作者： Rui Guo  ^{1   2}, Biao Ding  ³, Kaiqin Hu  ^{1   2}, Kai Wang  ^{1   2}, Dongdong Tang  ², Xuegu Wang  ³, Junpei Sun  ³, KuoKuo Li  ^{1   2}, Huiru Cheng  ^{1   2}, Chuan Xu  ², Miao Sun  ⁴, Likui Lu  ², Mingxi Liu  ⁵, Yunxia Cao  ^{1   2}, Xiaoyu Yang  ⁶, Xiaojin He  ^{1   7} （Affiliations ¹ NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui, China. ² Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. ³ Department of Obstetrics and Gynecology, Reproductive Medicine Center, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China. ⁴ Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou, China. ⁵ State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China. ⁶ State Key Laboratory of Reproductive Medicine, The Center for Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. ⁷ Department of Obstetrics and Gynecology, Reproductive Medicine Center, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.）

出处： Andrology 2024

关键词： TDRD5 variants;oligoasthenoteratozoospermia;pirna;spermiogenesis;whole exome sequencing.

摘要： Background: PiRNA pathway factors, including evolutionarily conserved Tudor domain-containing proteins, play crucial roles in suppressing transposons ...

作者： Chuanhe Jiang  ¹, Jingtao Huang  ¹, Jie Shao  ², Tingting Yang  ³, Ye Zhao  ⁴, Meijuan Huang  ⁵, Hongmei Yi  ⁶, Jimin Shi  ³, Liping Wan  ², Feng Chen  ⁴, Yang Cao  ⁵, Xiaoxia Hu  ¹ （Affiliations ¹ Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. ⁴ National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. ⁵ Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. ⁶ Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Cell transplantation 2024

关键词： EBV;T-PTLD;allo-HSCT;poor prognosis.

摘要： Posttransplant lymphoproliferative disorder (PTLD) is a rare lymphoid and/or plasmocytic proliferation that occurs after allogeneic hematopoietic stem ...

作者： Feng Gao ^{#  1}, Liren Jiang ^{#  1}, Tuanjie Guo ^{#  2}, Jun Lin ^{#  1}, Weiqing Xu ^{#  1}, Lin Yuan  ¹, Yaqin Han  ¹, Jiji Yang  ¹, Qi Pan  ², Enhui Chen  ³, Ning Zhang  ⁴, Siteng Chen  ⁵, Xiang Wang  ⁶ （Affiliations ¹ Pathology Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Pathology, Dongtai People's Hospital, Dongtai, Jiangsu, China. ⁴ Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zn12235@rjh.com.cn. ⁵ Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. siteng@sjtu.edu.cn. ⁶ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xiang.wang1@shgh.cn.）

出处： Journal of translational medicine 2024

关键词： Deep learning;Lymph node metastasis;Prognosis;Renal cell carcinoma;Whole slide images.

摘要： Background: Metastasis renal cell carcinoma (RCC) patients have extremely high mortality rate. A predictive model for RCC micrometastasis based on pat ...

作者： Yan Ma ^{#  1   2}, Ying Zhang ^{#  2}, Hui-Ying Zhang  ^{1   2}, Ya Zhao  ³, Xiu-Miao Li  ², Yi-Fei Jiang  ², Mu-Di Yao  ⁴, Qin Jiang  ^{5   6}, Biao Yan  ⁷ （Affiliations ¹ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. ² The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ⁴ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. mudiyao@163.com. ⁵ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. jiangqin710@126.com. ⁶ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. jiangqin710@126.com. ⁷ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. yanbiao@sjtu.edu.cn.）

出处： Journal of translational medicine 2024

关键词： Anti-angiogenic therapy;Exosomal formulation;Ocular vascular disease;Transfer RNA-derived fragment.

摘要： Background: Intravitreal injections of angiogenesis inhibitors have proved efficacious in the majority of patients with ocular angiogenesis. However, ...

作者： Yiyang Wang  ^{1   2}, Yunyan Ye  ³, Shengyi Shi  ³, Kehang Mao  ¹, Haonan Zheng  ¹, Xuguang Chen  ³, Hanting Yan  ³, Yiming Lu  ^{3   4   5}, Yong Zhou  ⁶, Weimin Ye  ^{7   8}, Jing Ye  ^{3   4   5}, Jing-Dong J Han  ^{1   9} （Affiliations ¹ Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing, China. ² Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China. ³ Emergency Department, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁴ Department of Geriatrics, International Laboratory in Hematology and Cancer, Medical Center on Aging of Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Ruijin Hospital/CNRS/Inserm/Cote d'Azur University, Shanghai, China. ⁵ The State Key Laboratory of Medical Genomics, Pole Sino-Francais de Recherche en Sciences Du Vivant et Genomique, Shanghai, China. ⁶ Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ School of Public Health, Fujian Medical University, Fuzhou, China. ⁸ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. ⁹ Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies, Chengdu, China.）

出处： Aging cell 2024

关键词： aging;diagnosis model;facial images;stroke.

摘要： Stroke is a major threat to life and health in modern society, especially in the aging population. Stroke may cause sudden death or severe sequela-lik ...

