作者： Yi Zhang  ^{1   2   3}, Min Ji  ⁴, Jin-Yan Zhao  ⁵, Hua-Feng Wang  ^{1   2   3   6}, Chong-Wu Wang  ⁷, Wei Li  ⁴, Jing-Jing Ye  ⁴, Fei Lu  ⁴, Li-Hui Lin  ⁵, Yan-Ting Gao  ⁵, Jie Jin  ^{1   2   3   6}, Li Li  ⁵, Chun-Yan Ji  ⁴, Joan Ballesteros  ⁸, Hong-Hu Zhu  ^{1   2   3   6} （Affiliations 1 Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. 2 Zhejiang Province Key Laboratory of Hematology Oncology Diagnosis and Treatment, Hangzhou, China. 3 Zhejiang University Cancer Center, Hangzhou, China. 4 Department of Hematology, Qilu Hospital, Shandong University, Jinan, China. 5 Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Zhejiang Laboratory for Systems & Precision Medicine, Zhejiang University Medical Center, Hangzhou, China. 7 R & D Department, Hosea Medical Technology (Beijing) Co., Ltd., Beijing, China. 8 R & D Department, Vivia Biotech, Madrid, Spain.）

出处： Frontiers in oncology 2022 Vol.11 P793773

关键词： acute myeloid leukemia;chemosensitivity;complete remission;ex vivo drug sensitivity test;precision medicine.

摘要： We evaluated the predictive value of the ex-vivo PharmaFlow PM platform in measuring the pharmacological activity of drug combinations consisting of 2 ...

作者： Juan Liu  ¹, Xin Qi  ², Xiao-Hong Wang  ³, Hong-Sheng Miao  ¹, Zi-Chao Xue  ⁴, Le-Le Zhang  ⁵, San-Hu Zhao  ¹, Liang-Hao Wu  ², Guo-Yi Gao  ¹, Mei-Qing Lou  ¹, Cheng-Qing Yi  ² （Affiliations 1 Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. 2 Department of Orthopaedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No. 2800 Gongwei Road, Huinan Town, Pudong, Shanghai 201399, China. 3 Department of Operating Room, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No. 2800 Gongwei Road, Huinan Town, Pudong, Shanghai 201399, China. 4 Department of Orthopaedics, Qingdao Municipal Hospital, Qingdao 266001, China. 5 Department of Nursing, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, No. 2800 Gongwei Road, Huinan Town, Pudong, Shanghai 201399, China.）

出处： Journal of clinical medicine 2022 Vol.11 No.2 P395

关键词： BMSCs;MEG3;bone regeneration;long non-coding RNA;skull defect.

摘要： Background: Previous studies have demonstrated that long non-coding RNA maternally expressed gene 3 (MEG3) emerged as a key regulator in development a ...

作者： Wenting Hou  ¹, Lihong Lu  ¹, Xue Li  ¹, Minli Sun  ², Minmin Zhu  ³, Changhong Miao  ⁴ （Affiliations 1 Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. 2 Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: sunminli@sina.com. 3 Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. Electronic address: zhu_mm@126.com. 4 Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: miao_chh@126.com.）

出处： Cellular signalling 2022 Vol.92 P110263

关键词： Diabetic nephropathy;Endothelial adhesive molecules;IRAK1;KMT5A;c-Myc.

摘要： Diabetic nephropathy (DN) is a common vascular complication of diabetes. Endothelial adhesion molecules are involved in physiopathology of DN. Interle ...

作者： Runzhi Huang  ^{1   2   3}, Mingxiao Li  ^{1   3}, Zhiwei Zeng  ^{1   3}, Jie Zhang  ³, Dianwen Song  ⁴, Peng Hu  ^{1   2}, Penghui Yan  ¹, Shuyuan Xian  ⁵, Xiaolong Zhu  ^{1   3}, Zhengyan Chang  ⁶, Jiayao Zhang  ⁷, Juanru Guo  ⁷, Huabin Yin  ⁴, Tong Meng  ^{4   8}, Zongqiang Huang  ^{1   2} （Affiliations 1 Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 2 Division of Spine, Department of Orthopedics, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China. 3 Zhengzhou University School of Medicine, Zhengzhou University, Zhengzhou, China. 4 Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China. 5 Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. 6 Tongji University School of Medicine, Shanghai, China. 7 Department of Pathology, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, China. 8 Tongji University School of Mathematical Sciences, Tongji University, Shanghai, China.）

出处： Cancer control : journal of the Moffitt Cancer Center 2022 Vol.29

关键词： alternative splicing;metastasis;prediction model;skin cutaneous melanoma.

摘要： Skin cutaneous melanoma (SKCM) is a type of highly invasive cancer originated from melanocytes. It is reported that aberrant alternative splicing (AS) ...

