作者： Chen Guo  ¹, Randy Donelson  ¹, Zhengyu Wang  ², Amanda Billups  ³, Tongjia Liu  ⁴, Emma Torii  ⁵, Danielle Burroughs  ⁶, Marcus Flowers  ³, Asheesh Shukla  ⁴, Ryan Jeo  ⁴, Davis Seelig  ⁵, Chun Wang  ³, Jafar Golzarian  ¹ （Affiliations ¹ Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, United States. ² Vascular and Interventional Radiology Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. ³ Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States. ⁴ Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States. ⁵ Comparative Pathology Shared Resource, University of Minnesota, College of Veterinary Medicine, St. Paul, Minnesota 55108, United States. ⁶ Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota 55455, United States.）

出处： ACS applied bio materials 2025

关键词： UV-initiated cross-linking;biodegradability;biopolymer;drug delivery;hydrogel microspheres;transarterial embolization.

摘要： Transarterial embolization (TAE) is an image-guided, minimally invasive procedure for treating various clinical conditions by delivering embolic agent ...

作者： Qianmin Ge ^{#  1}, Jinyan Lin ^{#  2}, YeYe Zhang  ², Hong Wei  ¹, Min Kang  ¹, Jie Zou  ¹, Qian Ling  ¹, Hui Huang  ¹, Sanhua Xu  ¹, Xu Chen  ¹, Yi Shao  ³ （Affiliations ¹ Department of Ophthalmology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. ² School of Science and Center for Theoretical Physics, Hainan University, Haikou, Hainan, 570288, China. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Eye Disease, Shanghai, 200080, China. freebee99@163.com.）

出处： Journal of imaging informatics in medicine 2025

关键词： Classification;Deep convolutional neural network;Diagnosis;In vivo confocal microscope;Meibomian gland dysfunction.

摘要： The objectives of this study are to construct a deep convolutional neural network (DCNN) model to diagnose and classify meibomian gland dysfunction (M ...

作者： Yan Zhu  ^{1   2   3}, Xin Yu  ², Mingxuan Hao  ¹, Yushan Wang  ², Gentao Fan  ², Hongbo Qian  ², Peng Jiang  ², Zhengdong Cai  ³, Zhiwei He  ², Guangxin Zhou  ^{1   2   3   4   5} （Affiliations ¹ Department of Orthopaedics, Jinling Hospital, Affiliated Hospital of Medical School, Southeast University, 210000 Nanjing, China. ² Department of Orthopaedics, Jinling Hospital, Medical School of Nanjing University, Nanjing 210000, China. ³ Department of Orthopaedics, Shanghai General Hospital, Nanjing Medical University, Shanghai 200000, China. ⁴ Wuxi Xishan NJU Institute of Applied Biotechnology, Wuxi 214000, China. ⁵ State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210000, China.）

出处： ACS applied bio materials 2025

关键词： BMP-2 peptide;Bone defects;Controlled release;Osteogenesis;α-TCP/SF microspheres.

摘要： The repair and reconstruction of bone defects remain a challenge in orthopedics. Inadequate mechanical qualities, poor biocompatibility, and insuffici ...

作者： Qian Zhu  ¹, Xiaoxin Liu  ², Yuan Qu  ³, Yan Jiang  ⁴, Xinyi Liu  ⁵, Yu Xiao  ⁶, Kangjia Lv  ⁷, Yupeng Xu  ⁸, Kun Liu  ⁹ （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: qelight@sjtu.edu.cn. ² Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: liuxiaoxin99@126.com. ³ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: yyqy32@126.com. ⁴ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: jy_470639444@163.com. ⁵ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: liuxinyi@sjtu.edu.cn. ⁶ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: whitexy@foxmail.com. ⁷ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: 18315319525@163.com. ⁸ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: kevinxu@sjtu.edu.cn. ⁹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China; Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. Electronic address: drliukun@sjtu.edu.cn.）

出处： The journal of nutrition, health & aging 2025

关键词： Diet;Neurodegeneration;Optical coherence tomography;Retina;The UK Biobank.

