作者： Zhihong Zhao¹;Beibei Li²;Jun Liu³CA1 （1 School of Rail Transit Engineering, Nanjing Institute of Industry Technology, 210023, Nanjing, China; 2 School of Computer and Information Engineering, Shanghai Polytechnic University, 201209, Shanghai, China; 3 Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, 200080, Shanghai, China）

出处： Journal of Combinatorial Optimization 2021 Vol.42 No.4 P937-947

关键词： Sampling;Genetic algorithm;Electron microscope;Fitting

摘要： This paper presents a method to realize fitting PDB of protein molecule PB1-p62 into its EM in PB1 domain, based on rotation group SO(3) theory. An im ...

作者： Ke Si;Da Lu;Jianbo Tian （Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China Department of Vascular Surgery, Shanghai General Hospital, Shanghai, People’s Republic of China Institute of Information Engineering, Chinese Academy of Sciences, Beijing, People’s Republic of China）

出处： PeerJ 2021 Vol.9 Pe12682

关键词： Abdominal aortic aneurysm;Differentially expressed genes;Micro RNAs;Circular RNAs

摘要： Background Abdominal aortic aneurysm (AAA) is a disease commonly seen in the elderly. The aneurysm diameter increases yearly, and the larger the AAA t ...

作者： Huidan Lin¹;Qun Li²CA1;Xueguo Xu³;Ying Zhang² （1 Economic Management Institute, Shanghai Polytechnic University, 201209, Shanghai, China; 2 Shanghai General Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China; 3 School of Management, Shanghai University, 200444, Shanghai, China）

出处： Journal of Combinatorial Optimization 2021 Vol.42 No.4 P848-865

关键词： Drug consumables;SPD;Material distributors;Theory of modern scheduling

摘要： This paper studies the supply chain management of medical supply-processing-distribution (SPD) and models the logistics scheduling of drugs and consum ...

作者： Guo, Weihong¹;Zhang, Xiaoxing²;Lin, Longshuai¹;Wang, Hongjie¹;He, Enjun¹;Wang, Gangyang¹;Zhao, Qinghua¹ （1 Department of Orthopaedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University , No. 100, Hai Ning Road, Shanghai 200080, China 2 Department of Orthopedic Surgery, Chongqing University Central Hospital , Chongqing 400000, China）

出处： Journal of Biochemistry 2021 Vol.170 No.2 P275-287

关键词： apoptosis;autophagy;disulfiram/copper;osteosarcoma;ROS/JNK signalling pathway

摘要： Given the huge cost, long research and development (R&D) time and uncertain side effects of discovering new drugs, drug repositioning of those approve ...

作者： Yan, Yuanye ¹;Wang, Yisai ²;Ding, Jie ³;Lu, Li ¹;Ke, Gen-Jie ^1,4;Dong, Kai ¹ （1 Department of Ophthalmology, Eye Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China 2 Department of Ophthalmology, Anhui Medical University, Hefei, China 3 Department of Ophthalmology, The Second People\'s Hospital of Hefei, Hefei, China 4 Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China）

出处： Ophthalmic Research 2021 Vol.10 Suppl P587-594

关键词： Apoptosis;Autophagy;Mucolipin synthetic agonist 1;Reactive oxygen species;Retinal detachment;Transient receptor potential mucolipin 1

摘要： Objective: In this study, we used a rat model of retinal detachment (RD) to investigate the effects of transient receptor potential mucolipin 1 (TRPML ...

作者： Meng, Tong;Huang, Runzhi;Jin, Jiali;Gao, Jianxuan;Liu, Fuyan;Wei, Ziheng;Xu, Xiaowen;Chang, Zhengyan;Lin, Jun;Ta, Na;Huang, Zongqiang;Yin, Huabin;Zhou, Wang;Song, Dianwen （Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Tongji University Cancer Center, Shanghai Tenth People\'s Hospital, School of Medicine, Tongji University, Shanghai, China Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Tongji University, Shanghai, China Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Biomarker Technologies Corporation, Beijing, China Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Tongji University, Shanghai, China Department of Pathology, Shanghai Tenth People\'s Hospital, Tongji University School of Medicine, Shanghai, China Department of Pathology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Department of Pathology, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China Departments of Neurovascular Center, Shanghai Changhai Hospital, Navy Medical University, Shanghai, China The Musculoskeletal Laboratory, Institute of Biotechnology, University of Shanghai for Science and Technology, Shanghai, China）

出处： Neuro-Oncology 2021 Vol.23 No.10 P1709-1722

关键词： bone microenvironment;CA2;chordoma;Hi-C;multi-omics analysis.

作者： Yu;Li;Jiang;Hsu;Hsu;Zhang;Wang （Affiliations: 1: Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China 2: Department of Urology, Shanghai ZhongShan Hospital, Fudan University School of Medicine, Shanghai 200123, P.R. China 3: Department of Surgery, Shanghai Ruibo Clinic, Shanghai 200023, P.R. China 4: Department of VIP Clinical, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, P.R. China 5: Department of Endocrinology, Shanghai Tianyou Hospital, School of Medicine, Tongji University, Shanghai 200331, P.R. China）

出处： Oncology Reports 2021 Vol.46 No.2 P1-9

摘要： Chemotherapy resistance is one of the major challenges in the treatment of liver cancer (LC). The present study aimed to investigate the potential rol ...

