作者： Xiaolu Ge ^{#  1}, Chao Du ^{#  2}, Li Fang  ³, Wei Xu  ², Juanjuan Xiang  ², Jiheng Liu  ⁴, Ming Zhou  ², Yuejun Chen  ³, Ziyao Wang  ^{5   6}, Zheng Li  ⁷ （Affiliations ¹ Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, PR China. ² The First Department of Thoracic Surgery, Hunan Cancer Hospital and the affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, PR China. ³ NHC Key Laboratory of Carcinogenesis, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan, PR China. ⁴ Department of Hematology & Oncology, First Hospital of Changsha, Changsha, Hunan, PR China. ⁵ The First Department of Thoracic Surgery, Hunan Cancer Hospital and the affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, PR China. wangziyao@hnca.org.cn. ⁶ NHC Key Laboratory of Carcinogenesis, Xiangya School of Basic Medical Sciences, Central South University, Changsha, Hunan, PR China. wangziyao@hnca.org.cn. ⁷ The First Department of Thoracic Surgery, Hunan Cancer Hospital and the affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, PR China. lizheng@csu.edu.cn.）

出处： Communications biology 2025

摘要： Angiogenesis is a significant character of lung adenocarcinoma (LUAD) and is an important reason leading to high mortality rates of LUAD patients. How ...

作者： Xiaodong Song ^{#  1}, Yu Zhang ^{#  1}, Tiewen Li ^{#  1}, Wenhao Wang  ¹, Zhiwen Xie  ¹, Bangmin Han  ² （Affiliations ¹ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. hanbm@163.com.）

出处： Molecular biotechnology 2025

关键词： Alkaliptosis;Biochemical recurrence-free survival;Bioinformatics;Prostate cancer.

摘要： Androgen deprivation therapy (ADT) is the primary treatment strategy for prostate cancer. However, despite an initially favorable response, tumors ine ...

作者： Meng-Qi Zhao  ^{1   2   3}, Miao-Yan Fan  ^{2   3}, Meng-Yan Cui  ^{2   3}, Su-Min Chen  ¹, Jing-Jing Wang  ³, Ying-Ying Lu  ^{4   5}, Qiao-Li Jiang  ⁶ （Affiliations ¹ Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai, 201803, China. ² Department of Gastroenterology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 201620, China. ³ Shanghai Key Laboratory of Pancreatic Diseases, Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ⁴ Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai, 201803, China. le_voyageur@sjtu.edu.cn. ⁵ Department of Gastroenterology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 201620, China. le_voyageur@sjtu.edu.cn. ⁶ Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 800 Huangjiahuayuan Road, Shanghai, 201803, China. mqzh0547@sjtu.edu.cn.）

出处： Gut pathogens 2025

关键词： Acute pancreatitis;Candida;Fungal diversity;Fungi;Gut microbiota.

摘要： Objective: The gut is involved in the development of acute pancreatitis (AP). Increased focus is being given to the role of gut microbiota in the path ...

作者： Junying Wei  ¹, Heshan Cao  ², Mingling Peng  ¹, Yinzhou Zhang  ³, Sibei Li  ⁴, Wuhua Ma  ⁵, Yuhui Li  ⁵ （Affiliations ¹ First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. ² Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. ³ Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. ⁴ Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. ⁵ Department of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.）

出处： PloS one 2025

摘要： Background: Ventilator-associated pneumonia (VAP) is a common nosocomial infection in ICU, significantly associated with poor outcomes. However, there ...

作者： Yun Xie  ¹, Ruilan Wang  ² （Affiliations ¹ Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, People's Republic of China. ² Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, People's Republic of China. Electronic address: wangyusun@hotmail.com.）

出处： Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2025

作者： Ruqiang Yuan ^{#  1}, Mingjing Gao ^{#  2   3}, Hu Xu ^{#  4}, Qing Liang  ¹, Lei Qian  ¹, Yali Wang  ¹, Houli Zhang  ⁵, Erjiao Qiang  ⁶, Weijing Yun  ⁷ （Affiliations ¹ Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China. ² Department of Pharmacy, Dalian Port Hospital, Dalian, 116001, China. ³ College of Pharmacy, Dalian Medical University, Dalian, 116044, China. ⁴ Wuhu Hospital and Health Science Center, East China Normal University, Shanghai, 200241, China. ⁵ College of Pharmacy, Dalian Medical University, Dalian, 116044, China. houlizh@163.com. ⁶ Department of Pathology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China. qiangerjiao@126.com. ⁷ Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, 116044, China. yunweijing@dmu.edu.cn.）

出处： BMC cardiovascular disorders 2025

关键词： Calcium influx;Alantolactone;Hypertension;Voltage-gated Calcium Channels.

