作者： Ting Wang  ¹ , Wenjun Pan, Hang Zheng, Hongping Zheng, Zhejun Wang, Jia Li, Chuxia Deng, Jun Yan （Affiliation 1 Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, P.R. China. Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer, Guangzhou, Guangdong, 510515, P.R. China. Department of Oncology, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, P.R. China. Accurate International Biotechnology Limited Company, Guangzhou, Guangdong, 510515, P.R. China. Guangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province 519000, P.R. China. Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, 200080, P.R. China. Cancer Center, Faculty of Health Sciences, University of Macau, Macau, SAR of P.R. China.）

出处： Diseases of the colon and rectum 2021 Vol.64 No.7 P833-850

关键词： 1ST-LINE TREATMENT;FLUOROURACIL;OXALIPLATIN;MULTICENTER;LEUCOVORIN;IRINOTECAN;BIOBANK;TRIAL

摘要： Background: Patient-derived tumor organoid culture has emerged as a preclinical model that has the potential to predict individual drug response. Howe ...

作者： Tengteng Zhu  ¹ , Qiang Li  ² , Liming Xu  ³ , Qi Zhang  ¹ , Wenwen Lv  ¹ , Herbert Yu  ⁴ , Tienan Feng  ⁵ , Biyun Qian  ⁶ （Affiliations 1 Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. tienan@sjtu.edu.cn qianbiyun@sjtu.edu.cn. 2 Public Health School, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. 3 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. 4 A Cancer Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA. 5 Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. tienan@sjtu.edu.cn qianbiyun@sjtu.edu.cn and Second Affiliated hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan 610051, China. 6 Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. tienan@sjtu.edu.cn qianbiyun@sjtu.edu.cn and Shanghai Clinical Research Promotion and Development Center, Shanghai Shenkang Hospital Development Center, Shanghai 200041, People\'s Republic of China.）

出处： Food & function 2021

关键词： ADMINISTERED 4 TIMES;PHASE-I TRIAL;ALCOHOL NSC 641066;PERILLYL ALCOHOL;ANTICANCER ACTIVITIES;CELL INVASION;ESSENTIAL OIL;CANCER;INHIBITION;SURVIVAL

摘要： Globally, lung cancer ranks as the most lethal malignant neoplasm. d-Limonene, a plant extract enriched with essential oils, has been reported to exer ...

作者： Feng-Hua Wang  ¹ , Xiao-Li Wei  ¹ , Jifeng Feng  ² , Qi Li  ³ , Nong Xu  ⁴ , Xi-Chun Hu  ⁵ , Wangjun Liao  ⁶ , Yi Jiang  ⁷ , Xiao-Yan Lin  ⁸ , Qing-Yuan Zhang  ⁹ , Xiang-Lin Yuan  ¹⁰ , Hai-Xin Huang  ¹¹ , Ye Chen  ¹² , Guang-Hai Dai  ¹³ , Jian-Hua Shi  ¹⁴ , Lin Shen  ¹⁵ , Shu-Jun Yang  ¹⁶ , Yong-Qian Shu  ¹⁷ , Yun-Peng Liu  ¹⁸ , Weifeng Wang  ¹⁹ , Hai Wu  ²⁰ , Hui Feng  ²⁰ , Sheng Yao  ²⁰ , Rui-Hua Xu  ^{1   21} （Affiliations 1 Department of Medical Oncology of Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University, Guangzhou, China. 2 Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China. 3 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 4 The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. 5 Fudan University Shanghai Cancer Center, Shanghai, China. 6 Cancer Center of Nan Fang Hospital, Guangzhou, China. 7 The Affiliated Cancer Hospital of Shantou University, Shantou, China. 8 Union Hospital of Fujian Medical University, Fuzhou, China. 9 The affiliated Cancer Hospital of Harbin Medical University, Harbin, China. 10 Wuhan Tongji Hospital, Wuhan, China. 11 Liuzhou Worker\'s Hospital, Liuzhou, China. 12 Cancer Center of West China Hospital of Sichuan University, Chengdu, China. 13 Beijing 301 Hospital, Beijing, China. 14 Linyi Cancer Hospital, Linyi, China. 15 Beijing Cancer Hospital & Institute, Beijing, China. 16 Henan Cancer Hospital, Zhengzhou, China. 17 Jiangsu Provincial Hospital, Nanjing, China. 18 The First Hospital of China Medical University, Shenyang, China. 19 OrigiMed, Shanghai, China. 20 Shanghai Junshi Biosciences Co, Ltd, Shanghai, China. 21 Research Unit of Precision Diagnosis and Treatment for Gastrointestinal Cancer, Chinese Academy of Medical Sciences, Guangzhou, China.）

出处： Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2021 Vol.39 No.7 PJCO2002712

摘要： Purpose: As yet, no checkpoint inhibitor has been approved to treat nasopharyngeal carcinoma (NPC). This study was aimed to evaluate the antitumor act ...

