作者： Xu Xu;Tingting Xiao;Changchang Zhang;Zhiqiang Wang;Gaoming Li;Jingwen Chen;Zhijun Ouyang;Han Wang;Xiangyang Shi;Mingwu Shen （Affiliations ¹ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China. ² College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China. ³ College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China. ⁴ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.）

出处： Biomacromolecules 2023

关键词： ENTRAPPED GOLD NANOPARTICLES;IRON-OXIDE NANOPARTICLES;DRUG-DELIVERY;FACILE FORMATION;BLOOD-POOL;CT;NANOPLATFORM;MICROGELS;SIRNA;ACID

摘要： The development of nanoprobes that have amplified enhanced permeability and retention (EPR) effect is crucial for their precise cancer diagnosis perfo ...

作者： Yuhe Liu;Xueyu Chen;Xuan Deng;Fan Yang;Jinping Zheng;Tianyun Zhou;Ling Xu;Xiaomei Xie;Zhenyu Ju;Baoguo Wang;Caiping Zhang;Yong Zhou （Affiliations ¹ Institute of Biochemistry and Molecular Biology, Hengyang Medical College, University of South China, Hengyang, Hunan, China. ² Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China. ³ Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ The First Affiliated Hospital of Jinan University, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, China. ⁵ Department of Public Health and Preventive Medicine, Changzhi Medical College, Changzhi, China. ⁶ Clinical Medicine, School of Basic Medicine, Shanghai Medical College Fudan University, Shanghai, China. ⁷ Department of Clinical Laboratory, Tangshan Gem Flower Hospital, Tangshan, China. ⁸ Sanbo Brain Hospital, Capital Medical University, Beijing, China.）

出处： Frontiers in endocrinology 2023

关键词： cross-sectional study;metabolic disease;nicotinamide adenine dinucleotide;population;whole blood.

摘要： Background: Nicotinamide adenine dinucleotide (NAD⁺) is a coenzyme and plays a crucial role in several metabolic processes.

作者： Yichao Gan;Chen Wang;Yunyun Chen;Linxin Hua;Hui Fang;Shu Li;Shoujie Chai;Yang Xu;Jiawei Zhang;Ying Gu （Affiliations ¹ Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. ² Institute of Genetics, Department of Genetics, Zhejiang University School of Medicine, Hangzhou 310058, China. ³ Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. ⁴ Department of Oncology, Ningbo First Hospital, Ningbo 315010, China. ⁵ Department of Hematology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China. ⁶ Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China. ⁷ Zhejiang Provincial Key Lab of Genetic and Developmental Disorder, Hangzhou 310058, China. ⁸ Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou 311121, China.）

出处： Pharmaceutics 2023

关键词： cholesterol biosynthesis;hepatocellular carcinoma;methuosis;p38α;tubeimoside 2.

摘要： Liver cancer, consisting mainly of hepatocellular carcinoma, is the third leading cause of cancer-related mortality worldwide. Despite advances in tar ...

作者： Wenwen Jiang;Yue Cheng;Ye Wang;Jing Wu;Zhe Rong;Li Sun;Yan Zhou;Kezhong Zhang （Affiliations ¹ Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. ² Department of Neurology, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, 212000, China. ³ Department of Neurology, Suzhou Ninth People's Hospital, Suzhou, 215200, China. ⁴ Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. nyyxzy@163.com. ⁵ Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. kezhong_zhang1969@126.com.）

出处： Molecular neurobiology 2023

关键词： Gastrointestinal dysfunction;Parkinson’s disease;Phosphorylated α-synuclein;Schwann cells;TLR2-mediated inflammatory pathway.

摘要： The study was designed to investigate the pathogenesis of gastrointestinal (GI) impairment in Parkinson's disease (PD). We utilized 1-methyl-4-phenyl- ...

作者： Yihui Wang;Jizheng Wang;Ling Shi;Xiuyu Chen;Desheng Li;Chen Cui;Kai Yang;Minjie Lu;Jinhua Huang;Lei Zhang;Fei Li;Jinxi Wang;Biyi Chen;Bin Wang;Duane D Hall;Zhenwei Pan;Jiang Hong;Long-Sheng Song;Lei Song;Shihua Zhao （Affiliations ¹ Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, China (Y.W., J. Hong). ² State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (Y.W., Jizheng Wang, X.C., C.C., K.Y., M.L., L.Z., F.L., L.S., S.Z.). ³ Department of Pharmacology, College of Pharmacy, and State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, China (L.S., D.L., Z.P.). ⁴ Department of Cardiology, Fujian Medical University Union Hospital, Fujian Institute of Coronary Heart Disease, China (J. Huang). ⁵ Division of Cardiovascular Medicine, Department of Internal Medicine, Abboud Cardiovascular Research Center (Jinxi Wang, B.C., D.D.H., L.-S.S.), Carver College of Medicine, University of Iowa, Iowa City. ⁶ Department of Cardiology, the First Affiliated Hospital of Shantou University Medical College, Guangdong, China (B.W.). ⁷ Department of Biochemistry and Molecular Biology (L.-S.S.), Carver College of Medicine, University of Iowa, Iowa City. ⁸ Fraternal Order of Eagles Diabetes Research Center (L.-S.S.), Carver College of Medicine, University of Iowa, Iowa City. ⁹ Department of Veterans Affairs Medical Center, Iowa City, IA (L.-S.S.).）

出处： Circulation 2023

关键词： atrial fibrillation;atrial myopathy;calcineurin;calcium and integrin binding 1 (CIB1);calcium and integrin binding 2 (CIB2);fibrosis.

