作者： Guangze Shao  ¹, Jitu Xu  ¹, Chencheng Hu  ¹, Wenyao Jia  ¹, Xitong Xu  ¹, Yue Gu  ¹, Luming Zhang  ², Zhihuang Zheng  ³, Jiayan Zhong  ¹, Siqi Zhu  ¹, Shenghao Meng  ¹, Zhonghua Zhao  ¹, Zhigang Zhang  ¹, Jun Liu  ³, Yanyong Xu  ^{4   5}, Huijuan Wu  ¹ （Affiliations ¹ Department of Pathology of School of Basic Medical Sciences, Fudan University, Kidney and Dialysis Institute of Shanghai, Shanghai, PR China. ² School of Biological Sciences, College of Life Science, Northwest A&F University, Xianyang, PR China. ³ Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China. ⁴ Frontier Innovation Center of School of Basic Medical Sciences, Fudan University, Shanghai, PR China. ⁵ Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Pathology of School of Basic Medical Sciences, Fudan University, Shanghai, PR China.）

出处： The Journal of pathology 2025

关键词： TEAD3;YAP;focal segmental glomerulosclerosis (FSGS);podocyte adhesion;α3β1 integrin.

摘要： Severe proteinuria in focal segmental glomerulosclerosis (FSGS) is closely associated with decreased adhesion, and subsequent loss, of podocytes. Yes- ...

作者： Yiwei Wu  ^{1   2}, Ying Xiao  ³, Lipu Cui  ^{1   2}, Xinran Qin  ^{1   2}, Shuli Chen  ^{1   2}, Qingyu An  ^{1   2}, Tianyi Yuan  ^{1   2}, Qiurong Lin  ⁴, Haidong Zou  ^{1   2   4}, Xiangui He  ⁴, Chenhao Yang  ³, Peiyao Jin  ^{1   2} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ² National Clinical Research Centre for Eye Diseases, Shanghai Clinical Research Centre for Eye Diseases, Shanghai Key Clinical Specialty, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Centre for Visual Science and Photomedicine, Shanghai Engineering Centre for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. ³ Department of Ophthalmology, Children's Hospital of Fudan University, Shanghai, China. ⁴ Shanghai Eye Diseases Prevention and Treatment Centre, Shanghai Eye Hospital, Shanghai, China.）

出处： Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 2025

关键词： choroidal thickness;diabetic retinopathy;retinal thickness;swept‐source optical coherence tomography;type 1 diabetes mellitus.

摘要： Purpose: To explore the longitudinal changes in retinal and choroidal thickness and their relation with the onset of type 1 diabetes mellitus (T1DM) i ...

作者： Yiming Yang  ¹, Xiaoyan Hu  ², Liu Yang  ³, Hongai Zhang  ⁴, Honghao Zheng  ⁵, Zhenxing Shen  ⁶ （Affiliations ¹ Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China; Key Lab of Aerosol Chemistry & Physics, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, 710049, China. ² Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China. ³ Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China; Key Lab of Aerosol Chemistry & Physics, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, 710049, China. Electronic address: yangliu2013@xjtu.edu.cn. ⁴ Department of Neonatology, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 650 Xinsongjiang Rd, Songjiang District, Shanghai 201620, China. ⁵ Key Lab of Aerosol Chemistry & Physics, SKLLQG, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an, 710049, China. ⁶ Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China. Electronic address: zxshen@mail.xjtu.edu.cn.）

出处： Environmental pollution (Barking, Essex : 1987) 2025

关键词： Airborne bacterial community;Co-occurrence analysis;PM(2.5);Potential pathogenic bacteria;STAMP analysis.

摘要： Bioaerosols significantly influence air quality and human health. This study investigated the diversity, structure, and interaction of bacterial commu ...

作者： Yisheng Chen  ¹, Zhongcheng Fan  ², Zhiwen Luo  ¹, Xueran Kang  ³, Renwen Wan  ¹, Fangqi Li  ¹, Weiwei Lin  ⁴, Zhihua Han  ⁵, Beijie Qi  ¹, Jinrong Lin  ¹, Yaying Sun  ¹, Jiebin Huang  ⁶, Yuzhen Xu  ⁷, Shiyi Chen  ¹ （Affiliations ¹ Department of Sport Medicine, Huashan Hospital, Fudan University, Shanghai, China. ² Department of Orthopedic Surgery, Hainan Province Clinical Medical Center, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, Hainan Province, China. ³ Department of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China. ⁴ Department of Neurosurgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China. ⁵ Department of Orthopedics, Shanghai General Hospital, School of Medicine Shanghai Jiao Tong University, Shanghai, China. ⁶ Department of Infectious Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China. ⁷ Department of Rehabilitation, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong Province, China.）

出处： Neural regeneration research 2025

摘要： JOURNAL/nrgr/04.03/01300535-202504000-00029/figure1/v/2024-07-06T104127Z/r/image-tiff Recent research has demonstrated the impact of physical activity ...

