作者： Tong Li MD, PhD^1,2,3,4,5,6;Shiqi Yang MD, PhD^1,2,3,4,5,6;Qinghuai Liu MD^7,3,4,5,6;Yanping Song MS^8,3,4,5,6;Jianping Tong MD^9,3,4,5,6;Wenbin Wei MD^10,3,4,5,6;Weiqi Chen BS^11,3,4,5,6;Hong Dai MD^12,3,4,5,6;Wei Wang MS^13,3,4,5,6;Miaoqin Wu MD^14,3,4,5,6;Guohong Zhou MD^15,3,4,5,6;Xuan Xiao MD^16,3,4,5,6;Jinglin Zhang MD^17,3,4,5,6;Rongrong Zhu MS^18,3,4,5,6;Haoyu Li MS^19,3,4,5,6;Yafang Wang PhD^19,3,4,5,6;Xiaoyu Chen PhD^19,3,4,5,6;Shujie Lu MS^19,3,4,5,6;Haiwei Du PhD^19,3,4,5,6;Han Han-Zhang PhD^19,3,4,5,6 （¹Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²T.L. and S.Y. contributed to this study equally.;³Department of Ophthalmology, Huai'an First People's Hospital, Huai'an, China;⁴Department of Fundus Diseases and Surgery, The Affiliated Eye Hospital of Shandong University of Chinese Medicine, Jinan, China;⁵Department of Ophthalmology, The First Bethune Hospital of Jilin University, Changchun, China;⁶Department of Fundus, Weifang Eye Hospital, Weifang, China;⁷Department of Ophthalmology, The First Affiliated Hospital With Nanjing Medical University, Nanjing, China;⁸Department of Ophthalmology, General Hospital of Central Theater Command of PLA, Wuhan, China;⁹Department of Ophthalmology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;¹⁰Department of Ophthalmology, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China;¹¹Department of Fundus, Joint Shantou International Eye Center of Shantou University and The Chinese University of Hongkong, Shantou, China;¹²Department of Ophthalmology, Beijing Hospital, Beijing, China;¹³Department of Diabetic Eye Diseases, Hebei Eye Hospital, Xingtai, China;¹⁴Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, China;¹⁵Department of Fundus, Shanxi Eye Hospital, Taiyuan, China;¹⁶Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, China;¹⁷Department of Fundus, Guangzhou Aier Eye Hospital, Guangzhou, China;¹⁸Department of Ophthalmology, Affiliated Hospital of Nantong University, Nantong, China;¹⁹Department of General Biomedicine, Innovent Biologics Co.. Ltd., Suzhou, China）

出处： Ophthalmology Science 2026

关键词： IBI302;VEGF;Complement;nAMD

摘要： Purpose This study aims to evaluate the efficacy and safety of high-dose efdamrofusp alfa (IBI302, targeting VEGF and complement C3b/4b) with personal ...

作者： Ruijun Cai^1,2;Zhongnan Mao^3,2;Tao An¹;Yunbo Zhang⁴;Li Zhou¹CA1 （¹Department of Pharmacy, Shanghai General Hospital Jiuquan Hospital (The People's Hospital of Jiuquan), Jiuquan, GanSu 735000, China;²These authors have contributed equally to this work and share first authorship;³Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, GanSu 730000, China;⁴Gansu University of Chinese Medicine, Lanzhou, GanSu 730000, China）

出处： Journal of Chromatography B 2026

关键词： Byakangelicin;Metabolites;In vivo;UHPLC-Q-exactive orbitrap MS;Sprague-Dawley rats

摘要： Byakangelicin is a furanocoumarin derived from the roots of Angelica dahurica. It exhibits pharmacological properties, including anti-tumor activity, ...

作者： Xixi Hou^1,2;Shuxiang Xu³CA1;Longfei Mao^4,5;Yue-Ming Li⁵;Jianji Wang¹CA2 （¹Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, P.R. China;²The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Henan 471003, P.R. China;³Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, P.R. China;⁴College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Henan 471000, P.R. China;⁵State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin 300350, P.R. China）

出处： Bioorganic & Medicinal Chemistry Letters 2026

关键词： 1,2,3-Triazole;Antitumor;DNA damage;Prostate Cancer cells;Stanolone.

摘要： 1,2,3-Triazole skeleton may act as both a hydrogen bond acceptor and a linker connecting different structures, and androgens bearing 1,2,3-triazole st ...

作者： Dongxiao Qu^1,2,3;Yudan Zhu^2,3;Ziyu Guo⁴;Shuzhang Zhang⁴;Yu Yao⁵;Wei Wu⁶;Lu Zhao^2,7;Yunqing Zeng²;Yangbo Hou²;Wenhai Xiang¹;Chao Wang¹;Cuina Yan²;Lele Tang²;Yonghua Ji⁴;Yiqin Ge⁸CA1;Jiwei Cheng²CA2;Jie Tao^1,2,4CA3,4 （¹Nanxiang Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201802, China;²Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China;³Dongxiao Qu and Yudan Zhu contributed equally to this work.;⁴Joint Laboratory of Nanxiang Branch of Ruijin Hospital-School of Life Sciences, Shanghai University, Shanghai, 200444, China;⁵Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China;⁶Department of Pharmacy, First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China;⁷Shanghai Clinical College, Anhui Medical University, Shanghai, 200062, China;⁸Department of Neurosurgery, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201803, China）

出处： Journal of Ethnopharmacology 2026

摘要： Ethnopharmacological relevance Epilepsy is the fourth most common neurological disorder, and nearly 30 % of patients develop seizures that are refract ...

