作者： Qingling Zhang  ¹, Xiuhua Fu  ², Changzheng Wang  ³, Huahao Shen  ⁴, Lei Zhu  ⁵, Guochao Shi  ⁶, Zhongmin Qiu  ⁷, Zhongguang Wen  ⁸, Wei Gu  ⁹, Wei Luo  ¹, Lina Zhao  ¹⁰, Yunqin Chen  ¹⁰, Sam Lim  ¹⁰, Chang Xiao  ¹⁰, Jian Kang  ¹¹, Yunhui Zhang  ¹², Mao Huang  ¹³, Jinfu Xu  ¹⁴, Kewu Huang  ¹⁵, Qiang Li  ¹⁶, Xiangyan Zhang  ¹⁷, Jianping Zhao  ¹⁸, Xiaoxia Liu  ¹⁹, Shenghua Sun  ²⁰, Huaping Tang  ²¹, Bei He  ²², Shaoxi Cai  ²³, Ping Chen  ²⁴, Chunhua Wei  ²⁵, Guangfa Wang  ²⁶, Ping Chen  ²⁷, Lixin Xie  ²⁸, Jiangtao Lin  ²⁹, Yuling Tang  ³⁰, Zhihai Han  ³¹, Kian Fan Chung  ³², Nanshan Zhong  ¹, C-BIOPRED consortium  ¹ （Affiliations 1 Department of pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. 2 Department of Respiratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China. 3 Department of Respiratory Medicine, Xinqiao Hospital, Army Military Medical University, Chongqing, China. 4 Department of Respiratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. 5 Department of Respiratory Medicine, Zhongshan Hospital, Shanghai, China. 6 Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 7 Department of Respiratory Medicine, Shanghai Tongji Hospital, Shanghai, China. 8 Department of Respiratory Medicine, The First Affiliated Hospital of PLA General Hospital, Beijing, China. 9 Department of Respiratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. 10 AstraZeneca, Shanghai, China. 11 Department of Respiratory Medicine, The First Hospital of China Medical University, Shenyang, China. 12 Department of Respiratory Medicine, The First People\'s Hospital of Yunnan Province, Kunming, China. 13 Department of Respiratory Medicine, Jiangsu Province Hospital, Nanjing, China. 14 Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Shanghai, China. 15 Department of Respiratory Medicine, Beijing Chao-Yang Hospital, Beijing, China. 16 Department of Respiratory Medicine, Shanghai General Hospital, Shanghai, China. 17 Department of Respiratory Medicine, Guizhou Province People\'s Hospital, Guiyang, China. 18 Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 19 Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, China. 20 Department of Respiratory Medicine, The Third Xiangya Hospital of Central South University, Changsha, China. 21 Department of Respiratory Medicine, Qingdao Municipal Hospital, Qingdao, China. 22 Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China. 23 Department of Respiratory Medicine, Nanfang Hospital of Southern Medical University, Guangzhou, China. 24 Department of Respiratory Medicine, The General Hospital of Shenyang Military, Shenyang, China. 25 Department of Respiratory Medicine, Weifang Asthma hospital, Weifang, China. 26 Department of Respiratory Medicine, Peking University First Hospital, Beijing, China. 27 Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, China. 28 College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China. 29 Department of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China. 30 Department of Respiratory Medicine, The First Hospital of Changsha, Changsha, China. 31 Department of Respiratory Medicine, Navy General Hospital, Beijing, China. 32 National Heart and Lung Institute, Imperial College London, & Royal Brompton & Harefield NHS Foundation Trust, London, SW3, UK.）

出处： Clinical and translational medicine 2022 Vol.12 No.2 Pe710

关键词： blood eosinophil count;cigarette smoking;exacerbations;fractional exhaled nitric oxide;severe asthma.

摘要： Dear Editor, In China, asthma affects 45.7 million adults with a prevalence of 4.2%, 1 while that of severe asthma ranges from 3.4% to 8.3% among a ...

