作者： Zili Yang  ¹, Lu-An Chen  ¹, Chuanjun Yang  ¹, Yuqian Gu  ¹, Rong Cao  ², Ke Zhong  ¹ （Affiliations 1 College of Environmental Science & Engineering, Donghua University, Shanghai, China. 2 Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.）

出处： Indoor air 2022 Vol.32 No.1 Pe12964

关键词： air quality;building microbiome;comfort;health;humidification;ultrasonic humidifier.

摘要： Portable ultrasonic humidifiers are frequently used in heating rooms to ease air dryness. However, it has also posed serious health concerns such as " ...

作者： Xiaohui Wei¹;Jielei Zhang²;Min Tang¹;Xuejiao Wang¹;Nengguang Fan¹CA1;Yongde Peng¹CA2 （1 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Road, 200080, Shanghai, China; 2 Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China）

出处： Lipids in Health and Disease 2022 Vol.21 No.1

关键词： Nonalcoholic fatty liver disease;Fat and obesity associated protein;Peroxisome proliferator-activated receptor α

摘要： Background Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The fat mass and obesity–associated protein ( ...

作者： Sun, Liya¹;Liu, Yuan¹;Liu, Xiali²;Wang, Rui¹;Gong, Jiameng¹;Saferali, Aabida³;Gao, Wei²;Ma, Aying²;Ma, Huiqiang¹;Turvey, Stuart E⁴;Fung, Shan‐Yu⁵;Yang, Hong¹ （1 School of Biomedical Engineering, The Province and Ministry Co‐Sponsored Collaborative Innovation Center for Medical Epigenetics, Intensive Care Unit of the Second Hospital, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070,, China 2 Department of Pulmonary and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 650 Xinsongjiang Road, Shanghai 201620,, China 3 Channing Division of Network Medicine, Brigham and Women\'s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston MA, 02115,, USA 4 BC Children\'s Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver BC V5Z 4H4,, Canada 5 Department of Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co‐Sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Science, Tianjin Medical University, No. 22 Qixiangtai Road, Heping District, Tianjin 300070,, China）

出处： Advanced Science 2022 Vol.9 No.3 P1-16

关键词： acute lung injury;bioactive nanoparticles;drug repurposing;inflammation;macrophages;proton pump inhibitors;Toll‐like receptors

摘要： Toll‐like receptor (TLR) activation in macrophages plays a critical role in the pathogenesis of acute lung injury (ALI). While TLR inhibition is a pro ...

作者： Limin Liao  ^{1   2   3}, Qinggang Liu  ^{1   2   3}, Huiling Cong  ^{1   2}, Zhihui Xu  ⁴, Enhui Li  ⁴, Zhiliang Weng  ⁵, Haihong Jiang  ⁵, Ben Liu  ⁶, Xiao Huang  ⁶, Shujie Xia  ⁷, Wei Wen  ⁷, Juan Wu  ^{1   2}, Guowei Shi  ⁸, Yang Wang  ⁸, Peijun Li  ⁹, Yang Yu  ⁹, Zujun Fang  ¹⁰, Jie Zheng  ¹⁰, Ye Tian  ¹¹, Donghao Shang  ¹¹, Hanzhong Li  ¹², Zhongming Huang  ¹², Liqun Zhou  ¹³, Yunxiang Xiao  ¹³, Yaoguang Zhang  ¹⁴, Jianlong Wang  ¹⁴, Xiaodong Zhang  ¹⁵, Peng Zhang  ¹⁵, Dongwen Wang  ¹⁶, Xuhui Zhang  ¹⁶, Keji Xie  ¹⁷, Bin Wang  ¹⁷, Lulin Ma  ¹⁸, Xiaojun Tian  ¹⁸, Lijun Chen  ¹⁹, Jinkai Dong  ¹⁹ （Affiliations 1 Department of Urology, China Rehabilitation Research Center, School of Rehabilitation Medicine, Capital Medical University, Beijing, China. 2 Cheeloo College of Medicine, Shandong University, Jinan, China. 3 University of Health and Rehabilitation Sciences, Qingdao, China. 4 Department of Urology, Zhejiang Provincial People\'s Hospital, Hangzhou, China. 5 Department of Urology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 6 Department of Urology, First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. 7 Department of Urology, Shanghai First People\'s Hospital, Shanghai, China. 8 Department of Urology, Shanghai Fifth People\'s Hospital, Shanghai, China. 9 Department of Urology, Ningxia Medical University General Hospital, Xining, China. 10 Department of Urology, Huashan Hospital, Fudan University, Shanghai, China. 11 Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. 12 Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China. 13 Department of Urology, Peking University First Hospital, Beijing, China. 14 Department of Urology, Beijing Hospital, Beijing, China. 15 Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. 16 Department of Urology, First Hospital of Shanxi Medical University, Taiyuan, China. 17 Department of Urology, Guangzhou First People\'s Hospital, Guangzhou, China. 18 Department of Urology, Peking University Third Hospital, Beijing, China. 19 Department of Urology, Fifth Medical Center of PLA General Hospital, Beijing, China.）