作者： Xue-Ping Li  ^{1   2} , Xin Huang  ^{2   3} , Yan-Mei Qin  ⁴ , Guo-Yan Wu  ⁵ , Cheng-Cai Liang  ^{2   6} , Yu-Jun Dai  ^{1   2} , Wei-Na Zhang  ⁷ （Affiliations 1 Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. 2 State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. 3 Department of Pancreatobiliary Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China. 4 Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China. 5 Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Department of Gastric Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China. 7 Department of Hematology, Guangzhou Women and Children\'s Medical Center, Guangzhou Medical University, Guangzhou, China.）

出处： Clinical and translational medicine 2021 Vol.11 No.2 Pe345

作者： Ning Li  ¹ , Hualei Bu  ² , Jihong Liu  ³ , Jianqing Zhu  ⁴ , Qi Zhou  ⁵ , Li Wang  ⁶ , Rutie Yin  ⁷ , Xiaohua Wu  ⁸ , Shuzhong Yao  ⁹ , Kangsheng Gu  ¹⁰ , Hui Zhang  ¹¹ , Guiling Li  ¹² , Hongming Pan  ¹³ , Qiang Wu  ¹⁴ , Ruifang An  ¹⁵ , Xinfeng Yang  ¹⁶ , Ya Ping Zhu  ¹⁷ , Xiaoping Wan  ¹⁸ , Wei Duan  ¹⁹ , Jianping Xiong  ²⁰ , Hongyan Guo  ²¹ , Ge Lou  ²² , Jing Wang  ²³ , Wen Jing Hu  ²⁴ , Xin Zhang  ²⁵ , Yuanguang Meng  ²⁶ , Ben Zhang  ²⁷ , Yuting Wang  ²⁷ , Quan Ren Wang  ²⁸ , Lingying Wu  ²⁹ （Affiliations 1 Department of Gynecologic Oncology, National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. 2 Qilu Hospital of Shandong University. 3 Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center and State Key Laboratory of Oncology in South China. 4 Department of Gynecological Oncology, Zhejiang Cancer Hospital. 5 Chongqing Office for Cancer Control and Research, Chongqing Cancer Hospital. 6 Cancer Hospital of Zhengzhou University (Henan Cancer Hospital). 7 Obstetric and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of Education. 8 Department of Gynaecological Oncology, Fudan University Shanghai Cancer Center. 9 Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-sen University. 10 Department of Oncology, The First Affiliated Hospital of Anhui Medical College. 11 Fourth Hospital of Hebei Medical University. 12 Cancer Center, Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. 13 Department of Medical Oncology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University. 14 Jiangsu Cancer Hospital. 15 First Affiliated Hospital of Xi\'an Jiaotong University. 16 Jiangxi Provincial Cancer Hospital. 17 Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. 18 Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tong Ji University School of Medicine. 19 Beijing Obstetrics and Gynecology Hospital, Capital Medical University. 20 Nanchang University First Affiliated Hospital. 21 Obstetrics & Gynecology, Peking University Third Hospital. 22 First Affiliated Hospital of Zhengzhou University. 23 The Affiliated Cancer Hospital of XiangYa School of Medicine, Central South University, The Affiliated Cancer Hospital of XiangYa School of Medicine, Central South University. 24 Oncology Department, The comprehensive cancer center of Drum Tower Hospital，The affiliated Hospital of Nanjing University Medical School. 25 Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute. 26 Chinese PLA General Hospital. 27 Jiangsu Hengrui Medicine Co., Ltd. 28 Clinical department oncology, Jiangsu Hengrui Medicine Co., Ltd. 29 Department of Gynecologic Oncology, Cancer Hospital Chinese Academy of Medical Sciences, Peking Union Medical College wulingying@csco.org.cn.）

出处： Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Vol.27 No.9 P2452-2458

关键词： OLAPARIB MONOTHERAPY;PARP INHIBITOR;RUCAPARIB;SAFETY;LINES

摘要： Purpose: Fluzoparib (PARP inhibitor) showed promising anti-tumor activity for advanced ovarian cancer in a phase 1 study. This study aimed to assess t ...

