作者： Jingwen Zhou  ¹, Huanqiang Zhao  ^{2   3}, Han Yang  ¹, Chunyan He  ¹, Wen Shu  ¹, Zelin Cui  ¹, Qingzhong Liu  ⁴ （Affiliations 1 Department of Clinical Laboratory, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 2 Obstetrics and Gynaecology Hospital, Fudan University, Shanghai, China. 3 The Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China. 4 Department of Clinical Laboratory, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.）

出处： Frontiers in cellular and infection microbiology 2022 Vol.12 P746746

关键词： SprC;Staphylococcus aureus;metabolomics;regulation role;small RNA;transcriptome.

摘要： Aim: Our previous proteomic analysis showed that small RNA SprC (one of the small pathogenicity island RNAs) of Staphylococcus aureus possesses the ab ...

作者： Zhencang Zhou  ^{1   2}, Pengqiang Wu  ¹, Fujue Wang  ¹, Huan Tao  ¹, Yingying Chen  ¹, Jie Gao  ^{1   3}, Dengke Chen  ², Yongqian Jia  ¹ （Affiliations 1 Department of Hematology and Research Laboratory of Hematology, West China Hospital of Sichuan University, Chengdu, Sichuan, China. 2 Department of Hematology, The Third Affiliated Hospital of Zunyi Medical University (The First People\'s Hospital of Zunyi ), Zunyi, Guizhou, China. 3 Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.）

出处： Medicine 2022 Vol.101 No.9 Pe28938

摘要： Rationale: Marginal zone B cell lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) has an indolent natural course and disseminates slow ...

作者： Mengdi Xia¹;Fen Zhao²;Yongji Zhang²;Zhihuang Zheng³;Yun Zhou²CA1;Tong Liu²CA2 （1 Nanchong Key Laboratory of Basic Science & Clinical Research On Chronic Kidney Disease, Department of Nephrology, The Second Clinical Medical Institution of North Sichuan Medical College (Nanchong Central Hospital), Nanchong, China; 2 Shanxi Kidney Disease Institute, Department of Nephrology, Shanxi Provincial People’s Hospital, The Affiliated People’s Hospital of Shanxi Medical University, Taiyuan, China; 3 Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China）

出处： European Journal of Medical Research 2022 Vol.27 No.1

关键词： Antineutrophil cytoplasmic antibody-associated vasculitis (AAV);ANCA-associated glomerulonephritis;Hub gene;CIBERSORT;Immune infiltration

摘要： Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of life-threatening systemic autoimmune diseases. The aim of th ...

作者： Ying Peng  ^{1   2}, Peihong Xu  ³, Juan Shi  ^{1   2}, Yifei Zhang  ^{1   2}, Shujie Wang  ^{1   2}, Qidong Zheng  ⁴, Yufan Wang  ⁵, Tingyu Ke  ⁶, Li Li  ⁷, Dong Zhao  ⁸, Yuancheng Dai  ⁹, Qijuan Dong  ¹⁰, Bangqun Ji  ¹¹, Fengmei Xu  ¹², Weiqiong Gu  ^{1   2}, Weiqing Wang  ^{1   2} （Affiliations 1 Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Pharmacy, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Internal Medicine, The Second People\'s Hospital of Yuhuan, Yuhuan, China. 5 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Department of Endocrinology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China. 7 Department of Endocrinology, Ningbo First Hospital, Ningbo, China. 8 Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China. 9 Department of Internal Medicine of Traditional Chinese Medicine, Sheyang Diabetes Hospital, Yancheng, China. 10 Department of Endocrinology and Metabolism, People\'s Hospital of Zhengzhou Affiliated Henan University of Chinese Medicine, Zhengzhou, China. 11 Department of Endocrinology, Xingyi People\'s Hospital, Xinyi, China. 12 Department of Endocrinology and Metabolism, Hebi Coal (Group), Ltd, General Hospital, Hebi, China.）

出处： Journal of diabetes 2022

关键词： basal insulin;body mass index;glycemic hemoglobin;premixed insulin;type 2 diabetes.

摘要： Background: To investigate the different efficacies of glycemic control between basal and premixed insulin in participants with type 2 diabetes (T2DM) ...