出处： Frontiers in pharmacology 2022 Vol.13 P840695

关键词： China;Hengli®;botulinum toxin type A;overactive bladder;randomized controlled trial.

摘要： Objective: To evaluate the efficacy and safety of Hengli ® Chinese botulinum toxin type A (BTX-A; 100 U) in Chinese patients with overactive bladder. ...

作者： YaQing Zhan  ¹, YiHong Ling  ^{2   3}, Qiwen Deng  ¹, YuXin Qiu  ¹, JianTong Shen  ¹, HanJin Lai  ¹, ZhaoRong Chen  ¹, ChanYan Huang  ¹, LiQun Liang  ⁴, Xiang Li  ⁵, JianFeng Wu  ⁴, WenQi Huang  ⁶, ShiHong Wen  ⁶ （Affiliations 1 Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. 2 State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China. 3 Department of Pathology, Sun Yat-sen University Cancer Center, Guangzhou, China. 4 Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; and. 5 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; huangwenqi86@aliyun.com wshih@mail.sysu.edu.cn.）

出处： Journal of immunology (Baltimore, Md. : 1950) 2022 Vol.208 No.4 P968-978

摘要： Influx of activated neutrophils into the lungs is the histopathologic hallmark of acute lung injury (ALI) after intestinal ischemia/reperfusion (I/R). ...

作者： Senlin Zhao  ^{1   2}, Yushuai Mi  ³, Binbin Zheng  ⁴, Ping Wei  ^{2   5   6}, Yanzi Gu  ⁷, Zhengxiang Zhang  ⁸, Ye Xu  ^{1   2}, Sanjun Cai  ^{1   2}, Xinxiang Li  ^{1   2}, Dawei Li  ^{1   2} （Affiliations 1 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai, China. 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 3 Department of Gastrointestinal Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. 4 Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. 5 Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China. 6 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China. 7 Department of Biobank, Fudan University Shanghai Cancer Center, Shanghai, China. 8 Department of Oncology, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.）

出处： Journal of extracellular vesicles 2022 Vol.11 No.1 Pe12186

关键词： CCL20/CCR6/ERK1/2/Elk-1/miR-181a-5p feedback loop;colorectal liver metastasis;extracellular vesicle;hepatic stellate cell;miR-181a-5p;tumour microenvironment.

摘要： Liver metastasis of colorectal cancer (CRLM) is the most common cause of CRC-related mortality, and is typically caused by interactions between CRC ce ...

作者： Chenglei Su  ^{1   2}, Yan Xiao  ^{2   3   4}, Guozhen Zhang  ², Lian Liang  ², Hui Li  ², Cheng Cheng  ², Tao Jin  ², Jennifer Bradley  ², Mary A Peberdy  ^{2   5}, Joseph P Ornato  ^{2   6}, Martin J Mangino  ^{2   7}, Wanchun Tang  ^{2   6} （Affiliations 1 Department of Emergency Medicine Center, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. 2 Weil Institute of Emergency and Critical Care Research, Virginia Commonwealth University, Richmond, VA. 3 Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Emergency Medicine, The Second Affiliated Hospital of Soochow University, Soochow, China. 5 Departments of Internal Medicine and Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA. 6 Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA. 7 Department of Surgery, Virginia Commonwealth University Health System, Richmond, VA.）

出处： Critical care medicine 2022 Vol.50 No.2 Pe189-e198

摘要： Objectives: To investigate the therapeutic potential and underlying mechanisms of exogenous nicotinamide adenine dinucleotide+ on postresuscitation my ...