摘要： Background: Atrial fibrillation (AF) is a highly prevalent condition that can cause or exacerbate heart failure, is an important risk factor for strok ...

作者： Jingxiao Du;Tianwei Qian;Yi Lu;Wenkai Zhou;Xun Xu;Chaoyang Zhang;Jingfa Zhang;Zhihua Zhang （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: chaoyang.zhang@shgh.cn. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: 13917311571@139.com. ⁴ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: drzhihuazhang@126.com.）

出处： Experimental cell research 2023

关键词： Extracellular matrix;Fibroblast;Glaucoma;SPARC;YAP;α-SMA.

摘要： Background: Fibrotic scar is a severe side effect of trabeculectomy, resulting in unsatisfactory outcomes for glaucoma surgery. Accumulating evidence ...

作者： Menghao Sun;Yuanhao Shen;Gaozhen Jia;Zheng Deng;Fei Shi;Yifeng Jing;Shujie Xia （Affiliations ¹ Clinical Medical Center of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Institute of Urology, Shanghai Jiao Tong University, Shanghai, China. ³ Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Journal of Cancer 2023

关键词： FRMD6;HNRNPA2B1;Prostate cancer;m6A;miR-93-5p.

摘要： It is becoming increasingly clear that N6-methyladenosine (m6A) plays a key role in post-transcriptional modification of eukaryotic RNAs in cancer. Th ...

作者： Jiang Du;Dan Zhang;Jie Xie;Liu Wang;Yun Xie;Daonan Chen;Xiaoyin She;Jiang Hong;Ruilan Wang （Affiliations ¹ Emergency & Critical Care Department, Shanghai General Hospital of Shanghai Jiaotong University School of Medicine, 650 Xin Songjiang Rd, Shanghai, China. gowindj@163.com. ² Emergency & Critical Care Department, Shanghai General Hospital Jiading Branch of Shanghai Jiaotong University School of Medicine, 800 Huangjiahuayuan RD, 650 Xin Songjiang Rd, Shanghai, China. gowindj@163.com. ³ Emergency & Critical Care Department, Shanghai General Hospital of Shanghai Jiaotong University School of Medicine, 650 Xin Songjiang Rd, Shanghai, China. ⁴ Emergency & Critical Care Department, Shanghai General Hospital Jiading Branch of Shanghai Jiaotong University School of Medicine, 800 Huangjiahuayuan RD, 650 Xin Songjiang Rd, Shanghai, China. ⁵ Emergency & Critical Care Department, Shanghai General Hospital Jiading Branch of Shanghai Jiaotong University School of Medicine, 800 Huangjiahuayuan RD, 650 Xin Songjiang Rd, Shanghai, China. 18917444639@163.com. ⁶ Emergency & Critical Care Department, Shanghai General Hospital of Shanghai Jiaotong University School of Medicine, 650 Xin Songjiang Rd, Shanghai, China. jhong.pku@163.com.）

出处： Internal and emergency medicine 2023

关键词： Acute kidney injury;Acute renal failure;Body mass index;Obesity;Rehydration volume;Survival.

摘要： Rehydration volume may be underestimated in obese critically ill patients, which can lead to acute kidney injury (AKI). This study aimed to investigat ...

作者： Jiawei Lu;Lanting Yu;Ni Xie;Ying Wu;Baiwen Li （Affiliation ¹ Department of Gastroenterology, Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.）

出处： Journal of Cancer 2023

关键词： IGF2BP2;LINC00941;METTL14;N6-methyladenosine;metastasis;pancreatic carcinoma.

摘要： Pancreatic adenocarcinoma (PC), one of the most fatal diseases, usually generates a poor prognosis in advanced stages. N6-methyladenosine modification ...

作者： Chao Xia;Yonghui Wang;Tianyuan Jiang;Yan Hu;Yang Chen;Xinrun Ma;Xuemei Zhang;Yanhong Gao （Affiliations ¹ Department of Geriatrics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Geriatrics, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.）

出处： Journal of cachexia, sarcopenia and muscle 2023

关键词： Muscle regeneration;Myoblast;Myogenesis;Skeletal muscle;Slo1;Slow-twitch fibre formation.

摘要： Background: It has been observed that Slo1 knockout mice have reduced motor function, and people with certain Slo1 mutations have movement problems, b ...