作者： Shasha Song  ¹, Yuanyuan Guo  ², Yuehua Yang  ³, Dehao Fu  ⁴ （Affiliations 1 College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, PR China. 2 Department of Pharmacy, Liyuan Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei 430077, PR China. 3 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. 4 Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, PR China. Electronic address: fudehao@sjtu.edu.cn.）

出处： Pharmacology & therapeutics 2022 P108168

关键词： Alpha-ketoglutarate;Autophagy;Cellular senescence;Gut microbiome;Hydrogen sulfide;Iron balance;Osteoporosis;Probiotics;Senolytics.

摘要： Osteoporosis, is the most common bone disorder worldwide characterized by low bone mineral density, leaving affected bones vulnerable to fracture. Bon ...

作者： Jing Ke  ¹, Kun Li  ¹, Tingyu Ke  ², Xu Zhong  ^{3   4}, Qidong Zheng  ⁵, Yufan Wang  ⁶, Li Li  ⁷, Yuancheng Dai  ⁸, Qijuan Dong  ⁹, Bangqun Ji  ¹⁰, Fengmei Xu  ¹¹, Juan Shi  ^{3   4}, Ying Peng  ^{3   4}, Yifei Zhang  ^{3   4}, Dong Zhao  ¹, Weiqing Wang  ^{3   4} （Affiliations 1 Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, China. 2 Department of Endocrinology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China. 3 Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the P. R. China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Internal Medicine, The Second People\'s Hospital of Yuhuan, Yuhuan, China. 6 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 7 Department of Endocrinology, Ningbo First Hospital, Ningbo, China. 8 Department of Internal Medicine of Traditional Chinese Medicine, Sheyang Diabetes Hospital, Yancheng, China. 9 Department of Endocrinology and Metabolism, People\'s Hospital of Zhengzhou Affiliated Henan University of Chinese Medicine, Zhengzhou, China. 10 Department of Endocrinology, Xingyi People\'s Hospital, Xinyi, China. 11 Department of Endocrinology and Metabolism, Hebi Coal (group). LTD. General Hospital, Hebi, China.）

出处： Journal of diabetes 2022 Vol.14 No.1 P64-72

关键词： 2型糖尿病;carotid plaque;sedentary;type 2 diabetes mellitus;久坐;颈动脉斑块.

摘要： Background: Atherosclerosis is a common complication in patients with type 2 diabetes (T2DM). Multiple factors are involved in the development and pro ...

作者： Chun Yang  ¹, Lijian Lang  ², Zhenghui He  ³, Jiyuan Hui  ⁴, Jiyao Jiang  ^{5   6}, Guo-Yi Gao  ⁷, Jun-Feng Feng  ⁸ （Affiliations 1 Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, People\'s Republic of China., Department of Neurosurgery, 160 Pujian Road, Shanghai, Shanghai, China, 200127; yc_life@163.com. 2 Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, 71140, Neurosurgery, Shanghai, Shanghai, China; lang_lijian@163.com. 3 Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, 71140, Neurosurgery, Shanghai, Shanghai, China; hezhenghui8@hotmail.com. 4 Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, 71140, Neurosurgery, Shanghai, Shanghai, China; weilaiyisheng@126.com. 5 Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, 71140, Department of Neurosurgery, Shanghai, China. 6 Shanghai Institute of Head Trauma, Shanghai, China; jiyaojiang@126.com. 7 Shanghai General Hospital, 12482, Department of Neurosurgery, Shanghai, China; gao3@sina.com. 8 Renji hospital, Shanghai Jiaotong University, Neurosurgery Department, No.1630, Dongfang Road, Shanghai, China, 200127; fengjfmail@163.com.）

出处： Journal of neurotrauma 2022

关键词： CLINICAL TRIAL;GERIATRIC BRAIN INJURY;TRAUMATIC BRAIN INJURY.

摘要： Increasing traumatic brain injury (TBI) among older adults constitutes a substantial socioeconomic burden, in step with the growing aging global popul ...

作者： Zhiying Yue^1,2;Xin Niu¹;Zengjin Yuan¹;Qin Qin¹;Wenhao Jiang³;Liang He³;Jingduo Gao¹;Yi Ding¹;Yanxi Liu¹;Ziwei Xu¹;Zhenxi Li⁴;Zhengfeng Yang^1,2;Rong Li¹;Xiwen Xue¹;Yankun Gao⁵;Fei Yue⁶;Zhang, Xiang H.-F⁶;Guohong Hu⁷;Yi Wang⁵;Yi Li⁶ （1 Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China 2 Precision Research Center for Refractory Diseases, Institute for Clinical Research, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 3 Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, China 4 Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, China 5 State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China 6 Lester and Sue Smith Breast Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas, USA 7 CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China）

出处： Journal of Clinical Investigation 2022 Vol.132 No.2 P1-19

关键词： Bone Biology;Bone disease;Breast cancer;Cell Biology;Signal transduction

摘要： Therapeutics targeting osteoclasts are commonly used treatments for bone metastasis; however, whether and how osteoclasts regulate premetastatic niche ...

作者： Hong Yao  ¹, Wanqun Xie  ¹, Yuting Dai  ², Yanting Liu  ¹, Weiting Gu  ¹, Jianfeng Li  ², Liang Wu  ², Jing Xie  ³, Weiwei Rui  ³, Bohan Ren  ⁴, Li Xue  ¹, Yijun Cheng  ¹, Shaojian Lin  ¹, Changsheng Li  ¹, Hao Tang  ¹, Yu Wang  ⁵, Meiqing Lou  ⁶, Xiaobiao Zhang  ⁷, Ronggui Hu  ⁸, Hanbing Shang  ¹, Jinyan Huang  ², Zhe Bao Wu  ^{1   4} （Affiliations 1 Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 5 Department of Neurosurgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 7 Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China. 8 State Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.）

出处： Neuro-oncology 2022 Pnoac053

关键词： Cushing\'s disease;PitNETs;TPIT;TRIM65;ubiquitination.

