作者： Xianyu Fan;Ji Li;Shengyuan Wu;Jingjing Jiang;Jiajing Wang;Shuowen Wang;Yuefen Lou;Guorong Fan （Department of Clinical Pharmacy, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P. R. China;Fan and Li contributed equally to this work.;Department of Clinical Pharmacy, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P. R. China;School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, P. R. China;Fan and Li contributed equally to this work.;Laboratory of Drug Metabolism &Pharmacokinetics, School of Medicine, Tongji University, Shanghai, P. R. China;Department of Pharmacy, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, P. R. China;Shanghai Center for Drug Evaluation and Inspection, Shanghai, P. R. China;Department of Clinical Pharmacy, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P. R. China;Department of Pharmacy, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, P. R. China;Department of Clinical Pharmacy, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P. R. China;Laboratory of Drug Metabolism &Pharmacokinetics, School of Medicine, Tongji University, Shanghai, P. R. China;Shanghai Key Laboratory for Pharmaceutical Metabolite Research, Shanghai, P. R. China;Prof. Guorong Fan, Department of Clinical Pharmacy, Shanghai General Hospital, No. 100 Haining Road, Shanghai 200080, P.R. China.）

出处： Journal of Separation Science

关键词： 9‐hydroxyrisperidone;capillary zone electrophoresis;field‐amplified sample injection;pharmacokinetics;risperidone

摘要： This article describes a method for the simultaneous quantitation of risperidone and its major metabolite, 9‐hydroxyrisperidone, in beagle dog plasma ...

作者： Zhong Zheng;Zhixian Yao MD;Ke Wu MD;Junhua Zheng MD （Department of Evidence‐based Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China;Shanghai Medical Aid Team in Wuhan, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China;Department of Evidence‐based Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China;Shanghai Medical Aid Team in Wuhan, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China;Department of Evidence‐based Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China;Shanghai Medical Aid Team in Wuhan, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China;Department of Evidence‐based Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China;Shanghai Medical Aid Team in Wuhan, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China）

出处： Journal of Medical Virology

关键词： chest radiography;computed tomography;coronavirus disease 2019;coronavirus pneumonia;diagnosis;polymerase chain reaction

摘要： The rapid emergence of coronavirus disease 2019 (COVID‐19) has necessitated the implementation of diverse pandemic control strategies throughout the w ...

作者： Dong li Li;Lei Mao;Qing Gu;Fang Wei;Yuan-yuan Gong （Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 20080 ; National Clinical Research Center for Eye Diseases, Shanghai, China, 200080 ; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China, 200080 ; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China, 200080 ; Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China, 200080 Department of Ophthalmology, Huadong hospital Affiliated to Fudan University, 221 West YanAn Road, Shanghai, PR China, 200040 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 20080 ; National Clinical Research Center for Eye Diseases, Shanghai, China, 200080 ; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China, 200080 ; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China, 200080 ; Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China, 200080 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 20080 ; National Clinical Research Center for Eye Diseases, Shanghai, China, 200080 ; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China, 200080 ; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China, 200080 ; Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China, 200080 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 20080 ; National Clinical Research Center for Eye Diseases, Shanghai, China, 200080 ; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China, 200080 ; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China, 200080 ; Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China, 200080）

出处： Cutaneous and Ocular Toxicology

关键词： Autophagy status;Outer blood-retina barrier;Tight junction;Human retinal pigment epithelial cells;Quercetin

摘要： Age-related macular degeneration (AMD) is the primary cause of irreversible severe visual loss among the elderly globally. Oxidative stress acts as a ...

作者： Min Li;Yunjie Yu;Ying Yuan;Peng Wang;Xiaojun Hu;Chengcheng Zhu;Bilian Ke （Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai, China ;Department of Ophthalmology, Zhongshan Hospital affiliated with Fudan University , Shanghai, China. Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai, China ; Shanghai Key Laboratory of Fundus Disease , Shanghai, China; Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai, China ; Shanghai engineering center for visual science and photomedicine , Shanghai, China; Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai, China ; Shanghai engineering center for precise diagnosis and treatment of eye diseases , Shanghai, China; Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai, China ; National Clinical Research Center for Eye Diseases; Shanghai , China; Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai, China ; Shanghai Key Laboratory of Fundus Disease , Shanghai, China; Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai, China ; National Clinical Research Center for Eye Diseases; Shanghai , China;）

出处： Current Eye Research

关键词： Rete ridges;inflammatory cytokines;meibomian gland dysfunction;dry eye

摘要： Purpose To evaluate the morphology and function of rete ridges in eyelid margin and inflammatory cytokines in meibomian gland dysfunction (MGD) assoc ...