作者： Shuyuan Zhang ^{#  1}, Yixuan Zhong ^{#  1}, Lixin Wang ^{#  2}, Xinhua Yin ^{#  3   4}, Yufeng Li  ⁵, Yunlan Liu  ⁶, Qiuyan Dai  ⁷, Anli Tong  ⁸, Dongfeng Li  ⁹, Liangqing Zhang  ¹⁰, Ping Li  ¹¹, Guohui Zhang  ¹², Rongjie Huang  ¹³, Jinguang Liu  ¹⁴, Luosha Zhao  ¹⁵, Jing Yu  ¹⁶, Xinjun Zhang  ¹⁷, Li Yang  ¹⁸, Jun Cai  ¹⁹, Weili Zhang  ²⁰, STEP Study Group （Affiliations 1 State Key Laboratory of Cardiovascular Disease, Hypertension Center, FuWai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beilishi Road 167, Xicheng District, Beijing, 100037, China. 2 The First Affiliated Hospital of Hebei North University, Hebei, 075061, China. 3 Southern University of Science and Technology Hospital, Shenzhen, 518000, China. 4 First Affiliated Hospital of Harbin Medical University, Heilongjiang, 150081, China. 5 Beijing Pinggu Hospital, Beijing, 101200, China. 6 The First Hospital of Kunming, Yunnan, 650011, China. 7 Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. 8 Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. 9 Wuxiang County People\'s Hospital, Shanxi, 046300, China. 10 Shanxi Cardiovascular Hospital, Shanxi, 030000, China. 11 2nd Affiliated Hospital of Nan Chang University, Jiangxi, 330006, China. 12 Zhenjiang First People\'s Hospital, Jiangsu, 212002, China. 13 The First Affiliated Hospital of Guangxi Medical University, Guangxi, 530021, China. 14 Huizhou Municipal Central Hospital, Guangdong, 516001, China. 15 First Affiliated Hospital of Zhengzhou University, Henan, 450000, China. 16 Lanzhou University Second Hospital, Gansu, 730030, China. 17 West China Hospital, Sichuan University, Sichuan, 610041, China. 18 Yan\'an Hospital affiliated Kunming Medical University, Yunnan, 650101, China. 19 State Key Laboratory of Cardiovascular Disease, Hypertension Center, FuWai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beilishi Road 167, Xicheng District, Beijing, 100037, China. caijun@fuwaihospital.org. 20 State Key Laboratory of Cardiovascular Disease, Hypertension Center, FuWai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beilishi Road 167, Xicheng District, Beijing, 100037, China. zhangweili1747@yahoo.com.）

出处： Hypertension research : official journal of the Japanese Society of Hypertension 2022 P1-10

关键词： Anxiety;Cardiovascular disease;Coronavirus disease 2019 (COVID-19);Home blood pressure;Smartphone-based application.

摘要： The global coronavirus disease 2019 (COVID-19) pandemic has led to a health crisis. It remains unclear how anxiety affects blood pressure (BP) and car ...

作者： Kai Zhu ^{#  1   2   3}, Song Guo ^{#  4}, Guoyi Han  ², Xiancheng Qiang  ⁵, Mengmeng Ma  ³, Qinglei Xu  ², Wenjie Tang  ⁶, Jun Tan  ⁷ （Affiliations 1 Department of Orthopaedics, Shanghai East Hospital, Tongji University School of Medicine, No.150 Jimo Road, Shanghai, 200120, People\'s Republic of China. 2 Department of Orthopaedics II, Qingdao No.8 People\'s Hospital, No.84 Fengshan Road, Qingdao, 266121, People\'s Republic of China. 3 Research Center for Translational Medicine, Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, No.150 Jimo Road, Shanghai, 200120, People\'s Republic of China. 4 Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiaotong University, No.100 Haining Road, Shanghai, 200080, People\'s Republic of China. 5 Department of Anesthesiology, Qingdao No.8 People\'s Hospital, No. 84 Fengshan Road, Qingdao, 266121, People\'s Republic of China. 6 Research Center for Translational Medicine, Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, No.150 Jimo Road, Shanghai, 200120, People\'s Republic of China. 1701927@tongji.edu.cn. 7 Department of Orthopaedics, Shanghai East Hospital, Tongji University School of Medicine, No.150 Jimo Road, Shanghai, 200120, People\'s Republic of China. tanjuntj2012@163.com.）

出处： Molecular biology reports 2022

关键词： Apoptosis;GSK-3β;Intervertebral disc degeneration;Nucleus pulposus cells;Oxidative stress;SB216763.

