作者： Shubin Zhang ^{#  1   2   3}, Zhongyi Jiang ^{#  1   2   3}, Pusen Wang ^{#  1   2   3}, Weihao Jiang  ³, Wei Ding  ⁴, Lin Zhong  ^{5   6   7} （Affiliations ¹ Department of Hepatobiliary & Pancreatic Surgery, The First Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang People's Hospital, Shandong Second Medical University, No. 151 Guangwen Street, Weifang, 261041, Shandong, China. ² Department of General Surgery, The Third People's Hospital of Shenzhen, The Second Hospital Affiliated of Southern University of Science and Technology, Guangdong, China. ³ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Hepatobiliary & Pancreatic Surgery, The First Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang People's Hospital, Shandong Second Medical University, No. 151 Guangwen Street, Weifang, 261041, Shandong, China. dingweigdwk@163.com. ⁵ Department of Hepatobiliary & Pancreatic Surgery, The First Affiliated Hospital of Shandong Second Medical University, School of Clinical Medicine, Weifang People's Hospital, Shandong Second Medical University, No. 151 Guangwen Street, Weifang, 261041, Shandong, China. zhonglin1@medmail.com.cn. ⁶ Department of General Surgery, The Third People's Hospital of Shenzhen, The Second Hospital Affiliated of Southern University of Science and Technology, Guangdong, China. zhonglin1@medmail.com.cn. ⁷ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhonglin1@medmail.com.cn.）

出处： Discover oncology 2024

关键词： Immune Infiltration4;Liver hepatocellular carcinoma2;Prognostic biomarker3;TCBIR/CD3201;Tumor angiogenesis5.

摘要： CD320, which is a transmembrane protein responsible for facilitating the absorption of vitamin B12, plays a key role in this process. However, the rel ...

作者： Luyan Bian  ¹, Yuchao Niu  ², Weijie Yuan  ³, Huasheng Du  ¹, Yitong Yang  ¹ （Affiliations ¹ Department of Nephrology, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China. ² Department of Oncology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, China. ³ Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School, Shanghai, China.）

出处： Renal failure 2024

关键词： CD4+ T cells;HBx;immune responses;inflammatory responses;macrophages;podocytes.

摘要： Background: Podocytes, as intrinsic renal cells, can also express MHC-II and costimulatory molecules under inflammatory conditions, suggesting that th ...

作者： Zhicong Yang ^{#  1}, Qing Chen ^{#  2}, Shihua Dong ^{#  1   3}, Peng Xu ^{#  1   3}, Wanxiang Zheng  ⁴, Zhanrui Mao  ¹, Chengchen Qian  ³, Xiangyi Zheng  ³, Lihe Dai  ², Chengyang Wang  ³, Haoqing Shi  ², Jing Li  ⁵, Jianlin Yuan  ⁶, Wenqiang Yu  ⁷, Chuanliang Xu  ^{8   9} （Affiliations ¹ Shanghai Public Health Clinical Center and Department of General Surgery, Huashan Hospital and Cancer Metastasis Institute and Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. ² Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China. ³ Shanghai Epiprobe Biotechnology Co., Ltd, Shanghai, China. ⁴ Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, China. ⁵ Department of Bioinformatics, Center for Translational Medicine, Naval Medical University, Shanghai, China. ⁶ Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi, China. jianliny@fmmu.edu.cn. ⁷ Shanghai Public Health Clinical Center and Department of General Surgery, Huashan Hospital and Cancer Metastasis Institute and Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. wenqiangyu@fudan.edu.cn. ⁸ Department of Urology, Changhai Hospital, Naval Medical University, Shanghai, China. chuanliang_xu@126.com. ⁹ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. chuanliang_xu@126.com.）

出处： Journal of translational medicine 2024

摘要： Background: Urothelial carcinoma (UC) is the second most common urological malignancy. Despite numerous molecular markers have been evaluated during t ...

