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作者: Yihan Zhang  1, Xin Xie  2, Hong Zhou  1, Bingxin Li  1, Li Ding  3, Zhaogen Cai  3, Huaidong Song  4, Shuangxia Zhao  4, Huanbai Xu  1 (Affiliations 1 Department of Endocrinology and Metabolism, Center for Microbiota and Immunological Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Endocrinology and Metabolism, Shanghai Traditional Chinese and Medicine Integrated Hospital, Shanghai, China. 3 Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China. 4 Department of Molecular Diagnostics & Endocrinology, The Core Laboratory in Medical Center of Clinical Research, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Frontiers in endocrinology 2023

关键词: Hashimoto autoimmune thyroiditis;SERPINA1;gene set enrichment analyses (GSEA);papillary thyroid cancer;weighted gene co- expression network analyses (WGCNA).

摘要: Background: Hashimoto's thyroiditis (HT) is an autoimmune thyroid disease. Papillary thyroid carcinoma (PTC) is the most common endocrine cancer. In r ...

作者: Ye Yang;Jun Liu;Xiaoqin Shi;Min Wang (Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Cancer Control 2023

摘要: Background Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma, and Hashimoto’s thyroiditis (HT) has been postulated to ...

作者: Hao Wu12;Yicheng Lu2;Zhenzhen Duan2;Jingni Wu2;Minghui Lin2;Yangjun Wu3;Siyang Han4;Tongqi Li4;Yuqi Fan5;Xiaoyuan Hu6;Hongyan Xiao7;Jiaxuan Feng8;Zhiqian Lu1CA1;Deping Kong2CA2;null;Shengli Li2CA31Department of Cardiovascular Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;2Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;3Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Shanghai, China;4Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;5North Cross School Shanghai, Shanghai, China;6H. Milton Stewart School of Industrial and Systems Engineering, College of Engineering, Geogia Institute of Technology, Atlanta, GA, USA;7Department of Cardiac Surgery, Wuhan Asia Heart Hospital, Wuhan University of Science and Technology, Wuhan, China;8Department of Vascular Surgery and Intervention Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Communications Biology 2023

摘要: Vascular smooth muscle cells (VSMCs) are the major contributor to vascular repair and remodeling, which showed high level of phenotypic plasticity. Ab ...

作者: Yingting Zhang1;Xidai Long2;Xin Ruan1;Qian Wei1;Lin Zhang3;Lulu Wo1;Dongdong Huang1;Longshuai Lin4;Difei Wang1;Li Xia5;Qinghua Zhao4;Junling Liu3;Qian Zhao1CA1;null;Ming He1CA21Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China;3Department of Biochemistry and Molecular Cell Biology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China;4Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China;5Department of Core Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Cell Discovery 2023

作者: Yuanyuan Liu1;Xing Wang23;Yuying Liu1;Jianqiang Yang4;Wei Mao1;Chen Feng1;Xiaoliang Wu5;Xinwei Chen1CA1;Lixiao Chen1CA2;null;Pin Dong1CA31Department of Otolaryngology: Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;2Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330046, China;3Centre for Medical Research and Translation, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, China;4Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, GA, 30322, USA;5Department of Oncology, Shenzhen Hospital of Southern Medical University, Shenzhen, 510086, China)

出处: Cell Death & Disease 2023

摘要: N4-acetylcytidine (ac4C) is a post-transcriptional RNA modification that regulates in various important biological processes. However, its role in hum ...

作者: Kangli Ma;Shu Li;Sufang Wu;Jingfen Zhu;Yongbin Yang (Affiliations 1 Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China. 2 School of Public Health, Shanghai Jiao Tong University, Shanghai, People's Republic of China.)

出处: Tobacco induced diseases 2023

关键词: human papillomavirus;normal uterine cervix;persistent infection;smoking.

摘要: Introduction: Smoking has been proven to increase the risk of cervical cancer, but it is still controversial whether smoking reduces women's ability t ...

作者: Fei Shi;Changqing Yang;Qingxin Jiang;Weifang Zhu;Xun Xu;Xinjian Chen;Ying Fan (Affiliations 1 Electronics and Information Engineering, Soochow University, 1 Shizi Street, Suzhou, 215006, CHINA. 2 Soochow University, 1 Shizi Street, Suzhou, Jiangsu, 215006, CHINA. 3 Shanghai General Hospital, No. 100 Haining Road, Shanghai, 200080, CHINA.)

出处: Physics in medicine and biology 2023

关键词: Deep learning;Multi-class segmentation;OCT image;Retinal detachment;Retinoschisis.

摘要: Retinal detachment (RD) and retinoschisis (RS) are the main complications leading to vision loss in high myopia. Accurate segmentation of RD and RS, i ...

作者: Hanhao Dai  1, Jun Luo  2, Lili Deng  3, Chao Song  1, Zhibo Deng  1, Yijing Wu  1, Song Gu  4, Jie Xu  1   2 (Affiliations 1 Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350000, China. 2 Department of Orthopedics, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350000, China. 3 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China. 4 Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China.)

出处: Advanced healthcare materials 2023

关键词: Extracellular vesicle;MicroRNA;Myogenesis;Sarcopenia;Stemness.

摘要: Sarcopenia is a geriatric disease characterized by reduced muscle function and mass. The capacity to self-renew and myogenesis of satellite cells (SCs ...

作者: Yi Zheng1;Jing Chen1;Xin-Ran Song2;Mei-Qi Chang3;Wei Feng2;Hui Huang2;Cai-Xia Jia1;Li Ding4CA1;Yu Chen2CA2;Rong Wu1CA31Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China;2Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, PR China;3Central Laboratory of Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, PR China;4Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University Cancer Center, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Tongji University School of Medicine, Tongji University, Shanghai, 200070, PR China)

出处: Biomaterials 2023

关键词: Antitumor immunotherapy;Innate immunity;Manganese;Synergistic therapy;cGAS-STING pathway

摘要: As the clinical efficacy of immunotherapy for triple-negative breast cancer (TNBC) remains limited, exploring new immunotherapy approaches is still in ...

作者: Senmiao Zhu1,2,3,4;Lili Chen1,2,4;Min Wang1,2,3,4;Jing Zhang2;Gang Chen2;Yinghao Yao5;Shihan Song1,2;Tong Li2;Shenglan Xu2;Zhonghao Yu1,2;Bingyan Shen1,2;Duogang Xu6;Zai-Long Chi1,2CA1;Wencan Wu1,2,3CA21National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China;2State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China;3Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang 325000, China;4These authors contributed equally to this work.;5Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325027, China;6Department of General Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China)

出处: Journal of Controlled Release 2023

关键词: Schwann cells;Optic neuropathy;Small extracellular vesicles;Natural biomaterials;Retinal ganglion cells;CREB signaling pathway

摘要: Optic neuropathy is the leading cause of irreversible blindness and is characterized by progressive degeneration of retinal ganglion cells (RGCs). Sev ...

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