作者： S Y Zhao  ¹, H M Liu  ², Q Lu  ³, X C Liu  ¹, J G Hong  ⁴, E M Liu  ⁵, Y X Zou  ⁶, M Yang  ⁷, Z M Chen  ⁸, H L Zhang  ⁹, D Y Zhao  ¹⁰, X B Zhang  ¹¹, Y Yin  ¹², X Y Dong  ³, X X Lu  ¹³, J R Liu  ¹, L N Chen  ² （Affiliations ¹ Department of No.2 Respiratory Medicine, Beijing Children's Hospital, Capital Medical University, National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing 100045, China. ² Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu 610041, China. ³ Department of Pulmonology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China. ⁴ Department of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China. ⁵ Department of Respiratory, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. ⁶ Department of Pulmonology, Tianjin Children's Hospital (Children's Hospital of Tianjin University), Machang Compus, Tianjin 300074, China. ⁷ Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China. ⁸ Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China. ⁹ Department of Pediatric Respiratory Medicine, the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China. ¹⁰ Department of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing 210008, China. ¹¹ Department of Respiratory Disease, Children's Hospital of Fudan University, Shanghai 201102, China. ¹² Department of Respiratory Medicine, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China. ¹³ Department of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430015, China.）

出处： Zhonghua er ke za zhi = Chinese journal of pediatrics 2024

摘要： 2023年肺炎支原体肺炎（MPP）在全国流行，国家卫生健康委员会于2023年2月发布“儿童肺炎支原体肺炎诊治指南”，但在实施过程中仍需要根据目前MPP特点，对重要诊治环节更加具体地指导和建议，现对MPP早期诊断方法、重症MPP判断依据和预警指标、各类抗支原体药物适应证、大环内酯类药物无反应性处理原则 ...

作者： Shangbi Chen  ^{1   2}, Dewen Liu  ^{1   2}, Weiwei Chen  ³, Huajiang Chen  ¹, Jiawei Li  ², Jinfang Wang  ² （Affiliations ¹ Shanghai Xin Yue Lian Hui Electronic Technology Co. Ltd, Shanghai, P.R. China. ² Inertial Technology Division, Shanghai Aerospace Control Technology Institute, Shanghai, P.R. China. ³ Department of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University School of Nursing, Shanghai, P.R. China.）

出处： Beilstein journal of nanotechnology 2024

关键词： crack sensors;helical structure;polydimethylsiloxane (PDMS);ultrahigh sensitivity;ultrahigh stretchability.

摘要： The majority of crack sensors do not offer simultaneously both a significant stretchability and an ultrahigh sensitivity. In this study, we present a ...

作者： Xiue Ma  ¹, Liming Gao  ², Rucun Ge  ³, Tianyou Yuan  ⁴, Bowen Lin  ⁵, Lixiao Zhen  ⁶ （Affiliations ¹ School of Medicine, Tongji University, Shanghai, 200092, China. ² Department of Cardiology, Ji'an Hospital, Shanghai East Hospital, Ji'an, 343000, Jiangxi, China. ³ Shandong Provincial Third Hospital, Shandong University, Jinan, 250012, Shandong, China. ⁴ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. tianyou_yuan@163.com. ⁵ School of Medicine, Tongji University, Shanghai, 200092, China. bowenlin0512@163.com. ⁶ Shandong Provincial Third Hospital, Shandong University, Jinan, 250012, Shandong, China. zlxiao56@163.com.）

出处： In vitro cellular & developmental biology. Animal 2024

关键词： AKT;CDC-like kinase 3;Cardiomyocyte apoptosis;Hypoxia.

摘要： Hypoxia-induced cardiomyocyte apoptosis is one major pathological change of acute myocardial infarction (AMI), but the underlying mechanism remains un ...

作者： Ximo Xu  ^{1   2}, Hao Zhong  ¹, Jun You  ³, Mingyang Ren  ⁴, Abe Fingerhut  ^{1   5}, Minhua Zheng  ¹, Jianwen Li  ¹, Xiao Yang  ¹, Haiqin Song  ¹, Sen Zhang  ¹, Chengsheng Ding  ¹, Naijipu Abuduaini  ¹, Mengqin Yu  ¹, Jingyi Liu  ¹, Yi Zhang  ¹, Liang Kang  ^{6   7}, Zhenghao Cai  ¹, Bo Feng  ¹ （Affiliations ¹ Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai. ³ Department of Gastrointestinal Surgery, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen. ⁴ Department of Gastrointestinal Surgery, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Nanchong. ⁵ Section for Surgical Research, Department of Surgery, Medical University of Graz, Auenbruggerplatz 29, Graz, Austria. ⁶ Department of General Surgery (Colorectal Surgery). ⁷ Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.）

出处： International journal of surgery (London, England) 2024

摘要： Background: With the optimization of neoadjuvant treatment regimens, the indications for intersphincteric resection (ISR) have expanded. However, limi ...

作者： Chen, Yuhong^a,b;Chen, Jieqiong^a,b;Wang, Hong^a,b;Yu, Yang^a;Wang, Wenqiu^a,b;Liu, Wenjia^a,b;Yu, Suqin^a,b;Gong, Yuanyuan^a,b;Jia, Huixun^a,b,c;Li, Tong^a,bCAa;Sun, Xiaodong^a,b,c,dCAb （^aDepartment of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;^bNational Clinical Research Center for Ophthalmic Diseases, Shanghai, China;^cShanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China;^dShanghai Key Laboratory of Fundus Diseases, Shanghai, China）

出处： Eye (Basingstoke) 2024

摘要： Background: To investigate the prevalence of outer retinal tubulation (ORT) and its correlations with optical coherence tomography (OCT) parameters in ...

