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作者: Zilin Yang  1, Jia Huang  1, Xuejiao Wu  1, Yufen Zhou  2, Yuming Tang  1, Ying Zhu  1, Baiwen Li  3, Xi Chen  4, Weiyan Yao  1 (Affiliations 1 Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. 2 Department of Gastroenterology, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 201801, China. 3 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. 4 State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Sciences, Nanjing University, Nanjing, Jiangsu, 210023, China.)

出处: Journal of Cancer 2024

关键词: 2'-O-methylation;Circulating microRNA;Diagnosis;Pancreatic ductal adenocarcinoma;Plasma biomarkers.

摘要: Background: We conducted an assessment of 2'-O-methylated (2'OMe) microRNAs (miRNAs) present in the circulation of individuals suffering from pancreat ...

作者: Jinzhong Zhang  1, Xiaolong Zha  2, Gengxin Liu  3, Huipeng Zhao  4, Xiaoyun Liu  4, Liusheng Zha  1 (Affiliations 1 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China. lszha@dhu.edu.cn. 2 Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. m13524282806@163.com. 3 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Center for Advanced Low-dimension Materials, College of Material Science and Engineering, Donghua University, Shanghai 201620, China. 4 Research Center for Analysis and Measurement, Donghua University, Shanghai 201620, China. xyliu@dhu.edu.cn.)

出处: Materials horizons 2024

摘要: To date, the reported injectable hydrogels have failed to mimic the fibrous architecture of the extracellular matrix (ECM), limiting their biological ...

作者: Ge Shu  1, Wenjin Chen  2, Chenchen Huang  3, Hui Shan  4, Jing Ye  1, Jianfa Li  5   6, Yaoting Gui  1 (Affiliations 1 Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China. 2 Department of Neurosurgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China. 3 Department of Urology, Peking University First Hospital, Beijing, China. 4 Institute of Precision Medicine, Peking University Shenzhen Hospital, Shenzhen, China. 5 Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. 6 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Journal of Cancer 2024

关键词: BAX;P7C3;RRM2;cGAS-STING;renal cell carcinoma.

摘要: Background: P7C3 is a novel compound that has been widely applied in neurodegenerative diseases and nerve injury repair. Here, we show that higher con ...

作者: Yong-Wei Xiong #  1   2, Hua-Long Zhu #  1   2, Jin Zhang #  1   2, Hao Geng #  3   4   5, Lu-Lu Tan  1   2, Xin-Mei Zheng  1   2, Hao Li  1   2, Long-Long Fan  1   2, Xin-Run Wang  1   2, Xu-Dong Zhang  1   2, Kai-Wen Wang  1   2, Wei Chang  1   2, Yu-Feng Zhang  1   2, Zhi Yuan  1   2, Zong-Liu Duan  3   4   5, Yun-Xia Cao  3   4   5, Xiao-Jin He  6   7, De-Xiang Xu  8   9   10, Hua Wang  11   12   13 (Affiliations 1 Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, China. 2 Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei, China. 3 Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. 4 NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, China. 5 Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, China. 6 NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, China. hxj0117@126.com. 7 Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hxj0117@126.com. 8 Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, China. xudex@126.com. 9 Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei, China. xudex@126.com. 10 Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, China. xudex@126.com. 11 Department of Toxicology, School of Public Health, Anhui Medical University, Hefei, China. wanghuadev@ahmu.edu.cn. 12 Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Hefei, China. wanghuadev@ahmu.edu.cn. 13 Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, China. wanghuadev@ahmu.edu.cn.)

出处: Nature communications 2024

摘要: There is strong evidence that obesity is a risk factor for poor semen quality. However, the effects of multigenerational paternal obesity on the susce ...

作者: Zhiqiang Zhang #  1   2, Shan Wang #  1, Lulu Jiang #  3, Jianwen Wei #  4, Chang Lu #  5, Shengli Li  6, Yizhu Diao  7, Zhongcheng Fang  1   2, Shuo He  8, Tingting Tan  1, Yisheng Yang  1, Kexin Zou  1   2, Jiantao Shi  9, James Lin  4, Liye Chen  10, Chaohui Bao  11   12, Jian Fei  13   14, Hai Fang  15 (Affiliations 1 Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. 2 School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China. 3 Translational Health Sciences, University of Bristol, Bristol, BS1 3NY, UK. 4 Network and Information Center, Shanghai Jiao Tong University, Shanghai, 200240, China. 5 MRC London Institute of Medical Sciences, Imperial College London, London, W12 0HS, UK. 6 Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. 7 College of Finance and Statistics, Hunan University, Changsha, 410079, Hunan, China. 8 College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. 9 Key Laboratory of RNA Science and Engineering, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China. 10 Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK. liye.chen@ndorms.ox.ac.uk. 11 Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. chaohuibao@sjtu.edu.cn. 12 Department of General Surgery, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, 200020, China. chaohuibao@sjtu.edu.cn. 13 Department of General Surgery, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, 200020, China. feijian@hotmail.com. 14 Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. feijian@hotmail.com. 15 Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. fh12355@rjh.com.cn.)

出处: Communications biology 2024

摘要: While genome-wide studies have identified genomic loci in hosts associated with life-threatening Covid-19 (critical Covid-19), the challenge of resolv ...