作者： Jiangtao Lin ^{#  1}, Wenya Wang ^{#  2}, Huaping Tang  ³, Jianmin Huo  ⁴, Yuhai Gu  ⁵, Rongyu Liu  ⁶, Ping Chen  ⁷, Yadong Yuan  ⁸, Xiaohong Yang  ⁹, Jianying Xu  ¹⁰, Dejun Sun  ¹¹, Najia Li  ¹², Shujuan Jiang  ¹³, Yiqiang Chen  ¹⁴, Changzheng Wang  ¹⁵, Lan Yang  ¹⁶, Xiaoju Liu  ¹⁷, Dong Yang  ¹⁸, Wei Zhang  ¹⁹, Zhuochang Chen  ²⁰, Qichang Lin  ²¹, Chuntao Liu  ²², Jianying Zhou  ²³, Xin Zhou  ²⁴, Chengping Hu  ²⁵, Ping Jiang  ²⁶, Wei Zhou  ²⁷, Jie Zhang  ²⁸, Shaoxi Cai  ²⁹, Chen Qiu  ³⁰, Mao Huang  ³¹, Yijiang Huang  ³², Huiguo Liu  ³³, China Asthma Research Collaboration Network （Affiliations 1 Department of Pulmonary and Critical Care Medicine, National Clinical Research Center of Respiratory Disease, China-Japan Friendship Hospital, Beijing, China. jiangtao_l@263.net. 2 Department of Pulmonary and Critical Care Medicine, National Clinical Research Center of Respiratory Disease, China-Japan Friendship Hospital, Beijing, China. 3 Department of Pulmonary and Critical Care Medicine, Qingdao Municipal Hospital, Qingdao, China. 4 Department of Respiratory Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. 5 Department of Respiratory Medicine, Qinghai Provincial People\'s Hospital, Xi\'ning, China. 6 Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China. 7 Department of Respiratory Medicine, General Hospital of Northern Theater Command, Shenyang, China. 8 Department of Respiratory Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, China. 9 Department of Pulmonary and Critical Care Medicine, Xinjiang Uiger Municipal People\'s Hospital, Urumqi, China. 10 Department of Pulmonary and Critical Care Medicine, Shanxi Bethune Hospital, Shanxi, China. 11 Department of Pulmonary and Critical Care Medicine, Inner Mongolia People\'s Hospital, Hohhot, China. 12 Department of Respiratory Medicine, Daqing Oilfield General Hospital, Daqing, China. 13 Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Jinan, China. 14 Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Guangxi, China. 15 Department of Respiratory Medicine, Xinqiao Hospital of Army Medical University, Chongqing, China. 16 Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Xi\'an Jiaotong University, Xi\'an, China. 17 Department of Geriatric Respiration, The First Hospital of Lanzhou University, Lanzhou, China. 18 Department of Respiration, Zhongshan Hospital Fudan University, Shanghai, China. 19 Department of Respiratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, China. 20 Department of Respiratory Medicine, Henan Provincial People\'s Hospital, Zhengzhou, China. 21 Department of Respiratory Medicine, The First Affiliated Hospital of Fujian Medical University, Xiamen, China. 22 Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, China. 23 Department of Respiratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, The First Hospital of Zhejiang Province, Hangzhou, China. 24 Department of Respiratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. 25 Department of Pulmonary and Critical Care Medicine, Xiangya Hospital Central South University, Changsha, China. 26 Department of Respiratory Medicine, Tianjin First Central Hospital, Tianjin, China. 27 Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical University, Ningxia, China. 28 Department of Pulmonary and Critical Care Medicine, The Second Hospital of Jilin University, Changchun, China. 29 Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern University of Science and Technology, Guangzhou, China. 30 Department of Pulmonary and Critical Care Medicine, Shenzhen People\'s Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, China. 31 Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 32 Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan, China. 33 Department of Respiratory Medicine, Tongji Hospital, Tongji Medical college Huazhong University of Science and Technology, Wuhan, China.）

出处： Allergy, asthma & immunology research 2022 Vol.14 No.1 P85-98

关键词： Asthma;internet-based intervention;outpatient monitoring;patient adherence.

摘要： Purpose: As stated in the Global Initiative for Asthma, there are still some asthmatic patients who have not achieved asthma control. Mobile is a usef ...