作者： Hongcheng Zhu  ¹ , Eleonor Rivin Del Campo  ² , Jinjun Ye  ³ , Charles B Simone 2nd  ⁴ , Zhengfei Zhu  ¹ , Weixin Zhao  ¹ , Arya Amini  ⁵ , Jialiang Zhou  ⁶ , Chaoyang Wu  ⁷ , Huarong Tang  ⁷ , Min Fan  ¹ , Ling Li  ¹ , Qin Lin  ⁸ , Yi Xia  ⁹ , Yunhai Li  ⁹ , Jiancheng Li  ¹⁰ , Miao Mo  ¹¹ , Huixun Jia  ¹² , Saiquan Lu  ¹ , Juanqi Wang  ¹ , Yongzhan Nie  ¹³ , Junqiang Chen  ¹⁰ , Shixiu Wu  ¹⁴ , Masatsugu Hamaji  ¹⁵ , Waqar Haque  ¹⁶ , Bae Kwon Jeong  ¹⁷ , Ravi Shridhar  ¹⁸ , Zhen Zhang  ¹ , Yun Chen  ¹ , Kuaile Zhao  ¹⁹ （Affiliations 1 Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 2 Department of Radiation Oncology, Tenon University Hospital, Hôpitaux Universitaires Est Parisien, Sorbonne University, Paris, France. 3 Department of Radiation Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China. 4 New York Proton Center and Memorial Sloan Kettering Cancer Center, New York, NY, USA. 5 Department of Radiation Oncology, City of Hope Medical Center, Duarte, CA, USA. 6 Department of Radiation Oncology, Affiliated Hospital of Jiangnan University, Wuxi, China. 7 Department of Radiation Oncology, Zhenjiang First People\'s Hospital Affiliated to Jiangsu University, Zhenjiang, China. 8 Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, China. 9 Department of Radiation Oncology, Fudan University Shanghai Cancer Center Minhang Branch Hospital, Shanghai, China. 10 Department of Radiation Oncology, Fujian Cancer Hospital, Fujian Medical University Cancer Hospital, Fuzhou, China. 11 Department of Cancer Prevention and Statistics, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 12 Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. 13 State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi\'an, China. 14 Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen, China. 15 Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan. 16 Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA. 17 Department of Radiation Oncology, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea. 18 Department of Radiation Oncology, Florida Hospital Orlando, Orlando, FL, USA. 19 Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: kuaile_z@sina.com.）

出处： International journal of radiation oncology, biology, physics 2021 Vol.110 No.5 P1396-1406

关键词： Esophageal squamous cell carcinoma;definitive chemoradiotherapy;elective nodal irradiation;involved-field irradiation;lymph node failure rate.

摘要： Objective: To evaluate the feasibility and efficacy of involved-field irradiation in definitive chemoradiotherapy for loco-regional esophageal squamou ...

