作者： Yanhong Hou  ^{1   2   3}, Felix Bock  ^{1   4}, Deniz Hos  ^{1   4}, Claus Cursiefen  ^{1   4} （Affiliations 1 Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany. 2 Department of Ophthalmology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China. 3 Shanghai Key Laboratory of Ocular Fundus Disease, National Clinical Research Center for Eye Diseases, Shanghai 200080, China. 4 Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50937 Cologne, Germany.）

出处： Cells 2021 Vol.10 No.7 P1661

关键词： corneal collagen crosslinking;corneal transplantation;fine needle diathermy;graft rejection;lymphangioregression;lymphatic trafficking;preconditioning.

摘要： (Lymph)angiogenesis into the cornea prior to and after corneal transplantation is a critical risk factor for allograft rejection. Lymphatic vessels ev ...

作者： Feng Liang^1,2;Yi Wang¹ （1 Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2 Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China）

出处： American Journal of Physiology: Lung Cellular & Molecular Physiology 2021 Vol.320 No.1 P1-12

关键词： atrial fibrillation;coronary heart disease;risk factors;treatment strategies;vicious cycle

摘要： The population suffering from coronary heart disease (CHD) complicated by atrial fibrillation (AF) is rising rapidly. A strong correlation between the ...

作者： Kanru Yu  ¹ , Hao Li  ¹ , Zhongyi Jiang  ¹ , Han-Jen Hsu  ² , Hsing-Chun Hsu  ³ , Yumei Zhang  ⁴ , Kunwei Wang  ⁵ （Affiliations 1 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China. 2 Department of Urology, Shanghai ZhongShan Hospital, Fudan University School of Medicine, Shanghai 200123, P.R. China. 3 Department of Surgery, Shanghai Ruibo Clinic, Shanghai 200023, P.R. China. 4 Department of VIP Clinical, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200123, P.R. China. 5 Department of Endocrinology, Shanghai Tianyou Hospital, School of Medicine, Tongji University, Shanghai 200331, P.R. China.）

出处： Oncology reports 2021 Vol.46 No.2 P162

关键词： Yes‑associated protein;cisplatin;liver cancer;microRNA‑375;resistance.

摘要： Chemotherapy resistance is one of the major challenges in the treatment of liver cancer (LC). The present study aimed to investigate the potential rol ...

作者： Shuyu Xiong  ^{1   2   3   4} , Mingming Ma  ^{1   2   3   4} , Yupeng Xu  ^{1   2   3   4} , Fang Wei  ^{1   2   3   4} , Qing Gu  ^{1   2   3   4} , Xiangui He  ⁵ , Xun Xu  ^{1   2   3   4} （Affiliations 1 Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, P.R. China. 2 Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai 200080, P.R. China. 3 Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai 200080, P.R. China. 4 National Clinical Research Center for Eye Diseases, Shanghai 200080, P.R. China. 5 Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai 200040, P.R. China.）

出处： Experimental and therapeutic medicine 2021 Vol.21 No.5 P451

关键词： Akt;Erk;excitotoxicity;neuroprotection;peptide.

摘要： Excitotoxic neuronal injury is associated with numerous acute and chronic neurological disorders, such as Alzheimer\'s disease and glaucoma. Neuroprot ...

