作者： Yan Hu  ¹, Xiaoqun Li  ², Xiao Chen  ¹, Sicheng Wang  ³, Liehu Cao  ⁴, Hao Zhang  ¹, Yunfei Zhang  ⁵, Zhiwei Wang  ⁶, Baoqing Yu  ⁷, Peijian Tong  ⁸, Qiang Zhou  ⁹, Feng Niu  ¹⁰, Weiguo Yang  ¹¹, Wencai Zhang  ¹², Shijie Chen  ¹³, Qiang Yang  ¹⁴, Tao Shen  ¹⁵, Peng Zhang  ¹⁶, Yong Zhang  ⁵, Jun Miao  ¹⁴, Haodong Lin  ¹⁷, Jinwu Wang  ¹⁸, Lei Wang  ¹⁹, Xin Ma  ²⁰, Hongjian Liu  ²¹, Ilia Stambler  ^{22   23}, Long Bai  ²⁴, Han Liu  ²⁴, Yingying Jing  ²⁴, Guohui Liu  ²⁵, Xinglong Wang  ²⁶, Dongliang Wang  ¹, Zhongmin Shi  ²⁰, Robert Chunhua Zhao  ^{23   27}, Jiacan Su  ^{1   24} （Affiliations ¹ Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ² First Affiliated Hospital of Naval Medical University, Shanghai, China. ³ Shanghai Zhongye Hospital, Shanghai, China. ⁴ Luodian Hospital, Baoshan District, Shanghai, China. ⁵ Tangdu Hospital Air Force Medical University, Xi'an, China. ⁶ Eastern Hepatobiliary Surgery Hospital, Shanghai, China. ⁷ Shanghai Pudong New Area People's Hospital, Shanghai, China. ⁸ Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou, China. ⁹ Third Affiliated Hospital of Chongqing Medical University, Chongqing, China. ¹⁰ First Bethune Hospital of Jilin University, Changchun, China. ¹¹ HKU Li Ka Shing Faculty of Medicine, Hongkong, China. ¹² First Affiliated Hospital of Jinan University, Guangzhou, China. ¹³ Third Xiangya Hospital of Central South University, Changsha, China. ¹⁴ Tianjin Hospital, Tianjin, China. ¹⁵ Shengjing Hospital of Chinese Medical University, Shenyang, China. ¹⁶ Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. ¹⁷ Shanghai General Hospital, Shanghai, China. ¹⁸ Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁹ Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China. ²⁰ Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China. ²¹ First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. ²² Department of Science, Technology and Society, Bar Ilan University, Ramat Gan, Israel. ²³ International Society on Aging and Disease, Bryan, TX, USA. ²⁴ Institute of Translational Medicine, Shanghai University, Shanghai, China. ²⁵ Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ²⁶ Department of Pharmacology & Toxicology, University of Arizona, Tucson, USA. ²⁷ Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.）

出处： Aging and disease 2024

摘要： Osteoporotic fractures are the most severe complications of osteoporosis, characterized by poor bone quality, difficult realignment and fixation, slow ...

作者： Yun Zhang  ¹, Ge Tian  ¹, Xueni Sun  ¹, Xiaoli Yang  ¹, Yi Zhang  ¹, Wenqing Tan  ¹, Liangwei Duan  ², Shunxiang Gao  ³, Junping Yu  ^{4   5} （Affiliations ¹ Laboratory of Infection and Immunology, School of Medical Technology, Xinxiang Medical University, Xinxiang, 453003, People's Republic of China. ² Laboratory of Infection and Immunology, School of Medical Technology, Xinxiang Medical University, Xinxiang, 453003, People's Republic of China. duanliangwei@xxmu.edu.cn. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, People's Republic of China. shunxianggao@163.com. ⁴ Laboratory of Infection and Immunology, School of Medical Technology, Xinxiang Medical University, Xinxiang, 453003, People's Republic of China. yujp@wh.iov.cn. ⁵ CAS Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, People's Republic of China. yujp@wh.iov.cn.）

出处： Mikrochimica acta 2024

关键词： S. aureus;Chicken IgY;Specificity;Wheat germ agglutinin.

摘要： A novel colorimetric platform was designed for the determination of S. aureus by utilizing a dual-recognition strategy, where wheat germ agglutinin (W ...