作者： Wei Zhang  ¹, Jinfeng Wang  ¹, Runze Linghu  ², Xiaoyan Chen  ³, Changfeng Dong  ⁴, Shumei Zhang  ⁵, Hao Han  ⁶, Xinping Ren  ⁷, Xiaopan Zou  ⁸, Jiaojiao Ding  ⁹, Suya Ma  ¹⁰, Xueping Yang  ¹¹, Chunlin Tang  ¹², Qiyu Zhao  ¹³, Yaning Yao  ¹⁴, Yuying Cai  ¹⁵, Linsong Wu  ¹⁶, Long Liu  ¹⁷, Jing Dong  ¹⁸, Ruiqing Du  ¹⁹, Wanying Jia  ²⁰, Yongyan Gao  ²¹, Ruifang Zhang  ²², Hongyu Zhou  ²³, Han Yu  ²⁴, Zuyi Mao  ²⁵, Rongqin Zheng  ²⁶, Ping Liang  ²⁷ （Affiliations 1 Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, China. 2 Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. 3 Department of Ultrasound, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, China. 4 Department of Medical Ultrasonics, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People\'s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China. 5 Department of Ultrasound, Guangzhou Eighth People\'s Hospital, Guangzhou Medical University, Guangzhou, China. 6 Department of Ultrasound, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China. 7 Department of Ultrasound, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. 8 Department of Ultrasound, Mianyang Center Hospital, Mianyang, China. 9 Department of Abdominal Ultrasound, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China. 10 Department of Ultrasound, Ningbo Yinzhou No. 2 Hospital, Ningbo, China. 11 Department of Ultrasound, Beijing Ditan Hospital, Capital Medical University, Beijing, China. 12 Department of Ultrasound, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China. 13 Department of Ultrasound, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. 14 Department of Ultrasound, The First Hospital of Lanzhou University, Lanzhou, China. 15 Ultrasound Imaging Department, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China. 16 Department of Ultrasound, Fuyang People\'s Hospital, Fuyang, China. 17 Department of Medical Ultrasonography, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 18 Department of Ultrasound, Harbin Medical University Cancer Hospital, Harbin, China. 19 Ultrasonography, Shijiazhuang Fifth Hospital, Shijiazhuang, China. 20 Department of Ultrasound, The Second Affiliated Hospital of Xi\'an Jiaotong University, Xi\'an, China. 21 Ultrasound Department, Third Medical Center of PLA General Hospital, Beijing, China. 22 Department of Ultrasound, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 23 Department of Ultrasound, The Third Central Hospital of Tianjin, Tianjin, China. 24 Department of Ultrasound, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 25 Department of Ultrasound, Yichang Central People\'s Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China. 26 Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, China. zhengrq@mail.sysu.edu.cn. 27 Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China. liangping301@126.com.）

出处： European radiology 2022

关键词： Alanine transaminase;Elasticity imaging techniques;Liver cirrhosis;Spleen;Ultrasonography.

摘要： Objectives: To compare the performance of spleen stiffness measurement (SSM) and liver stiffness measurement (LSM) by sound touch elastography (STE) f ...

作者： Peirong Huang  ^{1   2   3}, Siddharth Narendran  ^{1   2   4}, Felipe Pereira  ^{1   2   5}, Shinichi Fukuda  ^{1   2   6}, Yosuke Nagasaka  ^{1   2}, Ivana Apicella  ^{1   2}, Praveen Yerramothu  ^{1   2}, Kenneth M Marion  ⁷, Xiaoyu Cai  ^{1   2}, Srinivas R Sadda  ^{7   8}, Bradley D Gelfand  ^{1   2   9}, Jayakrishna Ambati  ^{1   2   10   11} （Affiliations 1 Center for Advanced Vision Science, University of Virginia School of Medicine, Charlottesville, VA, USA. 2 Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville, VA, USA. 3 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Aravind Eye Care System, Madurai, India. 5 Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. 6 Department of Ophthalmology, University of Tsukuba, Tsukuba, Ibaraki, Japan. 7 Doheny Eye Institute, Los Angeles, CA, USA. 8 Department of Ophthalmology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA. 9 Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville, VA, USA. 10 Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA. 11 Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.）

出处： Translational vision science & technology 2022 Vol.11 No.3 P13

摘要： Purpose: Subretinal injection (SRI) in mice is widely used in retinal research, yet the learning curve (LC) of this surgically challenging technique i ...

