作者： Li Zhang ^{1 2}, Naihui Zhou ³, Zhouwei Wu ⁴, Xuejun Chen ⁵, Huilan Zhu ⁶, Shanshan Li ⁷, Jianwen Han ⁸, Guoying Miao ⁹, Liming Wu ¹⁰, Rongfei Zhu ¹¹, Jianyun Lu ¹², Yue Zheng ¹³, Xian Jiang ¹⁴, Xianwei Cao ¹⁵, Dehou Yu ¹⁶, Siping Zhang ¹⁷, Yangfeng Ding ¹⁸, Xiaoyong Man ¹⁹, Yong Cui ²⁰, Ying Li ²¹, Xia Dou ²², Xinghua Gao ^{23 24} （Affiliations ¹ The First Hospital of China Medical University, Liaoning, China. ² Key Laboratory of Immunodermatology, Ministry of Education and NHC, National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Liaoning, China. ³ The First Affiliated Hospital of Soochow University, Suzhou, China. ⁴ Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. ⁵ Sichuan Provincial People's Hospital, Chengdu, China. ⁶ Guangzhou Dermatology Hospital, Guangzhou, China. ⁷ First Hospital of Jilin University, Changchun, China. ⁸ The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China. ⁹ Affiliated Hospital of Hebei University of Engineering, Handan, China. ¹⁰ Hangzhou First People's Hospital, Hangzhou, China. ¹¹ Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China. ¹² The Third Xiangya Hospital of Central South University, Changsha, China. ¹³ Nanfang Hospital, Southern Medical University, Guangzhou, China. ¹⁴ West China Hospital of Sichuan University, Chengdu, China. ¹⁵ The First Affiliated Hospital of Nanchang University, Nanchang, China. ¹⁶ The Affiliated Hospital of Guizhou Medical University, Guizhou, China. ¹⁷ The First Affiliated Hospital of USTC, Hefei, China. ¹⁸ Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. ¹⁹ The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. ²⁰ China-Japan Friendship Hospital, Beijing, China. ²¹ Qilu Hospital of Shandong University, Jinan, China. ²² Peking University Shenzhen Hospital, Shenzhen, China. ²³ The First Hospital of China Medical University, Liaoning, China. xhgao@cmu.edu.cn. ²⁴ Key Laboratory of Immunodermatology, Ministry of Education and NHC, National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Liaoning, China. xhgao@cmu.edu.cn.）

出处： Dermatology and therapy 2026

关键词： Abrocitinib;Adult;Atopic;China;Dermatitis;Real-world;Registry.

摘要： Introduction: Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition that significantly impairs quality of life (QoL) and imposes ...

作者： Chun Xiang Tang ¹, Jonathon A Leipsic ², Bjarne L Nørgaard ³, Pontone Gianluca ^{4 5}, Christian Tesche ^{6 7 8}, Junjie Yang ⁹, Bon-Kwon Koo ¹⁰, Carlos Collet ¹¹, Mouaz H Al-Mallah ¹², Lei Xu ¹³, Jia Yin Zhang ¹⁴, Neng Dai ^{15 16 17 18}, Guang Ming Lu ¹, Min Wen Zheng ¹⁹, Long Jiang Zhang ²⁰, U Joseph Schoepf ^{21 22} （Affiliations ¹ Department of Radiology, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, Jiangsu, China. ² Providence Health Care, Department of Radiology, University of British Columbia, Vancouver, BC, Canada. ³ Department of Cardiology, Aarhus University Hospital Skejby, Aarhus, Denmark. ⁴ Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCCS, Milan, Italy. ⁵ Department of Biomedical, Surgical, and Dental Sciences, University of Milan, Milan, Italy. ⁶ Department of Cardiology, Clinic Augustinum Munich, 16 Wolkerweg, 81375, München, Germany. ⁷ Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, Lazarettstraße 36, 80636, München, Germany. ⁸ Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Drive, Charleston, South Carolina, 29425, USA. ⁹ Department of Cardiology, Chinese PLA General Hospital, Beijing, China. ¹⁰ Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea. ¹¹ Cardiovascular Center Aalst, OLV Clinic, Aalst, Belgium. ¹² Houston Methodist Hospital, 6565 Fannin St, Houston, TX, 77030, USA. ¹³ Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, 10029, Beijing, China. ¹⁴ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁵ Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai, China. ¹⁶ State Key Laboratory of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. ¹⁷ NHC Key Laboratory of Ischemic Heart Diseases, Shanghai, China. ¹⁸ National Clinical Research Center for Interventional Medicine, Shanghai, China. ¹⁹ Department of Cardiology, Xijing Hospital, Fourth Military Medical University, 710032, Xi'an, Shaanxi, China. ²⁰ Department of Radiology, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, Jiangsu, China. kevinzhlj@163.com. ²¹ Department of Radiology, Jinling Hospital, Medical School of Nanjing University, 210002, Nanjing, Jiangsu, China. dr.schoepf@gmail.com. ²² Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, MSC 226, 25 Courtenay Drive, Charleston, South Carolina, 29425, USA. dr.schoepf@gmail.com.）