作者: Tingting Xu #  1, Yuehan Chen #  1, Wenzhi Zhan #  1, Kian Fan Chung #  2   3, Zhongmin Qiu #  4, Kewu Huang #  5, Ruchong Chen #  1, Jiaxing Xie #  1, Gang Wang  6, Min Zhang  7, Xuefen Wang  8, Hongmei Yao  9, Xiuqing Liao  10, Yunhui Zhang  11, Guojun Zhang  12, Wei Zhang  13, Dejun Sun  14, Jia Zhu  15, Shujuan Jiang  16, Juntao Feng  17, Jianping Zhao  18, Gengyun Sun  19, Huaqiong Huang  20, Jianyong Zhang  21, Lingwei Wang  22, Feng Wu  23, Suyun Li  24, Pusheng Xu  25, Chunhua Chi  26, Ping Chen  27, Mei Jiang  1, Wen He  1, Lianrong Huang  1, Wei Luo  1, Shiyue Li  1, Nanshan Zhong  1, Kefang Lai  1; China Cough Coalition  28 (Affiliations 1 State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. 2 Department of Respiratory Medicine, Royal Brompton and Harefield Hospital, London, United Kingdom. 3 Experimental Studies Unit, National Heart & Lung Institute, Imperial College London, London, United Kingdom. 4 Department of Pulmonary and Critical Care Medicine, School of Medicine, Tongji Hospital, Tongji University, Shanghai, China. 5 Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. 6 West China School of Medicine, West China Hospital of Sichuan University, Chengdu, China. 7 Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. 8 Department of Respiratory Medicine, The First Affliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 9 Department of Respiratory Medicine, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China. 10 Department of Respiratory Medicine, Fuling Center Hospital of Chongqing, Chongqing, China. 11 The First People's Hospital of Yunnan Province, Kunming, China. 12 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 13 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China. 14 Department of Pulmonary and Critical Care Medicine, the Inner Mongolia Autonomous Region People's Hospital, Hohhot, China. 15 Department of Respiratory Medicine, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. 16 Department of Pulmonary Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China. 17 Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, China. 18 Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College of Hua Zhong University of Science and Technology, Wuhan, China. 19 Department of Respiratory Medicine, The First Affiliated Hospital of Medical University of Anhui, Hefei, China. 20 Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. 21 The Second Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China. 22 Shenzhen People's Hospital, Shenzhen Institute of Respiratory Diseases, Shenzhen, China. 23 Department of Pulmonary and Critical Care Medicine, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, China. 24 The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China. 25 The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. 26 Department of Respiratory and Critical Care Medicine, Peking University First Hospital, Beijing, China. 27 General Hospital of Northern Theater Command, Shenyang, China. 28 See Acknowledgments, .)

出处: JMIR public health and surveillance 2024

关键词: COVID-19;Omicron variant;cough;nonhospitalized.

摘要: Background: Cough is a common symptom during and after COVID-19 infection; however, few studies have described the cough profiles of COVID-19. Objecti ...

作者: G Wang1;D Luo1;F Song1;Z Sun1;P Dong1;Z Zhu*11Department of Otolaryngology, Shanghai General Hospital, Jiaotong University School of Medicine, Shanghai City, China)

出处: The Journal of Laryngology & Otology 2024

关键词: Auricle pseudocyst;intensified negative drainage;treatment;recurrence

摘要: Objective Auricular pseudocysts are rare, painless, benign intracartilaginous cysts of the auricle that are not lined by epithelium and have no known ...

作者: Siqi Zheng, MM, Min Bai, MM11Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Advanced Ultrasound in Diagnosis and Therapy 2024

关键词: ultrasonography;elastography;diabetes mellitus;peripheral neuropathy

摘要: Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes, which can lead to neuropathic pain, foot ulcers, and ...

作者: Yazhou Wang  1   2, Chenghao Zhou  3, Huabin Yin  3, Dianwen Song  4   5 (Affiliations 1 Department of Orthopedics, Shanghai Songjiang District Central Hospital, Shanghai, China. 2 Department of Orthopedics, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. 3 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 650 New Songjiang Road, Songjiang District, Shanghai, 200080, China. 4 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 650 New Songjiang Road, Songjiang District, Shanghai, 200080, China. dianwen_song@126.com. 5 Department of Orthopedics, Shanghai General Hospital of Nanjing Medical University, Shanghai, China. dianwen_song@126.com.)

出处: European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 2024

关键词: Cement-augmented pedicle screw;Complication;Lumbar degenerative patients;Osteoporosis;Spinal internal fixation.

摘要: Study design: A retrospective cohort study. Objective: To compare the safety and clinical efficacy between using cement-augmented pedicle screws (CAPS ...

作者: Hui Li, MD, Nan Zheng, MD, Penglin Zou, MD, Chao Jia, MD, Long Liu, MD, Gang Li, MD, Ziqi Wang, MD, Rong Wu, MD, Lianfang Du, MD, Qiusheng Shi, MD11aDepartment of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;bDepartment of ultrasound, Henan Jiaozuo People’s Hospital, Jiaozuo, China)

出处: Advanced Ultrasound in Diagnosis and Therapy 2024

关键词: sarcoidosis;ultrasonography;radiography;nuclear medicine;interventional ultrasound

摘要: Sarcoidosis is a granulomatous disease of unknown etiology that can involve various organs and tissues. The clinical manifestations vary greatly, so i ...

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