作者： Xin Zhou  ¹, Yuqing Zhao  ², Shixue Huang  ¹, Haoming Shu  ^{3   4}, Yinuo Zhang  ¹, Haiyuan Yang  ^{3   4}, Yilong Ren  ^{3   4}, Xuhui Zhou  ^{1   4}, Wei Liu  ¹, Tengfei Song  ¹, Jianquan Zhao  ¹, Jun Ma  ^{3   4} （Affiliations ¹ Department of Orthopedics, Changzheng Hospital, The Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. ² Department of Neurosurgery, Changzheng Hospital, The Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. ³ Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁴ Translational Research Centre of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.）

出处： International journal of biological sciences 2025

关键词： GPX4;TRIM32;autophagic degradation;neuronal ferroptosis;ubiquitination.

摘要： Ferroptosis, characterized by iron-dependent phospholipid peroxidation, is recognized as one of the cell death pathways activated following spinal cor ...

作者： Yi Wang ^{#  1   2}, Guihua Chen ^{#  2}, Deng Li  ³ （Affiliations ¹ Department of Urology, Affiliated Hospital of Nantong University, No.20 West Temple Road, Nantong, 226001, China. ² Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.85 Wujin Road, Shanghai, 200080, China. ³ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.85 Wujin Road, Shanghai, 200080, China. lideng1991@hotmail.com.）

出处： Biology direct 2025

作者： Fan Ye ^{#  1   2}, Ziran Zhang ^{#  1}, Lianjun Shi ^{#  1}, Shuting Lu  ¹, Xiumiao Li  ¹, Wan Mu  ^{2   3}, Qin Jiang  ⁴, Biao Yan  ⁵ （Affiliations ¹ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China. ⁴ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China. jiangqin710@126.com. ⁵ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yanbiao@sjtu.edu.cn.）

出处： Cell death & disease 2025

摘要： Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in seve ...

作者： Lingzhou Zhao ^{#  1}, Jiali Gong ^{#  1}, Sisi Liao ^{#  1}, Wenhua Huang  ², Jinhua Zhao  ³, Yan Xing  ⁴ （Affiliations ¹ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou District, No. 100, Haining Road, Shanghai, 200080, China. ² Nanomab Technology Limited, No. 333, North Chengdu Road, Jingan District, Shanghai, 200041, China. ³ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou District, No. 100, Haining Road, Shanghai, 200080, China. zhaojinhua1963@126.com. ⁴ Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou District, No. 100, Haining Road, Shanghai, 200080, China. xy.1@163.com.）

出处： Cancer imaging : the official publication of the International Cancer Imaging Society 2025

关键词： Nanobody;Non-small-cell lung cancer;PET imaging;Programmed death ligand-1.

摘要： Background: Programmed cell death 1/programmed death ligand-1 (PD-L1)-based immune checkpoint blockade is an effective treatment approach for non-smal ...

作者： Ye Liu  ¹, Xi-Xi Wang  ¹, Xu-Jun Wang  ², Min-Min Yin  ³, Mo-Yao Tan  ⁴, Chang-Peng Wang  ¹, Tie-Nan Feng  ⁵, Jie Liu  ⁶, Yu Wang  ¹, Xuan Li  ¹, Si-Jia Peng  ¹, Xiao-Jin Zhang  ¹, Xiao-Ying Zhu  ¹, Ya Feng  ⁷, Eng-King Tan  ⁸, Yun-Cheng Wu  ⁹ （Affiliations ¹ Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. ² SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China. ³ Department of Special Education, Faculty of Education, Hangzhou Normal University, China. ⁴ Chinese Academy of Speech and Hearing Rehabilitation Science and ICF Application, East China Normal University, China. ⁵ Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, China. ⁶ Department of Rehabilitation, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. ⁷ Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. Electronic address: feng_ya1989@126.com. ⁸ Department of Neurology, Singapore General Hospital Campus, National Neuroscience Institute, Singapore. Electronic address: tan.eng.king@singhealth.com.sg. ⁹ Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. Electronic address: yunchw@medmail.com.cn.）

出处： Parkinsonism & related disorders 2025

关键词： Acoustic parameter;Cognitive impairment;Early diagnosis;Parkinson's disease;Prosody.

