作者： Mi Shen^{1,2,3,4,5,6,7};Xinli Ye^{1,2,3,4,5,6,7};Qiang Zhou^{1,2,3,4,5,6,7};Mengru Zheng^{1,2,3,4,5,6,7};Mingzhi Du^{1,2,3,4,5,6,7};Lijuan Wang^1,3,4,5,6,7;Meng Cong^1,3,4,5,6,7;Chang Liu^1,3,4,5,6,7;Chunyan Deng^1,3,4,5,6,7;Zhen Xu^8,3,4,5,6,7;Yu Wang^8,3,4,5,6,7;Jiyu Li^9,3,4,5,6,7;Min Feng^9,3,4,5,6,7;Yujiao Ye^10,3,4,5,6,7;Shuyu Zhang^10,3,4,5,6,7;Wenqing Xu^10,3,4,5,6,7;Yi Lu^10,3,4,5,6,7;Junjie Kong^1,3,4,5,6,7;Jiahuan Gong^1,3,4,5,6,7;Yingjie Xia^10,3,4,5,6,7 （¹Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Nantong University, Nantong, Jiangsu, China;²These authors contributed equally to this work.;³Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴The Affiliated Nantong Stomatological Hospital of Nantong University, Nantong, China;⁵Nantong Institute of Genetics and Reproductive Medicine, Affiliated Maternity & Child Healthcare Hospital of Nantong University, Nantong, China;⁶Clinical Medical Research Center, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China;⁷School of Pharmacy, Nantong University, Nantong, Jiangsu Province, China;⁸Department of Clinical Medical Research Center, The Affiliated Suqian First People's Hospital of Nanjing Medical University, Jiangsu Province, China;⁹Department of Orthopedic Oncology, Second Affiliated Hospital of Naval Medical University, Shanghai, China;¹⁰Medical School of Nantong University, Nantong, Jiangsu, China）

出处： Journal of Biological Chemistry 2025

关键词： skin precursor-derived Schwann cells;extracellular vesicles;peripheral nerve injury;angiogenesis;miR-30a-5p;ANGPT2;LIF

摘要： Ischemia and hypoxia caused by vascular injury intensify nerve damage. Skin precursor-derived Schwann cells have demonstrated an accelerated in vivo p ...

作者： Yikeng Huang  ¹, Xiaoyin Xu  ¹, Xinyu Zhang  ¹, Xinyu Zhu  ¹, Bo Li  ^{1   2}, Mingming Ma  ¹, Chuandi Zhou  ³, Chufeng Gu  ¹, Yujin Jiang  ¹, Yanlin Wu  ⁴, Zhi Zheng  ^{1   5   6}, Shuzhi Zhao  ¹ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Eye Diseases; Shanghai Clinical Research Center for Eye Diseases; Shanghai Key Clinical Specialty; Shanghai Key Laboratory of Ocular Fundus Diseases; Shanghai Engineering Center for Visual Science and Photomedicine; Shanghai engineering center for precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ² Department of Ophthalmology, The Fourth Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, China. ³ Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. ⁴ Department of Ophthalmology, Fuyang Fifth People's Hospital, Fuyang City, Anhui Province, China. ⁵ Ningde Municipal Hospital of Ningde Normal University, Fujian Medical University, Ningde City, Fujian Province, China. ⁶ Fujian Medical University, Fuzhou City, Fujian Province, China.）

出处： Diabetes & vascular disease research 2025

关键词： Mendelian randomization;Sleep traits;UK Biobank;daytime sleepiness;diabetic retinopathy;observational study.

摘要： Aims: To evaluate the potential causal role of sleep traits (STs) on diabetic retinopathy (DR). Methods: The cross-sectional study included 23,851 pat ...

作者： Jingwen Jiang MD^1,2;Kangjie Kong MD^1,2;Fengbin Lin MD, PhD¹CA1;Fengqi Zhou OD³;Yunhe Song MD, PhD¹;Xiaoyi Liu MD¹;Zige Fang MD¹;Dilimulati Xiaokaiti MD^1,4;Ling Jin MSc¹;Meiling Chen MBBS¹;Jost B. Jonas MD, PhD^5,6;Dennis S.C. Lam MD^7,8;Linda M. Zangwill PhD⁹;Xiaodong Sun MD, PhD^10,11,12CA2;Robert N. Weinreb MD⁹CA3;Fei Li MD, PhD¹CA4;Xiulan Zhang MD, PhD¹CA5;Xiulan Zhang;Yizhi Liu;Lin Lv （¹State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510623, China;²The three authors contributed equally.;³Mayo Clinic College of Medicine, Rochester, MN 55902, USA;⁴Department of Ophthalmology Center, The First People’s Hospital of Kashi Prefecture, Kashi 844000, China;⁵Rothschild Foundation Hospital, Institut Français de Myopie, Paris, France;⁶Singapore Eye Research Institute, Singapore National Eye Center, Singapore;⁷The International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China;⁸The C-MER Dennis Lam & Partners Eye Center, C-MER International Eye Care Group, Hong Kong, China;⁹Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, LaJolla, CA;¹⁰Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China;¹¹National Clinical Research Center for Ophthalmic Diseases, Shanghai 200080, China;¹²Shanghai Key Laboratory of Fundus Diseases, Shanghai 200080, China）

