作者： Hui-Ying Zhang ^{#  1   2}, Qiu-Yang Zhang ^{#  1   2}, Qing Liu ^{#  1   2}, Si-Guo Feng  ^{1   2}, Yan Ma  ^{1   2}, Feng-Sheng Wang  ^{1   2}, Yue Zhu  ^{1   2}, Jin Yao  ^{3   4}, Biao Yan  ⁵ （Affiliations ¹ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. ² The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. ³ The Affiliated Eye Hospital, Nanjing Medical University, Nanjing, 210000, China. dryaojin@126.com. ⁴ The Fourth School of Clinical Medicine, Nanjing Medical University, Nanjing, 210000, China. dryaojin@126.com. ⁵ Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. biao.yan@shgh.cn.）

出处： Journal of nanobiotechnology 2025

关键词： ANGPT2;Exosomes;Ocular neovascularization;VEGFA;miR-205.

摘要： Pathological neovascularization is a hallmark of many vision-threatening diseases. However, some patients exhibit poor responses to current anti-VEGF ...

作者： Shuai Zhao ^{#  1}, Yan Wang ^{#  2}, Xiaoli Deng  ³, Xi Chen  ⁴, Zhaoyi Lu  ⁵ （Affiliations ¹ Department of Galactophore, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China. ² Medical Reproductive Center, Jiuquan Hospital, Shanghai General Hospital, Jiuquan, 735000, Gansu, China. ³ Changzhou Vocational Institute of Textile and Garment, Textile College, Changzhou, 213164, Jiangsu, China. ⁴ Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China. chenxi2882@jsph.org.cn. ⁵ Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China. luzhaoyi@jsph.org.cn.）

出处： Scientific reports 2025

关键词： Adverse drug reactions (ADRs);Adverse events (AEs);Cetuximab;Head and neck cancer;Preferred terms (PTs);System organ class (SOC).

摘要： This study aims to monitor and identify adverse events (AEs) associated with cetuximab, a drug used to treat various late-stage (metastatic) tumors, t ...

作者： Qianhua Fang^1,2,3;Linmin Ye^1,2,3;Luyu Han^4,3;Shuangshuang Yao^5,3;Qianyun Cheng^1,2;Xing Wei^1,2;Yan Zhang^1,2;Juelin Huang^1,2;Guang Ning^1,2;Jiqiu Wang^1,2CA1;Yifei Zhang^1,2CA2;Zhiguo Zhang^1,2CA3 （¹Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;³These authors contributed equally as first authors.;⁴Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China;⁵Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Free Radical Biology and Medicine 2025

摘要： Aims/hypothesis Emerging evidence underscored the significance of leucine-rich repeat-containing G protein-coupled receptor (LGR) 4 in endocrine and m ...

作者： Wanheng Zhang  ¹, Shuqin Liu  ², Yan Hou  ², Shihui Xu  ², Jiayan An  ³, Kyubae Lee  ⁴, Qi Miao  ⁵, Nana Wang  ⁶, Yongtao Wang  ⁷, Mengze Ma  ⁸ （Affiliations ¹ Medical 3D Printing Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China; Department of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. ² School of Medicine, Shanghai University, Shanghai 200444, China. ³ School of Life Science, University of Liverpool, Liverpool L69 3BX, UK. ⁴ Department of Biomedical Materials, Konyang University, Daejeon 35365, Republic of Korea. ⁵ Department of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. ⁶ Department of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. Electronic address: wang-nana@sjtu.edu.cn. ⁷ School of Medicine, Shanghai University, Shanghai 200444, China. Electronic address: yongtao_wang@shu.edu.cn. ⁸ Medical 3D Printing Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450000, China. Electronic address: mengzema@outlook.com.）

出处： Journal of controlled release : official journal of the Controlled Release Society 2025

关键词： Antitumor immunity;Cell force adjustment;Cytoskeleton remodeling;Immunosuppressive nanoplatform;Mechanotransduction.

摘要： Immune cells are sensitive to the perception of mechanical stimuli in the tumor microenvironment. Changes in biophysical cues within tumor tissue can ...

作者： Yikeng Huang ^{#  1   2   3   4   5}, Xinyu Zhang ^{#  1   2   3   4   5}, Li Liang ^{#  1   2   3   4   5}, Yujin Jiang  ^{1   2   3   4   5}, Bo Li  ^{1   2   3   4   5   6}, Xinyu Zhu  ^{1   2   3   4   5}, Chenxin Li  ^{1   2   3   4   5}, Chufeng Gu  ^{1   2   3   4   5}, Wenjun Zou  ⁷, Zhi Zheng  ^{1   2   3   4   5   8   9}, Shuzhi Zhao  ^{1   2   3   4   5} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² National Clinical Research Centre for Eye Diseases, Shanghai, China. ³ Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. ⁴ Shanghai Engineering Centre for Visual Science and Photomedicine, Shanghai, China. ⁵ Shanghai Engineering Centre for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ⁶ Department of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou, China. ⁷ Wuxi No. 2 People's Hospital, Jiangnan University Medical Centre, Wuxi, China. ⁸ Ningde Municipal Hospital of Ningde Normal University, Fujian Medical University, Ningde, China. ⁹ Fujian Medical University, Fuzhou, China.）

出处： Journal of global health 2025

摘要： Background: Recreational screen time (RST) has been found to be associated with cognitive decline and neurodegenerative diseases. However, the associa ...

