作者： Sihan Du  ¹, Ximin Shen  ², Yi Sun  ², Jia Li  ², Juan Wang  ², Yiting Cai  ³, He Li  ⁴ （Affiliations ¹ Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China; Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. ² Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China. ³ Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China. Electronic address: caiyitingd@qq.com. ⁴ Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China. Electronic address: lihe@bjmu.edu.cn.）

出处： Clinics and research in hepatology and gastroenterology 2024

关键词： Alanine aminotransferase;HBV e antigen;Hepatitis B;PreS1;Viral hepatitis.

摘要： Background and aim: Hepatitis B virus (HBV) infection presents with indicators of varying clinical significance. We aimed to evaluate the correlation ...

作者： Siteng Chen  ¹, Feng Gao  ², Tuanjie Guo  ³, Liren Jiang  ², Ning Zhang  ⁴, Xiang Wang  ³, Junhua Zheng  ¹ （Affiliations ¹ Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine. ² Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. ³ Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. ⁴ Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.）

出处： International journal of surgery (London, England) 2024

摘要： Background: Although separate analysis of individual factor can somewhat improve the prognostic performance, integration of multimodal information int ...

作者： Enci Dai  ¹, Wei Wang  ², Yingying Li  ³, Defeng Ye  ⁴, Yanli Li  ⁵ （Affiliations ¹ Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Shanghai, 201600, China. Electronic address: daiencixixi@sjtu.edu.cn. ² Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Shanghai, 201600, China. Electronic address: wangwei980423@sjtu.edu.cn. ³ Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Shanghai, 201600, China. Electronic address: liyingying1119@sjtu.edu.cn. ⁴ Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Hongkou District, Shanghai, 200080, China. Electronic address: yardphone0326@sjtu.edu.cn. ⁵ Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Shanghai, 201600, China. Electronic address: liecho121@126.com.）

出处： Cancer letters 2024

摘要： There is growing evidence that lactate can have a wide range of biological impacts in addition to being a waste product of metabolism. Because of the ...

作者： Wan Sun  ¹, Juan Wang  ², Caiying Liu  ¹, Furong Gao  ¹, Qingjian Ou  ³, Haibin Tian  ¹, Jingying Xu  ¹, Jieping Zhang  ³, Jiao Li  ⁴, Jie Xu  ⁴, Song Jia  ⁴, Jingfa Zhang  ⁵, GuoTong Xu  ⁶, Jian Huang  ⁷, Caixia Jin  ⁸, Lixia Lu  ⁹ （Affiliations ¹ Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai 200065, China. ² Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Medical Genetics, School of Medicine, Tongji University, Shanghai 200065, China. ³ Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Pharmacology, School of Medicine, Tongji University, Shanghai 200065, China. ⁴ Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai 200065, China. ⁵ Department of Ophthalmology, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 200025, China. ⁶ Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Pharmacology, School of Medicine, Tongji University, Shanghai 200065, China. Electronic address: gtxu@tongji.edu.cn. ⁷ Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: jyhuanj@shsmu.edu.cn. ⁸ Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai 200065, China. Electronic address: 12060@tongji.edu.cn. ⁹ Department of Ophthalmology of Shanghai Tongji Hospital and Laboratory of Clinical Visual Science of Tongji Eye Institute, Tongji University, Shanghai 200065, China; Department of Biochemistry and Molecular Biology, School of Medicine, Tongji University, Shanghai 200065, China. Electronic address: lulixia@tongji.edu.cn.）

出处： International journal of biological macromolecules 2024

关键词： Glia maturation factor-β (GMFB);Hyperglycemia;Protein stability;Retinal pigment epithelial cells;SUMOylation.

摘要： Background: Glia maturation factor beta (GMFB) is a growth and differentiation factor that acts as an intracellular regulator of signal transduction p ...

作者： Shuchang Zhang  ¹, Shimei Chen  ¹, Dandan Sun  ¹, Shenping Li  ¹, Jun Sun  ¹, Qing Gu  ¹, Peiyu Liu  ¹, Xiaoqian Wang  ¹, Hong Zhu  ¹, Xun Xu  ¹, Huiming Li  ², Fang Wei  ³ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ² Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: li_huiming73@163.com. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: weifang73@hotmail.com.）

出处： Cellular signalling 2024

关键词： Diabetic retinopathy;Mitophagy;Senescence;TIN2;mTOR.

摘要： The telomere-associated protein TIN2 localizes to both telomeres and mitochondria. Nevertheless, the impact of TIN2 on retinal pigment epithelial (RPE ...

