作者： Xichen Wan;Songjiao Zhao;Yiqin Dai;Jing Zhang;Yan Shen;Lan Gong;Qihua Le （Affiliations ¹ Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Fudan, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Research Centre, Eye, Ear, Nose and Throat Hospital of Fudan University, Fudan, China. ⁴ Myopia Key Laboratory of Ministry of Health, Eye, Ear, Nose and Throat Hospital of Fudan University, Fudan, China.）

出处： Cell proliferation 2023

摘要： Our previous finding revealed that WNT16b promoted the proliferation of human limbal epithelial stem cells (hLESCs) through a β-catenin independent pa ...

作者： Xiangui He;Jingjing Wang;Zhuoting Zhu;Kaidi Xiang;Xinzi Zhang;Bo Zhang;Jun Chen;Jinliuxing Yang;Linlin Du;Chunjin Niu;Mei Leng;Jiannan Huang;Kun Liu;Haidong Zou;Mingguang He;Xun Xu （Affiliations ¹ Department of Clinical Research, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center and Shanghai Children Myopia Institute, Shanghai, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Center of Eye Shanghai Key Laboratory of Ocular Fundus Diseases, Engineering Center for Visual Science and Photomedicine, Shanghai, China. ³ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. ⁴ Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia. ⁵ Division of Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia. ⁶ Department of Ophthalmology Prevention, Changning Center for Disease Control and Prevention, Shanghai, China. ⁷ Department of Teaching and Research, Changning Institute of Education, Shanghai, China.）

出处： JAMA network open 2023

摘要： Importance: Myopia is a global concern, but effective prevention measures remain limited. Premyopia is a refractive state in which children are at hig ...

作者： Wen Su;Zhanhua Liang;Wei Mao;Ming Shao;Xingyue Hu;Yuncheng Wu;Wenshi Wei;Zhenguo Liu;Kezhong Zhang;Beisha Tang;Shuai Cao;Zhuolun Song;Haibo Chen （Affiliations ¹ Department of Neurology, Beijing Hospital, Beijing, 100730, China. ² National Center of Gerontology, Beijing, 100730, China. ³ Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China. ⁴ Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China. ⁵ Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100032, China. ⁶ Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, 510000, China. ⁷ Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 133000, China. ⁸ Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁹ Department of Neurology, Huadong Hospital Affiliated to Fudan University, Shanghai, 20040, China. ¹⁰ Department of Neurology, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200092, China. ¹¹ Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. ¹² Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China. ¹³ Department of China Drug Development, Lundbeck (Beijing) Pharmaceutical Consulting Co, Ltd., Beijing, 100020, China. ¹⁴ Department of Neurology, Beijing Hospital, Beijing, 100730, China. dr_chenhaibo@126.com. ¹⁵ National Center of Gerontology, Beijing, 100730, China. dr_chenhaibo@126.com. ¹⁶ Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China. dr_chenhaibo@126.com.）

出处： Drug safety 2023

摘要： Introduction: Rasagiline is indicated for treating idiopathic Parkinson's disease (PD) as monotherapy and adjunct therapy to levodopa in patients. Obj ...

作者： Xu Dai;Ziting Lan;Runjianya Ling;Yarong Yu;Lihua Yu;Zhigang Lu;Chengxing Shen;Kakuya Kitagawa;Yuehua Li;Wenyi Yang;Jiayin Zhang （Affiliations ¹ Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai, China. ² Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, 200080, China. ³ Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, #600, Yishan Rd, Shanghai, China. ⁴ Department of Advanced Diagnostic Imaging, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan. ⁵ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, 200080, China. wenyi.yang@shgh.cn. ⁶ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, 200080, China. andrewssmu@msn.com.）

出处： European radiology 2023

关键词： Computed tomography angiography;Cost-benefit analysis;Myocardial ischemia;Myocardial perfusion imaging;Prognosis.

摘要： Objectives: To compare the financial and clinical outcomes of CT myocardial perfusion imaging (CT-MPI) + coronary CT angiography (CCTA)-guided versus ...

