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作者: Liu, Kaiyuana;Zan, Pengfeia;Li, Zihuab;Lu, Henglib;Liu, Pengc;Zhang, Lib;Wang, Hongshenga;Ma, Xiaojuna;Chen, FengdCAa;Zhao, JingcCAb;Sun, WeiaCAcaDepartment of Bone Tumor Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;bSchool of Medicine, Tongji University, Shanghai, 200072, China;cScientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, No. 628 Zhenyuan Road, Guangdong, Shenzhen, 518107, China;dShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Stomatological Hospital and School of Stomatology, Fudan University, Shanghai, 200001, China)

出处: Advanced Healthcare Materials 2024

关键词: cGAS-STING;immunotherapy;mild-temperature PTT;osteosarcoma;pyroptosis

摘要: The immunosuppressive tumor microenvironment (ITME) of osteosarcoma (OS) poses a significant obstacle to the efficacy of existing immunotherapies. Des ...

作者: Dong, Lingkaia;Liu, Minchaoa;Fang, Mengb;Lu, Qianqiana;Li, Xingjina;Ma, Yanminga;Zhao, TiancongaCAaaSchool of Chemistry and Materials, Department of Chemistry, Laboratory of Advanced Materials and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers, Collaborative Innovation Center of Chemistry for Energy Materials (2011-iChEM), Fudan University, Shanghai, 200433, China;bDepartment of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China)

出处: Small 2024

关键词: artificial antigen presenting cell;emulsion;polydopamine;polymerization;vesicle

摘要: Albeit microemulsion systems have emerged as efficient platforms for fabricating tunable nano/microstructures, lack of understanding on the emulsion-i ...

作者: Song, Jiahuia;Dong, Jizeb;Yuan, Zhengchaoa;Huang, Moranb;Yu, Xiaoa;Zhao, Yuea;Shen, Yihonga;Wu, Jingleia;EL-Newehy, Mohamedc;Abdulhameed, Meera Moydeenc;Sun, BinbinaCAa;Chen, JiwubCAb;Mo, XiumeiaCAcaState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China;bDepartment of Sports Medicine, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, 200080, China;cDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia)

出处: Advanced Healthcare Materials 2024

关键词: conductive  NGCs;electrospun nanofibers;peripheral nerve regeneration;shape memory

摘要: To solve the problems of slow regeneration and mismatch of axon regeneration after peripheral nerve injury, nerve guidance conduits (NGCs) have been w ...

作者: Gu, Junhaoa;Cheng, Danlinga;Li, Haiyanb;Yu, Taoa;Zhang, Zhenghea;Liu, Yuea;Wang, XiaoyingcCAa;Lu, XiabCAb;Li, JingchaoaCAcaState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China;bDepartment of Nuclear Medicine, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, 225001, China;cOffice of Hospital Infection and Disease Control and Prevention, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China)

出处: Journal of Materials Chemistry B 2024

摘要: Due to the rapid progression and aggressive metastasis of breast cancer, its diagnosis and treatment remain a great challenge. The simultaneous inhibi ...

作者: Ou, Ningjinga,b,c;Wang, Yucic;Xu, Shuaia;Luo, Jiaqianga;Zhang, Chenwanga;Zhang, Yangyic;Shi, Xiaoyanc;Xiong, Minggangc;Zhao, Liangyub;Ji, Zhiyonga;Zhang, Yuxianga;Zhao, Jingpenga;Bai, Haoweia;Tian, Ruhuia;Li, Penga;Zhi, Erleia;Huang, Yuhuaa;Chen, Weia;Wang, Ruiqic;Jin, Yuxuanc;Wang, Dianc;Li, ZhengaCAa;Chen, HaocCAb;Yao, ChenchengaCAcaDepartment of Andrology, Center for Men's Health, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China;bDepartment of Urology, Department of Interventional Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangdong, Zhuhai, 519000, China;cDepartment of Human Cell Biology and Genetics, Joint Laboratory of Guangdong & Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Guangdong, Shenzhen, 518000, China)

出处: Advanced Science 2024

关键词: DAZ;microdeletion of AZFc;proliferation;RNA binding protein;spermatogenic failure

摘要: Primate-specific DAZ (deleted in azoospermia) has evolved in the azoospermia factor c (AZFc) locus on the Y chromosome. Loss of DAZ is associated with ...