作者： Jie Mei  ^{1   2}, Yun Cai  ³, Rui Xu  ^{1   2}, Qing Li  ⁴, Jiahui Chu  ^{1   2}, Zhiwen Luo  ⁵, Yaying Sun  ⁶, Yuxin Shi  ⁷, Junying Xu  ⁷, Di Li  ⁸, Shuai Liang  ⁷, Ying Jiang  ⁹, Jiayu Liu  ⁹, Zhiwen Qian  ³, Jiaofeng Zhou  ¹⁰, Mengyun Wan  ¹⁰, Yunlong Yang  ¹¹, Yichao Zhu  ¹⁰, Yan Zhang  ^{3   9}, Yongmei Yin  ^{1   12} （Affiliations ¹ Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, P. R. China. ² The First Clinical Medicine College, Nanjing Medical University, Nanjing, Jiangsu, P. R. China. ³ Departments of Gynecology, Wuxi Maternal and Child Health Care Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, P. R. China. ⁴ Departments of Oncology, Xuzhou Central Hospital, The Xuzhou School of Clinical Medicine of Nanjing Medical University, Xuzhou, Jiangsu, P. R. China. ⁵ Department of Sports Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai, P. R. China. ⁶ Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China. ⁷ Departments of Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu, P. R. China. ⁸ Shanghai Outdo Biotech Co., Ltd., National Engineering Center for Biochip, Shanghai, P. R. China. ⁹ Departments of Gynecology, Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Wuxi, Jiangsu, P. R. China. ¹⁰ Department of Physiology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu, P. R. China. ¹¹ Department of Cellular and Genetic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, P. R. China. ¹² Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.）

出处： Cancer communications (London, England) 2024

关键词： collagen deposition;immune infiltration;immunotherapy;pan‐cancer;tumor microenvironment.

摘要： Background: Immune checkpoint blockade (ICB) has revolutionized the treatment of various cancer types. Despite significant preclinical advancements in ...

作者： Guantong Sun¹;Xiaodong Li¹;Pengcheng Liu²;Yao Wang¹;Cheng Yang¹;Shuhong Zhang¹;Lei Wang¹;Xiaoqing Wang¹ （¹Department of Orthopedics, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China）

出处： Frontiers in Pharmacology 2024

关键词： PPARδ;osteoarthritis;autophagy;apoptosis;AKT/mTOR signaling

摘要： Osteoarthritis (OA) is the most prevalent degenerative joint disease, and PPARs are involved in its pathogenesis; however, the specific mechanisms by ...

作者： Chao Li¹;Jiajun Qin¹;Fei Xue¹;Zhaoli Shen¹;Qi Lin¹;Yajun Xue²;Xianzhen Chen¹ （¹Department of Neurosurgery, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China;²Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Frontiers in Neurology 2024

关键词： atypical meningioma;gross total resection;radiation therapy;overall survival;age

摘要： BackgroundThis study aimed to investigate the effects of adjuvant beam radiation therapy (ABRT) on overall survival (OS) in patients with primary sing ...

作者： Yang Xue  ¹, Pengqi Yin  ², Hongping Chen  ¹, Guozhong Li  ³, Di Zhong  ¹ （Affiliations ¹ Department of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin, China. ² Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Neurology, Heilongjiang Provincial Hospital, Harbin, China.）

出处： Autoimmunity 2024

关键词： IFN- therapy;Multiple sclerosis;drug responsiveness;prognostic model construction;survival analysis.

摘要： Interferon-beta (IFN-β) is one of the classical drugs for immunomodulatory therapy in relapsing-remitting multiple sclerosis (RRMS) patients, but the ...

