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作者: Xin Zhou  1, Yuqing Zhao  2, Shixue Huang  1, Haoming Shu  3   4, Yinuo Zhang  1, Haiyuan Yang  3   4, Yilong Ren  3   4, Xuhui Zhou  1   4, Wei Liu  1, Tengfei Song  1, Jianquan Zhao  1, Jun Ma  3   4 (Affiliations 1 Department of Orthopedics, Changzheng Hospital, The Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. 2 Department of Neurosurgery, Changzheng Hospital, The Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. 3 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 4 Translational Research Centre of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.)

出处: International journal of biological sciences 2025

关键词: GPX4;TRIM32;autophagic degradation;neuronal ferroptosis;ubiquitination.

摘要: Ferroptosis, characterized by iron-dependent phospholipid peroxidation, is recognized as one of the cell death pathways activated following spinal cor ...

作者: Yi Wang #  1   2, Guihua Chen #  2, Deng Li  3 (Affiliations 1 Department of Urology, Affiliated Hospital of Nantong University, No.20 West Temple Road, Nantong, 226001, China. 2 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.85 Wujin Road, Shanghai, 200080, China. 3 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.85 Wujin Road, Shanghai, 200080, China. lideng1991@hotmail.com.)

出处: Biology direct 2025

作者: Fan Ye #  1   2, Ziran Zhang #  1, Lianjun Shi #  1, Shuting Lu  1, Xiumiao Li  1, Wan Mu  2   3, Qin Jiang  4, Biao Yan  5 (Affiliations 1 The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China. 4 The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, China. jiangqin710@126.com. 5 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yanbiao@sjtu.edu.cn.)

出处: Cell death & disease 2025

摘要: Lymphangiogenesis is vital for tissue fluid homeostasis, immune function, and lipid absorption. Abnormal lymphangiogenesis has been implicated in seve ...

作者: Lingzhou Zhao #  1, Jiali Gong #  1, Sisi Liao #  1, Wenhua Huang  2, Jinhua Zhao  3, Yan Xing  4 (Affiliations 1 Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou District, No. 100, Haining Road, Shanghai, 200080, China. 2 Nanomab Technology Limited, No. 333, North Chengdu Road, Jingan District, Shanghai, 200041, China. 3 Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou District, No. 100, Haining Road, Shanghai, 200080, China. zhaojinhua1963@126.com. 4 Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou District, No. 100, Haining Road, Shanghai, 200080, China. xy.1@163.com.)

出处: Cancer imaging : the official publication of the International Cancer Imaging Society 2025

关键词: Nanobody;Non-small-cell lung cancer;PET imaging;Programmed death ligand-1.

摘要: Background: Programmed cell death 1/programmed death ligand-1 (PD-L1)-based immune checkpoint blockade is an effective treatment approach for non-smal ...

作者: Ye Liu  1, Xi-Xi Wang  1, Xu-Jun Wang  2, Min-Min Yin  3, Mo-Yao Tan  4, Chang-Peng Wang  1, Tie-Nan Feng  5, Jie Liu  6, Yu Wang  1, Xuan Li  1, Si-Jia Peng  1, Xiao-Jin Zhang  1, Xiao-Ying Zhu  1, Ya Feng  7, Eng-King Tan  8, Yun-Cheng Wu  9 (Affiliations 1 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. 2 SJTU-Yale Joint Center for Biostatistics and Data Science, Shanghai Jiao Tong University, Shanghai, China. 3 Department of Special Education, Faculty of Education, Hangzhou Normal University, China. 4 Chinese Academy of Speech and Hearing Rehabilitation Science and ICF Application, East China Normal University, China. 5 Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, China. 6 Department of Rehabilitation, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. 7 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. Electronic address: feng_ya1989@126.com. 8 Department of Neurology, Singapore General Hospital Campus, National Neuroscience Institute, Singapore. Electronic address: tan.eng.king@singhealth.com.sg. 9 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, China. Electronic address: yunchw@medmail.com.cn.)

