作者： Fei Shi;Changqing Yang;Qingxin Jiang;Weifang Zhu;Xun Xu;Xinjian Chen;Ying Fan （Affiliations ¹ Electronics and Information Engineering, Soochow University, 1 Shizi Street, Suzhou, 215006, CHINA. ² Soochow University, 1 Shizi Street, Suzhou, Jiangsu, 215006, CHINA. ³ Shanghai General Hospital, No. 100 Haining Road, Shanghai, 200080, CHINA.）

出处： Physics in medicine and biology 2023

关键词： Deep learning;Multi-class segmentation;OCT image;Retinal detachment;Retinoschisis.

摘要： Retinal detachment (RD) and retinoschisis (RS) are the main complications leading to vision loss in high myopia. Accurate segmentation of RD and RS, i ...

作者： Hanhao Dai  ¹, Jun Luo  ², Lili Deng  ³, Chao Song  ¹, Zhibo Deng  ¹, Yijing Wu  ¹, Song Gu  ⁴, Jie Xu  ^{1   2} （Affiliations ¹ Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China. ² Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350000, China. ³ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China. ⁴ Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.）

出处： Advanced healthcare materials 2023

关键词： Extracellular vesicle;MicroRNA;Myogenesis;Sarcopenia;Stemness.

摘要： Sarcopenia is a geriatric disease characterized by reduced muscle function and mass. The capacity to self-renew and myogenesis of satellite cells (SCs ...

作者： Yi Zheng¹;Jing Chen¹;Xin-Ran Song²;Mei-Qi Chang³;Wei Feng²;Hui Huang²;Cai-Xia Jia¹;Li Ding⁴CA1;Yu Chen²CA2;Rong Wu¹CA3 （¹Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China;²Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China;³Central Laboratory of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, PR China;⁴Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Tongji University School of Medicine, Tongji University, Shanghai, 200070, PR China）

出处： Biomaterials 2023

关键词： Antitumor immunotherapy;Innate immunity;Manganese;Synergistic therapy;cGAS-STING pathway

摘要： As the clinical efficacy of immunotherapy for triple-negative breast cancer (TNBC) remains limited, exploring new immunotherapy approaches is still in ...

作者： Senmiao Zhu^1,2,3,4;Lili Chen^1,2,4;Min Wang^1,2,3,4;Jing Zhang²;Gang Chen²;Yinghao Yao⁵;Shihan Song^1,2;Tong Li²;Shenglan Xu²;Zhonghao Yu^1,2;Bingyan Shen^1,2;Duogang Xu⁶;Zai-Long Chi^1,2CA1;Wencan Wu^1,2,3CA2 （¹National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China;²State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China;³Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang 325000, China;⁴These authors contributed equally to this work.;⁵Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325027, China;⁶Department of General Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China）

出处： Journal of Controlled Release 2023

关键词： Schwann cells;Optic neuropathy;Small extracellular vesicles;Natural biomaterials;Retinal ganglion cells;CREB signaling pathway

摘要： Optic neuropathy is the leading cause of irreversible blindness and is characterized by progressive degeneration of retinal ganglion cells (RGCs). Sev ...

作者： Yaying Sun ^{#  1}, Zhiwen Luo ^{#  1}, Yisheng Chen ^{#  1}, Jinrong Lin  ¹, Yuhan Zhang  ¹, Beijie Qi  ¹, Jiwu Chen  ² （Affiliations ¹ Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China. ² Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. jeevechen@163.com.）

出处： Biomaterials research 2022

关键词： Adhesive capsulitis;Circulating exosomes;Liposomes;Rotator cuff tear;miRNAs.

摘要： Background: Adhesive capsulitis is a common shoulder disorder inducing joint capsule fibrosis and pain. When combined with rotator cuff tear (RCT), tr ...

作者： C R Wang  ¹, M Kang  ², J Xu  ¹, Y Lyu  ¹, Y F Jiang  ¹, M X Sun  ¹, D Q Zuo  ¹, J K Shen  ¹, X J Ma  ¹, W Sun  ¹, Y Q Hua  ², Zhengdong Cai  ¹ （Affiliations ¹ Department of Bone Tumor, Shanghai General Hospital, Shanghai 200080, China. ² Department of Bone Tumor, Shanghai General Hospital, Shanghai 200080, China Shanghai Cell Therapy Clinical Transformation Engineering Technology Research Center, Shanghai 200080, China.）

出处： Zhonghua yi xue za zhi 2022

摘要： Objective: To explore the safety and efficacy of tumor-infiltrating lymphocytes (TILs) extracted from tumor tissue in patients with pulmonary metastas ...

