作者： Peng Gu  ¹, Lei Zhang  ², Ruitao Wang  ¹, Wentao Ding  ¹, Wei Wang  ¹, Yuan Liu  ¹, Wenhao Wang  ³, Zuyin Li  ⁴, Bin Yan  ¹, Xing Sun  ¹ （Affiliations 1 Department of General Surgery, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 2 Department of Vascular Surgery, Intervention Center, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 3 Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 4 Department of Hepatobiliary Surgery, Peking University Organ Transplantation Institute, Peking University People\'s Hospital, Beijing, China.）

出处： Frontiers in cell and developmental biology 2021 Vol.9 P796729

关键词： breast cancer;hypoxia;immune infiltration;long noncoding RNA;nomogram;prognosis.

摘要： Background: Female breast cancer is currently the most frequently diagnosed cancer in the world. This study aimed to develop and validate a novel hypo ...

作者： Na Li  ¹, Mingming Ma  ², Mengyu Lai  ¹, Liping Gu  ¹, Mei Kang  ³, Zilong Wang  ⁴, Shengyin Jiao  ⁴, Kang Dang  ⁴, Junxiao Deng  ⁴, Xiaowei Ding  ⁴, Qin Zhen  ¹, Aifang Zhang  ¹, Tingting Shen  ¹, Zhi Zheng  ², Yufan Wang  ¹, Yongde Peng  ¹ （Affiliations 1 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. 2 Department of Ophthalmology, Shanghai General Hospital, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai, China. 3 Clinical Research Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China. 4 VoxelCloud, Shanghai, China.）

出处： Journal of diabetes 2021

关键词： deep learning algorithm;diabetic retinopathy;referable DR;retinal fundus images.

摘要： Background: The aim of our research was to prospectively explore the clinical value of a deep learning algorithm (DLA) to detect referable diabetic re ...

作者： Shumei Li  ¹, Xiaohui Wei  ², Li Mao  ³, Xuejiao Wang  ², Jiao Huang  ⁴, Lei Yang  ⁴, Weiping Dong  ², Yuhang Ma  ², Xiaoying Ding  ², Yongde Peng  ⁴ （Affiliations 1 Department of Endocrinology and Metabolism, Shanghai General Hospital of Nanjing Medical University, Shanghai, China; Department of Endocrinology and Metabolism, Shanghai Fourth People\'s Hospital, School of Medicine, Tongji University, Shanghai, China. 2 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Cardiology, Shanghai Fourth People\'s Hospital, School of Medicine, Tongji University, Shanghai, China. 4 Department of Endocrinology and Metabolism, Shanghai General Hospital of Nanjing Medical University, Shanghai, China.）

出处： Annals of palliative medicine 2021 Vol.10 No.11 P11939-11949

关键词： Diabetes mellitus;Shanghai Songjiang district;metabolic disorder syndrome;pre-diabetes.

摘要： Background: The prevalence of diabetes in China has increased by nearly 18 times from 0.67% in 1980 to 12.8% in 2020. The incidence has occurred with ...

作者： Yunchen Luo  ¹, Zhijian Zhang  ¹, Liping Xiang  ², Bing Zhou  ², Xuejiao Wang  ¹, Yi Lin  ¹, Xiaoying Ding  ¹, Fang Liu  ¹, Yan Lu  ², Yongde Peng  ¹ （Affiliations 1 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.）

出处： Frontiers in endocrinology 2021 Vol.12 P780617

关键词： N6-methyladenosine;RNA methylation;fructose;lipid metabolism;non-alcoholic fatty liver disease.

摘要： Improvements in living standards have led to non-alcoholic fatty liver disease (NAFLD), one of the most common chronic liver diseases worldwide. Recen ...

作者： Zhi-Wen Luo  ¹, Ya-Ying Sun  ¹, Jin-Rong Lin  ¹, Bei-Jie Qi  ¹, Ji-Wu Chen  ² （Affiliations 1 Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China. 2 Department of Sports Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.）

出处： World journal of stem cells 2021 Vol.13 No.11 P1762-1782

关键词： C2C12 myoblast;Differentiation;Exosomes;Inflammation;Macrophage polarization;Proliferation.

