作者： Zhiwen Deng¹²;Liangyu Zhao¹³⁴;Sha Li¹²;Xiaoyang Chen¹²;Xiaohan Ling¹²;Jiajun Zheng¹²;Kunkun Yu¹²;Jing Xu¹;Chencheng Yao³;Sha Han³;Jiayi Liang¹;Huimin Feng¹;Lanlan Wu¹;Peng Li³;Ruhui Tian³;Tao Jing³⁵;Yuxin Tang⁴;Yingbo Dai⁴;Minbo Yan⁴;Chenchen Wang⁶CA1;Zheng Li³CA2;null;Zhi Zhou¹²CA3 （¹School of Life Science and Technology, ShanghaiTech University, Shanghai, China;²Shanghai Clinical Research and Trial Center, Shanghai, China;³Department of Andrology, the Center for Men’s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴Department of Urology, Department of Interventional Medicine, Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China;⁵Department of Andrology, the Affiliated Hospital of Qingdao University, Qingdao, China;⁶Shanghai Advanced Research Institute, Stem Cell and Reproductive Biology Laboratory, Chinese Academy of Sciences, Shanghai, China）

出处： Nature Aging 2024

摘要： Age-related changes in testicular function can impact health and well-being. The mechanisms underlying age-related testicular dysfunction, such as lat ...

作者： Bin Zhang,‡^ab and Rui Yang,‡^bc and Hongwei Yu,^e and Yamin Peng,^b and Haoyu Huang,^b and Meera Moydeen Abdul Hameed, ^d and Han Wang, ^e and Guixiang Zhang,*^a and Mohamed EL-Newehy, ^d and Mingwu Shen, ^b and Xiangyang Shi *^bf  and and Shaojun Peng*^g   （* Corresponding authors ^a Department of Radiology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China E-mail: Guixiangzhang@sina.com ^b State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China E-mail: xshi@dhu.edu.cn ^c Medical School, Kunming University of Science and Technology, Kunming 650500, China ^d Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia ^e Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China ^f CQM-Centro de Quimica da Madeira, Universidade da Madeira, Funchal 9020-105, Portugal ^g Center for Biological Science and Technology & College of Arts and Sciences, Beijing Normal University, Zhuhai 519087, China E-mail: 91122024006@bnu.edu.cn）

出处： Biomaterials Science 2024

摘要： Developing effective nanomedicines to cross the blood–brain barrier (BBB) for efficient glioma theranostics is still considered to be a challenging ta ...

作者： Te Liu  ¹, Yichao Wen  ¹, Zeyu Cui  ¹, Haiyang Chen  ¹, Jiajia Lin  ¹, Jianghong Xu  ², Danping Chen  ², Ying Zhu  ², Zhihua Yu  ¹, Chunxia Wang  ³, Bimeng Zhang  ⁴ （Affiliations ¹ Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. ² Department of Gynaecology, Jingan Hospital of Traditional Chinese Medicine, Shanghai, China. ³ Department of Reproductive Medicine, Henan Province Hospital of Traditional Chinese Medicine, Henan, China. ⁴ Department of Acupuncture, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Cell proliferation 2024

摘要： The in-depth mechanisms of microRNA regulation of premature ovarian failure (POF) remain unclear. Crispr-cas9 technology was used to construct transge ...

作者： Dongning Su  ¹, Zhijin Zhang  ¹, Zhe Zhang  ¹, Sujun Zheng  ¹, Tingyan Yao  ¹, Yi Dong  ¹, Wanlin Zhu  ¹, Ning Wei  ¹, Yue Suo  ¹, Xinyao Liu  ¹, Huiqing Zhao  ¹, Zhan Wang  ¹, Huizi Ma  ¹, Wei Li  ¹, Junhong Zhou  ¹, Joyce S T Lam  ¹, Tao Wu  ¹, Petr Dusek  ¹, A Jon Stoessl  ¹, Xiaoping Wang  ¹, Jing Jing  ¹, Tao Feng  ¹ （Affiliation ¹ From the Department of Neurology (D.S., Zhijin Zhang, H.Z., Z.W., H.M., W.L., T.W., J.J., T.F.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (D.S., Zhijin Zhang, Zhe Zhang, W.Z., N.W., Y.S., X.L., H.Z., Z.W., H.M., W.L., T.W., J.J., T.F.); Tiantan Neuroimaging Center of Excellence (Zhe Zhang, W.Z., N.W., Y.S., X.L., J.J.), and Department of Hepatology (S.Z.), Beijing Youan Hospital, Capital Medical University; Department of Neurology (T.Y.), Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders; Senior Department of Hepatology (Y.D.), the Fifth Medical Center of PLA General Hospital, Beijing, China; Hinda and Arthur Marcus Institute for Aging Research (J.Z.), Hebrew SeniorLife, Roslindale; Harvard Medical School (J.Z.), Boston, MA; Pacific Parkinson's Research Centre (J.S.T.L., A.J.S.), Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada; Department of Neurology and Centre of Clinical Neuroscience (P.D.), First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Division of Neurology (A.J.S.), Department of Medicine, University of British Columbia, Vancouver, Canada; and Department of Neurology (X.W.), Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China.）

出处： Neurology 2024

摘要： Background and objectives: Noninvasive and accurate biomarkers of neurologic Wilson disease (NWD), a rare inherited disorder, could reduce diagnostic ...