作者： Lu Xie  ¹, Jie Xu  ¹, Wei Guo  ¹, Zhen Wang  ², Yang Yao  ³, Jianmin Li  ⁴, Jianhua Lin  ⁵, Jianru Xiao  ⁶, Xiuchun Yu  ⁷, Weibin Zhang  ⁸, Zhendong Cai  ⁹, Yingqi Hua  ⁹, Jing Chen  ¹⁰, Zengwu Shao  ¹⁰, Di Wu  ¹¹, Sujia Wu  ¹², Zhongqi Tu  ¹³, Xiaojing Zhang  ¹⁴ （Affiliations 1 Musculoskeletal Tumor Center, Peking University People\'s Hospital, Beijing, China. 2 Orthopedic Oncology, Xijing Hospital Air Force Medical University of PLA (The Fourth Military Medical University), Xi\'an, China. 3 Medical Oncology, Shanghai Sixth People\'s Hospital, Shanghai, China. 4 Orthopedic Oncology, Qilu Hospital of Shandong University, Jinan, China. 5 Musculoskeletal Tumor Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. 6 Orthopedic Oncology, Shanghai Changzheng Hospital, Shanghai, China. 7 Orthopedic Oncology, Jinan Military General Hospital, Jinan, China. 8 Orthopedic Oncology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China. 9 Orthopedic Oncology, Shanghai General Hospital, Shanghai, China. 10 Orthopedic Oncology and Medical Oncology, Wuhan Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China. 11 Medical Oncology, The First Affiliated Hospital of Jilin University, Changchun, China. 12 Orthopedic Oncology, General Hospital of Eastern Theater Command, Nanjing, China. 13 Orthopedic Oncology, Huaxi Hospital West China School of Medicine/West China Hospital of Sichuan University (WCSM/WCH), Chengdu, China. 14 Musculoskeletal Tumor Center, Liaoning Cancer Hospital & Institute, Shenyang, China.）

出处： Frontiers in oncology 2021 Vol.11 P696865

关键词： apatinib;osteosarcoma;prophylaxis;toxicity;treatment.

摘要： Four prospective trials have reported apatinib-related efficacy in osteosarcoma, with a high response rate of 43.2%. Currently, Adverse Events (AEs) h ...

作者： Lingtong Hou MS;Huiqin Zhang MS;Xiaomei Sun PhD;Qianqian Liu MS;Tingfeng Chen PhD;Yong Liu PhD;Xiaodong Jiang PhD;Shengyu Yao MS （Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, China Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Oncology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, China Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China）

出处： Technology in Cancer Research & Treatment 2021 Vol.20

摘要： Purpose: To evaluate the dosimetric accuracy of the default couch model of the QFix kVue TM Calypso couch top in the treatment planning system. Method ...

作者： Bingqiong Wang;Jialing Zhou;Xiaoning Wu;Yameng Sun;Lei Li;Ping Li;Minghui Li;Wei Jiang;Mingyi Xu;Bo Feng;Xiaoyuan Xu;Jilin Cheng;Wen Xie;Tao Han;Xiaozhong Wang;Hai Li;Hongxin Piao;Shanshan Wu;Yiwen Shi;Shuyan Chen;Yuanyuan Kong;Hong Ma;Xiaojuan Ou;Jidong Jia;Hong You （Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China <<#>> orcid.org/0000-0001-5075-6656 Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China <<#>> Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China <<#>> Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China <<#>> Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China <<#>> Department of Hepatology, Tianjin Second People\'s Hospital, Tianjin, China <<#>> Liver Disease Center, Beijing Ditan Hospital, Capital Medical University, Beijing, China <<#>> orcid.org/0000-0002-9354-6699 Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China <<#>> Department of Gastroenterology and Hepatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China <<#>> Hepatology Institute, Peking University People\'s Hospital, Beijing, China <<#>> Department of Infectious Disease, Peking University First Hospital, Beijing, China <<#>> Department of Gastroenterology, Shanghai Public Health Clinical Center, Shanghai, China <<#>> orcid.org/0000-0002-7314-8175 Liver Disease Center, Beijing Ditan Hospital, Capital Medical University, Beijing, China <<#>> Department of Hepatology, Tianjin Third Central Hospital, Tianjin Medical University, Tianjin, China <<#>> Department of Hepatology, Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital, Urumqi, Xinjiang, China <<#>> Department of Gastroenterology, Tianjin Xiqing Hospital, Tianjin, China <<#>> Department of Infectious Diseases, Affiliated Hospital of Yanbian University, Yanji, China <<#>> Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China <<#>> orcid.org/0000-0002-7049-9551 Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China <<#>> Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China <<#>> orcid.org/0000-0002-2586-1443 Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China <<#>> orcid.org/0000-0002-2805-3919 Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China <<#>> Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China <<#>> Corresponding Author jia_jd@ccmu.edu.cn Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China Correspondence Jidong Jia and Hong You, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Xicheng District, Beijing, China. Email: jia_jd@ccmu.edu.cn and youhongliver@ccmu.edu.cn <<#>> Corresponding Author youhongliver@ccmu.edu.cn orcid.org/0000-0001-9409-1158 Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China Correspondence Jidong Jia and Hong You, Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Xicheng District, Beijing, China. Email: jia_jd@ccmu.edu.cn and youhongliver@ccmu.edu.cn）

