作者： Yanting Che  ^{1   2   3}, Jingzhi Yang  ², Fen Tang  ³, Ziheng Wei  ⁴, Yufan Chao  ³, Na Li  ³, Henghui Li  ², Si Wu  ⁵, Xin Dong  ^{2   3} （Affiliations 1 College of Sciences, Shanghai University, Shanghai 200444, China. 2 Institute of Translational Medicine, Shanghai University, Shanghai 200444, China. 3 School of Medicine, Shanghai University, Shanghai 200444, China. 4 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. 5 Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.）

出处： International journal of molecular sciences 2022 Vol.23 No.4 P2020

关键词： 20S-hydroxycholesterol (20S-HC);22S-hydroxycholesterol (22S-HC);27-hydroxycholesterol (27-HC);cholesterol oxidation products (COPs);osteoporosis (OP).

摘要： Osteoporosis (OP) is a systemic bone disease characterized by decreased bone strength, microarchitectural changes in bone tissues, and increased risk ...

作者： Zhang, Tianliang¹;Dong, Xiao^1,2;Zhou, Yang³;Liu, Muhan³;Hang, Junjie³;Wu, Lixia⁴ （1 School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing, China 2 Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 3 Changzhou No. 2 People\'s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu, China 4 Department of Oncology, Shanghai JingAn District ZhaBei Central Hospital, Shanghai, China）

出处： Cancer Biomarkers 2022 Vol.32 No.4 P541-550

关键词： Liver metastases;metastatic patterns;pancreatic cancer;radiomics nomogram;texture features

摘要： BACKGROUND: Patients with advanced pancreatic cancer (APC) and liver metastases have much poorer prognoses than patients with other metastatic pattern ...

作者： Lizhi Zhang  ^{1   2}, Jinwei He  ³, Xiang Sun  ⁴, Dongyue Pang  ¹, Jingjing Hu  ¹, Bo Feng  ² （Affiliations 1 Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. 2 Department of Endocrinology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People\'s Hospital, Shanghai, China. 4 Shanghai Institute of Technology, Shanghai, China.）

出处： Endocrine connections 2022 Vol.11 No.2

关键词： bone mineral density;glucose-dependent insulinotropic peptide;haplotype;osteoporosis;polymorphism;single-nucleotide polymorphism.

摘要： We demonstrated previously that there is a correlation between glucagon-like peptide-1 (GLP-1) single-nucleotide polymorphism (SNP) and bone mineral d ...

作者： Yiwen Zhang  ¹, Haoyu You  ¹, Yaoben Wang  ², Qinjun Chen  ¹, Qin Guo  ¹, Yongchao Chu  ¹, Chao Li  ¹, Wenxi Zhou  ¹, Hongyi Chen  ¹, Peixin Liu  ¹, Yu Wang  ¹, Zhenhao Zhao  ¹, Zheng Zhou  ¹, Yifan Luo  ¹, Xuwen Li  ¹, Tongyu Zhang  ¹, Haolin Song  ¹, Chufeng Li  ¹, Boyu Su  ¹, Tao Sun  ¹, Yunke Bi  ³, Lin Yu  ², Chen Jiang  ¹ （Affiliations 1 Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, China. 2 State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, 200438, China. 3 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201203, China.）

出处： Advanced healthcare materials 2022 Vol.11 No.3 Pe2101578

关键词： drug delivery;glioblastoma;injectable hydrogels;microenvironments;post-operative therapy.

摘要： The rapid postoperative recurrence and short survival time of glioblastoma (GBM) patients necessitate immediate and effective postoperative treatment. ...

作者： Yuhong Chen  ^{1   2}, Xinyue Zhu  ^{1   2}, Fuxiang Ye  ^{1   2}, Hong Wang  ^{1   2}, Xiaoling Wan  ^{1   2   3}, Ting Zhang  ^{1   2   3}, Yuwei Wang  ^{1   2}, Yimin Wang  ^{1   2}, Xiaohuan Zhao  ^{1   2}, Xinyue Bai  ^{1   2}, Yushu Xiao  ^{1   2}, Xiaodong Sun  ^{1   2   3   4} （Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. 2 National Clinical Research Center for Eye Diseases, Shanghai, China. 3 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. 4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China.）

出处： Translational vision science & technology 2022 Vol.11 No.1 P12

摘要： Purpose: This study aimed to establish a novel choroidal neovascularization (CNV) mouse model through subretinally injecting malondialdehyde (MDA)-mod ...

