作者： Guangjian Fan  ¹, Bo Yu  ², Lei Tang  ³, Rongxuan Zhu  ¹, Jianhua Chen  ², Ying Zhu  ¹, He Huang  ⁴, Liying Zhou  ⁴, Jun Liu  ⁵, Wei Wang  ⁵, Zhonghua Tao  ², Fengchun Zhang  ³, Siwei Yu  ¹, Xiaoqing Lu  ⁶, Yuan Cao  ¹, Shaoqian Du  ¹, Huihui Li  ⁷, Junjian Li  ¹, Jian Zhang  ⁸, He Ren  ⁹, Olivier Gires  ¹⁰, Haikun Liu  ¹¹, Xin Wang  ¹², Jun Qin  ¹³, Hongxia Wang  ^{1   2} （Affiliations ¹ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ² Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. ³ Department of Oncology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215000, China. ⁴ Shanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200243, China. ⁵ Department of Breast-thyroid Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁶ Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, China. ⁷ Department of Breast Medical Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong Province 271016, China. ⁸ Key Laboratory of Cell Differentiation and Apoptosis, Ministry of Education, Department of Pathophysiology, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 342500, China. ⁹ Center for GI Cancer Diagnosis and Treatment, Tumor Immunology and Cytotherapy, Medical Research Center, Affiliated Hospital of Qingdao University, Qingdao 266000, China. ¹⁰ Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital, LMU, Munich 80336, Germany. ¹¹ Division of Molecular Neurogenetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. ¹² Department of Surgery, Chinese University of Hong Kong Prince of Wales Hospital, Shatin, Hong Kong SAR 999077, China. ¹³ CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.）

出处： Science translational medicine 2024

摘要： Cancer-associated fibroblasts (CAFs) are abundant stromal cells in the tumor microenvironment that promote cancer progression and relapse. However, th ...

作者： Deping Kong ^{#  1   2}, Jing Liu ^{#  1}, Junmi Lu ^{#  3}, Cheng Zeng ^{#  1}, Hao Chen  ¹, Zhenzhen Duan  ², Ke Yu  ⁴, Xialei Zheng  ¹, Pu Zou  ¹, Liufang Zhou  ^{1   5}, Yicheng Lv  ², Qingye Zeng  ², Lin Lu  ⁶, Jiang Li  ¹, Yuhu He  ¹ （Affiliations ¹ Department of Cardiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. (D.K., J. Liu, C.Z., H.C., X.Z., P.Z., L.Z., J. Li, Y.H.). ² Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. (D.K., Z.D., Y.L., Q.Z.). ³ Department of Pathology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. (J. Lu). ⁴ Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Guangdong, China (K.Y.). ⁵ Department of Cardiovascular Medicine, The Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi, China (L.Z.). ⁶ Department of Cardiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, China. (L.L.).）

出处： Arteriosclerosis, thrombosis, and vascular biology 2024

关键词： apoptosis;biomarkers;cell proliferation;hypoxia;myocytes, smooth muscle.

摘要： Background: Pulmonary hypertension (PH) is a progressive and life-threatening disease characterized by pulmonary vascular remodeling, which involves a ...

作者： Yun Xie¹;Hui Lv¹;Daonan Chen¹;Peijie Huang¹;Shaohong Wu¹;Hongchao Shi¹CA1;Qi Zhao¹CA2;Ruilan Wang¹CA3 （¹Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Journal of Intensive Medicine 2024

关键词： Thrombopoietin;Sepsis;Endothelial cells

摘要： Background To evaluate the effect of recombinant human thrombopoietin (rhTPO) on clinical prognosis by exploring changes in endothelial cell injury ma ...

作者： X G He  ¹ （Affiliation ¹ Shanghai Eye Disease Prevention and Treatment Center, Tongji University Affiliated Eye Hospital, Shanghai General Hospital of Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Diseases, Shanghai 201103, China.）

出处： [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2024

摘要： The International Myopia Institute introduced the concept of 'pre-myopia' in 2019, defining it as children with refractive error ≤+0.75 D and >-0.50 D ...

作者： Zhonglin Zhu^1,2,3;Minghan Li^1,2,3;Junyong Weng^1,2,3;Shanbao Li^4,3;Tianan Guo^1,2;Yang Guo^1,2;Ye Xu^1,2CA1 （¹Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, PR China;²Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China;³Zhonglin Zhu, Minghan Li, Junyong Weng and Shanbao Li contributed equally to this work.;⁴Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China）

出处： Cancer Letters 2024

关键词： Colorectal cancer;5-Fluorouracil;Resistance;GAS6-AS1;PCBP1

摘要： 5-Fluorouracil (5-FU) resistance has always been a formidable obstacle in the adjuvant treatment of advanced colorectal cancer (CRC). In recent years, ...

