作者： Zhenzhen Wei;Ziyuan Wang;Qiong Chai;Zan Li;Mengjie Zhang;Yuli Zhang;Lu Zhang;Qingfeng Tang;Huirong Zhu;Hua Sui （Affiliations ¹ Medical Experiment Center, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201803, P.R. China. ² Department of Medical Oncology, Shuguang Hospital, Shanghai 201203, P.R. China. ³ Department of Pathology, Shuguang Hospital, Shanghai 201203, P.R. China. ⁴ Office of Academic Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China. ⁵ Department of Integrated Chinese and Western Medicine, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China.）

出处： Experimental and therapeutic medicine 2023

关键词： cancer stem cell;cetuximab;colorectal cancer;exosome;resistance.

摘要： The anti-EGFR antibody cetuximab is used as a first-line targeted therapeutic drug in colorectal cancer. It has previously been reported that the effi ...

作者： Wen, Yu Jun;Yang, Wen Jia;Guo, Chun Ni;Qiu, Mei Hong;Kroeger, Daniel;Niu, Jian Guo;Zhan, Shu Qin;Yang, Xi Fei;Gisabella, Barbara;Vetrivelan, Ramalingam;Lu, Jun （¹Ningxia Key Laboratory of Craniocerebral Diseases, Department of Anatomy, Histology and Embryology, School of Basic Medicine, Ningxia Medical University ²Stroke Center, Department of Neurology, 1st Hospital of Jilin University ³Shanghai Yueyang Integrated Medicine Hospital ⁴Department of Neurology, Shanghai First People's Hospital, Shanghai Jiaotong University ⁵Department of Neurobiology, School of Basic Medical Science, Shanghai Medical College, Fudan University ⁶Department of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University ⁷Department of Neurology, Xuanwu Hospital, Capital Medical University ⁸Shenzhen Center for Disease Control and Prevention ⁹Department of Psychiatry and Human Behavior, University of Mississippi Medical Center ¹⁰Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School）

出处： CNS Neuroscience & Therapeutics 2023

关键词： fear memory;glutamate;hippocampus;medial septum;neural circuit;REM sleep;SLD

摘要： Aims Methods Results Conclusion We often experience dreams of strong irrational and negative emotional contents with postural muscle paralysis during ...

作者： Weiming Dai;Yuecheng Guo;Zhenyang Shen;Junjun Wang;Lungen Lu;Hui Dong;Xiaobo Cai （Affiliations ¹ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hui.dong@shgh.cn. ⁴ Shanghai Key Laboratory of Pancreatic Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China. hui.dong@shgh.cn. ⁵ Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. xiaobo.cai@shgh.cn.）

出处： Human cell 2023

关键词： Differentially expressed gene;Hepatic stellate cell;Liver fibrosis;Protein–protein interaction.

摘要： Liver fibrosis is a pathological response driven by the activation of hepatic stellate cell (HSC). However, the mechanisms of liver fibrosis and HSC a ...

作者： Fei Shi;Lei Wu;Di Cui;Menghao Sun;Yuanhao Shen;Zheng Zhou;Zheng Deng;Bangmin Han;Shujie Xia;Zheng Zhu;Feng Sun （Affiliations ¹ Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China. ² Department of Urology, Shanghai General Hospital, Nanjing Medical University, Shanghai, 200080, China. ³ Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. ⁴ School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. ⁵ Department of Internal Medicine, Division of Hematology/Oncology, University of California Davis, Sacramento, CA, 95817, USA. zegzhu@ucdavis.edu. ⁶ Department of Urology, School of Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, 100 Haining Road, Shanghai, 200080, China. feng.sun@shgh.cn. ⁷ Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. feng.sun@shgh.cn.）

出处： Cellular oncology (Dordrecht) 2023

关键词： Castration-resistant prostate cancer (CRPC);PARP1;Self PARylation;lncFALEC.

摘要： Accumulating evidence indicates that long noncoding RNAs (lncRNAs) are abnormal expression in various malignant tumors. Our previous research demonstr ...

作者： Pusheng Yang;Jiawei Lu;Panpan Zhang;Shu Zhang （Affiliations ¹ Shanghai Key Laboratory of Gynecology Oncology, Department of Gynecology and Obstetrics, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. ² Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. ³ Shanghai Key Laboratory of Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China.）

出处： Diagnostics (Basel, Switzerland) 2023

关键词： ferroptosis;immunotherapy;lipid metabolism;prognostic marker;uterine corpus endometrial carcinoma.