出处： Liver International 2021 Vol.41 No.2 P369-377

关键词： Baveno VI;hepatitis B virus;high‐risk varices;platelets

摘要： Background & Aims Non‐invasive assessment criteria to rule out high‐risk varices (HRV) in compensated hepatitis B virus (HBV) cirrhosis on antiviral ...

作者： Shaojie Chen  ¹ , Helmut Pürerfellner  ² , Christian Meyer  ³ , Philipp Sommer  ⁴ , Márcio Galindo Kiuchi  ⁵ , Martin Martinek  ² , Piotr Futyma  ⁶ , Simone Zanchi  ⁷ , Lin Zhu  ⁸ , Alexandra Schratter  ⁹ , Jiazhi Wang  ¹⁰ , Willem-Jan Acou  ¹¹ , Shaowen Liu  ¹² , Zhiyu Ling  ¹³ , Yuehui Yin  ¹³ , Feifan Ouyang  ¹⁴ , Julian K R Chun  ¹ , Boris Schmidt  ¹⁵ （Affiliations 1 Cardioangiologisches Centrum Bethanien (CCB), Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Akademisches Lehrkrankenhaus der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany; Die Sektion Medizin, Universität zu Lübeck, Lübeck, Germany. 2 Department für Kardiologie und Elektrophysiologie, Akademisches Lehrkrankenhaus, Ordensklinikum Linz Elisabethinen, Linz, Austria. 3 Department of Cardiology, cNEP, Cardiac Neuro- & Electrophysiology Research Group, University Heart & Vascular Center Hamburg, University Hospital Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany; Department of Cardiology, Evangelical Hospital Düsseldorf, Düsseldorf, Germany; Heinrich-Heine-University Hospital Düsseldorf, Düsseldorf, Germany. 4 Klinik für Elektrophysiologie/Rhythmologie, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany. 5 School of Medicine-Royal Perth Hospital Unit, University of Western Australia, Perth, Australia. 6 St. Joseph\'s Heart Rhythm Center, Rzeszów, Poland. 7 Division of Cardiology, Poliambulanza Institute Hospital Foundation, Brescia, Italy. 8 Medizinisch-Geriatrische Klinik, Agaplesion Markus Krankenhaus, Akademisches Lehrkrankenhaus der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany. 9 Medizinische Abteilung mit Kardiologie, Krankenhaus Hietzing Wien, Vienna, Austria. 10 Intensivmedizin, Charité - Universitätsmedizin Berlin, Berlin, Germany. 11 Department of Cardiology, AZ Delta, Roeselare, Belgium. 12 Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 13 Department of Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. 14 Klinik und Poliklinik für Kardiologie, Universitäres Herz und Gefäßzentrum, Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg, Germany. 15 Cardioangiologisches Centrum Bethanien (CCB), Kardiologie, Medizinische Klinik III, Agaplesion Markus Krankenhaus, Akademisches Lehrkrankenhaus der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany.）

出处： European heart journal. Cardiovascular pharmacotherapy 2021 Ppvab032

关键词： anticoagulation;atrial fibrillation;liver disease;liver dysfunction;stroke.

摘要： Aims: Anticoagulation for atrial-fibrillation (AF) patients with liver-disease represents a clinical dilemma. We sought to evaluate the efficacy/safet ...

