作者： Yafang Wang  ¹, Yang Liu  ¹, Shu Liu  ¹, Xiaomeng Li  ¹, Xinxin Liu  ^{1   2}, Ming Jiao  ³, Yuqin Yang  ³, Xueting Luo  ^{1   2}, Fenghua Wang  ^{1   2   4   5   6}, Xiaoling Wan  ^{1   2}, Xiaodong Sun  ^{1   2   4   5   6} （Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, China200080. 2 Shanghai Key Laboratory of Ocular Fundus Diseases, 100 Haining Road, Shanghai, China200080. 3 Laboratory Animal Center, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Shanghai, China201620. 4 Shanghai Engineering Center for Visual Science and Photomedicine, 100 Haining Road, Shanghai, China200080. 5 National Clinical Research Center for Eye Diseases, 100 Haining Road, Shanghai, China200080. 6 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 100 Haining Road, Shanghai, China200080.）

出处： Disease models & mechanisms 2022 Vol.15 No.3 Pdmm049222

关键词： Cyp4v3;Bietti crystalline dystrophy;Lipid accumulation;Mouse model;Retinal degeneration.

摘要： Bietti crystalline dystrophy (BCD) is an autosomal recessive inherited retinal disease, resulting in blindness in most patients. The etiology and deve ...

作者： Mengmeng Jiang  ¹, Hai Xie  ², Chaoyang Zhang  ^{3   4}, Tianqin Wang  ¹, Haibin Tian  ², Lixia Lu  ², Jing-Ying Xu  ², Guo-Tong Xu  ², Lin Liu  ¹, Jingfa Zhang  ^{3   4} （Affiliations 1 Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, China. 4 National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.）

出处： Journal of cellular and molecular medicine 2022

关键词： diabetic retinopathy;fractalkine;microglia;neuroinflammation.

摘要： The concept of diabetic retinopathy (DR) has been extended from microvascular disease to neurovascular disease in which microglia activation plays a r ...

作者： Yumeng Zhang  ¹, Zhenzhen Zhao  ¹, Xiaohuan Zhao  ¹, Hai Xie  ², Chaoyang Zhang  ¹, Xiaodong Sun  ³, Jingfa Zhang  ⁴ （Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. 2 Tongji Eye Institute, Department of Regenerative Medicine, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: xdsun@sjtu.edu.cn. 4 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: jingfa.zhang@shgh.cn.）

出处： Free radical biology & medicine 2022 Vol.181 P14-28

关键词： HMGB2;Oxidative stress;Photoreceptor;Pyroptosis;Retinal degeneration.

摘要： In the pathogenesis of retinal degenerative diseases, oxidative stress is a key driver leading to photoreceptor death and eventually vision loss. Curr ...

作者： Mengsha Sun ^{#  1}, Wenjia Liu ^{#  2}, Minwen Zhou  ^{3   4   5} （Affiliations 1 Department of Ophthalmology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. zmw8008@163.com. 4 National Clinical Research Center for Eye Diseases, Shanghai, China. zmw8008@163.com. 5 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. zmw8008@163.com.）

出处： Cell death discovery 2022 Vol.8 No.1 P50

摘要： Glaucoma is one of the leading causes of worldwide irreversible blindness. Lowering elevated intraocular pressure (IOP) is currently the only effectiv ...

作者： Jing Wu;Jing-Fa Zhang （Shanghai General Hospital(Shanghai First People\'s Hospital);National Clinical Research Center for Eye Diseases;Shanghai Key Laboratory of Ocular Fundus Diseases;Shanghai Engineering Center for Visual Science and Photomedicine;Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China Shanghai General Hospital(Shanghai First People\'s Hospital);National Clinical Research Center for Eye Diseases;Shanghai Key Laboratory of Ocular Fundus Diseases;Shanghai Engineering Center for Visual Science and Photomedicine;Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai 200080, China）

出处： Guoji Yanke Zazhi 2022 Vol.22 No.1 P53-56

关键词： hyperreflective foci;neuroinflammation;microglia;optical coherence tomography(oct)

摘要： Microglial activation is one of the main pathogenic factors to cause retinal neuroinflammation. Recently, with the advancement of retinal imaging tech ...

