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作者: Mengyu Tao  1, Wenting Liu  2   3, Jianhua Chen  2   3, Rujiao Liu  2   3, Jianling Zou  2   3, Bo Yu  2   3, Chenchen Wang  2   3, Mingzhu Huang  2   3, Qingjian Chen  1, Zhe Zhang  2   3, Zhiyu Chen  2   3, Haoyu Sun  2   3   4, Cheng Zhou  5, Shuguang Tan  6, Yuxuan Zheng  7, Hongxia Wang  2   3 (Affiliations 1 Department of Oncology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200800, P. R. China. 2 Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, P. R. China. 3 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China. 4 Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. 5 Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, P. R. China. 6 The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China. 7 Human Phenome Institute, Minhang Hosptial, Fudan University, Shanghai, 201203, P. R. China.)

出处: Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词: AP‐1 family;CAF;CDCP1;PDAC;heterogeneity.

摘要: Cancer-associated fibroblasts (CAFs) play a crucial role in the progression of pancreatic ductal adenocarcinoma (PDAC). Here, integrated single-cell R ...

作者: Haihong Zhu  1   2, Liping Ouyang  2   3, Yangguang Huang  2, Ji Tan  4, Chunyu Liu  5, Qian Wang  2, Rongkun Huang  2, Wing Tak Wong  6, Xuanyong Liu  4   7, Haobo Pan  5, Yun Liao  1   2 (Affiliations 1 Department of Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 2 Department of Pharmacy, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. 3 Hongqiao International Institute of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. 4 State Key Laboratory of Advanced Ceramics, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China. 5 Shenzhen Key Laboratory of Marine Biomedical Materials, CAS-HK Joint Lab of Biomaterials, The Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. 6 School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, 999077, China. 7 School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Sub-Lane Xiangshan, Hangzhou, 310024, China.)

出处: Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025

关键词: TRPV2;borate glass;calcium overload;precise breast cancer treatment;ultrasound.

摘要: Effective and precise treatment of breast cancer, particularly with bone metastasis, remains a significant challenge. Here, a dual-gating strategy com ...

作者: Junjun Xiong #  1, Xuhui Ge #  1   2   3, Dishui Pan #  1, Yufeng Zhu  1, Yitong Zhou  1, Yu Gao  1, Haofan Wang  1, Xiaokun Wang  1, Yao Gu  1, Wu Ye  1, Honglin Teng  4, Xuhui Zhou  5   6   7, Zheng Wang  8, Wei Liu  9   10   11, Weihua Cai  12 (Affiliations 1 Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. 2 Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, China. 3 Department of Stress Medicine, Faculty of Psychology, Naval Medical University, Shanghai, China. 4 Department of Orthopedics (Spine Surgery), The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. 5 Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, China. zhouxuhui@smmu.edu.cn. 6 Department of Stress Medicine, Faculty of Psychology, Naval Medical University, Shanghai, China. zhouxuhui@smmu.edu.cn. 7 Translational Research Centre of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhouxuhui@smmu.edu.cn. 8 Department of Orthopedics, Chinese PLA General Hospital, Beijing, China. wangzheng301@163.com. 9 Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. liuweiorth@njmu.edu.cn. 10 Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai, China. liuweiorth@njmu.edu.cn. 11 Department of Stress Medicine, Faculty of Psychology, Naval Medical University, Shanghai, China. liuweiorth@njmu.edu.cn. 12 Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. caiwhspine@njmu.edu.cn.)

出处: Cell death and differentiation 2025

摘要: Astrocytic metabolic reprogramming is an adaptation of metabolic patterns to meet increased energy demands, although the role after spinal cord injury ...

作者: Xie, Yuna;Wang, RuilanaCAaaDepartment of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, China)

出处: American Journal of Respiratory and Critical Care Medicine 2025

作者: Xie, Yihuia;Shi, Weiminb;Yin, WenhaoaCAa;Mei, XingyubCAbaDepartment of Dermatology, The Affiliated Hospital of Jiaxing University, The First Hospital of Jiaxing, Zhejiang, Jiaxing, China;bDepartment of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Journal of Cosmetic Dermatology 2025

关键词: 2940 erbium laser;308 nm excimer light;vitiligo

摘要: Background: A 308 nm excimer light is an effective treatment for vitiligo, with fewer treatment times, rapid obvious effects, relatively complete pigm ...

