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作者: Xin Zhou 1, Yuqing Zhao 2, Shixue Huang 1, Haoming Shu 3 4, Yinuo Zhang 1, Haiyuan Yang 3 4, Yilong Ren 3 4, Xuhui Zhou 1 4, Wei Liu 1, Tengfei Song 1, Jianquan Zhao 1, Jun Ma 3 4 (Affiliations 1 Department of Orthopedics, Changzheng Hospital, The Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. 2 Department of Neurosurgery, Changzheng Hospital, The Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. 3 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 4 Translational Research Centre of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.)
出处: International journal of biological sciences 2025
关键词: GPX4;TRIM32;autophagic degradation;neuronal ferroptosis;ubiquitination.
摘要: Ferroptosis, characterized by iron-dependent phospholipid peroxidation, is recognized as one of the cell death pathways activated following spinal cor ...
作者: Yi Wang # 1 2, Guihua Chen # 2, Deng Li 3 (Affiliations 1 Department of Urology, Affiliated Hospital of Nantong University, No.20 West Temple Road, Nantong, 226001, China. 2 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.85 Wujin Road, Shanghai, 200080, China. 3 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.85 Wujin Road, Shanghai, 200080, China. lideng1991@hotmail.com.)
出处: Biology direct 2025
作者: Fan Ye # 1 2, Ziran Zhang # 1, Lianjun Shi # 1, Shuting Lu 1, Xiumiao Li 1, Wan Mu 2 3, Qin Jiang 4, Biao Yan 5 (Affiliations 1 The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China. 4 The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China. jiangqin710@126.com. 5 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yanbiao@sjtu.edu.cn.)
出处: Cell death & disease 2025
摘要: Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in seve ...
作者: Lingzhou Zhao # 1, Jiali Gong # 1, Sisi Liao # 1, Wenhua Huang 2, Jinhua Zhao 3, Yan Xing 4 (Affiliations 1 Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou District, No. 100, Haining Road, Shanghai, 200080, China. 2 Nanomab Technology Limited, No. 333, North Chengdu Road, Jingan District, Shanghai, 200041, China. 3 Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou District, No. 100, Haining Road, Shanghai, 200080, China. zhaojinhua1963@126.com. 4 Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou District, No. 100, Haining Road, Shanghai, 200080, China. xy.1@163.com.)
出处: Cancer imaging : the official publication of the International Cancer Imaging Society 2025
关键词: Nanobody;Non-small-cell lung cancer;PET imaging;Programmed death ligand-1.
摘要: Background: Programmed cell death 1/programmed death ligand-1 (PD-L1)-based immune checkpoint blockade is an effective treatment approach for non-smal ...
作者: Ye Liu 1, Xi-Xi Wang 1, Xu-Jun Wang 2, Min-Min Yin 3, Mo-Yao Tan 4, Chang-Peng Wang 1, Tie-Nan Feng 5, Jie Liu 6, Yu Wang 1, Xuan Li 1, Si-Jia Peng 1, Xiao-Jin Zhang 1, Xiao-Ying Zhu 1, Ya Feng 7, Eng-King Tan 8, Yun-Cheng Wu 9 (Affiliations 1 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. 2 SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China. 3 Department of Special Education, Faculty of Education, Hangzhou Normal University, China. 4 Chinese Academy of Speech and Hearing Rehabilitation Science and ICF Application, East China Normal University, China. 5 Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, China. 6 Department of Rehabilitation, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. 7 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. Electronic address: feng_ya1989@126.com. 8 Department of Neurology, Singapore General Hospital Campus, National Neuroscience Institute, Singapore. Electronic address: tan.eng.king@singhealth.com.sg. 9 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. Electronic address: yunchw@medmail.com.cn.)
出处: Parkinsonism & related disorders 2025
关键词: Acoustic parameter;Cognitive impairment;Early diagnosis;Parkinson's disease;Prosody.
摘要: Background: Acoustic prosodic analysis is a novel approach that can be used to identify patients with mild cognitive impairment (MCI) and dementia in ...
作者: Q I Lv 1, Gangmin Wang 2, Y I Hong 1, Tianyi Zhu 1, Shuang Qin 1, Saifei Sun 1, Yuting Wang 1, Yaohua Liu 1, Qing Zhang 1, Chunhui Ma 3, Peijun Wang 1 (Affiliations 1 Imaging Department, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. 2 Urology Department, Huashan Hospital, Fudan University, Shanghai, 200040, China. 3 Orthopedic Department, Shanghai General Hospital of Shanghai Jiaotong University, Shanghai, 200080, China.)
出处: Oncology research 2025
关键词: Circular RNA circAGAP1;MiR-149-5p;MiR-15a-5p;MiR-455-5p;Renal cell carcinoma;Sunitinib resistance.
摘要: Background: Sunitinib resistance is a major challenge in advanced renal cell carcinoma (RCC). Clinically, elucidating the underlying mechanisms and de ...
作者: Jingjing Xiang 1, Liangliang Cai 2, Qin Wang 2, Yonghong Zhu 1, Yong Han 3 (Affiliations 1 Department of Pharmacy, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, China. 2 Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, China. 3 Department of Oncology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.)
出处: Frontiers in chemistry 2025
关键词: degradation products;liquid chromatography;method development;method validation;related substances;selpercatinib.
摘要: Background: Selpercatinib, a selective RET kinase inhibitor, is approved for treating various cancers with RET gene mutations such as RET-rearranged t ...
作者: Hang Zhang # 1, Ruoyu Zhang # 2, Min Yu 3, Zhongxiang Yuan 3, Dewei Qian 3, Wen Chen 2, Fuhua Huang 2, Xin Chen 4, Xiaodi Wang 5 (Affiliations 1 Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. 3 Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. stevecx@njmu.edu.cn. 5 Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. theodorewang@126.com.)
出处: BMC cardiovascular disorders 2025
关键词: Acute aortic dissection;Aortic arch;Frozen elephant trunk;Hybrid;Total arch replacement.
摘要: Background: The aim of this study was to investigate whether the hybrid technique yields superior outcomes in comparison with the total arch replaceme ...
作者: Haitao Mei # 1 2 3, Qingshan Luo # 2, Junyong Weng # 3 4, Jialing Hao 2, Jinfeng Cai 2, Runkai Zhou 2, Ce Bian 3, Yingzi Ye 5, Shengzheng Luo 6, Yugang Wen 7 (Affiliations 1 Department of Gastrointestinal Surgery, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Road, Shanghai, 200071, China. 2 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Shanghai, 200080, China. 3 Department of Colorectal Surgery, Changzheng Hospital, Navy Medical University, 415 Fengyang Road, Shanghai, 200003, China. 4 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China. 5 Department of Infectious Diseases, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. yeyingzi1502@sina.com. 6 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Shanghai, 200080, China. luoshengzheng2007@163.com. 7 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Shanghai, 200080, China. wenyg1502@hotmail.com.)
出处: Cellular & molecular biology letters 2025
作者: Zhibo Shao 1 2, Hengyu Ren 1 2, Xuliren Wang 1 2, Qi Zhang 1 2, Jingyan Xue 1 2, Yayun Chi 3, Bingqiu Xiu 1 2, Jiong Wu 1 2 (Affiliations 1 Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, China. 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. 3 Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.)
出处: International journal of medical sciences 2025
摘要: RAC1, a member of the Rho family GTPases, has been implicated in various cancers, yet its pan-cancer landscape and role in the tumor immune microenvir ...
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