作者: Jian, Chuanjianga;Wang, Minjiaa;Qian, Yunyunb;Song, Xuejiaoa;Wang, Lic;Li, Linga;Huang, Lulud;Wang, Guane;Shi, Xianjiea;Dong, JinqiaofCAa;Li, HaobCAb;Lin, AngdCAc;Shi, LeileicCAdaThe Eighth Affiliated Hospital Sun Yat-sen University, 3025 Shennan Middle Road, Shenzhen, 518000, China;bDepartment of Organ Transplantation, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Fujian, Xiamen, 361005, China;cPrecision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China;dVaccine Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China;eDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Liaoning, Dalian, 116044, China;fSchool of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, 200240, China)

出处: Advanced Healthcare Materials 2024

关键词: active peptide hydrogel;anti-inflammatory;diabetic wound healing;macrophages polarization;TLR4

摘要: Persistent inflammation and disrupted immunoregulation are critical factors in impeding diabetic wound healing. While immunoregulatory hydrogel dressi ...

作者: Liu, Fabinga,b;Wang, Guangxuec;Zhao, Limingd;Chen, Guohana;Dong, Lina;Li, QinchuanaCAa;Zhu, DongyieCAbaDepartment of Cardiothoracic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China;bDepartment of Cardiothoracic Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200080, China;cResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China;dDepartment of Emergency, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China;eDepartment of Respiratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China)

出处: Advanced Biology 2024

关键词: AMP activated protein kinases;apoptosis;proliferation;squamous cell carcinoma;Toosendanin

摘要: Lung squamous cell carcinoma (LUSC) is the second most common type of non-small cell lung cancer. Toosendanin can target critical cancer cell survival ...

作者: Xiao-Ping Wang;Bo Wang (Affiliations 1 Jiading Branch of Shanghai General Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China. 2 Zhongshan Hospital, Fudan University, Shanghai, China.)

出处: Frontiers in pain research (Lausanne, Switzerland) 2023

关键词: VSL#3;abdominal and pelvic pain;acupuncture;endometriosis;irritable bowel syndrome;neuropathy.

摘要: This paper provides a description and evaluation of the main features of John Wilson's approach to moral education. In the first section we analyse th ...

作者: Yuhang Ma;Ying Zhang;Yi Lin;Xiaoying Ding;Yuntao Zhang (Affiliations 1 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 2 School of Digital Construction, Shanghai Urban Construction Vocational College, Shanghai, 201999, China.)

出处: Open medicine (Warsaw, Poland) 2023

关键词: biomechanical property;bone mineral density;histomorphometry;osteogenic growth peptide C-terminal pentapeptide;osteoporosis.

摘要: This study aimed to explore the effects of osteogenic growth peptide C-terminal pentapeptide (G36G), and its analog G48A on bone modeling in rats with ...

作者: Jiawei Lu;Pusheng Yang;Lanting Yu;Ni Xie;Ying Wu;Baiwen Li (Affiliations 1 Department of Gastroenterology, Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. 2 Department of Obstetrics and Gynecology, Shanghai Key Laboratory of Gynecology Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.)

出处: Diagnostics (Basel, Switzerland) 2023

关键词: immune infiltration;lncRNA;m7G;overall survival;pancreatic adenocarcinoma;prognostic signature.

摘要: N7-Methylguanosine (m7G) modification holds significant importance in regulating posttranscriptional gene expression in epigenetics. Long non-coding R ...

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