作者： Shunli Wu;Changcun Liu;Wenjuan Li;Chenxi Zhang;Dagui Chen;Can Xu;Li Su;Xiuhui Wang （Affiliations ¹ Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China. suli1020@shu.edu.cn. ² School of Medicine, Shanghai University, Shanghai, 200444, China. ³ School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China. ⁴ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. ⁵ First Affiliated Hospital of Soochow University, Suzhou, 215006, China. ⁶ Shengqiao Community Health Service Centre, Yuepu Town, Baoshan District, Shanghai, 200942, China. ⁷ Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China. canxudoc@126.com.）

出处： Journal of materials chemistry. B 2023

摘要： Nanomedicines have been widely used for cancer therapy, while controlling their activity for effective and safe treatment remains a big challenge. Her ...

作者： Xu Quan;Ying Xin;He-Ling Wang;Yingjie Sun;Chanchan Chen;Jiangying Zhang （Affiliations ¹ Department of Stomatology, Shanghai General Hospital, Shanghai, China. ² Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. ³ Department of Pathology, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. ⁴ Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway. ⁵ Xiangya School of Stomatology, Central South University, Changsha, Hunan, China. ⁶ Department of Stomatology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.）

出处： PeerJ 2023

关键词： Metabolic regulation;Oral cancer;Sirtuin.

摘要： Sirtuins (SIRTs 1-7) are a group of histone deacetylase enzymes with a wide range of enzyme activities that target a range of cellular proteins in the ...

作者： Qin Shi;Jing Yu;Deyue Liu;Fang Ren;Jiayi Wu;Kunwei Shen （Affiliations ¹ Department of Breast and Thyroid Surgery, Hangzhou Linping District Maternal and child Care Hospital, Hangzhou, China. ² Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China. ³ Department of Breast and Thyroid Surgery, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. ⁴ Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China. pinkscorpio@163.com. ⁵ Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China. kwshen@medmail.com.cn.）

出处： BMC cancer 2023

关键词： Breast cancer;Clinical outcome;Disease recurrence;Evolution;HER2-low.

摘要： Background: Novel antibody‒drug conjugates (ADC) have shown great efficacy in HER2-low advanced breast cancer. However, the clinical features of HER2- ...

作者： Xiaojun Zhou;Yuhan Qian;Liang Chen;Tao Li;Xin Sun;Xiaojun Ma;Jinwu Wang;Chuanglong He （Affiliations ¹ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China. ² Department of Joint Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan 528400, China. ³ Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. ⁴ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.）

出处： ACS nano 2023

关键词： biomimetic scaffold;bone microenvironment;bone regeneration;dual-factor delivery;tissue infiltration;vascularization.

摘要： The favorable microstructure and bioactivity of tissue-engineered bone scaffolds are closely associated with the regenerative efficacy of bone defects ...

作者： Yining Huang;Yixiong Yuan;Yujie Wang;Ziwen Hui;Xianwen Shang;Yanping Chen;Siran Zhang;Huan Liao;Yifan Chen;Mingguang He;Zhuoting Zhu;Wei Wang （Affiliations ¹ State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China (Y.H., Y.Y., Yanping Chen, S.Z., M.H., W.W.). ² Nanshan School, Guangzhou Medical University, China (Y.H.). ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China (Y.W.). ⁴ Zhongshan school of medicine, Sun Yat-sen University, Guangzhou, China (Z.H.). ⁵ Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia (X.S., M.H., Z.Z.). ⁶ Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China (X.S.). ⁷ Epigenetics and Neural Plasticity Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne (H.L.). ⁸ John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, United Kingdom (Yifan Chen).）

出处： Hypertension (Dallas, Tex. : 1979) 2023

关键词： blood pressure;cohort studies;optical coherence;retinal layers;retinal neurodegeneration.

摘要： Background: Hypertension might be a modifiable risk factor for neurodegeneration diseases. However, the associations between blood pressure (BP), arte ...

作者： Shibo Zhang;Cuiping Liu;Qian Wang;Haicong Zhou;Hao Wu;Junyi Zhuang;Yiyang Cao;Hongwei Shi;Jingfa Zhang;Jiao Wang （¹Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 99 Shang Da Road, Shanghai, China;²These authors contributed equally to this work and should be considered co-first authors.;³Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;⁴Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Heliyon 2023

关键词： Cross-modal plasticity;CRYAA;GJA8;PI3K/AKT/ERK signaling Pathway;Whisker tactile deprivation;Visual development

摘要： Deprivation of one sense can be followed by enhanced development of other senses via cross-modal plasticity mechanisms. To study the effect of whisker ...

作者： Jing Lu;Haoyu Wang;Wanyue Cao;Desheng Chen;Zeping He & Junming Xu （¹Department of General Surgery, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China）

出处： Human Cell 2023

关键词： m5C DNA methylation;lncRNA;Prognosis;HCC;Immunity

摘要： RNA modification serves as a kind of posttranscriptional modification. Besides N6-methyladenosine (m6A), 5-methylcytosine(m5C) is also an important RN ...

作者： Li Huang;Bin Hu;Jianbo Ni;Jianghong Wu;Weiliang Jiang;Congying Chen;Lijuan Yang;Yue Zeng;Rong Wan;Guoyong Hu;Xingpeng Wang （Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 100 Haining Road, Shanghai, 200080, Hongkou District, China）

出处： Journal of Experimental & Clinical Cancer Research 2023

摘要： This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-016-0301-7.

作者： Desheng Chen;Qi Zhu;Tiewen Li;Xuhui Fan;Yichao Lou;Yi Zhang;Kejie Huang;Hongcheng Sun （¹Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Institution for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;³Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴College of Information Science Electronic Engineering, Zhejiang University, Hangzhou, China）

出处： Frontiers in Genetics 2023

关键词： KLF4;hepatocellular carcinoma;biomarker;immune microenvironment;prognosis

摘要： Introduction: Although the molecular mechanisms of Krüpple-like factor 4 (KLF4) as a tumor suppressor in HCC tumorigenesis have been thoroughly examin ...

作者： Ying Zheng;Philip Schindler;Vasyl Druchkiv;Jan Schulz;Stephan Martin Spitzer & Christos Skevas （¹Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;²Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University, 100 Haining Road, 200080, Shanghai, China;³Department of Clínica Baviera, Valencia, Spain）

出处： BMC Ophthalmology 2023

关键词： 360° intraoperative laser retinopexy;Primary rhegmatogenous retinal detachment;Focal laser retinopexy

摘要： Background This study was to compare the outcomes of 360° intra-operative laser retinopexy (ILR) and focal laser retinopexy in treating patients with ...