摘要： Background: Oxidative stress in the intervertebral disc leads to nucleus pulposus (NP) degeneration by inducing cell apoptosis. However, the molecular ...

作者： Tao Wang ^{#  1   2   3}, Jiaxiang Bai ^{#  4}, Min Lu  ¹, Chenglong Huang  ³, Dechun Geng  ⁴, Gang Chen  ³, Lei Wang  ¹, Jin Qi  ⁵, Wenguo Cui  ⁶, Lianfu Deng  ⁷ （Affiliations 1 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. 2 Department of Orthopaedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 85 Wujin Road, 200080, Shanghai, P. R. China. 3 Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, Department of Orthopaedics, The second Affiliated Hospital of Jiaxing University, 1518 North Huancheng Road, 314000, Jiaxing, P. R. China. 4 Department of Orthopaedics, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu, P. R. China. 5 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. jinjin838@hotmail.com. 6 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. wgcui80@hotmail.com. 7 Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, 200025, Shanghai, P. R. China. lf_deng@126.com.）

出处： Nature communications 2022 Vol.13 No.1 P160

摘要： Immune response and new tissue formation are important aspects of tissue repair. However, only a single aspect is generally considered in previous bio ...

作者： Huijing Yin  ¹, Bo Jing  ², Dongliang Xu  ³, Wenzheng Guo  ⁴, Beibei Sun  ⁵, Jie Zhang  ⁶, Yueling Liao  ⁷, Hongyong Song  ⁸, Tong Wang  ², Shuli Liu  ⁹, Yanbin Kuang  ¹⁰, Min Hu  ², Kaimi Li  ², Siwei Zhang  ², Hongjia Zhang  ¹¹, Jianhua Xu  ¹², Xue Li  ¹³, Jing Du  ¹⁴, Yadi Wu  ¹⁵, Yingli Wu  ¹⁶, Qi Wang  ¹⁷, Feng Yao  ¹⁸, Y Eugene Chin  ¹⁹, Binhua P Zhou  ²⁰, Jiong Deng  ²¹ （Affiliations 1 Oncology, Fudan University Shanghai Cancer Center. 2 Shanghai Jiao Tong University. 3 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. 4 Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine. 5 Translation Medicine Center, Shanghai Chest Hospital, Shanghai Jiao Tong University. 6 Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University. 7 Pathophysiology, Shanghai Jiao Tong University School of Medicine. 8 Department of Pathophysiology, Key laboratory of Cell Differentiation and Apoptosis of Minister of Education, Shanghai Jiao Tong University School of Medicine. 9 Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People\'s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. 10 Department of Respiratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University. 11 Shanghai Jiao Tong University School of Medicine. 12 Kunming Medical University. 13 Binzhou Medical University. 14 Center of Cancer Research, Binzhou Medical University Hospital. 15 University of Kentucky Medical Center. 16 Shanghai Jiao Tong University School of Medicine, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital / Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Different. 17 Respiratory Medicine, Second Affiliated Hospital of Dalian Medical University. 18 Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai. 19 IBMS, Soochow University Medical College, 199 Ren\'ai Road, Suzhou, Jiangsu Province, 215123, China. 20 Molecular and Cellular Biochemistry, University of Kentucky School of Medicine. 21 Pathophysiology, Shanghai Jiao Tong University School of Medicine jiongdeng@bzmc.edu.cn.）

出处： Cancer research 2022

摘要： While initiation is established as a critical step in tumorigenesis, the identity of the cell-of-origin for lung adenocarcinoma and the mechanism cont ...

