作者： Ya Zhao  ¹, Jingyue Zhang  ², Jiao Xia  ¹, Xiaoyan Han  ³, Shuai Ben  ¹, Tianyi Liu  ⁴, Wan Mu  ³, Mudi Yao  ¹, Qin Jiang  ⁵, Biao Yan  ⁶ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210029, China. ³ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200030, China. ⁴ Department of Ophthalmology, The Second Affiliated Hospital of Nantong University, Nantong, 226000, China. ⁵ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210029, China. Electronic address: Jiangqin710@126.com. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: yanbiao@sjtu.edu.cn.）

出处： Biochemical and biophysical research communications 2025

关键词： Biomarkers;Glycerophospholipid metabolism;Metabolomics;Vascular aging.

摘要： Vascular aging contributes to the morbidity and mortality in older individuals, closely linked to an imbalance between energy consumption and producti ...

作者： Huixun Jia  ^{1   2}, Xiaodong Sun  ^{1   2} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² National Clinical Research Center for Eye Diseases, Shanghai, China.）

出处： JAMA ophthalmology 2025

作者： Guoqing Lyu  ^{1   2   3   4}, Lihua Dai  ⁵, Xin Deng  ⁶, Xiankai Liu  ^{1   3   4}, Yan Guo  ^{1   3   4}, Yuan Zhang  ^{1   3   4}, Xiufeng Wang  ^{1   3   4}, Yan Huang  ^{1   3   4}, Sun Wu  ^{1   3   4}, Jin-Cheng Guo  ⁶, Yanting Liu  ^{1   7} （Affiliations ¹ Department of Hematology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China. ² Life Science Center, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China. ³ Key Laboratory for Leukemia Molecular Diagnosis and Treatment in Xinxiang City, Weihui, Henan Province, China. ⁴ Key Laboratory for Lymphoma Molecular Diagnosis and Treatment in Xinxiang City, Weihui, Henan Province, China. ⁵ Prenatal Diagnosis Center, Shanghai General Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, China. ⁶ Beijing University of Chinese Medicine, Beijing, China. ⁷ Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan Province, China.）

出处： Journal of cellular and molecular medicine 2025

关键词： cuproptosis;mitochondrial depolarisation;non‐small cell lung cancer;prognostic model;tumour marker.

摘要： In this research, we conducted an in-depth analysis of differentially expressed genes associated with mitochondrial depolarisation in non-small cell l ...

作者： Songshan Shi  ¹, Jiamin Liu  ², Yanting Gao  ³, Xinghuai Sun  ², Weihao Chen  ¹, Weiran Zhang  ⁴, Huijun Wang  ⁵, Shunchun Wang  ⁶, Yuan Lei  ⁷ （Affiliations ¹ The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. ² Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai 200031, China. ³ Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University, 85 Wujin Road, Shanghai 200080, China. ⁴ School of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. ⁵ The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: wanghj@shutcm.edu.cn. ⁶ The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address: shunchunwang@126.com. ⁷ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, Shanghai 200031, China; Institute of Occupational Health and Environmental Health, School of Public Health, Lanzhou University, Lanzhou 730000, Gansu, China. Electronic address: yuan_lei@fudan.edu.cn.）

出处： International journal of biological macromolecules 2025

关键词： Grateloupia filicina;High intraocular pressure;Ocular inflammation;PM(2.5);Pyroptosis;κ-Carrageenan.

摘要： This study investigates the efficacy of GFP01, an almost pure κ-carrageenan derived from Grateloupia filicina, in counteracting intraocular pressure ( ...

作者： Huajun Xu  ¹, Yupu Liu  ¹, Chenyang Li  ², Xinyi Li  ¹, Li Shen  ³, Hui Wang  ⁴, Feng Liu  ¹, Juanjuan Zou  ⁵, Yunyan Xia  ⁶, Weijun Huang  ², Yuenan Liu  ¹, Zhenfei Gao  ¹, Yiqun Fu  ⁴, Fan Wang  ⁴, Shujian Huang  ⁴, Zhiyuan Song  ⁷, Fan Song  ⁸, Yiqing Gao  ⁴, Yu Peng  ², Jianyin Zou  ⁹, Huaming Zhu  ¹⁰, Suru Liu  ⁴, Linpeng Li  ⁴, Xiaoyue Zhu  ², Yuanping Xiong  ⁶, Yuli Hu  ¹¹, Jiaxin Yang  ¹¹, Yuehua Li  ¹², Feng Gao  ¹³, Qihao Guo  ¹⁴, Hengye Huang  ¹⁵, Weituo Zhang  ¹⁶, Jiping Li  ¹⁷, Yanqing Chen  ¹⁸, Pin Dong  ⁸, Jun Yang  ¹⁹, Jingrong Lv  ¹⁹, Peihua Wang  ²⁰, Yiyuan Sun  ²⁰, Biyun Qian  ²¹, Kristine Yaffe  ²², Jian Guan  ²³, Hongliang Yi  ²⁴, Yue Leng  ²⁵, Shankai Yin  ²⁶ （Affiliations ¹ Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Department of Otolaryngology Head and Neck Surgery and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China. ² Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, shanghai, China. ³ Clinical Research Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Otolaryngology-Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai , China. ⁵ Department of Otorhinolaryngology and National Health Commission (NHC) Key Laboratory of Otorhinolaryngology, Shandong University Affiliated Qilu Hospital, Jinan, China. ⁶ Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Jiangxi, China. ⁷ Department of Otolaryngology Head and Neck Surgery, Huashan Hospital, Fudan University, Shanghai, China. ⁸ Department of Otolaryngology, Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁹ Department of Otolaryngology-Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁰ Therapy Center for Obstructive Sleep Apnea, Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. ¹¹ Nursing Department of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹² Department of Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹³ Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁴ Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁵ Department of Epidemiology, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁶ Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁷ Department of Otorhinolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Jinan, China. ¹⁸ Department of Otorhinolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. ¹⁹ Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ²⁰ Department of Otorhinolaryngology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ²¹ Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ²² University of California, San Francisco, Departments of Psychiatry, Neurology, and Epidemiology, San Francisco, California, United States. ²³ Otolaryngology Institute of Shanghai Jiao Tong University, Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital,, Shanghai, China. ²⁴ Otolaryngology Institute of Shanghai Jiao Tong University, Department of Otolaryngology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. ²⁵ Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, United States. ²⁶ Otolaryngology Institute, Shanghai Jiao Tong University, Department of Otolaryngology, Affiliated Sixth People's Hospital, Shanghai, China; skyin@sjtu.edu.cn.）