作者: Ximo Xu #  1   2, Shaopeng Zhang #  1, Zai Luo  1, Yan Zheng  2   3, Tingting Kong  2   3, Chen Huang  4, Zhengjun Qiu  5 (Affiliations 1 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Pancreatic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. richard-hc@sohu.com. 5 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhengjun.qiu@shgh.cn.)

出处: Annals of surgical oncology 2025

关键词: Gastrointestinal tumors;Post-transplant malignancy;Transplantation;Treatment;Tumor microenvironment.

摘要: The increasing success of organ transplantation has significantly improved survival for patients with end-stage diseases, yet it introduces a complex ...

作者: Yang, Fana,b,c;Gao, Yanga,b,c;Han, Binga,b,c;Zhu, Wena,b,c;Wang, Guanxionga,b,c;Liu, Litinga,b,c;Shen, Qunshana,d,e;Song, Binga,b,c;Lv, Mingronga,b,f;Wu, Huana,b,c;Tang, Dongdonga,b,c;Zhou, Pinga,b,c;Wei, Zhaoliana,b,c;Xu, Yupinga,b,cCAa;Cao, Yunxiaa,b,c,fCAb;He, Xiaojina,b,gCAcaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China;bNHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, China;cEngineering Research Center of Biopreservation and Artificial Organs, Hefei, China;dAnhui Provincial Institute of Translational Medicine, Hefei, China;eAnhui Provincial Human Sperm Bank, The First Affiliated Hospital of Anhui Medical University, Hefei, China;fKey Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, China;gReproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Andrology 2025

关键词: aberrant acetylation;asthenoteratozoospermia;CDYL;male infertility;splicing mutation

摘要: Objectives: Acetylated tubulin is a hallmark of flagellar stability in spermatozoa, and studies have demonstrated the ability of CDYL to function as a ...

作者: Yiyang Shu  1, Chaoyang Zhang  2, Yanlong Bi  3, Jingfa Zhang  2 (Affiliations 1 Department of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China. Electronic address: 13917311571@139.com. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; The Primasia International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen), Shenzhen 518000, PR China. C-MER (Shenzhen) Dennis Lam Eye Hospital, Shenzhen 518000, PR China. C-MER Dennis Lam & Partners Eye Center, C-MER International Eye Care Group, Hong Kong 999077, China. 3 Department of Ophthalmology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China; Tongji Eye Institute, School of Medicine, Tongji University, Shanghai 200065, China. Electronic address: biyanlong@tongji.edu.cn.)

出处: Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2025

关键词: diabetic macular edema;hyperreflective foci;optical coherence tomography angiography;outer blood-retinal barrier;subretinal fluid.

摘要: Purpose: To evaluate the correlation between hyperreflective foci (HRF), the biomarker of activated microglia, and subretinal fluid (SRF), representin ...