作者： Lingzhou Zhao¹;Yan Xing¹;Changcun Liu¹;Shaofei Ma²;Wenhua Huang³;Zhen Cheng^4,5CA1;Jinhua Zhao¹CA2 （¹Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Hongkou District, 200080, Shanghai, China;²Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Road, Hongkou District, 200080, Shanghai, China;³Nanomab Technology Limited, No. 333, North Chengdu Road, Jingan District, 200041, Shanghai, China;⁴State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555, Zuchongzhi Road, Pudong New District, 201203, Shanghai, China;⁵Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, No. 198, Binhai East Road, High-Tech District, 264000, Yantai, Shandong, China）

出处： Breast Cancer Research 2024

关键词： HER2;Breast cancer;Nanobody;SPECT/CT imaging;^99mTc

摘要： Background ^99mTc radiolabeled nanobody NM-02 (^99mTc-NM-02) is a novel single photon emission computed tomography (SPECT) probe ...

作者： Yu Tian¹;Li Wang²;Yunyun Qian³;Ling Li¹;Hao Li³CA1;Xuejiao Song¹;Minjia Wang¹;Najia Zhu⁴;Yao Tong⁴;Wenbo Wu⁴CA2;Leilei Shi²CA3 （¹The Eighth Affiliated Hospital Sun Yat-sen University, 3025 Shennan Middle Road, Shenzhen 518000, China;²Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;³Department of Organ Transplantation, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361005, Fujian, China;⁴Institute of Molecular Aggregation Science, Tianjin University, Tianjin 300072, China）

出处： ACS Materials Letters 2024

摘要： The design of a biologically active photosensitizer that effectively combines chemotherapy and photodynamic therapy remains a significant challenge. T ...

作者： Hui-Yi Li¹;Yu-Xuan Gao¹;Jun-Cheng Wu³;Jing-Ze Li⁴;Seng-Wang Fu²CA1;Ming-Yi Xu¹CA2 （¹Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, No. 551, Pudong-South Road, 200120, Shanghai, China;²Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100, Haining Rd, 200080, Shanghai, China;³Departments of Gastroenterology, The Third Affiliated Hospital of Soochow University, 213000, Changzhou, Jiangsu, China;⁴Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, 200120, Shanghai, China）

出处： Cell & Bioscience 2024

关键词： Non-alcoholic steatohepatitis (NASH);Liver sinusoidal endothelial cell (LSEC);Single-cell RNA sequencing (scRNA-seq);KIT proto-oncogene receptor tyrosine kinase (C-Kit);Mitophagy

摘要： Aim To understand how liver sinusoidal endothelial cells (LSECs) respond to nonalcoholic steatohepatitis (NASH). Methods We profiled single-LSEC fr ...

作者： Yingying Liao¹;Jiahui Ye¹;Luoyijun Xie¹;Longfei Mao²;Jiangcun Wei³;Chutong Liu¹;Jing Liang³;Jianlong Zhou³CA1;Miaomiao Yuan^1,4CA2;Zujie Qin³CA3 （¹The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518017, China;²Key Laboratory of Green Chemical Media and Reactions (Ministry of Education), Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, Henan, China;³Guangxi International Zhuang Medicine Hospital, Guangxi University of Chinese Medicine, Nanning 530201, China;⁴Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China）

出处： ACS Applied Nano Materials 2024

关键词： nonsmall cell lung cancer;chemo-photodynamic therapy;nanoparticles;d17;Ce6

摘要： The theophylline derivative d17 is a candidate drug for nonsmall cell lung cancer (NSCLC) treatment previously developed by our group. However, it has ...

作者： Bingxin Xu¹;Jindong Yao¹;Wenqi Song¹;Xinyi Yan¹;Ming Zhu¹;Jiangtao Li²;Zhonglin Ma²;Yanchuan Li³;Yihao Li³;Yanbin Fu⁴;Liu Liu⁵;Lei Li⁶CA1;Jianjun Lyu³CA2;Chao Zhang¹CA3 （¹Fundamental Research Center, Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Life Sciences and Technology, Tongji University, Shanghai 201619, P.R. China;²State Key Laboratory of Marine Geology, School of Ocean and Earth Science, Tongji University, Shanghai 200092, P.R. China;³Hubei Topgene Research Institute of Hubei Topgene Biotechnology Co., Ltd., East Lake High-Tech Development Zone, Wuhan 430205, P.R. China;⁴Shanghai Cancer Institute, Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, P.R. China;⁵Shanghai Yuhui Pharmaceutical Technology (Group) Co., Ltd., and Shanghai Ruishen Technology Development Co., Ltd., Shanghai 201203, P.R. China;⁶Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China）

出处： ACS Pharmacology & Translational Science 2024

关键词： MC4R;constitutive activity;second intracellular loop

摘要： Melanocortin-4 receptor (MC4R) functions as a crucial neuroendocrine G protein-coupled receptor (GPCR) in the central nervous system of mammals, displ ...