作者： Zhengqing Yu  ¹, Yong Zhou  ², Kehang Mao  ¹, Bo Pang  ³, Kai Wang  ⁴, Tang Jin  ⁴, Haonan Zheng  ¹, Haotian Zhai  ¹, Yiyang Wang  ¹, Xiaohan Xu  ⁵, Hongxiao Liu  ⁵, Yi Wang  ⁶, Jing-Dong J Han  ⁷ （Affiliations ¹ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, China. ² Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Clinical Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ⁴ International Center for Aging and Cancer (ICAC), Hainan Medical University, Haikou, China. ⁵ Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. ⁶ Kailuan Majiagou Hospital, Tangshan, Hebei Province, China. ⁷ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, China; International Center for Aging and Cancer (ICAC), Hainan Medical University, Haikou, China; Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Chengdu, China. Electronic address: jackie.han@pku.edu.cn.）

出处： Cell metabolism 2024

关键词： aging;aging clock;aging marker;body temperature;disease detection;facial phenotype;facial temperature;metabolic disorder;quantitative analysis;thermal infrared imaging.

摘要： Although human core body temperature is known to decrease with age, the age dependency of facial temperature and its potential to indicate aging rate ...

作者： Yanlu Du  ^{1   2}, Ying Zhang  ^{1   2}, Xiaowei Xu  ^{1   2}, Yu Cai  ^{1   2}, Yu Wei  ^{1   2}, Chongmei Huang  ^{1   2}, Jun Yang  ^{1   2}, Huiying Qiu  ^{1   2}, Jiahua Niu  ^{1   2}, Kun Zhou  ^{1   2}, Xinxin Xia  ^{1   2}, Chang Shen  ^{1   2}, Yin Tong  ^{1   2}, Baoxia Dong  ^{1   2}, Liping Wan  ^{3   4}, Xianmin Song  ^{5   6} （Affiliations ¹ Department of Hematology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China. ² Engineering Technology Research Center of Cell Therapy and Clinical Translation, Shanghai Science and Technology Committee (STCSM), No.100 Haining Road, Shanghai, 200080, China. ³ Department of Hematology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China. lipingwan@sjtu.edu.cn. ⁴ Engineering Technology Research Center of Cell Therapy and Clinical Translation, Shanghai Science and Technology Committee (STCSM), No.100 Haining Road, Shanghai, 200080, China. lipingwan@sjtu.edu.cn. ⁵ Department of Hematology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China. shongxm@sjtu.edu.cn. ⁶ Engineering Technology Research Center of Cell Therapy and Clinical Translation, Shanghai Science and Technology Committee (STCSM), No.100 Haining Road, Shanghai, 200080, China. shongxm@sjtu.edu.cn.）

出处： Annals of hematology 2024

关键词： Anti-thymocyte Globulin;Cyclophosphamide;Haploidentical peripheral blood stem cell transplantation;Pediatric.

摘要： The low-dose anti-thymocyte globulin (ATG) plus low-dose post transplantation cyclophosphamide (PTCy) -based (low-dose ATG/PTCy-based) regimen had a p ...

作者： Min Wang  ¹, Zhaohui Huang  ¹, Xin Li  ², Ping He  ¹, He Sun  ³, Yali Peng  ¹, QiuLing Fan  ⁴ （Affiliations ¹ Department of Nephrology, First Hospital of China Medical University, Shenyang, Liaoning, China. ² Department of Nephrology, Fourth Hospital of China Medical University, Shenyang, Liaoning, China. ³ Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. ⁴ Department of Nephrology, First Hospital of China Medical University, Shenyang, Liaoning, China; Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: cmufql@163.com.）

出处： Pharmacological research 2024

关键词： Apabetalone;Diabetic kidney disease;NLRP3 inflammasome;Pyroptosis.

摘要： Many inflammatory disorders, including diabetic kidney disease (DKD), are associated with pyroptosis, a type of inflammation-regulated cell death. The ...

作者： Xiangxiao Li ^{#  1   2}, Hong Zhou ^{#  2}, Pengfei Lu  ², Zilong Fang  ¹, Guangzheng Shi  ¹, Xinran Tong  ¹, Wendong Chen  ¹, Gonghao Jiang  ¹, Peili Zhang  ¹, Jingyan Tian  ^{3   4}, Qun Li  ⁵ （Affiliations ¹ The Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension,, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China. ² Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ³ Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital,, Shanghai Jiao Tong University School of Medicine, Shanghai, China. tianjypaper@163.com. ⁴ Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Clinical Trials Center, Ruijin Hospital,, Shanghai Jiao Tong University School of Medicine, Shanghai, China. tianjypaper@163.com. ⁵ The Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension,, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, China. liqun@sibs.ac.cn.）

出处： Cardiovascular diabetology 2024

关键词： Angiotensin II;Blood pressure;Cebpα;Treg cells;miPEP31.