作者: Fubo Wang #  1   2   3   4   5, Chengbang Wang #  6   7   8, Shaohua Chen #  9   10, Chunmeng Wei #  6   7, Jin Ji #  11   12, Yan Liu #  13   14, Leifeng Liang  15, Yifeng Chen  16, Xing Li  17, Lin Zhao  11, Xiaolei Shi  11, Yu Fang  11, Weimin Lu #  18, Tianman Li  19, Zhe Liu  20, Wenhao Lu  6   21, Tingting Li  13   14, Xiangui Hu  22, Mugan Li  23, Fuchen Liu  24, Xing He  25, Jiannan Wen  26, Zuheng Wang  7, Wenxuan Zhou  24, Zehui Chen  27, Yonggang Hong  28, Shaohua Zhang  28, Xiao Li  29, Rongbin Zhou  6   21, Linjian Mo  7, Duobing Zhang  18   30, Tianyu Li  7, Qingyun Zhang  9, Li Wang #  31, Xuedong Wei #  32, Bo Yang #  11, Shenglin Huang #  33, Huiyong Zhang #  6, Guijian Pang #  16, Liu Ouyang  34   35, Zhenguang Wang  36, Jiwen Cheng  37, Bin Xu  8, Zengnan Mo  38   39 (Affiliations 1 Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, 530021, Guangxi, China. wangfubo@gxmu.edu.cn. 2 Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Guangxi, 530021, China. wangfubo@gxmu.edu.cn. 3 School of Life Sciences, Guangxi Medical University, Nanning , Guangxi, 530021, China. wangfubo@gxmu.edu.cn. 4 Department of Urology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China. wangfubo@gxmu.edu.cn. 5 School of Public Health, Guangxi Medical University, Nanning , Guangxi, 530021, China. wangfubo@gxmu.edu.cn. 6 Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, 530021, Guangxi, China. 7 Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Guangxi, 530021, China. 8 Department of Urology, Shanghai Ninth People'S Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China. 9 Department of Urology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China. 10 School of Public Health, Guangxi Medical University, Nanning , Guangxi, 530021, China. 11 Department of Urology, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China. 12 Department of Urology, Naval Medical Center, Naval Medical University, Shanghai, 200433, China. 13 Department of Breast, Bone and Soft Tissue Oncology, Guangxi Medical University Cancer Hospital, Nanning , Guangxi, 530021, China. 14 Laboratory of Breast Cancer Diagnosis and Treatment Research of Guangxi, Department of Education, Affiliated Tumor Hospital of Guangxi Medical University, Nanningaq , Guangxi, 530021, China. 15 Department of Oncology, The First People'S Hospital of Yulin, the, Sixth Affiliated Hospital of Guangxi Medical Universityaq, Guangxi, 537000, China. 16 Department of Urology, The First People'S Hospital of Yulin, the, Sixth Affiliated Hospital of Guangxi Medical Universityaq, Guangxi, 537000, China. 17 Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 18 Department of Urology, Suzhou Hospital of Anhui Medical University, Suzhouaq , AnHui, 234000, China. 19 Department of Hepatobiliary Surgery, The First People'S Hospital of Yulin, the, Sixth Affiliated Hospital of Guangxi Medical Universityaq, Guangxi, 537000, China. 20 Department of Urology, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, Jiangsu, China. 21 Collaborative Innovation Centre of Regenerative Medicine and Medical Bioresource Development and Application Co-Constructed by the Province and Ministry, Guangxi Medical University, Nanning , Guangxi, 530021, China. 22 Department of Hepatobiliary and Pancreatic Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. 23 Department of Colorectal and Anal Surgery, The First People'S Hospital of Yulin, the, Sixth Affiliated Hospital of Guangxi Medical Universityaq, Guangxi, 537000, China. 24 The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, 200438, China. 25 Outpatient Department, Qingdao, Special Servicemen Recuperation Center of PLA Navy , Shandong, 266071, China. 26 The First Outpatient Department, General Hospital of PLA Northern Theater Command, Shenyangaq , Liaoning, 110001, China. 27 Department of Laboratory Medicine, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, China. 28 Department of Colorectal Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. 29 School of Life Sciences, Guangxi Medical University, Nanning , Guangxi, 530021, China. 30 Suzhou Key Laboratory for Clinical Big Data and Intelligent Treatment of Urinary System Diseases, Suzhouaq , AnHui, 234000, China. 31 Research Center for Intelligence Information Technology, Nantong University, Nantong , Jiangsu, 226001, China. 32 Department of Urology, The First Afliated Hospital of Soochow University, Suzhou, 215006, China. 33 Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 201321, China. 34 Department of Hepatobiliary and Pancreatic Surgery, Changhai Hospital, Naval Medical University, Shanghai, 200433, China. aqqwbjsqtb@163.com. 35 Department of Hepatobiliary and Pancreatic Surgery, School of Medicine, Shanghai Fourth People's Hospital, Tongji University, Shanghai, 200434, China. aqqwbjsqtb@163.com. 36 The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, 200438, China. wangzhenguang82@163.com. 37 Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Guangxi, 530021, China. chengjiwen@stu.gxmu.edu.cn. 38 Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, 530021, Guangxi, China. mozengnan@gxmu.edu.cn. 39 Department of Urology, The First Affiliated Hospital of Guangxi Medical University, Guangxi Medical University, Guangxi, 530021, China. mozengnan@gxmu.edu.cn.)