作者： Lingxuan Zhu MD^1,2;Weiming Mou MD^3,2;Peng Luo MD¹CA1 （¹Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China;²Lingxuan Zhu and Weiming Mou have contributed equally to this work and share first authorship.;³Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Clinical Gastroenterology and Hepatology 2024

作者： Youwei Lu  ¹, Yu Sun  ¹, Jie Zhang  ¹, Miao Kong  ¹, Zhiming Zhao  ¹, Boshu Sun  ¹, Yuan Wang  ¹, Ying Jiang  ², Shaomu Chen  ³, Chao Wang  ⁴, Yin Tong  ⁵, Liangzhu Wen  ⁶, Moli Huang  ⁷, Fengying Wu  ⁸, Liang Zhang  ⁹ （Affiliations ¹ College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China. ² Department of Hematology, Shanghai Zhaxin Traditional Chinese and Western Medicine Hospital, Shanghai, China. ³ Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. ⁴ Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, Jiangsu, China. ⁵ Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ He Cheng Biotechnology Suzhou Co.Ltd, Suzhou, Jiangsu, China. ⁷ Department of Bioinformatics, School of Biology & Basic Medical Sciences, Soochow University, Suzhou, China. ⁸ Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: 1701823@tongji.edu.cn. ⁹ College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China. Electronic address: zliang@suda.edu.cn.）

出处： Cancer letters 2024

关键词： B7–H4;Deubiquitination;EGFR MT;Tumor immunosuppression;USP2a.

摘要： B7-H4 is an immune checkpoint crucial for inhibiting CD8⁺ T-cell activity. A clinical trial is underway to investigate B7-H4 as a potential ...

作者： Jingwen Chen  ¹, Rui Yang  ², Hongwei Yu  ¹, Hao Wu  ³, Nan Wu  ³, Suhe Wang  ⁴, Xiaorui Yin  ¹, Xiangyang Shi  ², Han Wang  ^{1   5   6   7} （Affiliations ¹ Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Haining Rd.100, Shanghai 200080, China. han.wang@shsmu.edu.cn. ² Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China. ³ School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China. ⁴ Department of Internal Medicine, Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA. ⁵ R & D Center of Medical Artificial Intelligence and Medical Engineering, Haining Rd.100, Shanghai General Hospital, Shanghai 200080, China. ⁶ National Center for Translational Medicine (Shanghai), New Songjiang Rd.650, Shanghai 201620, China. ⁷ Jiading Branch of Shanghai General Hospital, Huangjia Garden Rd. 800, Shanghai 201803, China.）

出处： Journal of materials chemistry. B 2024

摘要： Ultrasmall iron oxide nanoparticles (USIO NPs) are expected to become the next generation T₁ contrast agents; however, their diagnostic and ...

作者： Yuan Liu  ¹, Jinxin Zheng  ², Qining He  ¹, Haijiao Zhang  ³, Peizhen Wen  ⁴, Peihao Wen  ⁵, Jifu Ge  ⁶, Yang Yang  ⁷, Tao Zhang  ⁸, Rangrang Wang  ³ （Affiliations ¹ Department of Liver Transplantation, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai, China. ³ Huadong Hospital Affiliated to Fudan University, Shanghai, China. ⁴ Organ Transplantation Institute of Xiamen University, Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Xiamen University, Xiamen, China. ⁵ Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. ⁶ Department of Kidney Transplantation, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ⁷ School of Public Health, Imperial College London, South Kensington Campus, London SW72AZ, United Kingdom. ⁸ Department of Kidney Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.）

出处： International journal of surgery (London, England) 2024

摘要： The success of solid organ transplantation (SOT) and the use of immunosuppressive agents offer hope to patients with end-stage diseases. However, the ...

作者： Rui Kong  ¹, Nan Wang  ², Chun Li Zhou  ¹, Jie Lu  ^{3   2} （Affiliations ¹ Department of Gastroenterology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Gusu School, Nanjing Medical University, P.R. China. ² Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China. ³ Department of Gastroenterology, Pu Dong Area Gongli Hospital, School of Medicine, Shanghai University, Shanghai 200135, P.R. China.）

出处： Journal of microbiology and biotechnology 2024

关键词： Long non-coding RNA;hepatocellular carcinoma;immune prognostic signature;overall survival.

摘要： In recent years, there has been a growing recognition of the important role that long non-coding RNAs (lncRNAs) play in the immunological process of h ...