department of Medical Psychology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.）

出处： Psychopharmacology bulletin 2022

关键词： buprenorphine;mania;psychosis;substance-withdrawal;two-hit hypothesis.

摘要： Buprenorphine and naloxone (Suboxone) is a combination medication-assisted treatment (MAT) for opioid use disorder. MAT withdrawal-induced psychosis i ...

作者： Yiting Gui^1,2,3;Yawen Zhang^1,2,3;Qi Zhang¹;Xudong Chen¹;Feng Wang^1,2;Fang Wu⁴;Yonghao Gui²CA1;Qiang Li¹CA2 （¹Translational Medical Center for Development and Disease, Shanghai Key Laboratory of Birth Defect Prevention and Control, NHC Key Laboratory of Neonatal Diseases, Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China;²Cardiovascular Center, NHC Key Laboratory of Neonatal Diseases, Fudan University, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China;³These authors contributed equally to this work.;⁴Department of Neonatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China）

出处： Cells & Development 2022

关键词： Cis-regulatory regions;Promoter;Fugu;ECR;TNNI1 (troponin I1);Zebrafish

摘要： Troponin I type 1b (Tnni1b) is thought to be a novel isoform that is expressed only in the zebrafish heart. Knocking down of tnni1b can lead to cardia ...

作者： Xiaomin Xu¹;Zongshan Li²;Huirong Zuo³;Huimin Chen²;Yaxing Gui^1,2CA1 （¹Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China;²Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;³Department of Rehabilitation Medicine, Haining Kanghua Hospital, Jiaxing, Zhejiang 314419, China）

出处： Neuroscience Letters 2022

关键词： Exosomes;Cholesterol;Lipid raft;Parkinson’s disease

摘要： Parkinson’s disease (PD) is associated with abnormal metabolism of brain cholesterol, and the metabolites of neuronal cholesterol may also affect neur ...

作者： Chencheng Yao;Dong Hou;Zhiyong Ji;Dongmei Pang;Peng Li;Ruhui Tian;Yuxiang Zhang;Ningjing Ou;Haowei Bai;Erlei Zhi;Yuhua Huang;Yingying Qin;Jingpeng Zhao;Chenchen Wang;Zhi Zhou;Ting Guo;Zheng Li （Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Jimo Hospital of Traditional Chinese Medicine Affiliated to Shandong University of Traditional Chinese Medicine, Qingdao, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Shanghai Advanced Research Institute, Stem Cell and Reproductive Biology Laboratory, Chinese Academy of Sciences, Shanghai, China School of Life Science and Technology, ShanghaiTech University, Shanghai, China Zhi Zhou, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Ting Guo, Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250012, China. Zheng Li, Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan, China Zhi Zhou, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Ting Guo, Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250012, China. Zheng Li, Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China Zhi Zhou, School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. Ting Guo, Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan 250012, China. Zheng Li, Department of Andrology, Center for Men's Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.）

出处： Clinical Genetics 2022

关键词： gene variants;meiosis;NOA;POI;SPATA22

摘要： The genetic causes of idiopathic premature ovarian insufficiency (POI) and nonobstructive azoospermia (NOA) remain unclear. We performed whole-exome s ...

作者： Kailei Shi MD^1,2,3;Ren Anmin MD^1,3;Junfeng Cai MD^4,3;Yiding Qi MD¹;Wanlin Han MD¹;Mingxuan Li MD¹;Guannan Zhang MD⁵;Shuyi Zhang MD¹;Lei Fu MD²;Wenzheng Han MD¹;Shaofeng Guan MD¹;Jun Li MD⁶;Lin Qi MD⁶;Lei Lin MD⁶;Xinkai Qu MD¹CA1;Maoqing Ye MD, PhD^1,2CA2 （¹Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China;²Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, China;³Kailei Shi, Ren Anmin, and Junfeng Cai contributed equally.;⁴Department of Cardiovascular Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China;⁵Department of Immunology, Key Laboratory of Immune Microenvironment and Disease, Nanjing Medical University, Nanjing, Jiangsu, China;⁶Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Journal of Cardiology 2022

关键词： Ascending aortic perivascular adipose tissue;Aortic valve disease;Transcriptome;Inflammation

摘要： Background Ascending aortic perivascular adipose tissue (AA-PVAT) mainly comprises brown adipose tissue (BAT), originates from neural crest cells tha ...

作者： Yuanzheng Zheng;Saihua Huang;Jialing Zhang;Jia Hou;Fang Wu;Wenji Wang;Xiao Han;Yonghao Gui （Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Fudan University, Shanghai, China Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Department of Clinical Immunology, Children's Hospital of Fudan University, Shanghai, China Department of Neonatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, Fudan University, Shanghai, China Xiao Han and Yonghao Gui, National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, 399 Wanyuan Road, Minhang, Shanghai, 201102, China. Cardiovascular Center, Children's Hospital of Fudan University, Shanghai, China National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China Xiao Han and Yonghao Gui, National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, 399 Wanyuan Road, Minhang, Shanghai, 201102, China.）

出处： Cell Proliferation 2022

摘要： Objectives Melatonin has been reported to be an appropriate candidate for mitigating various cardiovascular injuries, owing to its versatility. This s ...