作者： Minwei He  ¹, Xing Wang  ², Wei Chen  ¹, Jianzhi Zhang  ³, Ying Xiong  ³, Lulu Cao  ¹, Liyi Zhang  ³, Ning Zhao  ¹, Yue Yang  ⁴, Lu Wang  ⁵ （Affiliations 1 Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Medical Immunology of the Ministry of Public Health, Beijing, China. 2 Department of Thoracic Surgery II, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, China; Department of Thoracic Surgery, Shanghai General Hospital, Shanghai, China. 3 Department of Thoracic Surgery II, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, China. 4 Department of Thoracic Surgery II, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, China. Electronic address: zlyangyue@bjmu.edu.cn. 5 Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Key Laboratory of Medical Immunology of the Ministry of Public Health, Beijing, China. Electronic address: wanglu@bjmu.edu.cn.）

出处： Life sciences 2022 P120293

关键词： EGFR;NSCLC;PTEN;PTPIP51.

摘要： Protein tyrosine phosphatase interacting protein 51 (PTPIP51) interacts with two non-receptor tyrosine phosphatases and induces apoptosis. In the pres ...

作者： Ke Sun  ¹, Meiling Li  ², Mingdong Shang  ³, Xiaolian Su  ⁴, Jiabi Zhao  ³, Bin Wang  ², Chunyan Wu  ⁵, Lei Zhang  ², Shan Yang  ⁶, Xiwen Sun  ⁷ （Affiliations 1 Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China; Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, China. 2 Department of Radiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 3 Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, China. 4 Department of Radiology, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, China. 5 Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, China. 6 Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: syys77@126.com. 7 Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, China. Electronic address: sunxiwen5256@163.com.）

出处： Lung cancer (Amsterdam, Netherlands) 2022 Vol.166 P63-69

关键词： Computed tomography;Gene;Non-small cell lung cancer;Prognosis;Pure-solid manifestation.

摘要： Purpose: To investigate whether genetic status is associated with the prognosis of patients with clinical stage (c-stage) I non-small cell lung cancer ...

作者： Mengya Zhao  ¹, Ping Ma  ², Qinghong Xie  ³, Anh Bui  ³, Sean Yonamine  ³, Armin Hinterwirth  ⁴, Lina Zhong  ⁴, Cindi Chen  ⁴, Thuy Doan  ⁵, Ying Han  ⁶ （Affiliations 1 Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, 94143, USA; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200940, China. 2 Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, 94143, USA; Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China. 3 Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, 94143, USA. 4 F. I. Proctor Foundation, University of California, San Francisco, San Francisco, CA, 94143, USA. 5 Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, 94143, USA; F. I. Proctor Foundation, University of California, San Francisco, San Francisco, CA, 94143, USA. 6 Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, 94143, USA; Ophthalmology Section, Surgical Service, San Francisco Veterans Affairs Medical Center, San Francisco, CA, 94121, USA. Electronic address: ying.han@ucsf.edu.）

出处： Experimental eye research 2022 P109025

关键词： Aqueous humor;Biomarkers;POAG;RNA sequencing.

摘要： Glaucoma is a heterogeneous group of progressive optic neurodegenerative. Although most patients with primary open angle glaucoma (POAG) are stable fo ...

