作者： Minjie Zhao  ¹, Shuzhi Zhao  ^{2   3   4   5   6}, Min Tang  ^{2   3   4   5   6}, Tao Sun  ^{2   3   4   5   6   7}, Zhi Zheng  ^{2   3   4   5   6}, Mingming Ma  ^{2   3   4   5   6} （Affiliations 1 Department of Ophthalmology, Yixing People\'s Hospital, Jiangsu University, Zhenjiang, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai, China. 3 National Clinical Research Center for Eye Diseases, Shanghai, China. 4 Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. 5 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. 6 Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 7 Shanghai Eye Diseases Prevention & Treatment Center/Shanghai Eye Hospital, Shanghai, China.）

出处： Investigative ophthalmology & visual science 2022 Vol.63 No.3 P8

摘要： Purpose: To clarify the expression of biomarkers of retinal glial cell activation in the aqueous humor (AH) of patients with and without age-related c ...

作者： Liqun Lou  ^{1   2}, Shuangbo Kong  ², Yunyan Sun  ³, Zhenbo Zhang  ^{1   4}, Haibin Wang  ² （Affiliations 1 Reproductive Medicine Center, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. 2 Fujian Provincial Key Laboratory of Reproductive Health Research, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. 3 Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China. 4 Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.）

出处： Frontiers in cell and developmental biology 2022 Vol.10 P844623

关键词： coculture model;drug screening;epithelium;genetic manipulation;human endometrial organoids.

摘要： Since traditional two-dimensional (2D) cell culture cannot meet the demand of simulating physiological conditions in vivo, three-dimensional (3D) cult ...

作者： Mingzi Li  ¹, Mingxun Zhang  ^{2   3}, Muling Chen  ¹, Jiantao Xiao  ⁴, Xingyu Mu  ¹, Jingtao Peng  ⁵, Jie Fan  ¹ （Affiliations 1 Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, Shanghai, China. 2 Department of Pathology, the First Affiliated Hospital of Ustc, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. 3 Intelligent Pathology Institute, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China. 4 Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. 5 Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.）

出处： Cell cycle (Georgetown, Tex.) 2022 P1-15

关键词： KLF2;PIM1;circZKSCAN1;clear cell renal cell carcinoma;miR-1294.

摘要： Clear cell renal cell carcinoma (ccRCC) is one of the most common and lethal types of urologic cancer. With low survival rates among patients in advan ...

作者： Yuwan Dai  ^{1   2}, Xiangbin Kong  ³, Chencheng Yao  ⁴, Chengliang Xiong  ^{1   5}, Zheng Li  ⁴, Honggang Li  ^{1   5} （Affiliations 1 Institute of Reproductive Health/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 2 Henan Provincial People\'s Hospital, Henan, China. 3 Department of Reproductive Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 4 Department of Andrology, the Center for Men\'s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Wuhan Tongji Reproductive Hospital, Wuhan, China.）

出处： Andrology 2022

关键词： azoospermia;male factor infertility;meiosis;non-invasive;semen;sperm retrieval.

摘要： Background: Differential diagnosis of men with subtypes of non-obstructive azoospermia (NOA) is important for their treatment. Many genes are transcri ...

作者： Zhihuang Zheng  ^{1   2   3}, Dmitry Tsvetkov  ^{4   5   6}, Theda Ulrike Patricia Bartolomaeus  ^{2   7}, Cem Erdogan  ⁸, Ute Krügel  ⁹, Johanna Schleifenbaum  ⁸, Michael Schaefer  ⁹, Bernd Nürnberg  ¹⁰, Xiaoning Chai  ⁹, Friedrich-Alexander Ludwig  ¹¹, Gabriele N\'diaye  ^{2   7}, May-Britt Köhler  ^{2   7}, Kaiyin Wu  ¹², Maik Gollasch  ^{13   14   15}, Lajos Markó  ^{16   17   18   19} （Affiliations 1 Department of Nephrology/Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. 2 Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité Universitätsmedizin, Berlin, Germany. 3 Department of Nephrology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 4 Department of Nephrology/Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. dmitry.tsvetkov@charite.de. 5 Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité Universitätsmedizin, Berlin, Germany. dmitry.tsvetkov@charite.de. 6 Department of Geriatrics, University of Greifswald, University District Hospital Wolgast, Greifswald, Germany. dmitry.tsvetkov@charite.de. 7 Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. 8 Institute of Vegetative Physiology, Charité-Universitätsmedizin Berlin, Berlin, Germany. 9 Rudolf Boehm Institute for Pharmacology and Toxicology, Leipzig University, Leipzig, Germany. 10 Department of Pharmacology, Experimental Therapy and Toxicology and Interfaculty Center of Pharmacogenomics and Drug Research, University of Tübingen, Tübingen, Germany. 11 Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Leipzig, Germany. 12 Department of Pathology, Charité-Universitätsmedizin Berlin, Berlin, Germany. 13 Department of Nephrology/Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany. maik.gollasch@charite.de. 14 Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité Universitätsmedizin, Berlin, Germany. maik.gollasch@charite.de. 15 Department of Geriatrics, University of Greifswald, University District Hospital Wolgast, Greifswald, Germany. maik.gollasch@charite.de. 16 Experimental and Clinical Research Center (ECRC), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Charité Universitätsmedizin, Berlin, Germany. lajos.marko@charite.de. 17 DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany. lajos.marko@charite.de. 18 Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany. lajos.marko@charite.de. 19 Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. lajos.marko@charite.de.）