作者： Min Zhou  ¹, Wan Zhang  ², Yucheng Zhang  ³, Tianchen Xie  ¹, Jieqi Mao  ⁴, Zhenyu Shi  ⁵ （Affiliations 1 Department of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai, China. 2 Department of Vascular Surgery, Huadong Hospital Affiliated to Fudan University, Shanghai, China. 3 Department of Vascular Surgery, Wusong Branch, Zhongshan Hospital, Fudan University, Shanghai, China. 4 Department of Vascular Surgery, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. 5 Department of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai, China shizhenyumax@163.com.）

出处： BMJ open 2022 Vol.12 No.2 Pe056826

关键词： anticoagulation;thromboembolism;vascular surgery.

摘要： Introduction: The efficacy and safety of anticoagulant treatment is not established for patients with acute symptomatic isolated distal deep vein thro ...

作者： Di Mu¹;Yan-Gang Sun^2,3CA1 （1 Department of Anesthesiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; 2 Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Sciences, Shanghai, China; 3 Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China）

出处： Journal of Investigative Dermatology 2022 Vol.142 No.1 P23-30

摘要： Itch is an unpleasant somatic sensation with the desire to scratch, and it consists of sensory, affective, and motivational components. Acute itch ser ...

作者： Ying Zheng  ^{1   2}, Maria Casagrande  ³, Spyridon Dimopoulos  ⁴, Karl-Ulrich Bartz-Schmidt  ⁴, Martin Stephan Spitzer  ³, Christos Skevas  ³ （Affiliations 1 Department of Ophthalmology, University Medical Center Hamburg-Eppen- dorf, Hamburg, Germany. anniaannia@126.com. 2 Department of Ophthalmology, Shanghai General Hospital Afliated to Shanghai Jiaotong University, 100 Haining Road, Shang- hai, 200080, China. anniaannia@126.com. 3 Department of Ophthalmology, University Medical Center Hamburg-Eppen- dorf, Hamburg, Germany. 4 Department of Ophthalmology, Eberhard Karls University Medical Center, Tübingen, Germany.）

出处： BMC ophthalmology 2022 Vol.22 No.1 P61

作者： Yimin Wang  ^{1   2   3   4}, Minyue Xie  ⁵, Min Zhang  ^{1   2   3   4}, Xiaohuan Zhao  ^{1   2   3   4}, Xinyue Zhu  ^{1   2   3   4}, Yuwei Wang  ^{1   2   3   4}, Yuhong Chen  ^{1   2   3   4}, Jieqiong Chen  ^{1   2   3   4}, Xiaodong Sun  ^{1   2   3   4} （Affiliations 1 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 National Clinical Research Center for Eye Disease, Shanghai, China. 3 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. 4 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. 5 Beijing Tongren Hospital, Capital Medical University, Beijing, China.）

出处： Frontiers in medicine 2022 Vol.8 P785126

关键词： age-related macular degeneration (AMD);anti-VEGF (vascular endothelial growth factor);bibliometric;pigment epithelial detachment;polypoidal choroidal vasculopathy (PCV).

摘要： Introduction: Polypoidal choroidal vasculopathy (PCV) is a special subtype of AMD, which is one of the leading threats to vision health worldwide. At ...

作者： Qi Zhou  ¹, Wenjie Zhu  ², Fuchen Li  ³, Mingqing Yuan  ¹, Linfeng Zheng  ⁴, Xu Liu  ¹ （Affiliations 1 Medical College of Guangxi University, Nanning, Guangxi,China. 2 Department of Emergency, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041,China. 3 College of Art and Science, Vanderbilt University, Nashville, Tennessee 37212, USA. 4 Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200042,China.）

出处： Current pharmaceutical design 2022 Vol.28 No.4 P287-295

关键词： CT scanning.;Deep learning;DenseNet diagnosis;ResNet;intracranial hemorrhage;transfer learning.

摘要： Objective: The aim of the study was to verify the ability of the deep learning model to identify five subtypes and normal images in non-contrast enhan ...