作者： Ying Cao  ¹, Ruolan Qian  ¹, Ruilian Yao  ², Quan Zheng  ³, Chen Yang  ¹, Xupeng Yang  ⁴, Shuyi Ji  ⁴, Linmen Zhang  ¹, Shujie Zhan  ¹, Yiping Wang  ⁵, Tianshi Wang  ⁶, Hui Wang  ¹, Chun-Ming Wong  ⁷, Shengxian Yuan  ⁸, Christopher Heeschen  ³, Qiang Gao  ⁴, René Bernards  ⁹, Wenxin Qin  ¹⁰, Cun Wang  ¹¹ （Affiliations ¹ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. ³ Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Liver Surgery and Transplantation, Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China. ⁵ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Nephrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ State Key Laboratory for Liver Research and Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China. ⁸ The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China. ⁹ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: r.bernards@nki.nl. ¹⁰ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: wxqin@sjtu.edu.cn. ¹¹ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: cwang@shsci.org.）

出处： Developmental cell 2025

关键词： DYRK1A;IACS-010759;TGF-β signaling;hepatocellular carcinoma;oxidative phosphorylation.

摘要： Intervening in mitochondrial oxidative phosphorylation (OXPHOS) has emerged as a potential therapeutic strategy for certain types of cancers. Employin ...

作者： Jia Li  ¹, Lei Chen  ¹, Ronghui Wang  ², Jiang Zhu  ^{3   4}, Ao Li  ⁵, Jianchun Li  ⁶, Zhaojun Li  ⁷, Wen Luo  ⁸, Wenkun Bai  ¹, Tao Ying  ¹, Cong Wei  ⁹, Di Sun  ¹⁰, Yuanyi Zheng  ¹¹ （Affiliations ¹ Department of Ultrasound in Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. ² Department of Ultrasound, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ³ Department of Ultrasound, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. ⁴ Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China. ⁵ Department of Ultrasound, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. ⁶ Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, 310014, China. ⁷ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. ⁸ Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. ⁹ Department of Ultrasound in Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. weicong1985@163.com. ¹⁰ Department of Ultrasound in Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. Sundy316@163.com. ¹¹ Department of Ultrasound in Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. zhengyuanyi@163.com.）

出处： BMC medical imaging 2025

关键词： Breast tumors;Histologic biomarkers;Microvasculature;Ultrasound localization microscopy.

摘要： Background: Benign and malignant breast tumors differ in their microvasculature morphology and distribution. Histologic biomarkers of malignant breast ...

作者： Ming-Wang Wang  ¹, Lun-Gen Lu  ¹ （Affiliation ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Journal of clinical and translational hepatology 2025

关键词： Clinical trial;Fibrosis;Glucagon-like peptide-1 receptor agonist;Metabolic dysfunction-associated steatohepatitis;Metabolic dysfunction-associated steatotic liver disease;Treatment.

摘要： Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently a pressing public health issue associated with adverse outcomes such as ...

作者： Jiandong Zhou  ¹, Yunshan Guo  ¹, Xuan Liu  ¹, Weijie Yuan  ¹ （Affiliation ¹ Department of Nephrology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.）

出处： Adipocyte 2025

关键词： Secretory proteins;adipose tissue;bioinformatics;epigenetics;metabolic syndrome.

摘要： The objective of this study was to identify key secretory protein-encoding differentially expressed genes (SP-DEGs) in adipose tissue in female metabo ...

作者： Wei Chen  ¹, Yuanjun Tang  ², Yachen Si  ¹, Boxiang Tu  ³, Fuchuan Xiao  ⁴, Xiaolu Bian  ¹, Ying Xu  ¹, Yingyi Qin  ³ （Affiliations ¹ Department of Nephrology, Shanghai Changhai Hospital, Shanghai 200433, China. ² Department of Clinical Pharmacy, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200240, China. ³ Department of Military Health Statistics, Naval Medical University, Shanghai 200433, China. ⁴ Navy No. 929 Hospital, Shanghai 200433, China.）

出处： Journal of translational internal medicine 2025

关键词： all-cause mortality;chronic kidney disease;life’s essential 8.

摘要： Background and objectives: The association between chronic kidney disease (CKD) and cardiovascular disease has been previously evaluated. This study a ...