作者： Yuting Gu^1,2,3;Hong Zhou^4,3;Hongshuang Yu²;Wanlin Yang⁵;Bei Wang²;Fengtao Qian²;Yiji Cheng¹;Shan He⁵;Xiaonan Zhao⁵;Linqiao Zhu⁵;Yanyun Zhang^2,5CA1;Min Jin^1,2CA2;Eryi Lu¹CA3 （1 Department of Stomatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; 2 Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200032, China; 3 These authors contributed equally; 4 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; 5 Children’s Hospital of Soochow University, Institutes for Translational Medicine, State Key Laboratory of Radiation Medicine and Protection, Medical College of Soochow University, Soochow University, Suzhou, Jiangsu 215006, China）

出处： Molecular Therapy - Nucleic Acids 2021 Vol.26 P1173-1185

关键词： miR-99a;EAE;T-cell differentiation;glycolysis;mTOR;TGF-β

摘要： Multiple microRNAs exhibit diverse functions to regulate inflammatory and autoimmune diseases. MicroRNA-99a (miR-99a) has been shown to be involved in ...

作者： Cheng Hu^1,2;Liyuan Yin^3,2;Zhiyao Chen¹;Richard T. Waldron^4,5;Aurelia Lugea^4,5;Yiyun Lin⁶;Xiaoqian Zhai³;Li Wen⁷;Yuan-Ping Han⁸;Stephen J. Pandol^4,5;Lihui Deng¹CA1;Qing Xia¹CA2 （1 Department and Laboratory of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Center and West China-Liverpool Biomedical Research Center, West China Hospital, Sichuan University, Chengdu, China; 2 These authors contributed equally to this work.; 3 Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, China; 4 Department of Medicine and Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 5 Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; 6 Graduate School of Biomedical Sciences, UT MD Anderson Cancer Center, University of Texas, Houston, TX, United States; 7 Department of Gastroenterology and Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 8 Center for Growth, Metabolism and Aging, College of Life Sciences, Sichuan University, Chengdu, China）

出处： Computational and Structural Biotechnology Journal 2021 Vol.19 P6375-6385

关键词： Pancreatic stellate cell;Acute pancreatitis;Recurrent acute pancreatitis;Chronic pancreatitis;SPARC

摘要： Chronic pancreatitis (CP) is characterized by irreversible fibro-inflammatory changes induced by pancreatic stellate cell (PSC). Unresolved or recurre ...

作者： Ning Li MD¹;Youzhong Zhang²;Jing Wang³;Jianqing Zhu⁴;Li Wang MB⁵;Xiaohua Wu MD, PhD⁶;Desheng Yao MD⁷;Qiang Wu MD⁸;Jihong Liu⁹;Junying Tang MD¹⁰;Rutie Yin MD¹¹;Guonan Zhang MD¹²;Ge Lou¹³;Ruifang An MD, PhD¹⁴;Xiaoping Xia¹⁵;Qingshui Li¹⁶;Yaping Zhu MD¹⁷;Zheng Hong¹⁸;Xinfeng Yang¹⁹;Yuanjing Hu MD PhD²⁰;Xin Zhang²¹;Xiaoyun Wan MD, PhD²²;Jing Qu²³;Ben Zhang²³;Lingying Wu MD¹ （1 National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; 2 Qilu Hospital of Shandong University, Shandong, China; 3 The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China; 4 Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Beijing, China; 5 Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, China; 6 Fudan University Affiliated Cancer Hospital, Shanghai, China; 7 Guangxi Medical University Affiliated Tumor Hospital, Nanning, Guangxi, China; 8 Jiangsu Cancer Hospital, NanJing, JiangSu, China; 9 Sun Yat-Sen University Cancer Center, Guangzhou, China; 10 The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; 11 West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China; 12 Sichuan Cancer Hospital, Chengdu, China; 13 Harbin Medical University Cancer Hospital, Harbin, China; 14 The First Affiliated Hospital of Xi\'an Jiaotong University, Xi\'an, China; 15 Anhui Provincial Cancer Hospital, Anhui, China; 16 Shandong Cancer Hospital and Institute, Shandong, China; 17 Shanghai General Hospital, Shanghai, China; 18 Beijing Cancer Hospital, Beijing, China; 19 Jiangxi Cancer Hospital, Jiangxi, China; 20 Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, China; 21 Liaoning Cancer Hospital & Insititute, Liaoning, China; 22 Woman\'s Hospital, School of Medicine, Zhejiang University, Hangzhou, China; 23 Jiangsu Hengrui Medicine Co. Ltd, Shanghai, China）

出处： Gynecologic Oncology 2021 Vol.162 Suppl 1 PS57-S58

摘要： Objectives: Fuzuloparib (formerly fluzoparib), a poly (ADP-ribose) polymerase inhibitor, has shown promising antitumor activity and acceptable safety ...