出处： Ophthalmology 2025

摘要： Purpose To describe the longitudinal changes in peripapillary retinal nerve fiber layer (pRNFL) and macular ganglion cell-inner plexiform layer (mGC-I ...

作者： Jie Mei  ^{1   2}, Zhiwen Luo  ³, Yun Cai  ⁴, Renwen Wan  ³, Zhiwen Qian  ⁵, Jiahui Chu  ^{1   2}, Yaying Sun  ⁶, Yuxin Shi  ⁷, Ying Jiang  ⁸, Yan Zhang  ^{5   8}, Yongmei Yin  ^{1   9   10}, Shiyi Chen  ³ （Affiliations ¹ Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. ² The First Clinical Medicine College, Nanjing Medical University, Nanjing 211166, China. ³ Department of Sports Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China. ⁴ Department of Central Laboratory, Changzhou Jintan First People's Hospital, Jiangsu University, Changzhou 213200, China. ⁵ Departments of Gynecology, Wuxi Maternal and Child Health Care Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi 214023, China. ⁶ Department of Sports Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ⁷ Department of Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Nanjing 211166, China. ⁸ Department of Gynecology, The Obstetrics and Gynecology Hospital Affiliated to Jiangnan University, Wuxi 214023, China. ⁹ Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing 211166, China. ¹⁰ Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 211166, China.）

出处： Research (Washington, D.C.) 2025

摘要： Increasing evidence has shown that physical exercise remarkably inhibits oncogenesis and progression of numerous cancers and exercise-responsive micro ...

作者： Wei Du¹;Chang Xu²;Zhiyuan Cheng³;Zhenyu Sun⁴;Shicheng Guo⁵;Qiang Li⁶;Yuanlin Song⁷;Bo Shen⁸CA1;Yang Bao⁹CA2;Junjie Wu^7,10CA3 （¹College of Basic Medicine, Naval Medical University, Shanghai, China;²Clinical College of Xiangnan University, Chenzhou, China;³Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴Department of Traditional Chinese Medicine, Naval Medical University, Shanghai, China;⁵State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China;⁶Department of Respiratory and Critical Care Medicine, Shanghai East Hospital, Tongji University, Shanghai, China;⁷Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China;⁸The Affilated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, China;⁹Department of Thoracic Surgery, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China;¹⁰Shanghai Geriatric Medical Center, Shanghai, China）

出处： Oncology 2025

关键词： TYMS;rs3819102;Lung cancer;Single nucleotide polymorphism;Prognosis

摘要： Introduction: With high incidence and mortality rates, lung cancer is now one of the most common cancers in the world. The 5-year survival rate of lun ...

