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作者: Haiming Zheng #  1, Meiying Zhu #  1, Wenhua Li  2, Zunqiang Zhou  3, Xinjian Wan  1 (Affiliations 1 Digestive Endoscopic Center, Shanghai Jiao Tong University Affiliated Sixth People\'s Hospital. 2 Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai JiaoTong University School of Medicine. 3 Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People\'s Hospital.)

出处: Liver international : official journal of the International Association for the Study of the Liver 2022

关键词: METTL3;NSUN2;RNA methylation;YAP1;ceRNA.

摘要: Cholangiocarcinoma (CCA) is a severe malignancy originating from the bile duct and the second most common primary liver cancer. NF-kappa B interacting ...

作者: Kaige Ma  1, Donghua Huang  1, Chunqing Meng  1, Hong Wang  1, Zengwu Shao  1, Huimin Liu  2, Dehao Fu  1   3 (Affiliations 1 Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland). 2 Department of Internal Emergency Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland). 3 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (mainland).)

出处: Medical science monitor : international medical journal of experimental and clinical research 2022 Vol.28 Pe934488

摘要: BACKGROUND Open distal humeral fractures (DHFs) often lead to loss of elbow function, thereby seriously affecting patient quality of life. The aim of ...

作者: Louis Wing-Cheong Chow  1   2, Pei-Fen Fu  3, Lei Guo  4, Xi-Chun Hu  5, Jun Jiang  6, Erich Ferdiansyah Lie  1, Jian Liu  7, Xiao-Hong Lu  2, Yong-Kui Lu  8, Hong-Min Ma  9, Qin-Guo Mo  10, Yan-Xia Shi  11, Kun Wang  12   13, Ming-Hao Wang  6, Shu Wang  14, Shu-Sen Wang  15, Xian-Ming Wang  16, Xiao-Jia Wang  17, Hui-Jing Wu  18, Hong-Jian Yang  19, He-Rui Yao  20, Yi Zhang  6, Li Zhu  21, - On Behalf Of The Asian Institute Of Clinical Oncology Aico Expert Panel (Affiliations 1 UNIMED Medical Institute, Hong Kong SAR, China. 2 Organisation for Oncology and Translational Research, Hong Kong SAR, China. 3 Department of Breast Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China. 4 Department of Burn and Plastic Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 5 Department of Medical Oncology, Fudan University Shanghai Cancer Center, Xuhui District, Shanghai, China. 6 Breast Disease Centre, Southwest Hospital, Third Military Medical University, Chongqing, China. 7 Department of Breast Medical Oncology, Fujian Provincial Tumor Hospital, Fuzhou, China. 8 The Department of Breast and Bone Tissue Oncology, Affiliated Tumor Hospital of Guangxi Medical University, China. 9 Department of Breast Surgery, Guangzhou Women and Children\'s Medical Center, Guangzhou, China. 10 Department of Breast Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China. 11 Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. 12 Department of Breast Cancer, Cancer Center, Guangdong Provincial People\'s Hospital and Guangdong Academy of Medical Sciences, Guangzhou, China. 13 The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China. 14 Breast Center, Peking University People\'s Hospital, Beijing, China. 15 Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China. 16 Department of Thyroid and Breast Surgery, Shenzhen Second People\'s Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China. 17 Department of Breast Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences / Zhejiang Cancer Hospital/Institute of Cancer and Basic Medicine (ICBM), Chinese Academy of Sciences, Hangzhou, China. 18 Department of Medical Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. 19 Department of Breast Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China. 20 Department of Oncology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. 21 Department of Thyroid and Breast Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.)

出处: Asian Pacific journal of cancer prevention : APJCP 2022 Vol.23 No.2 P379-382

关键词: China;Questionnaire;breast cancer;perceived importance;risk factor.

摘要: There are varying definitions of women at high risk of breast cancer across different institutions, and there are reports suggesting that the breast c ...

作者: Yafang Wang  1, Yang Liu  1, Shu Liu  1, Xiaomeng Li  1, Xinxin Liu  1   2, Ming Jiao  3, Yuqin Yang  3, Xueting Luo  1   2, Fenghua Wang  1   2   4   5   6, Xiaoling Wan  1   2, Xiaodong Sun  1   2   4   5   6 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, China200080. 2 Shanghai Key Laboratory of Ocular Fundus Diseases, 100 Haining Road, Shanghai, China200080. 3 Laboratory Animal Center, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Road, Shanghai, China201620. 4 Shanghai Engineering Center for Visual Science and Photomedicine, 100 Haining Road, Shanghai, China200080. 5 National Clinical Research Center for Eye Diseases, 100 Haining Road, Shanghai, China200080. 6 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, 100 Haining Road, Shanghai, China200080.)

出处: Disease models & mechanisms 2022 Vol.15 No.3 Pdmm049222

关键词: Cyp4v3;Bietti crystalline dystrophy;Lipid accumulation;Mouse model;Retinal degeneration.

摘要: Bietti crystalline dystrophy (BCD) is an autosomal recessive inherited retinal disease, resulting in blindness in most patients. The etiology and deve ...