作者： Lingfeng Yu^1,2,3;Qi Wu^4,3;Fei Jin^5,3;Yixin Zhang^6,3;Mengpan Li^1,3;Negar Javanmardi⁵;Hao Zhu⁷;Yu Wang⁵;Xin Yu²;Guangxin Zhou²;Jianda Xu⁸CA1;Jianning Zhao²CA2;Zhang-Qi Feng⁵CA3;Ting Wang⁶CA4 （¹Department of Orthopedic Oncology, Shanghai Bone Tumor Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, PR China;²Department of Orthopedics, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, PR China;³Authors contributed equally to this work.;⁴Department of Vascular Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, PR China;⁵School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, PR China;⁶State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, 210096, PR China;⁷School of Life Sciences, Nanjing University, Nanjing, 210033, Jiangsu, PR China;⁸Department of Orthopedics, Changzhou Hospital of Traditional Chinese Medicine, Changzhou Hospital Affiliated to Nanjing University of Chinese Medicine, Changzhou, 213003, PR China）

出处： Biomaterials 2026

关键词： Bionic electric signals;Bone regeneration;Metabolic reprogramming;Self-sustained bioelectronic system.

摘要： Bionic bioelectronics has promising applications in bone defect repair, with current research primarily focusing on the development of electroactive b ...

作者： Hongmei Liang RD, MSN¹;Long Liu MD²CA1 （¹Department of Nursing, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China;²Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China）

出处： Australian Critical Care 2026

作者： Ruoyao Yu  ¹, Mengru Fang  ², Hao Xu  ³, Fance Meng  ⁴, Ning Tang  ⁵, Xinyu Liu  ⁶, Shaoqing Feng  ⁷, Kan Wang  ⁸, Jinhong Guo  ⁹ （Affiliations ¹ School of Automation and Intelligent Sensing, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: yry_0816@sjtu.edu.cn. ² School of Automation and Intelligent Sensing, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: fangmengru@sjtu.edu.cn. ³ School of Naval Architecture, Ocean & Civil Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: xudahao@sjtu.edu.cn. ⁴ School of Automation and Intelligent Sensing, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: 2368187105@sjtu.edu.cn. ⁵ Precision Research Center for Refractory Diseases in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, China. Electronic address: ntang@sjtu.edu.cn. ⁶ School of Automation and Intelligent Sensing, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: liuxinyu_sjtu@163.com. ⁷ Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. Electronic address: fmmufsq@163.com. ⁸ School of Automation and Intelligent Sensing, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: wk_xa@163.com. ⁹ School of Automation and Intelligent Sensing, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address: guojinhong@sjtu.edu.cn.）

出处： Biosensors & bioelectronics 2026

关键词： Electrochemical immunosensor;Hormone detection;MXene;Microfluidic;Progesterone;Saliva testing.

摘要： Progesterone (P4) levels serve as an essential indicator for assessing pregnancy status. The traditional serum testing methods are limited in clinical ...

作者： Zeze Fu^1,2;Qingyu Liu^3,2;Yicheng Zhao⁴;Yueshan Xu⁵;Bingmei Wang⁵;Li Wang^4,5CA1;Runze Li⁴CA2;Liang Zhu¹CA3 （¹Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China;²These authors contributed equally.;³Department of Ophthalmology, Shanghai Children’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;⁴Chinese Medicine Guangdong Laboratory /State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Clinical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong, China;⁵Changchun University of Chinese Medicine, Changchun 130117, China）

出处： Biochemical Pharmacology 2026

摘要： Antimicrobial resistance in Staphylococcus aureus, especially methicillin resistant strains, contributes to severe pneumonia and septic arthritis and ...

作者： Yun Bai ^{#  1}, Zi-Chen An ^{#  1}, Lian-Fang Du  ¹, Fan Li  ², Ying-Yu Cai  ³ （Affiliations ¹ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² Department of Ultrasound, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. medicineli@sjtu.edu.cn. ³ Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. yingyu.cai@shgh.cn.）

出处： Journal of imaging informatics in medicine 2025

关键词： Contrast-enhanced ultrasound;Deep learning;Renal tumor;Subtype classification.

摘要： The purpose of this study is to assess the ability of deep learning models to classify different subtypes of solid renal parenchymal tumors using cont ...

作者： Jun-Hua Ji  ¹, Min Yang  ², Yan Jiang  ³, Ting-Xian Yang  ¹, Xiao-Jing Ma  ¹, Qi-Chao Yin  ¹, Hong-Wei Yin  ¹, Lin-Hua Ji  ⁴ （Affiliations ¹ Department of Nuclear Medicine, The Affiliated Hospital of Qinghai University, Xining 810001, Qinghai Province, China. ² Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. ³ Research Center for High Altitude Medicine, Qinghai University, Xining 810001, Qinghai Province, China. ⁴ Department of Hematology, Huadu District People's Hospital of Guangzhou, Guangzhou 510800, Guangdong Province, China.）

出处： Zhongguo shi yan xue ye xue za zhi 2025

关键词： high-altitude polycythemia;epigenetics;DNA methylation;functional and pathway enrichment analysis.

摘要： Objective: To investigate the whole-genome differential methylation profile of patients with high-altitude polycythemia (HAPC). Methods: In this study ...