作者： Jin-Fu Xu MD^{1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19}CA1;Hui-Zhen Zheng MD^{1,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Hai-Wen Lu MD^{1,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Ling-Wei Wang MD^{20,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Bin Wu MD^{21,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Xiao-Dong Lv MD^{22,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Hong Luo MD^{23,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Jian Feng MD^{24,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Yuan-Yuan Li MD^{25,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Lin Liu MD^{26,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Jin-Guang Jia MD^{27,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Wei-Qiang Mo MD^{28,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Hong-Yan Gu MD^{29,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Jing-Bo Jiang MD^{30,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Dao-Xin Wang MD^{31,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Bin Wang MD^{32,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Li Li MD^{33,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Zhi Yuan MD^{34,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Wen Li MD^{35,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19};Min Xie MD^{36,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19} （¹Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Institute of Respiratory Medicine, School of Medicine, Tongji University, Shanghai, China;²Department of Respiratory and Critical Care Medicine, Huadong Hospital, Fudan University, Shanghai, China;³Contributed equally as first authors;⁴Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Institute of Respiratory Medicine, School of Medicine, Shanghai Jiaotong University, Shanghai, China;⁵Division of Respiratory Medicine and Gastroenterology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK;⁶Department of Respiratory and Critical Care Medicine, The Eighth Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China;⁷Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Ningbo University, Ningbo, China;⁸Department of Pulmonary and Critical Care Medicine, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China;⁹Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China;¹⁰Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China;¹¹State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;¹²Guangzhou National Laboratory, Guangzhou, China;¹³Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China;¹⁴Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;¹⁵Department of Geriatric Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China;¹⁶Department of Respiratory Medicine, Center for Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, State Key Laboratory for Zoonotic Diseases, The First Hospital of Jilin University, Changchun, China;¹⁷Department of Pulmonary and Critical Care Medicine, Anning First People's Hospital Affiliated to Kunming University of Science and Technology, Kunming, China;¹⁸Department of Respiratory Medicine, The Eighth People's Hospital of Shanghai, Shanghai, China;¹⁹Department of Respiratory and Critical Care Medicine, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China;²⁰Department of Respiratory and Critical Care Medicine, Shenzhen People's Hospital, Shenzhen Institute of Respiratory Diseases, Shenzhen, China;²¹Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China;²²Department of Respiratory Medicine, Affiliated Hospital of Jiaxing University, Zhejiang, China;²³Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, China;²⁴Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Nantong Key Laboratory of Respiratory Medicine, Nantong, China;²⁵Department of Respiratory Medicine, Branch of National Clinical Research Center for Respiratory Disease, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China;²⁶Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Immunological Diseases, Guizhou Provincial People's Hospital, Guiyang, China;²⁷Department of Respiratory and Critical Care Medicine, Zhengzhou People's Hospital, Zhengzhou, China;²⁸Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China;²⁹Department of Respiratory Medicine, Affiliated Nantong Hospital of Shanghai University, Nantong, China;³⁰Department of Respiratory and Critical Care Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo, China;³¹Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China;³²Department of Respiratory and Critical Care Medicine, Huzhou Central Hospital, Huzhou Hospital Affiliated to Zhejiang University School of Medicine, Huzhou, China;³³Department of Respiratory and Critical Care Medicine, Baoshan Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;³⁴Department of Respiratory and Critical Care Medicine, Medical Service Community of People's Hospital of Fenghua, Ningbo, China;³⁵Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China;³⁶Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China）

出处： The Lancet Respiratory Medicine 2025

摘要： Background Bronchiectasis is a disease with a global impact, but most published data come from high-income countries. We aimed to describe the clinica ...

作者： Yun Xie¹;Hui Lv¹;Daonan Chen¹;Peijie Huang¹;Zhigang Zhou¹;Ruilan Wang¹CA1 （¹Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, Shanghai 201600, PR China）

出处： IJC Heart & Vasculature 2025

关键词： Sepsis;Acute myocardial injury;CD36

摘要： Background Sepsis-induced myocardial injury (SIMI) is a prevalent form of organ dysfunction with a significant impact on the mortality rate among seps ...

作者： Liwen Zhong^1,2;Danjun Xu²;Jingyi He¹;Lianhui Sun³;Guangjian Fan³;Ting Zhu³;Yufeng Yao¹;Tingting Feng⁴;Zelin Cui² （¹Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;³Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁴Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： International Journal of Medical Microbiology 2025

关键词： Phage JD007;S. aureus;antibodies;therapeutic efficacies;exposure;dermal abscess

摘要： Objectives phage therapy is a promising approach for infections caused by drug-resistant bacteria; this study evaluated the impact of pre-exposure to ...

作者： Dandan Zhao^1,2,3;Huimin Li^1,3;Yongdi Lin¹;Lizhen Liu⁴;Lina Xu¹;Dan Zhang⁵;Yu Fu¹;Jiang Hong¹;Congliang Miao¹CA1 （¹Department of Internal and Emergency Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;²Department of Emergency Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China;³Dandan Zhao and Huimin Li contributed equally to this work.;⁴Department of Pediatrics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China;⁵Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201800, China）

出处： Heart & Lung 2025

摘要： Background Sepsis is a global health challenge with high mortality rates. It demands timely risk identification and biomarker-based strategies to opti ...

作者： Fang Fang¹;Rui Tai²;Fu Yang²;Ran Dong²;Yaqing Zhang^1,3CA1 （¹School of Nursing, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China;²Department of Nursing, Shanghai General Hospital, Shanghai, 200080, China;³ORCID: 0009-0000-6019-0844）

出处： Current Pharmaceutical Analysis 2025

关键词： Gastrointestinal stromal tumor;bioinformatic analysis;drug resistance;metastasis;diagnostic biomarker;immune cell infiltration

摘要： Background Gastrointestinal stromal tumor (GIST) is a prevalent neoplasm in digestive tract, drug resistance and metastasis remain the major challenge ...