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作者: Yuwei Wang;Yuhong Chen;Jian Liang;Mei Jiang;Ting Zhang;Xiaoling Wan;Jiahui Wu;Xiaomeng Li;Jieqiong Chen;Junran Sun;Yifan Hu;Peirong Huang;Jingyang Feng;Te Liu;Xiaodong Sun (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 2 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China. 3 Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, China. 4 National Clinical Research Center for Eye Diseases, Shanghai 200080, China. 5 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China.)

出处: Journal of molecular cell biology 2023

关键词: HMGA2;METTL3;N6-methyladenosine;epithelial–mesenchymal transition;subretinal fibrosis.

摘要: Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration (nAMD). Myofibroblast ...

作者: Changjiang Gu #  1, Fanqi Kong #  1, Junkai Zeng #  1, Xiangwu Geng  1, Yanqing Sun  2, Xiongsheng Chen  3   4 (Affiliations 1 Spine Center, Department of Orthopaedics, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200003, People's Republic of China. 2 Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, 200080, Shanghai, PR China. syq04281226@126.com. 3 Spine Center, Department of Orthopaedics, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200003, People's Republic of China. chenxiongsheng@vip.sohu.com. 4 Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, 200080, Shanghai, PR China. chenxiongsheng@vip.sohu.com.)

出处: Cell & bioscience 2023

关键词: Ischemia reperfusion injury;Oxidative stress;RIPC;SIRT3.

摘要: Background: To study the protective effects of delayed remote ischemic preconditioning (RIPC) against spinal cord ischemia-reperfusion injury (SCIRI) ...

作者: J G Hong (Affiliation 1 Department of Pediatrics, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.)

出处: Zhonghua er ke za zhi = Chinese journal of pediatrics 2023

摘要: 喘息是6岁以下儿童常见的呼吸道症状,导致儿童喘息原因多样,年龄越小喘息的病因越复杂,要重视儿童喘息的病因分析,以免延误诊断。早期采用抗炎为主的干预措施有益于气道炎症相关性喘息症状的改善,但需及时评估干预效应,避免过度用药。.

作者: Di Cui;Jianneng Li;Ziqi Zhu;Michael Berk;Aimalie Hardaway;Jeffrey McManus;Yoon-Mi Chung;Mohammad Alyamani;Shelley Valle;Ritika Tiwari;Bangmin Han;Maryam Goudarzi;Belinda Willard;Nima Sharifi (Affiliations 1 Genitourinary Malignancies Research Center, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA. 2 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Metabolomics Shared Laboratory Resource, Lerner Research Institute. 4 Department of Urology, Glickman Urological and Kidney Institute, and. 5 Department of Hematology and Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.)

出处: The Journal of clinical investigation 2023

关键词: Oncology;Prostate cancer;Sex hormones.

摘要: After androgen deprivation, prostate cancer frequently becomes castration resistant (CRPC), with intratumoral androgen production from extragonadal pr ...

作者: Zhenyang Shen;Weiming Dai;Yuecheng Guo;Junjun Wang;Bo Shen;Binghang Li;Lungen Lu;Xiaobo Cai (Affiliations 1 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023

关键词: Yes-associated protein;ductular reaction;liver fibrosis;liver progenitor cells;transplantation.

摘要: Liver fibrosis is closely related to the proliferation and differentiation of liver progenitor cells (LPCs). Yes-associated protein (YAP) is a key eff ...

作者: Jifu Ge;Weikang Pan;Noel J Feeney;Leah Ott;Emily Anderson;Alessandro Alessandrini;Ivan Zanoni;James F Markmann;Alex G Cuenca (Affiliations 1 Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China. 2 Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA. 3 Massachusetts General Hospital, Division of Transplant Surgery, Department of Medicine, Boston, MA 02114, USA. 4 Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, MA 02114, USA; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. USA. 5 Department of Medicine, Division of Gastroenterology/Immunology, Boston Children's Hospital, Boston, MA 02115, USA. 6 Massachusetts General Hospital, Division of Transplant Surgery, Department of Medicine, Boston, MA 02114, USA; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, MA 02114, USA. 7 Department of Surgery, Boston Children's Hospital, Boston, MA 02115, USA; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, MA 02114, USA. Electronic address: alex.cuenca@childrens.harvard.edu.)

出处: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2023

摘要: Advances in immunosuppression have been relatively stagnant over the last 2 decades and transplant recipients continue to experience long term morbidi ...

作者: Y X Qian;S Y Liu;X J Wang;S J Xia (Affiliation 1 Department of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Institute of Urology, Shanghai Jiao Tong University, Shanghai 200080, China.)

出处: Zhonghua yi xue za zhi 2023

摘要: Benign prostatic hyperplasia (BPH) is one of the most common diseases in elderly men. Transurethral resection of prostate (TURP), as an important BPH ...

作者: Hui-Yi Li;Seng-Wang Fu;Jun-Cheng Wu;Zheng-Hong Li;Ming-Yi Xu (Affiliations 1 Department of Gastroenterology, School of Medicine, Shanghai East Hospital, Tongji University, No. 1800, Yuntai Rd, Shanghai, 310115, China. 2 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 3 Department of Gastroenterology, The Third Affiliated Hospital of Soochow University, Changzhou, 213000, Jiangsu Province, China. 4 Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 1665, Kongjiang Rd, Shanghai, 200092, China. lee0072312@163.com. 5 Department of Gastroenterology, School of Medicine, Shanghai East Hospital, Tongji University, No. 1800, Yuntai Rd, Shanghai, 310115, China. angela752022@163.com.)

出处: Inflammation research : official journal of the European Histamine Research Society ... 2023

关键词: KCs, Kupffer cells;Macrophages;NASH, Non-alcoholic steatohepatitis;Vsig4, V-set and immunoglobulin domain-containing 4;scRNA-seq, Single-cell RNA sequencing.

摘要: Background: The role of macrophages in the pathogenesis of nonalcoholic steatohepatitis (NASH) is complex and unclear. Methods: Single-cell RNA sequen ...

作者: Z Y Qi  1, J Chen  1, X G He  1 (Affiliation 1 Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Division of Ophthalmology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 201103, China.)

出处: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2023

摘要: Myopia, especially high myopia, seriously affects the children and adolescents' quality of learning and life relating to a series of eye diseases. Mor ...

作者: Luca Giovanni Locatello #  1   2   3, Serena Jiang #  1, Lixiao Chen  3, Saverio Caini  4, Giandomenico Maggiore  1, Pin Dong  3, Oreste Gallo  5   6 (Affiliations 1 Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy. 2 Department of Otorhinolaryngology, University Hospital "Santa Maria Della Misericordia", Azienda Sanitaria Universitaria Friuli Centrale (ASUFC), Udine, Italy. 3 Department of Otolaryngology-Head & Neck Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China. 4 Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. 5 Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy. oreste.gallo@unifi.it. 6 Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy. oreste.gallo@unifi.it.)

出处: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2023

关键词: Adjuvant radiotherapy;Functional outcomes;Laryngeal cancer;Laryngeal surgery;OPLS;PORT;Partial laryngectomy.

摘要: Background: The oncological and functional role of postoperative radiotherapy (PORT) after open partial laryngeal surgery (OPLS) remains debatable. Me ...

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