作者： Rui Zhang  ^{1   2   3}, Xiaotong Sun  ⁴, Ya Li  ⁵, Wenzheng He  ⁶, Hongguang Zhu  ⁷, Baoshan Liu  ^{1   2   3}, Aiyuan Zhang  ^{1   2   3} （Affiliations 1 Department of Cardiology, 117907Weifang People\'s Hospital, the First Affiliated Hospital of Weifang Medical University, Weifang, China. 2 Cardiac Care Unit, 117907Weifang People\'s Hospital, the First Affiliated Hospital of Weifang Medical University, Weifang, China. 3 Cardiac Rehabilitation Centre, 117907Weifang People\'s Hospital, the First Affiliated Hospital of Weifang Medical University, Weifang, China. 4 Shandong Provincial Medicine and Health Key Laboratory of Clinical Anesthesia, Department of Anesthesiology, Weifang Medical University, Weifang, China. 5 Department of Cardiology, Shanghai General Hospital, School of Medicine, 12474Shanghai Jiaotong University, Hongkou District, Shanghai, China. 6 Intensive Care Unit, 117907Weifang People\'s Hospital, the First Affiliated Hospital of Weifang Medical University, Weifang, China. 7 Dental Department, 117907Weifang People\'s Hospital, the First Affiliated Hospital of Weifang Medical University, Weifang, China.）

出处： Journal of cardiovascular pharmacology and therapeutics 2022 Vol.27

关键词： angiotensin receptor-neprilysin inhibitor;efficacy;heart failure;sacubitril/valsartan;safety.

摘要： Heart failure (HF) is one of the leading causes of morbidity and mortality worldwide. Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibit ...

作者： Xiaoming Li ^{#  1}, Fang Li ^{#  2   3}, Xixi Zhang  ¹, Haiwei Zhang  ¹, Qun Zhao  ¹, Ming Li  ¹, Xiaoxia Wu  ¹, Lingxia Wang  ¹, Jianling Liu  ¹, Xuanhui Wu  ¹, Yangjing Ou  ¹, Mingyan Xing  ¹, Yue Zhang  ⁴, Jiangshan Deng  ⁵, Xiuzhe Wang  ⁵, Yan Luo  ⁴, Jinbao Li  ², Yuwu Zhao  ⁵, Haibing Zhang  ⁶ （Affiliations 1 CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. 2 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, China. 3 The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China. 4 Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People\'s Hospital, Shanghai, China. 6 CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. hbzhang@sibs.ac.cn.）

出处： Cell death and differentiation 2022

摘要： Caspase-8 is an initiator of death receptor-induced apoptosis and an inhibitor of RIPK3-MLKL-dependent necroptosis. In addition, caspase-8 has been im ...

作者： Zuyin Li  ^{1   2   3}, Guohe Song  ³, Dezhen Guo  ³, Zhijie Zhou  ⁴, Chen Qiu  ⁵, Chao Xiao  ⁶, Xiaoliang Wang  ⁷, Yupeng Wang  ³ （Affiliations 1 Department of Hepatobiliary Surgery, Peking University Organ Transplantation Institute, Peking University People\'s Hospital, Beijing, 100034, China. 2 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. 3 Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, China. 4 Department of General Surgery, Huashan Hospital North, Fudan University, Shanghai 201907, China. 5 Institute of Gallstone Disease, Center of Gallbladder Disease, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. 6 Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 20040, China. 7 Department of General Surgery, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, 201700, China.）

出处： Journal of Cancer 2022 Vol.13 No.2 P610-622

关键词： DNA replication;GINS2;cell cycle;immune cell infiltration..

摘要： Background: GINS2 has been reported to have prognostic value in several solid tumors other than hepatocellular carcinoma (HCC), and its influence on t ...