出处： European radiology 2026

关键词： Computed tomography angiography;Coronary angiography;Coronary artery disease;Fractional flow reserve, Myocardial.

摘要： Objectives: Coronary computed tomography angiography (CCTA)-derived fractional flow reserve (CT-FFR) has emerged as a critical tool for assessing func ...

作者： Yi-Zhe Ren¹;Ming-Na Zhao¹;Feng-Lin Du²;Lei Wu¹;Lin Wang¹CA1;null;Jia-Tao Lou¹CA2 （¹Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²School of Life Sciences, Bengbu Medical University, Bengbu, China）

出处： Oncogene 2026

摘要： Bone metastasis is a devastating complication of non-small cell lung cancer (NSCLC), critically impairing patient survival. Nevertheless, the underlyi ...

作者： Tianhui Hou^{1,2 na1};Huaze Ding^{2 na1};Guofang Huang^{1,2 na1};Tong Meng² & …Dianwen Song^1,2 （¹University of Shanghai for Science and Technology, Shanghai, 200093, China;²Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China）

出处： Cellular Oncology 2026

关键词： Cancer neuroscience;Neural-tumor crosstalk;Tumor microenvironment;Neurotransmitters;Glial cells;Targeted therapy

摘要： The nervous system is increasingly recognized as a key regulator of the tumor microenvironment, engaging in bidirectional crosstalk with cancer cells ...

作者： Shu Li^{1 na1};Linying An^{1 na1};Shuai Shao²;Tong Wei²;Yin Tong¹ & …Yin Tong¹ （¹Department of Hematology, Shanghai General HospitalShanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China;²Department of Cardiology, Shanghai General Hospital, Shanghai Jiao tong University School of medicine, No.100 Haining Road, Shanghai, 200080, China）

出处： Clinical and Experimental Medicine 2026

关键词： Alternative splicing;Acute myeloid leukemia;TCGA;SpliceSeq;Prognosis

摘要： Alternative splicing (AS) plays critical roles in acute myeloid leukemia (AML), but the prognostic values of AS events are rarely studied. In this stu ...

作者： Peiyu Liu^1,2;Ning Shen^1,2;Yali Zhou^1,2;Jingyi Wu^3,2;Meng Hao³;Shuchang Zhang¹;Yifan Wang¹;Xiaoqian Wang¹;Huiming Li⁴;Zhipeng You⁵;Huimin Fan⁵;Xun Xu¹CA1;Ning Wang⁶CA2;Dandan Sun¹CA3;Fang Wei¹CA4 （¹Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China;²These authors contributed equally to this work.;³Human Phenome Institute, Zhangjiang Fudan International Innovation Centre, Fudan University, Shanghai, China;⁴Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁵The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China;⁶Shanghai Eye Diseases Prevention and Treatment Center/Shanghai Eye Hospital, School of Medicine, Tongji University, Shanghai, China）

出处： Metabolism 2026

摘要： Background Endothelial cell (EC) senescence is a key contributor to retinal vascular dysfunction in diabetic retinopathy (DR), yet its molecular mecha ...

