上海交通大学附属第一人民医院肿瘤科是上海市三甲综合医院中最早设立的肿瘤专科，是医院“十二五”期间重点发展的学科之一。2009年，医院整合肿瘤相关学科资源，成立了肿瘤中心，学科带头人黄倩教授，中心主任王理伟教授，肿瘤中心副主任王红霞（兼肿瘤科副主任[主持，南]）、刘勇副主任医师，北部执行主任李琦主任医... [详细]
作者： Chen Dong, Wenzhi Tu, Mingyuan He, Jiamei Fu, Alisa Kobayashi, Teruaki Konishi, Chunlin Shao （Affiliations 1 Institute of Radiation Medicine, Fudan University, Shanghai 200032, China. 2 The Comprehensive Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. 3 Department of Accelerator and Medical Physics, National Institute of Radiological Sciences. 4 Department of Single Cell Radiation Biology Group, Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, Inage, Chiba 263-8555, Japan.）
出处： Radiation research 2020 Vol.193 No.1 P63-72
摘要： It is well known that mitochondria and the endoplasmic reticulum (ER) play important roles in radiation response, but their functions in radiation-ind ...
作者： Minghui Zhao, Yiwei Wang, Yucui Zhao, Sijia He, Ruyi Zhao, Yanwei Song, Jin Cheng, Yanping Gong, Jianzhu Xie, Yulan Wang, Binjie Hu, Ling Tian, Qian Huang （Affiliations 1 Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. 2 Shanghai Key Laboratory for Pancreatic Diseases, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China. 3 Department of Central Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.）
出处： Aging 2020 Vol.12
关键词： DNA damage response;caspase-3;non-small cell lung cancer;radiotherapy;tumor repopulation.
摘要： Radiotherapy is an effective treatment for non-small cell lung cancer (NSCLC). However, irradiated, dying tumor cells generate potent growth stimulato ...
作者： Yanli Li, Rui Yang, Limo Chen, Sufang Wu （Affiliations 1 Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, PR China. 2 Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.）
出处： Future oncology (London, England) 2020
关键词： CD38;biomarker;cancer immunotherapy;immune checkpoint therapy;immunomodulation;tumor microenvironment.
摘要： CD38 is a transmembrane glycoprotein that is widely expressed in a variety of human tissues and cells, especially those in the immune system. CD38 pro ...
作者： Xuguang Yang, Yun Lu, Junjie Hang, Junfeng Zhang, Tiening Zhang, Yanmiao Huo, Jun Liu, Songtao Lai, Dawei Luo, Liwei Wang, Rong Hua, Yuli Lin （Affiliations 1 The Comprehensive Cancer Center, Department of Oncology, State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiaotong University. 2 Longhua Hospital Shanghai University of Traditional Chinese Medicine. 3 Department of Oncology, Changzhou No.2 People\'s Hospital, Nanjing Medical University. 4 Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University. 5 radiation department, Shanghai General Hospital, Shanghai Jiaotong University. 6 Oncology Center, Shanghai General Hospital, Shanghai Jiaotong University. 7 Department of Radiation Oncology, Shanghai Cancer Center, Shanghai Medical College, Fudan University. 8 Department of Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University. 9 Department of Biliary-Pancreatic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University. 10 Department of Immunology, School of Basic Medical Sciences, Fudan University yulilin@fudan.edu.cn.）
出处： Cancer immunology research 2020
摘要： The mechanisms responsible for radioresistance in pancreatic cancer have yet to be elucidated and the suppressive tumor immune microenvironment must b ...
作者： Zhong Wan, Tingyu Liu, Liang Wang, Rong Wang, Hai Zhang （Affiliations 1 Department of Pharmacy, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China. 2 Urologic Medical Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 3 State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China. 4 Department of Pharmacy, Shanghai 9th People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China.）
出处： Aging 2020 Vol.12 No.18 P18192-18208
关键词： MAPK14;hepatocellular carcinoma;miR-216a-3p;sorafenib resistance.
摘要： We investigated MAPK14-dependent resistance to sorafenib in hepatocellular carcinoma (HCC). Bioinformatics analysis and dual luciferase reporter assay ...
作者： Liu, Y.;Lu, L.-L.;Wen, D.;Liu, D.-L.;Dong, L.-L.;Gao, D.-M.;Bian, X.-Y.;Zhou, J.;Fan, J.;Wu, W.-Z. （a Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, 180 Fenglin Road, Shanghai, 200032, China; b Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People\'s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; c Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China; d Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China; e Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai, 200032, China）
出处： Journal of Hematology and Oncology 2020 Vol.13 No.1
摘要： The original article \'(1)\' contains an error in Fig. 3c and Fig. 3g whereby the image of group WT and NC in HCCLM3 cell lines were repeated. The cor ...