作者： Liang Wang  ¹, Yuanqi Wang  ², Tiantian Jiao  ², Linghao Xu  ¹, Endong Ji  ³, Sakibur Rahman Tapu  ², Yehong Liu  ¹, Jiming Li  ^{4   5} （Affiliations ¹ Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. ² School of Medicine, Tongji University, Shanghai, China. ³ Department of Emergency and Critical Care, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. ljm13303818674@126.com. ⁵ Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. ljm13303818674@126.com.）

出处： Journal of cardiothoracic surgery 2025

关键词： Arterial stiffness;Continuous positive airway pressure;Coronary heart disease;Inflammatory factors;Obstructive sleep apnea.

摘要： Background: Continuous Positive Airway Pressure (CPAP) treatment brings more benefits than risks to most coronary heart disease (CHD) patients with ob ...

作者： Hui Cheng  ¹, Li Chen  ¹, Chongmei Huang  ² （Affiliations ¹ Department of Hematology, First Affiliated Hospital, Naval Medical University, Shanghai 200433, P.R. China. ² Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China.）

出处： Oncology letters 2025

关键词： acute myeloid leukemia;function;inhibitors;signal transducer and activator of transcription 3;targeted therapy.

摘要： Signal transducer and activator of transcription 3 (STAT3), a crucial transcription factor, exerts a notable influence by hyperactivating or acquiring ...

作者： Ruilong Wang  ¹, Yue Yin  ², Yongxing Zhang  ³, Yi Liu  ⁴, Xinyu Wang  ⁵, Chencong Lv  ⁵, Xiao Bin  ⁴, Yanhai Xi  ⁴, Weiheng Wang  ⁴, Guoying Deng  ⁶, Songkai Li  ⁷, Chengwei Yang  ⁷ （Affiliations ¹ Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China. ² Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R.China. ³ Department of Orthopedics, Second Affiliated Hospital of Zhejiang University, Hangzhou, P.R.China. ⁴ Department of Orthopaedics, Second Affiliated Hospital of Naval Medical University, Shanghai, P.R.China. ⁵ Shanghai Jiaotong University School of Medicine, Shanghai, P.R.China. ⁶ Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R.China. ⁷ Department of Spine Surgery, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, P.R. China.）

出处： International journal of environmental health research 2025

关键词： Neck and shoulder pain;college students;spinal curvature;use of digital products.

摘要： Neck and shoulder pain (NSP) is a common issue among college students, yet no studies have linked digital device usage to NSP prevalence in China. Thi ...

作者： Ying Yuan  ^{1   2   3}, Fang Li  ⁴, Weijung Ten  ^{1   5}, Chengcheng Jin  ¹, Yue Wu  ⁶, Yuying Liu  ⁶, Bilian Ke  ⁷ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² National Clinical Research Center for Eye Diseases, Shanghai, China. ³ Shanghai Key Laboratory of Fundus Disease, Shanghai, China. ⁴ Department of Ultrasonography, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China. ⁶ Department of Ophthalmology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200001, China. ⁷ Department of Ophthalmology, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, 160 Pujian Road, Shanghai, 200001, China. kebilian@126.com.）

出处： Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2025

关键词： Choroidal thickness;Choroidal vascularity;High myopia;Peripapillary retinal nerve fiber layer;Scleral elastic modulus;Shear wave elastography.

摘要： Purpose: To evaluate the posterior scleral stiffness of different regions in high myopic eyes and to explore its associations with macular choroidal a ...

作者： Yi Lu  ¹, Jiamin Xie  ¹, Lele Cheng  ², Qingdong Fu  ², Miao Wu  ³, Ji Jin  ⁴, Xun Xu  ⁵ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai, China; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China, Shanghai, China. ² Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China, Shanghai, China. ³ Hangzhou Chaoju Eye Hospital, Hangzhou, Zhejiang Province, China. ⁴ Hangzhou Chaoju Eye Hospital, Hangzhou, Zhejiang Province, China. Electronic address: jinji2@sina.com.cn. ⁵ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai, China; Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China, Shanghai, China. Electronic address: drxuxun@sjtu.edu.cn.）

出处： Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2025

关键词： axial length;myopia control;myopia progression;recombinant human growth hormone.

摘要： Purpose: To explore the correlation between recombinant human growth hormone (rhGH) therapy and myopia progression, and to optimize the myopia control ...