摘要： Background: Retinal sublayer thickness is associated with both ophthalmic and neurodegenerative diseases, serving as a valuable biomarker. Despite the ...

作者： Haoran Mu  ¹, Qi Zhang  ², Dongqing Zuo  ¹, Jinzeng Wang  ³, Yining Tao  ¹, Zhen Li  ⁴, Xin He  ¹, Huanliang Meng  ¹, Hongsheng Wang  ¹, Jiakang Shen  ¹, Mengxiong Sun  ¹, Yafei Jiang  ¹, Weisong Zhao  ¹, Jing Han  ¹, Mengkai Yang  ¹, Zhuoying Wang  ¹, Yu Lv  ¹, Yuqin Yang  ⁵, Jing Xu  ¹, Tao Zhang  ¹, Liu Yang  ¹, Jun Lin  ⁶, Feng Tang  ⁷, Renhong Tang  ⁸, Haiyan Hu  ⁹, Zhengdong Cai  ¹, Wei Sun  ¹⁰, Yingqi Hua  ¹¹ （Affiliations ¹ Department of Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. ² Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ³ National Research Center for Translational Medicine at Shanghai, State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: jz.wang@sjtu.edu.cn. ⁴ State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, China; Simcere Zaiming Pharmaceutical Co., Ltd., Shanghai, China. ⁵ Department of Laboratory Animal Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁶ Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ⁷ State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, China; Jiangsu Simcere Pharmaceutical Co., Ltd., Nanjing, China. ⁸ State Key Laboratory of Neurology and Oncology Drug Development, Nanjing, China; Jiangsu Simcere Pharmaceutical Co., Ltd., Nanjing, China; Simcere Zaiming Pharmaceutical Co., Ltd., Shanghai, China. ⁹ The Drug and Device Phase I Clinical Research Ward/Demonstration Research Ward of Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ¹⁰ Department of Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. Electronic address: viv-sun@sjtu.edu.cn. ¹¹ Department of Orthopedic Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China. Electronic address: hua_yingqi@163.com.）

出处： Cell reports. Medicine 2025

关键词： IKZF1;MAT2A;MTAP deletion;PD-L1;immunotherapy;methionine metabolism;osteosarcoma;tumor microenvironment.

摘要： Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomic ...

作者： Yun Xie¹;Hui Lv¹;Daonan Chen¹;Peijie Huang¹;Zhigang Zhou¹;Ruilan Wang² （¹Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, Shanghai 201600, PR China;²Corresponding author at: Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 650 New Songjiang Road, Songjiang, Shanghai 201600, PR China.;Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Songjiang, Shanghai 201600, PR China）

出处： International Journal of Cardiology: Heart & Vasculature 2025

关键词： Sepsis;Acute myocardial injury;CD36

摘要： Background: Sepsis-induced myocardial injury (SIMI) is a prevalent form of organ dysfunction with a significant impact on the mortality rate among sep ...

作者： Wenzhe Qian  ^{1   2}, Yue Wu  ^{1   2}, Xin Liu  ^{1   2}, Yuying Liu  ³, Min Li  ³, Ting Zhao  ³, Na Chen ^{#  4}, Bilian Ke ^{#  5   6} （Affiliations ¹ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China. ² National Clinical Research Center for Eye Diseases, Shanghai, China. ³ Department of Ophthalmology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai, 200127, China. ⁴ Department of Ophthalmology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai, 200127, China. chenna9972@163.com. ⁵ Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai, 200080, China. kebilian@126.com. ⁶ Department of Ophthalmology, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 160 Pujian Road, Shanghai, 200127, China. kebilian@126.com.）

出处： Journal of ophthalmic inflammation and infection 2025

关键词： Conjunctival epithelium;Cyclosporine A;Goblet cell;Interferon-γ;Mucin 5AC;Refractive surgery;Tear film;Tumor Necrosis Factor-α.

