作者： Zhi-Hao Du  ¹, Wei-Xia Chu  ^{2   3}, Xin Peng  ¹, Li-Ling Wu  ⁴, Yan Liu  ², Guang-Yan Yu  ¹, Chong Ding  ² （Affiliations ¹ Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No. 22, Zhongguancun South Avenue, Haidian District, Beijing 100081, P. R. China. ² Center Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No. 22, Zhongguancun South Avenue, Haidian District, Beijing 100081, P. R. China. ³ Shanghai General Hospital, Shanghai 200080, P. R. China. ⁴ Department of Physiology and Pathophysiology, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Peking University School of Basic Medical Sciences, Beijing 100191, P. R. China.）

出处： ACS applied materials & interfaces 2025

关键词： Sjögren’s syndrome;T-bet;Th1 cell;exosomes;miR-29a-3p;saliva.

摘要： Background: Sjögren's syndrome (SS), an autoimmune disease, was characterized by sicca syndrome and systemic manifestations, presenting significant tr ...

作者： Guiping Kong  ¹, Yayue Song  ¹, Yuyang Yan  ¹, Samantha M Calderazzo  ², Madhu Sudhana Saddala  ³, Fabian De Labastida Rivera  ⁴, Jonathan D Cherry  ², Noah Eckman  ⁵, Eric A Appel  ⁵, Adam Velenosi  ⁶, Vivek Swarup  ³, Riki Kawaguchi  ⁷, Susanna S Ng  ⁸, Brian K Kwon  ⁹, David Gate  ¹⁰, Christian R Engwerda  ⁴, Luming Zhou  ¹¹, Simone Di Giovanni  ¹² （Affiliations ¹ Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK. ² Department of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Boston University Alzheimer's Disease and CTE Centers, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. ³ Department of Neurobiology and Behaviour, School of Biological Sciences, University of California Irvine, Irvine, CA, USA. ⁴ QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. ⁵ Department of Chemical Engineering, Stanford University, Stanford, CA, USA; Department of Materials Science & Engineering, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Paediatrics, Endocrinology, Stanford University, Stanford, CA, USA; ChEM-H Institute, Stanford University, Stanford, CA, USA; Woods Institute for the Environment, Stanford University, Stanford, CA, USA. ⁶ International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Praxis Spinal Cord Institute, Vancouver, BC, Canada. ⁷ Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Semel Institute for Neuroscience and Human Behaviour, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ⁸ QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; Institute of Experimental Oncology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany. ⁹ International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada. ¹⁰ The Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ¹¹ Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK; Precision Research Center for Refractory Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. Electronic address: l.zhou13@imperial.ac.uk. ¹² Molecular Neuroregeneration, Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK. Electronic address: s.di-giovanni@imperial.ac.uk.）

出处： Neuron 2025

关键词： CD8(+) T cells;NKG7;NKLT cells;aging;granzyme K;regeneration;repair;spinal cord injury;wound healing.

摘要： Spinal cord injury (SCI) increasingly affects aged individuals, where functional impairment and mortality are highest. However, the aging-dependent me ...

作者： Yichao Ma^1,2;Peng Lai^1,2;Zhou Sha^3,2;Bing Li⁴;Jiangpeng Wu¹;Xiaojun Zhou⁴CA1;Chuanglong He⁴CA2;Xiaojun Ma¹CA3 （¹Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China;²Yichao Ma, Peng Lai and Zhou Sha contributed equally to this work.;³Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 200092, China;⁴College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China）

出处： Bioactive Materials 2025

关键词： MYC-amplified osteosarcoma;Nanocomposite hydrogel;Tumor microenvironment;Targeted delivery;Combination therapy

摘要： The oncogene MYC is one of the most commonly activated oncogenic proteins in human tumors, with nearly one-fourth of osteosarcoma showing MYC amplific ...

作者： Qianhua Fang^1,2,3;Linmin Ye^1,2,3;Luyu Han^4,3;Shuangshuang Yao^5,3;Qianyun Cheng^1,2;Xing Wei^1,2;Yan Zhang^1,2;Juelin Huang^1,2;Guang Ning^1,2;Jiqiu Wang^1,2CA1;Yifei Zhang^1,2CA2;Zhiguo Zhang^1,2CA3 （¹Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;³These authors contributed equally as first authors.;⁴Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China;⁵Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Free Radical Biology and Medicine 2025

摘要： Aims/hypothesis Emerging evidence underscored the significance of leucine-rich repeat-containing G protein-coupled receptor (LGR) 4 in endocrine and m ...