作者： Xiao-Dong Mo  ^{1   2}, Shen-Da Hong  ³, Yan-Li Zhao  ⁴, Er-Lie Jiang  ⁵, Jing Chen  ⁶, Yang Xu  ⁷, Zi-Min Sun  ⁸, Wei-Jie Zhang  ⁹, Qi-Fa Liu  ¹⁰, Dai-Hong Liu  ¹¹, Ding-Ming Wan  ¹², Wen-Jian Mo  ¹³, Han-Yun Ren  ¹⁴, Ting Yang  ¹⁵, He Huang  ¹⁶, Xi Zhang  ¹⁷, Xiao-Ning Wang  ¹⁸, Xian-Min Song  ¹⁹, Su-Jun Gao  ²⁰, Xin Wang  ²¹, Yi Chen  ²², Bing Xu  ²³, Ming Jiang  ²⁴, Xiao-Bing Huang  ²⁵, Xin Li  ²⁶, Hong-Yu Zhang  ²⁷, Hong-Tao Wang  ²⁸, Zhao Wang  ²⁹, Ting Niu  ³⁰, Ji-Shi Wang  ³¹, Ling-Hui Xia  ³², Xiao-Dan Liu  ³³, Fei Li  ³⁴, Fang Zhou  ³⁵, Tao Lang  ³⁶, Jiong Hu  ³⁷, Sui-Jing Wu  ³⁸, Xiao-Jun Huang  ^{1   2   39   40} （Affiliations 1 Peking University People\'s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China. 2 Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies, Chinese Academy of Medical Sciences (2019RU029), Beijing, China. 3 National Institute of Health Data Science at Peking University, Peking University Health Science Center, Beijing, China. 4 Hebei Yanda Lu Daopei Hospital, Beijing Lu Daopei Institute of Hematology, Beijing, China. 5 State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China. 6 Department of Hematology and Oncology, Shanghai Children\'s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 7 National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China. 8 Department of Hematology, the First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. 9 Department of Hematology, Aerospace Center Hospital, Beijing, China. 10 Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China. 11 Department of Hematology, Chinese PLA General Hospital, Beijing, China. 12 Department of Hematology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 13 Department of Hematology, Guangzhou First People\'s Hospital, School of Medicine, South China University of Technology, Guangzhou, China. 14 Department of Hematology, Peking University First Hospital, Beijing, China. 15 Fujian Medical University Union Hospital, Fujian Institute of Hematology, Department of Hematology, Fujian Provincial Key Laboratory of Hematology, Fuzhou, China. 16 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 17 Medical Center of Hematology, Xinqiao Hospital, Army Medical University; State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing, China. 18 Department of Hematology, the First Affiliated Hospital of Xi\'an Jiaotong University, Xi\'an, China. 19 Department of Hematology, Shanghai general Hospital affiliated to Shanghai Jiaotong University, Shanghai, China. 20 Department of Hematology, the First Hospital of Jilin University, Changchun, China. 21 Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. 22 Department of Hematology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou Key Laboratory of Hematology, Wenzhou, China. 23 The First Affiliated Hospital of Xiamen University, Xiamen University Institute of Hematology, Xiamen, China. 24 Hematologic Disease Center, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Research Institute of Hematology Xinjiang Medical University, Urumqi, China. 25 Department of Hematology, Sichuan Provincial People\'s Hospital, Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, China. 26 Department of Hematology, the Third Xiangya Hospital, Central South University, Changsha, China. 27 Department of Hematology, Peking University Shenzhen Hospital, Shenzhen, China. 28 Department of Hematology, Shengjing Hospital of China Medical University, Shenyang, China. 29 Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. 30 Department of Hematology, West China hospital, Sichuan University, Chengdu, China. 31 Guizhou Province Hematopoietic Stem Cell Transplantation Center, Department of Hematology, Key Laboratory of Hematological Disease Diagnostic and Treat Centre of Guizhou Province, The Affiliated Hospital of Guizhou Medical University, Guiyang, China. 32 Division of Bone Marrow Transplantation, Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 33 Department of Hematology, the Affiliated Hospital of Qingdao University, Qingdao, China. 34 Department of Hematology, the First Affiliated Hospital of Nanchang University, Nanchang, China. 35 Department of Hematology, the 960 Hospital of the PLA Joint Logistics Support Force, Jinan, China. 36 Department of Hematology, People\'s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China. 37 Blood and Marrow Transplantation Center, Department of Hematology, Shanghai Institute of Hematology, Collaborative Innovation Center of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. 38 Department of Hematology, Guangdong Provincial People\'s Hospital, Guangdong Academy of Medical Sciences, School of Medicine, South China University of Technology, Guangzhou, China. 39 Peking-Tsinghua Center for Life Sciences, Beijing, China. 40 Collaborative Innovation Center of Hematology, Peking University, Beijing, China.）

出处： American journal of hematology 2022

摘要： Steroid-refractory (SR) acute graft-versus-host disease (aGVHD) is one of the leading causes of early mortality after allogeneic hematopoietic stem ce ...