摘要： Background: Previous studies have shown that peptides encoded by noncoding RNAs (ncRNAs) can be used as peptide drugs to alleviate diseases. We found ...

作者： Shaojian Lin  ^{1   2   3}, Liangbo Wang  ², Changxi Han  ¹, Yuting Dai  ⁴, Changsheng Li  ¹, Yanting Liu  ¹, Bo Zhang  ¹, Ning Huang  ², Anke Zhang  ⁵, Tao Zhang  ², Yu Wang  ⁶, Jing Xie  ⁷, Hao Tang  ¹, Yijun Cheng  ¹, Hong Yao  ¹, Meiqing Lou  ⁸, Li Xue  ^{1   3}, Zhe Bao Wu  ^{1   2   3} （Affiliations ¹ Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. ³ Department of Neurosurgery, Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. ⁶ Department of Neurosurgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁸ Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Neuro-oncology 2024

关键词： Cabergoline;Gαq/PLC/PKC-γ;HTR2B;Pituitary adenomas;STAT3.

摘要： Background: Managing non-functioning pituitary adenomas (NFPAs) is difficult due to limited drug treatments. Cabergoline's (CAB) effectiveness for NFP ...

作者： Zheng Chen¹;Mincheng Yu¹;Bo Zhang¹;Lei Jin¹;Qiang Yu¹;Shuang Liu²;Binghai Zhou³;Jiuliang Yan⁴;Wentao Zhang¹;Xiaoqiang Li⁵;Yongfeng Xu¹;Yongsheng Xiao¹;Jian Zhou¹;Jia Fan¹;Mien-Chie Hung⁶CA;Qinghai Ye¹CA;Hui Li⁷CA;Lei Guo¹CA （¹a Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China;²b Neurosurgery Department of Zhongshan Hospital, Fudan University, Shanghai, P.R. China;³c Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, P.R. China;⁴d Department of Pancreatic Surgery, Shanghai General Hospital and Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China;⁵e Department of Thoracic Surgery, Peking University Shenzhen Hospital, Shenzhen, P.R. China;⁶f Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung, TX, Taiwan;g Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;⁷a Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China;h Shanghai Medical College and Zhongshan Hospital Immunotherapy Translational Research Center, Shanghai, P.R. China）

出处： OncoImmunology 2024

关键词： Immune checkpoints;immune evasion;liver cancer;survival signaling;tumor microenvironment

摘要： Functional roles of SIGLEC15 in hepatocellular carcinoma (HCC) were not clear, which was recently found to be an immune inhibitor with similar structu ...

作者： Kankan Zhao  ¹, Yanjie Zhu  ², Xiuyu Chen  ³, Shujuan Yang  ³, Weipeng Yan  ³, Kai Yang  ³, Yanyan Song  ³, Chen Cui  ³, Xi Xu  ³, Qingyong Zhu  ², Zhuo-Xu Cui  ², Gang Yin  ³, Huaibin Cheng  ², Minjie Lu  ², Dong Liang  ², Ke Shi  ⁴, Lei Zhao  ⁵, Hui Liu  ⁶, Jiayin Zhang  ⁷, Liang Chen  ³, Sanjay K Prasad  ⁸, Shihua Zhao  ⁹, Hairong Zheng  ¹⁰ （Affiliations ¹ Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China; Shenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Beijing, China. ² Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China. ³ State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ⁴ Department of Radiology, West China Hospital of Sichuan University, Chengdu, China. ⁵ Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. ⁶ Department of Radiology, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China. ⁷ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁸ Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital, London, United Kingdom; National Heart and Lung Institute, Imperial College, London, United Kingdom. ⁹ State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: cjrzhaoshihua2009@163.com. ¹⁰ Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, SZ University Town, Shenzhen, China. Electronic address: hr.zheng@siat.ac.cn.）

出处： JACC. Cardiovascular imaging 2024

关键词： cardiac magnetic resonance;hypertrophic cardiomyopathy;machine learning;risk model.

摘要： Background: The cumulative burden of hypertrophic cardiomyopathy (HCM) is significant, with a noteworthy percentage (10%-15%) of patients with HCM per ...