作者： Hui Wang¹;Zijian Wang¹;Jin Ma²;Jian Chen³;Hong Li¹;Weiju Hao¹;Qingyuan Bi¹;Shuning Xiao¹;Jinchen Fan¹CA1;Guisheng Li^1,2 （¹School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China;²Department of Chemistry, Shanghai Normal University, 100 Guilin Rd., Shanghai 200234, China;³Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China）

出处： Journal of Colloid and Interface Science 2025

摘要： As a kind of promising oxygen evolution reaction (OER) catalysts, metal–organic frameworks (MOF) are often constrained by their inherent poor electroc ...

作者： Xiao-Yu Wu^1,2;Shi Peng^1,2;Xin-Tao Li^3,2;Song-Wen Chen¹;Yong Wei¹;Yu-Tong Ye¹;Chang-Zuan Zhou¹;Zi-Kan Zhong¹;Long-Zhe Gao¹;Chen-Yang Jin¹;De-Ping Kong⁴;Shao-Wen Liu¹CA1;Gen-Qing Zhou¹CA2 （¹Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China;²These authors contributed equally to this work.;³Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China;⁴Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200000, China）

出处： Biochimica et Biophysica Acta - Molecular Basis of Disease 2025

关键词： PFKP;Hypertrophy;Myocyte, cardiac;EIF2S2;Protein synthesis

摘要： Metabolic reprogramming precedes most alterations during pathological cardiac hypertrophy and heart failure (HF). Recent studies have revealed that Ph ...

作者： Kainan Guo¹;Kangkang Ou¹CA1;Md All Amin Newton¹;Jun Zhang¹;Hui Xu²;Jinyi Li¹;Binjie Xin¹CA2;Yinjun Huang³CA3 （¹School of Textiles and Fashion, Shanghai University of Engineering Science, Shanghai 201620, PR China;²Henan Key Laboratory of Medical and Protective Products, Xinxiang 453400, PR China;³Department of Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, PR China）

出处： Journal of Colloid and Interface Science 2025

摘要： Chronic wounds often produce a significant volume of exudate, posing a substantial obstacle to healing. Consequently, there is a pressing demand for a ...

作者： Zhong Chen^1,2;Da-Wei Geng²;Tang-Bo Yuan²;Chen Yu²;Da-Wei Cai²;Yong Yin³CA1;Qiang Shen¹CA2 （¹Department of Orthopaedics, Shanghai General Hospital of Nanjing Medical University, Shanghai, China;²Department of Orthopaedics, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China;³Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China）

出处： Bioorganic & Medicinal Chemistry Letters 2025

摘要： Novel N-substituent diphenylamine derivatives as tubulin inhibitors targeting colchicine-binding site have been designed based on structural simplific ...

作者： Min Tang^1,2,3;Xiaohui Wei^1,3;Yunqin Ma^1,3;Yijiong Tan⁴;Han Cao^5,6;Shuangshuang Yao¹;Jiaqi Wang¹;Hua Yang²;Fang Liu¹;Yongde Peng^1,5CA1;Nengguang Fan¹CA2 （¹Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;²Department of Endocrinology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China;³These authors contributed equally to this work.;⁴Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;⁵Department of Endocrinology and Metabolism, Shanghai General Hospital of Nanjing Medical University, Shanghai, China;⁶Department of Endocrinology, Songjiang District Central Hospital, Shanghai, China）

出处： Life Sciences 2025

摘要： Objective The role of ubiquitin-specific protease 13 (USP13) in metabolic dysfunction-associated steatohepatitis (MASH) remains unclear. This study ai ...

作者： Meng Gu  ¹, Jiajun Fang  ², Zhongmei Shao  ³, Hui Yu  ¹, Senchao Guo  ¹, Yang Gao  ¹, Xiaojin He  ⁴, Yuping Xu  ⁵, Mingrong Lv  ⁶ （Affiliations ¹ Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China. ² The First Clinical Medical College of Anhui Medical University, Hefei 230032, China. ³ Anhui No. 2 Provincial People's Hospital, Hefei, Anhui 230012, China. ⁴ NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁵ Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address: allin0701@126.com. ⁶ Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei, Anhui 230022, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei, Anhui 230032, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei, Anhui 230032, China. Electronic address: lvmingrong2016@163.com.）

出处： Gene 2025

关键词： Assisted reproductive technology;ERCC6;FOXL2;Female infertility;Premature ovarian insufficiency.

摘要： Premature ovarian insufficiency (POI) is the main cause of infertility in women. Some cases of POI are thought to be caused by genetic defects and the ...