作者： Jiecheng Qian;Yankun Guo;Youfa Xu;Xinyu Wang;Jianming Chen;Xin Wu （Affiliations ¹ Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China. ² Department of Pharmacy, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. ³ Department of Pharmacy, Organization Department, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Shanghai Wei Er Lab, Shanghai, China. ⁵ Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China. chenjm0711@163.com. ⁶ Shanghai Wei Er Lab, Shanghai, China. chenjm0711@163.com. ⁷ Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, China. wuxin007@126.com. ⁸ Shanghai Wei Er Lab, Shanghai, China. wuxin007@126.com. ⁹ Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai, China. wuxin007@126.com.）

出处： Drug delivery and translational research 2023

关键词： Composite carrier;Drug delivery;Liposome;Micelle;Nanoformulation.

摘要： Among various nanocarriers, liposomes, and micelles are relatively mature drug delivery systems with the advantages of prolonging drug half-life, redu ...

作者： Bin Han ^{#  1}, Xiaoqian Zhang ^{#  1}, Ling Wang  ¹, Weijie Yuan  ¹ （Affiliation ¹ Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.）

出处： Microbiology spectrum 2023

关键词： IFNγ+ CD4+ T cell;cardiomyopathy;chronic kidney disease;gut microbiota;uremic cardiomyopathy.

摘要： Uremic cardiomyopathy (UCM) correlates with chronic kidney disease (CKD)-induced morbidity and mortality. Gut microbiota has been involved in the path ...

作者： Hong Hu  ¹, Xiaoyuan Gong  ¹, Kai Xu  ¹, Shenzheng Luo  ¹, Wei Gao  ², Baiwen Li  ¹, Dadao Jing  ¹ （Affiliations ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Frontiers in medicine 2023

关键词： colonoscopy;colorectal adenomas;colorectal cancer;risk factors;screening.

摘要： Background: Several studies have shown that colorectal adenomas are the most important precancerous lesions. The colonoscopic identification of groups ...

作者： Nan Zhu  ¹, Haochen Guan  ^{1   2}, Xuan Wang  ¹, Yueyue Zhang  ¹, Lijie Gu  ¹, Jieshuang Jia  ¹, Ling Wang  ¹, Weijie Yuan  ¹ （Affiliations ¹ Department of Nephrology, Shanghai General Hospital, Shanghai, China. ² Department of Nephrology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, China.）

出处： International journal of medical sciences 2023

关键词： EZH2;IL-6/sIL-6R;SP4;VEGF;angiogenesis;peritoneal dialysis.

摘要： Background: Interleukin-6 (IL-6)/soluble IL-6 receptor (sIL-6R) promotes peritoneal angiogenesis by stimulating SP4-mediated vascular endothelial grow ...

作者： Mengqi Jia¹;Zhenghua Wu^1,21;Wenqing Shi³;Shuowen Wang¹;Xucong Huang¹;Min Zhang⁴;Wuping Bao⁴;Aihua Bao⁴;Pengyu Zhang⁴;Fengming Ding⁴;Guogang Xie⁴;Yuefen Lou³CA2;Guorong Fan^1,2CA3 （¹Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, PR China;²School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China;³Department of Pharmacy, Shanghai Fourth People’s Hospital Affiliated to Tongji University School of Medicine, Shanghai 200434, PR China;⁴Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China）

出处： Journal of Pharmaceutical and Biomedical Analysis 2023

关键词： Dried plasma spots;Online solid phase extraction;LC-MS;Tyrosine kinase inhibitors;Therapeutic drug monitoring

摘要： Gefitinib, osimertinib and icotinib are the most commonly used tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer (NSCLC) with EGFR mutat ...

作者： Zhichao Zhang^1,2;Meng Hao^3,2;Xiangchun Zhang^4,2;Yufeng He³;Xiongsheng Chen¹CA1;Ethan Will Taylor⁵CA2;Jinsong Zhang³CA3 （¹Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China;²contributed equally.;³State Key Laboratory of Tea Plant Biology and Utilization, School of Tea & Food Science, Anhui Agricultural University, Hefei, 230036, China;⁴Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou, 310008, China;⁵Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC, 27402, USA）

出处： Trends in Food Science & Technology 2023

关键词： EGCG;COVID-19;SARS-CoV-2;Omicron variant;Tropism;The upper respiratory tract

摘要： Background COVID-19 due to SARS-CoV-2 infection has had an enormous adverse impact on global public health. As the COVID-19 pandemic evolves, the WHO ...