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作者: Shunli Wu;Changcun Liu;Wenjuan Li;Chenxi Zhang;Dagui Chen;Can Xu;Li Su;Xiuhui Wang (Affiliations 1 Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China. suli1020@shu.edu.cn. 2 School of Medicine, Shanghai University, Shanghai, 200444, China. 3 School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China. 4 Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. 5 First Affiliated Hospital of Soochow University, Suzhou, 215006, China. 6 Shengqiao Community Health Service Centre, Yuepu Town, Baoshan District, Shanghai, 200942, China. 7 Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China. canxudoc@126.com.)

出处: Journal of materials chemistry. B 2023

摘要: Nanomedicines have been widely used for cancer therapy, while controlling their activity for effective and safe treatment remains a big challenge. Her ...

作者: Xu Quan;Ying Xin;He-Ling Wang;Yingjie Sun;Chanchan Chen;Jiangying Zhang (Affiliations 1 Department of Stomatology, Shanghai General Hospital, Shanghai, China. 2 Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. 3 Department of Pathology, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. 4 Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway. 5 Xiangya School of Stomatology, Central South University, Changsha, Hunan, China. 6 Department of Stomatology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.)

出处: PeerJ 2023

关键词: Metabolic regulation;Oral cancer;Sirtuin.

摘要: Sirtuins (SIRTs 1-7) are a group of histone deacetylase enzymes with a wide range of enzyme activities that target a range of cellular proteins in the ...

作者: Qin Shi;Jing Yu;Deyue Liu;Fang Ren;Jiayi Wu;Kunwei Shen (Affiliations 1 Department of Breast and Thyroid Surgery, Hangzhou Linping District Maternal and child Care Hospital, Hangzhou, China. 2 Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China. 3 Department of Breast and Thyroid Surgery, Shanghai General Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. 4 Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China. pinkscorpio@163.com. 5 Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China. kwshen@medmail.com.cn.)

出处: BMC cancer 2023

关键词: Breast cancer;Clinical outcome;Disease recurrence;Evolution;HER2-low.

摘要: Background: Novel antibody‒drug conjugates (ADC) have shown great efficacy in HER2-low advanced breast cancer. However, the clinical features of HER2- ...

作者: Xiaojun Zhou;Yuhan Qian;Liang Chen;Tao Li;Xin Sun;Xiaojun Ma;Jinwu Wang;Chuanglong He (Affiliations 1 State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China. 2 Department of Joint Surgery, Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan 528400, China. 3 Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China. 4 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.)

出处: ACS nano 2023

关键词: biomimetic scaffold;bone microenvironment;bone regeneration;dual-factor delivery;tissue infiltration;vascularization.

摘要: The favorable microstructure and bioactivity of tissue-engineered bone scaffolds are closely associated with the regenerative efficacy of bone defects ...

作者: Yining Huang;Yixiong Yuan;Yujie Wang;Ziwen Hui;Xianwen Shang;Yanping Chen;Siran Zhang;Huan Liao;Yifan Chen;Mingguang He;Zhuoting Zhu;Wei Wang (Affiliations 1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China (Y.H., Y.Y., Yanping Chen, S.Z., M.H., W.W.). 2 Nanshan School, Guangzhou Medical University, China (Y.H.). 3 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China (Y.W.). 4 Zhongshan school of medicine, Sun Yat-sen University, Guangzhou, China (Z.H.). 5 Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia (X.S., M.H., Z.Z.). 6 Department of Ophthalmology, Guangdong Academy of Medical Sciences, Guangdong Provincial People's Hospital, Guangzhou, China (X.S.). 7 Epigenetics and Neural Plasticity Laboratory, Florey Institute of Neuroscience and Mental Health, University of Melbourne (H.L.). 8 John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, United Kingdom (Yifan Chen).)

出处: Hypertension (Dallas, Tex. : 1979) 2023

关键词: blood pressure;cohort studies;optical coherence;retinal layers;retinal neurodegeneration.

摘要: Background: Hypertension might be a modifiable risk factor for neurodegeneration diseases. However, the associations between blood pressure (BP), arte ...

作者: Shibo Zhang;Cuiping Liu;Qian Wang;Haicong Zhou;Hao Wu;Junyi Zhuang;Yiyang Cao;Hongwei Shi;Jingfa Zhang;Jiao Wang (1Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, 99 Shang Da Road, Shanghai, China;2These authors contributed equally to this work and should be considered co-first authors.;3Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;4Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China)

出处: Heliyon 2023

关键词: Cross-modal plasticity;CRYAA;GJA8;PI3K/AKT/ERK signaling Pathway;Whisker tactile deprivation;Visual development

摘要: Deprivation of one sense can be followed by enhanced development of other senses via cross-modal plasticity mechanisms. To study the effect of whisker ...

作者: Jing Lu;Haoyu Wang;Wanyue Cao;Desheng Chen;Zeping He & Junming Xu (1Department of General Surgery, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 200080, China)

出处: Human Cell 2023

关键词: m5C DNA methylation;lncRNA;Prognosis;HCC;Immunity

摘要: RNA modification serves as a kind of posttranscriptional modification. Besides N6-methyladenosine (m6A), 5-methylcytosine(m5C) is also an important RN ...

作者: Li Huang;Bin Hu;Jianbo Ni;Jianghong Wu;Weiliang Jiang;Congying Chen;Lijuan Yang;Yue Zeng;Rong Wan;Guoyong Hu;Xingpeng Wang (Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, 100 Haining Road, Shanghai, 200080, Hongkou District, China)

出处: Journal of Experimental & Clinical Cancer Research 2023

摘要: This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-016-0301-7.

作者: Desheng Chen;Qi Zhu;Tiewen Li;Xuhui Fan;Yichao Lou;Yi Zhang;Kejie Huang;Hongcheng Sun (1Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;2Institution for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;3Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;4College of Information Science Electronic Engineering, Zhejiang University, Hangzhou, China)

出处: Frontiers in Genetics 2023

关键词: KLF4;hepatocellular carcinoma;biomarker;immune microenvironment;prognosis

摘要: Introduction: Although the molecular mechanisms of Krüpple-like factor 4 (KLF4) as a tumor suppressor in HCC tumorigenesis have been thoroughly examin ...

作者: Ying Zheng;Philip Schindler;Vasyl Druchkiv;Jan Schulz;Stephan Martin Spitzer & Christos Skevas (1Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;2Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiaotong University, 100 Haining Road, 200080, Shanghai, China;3Department of Clínica Baviera, Valencia, Spain)

出处: BMC Ophthalmology 2023

关键词: 360° intraoperative laser retinopexy;Primary rhegmatogenous retinal detachment;Focal laser retinopexy

摘要: Background This study was to compare the outcomes of 360° intra-operative laser retinopexy (ILR) and focal laser retinopexy in treating patients with ...

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