出处： American journal of respiratory and critical care medicine 2025

关键词： CPAP;MoCA performance;neuroimaging biomarkers;sleep apnea.

摘要： Rationale: Obstructive sleep apnea (OSA) is associated with cognitive impairment. The effects of continuous positive airway pressure (CPAP) on neuroim ...

作者： Mengyu Tao  ¹, Wenting Liu  ^{2   3}, Jianhua Chen  ^{2   3}, Rujiao Liu  ^{2   3}, Jianling Zou  ^{2   3}, Bo Yu  ^{2   3}, Chenchen Wang  ^{2   3}, Mingzhu Huang  ^{2   3}, Qingjian Chen  ¹, Zhe Zhang  ^{2   3}, Zhiyu Chen  ^{2   3}, Haoyu Sun  ^{2   3   4}, Cheng Zhou  ⁵, Shuguang Tan  ⁶, Yuxuan Zheng  ⁷, Hongxia Wang  ^{2   3} （Affiliations ¹ Department of Oncology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200800, P. R. China. ² Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P. R. China. ³ Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China. ⁴ Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. ⁵ Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China. ⁶ The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China. ⁷ Human Phenome Institute, Minhang Hosptial, Fudan University, Shanghai, 201203, P. R. China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： AP‐1 family;CAF;CDCP1;PDAC;heterogeneity.

摘要： Cancer-associated fibroblasts (CAFs) play a crucial role in the progression of pancreatic ductal adenocarcinoma (PDAC). Here, integrated single-cell R ...

作者： Haihong Zhu  ^{1   2}, Liping Ouyang  ^{2   3}, Yangguang Huang  ², Ji Tan  ⁴, Chunyu Liu  ⁵, Qian Wang  ², Rongkun Huang  ², Wing Tak Wong  ⁶, Xuanyong Liu  ^{4   7}, Haobo Pan  ⁵, Yun Liao  ^{1   2} （Affiliations ¹ Department of Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. ³ Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. ⁴ State Key Laboratory of Advanced Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China. ⁵ Shenzhen Key Laboratory of Marine Biomedical Materials, CAS-HK Joint Lab of Biomaterials, The Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. ⁶ School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, 999077, China. ⁷ School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Sub-Lane Xiangshan, Hangzhou, 310024, China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词： TRPV2;borate glass;calcium overload;precise breast cancer treatment;ultrasound.

摘要： Effective and precise treatment of breast cancer, particularly with bone metastasis, remains a significant challenge. Here, a dual-gating strategy com ...

作者： Junjun Xiong ^{#  1}, Xuhui Ge ^{#  1   2   3}, Dishui Pan ^{#  1}, Yufeng Zhu  ¹, Yitong Zhou  ¹, Yu Gao  ¹, Haofan Wang  ¹, Xiaokun Wang  ¹, Yao Gu  ¹, Wu Ye  ¹, Honglin Teng  ⁴, Xuhui Zhou  ^{5   6   7}, Zheng Wang  ⁸, Wei Liu  ^{9   10   11}, Weihua Cai  ¹² （Affiliations ¹ Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. ² Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, China. ³ Department of Stress Medicine, Faculty of Psychology, Naval Medical University, Shanghai, China. ⁴ Department of Orthopedics (Spine Surgery), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. ⁵ Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, China. zhouxuhui@smmu.edu.cn. ⁶ Department of Stress Medicine, Faculty of Psychology, Naval Medical University, Shanghai, China. zhouxuhui@smmu.edu.cn. ⁷ Translational Research Centre of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhouxuhui@smmu.edu.cn. ⁸ Department of Orthopedics, Chinese PLA General Hospital, Beijing, China. wangzheng301@163.com. ⁹ Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. liuweiorth@njmu.edu.cn. ¹⁰ Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, China. liuweiorth@njmu.edu.cn. ¹¹ Department of Stress Medicine, Faculty of Psychology, Naval Medical University, Shanghai, China. liuweiorth@njmu.edu.cn. ¹² Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. caiwhspine@njmu.edu.cn.）

出处： Cell death and differentiation 2025

摘要： Astrocytic metabolic reprogramming is an adaptation of metabolic patterns to meet increased energy demands, although the role after spinal cord injury ...

作者： Xie, Yun^a;Wang, Ruilan^aCAa （^aDepartment of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, China）

出处： American Journal of Respiratory and Critical Care Medicine 2025

作者： Xie, Yihui^a;Shi, Weimin^b;Yin, Wenhao^aCAa;Mei, Xingyu^bCAb （^aDepartment of Dermatology, The Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Zhejiang, Jiaxing, China;^bDepartment of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Journal of Cosmetic Dermatology 2025

关键词： 2940 erbium laser;308 nm excimer light;vitiligo

摘要： Background: A 308 nm excimer light is an effective treatment for vitiligo, with fewer treatment times, rapid obvious effects, relatively complete pigm ...