作者： Anqi Lin¹;Aimin Jiang²;Lihaoyun Huang¹;Yu Li¹;Chunyanx Zhang¹;Lingxuan Zhu¹;Weiming Mou³;Zaoqu Liu⁴;Jian Zhang¹;Quan Cheng⁵CA;Ting Wei¹CA;Peng Luo⁶ （¹a Department of Oncology, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue, Guangzhou, Guangdong, China;²b Department of Urology, Changhai hospital, Naval Medical University (Second Military Medical University), Shanghai, China;³a Department of Oncology, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue, Guangzhou, Guangdong, China;c Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴d Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China;⁵e Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China;f National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Hunan, China;⁶a Department of Oncology, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue, Guangzhou, Guangdong, China;g Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, 999078, China）

出处： Gut Microbes 2025

关键词： Fecal Microbiota Transplantation;immune checkpoint inhibitors;controversial effects;cancer immunotherapy;microbiome modulation

摘要： The integration of fecal microbiota transplantation (FMT) with immune checkpoint inhibitors (ICIs) presents a promising approach for enhancing cancer ...

作者： Yan Shen  ¹, Xin Li  ², Huiyan Zhang  ², Jian Chang  ^{3   4}, Xingmei Zhou  ³ （Affiliations ¹ Department of Intensive Care Unit, Shanghai General Hospital, Shanghai, China. ² Department of Vascular Access Outpatient, Shanghai General Hospital, Shanghai, China. ³ Department of Nursing, Shanghai General Hospital, Shanghai, China. ⁴ Shanghai Jiao Tong University School of Nursing, Shanghai, China.）

出处： Nursing in critical care 2025

关键词： catheterization;central venous catheters;device implantation;echocardiography;ports.

摘要： This is a prospective observational study designed to develop an echocardiography-guided tip location program for central venous catheter (CVC) implan ...

作者： Xiaoqin Wang ^{#  1}, Chuanfeng Pei ^{#  1}, Chao Jia  ¹, Long Liu  ², Hongmei Liang  ³ （Affiliations ¹ Department of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. ² Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. 13817309541@163.com. ³ Department of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. Tongtong_0929@126.com.）

出处： BMC nursing 2025

关键词： Fine needle aspiration cytology;Kano model;Nursing service needs.

摘要： Background: Thyroid nodules are common, and fine needle aspiration biopsy (FNAB) is essential for diagnosis and treatment. Patients' service needs are ...

作者： Pengfei Zan ^{#  1}, Yi Zhang ^{#  2}, Yidong Zhu ^{#  3}, Qingjing Chen  ⁴, Zhengwei Duan  ², Yonghao Guan  ², Kaiyuan Liu  ⁵, Anquan Shang  ⁶, Zihua Li  ⁷ （Affiliations ¹ Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. ² Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. ³ Department of Traditional Chinese Medicine, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. ⁴ Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510630, China. ⁵ Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. liuky2019@163.com. ⁶ Department of Laboratory Medicine, The Second People's Hospital of Lianyungang, Bengbu Medical College, Lianyungang, 222006, China. shanganquan@tongji.edu.cn. ⁷ Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China. lizihua@tongji.edu.cn.）

出处： Discover oncology 2025

关键词： Aging;Cellular senescence;Sarcoma;Tumor microenvironment.

摘要： Sarcoma (SARC), a diverse group of stromal tumors arising from mesenchymal tissues, is often associated with a poor prognosis. Emerging evidence indic ...

作者： Lijuan He ^{#  1   2}, Jize Wang ^{#  1   2}, Weigao Pu  ^{1   2}, Haiyuan Li  ^{1   2}, Ben Liu  ^{1   2}, Zhuanfang Wang  ^{1   2}, Qinying Han  ^{1   2}, Yunpeng Wang  ^{1   2}, Bo Xu  ^{1   2}, Jike Hu  ^{1   2}, Guodong Sun  ^{1   2}, Hao Chen  ^{3   4   5   6   7   8} （Affiliations ¹ The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China. ² Department of Surgical Oncology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China. ³ The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China. ery_chenh@lzu.edu.cn. ⁴ Department of Surgical Oncology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China. ery_chenh@lzu.edu.cn. ⁵ Gansu Provincial Key Laboratory of Environmental Oncology, Lanzhou, 730030, China. ery_chenh@lzu.edu.cn. ⁶ Humanized animal model laboratory, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730030, China. ery_chenh@lzu.edu.cn. ⁷ Shanghai Jiao Tong University School of Medicine, Shanghai, China. ery_chenh@lzu.edu.cn. ⁸ Shanghai General Hospital, Shanghai, China. ery_chenh@lzu.edu.cn.）

出处： BMC cancer 2025

关键词： Chemotherapy-induced nausea and vomiting;Fosaprepitant;Pan-cancer;Real world.

摘要： Background: Chemotherapy-induced nausea and/or vomiting (CINV) is an intractable adverse effect of anticancer drugs. Although prophylactic use of fosa ...

作者： Yichao Ma  ^{1   2}, Jiangpeng Wu  ², Yanlong Dong  ³, Hongmei Tang  ¹, Xiaojun Ma  ² （Affiliations ¹ Shanghai University of Traditional Chinese Medicine, Shanghai, China. ² Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Linyan Medical Technology Company Limited, Shanghai, China.）

出处： Orthopaedic surgery 2025

关键词： accuracy;augmented reality;navigation;pedicle screw;thoracolumbar spine.

摘要： Objective: The pedicle screw insertion technique has evolved significantly, and despite the challenges of precise placement, advancements like AR-base ...