作者： Guiping Kong  ¹, Yayue Song  ¹, Yuyang Yan  ¹, Samantha M Calderazzo  ², Madhu Sudhana Saddala  ³, Fabian De Labastida Rivera  ⁴, Jonathan D Cherry  ², Noah Eckman  ⁵, Eric A Appel  ⁵, Adam Velenosi  ⁶, Vivek Swarup  ³, Riki Kawaguchi  ⁷, Susanna S Ng  ⁸, Brian K Kwon  ⁹, David Gate  ¹⁰, Christian R Engwerda  ⁴, Luming Zhou  ¹¹, Simone Di Giovanni  ¹² （Affiliations ¹ Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK. ² Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Boston University Alzheimer's Disease and CTE Centers, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. ³ Department of Neurobiology and Behaviour, School of Biological Sciences, University of California Irvine, Irvine, CA, USA. ⁴ QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. ⁵ Department of Chemical Engineering, Stanford University, Stanford, CA, USA; Department of Materials Science & Engineering, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Paediatrics, Endocrinology, Stanford University, Stanford, CA, USA; ChEM-H Institute, Stanford University, Stanford, CA, USA; Woods Institute for the Environment, Stanford University, Stanford, CA, USA. ⁶ International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Praxis Spinal Cord Institute, Vancouver, BC, Canada. ⁷ Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Semel Institute for Neuroscience and Human Behaviour, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ⁸ QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Institute of Experimental Oncology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany. ⁹ International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada. ¹⁰ The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ¹¹ Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK; Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: l.zhou13@imperial.ac.uk. ¹² Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK. Electronic address: s.di-giovanni@imperial.ac.uk.）

出处： Neuron 2025

关键词： CD8(+) T cells;NKG7;NKLT cells;aging;granzyme K;regeneration;repair;spinal cord injury;wound healing.

摘要： Spinal cord injury (SCI) increasingly affects aged individuals, where functional impairment and mortality are highest. However, the aging-dependent me ...

作者： Pengfei Zan ^{#  1}, Yi Zhang ^{#  2}, Yidong Zhu ^{#  3}, Qingjing Chen  ⁴, Zhengwei Duan  ², Yonghao Guan  ², Kaiyuan Liu  ⁵, Anquan Shang  ⁶, Zihua Li  ⁷ （Affiliations ¹ Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. ² Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. ³ Department of Traditional Chinese Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. ⁴ Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510630, China. ⁵ Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. liuky2019@163.com. ⁶ Department of Laboratory Medicine, The Second People's Hospital of Lianyungang, Bengbu Medical College, Lianyungang, 222006, China. shanganquan@tongji.edu.cn. ⁷ Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. lizihua@tongji.edu.cn.）

出处： Discover oncology 2025

关键词： Aging;Cellular senescence;Sarcoma;Tumor microenvironment.

摘要： Sarcoma (SARC), a diverse group of stromal tumors arising from mesenchymal tissues, is often associated with a poor prognosis. Emerging evidence indic ...

作者： Yichao Ma  ^{1   2}, Jiangpeng Wu  ², Yanlong Dong  ³, Hongmei Tang  ¹, Xiaojun Ma  ² （Affiliations ¹ Shanghai University of Traditional Chinese Medicine, Shanghai, China. ² Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Linyan Medical Technology Company Limited, Shanghai, China.）

出处： Orthopaedic surgery 2025

关键词： accuracy;augmented reality;navigation;pedicle screw;thoracolumbar spine.

摘要： Objective: The pedicle screw insertion technique has evolved significantly, and despite the challenges of precise placement, advancements like AR-base ...

作者： Fan Yang  ^{1   2   3}, Yang Gao  ^{1   2   3}, Bing Han  ^{1   2   3}, Wen Zhu  ^{1   2   3}, Guanxiong Wang  ^{1   2   3}, Liting Liu  ^{1   2   3}, Qunshan Shen  ^{1   4   5}, Bing Song  ^{1   2   3}, Mingrong Lv  ^{1   2   6}, Huan Wu  ^{1   2   3}, Dongdong Tang  ^{1   2   3}, Ping Zhou  ^{1   2   3}, Zhaolian Wei  ^{1   2   3}, Yuping Xu  ^{1   2   3}, Yunxia Cao  ^{1   2   3   6}, Xiaojin He  ^{1   2   7} （Affiliations ¹ Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. ² NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, China. ³ Engineering Research Center of Biopreservation and Artificial Organs, Hefei, China. ⁴ Anhui Provincial Institute of Translational Medicine, Hefei, China. ⁵ Anhui Provincial Human Sperm Bank, The First Affiliated Hospital of Anhui Medical University, Hefei, China. ⁶ Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, China. ⁷ Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Andrology 2025

关键词： CDYL;aberrant acetylation;asthenoteratozoospermia;male infertility;splicing mutation.

摘要： Objectives: Acetylated tubulin is a hallmark of flagellar stability in spermatozoa, and studies have demonstrated the ability of CDYL to function as a ...