作者： Yi-Bang Cheng  ¹, Lutgarde Thijs  ², Lucas S Aparicio  ³, Qi-Fang Huang  ¹, Fang-Fei Wei  ^{2   4}, Yu-Ling Yu  ^{2   5}, Jessica Barochiner  ³, Chang-Sheng Sheng  ¹, Wen-Yi Yang  ^{2   6}, Teemu J Niiranen  ^{7   8}, José Boggia  ⁹, Zhen-Yu Zhang  ², Katarzyna Stolarz-Skrzypek  ¹⁰, Natasza Gilis-Malinowska  ¹¹, Valérie Tikhonoff  ¹², Wiktoria Wojciechowska  ¹⁰, Edoardo Casiglia  ¹², Krzysztof Narkiewicz  ¹¹, Jan Filipovský  ¹³, Kalina Kawecka-Jaszcz  ¹⁰, Ji-Guang Wang  ¹, Yan Li  ¹, Jan A Staessen  ^{14   15}, International Database of Central Arterial Properties for Risk Stratification (IDCARS) Investigators† （Affiliations 1 Department of Cardiovascular Medicine, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, State Key Laboratory of Medical Genomics, National Research Centre for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (Y.-B.C., Q.-F.H., C.-S.S., J.-G.W., Y.L.). 2 Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Belgium (L.T., F.-F.W., Y.-L.Y., W.-Y.Y., Z.-Y.Z.). 3 Servicio de Clínica Médica, Sección Hipertensión Arterial, Hospital Italiano de Buenos Aires, Argentina (L.S.A., J.Ba.). 4 Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China (F.-F.W.). 5 Research Unit Environment and Health, KU Leuven Department of Public Health and Primary Care, University of Leuven, Belgium (Y.-L.Y). 6 Department of Cardiology, Shanghai General Hospital, Shanghai, China (W.-Y.Y.). 7 Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Turku, Finland (T.J.N.). 8 Department of Medicine, TurkuUniversity Hospital and University of Turku (T.J.N.). 9 Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay (J.Bo.). 10 First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland (K.S.-S., W.W., K.K.-J.). 11 Hypertension Unit, Department of Hypertension and Diabetology, Medical University of Gdańsk, Poland (N.G.-M., K.N.). 12 Department of Medicine, University of Padua, Italy (V.T., E.C.). 13 Faculty of Medicine, Charles University, Pilsen, Czech Republic (J.F.). 14 Research Institute Alliance for the Promotion of Preventive Medicine, Mechelen, Belgium (J.A.S.). 15 Biomedical Sciences Group, Faculty of Medicine, University of Leuven, Belgium (J.A.S.).）

出处： Hypertension (Dallas, Tex. : 1979) 2022

关键词： brachial blood pressure;cardiovascular risk;central blood pressure;hypertension;mortality;population science.

摘要： Background: Whether cardiovascular risk is more tightly associated with central (cSBP) than brachial (bSBP) systolic pressure remains debated, because ...

