作者： Haoran Mu  ¹, Qi Zhang  ², Dongqing Zuo  ¹, Jinzeng Wang  ³, Yining Tao  ¹, Zhen Li  ⁴, Xin He  ¹, Huanliang Meng  ¹, Hongsheng Wang  ¹, Jiakang Shen  ¹, Mengxiong Sun  ¹, Yafei Jiang  ¹, Weisong Zhao  ¹, Jing Han  ¹, Mengkai Yang  ¹, Zhuoying Wang  ¹, Yu Lv  ¹, Yuqin Yang  ⁵, Jing Xu  ¹, Tao Zhang  ¹, Liu Yang  ¹, Jun Lin  ⁶, Feng Tang  ⁷, Renhong Tang  ⁸, Haiyan Hu  ⁹, Zhengdong Cai  ¹, Wei Sun  ¹⁰, Yingqi Hua  ¹¹ （Affiliations ¹ Department of Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. ² Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ National Research Center for Translational Medicine at Shanghai, State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: jz.wang@sjtu.edu.cn. ⁴ State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, China; Simcere Zaiming Pharmaceutical Co., Ltd., Shanghai, China. ⁵ Department of Laboratory Animal Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, China; Jiangsu Simcere Pharmaceutical Co., Ltd., Nanjing, China. ⁸ State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, China; Jiangsu Simcere Pharmaceutical Co., Ltd., Nanjing, China; Simcere Zaiming Pharmaceutical Co., Ltd., Shanghai, China. ⁹ The Drug and Device Phase I Clinical Research Ward/Demonstration Research Ward of Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁰ Department of Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. Electronic address: viv-sun@sjtu.edu.cn. ¹¹ Department of Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. Electronic address: hua_yingqi@163.com.）

出处： Cell reports. Medicine 2025

关键词： IKZF1;MAT2A;MTAP deletion;PD-L1;immunotherapy;methionine metabolism;osteosarcoma;tumor microenvironment.

摘要： Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomic ...

作者： Yun Xie¹;Hui Lv¹;Daonan Chen¹;Peijie Huang¹;Zhigang Zhou¹;Ruilan Wang² （¹Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, Shanghai 201600, PR China;²Corresponding author at: Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Songjiang, Shanghai 201600, PR China.;Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, Shanghai 201600, PR China）

出处： International Journal of Cardiology: Heart & Vasculature 2025

关键词： Sepsis;Acute myocardial injury;CD36

摘要： Background: Sepsis-induced myocardial injury (SIMI) is a prevalent form of organ dysfunction with a significant impact on the mortality rate among sep ...

作者： Wenzhe Qian  ^{1   2}, Yue Wu  ^{1   2}, Xin Liu  ^{1   2}, Yuying Liu  ³, Min Li  ³, Ting Zhao  ³, Na Chen ^{#  4}, Bilian Ke ^{#  5   6} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China. ² National Clinical Research Center for Eye Diseases, Shanghai, China. ³ Department of Ophthalmology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai, 200127, China. ⁴ Department of Ophthalmology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai, 200127, China. chenna9972@163.com. ⁵ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China. kebilian@126.com. ⁶ Department of Ophthalmology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai, 200127, China. kebilian@126.com.）

出处： Journal of ophthalmic inflammation and infection 2025

关键词： Conjunctival epithelium;Cyclosporine A;Goblet cell;Interferon-γ;Mucin 5AC;Refractive surgery;Tear film;Tumor Necrosis Factor-α.

摘要： Background: Corneal refractive surgeries offer rapid vision correction, while dry eye disease remains a common postoperative complication that signifi ...

作者： D X Chen  ¹, Y J Wang  ¹, J Chen  ¹, J J Wang  ¹, B Zhang  ¹, H D Zou  ¹, X Xu  ¹, X G He  ¹ （Affiliation ¹ Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Tongji University, Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of ocular fundus diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai University of Traditional Chinese Medicine, School of Public Health, Shanghai 201103, China.）

出处： [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2025

摘要： Objective: To investigate age-related dynamics of refractive compensation for axial elongation in children aged 6-9 years, and examine the modulating ...