摘要： Background: Corneal refractive surgeries offer rapid vision correction, while dry eye disease remains a common postoperative complication that signifi ...

作者： D X Chen  ¹, Y J Wang  ¹, J Chen  ¹, J J Wang  ¹, B Zhang  ¹, H D Zou  ¹, X Xu  ¹, X G He  ¹ （Affiliation ¹ Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Tongji University, Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Center of Eye Shanghai Key Laboratory of ocular fundus diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai University of Traditional Chinese Medicine, School of Public Health, Shanghai 201103, China.）

出处： [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 2025

摘要： Objective: To investigate age-related dynamics of refractive compensation for axial elongation in children aged 6-9 years, and examine the modulating ...

作者： Binle Tian ^{#  1   2}, Zhilong Wang ^{#  3}, Mei Cao ^{#  4}, Na Wang ^{#  5}, Xuebing Jia  ^{1   2}, Yuanyuan Zhang  ³, Jingyi Zhou  ¹, Sijia Liu  ⁶, Wen Zhang  ³, Xiao Dong  ¹, Zheng Li  ⁷, Junli Xue  ⁸, JianFei Wang  ^{9   10}, Guo-Huang Fan  ¹¹, Qi Li  ^{12   13} （Affiliations ¹ Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ² Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. ³ Department of Oncology, Immunophage Biotech Co., Ltd., 10 Lv Zhouhuang Road, Shanghai, 201114, China. ⁴ Department of Gynecology and Obstetrics, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, China. ⁵ Department of Antibody Development, Immunophage Biotech Co., Ltd., 10 Lv Zhouhuang Road, Shanghai, 201114, China. ⁶ Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, China. ⁷ Department of Autoimmune Disease, Immunophage Biotech Co., Ltd., 10 Lv Zhouhuang Road, Shanghai, 201114, China. ⁸ Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200123, China. 1310666xuejunli@tongji.edu.cn. ⁹ Excecutive Office, Immunophage Biotech Co., Ltd., 10 Lv Zhouhuang Road, Shanghai, 201114, China. jfwang@immunophage.com.cn. ¹⁰ Shanghai Laboratory Animal Research Center, Shanghai, 201203, China. jfwang@immunophage.com.cn. ¹¹ Excecutive Office, Immunophage Biotech Co., Ltd., 10 Lv Zhouhuang Road, Shanghai, 201114, China. ghfan@immunophage.com.cn. ¹² Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. leeqi@sjtu.edu.cn. ¹³ Shanghai Key Laboratory of Pancreatic Disease, Institute of Pancreatic Disease, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. leeqi@sjtu.edu.cn.）

出处： Journal of experimental & clinical cancer research : CR 2025

关键词： CCR8;IPG0521m;Liver cancer;Single-cell sequencing;Tregs;Tumor microenvironment.

摘要： Background: Regulatory T cells (Tregs) are the main immunosuppressive cells in tumor immune microenvironment (TIME). However, systemic Treg depletion ...

作者： Shitong Zhan ^{#  1}, Feng Chen ^{#  1}, Lijuan Huang  ¹, Lin Chen  ¹, Haoyi Jia  ¹, Shaofei Ma  ², Min Tang  ³, Chongzhi Zhou  ⁴, Yanmin Chen  ⁴, Ye Yang  ¹ （Affiliations ¹ Obstetrics and Gynecology Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Hongkou, Shanghai 200080, China. ² Pathology Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Hongkou, Shanghai 200080, China. ³ Surgery Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Hongkou, Shanghai 200080, China. ⁴ Educational Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, Hongkou, Shanghai 200080, China.）

出处： Obstetrics and gynecology international 2025

关键词： BRCA;PARPi;homologous recombination(HRR);ovarian cancer;prognosis.

摘要： Backgrouds: Whether homologous recombination repair (HRR) mutation has a differential effect on the prognosis has not been confirmed by current studie ...