作者： Catar, Rusan^1,2;Herse-Naether, Melanie^1,2;Zhu, Nan^1,3;Wagner, Philine^1,2;Wischnewski, Oskar^1,2;Kusch, Angelika^1,2,4;Kamhieh-Milz, Julian⁵;Eisenreich, Andreas⁶;Rauch, Ursula⁶;Hegner, Björn^1,2,7;Heidecke, Harald⁸;Kill, Angela^9,10;Riemekasten, Gabriela^9,10,11;Kleinau, Gunnar¹²;Scheerer, Patrick^12,13;Dragun, Duska^1,2,4;Philippe, Aurelie^1,2,4 （1 Department of Nephrology and Medical Intensive Care, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 2 Center for Cardiovascular Research, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 3 Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China 4 Berlin Institute of Health, Charité—Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, 10117 Berlin, Germany 5 Department of Transfusion Medicine, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 6 Department of Cardiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 7 Vitanas Klinik für Geriatrie, 13435 Berlin, Germany 8 CellTrend GmbH, 14943 Luckenwalde, Germany 9 Deutsches Rheuma-Forschungszentrum (DRFZ), A. Leibniz Institute, 10117 Berlin, Germany 10 Department of Rheumatology and Clinical Immunology, CCM, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 11 Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), 23845 Borstel, Germany 12 Group Protein X-ray Crystallography and Signal Transduction, Institute of Medical Physics and Biophysics, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany 13 DZHK (Deutsches Zentrum für Herz-Kreislauf Forschung), Partner Site Berlin, 13353 Berlin, Germany）

出处： International Journal of Molecular Sciences 2022 Vol.23 No.1 P244

关键词： angiotensin;autoantibodies;coagulation;endothelin-1;renal crisis;renin–angiotensin system;systemic sclerosis

摘要： Scleroderma renal crisis (SRC) is an acute life-threatening manifestation of systemic sclerosis (SSc) caused by obliterative vasculopathy and thrombot ...

作者： Dashan Ai  ^{1   2}, Jinjun Ye  ³, Shihong Wei  ⁴, Yunhai Li  ⁵, Hui Luo  ⁶, Jianzhong Cao  ⁷, Zhengfei Zhu  ^{1   2}, Weixin Zhao  ^{1   2}, Qin Lin  ⁸, Huanjun Yang  ^{1   2}, Xiangpeng Zheng  ⁹, Jialiang Zhou  ¹⁰, Guang Huang  ¹¹, Ling Li  ^{1   2}, Jiancheng Li  ¹², Zhi Zhang  ¹³, Guoren Zhou  ¹⁴, Dayong Gu  ³, Mingyu Du  ³, Miao Mo  ¹⁵, HuiXun Jia  ¹⁶, Zhen Zhang  ^{1   2}, Kuaile Zhao  ^{1   2} （Affiliations 1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 3 Department of Radiation Oncology, Jiangsu Cancer Hospital, Jiangsu Institute Of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China. 4 Department of Radiation Oncology, Gansu Province Cancer Hospital, Lanzhou, China. 5 Department of Radiation Oncology, Fudan University Shanghai Cancer Center Minhang Branch Hospital, Shanghai, China. 6 Department of Radiation Oncology, Jiangxi Province Cancer Hospital, Nanchang, China. 7 Department of Radiation Oncology, Shanxi Province Cancer Hospital, Taiyuan, China. 8 Department of Radiation Oncology, First Affiliated Hospital of Xiamen University, Xiamen, China. 9 Department of Radiation Oncology, Huadong Hospital Affiliated to Fudan University, Shanghai, China. 10 Department of Radiation Oncology, Affiliated Hospital of Jiangnan University, Wuxi, China. 11 Department of Radiation Oncology, Hainan Province People\'s Hospital, Haikou, China. 12 Department of Radiation Oncology, Fujian Province Cancer Hospital, Fuzhou, China. 13 Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute Of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China. 14 Department of Internal Medicine, Jiangsu Cancer Hospital, Jiangsu Institute Of Cancer Research, Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China. 15 Department of Cancer Prevention & Clinical Statistics Center, Fudan University Shanghai Cancer Center, Shanghai, China. 16 Shanghai General Hospital, Shanghai, China.）

出处： JAMA network open 2022 Vol.5 No.2 Pe220120

摘要： Importance: Multiple paclitaxel-based regimens are widely used in chemoradiation therapy against esophageal cancer, including regimens combining pacli ...