作者： Moran Huang^1,21;Zhengchao Yuan^3,22;Guojian Fu^1,23;Jize Dong¹4;Yaying Sun¹5;Wenxin Wang³6;Muhammad Shafiq⁴7;Huiliang Cao⁵8;Xiumei Mo³CA9;Jiwu Chen¹CA10 （¹Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;²These authors contributed equally.;³State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China;⁴Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kawasaki-ku, Kawasaki, 210-0821, Japan;⁵Interfacial Electrochemistry and Biomaterials, School of Materials Science and Engineering, East China University of Science & Technology, Shanghai, 200237, China）

出处： Composites Part B: Engineering 2025

摘要： Surgical repair is recommended for meniscus tear to avoid knee degeneration. However, postoperative meniscal healing remains challenging due to limite ...

作者： Shuai Yang^1,2,3;Xiaoyi Kong^1,3;Xiangxia Zhang^4,3;Yueming Zhang¹;Xueyan Li¹;Yi-Jun Ge^5,1CA1 （¹Department of Neurology (Sleep Disorders), Affiliated Chaohu Hospital of Anhui Medical University, Hefei, Chaohu, PR China;²Department of Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, PR China;³These authors contributed equally to this work.;⁴Hefei Good Every Day Rehabilitation Medical Center, Hefei, PR China;⁵Department of Sleep Disorders, Bengbu Hospital of Shanghai General Hospital, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, PR China）

出处： Sleep Medicine 2025

关键词： Insomnia;Major depressive disorder;Prefrontal cortex;Function near-infrared spectroscopy;Verbal fluency task

摘要： Background Insomnia often co-occurs with major depressive disorder (MDD) and significantly affects patient recovery and prognosis. However, how insomn ...

作者： Min Tang^1,2,3;Xiaohui Wei^1,3;Yunqin Ma^1,3;Yijiong Tan⁴;Han Cao^5,6;Shuangshuang Yao¹;Jiaqi Wang¹;Hua Yang²;Fang Liu¹;Yongde Peng^1,5CA1;Nengguang Fan¹CA2 （¹Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Department of Endocrinology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;³These authors contributed equally to this work.;⁴Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁵Department of Endocrinology and Metabolism, Shanghai General Hospital of Nanjing Medical University, Shanghai, China;⁶Department of Endocrinology, Songjiang District Central Hospital, Shanghai, China）

出处： Life Sciences 2025

摘要： Objective The role of ubiquitin-specific protease 13 (USP13) in metabolic dysfunction-associated steatohepatitis (MASH) remains unclear. This study ai ...

作者： Xiaohua Wang^1,2,3;Xinjuan Qu^4,3;Xuelai Liu⁴;Kaiyue Wang⁵;Yongfang Yang⁶;Yujuan Zhang⁷;Zhenguo Wang⁴;Guangjian Fan⁸;Yuming Li⁹;Yuanyuan Zeng⁹CA1;Hongwei Chen^8,10,3CA2;Ting Zhu⁸CA3 （¹Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, 510006, China;²Department of General Internal Medicine, Linyi People's Hospital, No.27 Jiefang Road, Lanshan District, Linyi City, Shandong Province, 276003, China;³These authors contributed equally to this work.;⁴Department of Neurology, Linyi Hospital of Traditional Chinese Medicine, Shandong, 276002, China;⁵Department of Neurology, Linyi People's Hospital, Linyi, Shandong Province, 276003, China;⁶Department of Rehabilitation, Linyi People's Hospital, Linyi, Shandong Province, 276003, China;⁷Department of Acupuncture and Moxibustion, Linyi People's Hospital, Linyi, Shandong Province, 276003, China;⁸Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200080, China;⁹Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200080, China;¹⁰Department of Clinical Laboratory, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (Preparatory Stage), Shanghai 201600, China）

出处： Biochemistry and Biophysics Reports 2025

关键词： Glioma;Tumor progression;KLF14;FOSL1;Transcriptional inhibition

摘要： Background Glioma, the most frequent central nervous system malignancy, is often promoted by the overexpression of Fos-like antigen 1 (FOSL1). However ...