作者： Gaozhen Jia  ¹, Xingjie Wang  ¹, Wenbo Wu  ¹, Yu Zhang  ¹, Shaoan Chen  ¹, Jing Zhao  ¹, Wei Zhao  ¹, Weiguo Li  ¹, Xiaowen Sun  ², Bangmin Han  ³ （Affiliations 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Wujin Road 85, Shanghai, 200080, China; Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. 2 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Wujin Road 85, Shanghai, 200080, China; Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. Electronic address: sunxiaow1973@163.com. 3 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Wujin Road 85, Shanghai, 200080, China; Institute of Urology, Shanghai Jiao Tong University, Shanghai, 200080, China. Electronic address: hanbm@163.com.）

出处： International immunopharmacology 2022 Vol.107 P108586

关键词： LXA4;METTL3;Macrophages;Prostate cancer;STAT6.

摘要： Tumor-associated macrophages (TAMs) are major innate immune cells that play crucial roles in prostate cancer onset and progression. Recently, increasi ...

作者： Min Chen ^{#  1}, Chencheng Yao ^{#  2}, Yingying Qin ^{#  3}, Xiuhong Cui  ⁴, Peng Li  ², Zhiyong Ji  ², Limei Lin  ^{4   5   6}, Haowei Wu  ^{4   5   6}, Zhi Zhou  ⁷, Yaoting Gui  ⁸, Zheng Li  ⁹, Fei Gao  ^{10   11   12} （Affiliations 1 Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, P. R. China. 2 Department of Andrology, the Center for Men\'s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China. 3 Center for Reproductive Medicine of Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, P. R. China. 4 State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China. 5 University of Chinese Academy of Sciences, Beijing, P. R. China. 6 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. 7 School of Life Science and Technology, ShanghaiTech University, Shanghai, P. R. China. 8 Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, P. R. China. guiyaoting2007@aliyun.com. 9 Department of Andrology, the Center for Men\'s Health, Urologic Medical Center, Shanghai Key Laboratory of Reproductive Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China. lizhengboshi@163.com. 10 State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, P. R. China. gaof@ioz.ac.cn. 11 University of Chinese Academy of Sciences, Beijing, P. R. China. gaof@ioz.ac.cn. 12 Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China. gaof@ioz.ac.cn.）

出处： Signal transduction and targeted therapy 2022 Vol.7 No.1 P1

作者： Chen Feng  ^{1   2   3}, Yan Yang  ^{2   3}, Lixiao Chen  ¹, Ruixiang Guo  ^{2   3}, Huayang Liu  ^{2   3}, Chaojie Li  ^{2   3}, Yan Wang  ^{2   3}, Pin Dong  ¹, Yanzhong Li  ^{2   3} （Affiliations 1 Department of Otolaryngology Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 2 Department of Otorhinolaryngology, Qilu Hospital, Shandong University Cheeloo College of Medicine, Jinan, China. 3 NHC Key Laboratory of Otorhinolaryngology (Shandong University), Jinan, China.）

出处： Frontiers in endocrinology 2022 Vol.13 P812974

关键词： IIEF-5 questionnaire;erectile dysfunction;obstructive sleep apnea;polysomnography;sex hormones.

摘要： Background: Obstructive sleep apnea (OSA) is a common and severe social problem. Erectile dysfunction (ED) is an important health concern. The prevale ...

作者： Rong Wang  ¹, Lingbin Che  ², Qian Feng  ¹, Kaiyong Cai  ¹ （Affiliations 1 Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400044, China. 2 Department of Orthopedics Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China.）

出处： ACS applied materials & interfaces 2022

关键词： alendronate;amphoteric copolymer;bone regeneration;hydrogel;mesenchymal stem cells.

摘要： Bone tissue scaffolds with good bulk or surface osteoconductivity are always pursued by biomaterial scientists. In this paper, we design a tough and f ...

作者： Zhixian Yao ^{#  1   2}, Zhong Zheng ^{#  2}, Xinyi Zheng ^{#  3}, Hantao Wu  ¹, Weiguang Zhao  ¹, Xingyu Mu  ¹, Feng Sun  ¹, Ke Wu  ², Junhua Zheng  ^{1   2} （Affiliations 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. 2 Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, China.）

出处： Oxidative medicine and cellular longevity 2022 Vol.2022 P9039732

摘要： Renal cell carcinoma (RCC) is a disease characterized by excessive administration complexity because it exhibits extraordinary nonuniformity among dis ...

作者： Xiao Zhou  ^{1   2}, Yu Cai  ^{1   2}, Jun Yang  ^{1   2}, Yin Tong  ^{1   2}, Huiying Qiu  ^{1   2}, Chongmei Huang  ^{1   2}, Kun Zhou  ^{1   2}, Xiaowei Xu  ^{1   2}, Jiahua Niu  ^{1   2}, Xinxin Xia  ^{1   2}, Ying Zhang  ^{1   2}, Chang Shen  ^{1   2}, Yu Wei  ^{1   2}, Xianmin Song  ^{1   2}, Liping Wan  ^{1   2} （Affiliations 1 Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Engineering Technology Research Center of Cell Therapy and Clinical Translation, Shanghai Science and Technology Committee (STCSM), Shanghai, China.）

出处： Cell transplantation 2022 Vol.31

关键词： absolute lymphocyte count;anti-thymocyte globulin;haploidentical;peripheral blood stem cell transplantation;relapse;survival.

摘要： Standard anti-thymocyte globulin (ATG) weight-based dosing often resulted in highly variable ATG exposure, which had profound effects on relapse and s ...