作者： Ruhong,Jiang ;Minglong,Chen ;Jie,Fan ;Fu,Yi ;Anli,Tang ;Xingpeng,Liu ;Wenqing,Zhu ;Shaowen,Liu ;Xiaobo,Huang ;Weizhu,Ju ;Xi,Zhang ;Jie,Li ;Jiangui,He ;Liang,Shi ;Genqing,Zhou ;Yuegang,Wang ;Chenyang,Jiang （Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Zhejiang, 310016, Hangzhou, People\'s Republic of China. \'(1)\' ; The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. [2] ; The First Peoples\' Hospital of Yunnan Province, Yunnan, China. [3] ; Xijing Hospital, Air Force Medical University, Xi\'an, China. [4] ; The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. [5] ; Beijing Chaoyang Hospital affiliated to Capital Medical University, Beijing, China. [6] ; Zhongshan Hospital, Fudan University, Shanghai, China. [7] ; Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. [8] ; Nanfang Hospital, Southern Medical University, Guangzhou, China. [9] ; Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, 3 East Qingchun Road, Zhejiang, 310016, Hangzhou, People\'s Republic of China. cyjiang@zju.edu.cn. [10]）

出处： Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

关键词： Ablation index;Atrial fibrillation;Catheter ablation;Contact force;Radiofrequency ablation

摘要： Pulmonary vein isolation (PVI) has become the cornerstone of atrial fibrillation (AF) ablation, but long-term success rates remains suboptimal, due in ...

作者： Yu-Lei Zhang;Jun-Fang Zhang;Xi-Xi Wang;Yan Wang;Craig S. Anderson;Yun-Cheng Wu （Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People\'s Republic of China. \'(1)\' ; The George Institute, UNSW, Sydney, Australia. [2] ; Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People\'s Republic of China. yunchw@medmail.com.cn. [3]）

出处： Journal of Neurology

关键词： Wake-up stroke;Magnetic resonance imaging;Computed tomography perfusion;Thrombolysis;Thrombectomy;PWI–DWI mismatch;DWI–FLAIR mismatch

摘要： Wake-up stroke (WUS) is a subgroup of ischemic stroke in which patients show no abnormality before sleep while wake up with neurological deficits. In ...

作者： Wei Wang;Jun Yao;Xiaohui Guo;Yushan Guo;Chaoli Yan;Kuanzhi Liu;Ying Zhang;Xiaoyue Wang;Hongmei Li;Zhongyuan Wen;Xinling Wang;Shuangqing Li;Xinhua Xiao;Weijuan Liu;Ziling Li;Lihui Zhang;Shiying Shao;Shandong Ye;Guijun Qin;Yiming Li;Feng Li;Xiaomei Zhang;Xuefeng Li;Yongde Peng;Hongyan Deng;Xiangjin Xu;Ligang Zhou;Yanli Huang;Mengya Cao;Xuefang Xia;Mingbiao Shi;Jing Dou;Jing Yuan （Peking University First Hospital, Beijing, China; Peking University First Hospital, Beijing, China; Peking University First Hospital, Beijing, China; Affiliated Hospital of Beihua University, Jilin, China; The Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia, China; The Third Hospital of Hebei Medical University, Hebei, China; The Third Affiliated Hospital of Guangzhou Medical University, Guangdong, China; The First People’s Hospital of Yueyang, Hunan, China; Emergency General Hospital, Beijing, China; Renmin Hospital of Wuhan University, Hubei, China; Xinjiang Uiger Municipal People’s Hospital, Xinjiang, China; West China Hospital, Sichuan University, Sichuan, China; Peking Union Medical College Hospital, Beijing, China; Chongqing Three Gorges Central Hospital, Chongqing, China; Inner Mongolia Baogang Hospital, Inner Mongolia, China; The second Hospital of Hebei Medical University, Hebei, China; Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China; Anhui Provincial Hospital, Anhui, China; The First Affiliated Hospital of Zhengzhou University, Henan, China; Huashan Hospital Affiliated to Fudan University, Shanghai, China; Jining First People’s Hospital, Shandong, China; The First Affiliated Hospital of Bengbu Medical College, Anhui, China; Shiyan Taihe Hospital, Hubei, China; Shanghai General Hospital, Shanghai, China; Wuhan Puai Hospital, Hubei, China; 900 Hospital of the Joint Logistics Support Force of Chinese PLA, Fujian, China; Shanghai Pudong Hospital, Shanghai, China; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Hebei, China CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Hebei, China CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Hebei, China CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Hebei, China CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Hebei, China CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Hebei, China）

出处： Current Medical Research and Opinion

关键词： DBPR108;monotherapy;type 2 diabetes mellitus;DPP-4 inhibitor

摘要： Objective: DBPR108, a novel dipeptidyl-peptidase-4 inhibitor, has shown great antihyperglycemic effect in animal models. This study was to evaluate th ...

