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作者: Kaili Wang1;Xiaoyun Wang2;Di Jiang1;Yifei Pei1;Zhe Wang1;Xiaojun Zhou1;Jinglei Wu1;Xiumei Mo1;Hongsheng Wang1CA1 (1 Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Key Laboratory of Science & Technology of Eco-Textile (Ministry of Education), College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, PR China; 2 Department of Obstetrics & Gynecology, Shanghai First People\'s Hospital Affiliated to Shanghai JiaoTong University, Shanghai, 201620, PR China)

出处: Composites Part B: Engineering 2022 Vol.233 P109648

关键词: Transcutaneous immunization;mRNA vaccines;Immune checkpoint blocker;Ethosome;Dendritic cells;Tumor immunotherapy

摘要: This study aimed to deliver mRNA vaccines and immune checkpoint blockers (ICB) with a transcutaneous immunization (TCI) system based on ethosomes (ETH ...

作者: Ying Shen  1, Junxian Li  2, Hairong Tian  3, Ye Ji  3, Ziyun Li  3, Junxi Lu  4, Huijuan Lu  4, Bo Liu  3, Fang Liu  2   4 (Affiliations 1 Department of Endocrinology & Metabolism, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, China. 2 Department of Endocrinology & Metabolism, Shanghai Jiao-Tong University School of Medicine Affiliated Shanghai General Hospital, Shanghai, China. 3 Department of Endocrinology and Metabolism, Jin Shan Branch of Shanghai Sixth People\'s Hospital, Shanghai, China. 4 Department of Endocrinology & Metabolism, Shanghai Key Laboratory of Diabetes, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai Institute for Diabetes, Shanghai Jiao-Tong University Affiliated Sixth People\'s Hospital, Shanghai, China.)

出处: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2022 Vol.38 No.2 P158-163

关键词: Complement factor Ba;first prenatal test of gestation;gestational diabetes mellitus;perinatal outcome;propensity score-matched.

摘要: Objective: This study was to assess the alteration of circulating complement factor Ba (CFBa) within 11 to 17 weeks of gestation and its association w ...

作者: Shanshan Hu  1, Shuowen Wang  1, Chendong Qi  1, Shengying Gu  1, Chenyang Shi  1, Lin Mao  1, Guorong Fan  1 (Affiliation 1 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Frontiers in pharmacology 2022 Vol.13 P831364

关键词: UKPDS OM;cost-utility analysis;dulaglutide;extended-release exenatide;once-weekly GLP-1 receptor agonist;subcutaneous semaglutide;type 2 diabetes.

摘要: Introduction: The substantial financial burden associated with type 2 diabetes (T2D) over a lifetime cannot be neglected. Therefore, the objective of ...

作者: Sijia He  1, Qi Li  1, Qian Huang  1, Jin Cheng  1 (Affiliation 1 Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.)

出处: Cancers 2022 Vol.14 No.5 P1104

关键词: cancer;cell death;protein kinase C;targeted therapy.

摘要: Protein kinase C (PKC) isoforms, a group of serine-threonine kinases, are important regulators in carcinogenesis. Numerous studies have demonstrated t ...

作者: Zhenghua Wu  1, Mengqi Jia  2, Wenjuan Zhao  3, Xucong Huang  4, Xinyi Yang  5, Dongxin Chen  6, Xijier Qiaolongbatu  7, Xiaojing Li  8, Jiaqi Wu  9, Feng Qian  10, Yuefen Lou  11, Guorong Fan  12 (Affiliations 1 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: wuzhenghua526@163.com. 2 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: 346852884@qq.com. 3 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: zhaowj@sjtu.edu.cn. 4 School of Pharmacy, Chongqing Medical University, Chongqing, 400016, PR China. Electronic address: 1109060643@qq.com. 5 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: Xinyi2017@sjtu.edu.cn. 6 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: 770512829doudou@sjtu.edu.cn. 7 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: 962689538@qq.com. 8 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: l_xiaojing@yeah.net. 9 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: wjq731030@126.com. 10 School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, PR China. Electronic address: fengqian@sjtu.edu.cn. 11 Department of Pharmacy, Shanghai Fourth People\'s Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200434, PR China. Electronic address: louyuefen@sina.cn. 12 Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, PR China. Electronic address: fanguorong@sjtu.edu.cn.)

出处: Journal of ethnopharmacology 2022 Vol.289 P115031

关键词: Idiopathic pulmonary fibrosis;Network pharmacology;Schisandra chinensis;Schisandrol A;TGF-β signaling pathway;UPLC-Q-TOF/MS.

摘要: Ethnopharmacological relevance: Schisandra chinensis decoction derived from the book of Waitai Miyao (Tao Wang, Tang dynasty) is often used in the tre ...