作者： Yanrui Jin^1,2;Jinlei Liu^1,2;Yunqing Liu^1,2;Chengjin Qin^1,2;Zhiyuan Li^1,2;Dengyu Xiao^1,2;Liqun Zhao³;Chengliang Liu^1,2 （1 School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China 2 MoE Key Lab of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University, Shanghai, China 3 Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, China）

出处： IEEE Transactions on Instrumentation and Measurement 2022 Vol.71 P1-11

关键词： Electrocardiography;Feature extraction;Rhythm;Convolutional neural networks;Deep learning;Diseases;Convolution

摘要： Arrhythmia accounts for more than 80% of sudden cardiac death, and its incidence rate has increased rapidly recently. Nowadays, many studies have appl ...

作者： Yu Tang¹;Yunke Bi²;Hao Wei¹;Zhongyu Hou¹;Zi Wang¹CA1 （1 National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Shanghai Jiao Tong University, Shanghai 200240, China; 2 Department of Neurosurgery, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 201620, China）

出处： Sensors and Actuators B: Chemical 2022 Vol.353 P131127

关键词： Hydrogen peroxide;Electrochemical sensor;Porous silicon;Metal-assisted chemical etching;Hierarchical structure

摘要： Herein we would like to introduce a general method for improving the dynamic range for electrochemical sensing devices based on 3D porous electrodes b ...

作者： Ying Cao ^{#  1}, Ye Tian ^{#  2   3}, Heng Zhang  ², Guang-Heng Luo  ², Zhao-Lin Sun  ², Shu-Jie Xia  ⁴ （Affiliations 1 Guizhou University School of Medicine, Guiyang, 550025, Guizhou, China. 2 Department of Urology, Guizhou Provincial People\'s Hospital, Guiyang, 550002, Guizhou, China. 3 Department of Urology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. 4 Department of Urology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. xsj4017@163.com.）

出处： International urology and nephrology 2022 Vol.54 No.3 P499-508

关键词： LUTS;Prostate fibrosis;Sex hormone;TGF-β/Smad signaling pathway.

摘要： Objective: The present study aimed to investigate the effects of an imbalance in the estrogen/androgen ratio on prostate fibrosis. Methods: Different ...

作者： Xueqing Yang^1,2;Shizhen Wang^3,2;Xiang Zhang⁴;Changqing Ye¹;Shige Wang¹CA1;Xiao An⁴CA2 （1 School of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai 200093, PR China; 2 These authors contributed equally to this work.; 3 Department of Basic Medicine, Jiangsu College of Nursing, No. 9 Keji Road, Huai\'an 223005, PR China; 4 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (originally named “Shanghai First People\'s Hospital”), No. 100 Haining Road, Shanghai 200080, PR China）

出处： Materials Science and Engineering: C 2022 P112677

关键词： Polyvinyl alcohol;Polydopamine;Embolization;Liver;CT imaging

摘要： The development of tissue adhesive embolization microspheres with imaging ability is one of the important methods to improve the efficacy of intervent ...

作者： Kaiyuan Liu  ¹, Yuxin Liao  ¹, Dong Yang  ¹, Tianyang Xu  ¹, Qiuming Gao  ¹, Wenwei Jiang  ¹, Lin Fan  ¹, Pengfei Zan  ², Guodong Li  ¹ （Affiliations 1 Department of Orthopedics, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, China. 2 Department of Orthopedics, Shanghai First People\'s Hospital, Jiaotong University School of Medicine, Shanghai, China.）

出处： Frontiers in surgery 2022 Vol.9 P692072

关键词： MIS-TKA;clinical effectiveness;gap balance;patellar position;soft tissue balance.

摘要： Background: We hypothesized that subluxating patellar during minimally invasive total knee arthroplasty (MIS-TKA) would affect intraoperative soft tis ...