作者: Mengmeng Jiang  1, Hai Xie  2, Chaoyang Zhang  3   4, Tianqin Wang  1, Haibin Tian  2, Lixia Lu  2, Jing-Ying Xu  2, Guo-Tong Xu  2, Lin Liu  1, Jingfa Zhang  3   4 (Affiliations 1 Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, China. 4 National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China.)

出处: Journal of cellular and molecular medicine 2022

关键词: diabetic retinopathy;fractalkine;microglia;neuroinflammation.

摘要: The concept of diabetic retinopathy (DR) has been extended from microvascular disease to neurovascular disease in which microglia activation plays a r ...

作者: Yumeng Zhang  1, Zhenzhen Zhao  1, Xiaohuan Zhao  1, Hai Xie  2, Chaoyang Zhang  1, Xiaodong Sun  3, Jingfa Zhang  4 (Affiliations 1 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. 2 Tongji Eye Institute, Department of Regenerative Medicine, and Department of Pharmacology, Tongji University School of Medicine, Shanghai, China. 3 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: xdsun@sjtu.edu.cn. 4 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University, Shanghai, 200080, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, 200080, China. Electronic address: jingfa.zhang@shgh.cn.)

出处: Free radical biology & medicine 2022 Vol.181 P14-28

关键词: HMGB2;Oxidative stress;Photoreceptor;Pyroptosis;Retinal degeneration.

摘要: In the pathogenesis of retinal degenerative diseases, oxidative stress is a key driver leading to photoreceptor death and eventually vision loss. Curr ...

作者: Ying Cao #  1, Ye Tian #  2   3, Heng Zhang  2, Guang-Heng Luo  2, Zhao-Lin Sun  2, Shu-Jie Xia  4 (Affiliations 1 Guizhou University School of Medicine, Guiyang, 550025, Guizhou, China. 2 Department of Urology, Guizhou Provincial People\'s Hospital, Guiyang, 550002, Guizhou, China. 3 Department of Urology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. 4 Department of Urology, Shanghai First People\'s Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. xsj4017@163.com.)

出处: International urology and nephrology 2022 Vol.54 No.3 P499-508

关键词: LUTS;Prostate fibrosis;Sex hormone;TGF-β/Smad signaling pathway.

摘要: Objective: The present study aimed to investigate the effects of an imbalance in the estrogen/androgen ratio on prostate fibrosis. Methods: Different ...

作者: Kaiyuan Liu  1, Yuxin Liao  1, Dong Yang  1, Tianyang Xu  1, Qiuming Gao  1, Wenwei Jiang  1, Lin Fan  1, Pengfei Zan  2, Guodong Li  1 (Affiliations 1 Department of Orthopedics, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, China. 2 Department of Orthopedics, Shanghai First People\'s Hospital, Jiaotong University School of Medicine, Shanghai, China.)

出处: Frontiers in surgery 2022 Vol.9 P692072

关键词: MIS-TKA;clinical effectiveness;gap balance;patellar position;soft tissue balance.

摘要: Background: We hypothesized that subluxating patellar during minimally invasive total knee arthroplasty (MIS-TKA) would affect intraoperative soft tis ...

作者: Kepeng Ou  1, Youjian Li  1, Ling Liu  2, Hua Li  2, Katherine Cox  3, Jiahui Wu  4, Jian Liu  3, Andrew D Dick  5 (Affiliations 1 College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing, China; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. 2 Department of Ophthalmology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China. 3 Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. 4 Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK; Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol; Institute of Ophthalmology, University College London, London; National Institute for Health Research Biomedical Research Centre, Moorfields Eye Hospital, London, UK.)

出处: Neural regeneration research 2022 Vol.17 No.9 P1919-1928

关键词: antioxidants;autophagy enhancers;complement inhibitors;exosomes;neuropeptides;neuroprotective agents;retinal degeneration;senolytics.

摘要: Retinal degeneration is a debilitating ocular complication characterized by the progressive loss of photoreceptors and other retinal neurons, which ar ...

作者: Shu Yang  1, Bing-Cheng Wu  1, Zhe Cheng  2, Lan Li  3, Yuan-Ping Zhang  4, Hui Zhao  5, Han-Mei Zeng  1, Dong-Fang Qi  1, Zi-Yao Ma  1, Jian-Guo Li  1, Rui Han  1, Fang-Zhou Qu  1, Yan Luo  6, Yi Liu  7, Xiao-Lei Chen  8, Hong-Mei Dai  1 (Affiliations 1 Department of Ophthalmology, The First Hospital of Kunming, Kunming, 650011 Yunnan Province, China. 2 Eye institute of Xiamen University, Xiamen, Fujian, China. 3 Department of Ophthalmology, The Calmette Affiliated Hospital of Kunming Medical University, Kunming, China. 4 Department of Ophthalmology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China. 5 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People\'s Hospital), Shanghai 200080, China. 6 Department of Pediatrics, The First Hospital of Kunming, Kunming, 650011 Yunnan Province, China. 7 Department of Otorhinolaryngology, The First Hospital of Kunming, Kunming, 650011 Yunnan Province, China. 8 Department of Endocrinology, The First Hospital of Kunming, Kunming, 650011 Yunnan Province, China.)

出处: Disease markers 2022 Vol.2022 P7550090

摘要: Objective: The aims of our experiment were to compare the microorganisms in meibomian gland secretions from patients with internal hordeolum before an ...

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