摘要： (1) Background: The effect of tumor immunotherapy is influenced by the immune microenvironment, and it is unclear how lipid metabolism and ferroptosis ...

作者： Hongkun Li;Junxia Guo;Sudan Xu;Juan Xu;Lidong Cai;Bei Liu （Affiliations ¹ Department of Cardiology, Changzhi Medical College Affiliated Heji Hospital, Shangxi. ² Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical College, Henan. ³ Department of Cardiology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.）

出处： Acta Cardiologica Sinica 2023

关键词： CD45RO+CD8+;CD8+ T cells;Coronary slow flow.

摘要： Background: Circulating memory CD8+ T cells have been shown to be a crucial mediator of chronic inflammation. This study investigated whether the base ...

作者： Locatello, Luca Giovanni;Jiang, Serena;Chen, Lixiao;Caini, Saverio;Maggiore, Giandomenico;Dong, Pin;Gallo, Oreste （¹Department of Otorhinolaryngology, Careggi University Hospital ²Department of Otorhinolaryngology, University Hospital “Santa Maria Della Misericordia”, Azienda Sanitaria Universitaria Friuli Centrale (ASUFC) ³Department of Otolaryngology-Head & Neck Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University ⁴Department of Experimental and Clinical Medicine, University of Florence）

出处： European Archives of Oto-Rhino-Laryngology 2023

关键词： Adjuvant radiotherapy;Functional outcomes;Laryngeal cancer;Laryngeal surgery;OPLS;Partial laryngectomy;PORT

摘要： Background: The oncological and functional role of postoperative radiotherapy (PORT) after open partial laryngeal surgery (OPLS) remains debatable.A s ...

作者： Qiangsheng Hu;Jie Dai;Zheng Zhang;Huansha Yu;Jing Zhang;Xinsheng Zhu;Yi Qin;Lele Zhang;Peng Zhang （Affiliations ¹ Shanghai Pulmonary Hospital,Tongji University School of Medicine, shanghai, China, China. ² Zhongshan Hospital, Fudan, China. ³ Shanghai General hospital, Sjanghai Jiaotong university school of medicine, China. ⁴ Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, China. ⁵ Fudan University Shanghai Cancer Center, Shanghai, China. ⁶ Shanghai Pulmonary Hospital, Tongji University School of Medicine, shanghai, China.）

出处： Cancer research 2023

摘要： Induction of ferroptosis, a recently defined form of nonapoptotic cell death caused by iron-dependent lipid peroxidation, has emerged as an anti-cance ...

作者： Li, Jing;Yang, Yang;Wang, Wenjing;Xu, Jiadai;Sun, Yifeng;Jiang, Jifeng;Tan, Hui;Ren, Liang;Wang, Yue;Ren, Yuhong;Zhang, Yian;Xu, Tianhong;Jia, Xuebing;Huang, Xiaoyun;Liu, Peng （¹Department of Hematology, Zhongshan Hospital, Fudan University ²Cancer Centre, Zhongshan Hospital, Fudan University ³Department of Nuclear Medicine, Zhongshan Hospital, Fudan University ⁴Institute of Nuclear Medicine, Fudan University, Shanghai Institute of Medical Imaging ⁵Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine ⁶Centre for Systems Biology, Intelliphecy）

出处： British Journal of Haematology 2023

关键词： immunotherapy;macrophage;multiple myeloma;single‐cell;tumour microenvironment

摘要： The tumour microenvironment (TME) plays a critical role in disease progression in multiple myeloma (MM). This study aimed to present an atlas of MM‐TM ...

作者： Na Li;Xiang Xu;Dan Liu;Jiaxin Gao;Ying Gao;Xufeng Wu;Huiming Sheng;Qun Li;Jun Mi （Affiliations ¹ Hongqiao International Institute of Medicine, Tongren Hospital; Basic Medical Institute; Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine. ² Department of Laboratory Medicine, Shanghai General Hospital Jiading Branch, Shanghai. ³ College of Basic Medical Sciences, Dalian Medical University. ⁴ Department of Clinic Laboratory, Tongren Hospital, Shanghai Jiao Tong University School of Medicine. ⁵ Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine.）

出处： Theranostics 2023

关键词： GABA;GABA receptor;GPT2;breast cancer;calcium;metastasis.

摘要： Objectives: Glutamic pyruvate transaminase (GPT2) catalyzes the reversible transamination between alanine and α-ketoglutarate (α-KG) to generate pyruv ...