出处： Scientific reports 2022 Vol.12 No.1 P3038

摘要： Transient receptor potential channel subfamily C, member 6 (TRPC6), a non-selective cation channel that controls influx of Ca 2+ and other monovalent ...

作者： Hai-Qiang Mai ^{#  1}, Qiu-Yan Chen ^{#  1}, Dongping Chen  ², Chaosu Hu  ³, Kunyu Yang  ⁴, Jiyu Wen  ⁵, Jingao Li  ⁶, Ying-Rui Shi  ⁷, Feng Jin  ⁸, Ruilian Xu  ⁹, Jianji Pan  ¹⁰, Shenhong Qu  ¹¹, Ping Li  ¹², Chunhong Hu  ¹³, Yi-Chun Liu  ¹⁴, Yi Jiang  ¹⁵, Xia He  ¹⁶, Hung-Ming Wang  ¹⁷, Wan-Teck Lim  ¹⁸, Wangjun Liao  ¹⁹, Xiaohui He  ²⁰, Xiaozhong Chen  ²¹, Zhigang Liu  ²², Xianglin Yuan  ²³, Qi Li  ²⁴, Xiaoyan Lin  ²⁵, Shanghua Jing  ²⁶, Yanju Chen  ²⁷, Yin Lu  ²⁸, Ching-Yun Hsieh  ²⁹, Muh-Hwa Yang  ³⁰, Chia-Jui Yen  ³¹, Jens Samol  ^{32   33}, Hui Feng  ^{34   35}, Sheng Yao  ^{34   35}, Patricia Keegan  ³⁵, Rui-Hua Xu  ³⁶ （Affiliations 1 Department of Nasopharyngeal Carcinoma, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. 2 Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China. 3 Fudan University Cancer Center, Shanghai, China. 4 Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 5 Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. 6 Jiangxi Cancer Hospital, Nanchang, China. 7 Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, China. 8 Guizhou Cancer Hospital of Guizhou Medical University, Guiyang, China. 9 Shenzhen People\'s Hospital, Shenzhen, China. 10 Fujian Provincial Cancer Hospital, Fuzhou, China. 11 The People\'s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. 12 West China Hospital of Sichuan University, Chengdu, China. 13 The Second Xiangya Hospital of Central South University, Changsha, China. 14 Taichung Veterans General Hospital, Taichung, Taiwan. 15 Cancer Hospital of Shantou University Medical College, Shantou, China. 16 Jiangsu Cancer Hospital, Nanjing, China. 17 Chang Gung Memorial Hospital, Taoyuan, Taiwan. 18 National Cancer Centre, Singapore City, Singapore. 19 Nanfang Hospital, Guangzhou, China. 20 Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. 21 Zhejiang Cancer Hospital, Hangzhou, China. 22 The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China. 23 Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 24 Shanghai General Hospital, Shanghai, China. 25 Fujian Medical University Union Hospital, Fuzhou, China. 26 The Fourth Hospital of Hebei Medical University Hebei Cancer Hospital, Shijiazhuang, China. 27 Hainan General Hospital, Haikou, China. 28 Liuzhou Worker\'s Hospital, Liuzhou, China. 29 China Medical University Hospital, Taichung, Taiwan. 30 Taipei Veterans General Hospital, Taipei, Taiwan. 31 National Cheng Kung University, Tainan, Taiwan. 32 Tan Tock Seng Hospital, Singapore City, Singapore. 33 Johns Hopkins University, Baltimore, MD, USA. 34 Shanghai Junshi Biosciences, Shanghai, China. 35 TopAlliance Biosciences, Rockville, MD, USA. 36 Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China. xurh@sysucc.org.cn.）

出处： Nature medicine 2022

作者： Hang Zhang  ¹, Hong Lang  ², Mengqing Ma  ², Min Yu  ³, Hao Chai  ¹, Yuntao Hu  ¹, Wen Chen  ⁴, Xin Chen  ⁵ （Affiliations 1 Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China. 2 Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, No. 109 Longmian Road, Nanjing 211166, China. 3 Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China. 4 Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China. Electronic address: cxacf@163.com. 5 Department of Thoracic and Cardiovascular Surgery, Nanjing First Hospital, Nanjing Medical University, No. 68 Changle Road, Nanjing 210006, China. Electronic address: stevecx@njmu.edu.cn.）

出处： Clinica chimica acta; international journal of clinical chemistry 2022

关键词： Acute kidney injury;Cardiac surgery;Kidney function;Uromodulin.