作者: Xiaofeng Zhu #  1   2   3   4   5, Yi Xu #  1   2, Lina Lu  6   7, Haidong Zou  8   9   10   11   12 (Affiliations 1 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 4 National Clinical Research Center for Eye Diseases, Shanghai, China. 5 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. 6 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. lulina781019@qq.com. 7 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lulina781019@qq.com. 8 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center/Shanghai Eye Hospital, Shanghai, China. zouhaidong@sjtu.edu.cn. 9 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zouhaidong@sjtu.edu.cn. 10 Shanghai Engineering Research Center of Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 11 National Clinical Research Center for Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 12 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn.)

出处: BMC health services research 2022 Vol.22 No.1 P160

关键词: Community health centers;Satisfaction;Telescreening;Vision-threatening diabetic retinopathy.

摘要: Background: The success of telescreening and the management of diabetic retinopathy (DR) in communities depends on stakeholder satisfaction, including ...

作者: Peng Li #  1, Zhiyong Ji #  1   2, Erlei Zhi  1, Yuxiang Zhang  1, Sha Han  1, Liangyu Zhao  1, Ruhui Tian  1, Huixing Chen  1, Yuhua Huang  1, Jing Zhang  3, Huirong Chen  1, Fujun Zhao  1, Zhi Zhou  4, Zheng Li  5, Chencheng Yao  6   7 (Affiliations 1 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. 2 State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211116, China. 3 The Reproductive Medicine Research Center, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510620, China. 4 School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. zhouzhi@shanghaitech.edu.cn. 5 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. lizhengboshi@sjtu.edu.cn. 6 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. yaochencheng@126.com. 7 School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. yaochencheng@126.com.)

出处: Reproductive biology and endocrinology : RB&E 2022 Vol.20 No.1 P21

关键词: MSH4;Male infertility;Meiosis;Non-obstructive azoospermia.

摘要: Background: Non-obstructive azoospermia (NOA) is one of the most severe type in male infertility, and the genetic causes of NOA with meiotic arrest re ...

作者: Xinran Qin  1, Haidong Zou  2   3   4   5   6 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zouhaidong@sjtu.edu.cn. 3 Shanghai Eye Diseases Prevention & Treatment Center, Shanghai Eye Hospital, Shanghai, China. zouhaidong@sjtu.edu.cn. 4 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 5 National Clinical Research Center for Eye Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn. 6 Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. zouhaidong@sjtu.edu.cn.)

出处: BMC ophthalmology 2022 Vol.22 No.1 P86

关键词: Blood-retina barrier;Diabetic retinopathy;Dysbiosis;Gut leakage;Inflammation;Lipopolysaccharides;Retinal glia.

摘要: Diabetes mellitus (DM) is a complex metabolic syndrome characterized by hyperglycemia. Diabetic retinopathy (DR) is the most common complication of DM ...

作者: Qing Liu #  1, Zhihong Zhu #  2, Wen Cai  3, Liu Yang  2, ShuangDi Li  4, Jiarong Zhang  5   6 (Affiliations 1 Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, 2699 Gaoke West Road, Shanghai, China. 2 Department of Obstetrics and Gynecology, Shanghai ZhongShan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China. 3 Department of Obstetrics and Gynecology, ShangHai General Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, China. 4 Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, 2699 Gaoke West Road, Shanghai, China. lishuangdi21@126.com. 5 Department of Obstetrics and Gynecology, Shanghai ZhongShan Hospital, Fudan University, 180 Fenglin Road, Shanghai, China. maggie1974@126.com. 6 Department of Obstetrics and Gynecology, ShangHai General Hospital, Shanghai Jiaotong University, 100 Haining Road, Shanghai, China. maggie1974@126.com.)

出处: Journal of translational medicine 2022 Vol.20 No.1 P81

关键词: Hypertriglyceridemia;Metabolism;OLTT;Prediction;Preeclampsia.

摘要: Background: Abnormal maternal lipid concentrations are associated with increased risk of preeclampsia. However, previous studies mainly focused on fas ...

作者: Qianqian Ju  1, Maorong Jiang  2, Wenxin Huang  3, Qingbo Yang  4, Zhenghong Luo  4, Hui Shi  1 (Affiliations 1 School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China. 2 Key Laboratory for Neuroregeneration, Medical College of Nantong University, Nantong, Jiangsu 226001, P.R. China. 3 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China. 4 Department of Thoracic Surgery, Shanghai Tenth People\'s Hospital, Shanghai 200072, P.R. China.)

出处: Oncology reports 2022 Vol.47 No.2 P29

关键词: CtBP2;TGIF;Wnt/β‑catenin;esophageal squamous cell carcinoma;invasion;migration;proliferation.

摘要: C‑terminal‑binding protein 2 (CtBP2), a transcriptional co‑repressor, plays a main role in tumorigenesis and in the development of multiple tumors. Tr ...

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