作者： Jiajun Li^1,2;Chi Zhang^1,2;Qingqing Zhou^1,2;Qinqin Long^3,4,2;Jiayi Chen^5,2;Lili Meng^6,2;Wei Tian¹;Yue Yang¹;Chao Ge¹;Yuting Su¹;Xi-Dai Long^3,4CA1;Jun Wu⁵CA2;Hua Tian^1,3,4CA3 （¹State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²These authors contributed equally.;³Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China;⁴The Key Laboratory of Molecular Pathology in Tumors of Guangxi Higher Education Institutes, Baise, China;⁵Department of Laboratory Medicine, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁶Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China）

出处： JHEP Reports 2025

关键词： ALDH1L2;Feedback loop;TAM;Crosstalk;Progression;Hepatocellular carcinoma

摘要： Background & Aims Dysregulation of one-carbon metabolism is considered an early hallmark of mitochondrial dysfunction and cancer metabolism. ALDH1L2 b ...

作者： Meng Gu  ¹, Jiajun Fang  ², Zhongmei Shao  ³, Hui Yu  ¹, Senchao Guo  ¹, Yang Gao  ¹, Xiaojin He  ⁴, Yuping Xu  ⁵, Mingrong Lv  ⁶ （Affiliations ¹ Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China. ² The First Clinical Medical College of Anhui Medical University, Hefei 230032, China. ³ Anhui No. 2 Provincial People's Hospital, Hefei, Anhui 230012, China. ⁴ NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address: allin0701@126.com. ⁶ Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address: lvmingrong2016@163.com.）

出处： Gene 2025

关键词： Assisted reproductive technology;ERCC6;FOXL2;Female infertility;Premature ovarian insufficiency.

摘要： Premature ovarian insufficiency (POI) is the main cause of infertility in women. Some cases of POI are thought to be caused by genetic defects and the ...

作者： Qiu-Yang Zhang^1,2,3;Hui-Ying Zhang^2,3;Si-Guo Feng^2,3;Mu-Di Yao⁴;Jing-Juan Ding²;Xiu-Miao Li¹;Rong Ye²;Qing Liu²;Jin Yao^1,2CA1;Biao Yan^4,5CA2 （¹The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China;²The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China;³These authors contributed equally to this work.;⁴Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;⁵Eye Institute and Department of Ophthalmology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200030, China）

出处： Redox Biology 2025

关键词： Vascular dysfunction;Macrophage homeostasis;Circular RNAs;Diabetic retinopathy;Metabolic reprogramming

摘要： Macrophages play an important role in the development of vascular diseases, with their homeostasis closely linked to metabolic reprogramming. This stu ...

作者： Xin Liu^1,2,3,4,5;Yue Wu^1,2,3,4,5;Yuying Liu^1,2,3,4,5;Wenzhe Qian^1,2,3,4,5;Liandi Huang^1,2,3,4,5;Yixiang Wu^1,2,3,4,5;Bilian Ke^1,6,2,3,4,5CA1 （¹Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China;²National Clinical Research Center for Eye Diseases, Shanghai, China;³Shanghai Key Laboratory of Fundus Disease, Shanghai, China;⁴Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China;⁵Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China;⁶Department of Ophthalmology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai, 200127, China）

出处： Experimental Eye Research 2025

摘要： Pathological myopia (PM) is associated with ocular morbidities that cause blindness. PM often occurs in eyes with high myopia (HM) while they are dist ...

作者： Xiaomin Luo¹;Fang Liu²;Lijun Zhu³;Caizhi Liu⁴;Ruhui Shen⁵;Xiaoyin Ding¹;Yufan Wang¹;Xiaofang Tang⁶;Yongde Peng²;Zhijian Zhang² （¹Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Corresponding author.;³Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China;Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Centre for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China;⁵Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁶Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Corresponding author.）

出处： Molecular Metabolism 2025

关键词： Gluconeogenesis;Hepatic nuclear factor 4α;Leupaxin;Glucose metabolism;Metabolic disorders

摘要： Background: As the primary source of glucose during fasting, hepatic gluconeogenesis is rigorously regulated to maintain euglycemia. Abnormal gluconeo ...

作者： Yun Xie^1,2;Jiajun Wu^1,2;Shun Zhu^1,2;Ruilan Wang²CA1 （¹These authors are contributed equally.;²Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, Shanghai, 201600, PR China）

出处： Psychiatry Research 2025