作者： Tianyu Qin ^{#  1   2}, Junpeng Fan ^{#  1   2}, Funian Lu  ^{1   2}, Li Zhang  ^{1   2}, Chen Liu  ^{1   2   3}, Qiyue Xiong  ^{1   2}, Yang Zhao  ⁴, Gang Chen  ^{5   6}, Chaoyang Sun  ^{7   8} （Affiliations ¹ Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Research building of Tongji Hospital, No.2 Jiankang Avenue, Caidian Street, Caidian District, Wuhan, 430030, China. ² Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. ³ Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai, 200000, China. ⁴ Department of Plastic Cosmetic and Burn Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 442008, China. ⁵ Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Research building of Tongji Hospital, No.2 Jiankang Avenue, Caidian Street, Caidian District, Wuhan, 430030, China. gumpc@126.com. ⁶ Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. gumpc@126.com. ⁷ Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Research building of Tongji Hospital, No.2 Jiankang Avenue, Caidian Street, Caidian District, Wuhan, 430030, China. suncydoctor@gmail.com. ⁸ Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. suncydoctor@gmail.com.）

出处： Journal of experimental & clinical cancer research : CR 2022

关键词： Genetically engineered mouse models;Ovarian cancer;Patient-derived organoids;Patient-derived xenograft;Personalised medicine;Preclinical models

摘要： Ovarian cancer (OC) is a heterogeneous malignancy with various etiology, histopathology, and biological feature. Despite accumulating understanding of ...

作者： H D Zou  ¹, L N Lu  ¹, Y Xu  ¹, S L Lin  ¹ （Affiliation ¹ Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Division of Ophthalmology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 200040, China.）

出处： [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2022

摘要： Due to factors such as medical resources, public awareness, funding for general screening, or optimized screening models, community-based screening is ...

作者： T Li  ¹, C H Yang  ², H D Zou  ¹ （Affiliations ¹ Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Division of Ophthalmology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 200040, China. ² The Pediatric Hospital Affiliated to Fudan University, Shanghai 201102, China.）

出处： [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2022

摘要： Two adolescents with T1DM participated in the Shanghai Children and Adolescent DM Eye study (SCADE) 2017-2018. The previous T1DM history of the 2 chil ...

作者： Björn Hegner  ^{1   2}, Tobias Kretzschmar  ³, Nan Zhu  ^{1   4}, Gunnar Kleinau  ⁵, Hongfan Zhao  ¹, Julian Kamhieh-Milz  ⁶, Julia Hilger  ⁷, Ralf Schindler  ^{1   8}, Patrick Scheerer  ^{5   9}, Gabriela Riemekasten  ¹⁰, Aurélie Philippe  ^{1   11}, Rusan Catar  ¹ （Affiliations ¹ Department of Nephrology and Critical Care Medicine, Campus Virchow Klinikum, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ² Vitanas Hospital for Geriatric Medicine, Berlin, Germany. ³ Department of Internal Medicine Emergency Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ⁴ Shanghai general hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. ⁵ Institute of Medical Physics and Biophysics, Group Protein X-ray Crystallography and Signal Transduction, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ⁶ Department of Transfusion Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ⁷ Department of Rheumatology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. ⁸ Nierenzentrum Zehlendorf, Berlin, Germany. ⁹ DZHK (German Centre for Cardiovascular Research), partner site Berlin. ¹⁰ Department of Rheumatology and Clinical Immunology, Universitätsklinikum Schleswig-Holstein, Lübeck, Germany. ¹¹ BIH Biomedical Innovation Academy, Berlin Institute of Health at Charité - Universitätsmedizin Berlin (BIH), Berlin, Germany.）

出处： Rheumatology (Oxford, England) 2022

关键词： G-protein coupled receptors;Scleroderma renal crisis;agonistic autoantibodies;receptor hypersensitization

摘要： Objectives: Scleroderma renal crisis (SRC) is a rare vascular complication of systemic sclerosis with substantial risks for end-stage renal disease an ...