作者： Huidan Li  ¹, Xiaorui Wang  ¹, Jing Zhu  ², Bingzhe Yang  ³, Jiatao Lou  ¹ （Affiliations ¹ Clinical Laboratory Medicine Center, Shanghai General Hospital, Shanghai, China. ² Clinical Laboratory Medicine Center, Jiading Branch of Shanghai General Hospital, Shanghai, China. ³ School of Medicine, Shanghai Jiao Tong University, Shanghai, China.）

出处： Biomolecules & biomedicine 2024

摘要： Psoriasis is a globally prevalent chronic inflammatory skin disease. This study aimed to scrutinize the hub genes related to inflammation and potentia ...

作者： Huan Yu ^{#  1}, Bingqiao Shen ^{#  1   2}, Ruiqi Han  ¹, Yang Zhang  ¹, Shushu Xu  ¹, Yumeng Zhang  ¹, Yanzhi Guo  ¹, Ping Huang ^{#  3}, Shouyue Huang ^{#  4}, Yisheng Zhong ^{#  5} （Affiliations ¹ Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai, 200025, China. ² Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China. ³ Shanghai Key Laboratory for Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai, 200025, China. pinghpingh@126.com. ⁴ Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai, 200025, China. yachtjj@hotmail.com. ⁵ Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, 197 Ruijin Er Road, Shanghai, 200025, China. yszhong68@126.com.）

出处： Inflammation and regeneration 2024

关键词： CX3CL1-CX3CR1 axis;Microglia;Optic nerve trauma;Retinal ganglion cells.

摘要： Background: The chemokine CX3CL1 has been reported to play an important role in optic nerve protection, but the underlying mechanism is still unclear. ...

作者： Haihua Huang  ¹, Zhentian Kai  ², Yuchen Wang  ¹, Xiaomiao Zhang  ¹, Jin Wang  ¹, Wei Zhang  ¹, Qian Xue  ¹, Hang Zhang  ¹, Hansong Jin  ¹, Peize Meng  ¹, Shuilong Zhang  ², Yueyue Yang  ², Honghua Yang  ², Wanning Liang  ², Guangbing Zha  ², Peng Luo  ², Yan Xu  ², Weiwei Shi  ², Zheng Ruan  ¹ （Affiliations ¹ Department of Thoracic Surgery, Shanghai First People's Hospital, Shanghai, China. ² Department of research and Development, Zhejiang Shaoxing Topgen Biomedical Technology Co., Ltd., Shanghai, China.）

出处： Cancer medicine 2024

关键词： biomarkers;biotechnology;genomics;lung cancer;molecular diagnosis.

摘要： Circulating tumor DNA (ctDNA) has been widely used as a minimally invasive biomarker in clinical routine. However, a number of factors such as panel d ...

作者： Dan Wang¹;Dan Zhu¹;Min Xia¹;Xiaoying Wang¹;Ni Zou¹CA1 （¹Department of Infection Prevention and Control, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Heliyon 2024

关键词： COVID-19;SARS-CoV-2;Omicron;Healthcare worker;Epidemiology;Risk factor;Vaccine effectiveness

摘要： Background The COVID-19 pandemic has exposed healthcare workers (HCWs) to serious risk of infection. The aims of our study were to investigate the epi ...

作者： Xinyi Zhang  ¹, Yun Zou  ², Yuqi Liu  ², Yumeng Cao  ², Jiali Zhu  ², Jianhai Zhang  ², Xia Chen  ², Rui Zhang  ³, Jinbao Li  ⁴ （Affiliations ¹ Department of Anesthesiology, Weifang Medical University, Weifang, China; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. ² Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. ³ Department of Anesthesiology, Weifang Medical University, Weifang, China. Electronic address: zhangrui@wfmc.edu.cn. ⁴ Department of Anesthesiology, Weifang Medical University, Weifang, China; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address: lijinbaoshanghai@163.com.）

出处： Molecular immunology 2024

作者： Chun Bi¹1;Gang Yin¹2;Lei Cao¹3;Haodong Lin¹CA4;Jiandong Wang¹CA5 （¹Department of Orthopedics Trauma, Trauma Center, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, 650 Xin Songjiang Road, Shanghai, 201620, PR China）

出处： Journal of Orthopaedics 2024

摘要： Objective Surgical intervention and fixation is the recognized measurement to treat pubic symphysis diastasis caused by high-energy trauma. The purpos ...