作者： X B Cai  ¹, Y Qu  ¹, L G Lu  ¹ （Affiliation ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.）

出处： Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2024

关键词： Liver fibrosis;New drugs;Research and development.

摘要： Liver fibrosis is a key step in the developmental process of various chronic liver diseases, including cirrhosis. Therefore, the focus and difficulty ...

作者： Xinwan Wu ^{#  1}, Yuwei Chen ^{#  2}, Meiru Jiang ^{#  1}, Long Guo  ¹ （Affiliations ¹ Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Wannan Medical College, Wuhu, China.）

出处： Translational gastroenterology and hepatology 2024

关键词： Concanavalin A-induced acute hepatitis (ConA-induced acute hepatitis);SMI-4a;cleaved caspase-3 (c-caspase-3);phosphorylated p65 (p-p65);serine/threonine kinase 1 (PIM1).

摘要： Background: Serine/threonine kinase 1 (PIM1) plays a crucial role in cell growth, differentiation, and apoptosis. However, its role in the pathogenesi ...

作者： X Luo  ¹, L G Lu  ¹, Y M Mao  ² （Affiliations ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ² Department of Gastroenterology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China.）

出处： Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 2024

关键词： Clinical trials;Drug targets;Fatty liver;Metabolic dysfunction associated fatty liver disease (MASLD);Research progress.

摘要： Metabolic dysfunction-associated fatty liver disease (MASLD) is a major public health problem that seriously affects human health. At present, some go ...

作者： Jiaqiang Ma ^{#  1}, Yingcheng Wu ^{#  1}, Lifeng Ma ^{#  2}, Xupeng Yang ^{#  1}, Tiancheng Zhang ^{#  1}, Guohe Song  ¹, Teng Li  ³, Ke Gao  ¹, Xia Shen  ¹, Jian Lin  ¹, Yamin Chen  ³, Xiaoshan Liu  ³, Yuting Fu  ², Xixi Gu  ³, Zechuan Chen  ³, Shan Jiang  ³, Dongning Rao  ¹, Jiaomeng Pan  ¹, Shu Zhang  ¹, Jian Zhou  ¹, Chen Huang  ⁴, Si Shi  ⁵, Jia Fan  ¹, Guoji Guo  ², Xiaoming Zhang  ³, Qiang Gao  ¹ （Affiliations ¹ Department of Liver Surgery and Transplantation, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China. ² Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, and Stem Cell Institute, Zhejiang University, Hangzhou 310058, China. ³ The Center for Microbes, Development and Health, Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China. ⁴ Department of Gastrointestinal Surgery, Shanghai General Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200080, China. ⁵ Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.）

出处： Science (New York, N.Y.) 2024

摘要： B lymphocytes are essential mediators of humoral immunity and play multiple roles in human cancer. To decode the functions of tumor-infiltrating B cel ...

作者： Angela C C Jochems  ^{1   2}, Susana Muñoz Maniega  ^{1   2}, Francesca M Chappell  ^{1   2}, Una Clancy  ^{1   2}, Carmen Arteaga  ^{1   2}, Daniela Jaime Garcia  ^{1   2}, Olivia K L Hamilton  ^{1   2   3}, Will Hewins  ^{1   2}, Rachel Locherty  ^{1   2}, Ellen V Backhouse  ^{1   2}, Gayle Barclay  ^{1   4}, Charlotte Jardine  ^{1   4}, Donna McIntyre  ^{1   4}, Iona Gerrish  ^{1   4}, Yajun Cheng  ^{1   2   5}, Xiaodi Liu  ^{1   2   6}, Junfang Zhang  ^{1   2   7}, Agniete Kampaite  ¹, Eleni Sakka  ¹, Maria Valdés Hernández  ^{1   2}, Stewart Wiseman  ^{1   2}, Michael S Stringer  ^{1   2}, Michael J Thrippleton  ^{1   2   4}, Fergus N Doubal  ^{1   2}, Joanna M Wardlaw  ^{1   2   4} （Affiliations ¹ Centre for Clinical Brain Sciences, University of Edinburgh, EH16 4SB Edinburgh, United Kingdom. ² MRC UK Dementia Research Institute at the University of Edinburgh, EH16 4SB Edinburgh, United Kingdom. ³ MRC/CSO Social and Public Health Sciences Unit, School of Health and Wellbeing, University of Glasgow, G12 8TB Glasgow, United Kingdom. ⁴ Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, EH16 4TJ Edinburgh, United Kingdom. ⁵ Department of Neurology, West China Hospital of Sichuan University, 610041 Chengdu, China. ⁶ Department of Medicine, LKS Faculty of Medicine, University of Hong Kong, Hong Kong, China. ⁷ Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University School of medicine, 200080 Shanghai, China.）

出处： Brain communications 2024

关键词： dexterity;imaging;mobility;small vessel disease;white matter hyperintensity.