摘要： Background: Acoustic prosodic analysis is a novel approach that can be used to identify patients with mild cognitive impairment (MCI) and dementia in ...

作者： Q I Lv  ¹, Gangmin Wang  ², Y I Hong  ¹, Tianyi Zhu  ¹, Shuang Qin  ¹, Saifei Sun  ¹, Yuting Wang  ¹, Yaohua Liu  ¹, Qing Zhang  ¹, Chunhui Ma  ³, Peijun Wang  ¹ （Affiliations ¹ Imaging Department, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. ² Urology Department, Huashan Hospital, Fudan University, Shanghai, 200040, China. ³ Orthopedic Department, Shanghai General Hospital of Shanghai Jiaotong University, Shanghai, 200080, China.）

出处： Oncology research 2025

关键词： Circular RNA circAGAP1;MiR-149-5p;MiR-15a-5p;MiR-455-5p;Renal cell carcinoma;Sunitinib resistance.

摘要： Background: Sunitinib resistance is a major challenge in advanced renal cell carcinoma (RCC). Clinically, elucidating the underlying mechanisms and de ...

作者： Jingjing Xiang  ¹, Liangliang Cai  ², Qin Wang  ², Yonghong Zhu  ¹, Yong Han  ³ （Affiliations ¹ Department of Pharmacy, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, China. ² Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, China. ³ Department of Oncology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.）

出处： Frontiers in chemistry 2025

关键词： degradation products;liquid chromatography;method development;method validation;related substances;selpercatinib.

摘要： Background: Selpercatinib, a selective RET kinase inhibitor, is approved for treating various cancers with RET gene mutations such as RET-rearranged t ...

作者： Hang Zhang ^{#  1}, Ruoyu Zhang ^{#  2}, Min Yu  ³, Zhongxiang Yuan  ³, Dewei Qian  ³, Wen Chen  ², Fuhua Huang  ², Xin Chen  ⁴, Xiaodi Wang  ⁵ （Affiliations ¹ Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. ³ Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. stevecx@njmu.edu.cn. ⁵ Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. theodorewang@126.com.）

出处： BMC cardiovascular disorders 2025

关键词： Acute aortic dissection;Aortic arch;Frozen elephant trunk;Hybrid;Total arch replacement.

摘要： Background: The aim of this study was to investigate whether the hybrid technique yields superior outcomes in comparison with the total arch replaceme ...

作者： Haitao Mei ^{#  1   2   3}, Qingshan Luo ^{#  2}, Junyong Weng ^{#  3   4}, Jialing Hao  ², Jinfeng Cai  ², Runkai Zhou  ², Ce Bian  ³, Yingzi Ye  ⁵, Shengzheng Luo  ⁶, Yugang Wen  ⁷ （Affiliations ¹ Department of Gastrointestinal Surgery, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Road, Shanghai, 200071, China. ² Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Shanghai, 200080, China. ³ Department of Colorectal Surgery, Changzheng Hospital, Navy Medical University, 415 Fengyang Road, Shanghai, 200003, China. ⁴ Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China. ⁵ Department of Infectious Diseases, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. yeyingzi1502@sina.com. ⁶ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Shanghai, 200080, China. luoshengzheng2007@163.com. ⁷ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Shanghai, 200080, China. wenyg1502@hotmail.com.）

出处： Cellular & molecular biology letters 2025

作者： Zhibo Shao  ^{1   2}, Hengyu Ren  ^{1   2}, Xuliren Wang  ^{1   2}, Qi Zhang  ^{1   2}, Jingyan Xue  ^{1   2}, Yayun Chi  ³, Bingqiu Xiu  ^{1   2}, Jiong Wu  ^{1   2} （Affiliations ¹ Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, China. ² Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. ³ Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.）

出处： International journal of medical sciences 2025

摘要： RAC1, a member of the Rho family GTPases, has been implicated in various cancers, yet its pan-cancer landscape and role in the tumor immune microenvir ...