作者： Ruhui Shen  ¹, Jian'an Wang  ², Yijin Zhao  ², Zhaojin Dang  ², Ke Zhang  ², Ming Li  ², Qian Yang  ², Li-Na Gao  ³ （Affiliations ¹ College of Pharmacy, Jining Medical University, Rizhao, Shandong 276800, PR China; College of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, PR China; Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai 20080, PR China. ² College of Pharmacy, Jining Medical University, Rizhao, Shandong 276800, PR China. ³ College of Pharmacy, Jining Medical University, Rizhao, Shandong 276800, PR China; College of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, PR China; Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, Shandong 272067, PR China; Jining Key Laboratory of Depression Prevention and Treatment, Jining Medical University, Jining, Shandong 272067, PR China. Electronic address: linagao228@126.com.）

出处： International journal of biological macromolecules 2025

关键词： AKT/GSK3β/β-catenin/CBP/BDNF pathway;Depression;Polysaccharides from Scrophularia ningpoensis Hemsl..

摘要： Scrophularia ningpoensis Hemsl. is a traditional Chinese medicine used to regulate blood sugar levels, immunity, etc. We previously isolated polysacch ...

作者： Dawei Wang  ¹, Feng Shi  ², Dingguo Zhang  ³, Hui Wang  ⁴, Yu Zhu  ¹, Jun Wang  ^{5   6   7} （Affiliations ¹ Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² CAAC East China Aviation Personnel Medical Appraisal Center, Civil Aviation Shanghai Hospital, Shanghai, China. ³ Department of Urology, Shanghai Pudong New Area People's Hospital, Shanghai, China. ⁴ Department of Urology, Shanghai Anting Hospital, Shanghai, China. ⁵ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Urology, Ningde Clinical Medical College of Fujian Medical University, Ningde, China. ⁷ Department of Urology, Ningde Municipal Hospital of Ningde Normal University, Ningde, China.）

出处： Renal failure 2025

关键词： Kidney stones;atherogenic index of plasma;dyslipidemia;nested case-control study.

摘要： Objective: To investigate the association between atherogenic index of plasma (AIP) and risk of incident kidney stones. Methods: A nested case-control ...

作者： Yifei Zhang^1,2;Ruixin Liu^1,2;Yufei Chen^1,2;Zhiwen Cao^1,2;Cong Liu^1,2;Riqiang Bao¹;Yufan Wang³;Shan Huang⁴;Shijia Pan⁵;Li Qin⁶;Jiqiu Wang¹;Guang Ning¹CA1;Weiqing Wang^1,7CA2 （¹Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;²These authors contributed equally;³Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;⁴Department of Endocrinology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China;⁵Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China;⁶Department of Endocrinology, Chongming hospital affiliated to Shanghai University of Health & Medicine Sciences, Shanghai 202150, China;⁷Lead contact）

出处： Cell Metabolism 2025

摘要： Akkermansia muciniphila is a promising target for managing obesity and type 2 diabetes (T2D), but human studies are limited. We conducted a 12-week ra ...

作者： Hui Ran ^{#  1}, Yemin Zhu ^{#  2}, Ruyuan Deng ^{#  1}, Qi Zhang  ¹, Xisheng Liu  ³, Ming Feng  ², Jie Zhong  ², Shuhai Lin  ², Xuemei Tong  ⁴, Qing Su  ⁵ （Affiliations ¹ Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665, Kong Jiang Road, Shanghai, 200092, China. ² Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China. ³ Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100, Haining Road, Shanghai, 200080, China. ⁴ Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, 280 S. Chongqing Road, Shanghai, 200025, China. xuemeitong@shsmu.edu.cn. ⁵ Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665, Kong Jiang Road, Shanghai, 200092, China. suqing@xinhuamed.com.cn.）

出处： Journal of experimental & clinical cancer research : CR 2025

作者： Jiawei Zhang  ^{1   2}, Feng Ding  ³, Yitian Guo  ^{1   2}, Xiaoying Wei  ^{2   4}, Jibo Jing  ⁵, Feng Xu  ⁶, Huixing Chen  ⁷, Zhongying Guo  ⁸, Zonghao You  ^{1   2}, Baotai Liang  ^{1   2}, Ming Chen  ^{1   2}, Dongfang Jiang  ⁹, Xiaobing Niu  ¹⁰, Xiangxue Wang  ¹¹, Yifeng Xue  ^{12   13} （Affiliations ¹ Department of Urology, Zhongda Hospital, Southeast University, Nanjing, China. ² Department of Medical College, Southeast University, Nanjing, China. ³ Nanjing University of Information Science and Technology, Nanjing, China. ⁴ Department of Pathology, Zhongda Hospital, Southeast University, Nanjing, China. ⁵ Department of Urology, Peking Union Medical College Hospital, Beijing, China. ⁶ Jinhu County People's Hospital, Huai'an, China. ⁷ Shanghai General Hospital, Urologic Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁸ Department of Pathology, Huaian First People's Hospital, Huai'an, China. ⁹ Department of Urology, The People's Hospital of Danyang, Danyang, China. 13912823872@163.com. ¹⁰ Department of Urology, Huaian First People's Hospital, Huai'an, China. nxbhayy@163.com. ¹¹ Nanjing University of Information Science and Technology, Nanjing, China. xwang@nuist.edu.cn. ¹² The Affiliated Jintan Hospital of Jiangsu University, Changzhou, China. 494809908@qq.com. ¹³ Changzhou jintan first people's hospital, Changzhou, China. 494809908@qq.com.）

出处： Scientific reports 2025

摘要： Biochemical recurrence (BCR) of prostate cancer (PCa) negatively impacts patients' post-surgery quality of life, and the traditional predictive models ...