作者： （Affiliations 1 Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou 510060, China. 2 Cancer Hospital Chinese Academy of Medical Sciences, Beijing 100021, China. 3 The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, China. 4 Harbin Medical University Cancer Hospital, Harbin 150081, China. 5 Army Medical Center of PLA, Chongqing 400042, China. 6 Jiangsu Cancer Hospital, Nanjing 210009, China. 7 Henan Cancer Hospital & Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China. 8 Zhejiang Cancer Hospital, Hangzhou 310022, China. 9 Linyi Cancer Hospital, Linyi 276000, China. 10 The Northern Jiangsu People\'s Hospital, Yangzhou 225001, China. 11 Beijing Cancer Hospital, Beijing 100142, China. 12 Jiangsu Province Hospital, Nanjing 210029, China. 13 Zhongda Hospital Southeast University, Nanjing 210009, China. 14 The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China. 15 Shanghai Chest Hospital, Shanghai 200030, China. 16 Guangxi Medical University Affiliated Tumor Hospital, Nanning 530000, China. 17 Fujian Cancer Hospital, Fuzhou 350000, China. 18 Shandong Cancer Hospital, Jinan 250117, China. 19 Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China. 20 Henan Provincial People\'s Hospital, Zhengzhou 450000, China. 21 The Affiliated Cancer Hospital of Shantou University Medical College, Shantou 515000, China. 22 Affiliated Hospital of Jining Medical University, Jining 272000, China. 23 Jiangmen Central Hospital, Jiangmen 529000, China. 24 The Second Hospital of Anhui Medical University, Hefei 230000, China. 25 The Fourth Hospital of Hebei Medical University, Shijiazhuang 050000, China. 26 The First Affiliated Hospital of Xiamen University, Xiamen 361000, China. 27 Nanjing Drum Tower Hospital, Nanjing 530000, China. 28 Anyang Cancer Hospital, Anyang 455000, China. 29 Hunan Cancer Hospital, Changsha 410000, China. 30 West China Hospital of Sichuan University, Chengdu 610000, China. 31 The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, China. 32 Jinan Central Hospital, Jinan 250000, China. 33 Zhongnan Hospital of Wuhan University, Wuhan 430000, China. 34 Henan Cancer Hospital & Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450000, China. 35 Sichuan Cancer Hospital, Chengdu 610000, China. 36 Xijing Hospital, Xi\'an 710000, China. 37 Shanghai General Hospital, Shanghai 200000, China. 38 Nantong Tumor Hospital, Nantong 226000, China. 39 Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430000, China. 40 Yichang Central People\'s Hospital, Yichang 443000, China. 41 The First Hospital of China Medical University, Shenyang 110000, China. 42 The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, China. 43 Liuzhou People\'s Hospital, Liuzhou 545000, China. 44 China-Japan Friendship Hospital, Beijing 100000, China. 45 The First Bethune Hospital of Jilin University, Changchun 130000, China. 46 Nanfang Hospital Southern Medical University, Guangzhou 510000, China. 47 Liaoning Cancer Hospital & Institute, Shenyang 110000, China. 48 The Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China. 49 The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, China. 50 The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China. 51 Xinxiang First People\'s Hospital, Xinxiang 453000, China. 52 The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310000, China. 53 The Second Affiliated Hospital of Shantou University Medical College, Shantou 515000, China. 54 Shijiazhuang People\'s Hospital, Shijiazhuang 050000, China. 55 Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China. 56 The Second People\'s Hospital of Yibin, Yibin 644000, China. 57 Chinese PLA General Hospital, Beijing 100000, China. 58 The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510000, China. 59 The First Affiliated Hospital of Nanchang University, Nanchang 330000, China. 60 The Second Affiliated Hospital of Army Medical University, Chongqing 400037, China. 61 Xuzhou Central Hospital, Xuzhou 221000, China. 62 Jiangxi Cancer Hospital, Nanchang 330000, China. 63 Tongji Hospital Affiliated to Tongji Medical College, Wuhan 430000, China. 64 Shanxi Bethune Hospital, Taiyuan 030000, China. 65 The 900th Hospital of the Joint Logistic Support Force of the Chinese People\'s Liberation Army, Fuzhou 350000, China. 66 Anhui Provincial Cancer Hospital, Hefei 230000, China. 67 Qingdao Central Hospital, Qingdao 266000, China. 68 HanDan Central Hospital, Handan 056000, China. 69 Tianjin Medical University Cancer Institute & Hospital, Tianjin 300000, China. 70 The Second Hospital of Jilin University, Changchun 130000, China. 71 Shandong Provincial Hospital, Jinan 250000, China. 72 HuBei Cancer Hospital, Wuhan 430000, China. 73 Shanghai Junshi Biosciences, Shanghai 200126, China. 74 Shanghai Junshi Biosciences, Shanghai 200126, China; TopAlliance Biosciences, Rockville, MD 20850, USA. 75 TopAlliance Biosciences, Rockville, MD 20850, USA. 76 Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou 510060, China. Electronic address: xurh@sysucc.org.cn. 77 Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China; Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou 510060, China. Electronic address: wangfeng@sysucc.org.cn.）

出处： Cancer cell 2022

关键词： PD-1 inhibitor;advanced esophageal squamous cell carcinoma;double-blind;immunotherapy;multi-center;paclitaxel plus cisplatin;randomized study.

摘要： Platinum-based chemotherapy is the standard first-line treatment for advanced esophageal squamous cell carcinoma (ESCC). In this phase 3 study (Clinic ...