摘要： Background: The dried root of Inula helenium L., known as Inulae Radix in Mongolian medicine, is a widely used heat-clearing plant drug within the Ast ...

作者： Ying Zhang ^{#  1   2   3}, Yan Ma ^{#  1   2}, Yu-Ke Ji ^{#  1   2}, Yi-Fei Jiang  ^{1   2}, Duo Li  ^{1   2}, Wan Mu  ⁴, Mu-Di Yao  ⁵, Jin Yao  ^{6   7}, Biao Yan  ⁸ （Affiliations ¹ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. ² The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. ³ Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. ⁴ Eye Institute, Department of Ophthalmology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200030, China. ⁵ Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. mudiyao@163.com. ⁶ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. jinyao1972@126.com. ⁷ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. jinyao1972@126.com. ⁸ Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. yanbiao@sjtu.edu.cn.）

出处： Cell communication and signaling : CCS 2025

关键词： Ischemic/reperfusion injury;Müller cells;Reactive gliosis;Retinal ganglion cells;tsRNA.

摘要： Ischemic retinopathies are the major causes of blindness, yet effective early-stage treatments remain limited due to an incomplete understanding of th ...

作者： Zhiqiang Wang  ¹, Yunqi Guo  ¹, Gaoming Li  ¹, Meijuan He  ², Yanying Li  ¹, Zhiyun Liu  ¹, Han Wang  ², Mingwu Shen  ¹, Xiangyang Shi  ¹ （Affiliations ¹ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China. ² Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.）

出处： ACS applied materials & interfaces 2025

关键词： antibody delivery;combined tumor therapy;dendrimer;immune activation;metal-phenolic network.

摘要： To simplify the composition and improve the efficacy of metal-phenolic network (MPN)-based nanomedicine, herein, we designed an MPN platform to delive ...

作者： Hao-Wei Bai  ¹, Na Li  ¹, Yu-Xiang Zhang  ¹, Jia-Qiang Luo  ¹, Ru-Hui Tian  ¹, Peng Li  ¹, Yu-Hua Huang  ¹, Fu-Rong Bai  ¹, Cun-Zhong Deng  ¹, Fu-Jun Zhao  ¹, Ren Mo  ², Ning Chi  ², Yu-Chuan Zhou  ^{3   4}, Zheng Li  ¹, Chen-Cheng Yao  ¹, Er-Lei Zhi  ¹ （Affiliations ¹ Department of Andrology, The Center for Men's Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China. ² Department of Urology, Inner Mongolia People's Hospital, Inner Mongolia Urological Institute, Hohhot 010017, China. ³ International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China. ⁴ Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200000, China.）

出处： Asian journal of andrology 2025

摘要： Nonobstructive azoospermia (NOA), one of the most severe types of male infertility, etiology often remains unclear in most cases. Therefore, this stud ...

作者： Ying Cao  ¹, Ruolan Qian  ¹, Ruilian Yao  ², Quan Zheng  ³, Chen Yang  ¹, Xupeng Yang  ⁴, Shuyi Ji  ⁴, Linmen Zhang  ¹, Shujie Zhan  ¹, Yiping Wang  ⁵, Tianshi Wang  ⁶, Hui Wang  ¹, Chun-Ming Wong  ⁷, Shengxian Yuan  ⁸, Christopher Heeschen  ³, Qiang Gao  ⁴, René Bernards  ⁹, Wenxin Qin  ¹⁰, Cun Wang  ¹¹ （Affiliations ¹ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. ³ Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Liver Surgery and Transplantation, Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China. ⁵ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Nephrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ State Key Laboratory for Liver Research and Department of Pathology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China. ⁸ The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China. ⁹ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Electronic address: r.bernards@nki.nl. ¹⁰ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: wxqin@sjtu.edu.cn. ¹¹ State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: cwang@shsci.org.）

出处： Developmental cell 2025

关键词： DYRK1A;IACS-010759;TGF-β signaling;hepatocellular carcinoma;oxidative phosphorylation.

摘要： Intervening in mitochondrial oxidative phosphorylation (OXPHOS) has emerged as a potential therapeutic strategy for certain types of cancers. Employin ...