出处: Molecular cancer 2025

关键词: Biomarker;Cancer detection;Cancer localization;Exosomal tumor RNA signatures;Exosome;Multi-cancer.

摘要: Background: Cancer remains a leading global cause of mortality, making early detection crucial for improving survival outcomes. The study aims to deve ...

作者: Zhuoting Zhu  1, Yueye Wang  2, Ziyi Qi  3, Wenyi Hu  4, Xiayin Zhang  5, Siegfried K Wagner  6, Yujie Wang  4, An Ran Ran  7, Joshua Ong  8, Ethan Waisberg  9, Mouayad Masalkhi  10, Alex Suh  11, Yih Chung Tham  12, Carol Y Cheung  7, Xiaohong Yang  5, Honghua Yu  5, Zongyuan Ge  13, Wei Wang  14, Bin Sheng  15, Yun Liu  16, Andrew G Lee  17, Alastair K Denniston  18, Peter van Wijngaarden  19, Pearse A Keane  6, Ching-Yu Cheng  12, Mingguang He  20, Tien Yin Wong  21 (Affiliations 1 Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, Australia; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, VIC, Australia. Electronic address: wongtienyin@tsinghua.edu.cn. 2 School of Optometry, the Hong Kong Polytechnic University, Hong Kong, China. 3 Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, Australia; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, VIC, Australia; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai, China. 4 Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, Australia; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, VIC, Australia. 5 Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. 6 NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK; Institute of Ophthalmology, University College London, London, UK. 7 Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. 8 Department of Ophthalmology and Visual Sciences, University of Michigan Kellogg Eye Center, Ann Arbor, USA. 9 Department of Clinical Neurosciences, University of Cambridge, Cambridge,UK. 10 University College Dublin School of Medicine, Belfield, Dublin, Ireland. 11 Tulane University School of Medicine, New Orleans, LA, USA. 12 Department of Ophthalmology and Centre for Innovation and Precision Eye Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore. 13 Monash e-Research Center, Faculty of Engineering, Airdoc Research, Nvidia AI Technology Research Center, Monash University, Melbourne, VIC, Australia. 14 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. 15 Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, China. 16 Google Research, Mountain View, CA, USA. 17 Center for Space Medicine and The Department of Ophthalmology (Adjunct Professor), Baylor College of Medicine, Houston, USA; Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, USA; The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, USA; Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, USA; Department of Ophthalmology, University of Texas Medical Branch, Galveston, USA; University of Texas MD Anderson Cancer Center, Houston, USA; Texas A&M College of Medicine, Bryan, USA; Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, USA. 18 NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK; Institute of Ophthalmology, University College London, London, UK; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre (BRC), University Hospital Birmingham and University of Birmingham, Birmingham, UK; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK; Birmingham Health Partners Centre for Regulatory Science and Innovation, University of Birmingham, Birmingham, UK. 19 Centre for Eye Research Australia, Ophthalmology, University of Melbourne, Melbourne, VIC, Australia; Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, VIC, Australia; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia. 20 School of Optometry, the Hong Kong Polytechnic University, Hong Kong, China; Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong, China; Centre for Eye and Vision Research (CEVR), 17W Hong Kong Science Park, Hong Kong, China. 21 School of Clinical Medicine, Beijing Tsinghua Changgung Hospital, Tsinghua Medicine, Tsinghua University, Beijing, China; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore. Electronic address: Lisa.zhu@unimelb.edu.au.)

出处: Progress in retinal and eye research 2025

关键词: Artificial intelligence;Big data;Disease detection;Disease prediction;Oculomics;Retinal imaging;Systemic diseases.

摘要: The eye provides novel insights into general health, as well as pathogenesis and development of systemic diseases. In the past decade, growing evidenc ...

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