摘要： Background: Acute kidney injury (AKI) is a major complication following cardiac surgery that substantially increases mortality. We explored the clinic ...

作者： Liwei An  ¹, Zhifa Cao  ², Pingping Nie  ², Hui Zhang  ³, Zhenzhu Tong  ², Fan Chen  ², Yang Tang  ¹, Yi Han  ¹, Wenjia Wang  ³, Zhangting Zhao  ³, Qingya Zhao  ⁴, Yuqin Yang  ⁴, Yuanzhi Xu  ⁵, Gemin Fang  ⁶, Lei Shi  ⁷, Huixiong Xu  ¹, Haiqing Ma  ⁸, Shi Jiao  ³, Zhaocai Zhou  ³ （Affiliations 1 Department of Medical Ultrasound, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, China. 2 CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China. 3 State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China. 4 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Stomatology, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, China. 6 Institutes of Physical Science and Information Technology, Anhui University, Hefei, China. 7 Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin, China. 8 Department of Oncology, Guangdong Academy of Medical Sciences, Guangzhou, China.）

出处： The Journal of clinical investigation 2022 Pe155468

关键词： Cell Biology;Drug therapy;Gastric cancer;Gastroenterology;Molecular biology.

摘要： The striatin-interacting phosphatase and kinase (STRIPAK) complexes integrate extracellular stimuli to result in intracellular activities. Previously, ...

作者： Chencheng Yao ^{#  1   2}, Dong Hou ^{#  3}, Zhiyong Ji  ^{1   2   4}, Dongmei Pang  ⁵, Peng Li  ¹, Ruhui Tian  ¹, Yuxiang Zhang  ¹, Ningjing Ou  ^{1   2   4}, Haowei Bai  ¹, Erlei Zhi  ¹, Yuhua Huang  ¹, Yingying Qin  ³, Jingpeng Zhao  ⁴, Chenchen Wang  ⁶, Zhi Zhou  ², Ting Guo  ³, Zheng Li  ^{1   4} （Affiliations 1 Department of Andrology, Center for Men\'s Health, Department of ART, Institute of Urology, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 School of Life Science and Technology, ShanghaiTech University, Shanghai, China. 3 Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key laboratory of Reproductive Endocrinology of Ministry of Education, and Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Jinan, China. 4 State Key Lab of Reproductive Medicine, Nanjing Medical University, Nanjing, China. 5 Jimo Hospital of Traditional Chinese Medicine Affiliated to Shandong University of Traditional Chinese Medicine, Qingdao, China. 6 Shanghai Advanced Research Institute, Stem Cell and Reproductive Biology Laboratory, Chinese Academy of Sciences, Shanghai, China.）

出处： Clinical genetics 2022

关键词： Meiosis;Gene variants;NOA;POI;SPATA22.

摘要： The genetic causes of idiopathic premature ovarian insufficiency (POI) and non-obstructive azoospermia (NOA) remain unclear. We performed whole-exome ...

作者： Wei-Jing Gong^1,2,3;Peng Cao^1,2,3;Qi-Lin Zhang^1,2;Xiao-Yu Han^4,5;Shuo-Wen Wang⁶;Yi-Fei Huang^1,2;San-Lan Wu^1,2;Qiang Li^1,2;Rui Zhang^1,2;Shuang-Bing Xu⁷;Ya-Ni Liu^1,2;Shao-Jun Shi^1,2;Yu Zhang^1,2CA1 （1 Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; 2 Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Wuhan 430022, China; 3 These authors contributed equally to this work.; 4 Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; 5 Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China; 6 Department of Clinical Pharmacy, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, No. 100 Haining Road, Shanghai 200080, China; 7 Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China）

出处： Translational Oncology 2022 Vol.19 P101393

关键词： Lung adenocarcinoma;Pemetrexed plus platinum;Metabolomics;Prediction model

摘要： Background Pemetrexed plus platinum doublet chemotherapy regimen remains to be the standard first-line treatment for lung adenocarcinoma patients. Ho ...