作者： Yikeng Huang  ¹, Zhi Zheng  ^{1   2   3}, Haibing Chen  ⁴, Chufeng Gu  ⁵ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ² Ningde Municipal Hospital, Ningde Normal University, Ningde, Fujian, China. ³ Fujian Medical University, Fuzhou, Fujian, China. ⁴ Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, China. hbchen@tongji.edu.cn. ⁵ Department of Ophthalmology, Shengli Clinical College of Fujian Medical University; Fuzhou University Affiliated Provincial Hospital, School of Medicine, Fuzhou University, Fuzhou, Fujian, China. guchufeng@fjsl.com.cn.）

出处： Diabetology & metabolic syndrome 2025

关键词： Diabetes inequity;Diabetic nephropathy;Diabetic peripheral neuropathy;Diabetic retinopathy;Socioeconomic status;UK Biobank.

摘要： Background: Prior studies on the link between socioeconomic status (SES) and diabetic microvascular complications have been inconclusive. This study a ...

作者： Yu You ^{#  1   2}, Konglin Huo ^{#  1   2}, Liang He ^{#  2}, Tongyue Wang  ², Lei Zhao  ², Rong Li  ², Xiaoqing Cheng  ¹, Xuebin Ma  ^{1   2}, Zhiying Yue  ³, Stefan Siwko  ⁴, Ning Wang  ^{5   6}, Lujian Liao  ⁷, Mingyao Liu  ⁸, Jian Luo  ⁹ （Affiliations ¹ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, PR China. ² Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, PR China. ³ Precision Research Center for Refractory Diseases, Shanghai General Hospital,Shanghai Jiaotong University, School of Medicine, Shanghai, PR China. ⁴ Department of Translational Medical Sciences, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX, 77030, USA. ⁵ Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Leicester, UK. ⁶ Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK. ⁷ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, PR China. ljliao@bio.ecnu.edu.cn. ⁸ Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, PR China. myliu@bio.ecnu.edu.cn. ⁹ Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, PR China. jluo@tongji.edu.cn.）

出处： Bone research 2025

摘要： Reproductive hormones associated with the hypothalamic-pituitary-gonadal (HPG) axis are closely linked to bone homeostasis. In this study, we demonstr ...

作者： Linsa Zhou  ¹, Qiang Zhou  ², Qian Guo  ³, Peng Lai  ⁴, Chen Rui  ⁵, Wanqing Li  ⁵, Xuemei Chen  ⁶, Yue Zhuo  ⁶, Xiaoping Zhong  ⁷, Sen Lin  ⁸ （Affiliations ¹ Department of Burns and Plastic Surgery, The Second Affiliated Hospital of Shantou, University Medical College, Shantou, 515000, China. ² Department of Otolaryngology, Ruian People's Hospital), The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, China. zqreadmore@163.com. ³ Department of Otolaryngology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. ⁴ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁵ Department of Otolaryngology, Ruian People's Hospital), The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, China. ⁶ Wenzhou Medical University, Wenzhou, 325027, China. ⁷ Department of Burns and Plastic Surgery, The Second Affiliated Hospital of Shantou, University Medical College, Shantou, 515000, China. zhongxiaoping@stu.edu.cn. ⁸ Department of Otolaryngology, Ruian People's Hospital), The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, China. inns@wmu.edu.cn.）

出处： BMC cancer 2025

关键词： CTSS;Cutaneous melanoma;Immunotherapy;Mendelian randomization;Sensitivity analysis.

摘要： Background: Cutaneous melanoma (CM) is strongly associated with ultraviolet (UV) radiation, which contributes to the transformation of melanocytes int ...

作者： Yizhang Tang  ^{1   2}, Xujiang Yu  ^{3   4}, Liangrui He  ¹, Meng Tang  ⁵, Wenji Yue  ¹, Ruitong Chen  ¹, Jie Zhao  ¹, Qi Pan  ⁶, Wanwan Li  ^{7   8} （Affiliations ¹ State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai, P. R. China. ² Future Material Innovation Center Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University 429 Zhangheng Road, Shanghai, P. R. China. ³ State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai, P. R. China. yuxuj1017@sjtu.edu.cn. ⁴ Future Material Innovation Center Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University 429 Zhangheng Road, Shanghai, P. R. China. yuxuj1017@sjtu.edu.cn. ⁵ Department of Comprehensive Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College 17 Panjiayuan South Lane, Beijing, P. R. China. ⁶ Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine 85 Wujin Road, Shanghai, P. R. China. ⁷ State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University 800 Dongchuan Road, Shanghai, P. R. China. wwli@sjtu.edu.cn. ⁸ Future Material Innovation Center Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University 429 Zhangheng Road, Shanghai, P. R. China. wwli@sjtu.edu.cn.）

出处： Nature communications 2025

摘要： Reactive oxygen species with evoked immunotherapy holds tremendous promise for cancer treatment but has limitations due to its dependence on exogenous ...