作者： Jesus D Melgarejo  ^{1   2} , Lutgarde Thijs  ¹ , Dong-Mei Wei  ¹ , Michael Bursztyn  ³ , Wen-Yi Yang  ⁴ , Yan Li  ⁵ , Kei Asayama  ^{6   7} , Tine W Hansen  ⁸ , Masahiro Kikuya  ⁶ , Takayoshi Ohkubo  ^{6   7} , Eamon Dolan  ⁹ , Katarzyna Stolarz-Skrzypek  ¹⁰ , Yi-Bang Cheng  ⁵ , Valérie Tikhonoff  ¹¹ , Sofia Malyutina  ¹² , Edoardo Casiglia  ¹¹ , Lars Lind  ¹³ , Edgardo Sandoya  ¹⁴ , Jan Filipovský  ¹⁵ , Krzysztof Narkiewicz  ¹⁶ , Natasza Gilis-Malinowska  ¹⁶ , Kalina Kawecka-Jaszcz  ¹⁰ , José Boggia  ¹⁷ , Ji-Guang Wang  ⁵ , Yutaka Imai  ⁷ , Peter Verhamme  ¹⁸ , Sander Trenson  ¹⁹ , Stefan Janssens  ¹⁹ , Eoin O\' Brien  ²⁰ , Gladys E Maestre  ^{2   21   22} , Benjamin Gavish  ²³ , Jan A Staessen  ^{24   25} , Zhen-Yu Zhang  ¹ （Affiliations 1 Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium. 2 Laboratory of Neurosciences, Faculty of Medicine, University of Zulia, Maracaibo, Zulia, Venezuela. 3 Faculty of Medicine, Hebrew University, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel. 4 Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 5 Center for Epidemiological Studies and Clinical Trials and Center for Vascular Evaluation, Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 6 Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan. 7 Tohoku Institute for Management of Blood Pressure, Sendai, Japan. 8 Steno Diabetes Center Copenhagen, Gentofte and Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark. 9 Stroke and Hypertension Unit, Blanchardstown, Dublin, Ireland. 10 First Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland. 11 Department of Medicine, University of Padova, Padova, Italy. 12 Institute of Internal and Preventive Medicine, Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, Novosibirsk, Russian Federation. 13 Section of Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. 14 Asociación Española Primera de Socorros Mutuos, Montevideo, Uruguay. 15 Faculty of Medicine, Charles University, Pilsen, Czech Republic. 16 Department of Hypertension, Medical University of Gdańsk, Gdańsk, Poland. 17 Centro de Nefrología and Departamento de Fisiopatología, Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay. 18 Centre for Molecular and Vascular Biology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium. 19 Division of Cardiology, Department of Internal Medicine, University Hospitals Leuven, Leuven, Belgium. 20 Conway Institute, University College Dublin, Dublin, Ireland. 21 Department of Neurosciences and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA. 22 Alzheimer´s Disease Resource Center for Minority Aging Research, University of Texas Rio Grande Valley, Brownsville, TX, USA. 23 Yazmonit Ltd., Jerusalem, Israel. 24 Research Institute Alliance for the Promotion of Preventive Medicine, Mechelen, Belgium. 25 Biomedical Science Group, Faculty of Medicine, University of Leuven, Leuven, Belgium.）

出处： American journal of hypertension 2021 Phpab048

摘要： Background: Pulse pressure (PP) reflects the age-related stiffening of the central arteries, but no study addressed the management of the PP-related r ...

作者： Tianqin Wang¹;Chaoyang Zhang^2,3;Hai Xie⁴;Mengmeng Jiang¹;Haibin Tian⁴;Lixia Lu⁴;Guo-Tong Xu⁴CA1;Lin Liu¹CA2;Jingfa Zhang^2,3CA3 （1 Department of Ophthalmology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 160 Pujian Road, Pudong New District, 200127, Shanghai, China; 2 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University, 100 Haining Road, Hongkou District, 200080, Shanghai, China; 3 National Clinical Research Center for Eye Diseases;Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China; 4 Tongji Eye Institute, Tongji University School of Medicine, 1239 Siping Road, Medical School Building, Room 623, 200092, Shanghai, China）

出处： Eye and Vision 2021 Vol.8 No.1 P13

关键词： Diabetic retinopathy;Diabetic macular edema;Müller cell;Anti-VEGF;Intracellular edema

摘要： Background Although vascular endothelial growth factor A (VEGF-A) is known to play a key role in causing retinal edema, whether and how VEGF-A induce ...