作者： Chang Gao¹;Nan Sun¹;Jinying Xie²;Jiehao Li²;Lin Tao¹;Lijuan Guo¹;Lan Shi³;Xiaojin He⁴;Xiaoting Shen⁵;Hua Wang¹;Pan Yang⁶;Adrian Covaci⁷;Yichao Huang⁸ （¹Department of Toxicology, School of Public Health, Center for Big Data and Population Health of IHM, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China;²Department of Public Health and Preventive Medicine, China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou, China;³NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui Province, China;⁴Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui Province, China;⁵Reproductive Medicine Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China;⁶Department of Public Health and Preventive Medicine, China Greater Bay Area Research Center of Environmental Health, School of Medicine, Jinan University, Guangzhou, China;Corresponding authors at: Clinical Research Center, Suzhou Hospital of Anhui Medical University, Anhui Medical University, 616 Bianyang 3rd Rd, Suzhou 234099, China (Y. Huang). Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, 601 Huangpu W Ave, Guangzhou, 510632, China (P. Yang).;⁷Toxicological Center, University of Antwerp, Wilrijk, Belgium;⁸Clinical Research Center, Suzhou Hospital of Anhui Medical University, Anhui Medical University, Suzhou, China;Department of Toxicology, School of Public Health, Center for Big Data and Population Health of IHM, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, China;Corresponding authors at: Clinical Research Center, Suzhou Hospital of Anhui Medical University, Anhui Medical University, 616 Bianyang 3rd Rd, Suzhou 234099, China (Y. Huang). Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, 601 Huangpu W Ave, Guangzhou, 510632, China (P. Yang).）

出处： Environment International 2024

关键词： Endocrine disrupting chemicals;Semen quality;Mixture effect;Seminal plasma;Omega-3 polyunsaturated fatty acids

摘要： Isolated effects of single endocrine-disrupting chemicals (EDCs) on male reproductive health have been studied extensively, but their mixture effect r ...

作者： Ming Tong  ¹, Yun Bai  ², Jiao Lyu  ³, Ling Ren  ¹, Linyu Zhang  ^{4   5}, Mudi Yao  ¹, Xiaoyan Han  ¹, Xiumiao Li  ^{4   5}, Dan Li  ¹, Pei-Quan Zhao  ³, Qin Jiang  ^{4   5}, Biao Yan  ^{1   6} （Affiliations ¹ Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China. ² College of Information Science, Shanghai Ocean University, Shanghai, China. ³ Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. ⁴ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, China. ⁵ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Clinical and translational medicine 2024

作者： Ming Tong  ¹, Yun Bai  ², Xiaoyan Han  ¹, Lingjie Kong  ¹, Ling Ren  ¹, Linyu Zhang  ³, Xiumiao Li  ⁴, Jin Yao  ⁵, Yan Biao  ⁶ （Affiliations ¹ Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, 200031, China. ² College of Information Science, Shanghai Ocean University, Shanghai, 201306, China. ³ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China; The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. ⁴ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. ⁵ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China; The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. Electronic address: jinyao1972@126.com. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: biao.yan@fdeent.org.）

出处： Experimental eye research 2024

关键词： Age-related macular degeneration;Choroidal neovascularization;Endothelial heterogeneity;Single-cell sequencing.

摘要： Choroidal neovascularization (CNV) is a hallmark of neovascular age-related macular degeneration (nAMD) and a major contributor to vision loss in nAMD ...

作者： Xiaoye Shi ^{#  1   2}, Gengwen Deng ^{#  1   3}, Haiteng Wen  ^{1   2}, Anqi Lin  ¹, Haitao Wang  ⁴, Lingxuan Zhu  ^{1   5}, Weiming Mou  ^{1   6}, Zaoqu Liu  ^{7   8}, Xiaohua Li  ⁹, Jian Zhang  ¹, Quan Cheng  ^{10   11}, Peng Luo  ¹ （Affiliations ¹ Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. ² The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. ³ The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. ⁴ Thoracic Surgery Branch, Centre for Cancer Research, National Institutes of Health, Bethesda, Maryland, USA. ⁵ Department of Aetiology and Carcinogenesis, National Cancer Centre, National Clinical Research Centre for Cancer, Cancer Hospital, Changping Laboratory, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ⁶ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ Key Laboratory of Proteomics, Beijing Proteome Research Centre, National Centre for Protein Sciences, Beijing Institute of Lifeomics, Beijing, China. ⁸ Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Pathophysiology, Peking Union Medical College, Beijing, China. ⁹ Department of Respiratory and Critical Care Medicine, Sixth People's Hospital of Chengdu, Chengdu, Sichuan, China. ¹⁰ Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. ¹¹ National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China.）

出处： Journal of global health 2024

摘要： Background: This study was designed to evaluate the effects of body mass index (BMI) and weight change on the risk of developing cancer overall and ca ...