作者： Rui Chen^1,2,3;Xiaojie Yu^4,5,3;Weiheng Wang²;Liang Zhu⁵;Ronghua Yu¹;Guoke Tang^1,5CA1;Xing Wang⁴CA2;Jiangming Yu¹CA3 （¹Department of Orthopedics, Tongren Hospital, Shanghai Jiaotong University, Shanghai 200336, China;²Department of Orthopedics, Second Affiliated Hospital of Naval Medical University, Shanghai 20003, China;³These authors contributed equally to this work.;⁴Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;⁵Department of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 200080, China）

出处： Polymer Testing 2024

关键词： Hydrogel scaffold;Schiff base;Tetra-PEG;Chitosan;Cartilage regeneration

摘要： The development of advanced hydrogel scaffolds with good biocompatibility, mechanical strength and bioactive property is highly desirable in cell grow ...

作者： Su Feng  ¹, Ting Zhang  ^{2   3   4}, Zhengxiao He  ¹, Wenchang Zhang  ¹, Yingying Chen  ¹, Chunmei Yue  ⁵, Naihe Jing  ⁶ （Affiliations ¹ Guangzhou National Laboratory, Guangzhou, 510005, China. ² Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ National Clinical Research Center for Eye Disease, Shanghai, 200080, China. ⁴ Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, 200080, China. ⁵ Suzhou Yuanzhan Biotechs, Suzhou, 215000, China. ⁶ Guangzhou National Laboratory, Guangzhou, 510005, China. njing@sibcb.ac.cn.）

出处： Cell regeneration (London, England) 2024

关键词： Cell transplantation;Human induced neural stem/progenitor cells (iNPCs);Immune response;Non-human primate brain;Xenograft.

摘要： Continuous immunosuppression has been widely used in xenografts into non-human primate brains. However, how immune responses change after transplantat ...

作者： Chen Jin  ^{1   2}, Kaiwei Wang  ¹, Yilong Ren  ^{1   3}, Yi Li  ¹, Zhanwei Wang  ¹, Liming Cheng  ¹, Ning Xie  ¹ （Affiliations ¹ Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji Hospital School of Medicine Tongji University Shanghai China. ² Department of Orthopedics Tongren Hospital Shanghai Jiaotong University School of Medicine Shanghai China. ³ Department of Orthopedics Shanghai General Hospital Shanghai Jiaotong University School of Medicine Shanghai China.）

出处： MedComm 2024

关键词： Spinal cord injury;decompression;durotomy;functional recovery;secondary injuries.

摘要： Currently, there is a lack of effective treatments for spinal cord injury (SCI), a debilitating medical condition associated with enduring paralysis a ...

作者： Lubing Cai^1,2;Jiale Tan^1,2;Xinyi Chen¹;Fuchao Wang³;Xingyu Zhang¹;Jiwu Chen¹;Cong Liu³CA1;Yaying Sun¹CA2 （¹Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China;²These authors contributed equally to this work.;³School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China）

出处： Ecotoxicology and Environmental Safety 2024

关键词： Sarcopenia;Air pollution;UK Biobank;Physical activity

摘要： Background Sarcopenia is characterized by decreased muscle mass and strength, posing threat to quality of life. Air pollutants are increasingly recogn ...

作者： Jiyu Zhang¹;Tao Huang²;Qiao Sun³;Jian Zhang*¹ （¹Department of Ophthalmology, Shanghai General Hospital, Shanghai, China National Clinical Research Center for Eye Diseases, Shanghai, China Shanghai Clinical Research Center for Eye Diseases, Shanghai, China Shanghai Key Clinical Specialty, Shanghai, China Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China;²Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China;³Department of Ophthalmology, Shanghai Aier Eye Hospital, Shanghai Aier Eye Institute, Shanghai, China）

出处： Current Bioinformatics 2024

关键词： Pathological myopia;high myopia;degenerative myopia;random walk with restart algorithm;protein-protein interaction network;screening test

摘要： Background: Pathological myopia, a severe variant of myopia, extends beyond the typical refractive error associated with nearsightedness. While the co ...