摘要： White matter hyperintensities (WMH), a common feature of cerebral small vessel disease, are related to worse clinical outcomes after stroke. We assess ...

作者： Qiaoyun Gong  ^{1   2   3   4   5}, Mingshui Fu  ^{1   2   3   4   5}, Jingyi Wang  ^{1   2   3   4   5}, Shuzhi Zhao  ^{1   2   3   4   5}, Haiyan Wang  ^{1   2   3   4   5} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China. ² National Clinical Research Center for Eye Diseases, Shanghai 200080, China. ³ Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai 200080, China. ⁴ Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, China. ⁵ Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease, Shanghai 200080, China.）

出处： Journal of proteome research 2024

关键词： COVID-19;cytokine;inflammation;macrophage;primary angle-closure glaucoma.

摘要： Primary acute angle-closure glaucoma (PAACG) is a sight-threatening condition that can lead to blindness. With the increasing incidence of COVID-19, a ...

作者： Hao Liu¹;Xuyuan Sun¹;Zhengyuan Dai¹;Ying Wang¹;Li Li¹;Jie Fan² & …Yaping Ding ¹ （¹Department of Chemistry, College of Sciences, Shanghai University, Shanghai, 200444, People’s Republic of China;²Department of Urology, School of Medicine, Shanghai First People’s Hospital, Shanghai Jiaotong University, Shanghai, 200080, People’s Republic of China）

出处： Microchimica Acta 2024

关键词： Molecularly imprinted polymer;Fluorescent sensor;Dual-emission;Carbon quantum dots;Nifedipine

摘要： Nifedipine (NIF), as one of the dihydropyridine calcium channel blockers, is widely used in the treatment of hypertension. However, misuse or ingestio ...

作者： Junhao Gu  ¹, Danling Cheng  ¹, Haiyan Li  ², Tao Yu  ¹, Zhenghe Zhang  ¹, Yue Liu  ¹, Xiaoying Wang  ³, Xia Lu  ², Jingchao Li  ¹ （Affiliations ¹ State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, P. R. China. jcli@dhu.edu.cn. ² Department of Nuclear Medicine, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou 225001, P. R. China. lxgf2222@163.com. ³ Office of Hospital Infection and Disease Control and Prevention, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P. R. China. goodwxyz@163.com.）

出处： Journal of materials chemistry. B 2024

摘要： Due to the rapid progression and aggressive metastasis of breast cancer, its diagnosis and treatment remain a great challenge. The simultaneous inhibi ...

作者： Ke Wu ^{1,2 na1};Yaorong Li^{1,2 na1};Kangli Ma^{1,2 na1};Weiguang Zhao³;Zhixian Yao ^1,2;Zhong Zheng ^1,2;Feng Sun³;Xingyu Mu³;Zhihong Liu³ & …Junhua Zheng ^1,2 （¹Institute of Molecular Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;³Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Cellular Oncology 2024

关键词： Microbiota;Renal cell carcinoma;Carcinogenesis;Microbiomics

摘要： Renal cell carcinoma (RCC) accounts for about 2% of cancer diagnoses and deaths worldwide. Recent studies emphasized the critical involvement of micro ...

作者： Jingwen Chen,‡^a and Rui Yang,‡^e and Hongwei Yu,^a and Hao Wu,^f and Nan Wu,^f and Suhe Wang,^g and Xiaorui Yin,^a and Xiangyang Shi ^e  and and Han Wang *^abcd   （* Corresponding authors ^a Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Haining Rd.100, Shanghai 200080, China E-mail: han.wang@shsmu.edu.cn ^b R & D Center of Medical Artificial Intelligence and Medical Engineering, Haining Rd.100, Shanghai General Hospital, Shanghai 200080, China ^c National Center for Translational Medicine (Shanghai), New Songjiang Rd.650, Shanghai 201620, China ^d Jiading Branch of Shanghai General Hospital, Huangjia Garden Rd. 800, Shanghai 201803, China ^e Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China ^f School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China ^g Department of Internal Medicine, Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA）

出处： Journal of Materials Chemistry B 2024

摘要： Ultrasmall iron oxide nanoparticles (USIO NPs) are expected to become the next generation T₁ contrast agents; however, their diagnostic and ...