作者： Guogang Xie;Fengming Ding;Lei Han;Dongning Yin;Hongzhou Lu;Min Zhang （Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China;Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China;Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China;Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China;Department of Clinical Laboratory, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;Min Zhang, Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, 100 Haining road, Hongkou District Shanghai, 200080 China.;Hongzhou Lu, Department of Clinical Laboratory, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jinshan District, Shanghai, 201508 China.;Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China;Min Zhang, Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, 100 Haining road, Hongkou District Shanghai, 200080 China.;Hongzhou Lu, Department of Clinical Laboratory, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jinshan District, Shanghai, 201508 China.）

出处： Allergy

关键词： COVID‐19;diagnosis;peripheral blood eosinophils;pneumonia;prognosis

摘要： Background Coronavirus disease 2019 (COVID‐19) emerged in Wuhan city and rapidly spread globally outside China. We aimed to investigate the role of p ...

作者： Huihao Chen, MD;Depeng Meng, MD;Zheng Xie, MD;Gang Yin, MD;Chunlin Hou, MD;Haodong Lin, MD, PhD （Department of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People\'s Republic of China Department of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People\'s Republic of China Department of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, People\'s Republic of China Department of Orthopedic Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People\'s Republic of China Department of Orthopedic Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People\'s Republic of China Department of Orthopedic Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People\'s Republic of China）

出处： Operative Neurosurgery

关键词： Femoral nerve;Nerve injury;Nerve transfer;Reconstruction;Sciatic nerve

摘要： BACKGROUND Femoral nerve injury causes knee dysfunction, and high femoral nerve injury is difficult to repair. OBJECTIVE To evaluate the anatomic f ...

作者： Congying,Xia ;Marleen,Vonder ;Gert Jan,Pelgrim ;Mieneke,Rook ;Xueqian,Xie ;Abdullah,Alsurayhi ;Peter M A,van Ooijen ;Jurjen N,van Bolhuis ;Matthijs,Oudkerk ;Monique,Dorrius ;Pim,van der Harst ;Rozemarijn,Vliegenthart （University of Groningen, University Medical Center Groningen, Department of Radiology, Groningen, the Netherlands. Electronic address: c.xia@umcg.nl. \'(1)\' ; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands. Electronic address: m.vonder@umcg.nl. [2] ; University of Groningen, University Medical Center Groningen, Department of Radiology, Groningen, the Netherlands. Electronic address: g.j.pelgrim@umcg.nl. [3] ; University of Groningen, University Medical Center Groningen, Department of Radiology, Groningen, the Netherlands; Department of Radiology, Martini Hospital Groningen, Groningen, the Netherlands. Electronic address: m.rook@umcg.nl. [4] ; Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: xiexueqian@hotmail.com. [5] ; University of Groningen, Faculty of Medical Sciences, Groningen, the Netherlands. Electronic address: a.a.alsurayhi@student.rug.nl. [6] ; University of Groningen, University Medical Center Groningen, Department of Radiation Therapy, Groningen, the Netherlands. Electronic address: p.m.a.van.ooijen@umcg.nl. [7] ; Lifelines Cohort Study, Groningen, the Netherlands. Electronic address: j.n.van.bolhuis@lifelines.nl. [8] ; University of Groningen, Faculty of Medical Sciences, Groningen, the Netherlands; Institute for Diagnostic Accuracy, Groningen, the Netherlands. Electronic address: m.oudkerk@rug.nl. [9] ; University of Groningen, University Medical Center Groningen, Department of Radiology, Groningen, the Netherlands; University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, the Netherlands. Electronic address: m.d.dorrius@umcg.nl. [10] ; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands. Electronic address: p.van.der.harst@umcg.nl. [11] ; University of Groningen, University Medical Center Groningen, Department of Radiology, Groningen, the Netherlands. Electronic address: r.vliegenthart@umcg.nl. [12]）

出处： Journal of cardiovascular computed tomography

关键词： Computed tomography;Coronary artery calcium score;Dual source;High pitch

摘要： To determine the effect of low-dose, high-pitch non-electrocardiographic (ECG)-triggered chest CT on coronary artery calcium (CAC) detection, quantifi ...