出处: Parkinsonism & related disorders 2025

关键词: Acoustic parameter;Cognitive impairment;Early diagnosis;Parkinson's disease;Prosody.

摘要: Background: Acoustic prosodic analysis is a novel approach that can be used to identify patients with mild cognitive impairment (MCI) and dementia in ...

作者: Q I Lv  1, Gangmin Wang  2, Y I Hong  1, Tianyi Zhu  1, Shuang Qin  1, Saifei Sun  1, Yuting Wang  1, Yaohua Liu  1, Qing Zhang  1, Chunhui Ma  3, Peijun Wang  1 (Affiliations 1 Imaging Department, Tongji Hospital, Tongji University School of Medicine, Shanghai, 200065, China. 2 Urology Department, Huashan Hospital, Fudan University, Shanghai, 200040, China. 3 Orthopedic Department, Shanghai General Hospital of Shanghai Jiaotong University, Shanghai, 200080, China.)

出处: Oncology research 2025

关键词: Circular RNA circAGAP1;MiR-149-5p;MiR-15a-5p;MiR-455-5p;Renal cell carcinoma;Sunitinib resistance.

摘要: Background: Sunitinib resistance is a major challenge in advanced renal cell carcinoma (RCC). Clinically, elucidating the underlying mechanisms and de ...

作者: Jingjing Xiang  1, Liangliang Cai  2, Qin Wang  2, Yonghong Zhu  1, Yong Han  3 (Affiliations 1 Department of Pharmacy, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Nantong, China. 2 Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, China. 3 Department of Oncology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.)

出处: Frontiers in chemistry 2025

关键词: degradation products;liquid chromatography;method development;method validation;related substances;selpercatinib.

摘要: Background: Selpercatinib, a selective RET kinase inhibitor, is approved for treating various cancers with RET gene mutations such as RET-rearranged t ...

作者: Hang Zhang #  1, Ruoyu Zhang #  2, Min Yu  3, Zhongxiang Yuan  3, Dewei Qian  3, Wen Chen  2, Fuhua Huang  2, Xin Chen  4, Xiaodi Wang  5 (Affiliations 1 Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. 3 Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. stevecx@njmu.edu.cn. 5 Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. theodorewang@126.com.)

出处: BMC cardiovascular disorders 2025

关键词: Acute aortic dissection;Aortic arch;Frozen elephant trunk;Hybrid;Total arch replacement.

摘要: Background: The aim of this study was to investigate whether the hybrid technique yields superior outcomes in comparison with the total arch replaceme ...

作者: Haitao Mei #  1   2   3, Qingshan Luo #  2, Junyong Weng #  3   4, Jialing Hao  2, Jinfeng Cai  2, Runkai Zhou  2, Ce Bian  3, Yingzi Ye  5, Shengzheng Luo  6, Yugang Wen  7 (Affiliations 1 Department of Gastrointestinal Surgery, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Road, Shanghai, 200071, China. 2 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Shanghai, 200080, China. 3 Department of Colorectal Surgery, Changzheng Hospital, Navy Medical University, 415 Fengyang Road, Shanghai, 200003, China. 4 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, China. 5 Department of Infectious Diseases, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. yeyingzi1502@sina.com. 6 Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Shanghai, 200080, China. luoshengzheng2007@163.com. 7 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Shanghai, 200080, China. wenyg1502@hotmail.com.)

出处: Cellular & molecular biology letters 2025

作者: Zhibo Shao  1   2, Hengyu Ren  1   2, Xuliren Wang  1   2, Qi Zhang  1   2, Jingyan Xue  1   2, Yayun Chi  3, Bingqiu Xiu  1   2, Jiong Wu  1   2 (Affiliations 1 Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai 200032, China. 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. 3 Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.)

出处: International journal of medical sciences 2025

摘要: RAC1, a member of the Rho family GTPases, has been implicated in various cancers, yet its pan-cancer landscape and role in the tumor immune microenvir ...

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