摘要： Background: Acute muscle injuries are one of the most common injuries in sports. Severely injured muscles are prone to re-injury due to fibrotic scar ...

作者： Jia-Shuo Chao¹;Qi Zhu¹;De-Sheng Chen¹;Gui-Ming Chen¹;Xue-Qian Xie²;Ai-Qun Liu²;Sen-Lin Zhao³;Hong-Cheng Sun¹CA1 （1 Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; 2 Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China; 3 Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China）

出处： Hepatobiliary & Pancreatic Diseases International 2021

关键词： Hepatectomy;Hepatocellular carcinoma;Magnetic resonance imaging;Preoperative imaging;Resection.

摘要： Background : The optimal width of resection margin (RM) for hepatocellular carcinoma (HCC) remains controversial. This study aimed to investigate the ...

作者： Wang T;Dong L;Sun J;Shao J;Zhang J;Chen S;Wang C;Wu G;Wang X （Affiliations 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People\'s Republic of China. 2 Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People\'s Republic of China. 3 Department of Pathology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People\'s Republic of China. 4 Department of Urology, Shaoxing People\'s Hospital, Shaoxing, Zhejiang, People\'s Republic of China.）

出处： Cancer Management and Research 2021 Vol.13 P9095-9106

关键词： prostate cancer;microrna;biopsy;active surveillance;gleason upgrading

摘要： Background: The Gleason grading system is a major tool used for prediction of prostate cancer (PCa) behavior. Because of heterogeneity and sampling er ...

作者： Lin Chen  ¹, Shuai Yan  ¹, Ming Yang  ¹, Fudong Yu  ², Jingjing Wang  ³, Xiaoxin Wang  ³, Huanbai Xu  ¹, Jianxia Shi  ¹, Ling Pan  ¹, Yuexi Zeng  ¹, Siyu Li  ¹, Li Li  ¹, Li You  ¹, Yongde Peng  ¹ （Affiliations 1 Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200080, China. 2 Basic Reproduction Laboratory, Shanghai Institute of Planned Parenthood Research, Fudan University Shanghai 200032, China. 3 Shanghai Key Laboratory for Pancreatic Diseases, Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai 200080, China.）

出处： American journal of translational research 2021 Vol.13 No.11 P12601-12613

关键词： 16S ribosomal RNA;Gut microbiota;bone turnover marker;postmenopausal women.

摘要： Objective: The association of the gut microbiome with bone turnover markers (BTMs) in postmenopausal women is poorly understood. Methods: Fecal sample ...

作者： Yongang Li  ¹, Zongshan Li  ², Jiachen Gu  ³, Xiaomin Xu  ⁴, Huimin Chen  ⁴, Yaxing Gui  ⁵ （Affiliations 1 Department of Neurology, The First People\' Hospital of Wenling, Wenling, China. 2 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 3 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. 4 Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 5 Department of Neurology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. Electronic address: YaxingGui@shsmu.edu.cn.）

出处： Neuroscience letters 2021 P136414

关键词： Exosome;Parkinson’s disease;Wnt5a;neuronal inflammation.

摘要： Our previous investigation shown Wnt signal pathway was significantly activated during DA neuron differentiation of epiblast-derived stem cells. In th ...

作者： Jiali Zhu  ¹, Jinbao Li, Chun-Shiang Chung, Joanne L Lomas-Neira, Alfred Ayala （Affiliation 1 Department of Anesthesiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China Division of Surgical Research, Department of Surgery, Rhode Island Hospital & the Alpert School of Medicine at Brown University, Providence, RI 02830, USA.）

出处： Shock (Augusta, Ga.) 2021

摘要： Introduction: Severe hemorrhage (Hem) has been shown to be causal for the development of extra-pulmonary/indirect acute respiratory distress syndrome ...