作者： Tao Wang;Quan Zhou;Han Zeng;Hongyu Zhang;Zhaopei Liu;Jialiang Shao;Zewei Wang;Ying Xiong;Jiajun Wang;Qi Bai;Yu Xia;Yiwei Wang;Li Liu;Yu Zhu;Le Xu;Bo Dai;Jianming Guo;Yuan Chang;Xiang Wang;Jiejie Xu （Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China. Department of Urology, Shanghai Ninth People\'s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. changyuan0802@163.com. Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. drseanwang@163.com. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. jjxufdu@fudan.edu.cn.）
出处： Cancer immunology, immunotherapy 2020
关键词： CCR8+Treg;Immune evasion;Muscle-invasive bladder cancer;Prognosis;Therapeutic target
摘要： Regulatory T cells (Tregs) play a major role in the development of an immunosuppressive tumor microenvironment. Systemic Treg depletion is not favored ...
作者： Fan, Xing-Wen (AUTHOR);Yang, Yu (AUTHOR);Wang, Hong-Bing (AUTHOR);Xu, Yin (AUTHOR);Kang, Mei (AUTHOR);Xie, Li-Yi (AUTHOR);Li, Ling (AUTHOR);Fang, Wen-Tao (AUTHOR);Zhao, Kuai-Le (AUTHOR);Chen, Hai-Quan (AUTHOR);Xiang, Jia-Qing (AUTHOR);Ung, Yee C. (AUTHOR);Wong, C. Shun (AUTHOR);Jiang, Guo-Liang (AUTHOR);Wu, Kai-Liang (AUTHOR)( wukailiang@aliyun.com) （1 Department of Radiation Oncology, Shanghai Cancer Center, Fudan University, Shanghai, China 2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China 3 Clinical Research Center, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China 4 Department of Thoracic Surgery, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, China 5 Department of Thoracic Surgery, Shanghai Cancer Center, Fudan University, Shanghai, China 6 Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada 7 Department of Radiation Oncology, Shanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai Proton and Heavy Ion Center, Shanghai, China）
出处： International Journal of Radiation Oncology, Biology, Physics 2020 Vol.107 No.1 P98-105
关键词： etoposide/cisplatin;intensity-modulated radiotherapy;thymic carcinoma;thymoma
摘要： Purpose: This prospective phase 2 study evaluated the efficacy and safety of intensity modulated radiation therapy plus etoposide/cisplatin (EP) for p ...
作者： Baoying Hu;Zewei Wang;Han Zeng;Yangyang Qi;Yifan Chen;Tao Wang;Jiajun Wang;Yuan Chang;Qi Bai;Yu Xia;Yiwei Wang;Li Liu;Yu Zhu;Bo Dai;Jianming Guo;Le Xu;Weijuan Zhang;Jiejie Xu （Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University. Department of Urology, Zhongshan Hospital of Fudan University. Department of Immunology, Shanghai Medical College of Fudan University. Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University. Department of Urology, Zhongshan Hospital, Fudan University. Department of Urology, Fudan University Shanghai Cancer Center. Department of Urology, Shanghai Ninth People\'s Hospital, Shanghai Jiao Tong University School of Medicine. Urology, Fudan University Shanghai Cancer Center. Department of Urology, Zhongshan Hospital Fudan University. Department of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University jjxufdu@fudan.edu.cn.）
出处： Cancer research 2020
摘要： Tumor-associated macrophages (TAMs) play an indispensable role in the modulation of the cancer immune microenvironment. Despite the fact that TAMs may ...
作者： Runzhi Huang, Jiaqi Zhang, Mingxiao Li, Penghui Yan, Huabin Yin, Suna Zhai, Xiaolong Zhu, Peng Hu, Jiaxin Zhang, Ling Huang, Man Li, Zehui Sun, Tong Meng, Daoke Yang, Zongqiang Huang （Affiliations 1 Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, 1 East Jianshe Road, Zhengzhou, China. 2 Division of Spine, Department of Orthopedics, Tongji Hospital Affiliated to Tongji University School of Medicine, 389 Xincun Road, Shanghai, China. 3 Tongji University School of Medicine, 1239 Siping Road, Shanghai 200092, China. 4 Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, 100 Haining Road, Shanghai, China. 5 Department of Radiotherpy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. 6 Tongji University Cancer Center, Shanghai Tenth People\'s Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.）
出处： PPAR research 2020 Vol.2020 P6527564
摘要： Peroxisome proliferator-activated receptors (PPARs) are members of nuclear transcription factors. The functions of the PPAR family (PPARA, PPARD, and ...