作者： Yihang Cai^1,2;Yongyi Chen^3,2;Xiqin Bian^1,2;Changlin Sun^1,2;Jing Cheng^4,5;Haibo Liu⁴;Lai Jin¹CA1;Jianxin Ma⁶CA2;Wentao Liu¹CA3 （¹Department of Pharmacology, Nanjing Medical University, Nanjing, China;²First author;³Department of Anesthesiology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China;⁴Department of gastroenterology, Lianyungang municipal oriental hospital, Lianyungang, China;⁵Department of gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China;⁶Lianyungang Municipal Oriental Hospital, Lianyungang, China）

出处： International Immunopharmacology 2026

关键词： Gut-liver axis;Chemotherapy-induced steatohepatitis;Neutrophil extracellular traps;Fucoidan;Irinotecan

摘要： Chemotherapy-associated hepatotoxicity represents a critical limitation in cancer treatment, decreasing patient survival and quality of life. Irinotec ...

作者： Duan Lu Hou^1,21;Yun-Cheng Wu²CA2;Eng King Tan^1,3,4CA3;Zhi Dong Zhou^1,4CA4 （¹National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore;²Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.86, Wujin Road, Shanghai 200080, China;³Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore;⁴Signature Research Program in Neuroscience and Behavioral Disorders, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore）

出处： Ageing Research Reviews 2026

摘要： The blood-brain barrier (BBB) is crucial for brain homeostasis, and its dysfunction is associated with aging and neurodegenerative diseases. A recent ...

作者： Zhiying Yue  ¹, Wentao Dai  ², Zhuoran Cao  ³, Bin Hu  ⁴, Ziyuan Wang  ³, Xinrun Ma  ³, Da Qin  ³, Taiyu Zhang  ³, Qingqing Sang  ⁵, Jing Mei  ³, Tianci Yu  ³, Yong Zhou  ³, Zai Luo  ⁶, Junming Xu  ⁶, Zengjin Yuan  ⁷, Yuan-Yuan Li  ⁸, Jinyan Zhang  ⁹, Chen Huang  ¹⁰, Zhengfeng Yang  ³ （Affiliations ¹ East China Normal University Shanghai, Shanghai China. ² Shanghai Institute for Biomedical and Pharmaceutical Technologies China. ³ Precision Research Center for Refractory Diseases Shanghai China. ⁴ Shanghai Jiao Tong University Shanghai China. ⁵ Ruijin Hospital Shanghai China. ⁶ Shanghai General Hospital China. ⁷ Novopathway Biotechnology China. ⁸ Shanghai Institute for Biomedical and Pharmaceutical Technologies Shanghai China. ⁹ Shanghai Jiao Tong University China. ¹⁰ Shanghai First People's Hospital Shanghai China.）

出处： Cancer research 2026

摘要： G protein-coupled receptors (GPCRs) are increasingly recognized for their organelle-specific functions in cancer. A better understanding of the mechan ...

作者： Mao Li ¹, Yaqi Chen ², Anyi Liu ³, Qi Wu ¹, Changsheng Huang ¹, Da Song ¹, Fuqing Hu ¹, Jingqin Lan ⁴, Chen Huang ⁵, Junbo Hu ², Guihua Wang ¹ （Affiliations ¹ Tongji Hospital Wuhan China. ² Tongji Hospital, Tongji Medical College Wuhan China. ³ Tongji Hospital, Tongji Medical College Wuhan, Hubei China. ⁴ Tongji Hospital affiliated to Tongji Medical Colle Wuhan, Hubei China. ⁵ Shanghai First People's Hospital Shanghai China.）

出处： Cancer research 2026

摘要： Regulatory T cells (Tregs) within the tumor microenvironment critically undermine the efficacy of PD-1 immune checkpoint blockade. Metabolic reprogram ...