作者： Tong Li MD, PhD^1,2,3,4,5,6;Shiqi Yang MD, PhD^1,2,3,4,5,6;Qinghuai Liu MD^7,3,4,5,6;Yanping Song MS^8,3,4,5,6;Jianping Tong MD^9,3,4,5,6;Wenbin Wei MD^10,3,4,5,6;Weiqi Chen BS^11,3,4,5,6;Hong Dai MD^12,3,4,5,6;Wei Wang MS^13,3,4,5,6;Miaoqin Wu MD^14,3,4,5,6;Guohong Zhou MD^15,3,4,5,6;Xuan Xiao MD^16,3,4,5,6;Jinglin Zhang MD^17,3,4,5,6;Rongrong Zhu MS^18,3,4,5,6;Haoyu Li MS^19,3,4,5,6;Yafang Wang PhD^19,3,4,5,6;Xiaoyu Chen PhD^19,3,4,5,6;Shujie Lu MS^19,3,4,5,6;Haiwei Du PhD^19,3,4,5,6;Han Han-Zhang PhD^19,3,4,5,6 （¹Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²T.L. and S.Y. contributed to this study equally.;³Department of Ophthalmology, Huai'an First People's Hospital, Huai'an, China;⁴Department of Fundus Diseases and Surgery, The Affiliated Eye Hospital of Shandong University of Chinese Medicine, Jinan, China;⁵Department of Ophthalmology, The First Bethune Hospital of Jilin University, Changchun, China;⁶Department of Fundus, Weifang Eye Hospital, Weifang, China;⁷Department of Ophthalmology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China;⁸Department of Ophthalmology, General Hospital of Central Theater Command of PLA, Wuhan, China;⁹Department of Ophthalmology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;¹⁰Department of Ophthalmology, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China;¹¹Department of Fundus, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hongkong, Shantou, China;¹²Department of Ophthalmology, Beijing Hospital, Beijing, China;¹³Department of Diabetic Eye Diseases, Hebei Eye Hospital, Xingtai, China;¹⁴Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, China;¹⁵Department of Fundus, Shanxi Eye Hospital, Taiyuan, China;¹⁶Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, China;¹⁷Department of Fundus, Guangzhou Aier Eye Hospital, Guangzhou, China;¹⁸Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, China;¹⁹Department of General Biomedicine, Innovent Biologics Co.. Ltd., Suzhou, China）

出处： Ophthalmology Science 2026

关键词： IBI302;VEGF;Complement;nAMD

摘要： Purpose This study aims to evaluate the efficacy and safety of high-dose efdamrofusp alfa (IBI302, targeting VEGF and complement C3b/4b) with personal ...

作者： Ruijun Cai^1,2;Zhongnan Mao^3,2;Tao An¹;Yunbo Zhang⁴;Li Zhou¹CA1 （¹Department of Pharmacy, Shanghai General Hospital Jiuquan Hospital (The People's Hospital of Jiuquan), Jiuquan, GanSu 735000, China;²These authors have contributed equally to this work and share first authorship;³Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, GanSu 730000, China;⁴Gansu University of Chinese Medicine, Lanzhou, GanSu 730000, China）

出处： Journal of Chromatography B 2026

关键词： Byakangelicin;Metabolites;In vivo;UHPLC-Q-exactive orbitrap MS;Sprague-Dawley rats

摘要： Byakangelicin is a furanocoumarin derived from the roots of Angelica dahurica. It exhibits pharmacological properties, including anti-tumor activity, ...

作者： Yuan Liu¹, Jian Sun¹, Yanmei Hu¹, Yu Wu¹, Yixia Yang¹ （Affiliation ¹ Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.）

出处： Clinical and experimental reproductive medicine 2026

关键词： Birth weight;Estrogen vaginally;Frozen-thawed embryo transfer;Hormone replacement;Live birth.

摘要： Objective: Previous studies have reported a higher rate of small for gestational age (SGA) newborns from fresh embryo transfers compared with frozen-t ...

作者： Xixi Hou^1,2;Shuxiang Xu³CA1;Longfei Mao^4,5;Yue-Ming Li⁵;Jianji Wang¹CA2 （¹Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P.R. China;²The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan 471003, P.R. China;³Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, P.R. China;⁴College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Henan 471000, P.R. China;⁵State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300350, P.R. China）

出处： Bioorganic & Medicinal Chemistry Letters 2026

关键词： 1,2,3-Triazole;Antitumor;DNA damage;Prostate Cancer cells;Stanolone.

摘要： 1,2,3-Triazole skeleton may act as both a hydrogen bond acceptor and a linker connecting different structures, and androgens bearing 1,2,3-triazole st ...