作者： Binle Tian ^{#  1   2}, Zhilong Wang ^{#  3}, Mei Cao ^{#  4}, Na Wang ^{#  5}, Xuebing Jia  ^{1   2}, Yuanyuan Zhang  ³, Jingyi Zhou  ¹, Sijia Liu  ⁶, Wen Zhang  ³, Xiao Dong  ¹, Zheng Li  ⁷, Junli Xue  ⁸, JianFei Wang  ^{9   10}, Guo-Huang Fan  ¹¹, Qi Li  ^{12   13} （Affiliations ¹ Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of Oncology, Immunophage Biotech Co., Ltd., 10 Lv Zhouhuang Road, Shanghai, 201114, China. ⁴ Department of Gynecology and Obstetrics, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China. ⁵ Department of Antibody Development, Immunophage Biotech Co., Ltd., 10 Lv Zhouhuang Road, Shanghai, 201114, China. ⁶ Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China. ⁷ Department of Autoimmune Disease, Immunophage Biotech Co., Ltd., 10 Lv Zhouhuang Road, Shanghai, 201114, China. ⁸ Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200123, China. 1310666xuejunli@tongji.edu.cn. ⁹ Excecutive Office, Immunophage Biotech Co., Ltd., 10 Lv Zhouhuang Road, Shanghai, 201114, China. jfwang@immunophage.com.cn. ¹⁰ Shanghai Laboratory Animal Research Center, Shanghai, 201203, China. jfwang@immunophage.com.cn. ¹¹ Excecutive Office, Immunophage Biotech Co., Ltd., 10 Lv Zhouhuang Road, Shanghai, 201114, China. ghfan@immunophage.com.cn. ¹² Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. leeqi@sjtu.edu.cn. ¹³ Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. leeqi@sjtu.edu.cn.）

出处： Journal of experimental & clinical cancer research : CR 2025

关键词： CCR8;IPG0521m;Liver cancer;Single-cell sequencing;Tregs;Tumor microenvironment.

摘要： Background: Regulatory T cells (Tregs) are the main immunosuppressive cells in tumor immune microenvironment (TIME). However, systemic Treg depletion ...

作者： Shitong Zhan ^{#  1}, Feng Chen ^{#  1}, Lijuan Huang  ¹, Lin Chen  ¹, Haoyi Jia  ¹, Shaofei Ma  ², Min Tang  ³, Chongzhi Zhou  ⁴, Yanmin Chen  ⁴, Ye Yang  ¹ （Affiliations ¹ Obstetrics and Gynecology Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Hongkou, Shanghai 200080, China. ² Pathology Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Hongkou, Shanghai 200080, China. ³ Surgery Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Hongkou, Shanghai 200080, China. ⁴ Educational Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Hongkou, Shanghai 200080, China.）

出处： Obstetrics and gynecology international 2025

关键词： BRCA;PARPi;homologous recombination(HRR);ovarian cancer;prognosis.

摘要： Backgrouds: Whether homologous recombination repair (HRR) mutation has a differential effect on the prognosis has not been confirmed by current studie ...

作者： Yuan Wang  ¹, Qian Wu  ¹, Yunyu Zhou  ², Wen Liu  ¹, Wenhong Cao  ¹, Yunwei Fan  ¹, Ningdong Li  ³ （Affiliations ¹ Department of Ophthalmology, Beijing Children's Hospital, Capital Medical University, China. ² Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China.）

出处： SAGE open medicine 2025

关键词： FOXL2;function;genetics.

摘要： Objective: We aimed to investigate the functional alterations caused by pathogenic variants in the FOXL2 gene, a forkhead transcriptional factor. Meth ...

作者： Y Hong  ¹, Q Y Bo  ¹, X D Sun  ¹ （Affiliation ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China.）

出处： [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2025

摘要： Polypoidal choroidal vasculopathy (PCV) is a common subtype of neovascular age-related macular degeneration (nAMD) in Asian populations. Clinical foll ...

作者： Yi Wang¹, Huiqing Wang¹, Chen Ye¹, Zhensheng Zhang¹, Shuxiong Zeng¹, Chuanliang Xu^{1   2} （Affiliations ¹ Department of Urology, Changhai Hospital, Naval Medical University, Shanghai 200433, China. ² Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201613, China.）

出处： Bladder (San Francisco, Calif.) 2025

关键词： Intramural ureter;Kidney-preserving surgery;Transurethral resection of urothelial tumors;Upper urinary tract urothelial carcinoma.

摘要： Background: Ureteral tumors are rare and present unique diagnostic and therapeutic challenges. Objective: This study aimed to evaluate the efficacy an ...

作者： Xiaoting Han  ¹, Lei Fu  ², Liang Li  ³, Jianjun Bian  ³, Mei Zhao  ⁴, Guobin Bi  ⁴ （Affiliations ¹ Department of Oncology, Bengbu Hospital of Shanghai General Hospital, Second Affiliated Hospital of Bengbu Medical University, Bengbu 233020. hxt1231@126.com. ² Department of Hematology, Bengbu Hospital of Shanghai General Hospital, Second Affiliated Hospital of Bengbu Medical University, Bengbu 233020, China. mdbaby1513@163.com. ³ Department of Hematology, Bengbu Hospital of Shanghai General Hospital, Second Affiliated Hospital of Bengbu Medical University, Bengbu 233020, China. ⁴ Department of Oncology, Bengbu Hospital of Shanghai General Hospital, Second Affiliated Hospital of Bengbu Medical University, Bengbu 233020.）

出处： Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 2025

关键词： acquired hemophilia A;activated partial thromboplastin time;cholangiocarcinoma;coagulation factor Ⅷ inhibitor;hemorrhage.

摘要： Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder. Its occurrence secondary to hepatobiliary malignancies is even rarer, and without ...