作者： Zhipeng Zhang  ¹, Mengzhu Liu  ², Yangyun Wang  ³, Peng Wu  ⁴, Yiping Zhu  ⁵, Bangmin Han  ⁵, Zhihui Xu  ⁶, Xudong Li  ⁷, Chaoliang Shi  ³, Jing Zhang  ⁸, Deyi Luo  ⁹, Guowei Shi  ¹⁰, Yaoguang Zhang  ¹¹ （Affiliations ¹ Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, NO.1 DaHua Road, Dong Dan, Beijing, 100730, China. ² Department of Urology, West China Hospital, Sichuan University, No.37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, China. ³ Department of Urology, Shanghai Fifth People's Hospital Affiliated to Fudan University, No.128 Ruili Road, Minhang District, Shanghai, China. ⁴ Department of Urology, Nanfang Hospital, Southern Medical University, No. 1838, Guangzhou Avenue North, Guangzhou, 510515, Guangdong, China. ⁵ Department of Urology, Shanghai General Hospital, No. 85/86, Wujin Road, Hongkou District, Shanghai, China. ⁶ Department of Urology, Zhejiang Provincial People's Hospital, No.158 Shangtang Road, Xiacheng District, Hangzhou, Zhejiang, China. ⁷ Department of Urology, The First Affiliated Hospital of Xi'an Jiao Tong University, 227 Yanta West Road, Yanta District, Xi'an, Shaanxi, China. ⁸ Department of Medical Affairs, Floor 4/5, Building 12, No.789 Puxing Road, Minhang District, MedTecXShanghai, China. ⁹ Department of Urology, West China Hospital, Sichuan University, No.37 Guoxue Alley, Wuhou District, Chengdu, Sichuan, China. luodeyi@scu.edu.cn. ¹⁰ Department of Urology, Shanghai Fifth People's Hospital Affiliated to Fudan University, No.128 Ruili Road, Minhang District, Shanghai, China. dr.sgw@189.cn. ¹¹ Department of Urology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, NO.1 DaHua Road, Dong Dan, Beijing, 100730, China. zhang003887@sina.com.）

出处： European journal of medical research 2025

关键词： Efficacy;Non-invasive low-frequency tibial nerve stimulator;Overactive bladder;Randomized clinical trial;Safety.

摘要： Objectives: To evaluate the efficacy and safety of a non-invasive low-frequency tibial nerve stimulator (TNS-01) vs sham control in relieving the symp ...

作者： Xin Liu  ¹, Ying Yuan  ², Yue Wu  ¹, Chengcheng Zhu  ², Yuying Liu  ¹, Bilian Ke  ¹ （Affiliations ¹ Department of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Investigative ophthalmology & visual science 2025

摘要： Purpose: Scleral extracellular matrix (ECM) remodeling and weakened scleral stiffness are characteristic of myopia. The purpose of this study was to i ...

作者： Weiliang Jiang¹²³;Bingjie Guan⁴;Hongcheng Sun⁴;Yushuai Mi⁵;Sanjun Cai¹⁶⁷;Rong Wan²³;Xinxiang Li⁶⁷;Peng Lian⁶⁷;Dawei Li⁶⁷CA1;null;Senlin Zhao⁶⁷CA2 （¹Cancer Institute, Fudan University Shanghai Cancer Center, No. 270 Dong’an Road, Shanghai, China;²Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, China;³Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, No. 650 New Songjiang Road, Shanghai, China;⁴Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 New Songjiang Road, Shanghai, China;⁵Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, No. 247 Beiyuan Road, Jinan, Shandong, China;⁶Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, No. 270 Dong’an Road, Shanghai, China;⁷Department of Oncology, Shanghai Medical College, Fudan University, No. 270 Dong’an Road, Shanghai, China）

出处： Nature Communications 2025

摘要： Liver metastasis (LM) poses a significant challenge in cancer treatment, with limited available therapeutic options and poor prognosis. Understanding ...

作者： Xiaoying Luo¹;Songjiao Zhao²;Tao Wang²;Xin He¹;Mingxuan Yang³;Jie Tao²;Shenmin Zhu¹CA1;Hui Zhao²CA2 （¹State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;²Department of Ophthalmology, National Clinical Research Center for Eye Diseases, Shanghai Key Clinical Specialty, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;³School of Life Sciences, Tsinghua University, Beijing 100084, China）

出处： ACS Nano 2025

关键词： cellulose nanocrystals;corneal repair;contact lenses;biomimetic;nanoarchitectonics

摘要： Consistent corneal epithelial injury would cause chronic inflammation, neovascularization, and even corneal scarring, resulting in vision loss. Rapid ...

作者： Shu Li^1,2;Jiani Pan³;Yan Xu³;Zhengyue Dai¹ & …Qiong Fang¹ （¹Shanghai Jiao Tong University School of Nursing, Shanghai, China;²Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;³Department of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： BMC Health Services Research 2025

关键词： Diabetic Macular Edema;Intravitreal anti-VEGF treatment;Timely injection

摘要： Purpose To explore the factors influencing the untimely receipt of intravitreal anti-vascular endothelial growth factor (VEGF) injections in patients ...

作者： Kai Zhu^{1 na1};Wanxin Liu^{1 na1};Yuanyuan Peng^{1 na1};Xiaoqiang Wang¹;Zhenhao Wang¹;Jun Zheng¹;Guoying Deng² & …Qiugen Wang^1,2 （¹Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, P.R. China;²Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, P.R. China）

出处： Journal of Orthopaedic Surgery and Research 2025

关键词： Shuanghe decoction;Steroid-induced osteonecrosis of the femoral head;Network pharmacology;Metabolomics;Gut microbiota

摘要： Background Steroid-induced osteonecrosis of the femoral head (SONFH) is a challenging and debilitating orthopedic condition with a rising incidence i ...