作者： Dongxiao Qu^1,2,3;Yudan Zhu^2,3;Ziyu Guo⁴;Shuzhang Zhang⁴;Yu Yao⁵;Wei Wu⁶;Lu Zhao^2,7;Yunqing Zeng²;Yangbo Hou²;Wenhai Xiang¹;Chao Wang¹;Cuina Yan²;Lele Tang²;Yonghua Ji⁴;Yiqin Ge⁸CA1;Jiwei Cheng²CA2;Jie Tao^1,2,4CA3,4 （¹Nanxiang Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201802, China;²Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China;³Dongxiao Qu and Yudan Zhu contributed equally to this work.;⁴Joint Laboratory of Nanxiang Branch of Ruijin Hospital-School of Life Sciences, Shanghai University, Shanghai, 200444, China;⁵Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China;⁶Department of Pharmacy, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China;⁷Shanghai Clinical College, Anhui Medical University, Shanghai, 200062, China;⁸Department of Neurosurgery, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201803, China）

出处： Journal of Ethnopharmacology 2026

摘要： Ethnopharmacological relevance Epilepsy is the fourth most common neurological disorder, and nearly 30 % of patients develop seizures that are refract ...

作者： Qian Wang¹;Weiquan Wang²;Haihong Zhu¹;Yangguang Huang²;Rongkun Huang²;Yunlong Yang³;Yun Liao³CA1 （¹Department of Pharmacy, Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China;²Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China;³Shanghai general hospital, Shanghai, 200080, China）

出处： Phytomedicine 2026

关键词： Ferroptosis;HMOX1;Multiple cerebral concussion;Naozhenning;Recurrent mild traumatic brain injury.

摘要： Background Recurrent mild traumatic brain injury (rmTBI) represent a significant predisposing factor for the development of neurodegenerative diseases ...

作者： Ming Ma^1,2;Shuo Lian^1,3,2;Patricia Kraft¹;Tobias Mayer¹;Alex Ali Sayour^1,4;Matthias Karck¹;Gábor Szabó^1,5;Sevil Korkmaz-Icöz^1,5CA1 （¹Department of Cardiac Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany;²Contributed equally.;³Department of Vascular Surgery, General Surgery Clinical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 200080 Shanghai, China;⁴Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary;⁵Department of Cardiac Surgery, University Hospital Halle (Saale), 06120 Halle, Germany）

出处： Biochemical Pharmacology 2026

关键词： Ischemia/reperfusion injury;Canagliflozin;Endothelial function;Coronary artery bypass

摘要： Ischemia/reperfusion (IR) injury during coronary artery bypass grafting surgery has detrimental impacts on endothelial integrity and function. Studies ...

作者： Bingbing Feng^1,2;Yuxin Chen^3,2;Haizhou Fu^4,2;Yufei Li⁵;Jingjing Guo⁵;Xixi Hou^6,7CA1;Huibin Xu^8,9CA2;Shuxiang Xu^10,11CA3 （¹School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210046, China;²These authors contributed equally to this work.;³Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, China;⁴School of Stomatology, Zhejiang Chinese Medical University, Hangzhou, 310053, China;⁵Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao Special Administrative Region of China;⁶School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan, 453007, China;⁷The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, Henan, 471003, China;⁸Precision Research Center for Refractory Diseases, Shanghai Jiao Tong University Pioneer Research Institute for Molecular and Cell Therapies, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China;⁹State Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai, 200240, China;¹⁰Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China;¹¹College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, China）

出处： European Journal of Medicinal Chemistry 2026

关键词： Ferroptosis;GPX4;Melanoma;Triazole-benzoxazine.

摘要： Melanoma, a highly metastatic cancer with rising incidence, faces therapeutic challenges due to drug resistance and recurrence. In this study, we desi ...

作者： Jiachang Hong¹, Penghao Ji¹, Jinxi An¹, Junchao Huang¹, Ziheng Bu¹, Xudong Zhang¹, Wei Liu¹, Tingyu Wu¹, Sen Wang¹, Wei Zhu¹, Yuhui Li¹, Jixian Wan¹, Sudan Xu², Minfeng Huo¹, Peng Wu¹ （Affiliations ¹ Department of Orthopedics, Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, The Institute for Biomedical Engineering & Nano Science, School of Medicine, Tongji University, Shanghai, P. R. China. ² Department of Geriatric, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.）

出处： Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026

关键词： anti‐inflammatory;macrophage reprogramming;myricetin‐arginine conjugate nanozymes;osteoclastogenesis;rheumatoid arthritis.

摘要： Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and progressive joint destruction driven by macropha ...

作者： Lingfeng Yu^1,2,3;Qi Wu^4,3;Fei Jin^5,3;Yixin Zhang^6,3;Mengpan Li^1,3;Negar Javanmardi⁵;Hao Zhu⁷;Yu Wang⁵;Xin Yu²;Guangxin Zhou²;Jianda Xu⁸CA1;Jianning Zhao²CA2;Zhang-Qi Feng⁵CA3;Ting Wang⁶CA4 （¹Department of Orthopedic Oncology, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China;²Department of Orthopedics, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, PR China;³Authors contributed equally to this work.;⁴Department of Vascular Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, PR China;⁵School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, PR China;⁶State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, 210096, PR China;⁷School of Life Sciences, Nanjing University, Nanjing, 210033, Jiangsu, PR China;⁸Department of Orthopedics, Changzhou Hospital of Traditional Chinese Medicine, Changzhou Hospital Affiliated to Nanjing University of Chinese Medicine, Changzhou, 213003, PR China）

出处： Biomaterials 2026

关键词： Bionic electric signals;Bone regeneration;Metabolic reprogramming;Self-sustained bioelectronic system.

摘要： Bionic bioelectronics has promising applications in bone defect repair, with current research primarily focusing on the development of electroactive b ...