摘要： Background: Pituitary neuroendocrine tumors (PitNETs) are common intracranial tumors that are classified into seven histological subtypes, including l ...

作者： Fariha Kanwal  ¹, Mingming Ma  ², Muhammad Fayyaz Ur Rehman  ³, Fahim-Ullah Khan  ⁴, Shai E Elizur  ⁵, Aima Iram Batool  ⁶, Chi Chiu Wang  ⁷, Tahira Tabassum  ⁸, Changrui Lu  ⁹, Yao Wang  ¹⁰ （Affiliations 1 School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, Shanghai Key Laboratory of Ocular Fundus Diseases, National Clinical Research Center for Eye Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 3 Institute of Chemistry, University of Sargodha, Sargodha, Pakistan. 4 Department of Biotechnology, University of Science and Technology, Bannu, Pakistan. 5 IVF Unit, Department of Obstetrics and Gynecology, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. 6 Department of Zoology, University of Sargodha, Sargodha, Pakistan. 7 Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Shatin, Hong Kong, China. 8 Department of Pathology, Sargodha Medical College, University of Sargodha, Sargodha, Pakistan. 9 Department of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China. 10 Department of Assisted Reproduction, School of Medicine, Shanghai Ninth People\'s Hospital, Shanghai Jiao Tong University, Shanghai, China.）

出处： Frontiers in molecular biosciences 2022 Vol.8 P788279

关键词： aspirin;breast cancer;mesoporous silica;nanomedicine;nanoparticle.

摘要： Breast cancer affects more than 1 million women per year worldwide. Through this study, we developed a nanoparticle-based drug delivery system to targ ...

作者： Chun Yang ^{#  1   2}, Yuxiao Ma ^{#  1   2}, Li Xie  ³, Xiang Wu  ⁴, Jiyuan Hui  ^{1   2}, Jiyao Jiang  ^{1   2}, Guoyi Gao  ⁵, Junfeng Feng  ^{6   7} （Affiliations 1 Brain Injury Center, Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 2 Shanghai Institute of Head Trauma, Shanghai, China. 3 Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. gao3@sina.com. 6 Brain Injury Center, Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. fengjfmail@163.com. 7 Shanghai Institute of Head Trauma, Shanghai, China. fengjfmail@163.com.）

出处： Neurocritical care 2022

关键词： In-hospital mortality;Intensive care unit;Intracranial pressure monitoring;Length of stay;Traumatic brain injury.

摘要： Background: Although the current guidelines recommend the use of intracranial pressure (ICP) monitoring in patients with severe traumatic brain injury ...

作者： Jialing Zhang ^{#  1   2}, Li Cao ^{#  3}, Wenji Wang  ^{1   2}, Yu Huo  ^{2   4}, Yuanzheng Zheng  ^{2   4}, Fang Wu  ⁵, Yonghao Gui  ^{2   4} （Affiliations 1 Institute of Pediatrics, Children\'s Hospital of Fudan University, Shanghai, China. 2 NHC Key Laboratory of Neonatal Diseases, Fudan University, Shanghai, China. 3 Ultrasound Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. 4 Cardiovascular Center, Children\'s Hospital of Fudan University, Shanghai, China. 5 Department of Neonatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Journal of developmental origins of health and disease 2022 P1-9

关键词： Oxidative stress;antioxidants;cardiac dysfunction;prenatal overnutrition;ventricular remodeling.

摘要： Maternal overnutrition-induced fetal programming predisposes offspring to cardiovascular health issues throughout life. Understanding how these advers ...

作者： Zeyu Zhang  ¹, Yue Zhao  ², Yibo Liu  ¹, Xiaoyu Wang  ¹, Houshi Xu  ³, Yuanjian Fang  ¹, Anke Zhang  ¹, Cameron Lenahan  ⁴, Yujie Luo  ¹, Sheng Chen  ¹ （Affiliations 1 Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. 2 Department of Stomatology, The Children\'s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Health, Hangzhou, China. 3 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 Center for Neuroscience Research, Loma Linda University School of Medicine, Loma Linda, California, USA.）

出处： CNS neuroscience & therapeutics 2022

关键词： complication;functional outcome;hyperglycemia;neuroendocrine;stress;subarachnoid hemorrhage.

摘要： Background: Despite having an overall benign course, non-traumatic non-aneurysmal subarachnoid hemorrhage (naSAH) is still accompanied by a risk of cl ...

作者： Yiwen Zhu  ¹, Junjun Zhang  ¹, Chunlin Li  ², Guoying Deng  ², Junyan Li  ¹, Xijian Liu  ³, Bo Wan  ⁴, Ye Tian  ¹ （Affiliations 1 Department of Radiotherapy & Oncology, The Second Affiliated Hospital of Soochow University, Institute of Radiation Oncology, Soochow University, San Xiang Road No. 1055, Suzhou 215004, Jiangsu, China. 2 Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201620, China. 3 College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China. 4 Institute of Neuroscience, Soochow University, Renai Road No. 199, Suzhou 215123, Jiangsu, China.）

出处： ACS biomaterials science & engineering 2022

关键词： Se@SiO2 nanoparticles;hippocampus;radiation;reactive oxygen species.

摘要： Radiotherapy has been widely used to manage primary and metastatic brain tumors. However, hippocampal damage and subsequent cognitive dysfunction are ...