作者： Xiangxiao Li  ^{1   2}, Fengjiao Zhang  ¹, Libo Sun  ¹, Xiaojie Cai  ¹, Fangzhou Lou  ¹, Yang Sun  ¹, Min Gao  ¹, Zhikai Wang  ¹, Sibei Tang  ¹, Li Fan  ¹, Yue Wu  ¹, Xinping Jin  ¹, Siyu Deng  ¹, Zhenyao Xu  ¹, Xuxu Sun  ², Qun Li  ³, Honglin Wang  ¹ （Affiliations ¹ Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Biochemistry and Molecular Cell Biology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Journal of immunology (Baltimore, Md. : 1950) 2024

摘要： Psoriasis is a common inflammatory skin disorder with no cure. Mesenchymal stem cells (MSCs) have immunomodulatory properties for psoriasis, but the t ...

作者： Hangwei Chen  ¹, Fan Li  ², Yulong Ge  ¹, Junyi Liu  ¹, Xing Xing  ¹, Min Li  ², Zhilei Ge  ³, Xiaolei Zuo  ^{2   3}, Chunhai Fan  ^{2   3}, Shaopeng Wang  ², Fang Wang  ¹ （Affiliations ¹ Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200800, China. ² Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China. ³ School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhangjiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.）

出处： Advanced materials (Deerfield Beach, Fla.) 2024

关键词： Atrial fibrillation;Dox delivery;radiofrequency catheter ablation;tetrahedral DNA framework.

摘要： Pre-organizing molecular drug within a microenvironment is crucial for the development of efficient and controllable therapeutic systems. Here, we rep ...

作者： Jingwen Zhou ^{#  1}, Chunyan He ^{#  2}, Han Yang  ², Wen Shu  ², Qingzhong Liu  ³ （Affiliations ¹ Department of Clinical Laboratory, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Rd, Shanghai, 200071, People's Republic of China. ² Department of Clinical Laboratory, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. ³ Department of Clinical Laboratory, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 274 Zhijiang Middle Rd, Shanghai, 200071, People's Republic of China. jiaodamedicine@foxmail.com.）

出处： BMC microbiology 2024

关键词： Staphylococcus aureus;Genomics;Metabolomics;Small colony variant;Sulfamethoxazole-trimethoprim;Transcriptomics.

摘要： Background: Long-term treatment with trimethoprim-sulfamethoxazole (SXT) can lead to the formation of small-colony variants (SCVs) of Staphylococcus a ...

作者： Ling Xu  ¹, Yue Xuan Wang  ², Wei Wang  ³, Xue Fan  ⁴, Xue Yu Chen  ⁵, Tian Yun Zhou  ⁶, Yu He Liu  ⁷, Ye Yu  ⁸, Fan Yang  ⁹, Zhen Yu Ju  ⁹, Yong Zhou  ¹⁰, Deng Liang Wang  ¹¹ （Affiliations ¹ Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;NHC Key Lab of Reproduction Regulation, Shanghai Engineering Research Center of Reproductive Health Drugs and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China. ² Department of Applied Statistics, Johannes Kepler University Linz, Linz 4040, Austria. ³ Hematology Center, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics (Capital Medical University), Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China. ⁴ Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁵ Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China. ⁶ Clinical Medicine, School of Basic Medicine, Shanghai Medical College Fudan University, Shanghai 200032, China. ⁷ Department of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, China. ⁸ Administrative Office, Total Quality Management Office, Total Quality Management Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁹ The First Affiliated Hospital of Jinan University, Institute of Aging and Regenerative Medicine, Jinan University, Jinan 510632, Guangzhou, China. ¹⁰ Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;Department of Scientific Research, The First Affiliated Hospital of Huzhou University, Huzhou 313000, Zhejiang, China. ¹¹ Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China;Department of Neurosurgery, Binhai Branch of National Regional Medical Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350209, Fujian, China;Fujian Provincial Institutes of Brain Disorders and Brain Sciences, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China;Fujian Provincial Clinical Research Center for Neurological Diseases, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, Fujian, China.）

出处： Biomedical and environmental sciences : BES 2024

关键词： Female;Nabothian cyst;Nicotinamide adenine dinucleotide;Risk factor.

摘要： Objective: Little is known about the association between whole-blood nicotinamide adenine dinucleotide (NAD ⁺) levels and nabothian cysts. ...

作者： Zhenyu Yang  ¹, Xiu Shen  ¹, Junyi Jin  ¹, Xiaoyan Jiang  ^{1   2   3}, Wenqi Pan  ⁴, Chenyao Wu  ¹, Dehong Yu  ¹, Ping Li  ¹, Wei Feng  ^{1   2   5}, Yu Chen  ^{1   2   5} （Affiliations ¹ Materdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, P. R. China. ² School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, P. R. China. ³ School of Medicine, Shanghai University, Shanghai, 200444, P. R. China. ⁴ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P. R. China. ⁵ Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health) Wenzhou Institute of Shanghai University, Wenzhou, Zhejiang, 325088, P. R. China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024

关键词： cyanobacteria;sonoafterglow;sonodynamic therapy ferroptosis;sonosynthesis.

摘要： Photosynthesis, essential for life on earth, sustains diverse processes by providing nutrition in plants and microorganisms. Especially, photosynthesi ...