作者： Yi-Bang Cheng  ¹, De-Wei An  ^{1   2   3}, Lucas S Aparicio  ⁴, Qi-Fang Huang  ¹, Yu-Ling Yu  ^{2   3}, Chang-Sheng Sheng  ¹, Teemu J Niiranen  ^{5   6}, Fang-Fei Wei  ⁷, José Boggia  ⁸, Katarzyna Stolarz-Skrzypek  ⁹, Natasza Gilis-Malinowska  ¹⁰, Valérie Tikhonoff  ¹¹, Wiktoria Wojciechowska  ⁹, Edoardo Casiglia  ¹¹, Krzysztof Narkiewicz  ¹⁰, Wen-Yi Yang  ¹², Jan Filipovský  ¹³, Kalina Kawecka-Jaszcz  ⁹, Ji-Guang Wang  ¹, Tim S Nawrot  ³, Yan Li  ¹, Jan A Staessen  ^{1   2   14   15}; International Database of Central Arterial Properties for Risk Stratification (IDCARS) Investigators （Affiliations ¹ Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. ² Non-Profit Research Association Alliance for the Promotion of Preventive Medicine, Leuven, Belgium. ³ Research Unit Environment and Health, Department of Public Health and Primary Care, University of Leuven, Leuven, Belgium. ⁴ Servicio de Clínica Médica, Sección Hipertensión Arterial, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. ⁵ Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Turku, Finland. ⁶ Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland. ⁷ Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China. ⁸ Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay. ⁹ First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland. ¹⁰ Hypertension Unit, Department of Hypertension and Diabetology, Medical University of Gdańsk, Gdańsk, Poland. ¹¹ Department of Medicine, University of Padua, Padua, Italy. ¹² Department of Cardiology, Shanghai General Hospital, Shanghai, China. ¹³ Faculty of Medicine, Charles University, Pilsen, Czech Republic. ¹⁴ Research Institute Alliance for the Promotion of Preventive Medicine, Mechelen, Belgium. ¹⁵ Biomedical Sciences Group, Faculty of Medicine, University of Leuven, Leuven, Belgium.）

出处： Journal of clinical hypertension (Greenwich, Conn.) 2025

关键词： cardiovascular risk;mortality;population science;pulse wave transit time;waveform analysis.

摘要： Prognostic significance of the timing in the cardiac cycle of the first (TP1) and second (TP2) systolic peak of the central aortic pulse wave is ill-d ...

作者： Dao-Cheng Fang  ^{1   2}, Yuan-Yuan Hu  ³, Chao Wang  ¹, Jie Fan  ⁴, Hui Wen  ⁵ （Affiliations ¹ Department of Urology, Songjiang hospital affiliated to Shanghai jiaotong university school of medicine, Shanghai, China. ² Department of Urology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. ³ Department of General Practice, Songjiang hospital affiliated to Shanghai jiaotong university school of medicine, Shanghai, China. ⁴ Department of Urology, School of Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, China. jief67@sina.com. ⁵ Department of Urology, Songjiang hospital affiliated to Shanghai jiaotong university school of medicine, Shanghai, China. whsimon2000@aliyun.com.）

出处： Scientific reports 2025

关键词： Blue light;Brain-kidney axis;Kidney stones;Oxidative stress.

摘要： Kidney stones, a common urological disease, may involve the brain-kidney axis in their formation, though the specific mechanism remains unclear. This ...

作者： Yiting Li MS¹;Xi Tan MS¹;Shu Nie MD¹;Bin Chen MS¹;Chaoshuai Zhao MS¹;Ran Liu MD¹;Zhouwei Wu PhD¹CA1 （¹Department of Dermatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Journal of the American Academy of Dermatology 2025

作者： Penglin Zou ^{#  1}, Gaoxiang Fan ^{#  1}, Zheng Li  ², Yuchen Tao  ^{1   3}, Chao Jia  ¹, Hongmei Liang  ¹, Ruhui Tian  ², Qiusheng Shi  ¹, Jianlin Hu  ⁴, Rong Wu  ⁵ （Affiliations ¹ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Department of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of Ultrasound, Huadong Hospital, Fudan University, Shanghai, 200040, China. ⁴ Department of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. hello570@126.com. ⁵ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. wurong7111@163.com.）

出处： Basic and clinical andrology 2025

关键词： Contrast-enhanced ultrasound;Hemodynamics;Male infertility;Varicocele.

摘要： Background: Hemodynamic alterations in the spermatic vein are implicated in infertility among patients with varicocele (VC). Contrast-enhanced ultraso ...

作者： Shan Liu  ¹, Siyu Tong  ², Guodong Liu  ², Shiping Wang  ², Kundong Zhang  ³, Zhengjun Qiu  ⁴ （Affiliations ¹ Department of General Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China; The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian 223800, Jiangsu, China. ² The Affiliated Suqian First People's Hospital of Nanjing Medical University, Suqian 223800, Jiangsu, China. ³ Department of General Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China; Department of General Surgery, Jiuquan Branch of Shanghai General Hospital, Gansu 735099, China. Electronic address: zkd881006@163.com. ⁴ Department of General Surgery, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China; Department of General Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China. Electronic address: zhengjun.qiu@shgh.cn.）

出处： International journal of biological macromolecules 2025

关键词： Colon cancer;Hyaluronic acid;Nanoparticles.

摘要： Colon cancer (CC) is the third most common cancer globally and one of the leading causes of death. Therefore, there is an urgent need to develop an ef ...

作者： Xin Zhou  ¹, Yuqing Zhao  ², Shixue Huang  ¹, Haoming Shu  ^{3   4}, Yinuo Zhang  ¹, Haiyuan Yang  ^{3   4}, Yilong Ren  ^{3   4}, Xuhui Zhou  ^{1   4}, Wei Liu  ¹, Tengfei Song  ¹, Jianquan Zhao  ¹, Jun Ma  ^{3   4} （Affiliations ¹ Department of Orthopedics, Changzheng Hospital, The Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. ² Department of Neurosurgery, Changzheng Hospital, The Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. ³ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁴ Translational Research Centre of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.）

出处： International journal of biological sciences 2025

关键词： GPX4;TRIM32;autophagic degradation;neuronal ferroptosis;ubiquitination.

摘要： Ferroptosis, characterized by iron-dependent phospholipid peroxidation, is recognized as one of the cell death pathways activated following spinal cor ...