作者： （Affiliations 1 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Early Drug Development Center, Peking University Cancer Hospital & Institute, No. 52, Fucheng Road, Haidian District, Beijing, 100142, China. 2 Fudan University Shanghai Cancer Center, 270 Dong \'an Road, Xuhui District, Shanghai, 200032, China. 3 The First Affiliated Hospital of Xinxiang Medical School, 88 Jiankang Road, Weihui, 453100, China. 4 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology/Early Drug Development Center, Peking University Cancer Hospital & Institute, No. 52, Fucheng Road, Haidian District, Beijing, 100142, China. 5 The Fifth Affiliated Hospital Sun Yat-Sen University, 52 Meihua East Road, Xiangzhou District, Zhuhai, 519000, China. 6 Harbin Medical University Cancer Hospital, 150 Haping Road, Nangang District, Harbin, 150081, China. 7 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), The Department of Lymphoma, Peking University Cancer Hospital & Institute, No. 52 Fucheng Road, Haidian District, Beijing, 100142, China. 8 Thoracic Medicine Department I, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Yuelu District, Changsha, 410013, China. 9 The Second General Hospital of Neijiang City, 224 Xinjiang Road, Dongxing District, Neijiang, 641100, China. 10 The First Affiliated Hospital of Zhengzhou University, 1 Jianshe East Road, Zhengzhou, 450052, China. 11 Tianjin Medical University Cancer Institute & Hospital, Huanhu West Road, Tiyuan North, Hexi District, Tianjin, 300060, China. 12 The First Affiliated Hospital of Nanchang University, 17 Yongwai Main Street, Donghu District, Nanchang, 330006, China. 13 Fujian Provincial Cancer Hospital, 420 Fuma Road, Jin\'an District, Fuzhou, 350014, China. 14 Shanghai General Hospital, 85 Wujin Road, Hongkou District, Shanghai, 200080, China. 15 Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, No.1277 Jiefang Avenue, Wuhan, 430022, China. 16 Department of Interventional Radiology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Yuelu District, Changsha, 410013, China. 17 Department of Gastroenterology and Urology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Yuelu District, Changsha, 410013, China. 18 Beijing Friendship Hospital, Capital Medical University, 95 Yongan Road, Xicheng District, Beijing, 100050, China. 19 Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Yuelu District, Changsha, 410013, China. 20 Zhejiang Provincial People\'s Hospital, People\'s Hospital of Hangzhou Medical College, No.158 Shangtang Road, Xiacheng District, Hangzhou, 310014, China. 21 Zhongshan Hospital, Fudan University, No.180 Fenglin Road, Xuhui District, Shanghai, 200032, China. 22 The Fifth Medical Center of PLA General Hospital, No.8 Fengtai East Street, Fengtai District, Beijing, 100071, China. 23 Tongji Hospital, Tongji Medical College Huazhong University of Science &Technology, No. 1095 Jiefang Avenue, Wuhan, 430030, China. 24 Guizhou Cancer Hospital, No. 1 Beijing West Road, Yunyan District, Guiyang, 550004, China. 25 Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100083, China. 26 Department of Oncological Radiotherapy, Peking University Cancer Hospital & Institute, No. 52, Fucheng Road, Haidian District, Beijing, 100142, China. 27 The First Affiliated Hospital of Bengbu Medical School, No 287 Changhuai Road, Longzihu District, Bengbu, 233000, China. 28 Beijing Youan Hospital, Capital Medical University, 8 West Toutiao, Youanmenwai, Fengtai District, Beijing, 100069, China. 29 Nanfang Hospital, The First Affiliated Hospital of Southern Medical School, 1838 Guangzhou Avenue North, Baiyun District, Guangzhou, 510515, China. 30 Institute of Hematology & Blood Diseases Hospital, No. 288 Nanjing Road, Heping District, Tianjin, 300051, China. 31 Jiangsu Province Hospital, No. 300 Guangzhou Road, Gulou District, Nanjing, 210005, China. 32 Shanghai General Hospital, No. 100 Haining Road, Hongkou District, Shanghai, 200080, China. 33 Guangzhou Gloria Biosciences Co., Ltd., Yuhua Road, Shunyi District, Beijing, 101318, China. 34 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology/Early Drug Development Center, Peking University Cancer Hospital & Institute, No. 52, Fucheng Road, Haidian District, Beijing, 100142, China. Electronic address: linshenpku@163.com.）

出处： European journal of cancer (Oxford, England : 1990) 2021 Vol.148 P1-13

关键词： Efficacy;Phase Ia/Ib study;Programmed death-1 monoclonal antibody;Safety;Solid tumors.

摘要： Background: GLS-010, a novel engineered fully human immunoglobin G4 monoclonal antibody, can specially block the PD-1/PD-L1/2 axis and reactivate the ...

作者： （1 1 Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA; 2 2 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy; 3 3 Johannes Gutenberg University, Institute of Pharmaceutical and Biomedical Sciences, Department of Pharmaceutical Biology, Mainz, Germany; 4 4 Medical University of Graz, Division of Cardiology, Graz, Austria; 5 5 Pasteur institute of Iran, Department of Hepatitis and HIV, Tehran, Iran.; 6 6 Department of Molecular Signal Processing, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany; 7 7 Hebrew University of Jerusalem, Department of Biochemistry and Food Science, Rehovot, Israel; 8 8 Danish Cancer Society Research Center, RNA and Autophagy Group, Copenhagen, Denmark;1302 University of Copenhagen, Biotech Research and Innovation Centre, Copenhagen, Denmark; 9 10 University of Tromsø - The Arctic University of Norway, Department of Medical Biology, Tromsø, Norway; 10 11 Hospital Universitario de Canarias, Research Unit; CIBERNED and Universidad de La Laguna, ITB, Santa Cruz de Tenerife, Spain; 11 12 University of California, Davis, Division of Rheumatology, Allergy and Clinical Immunology, School of Medicine, Sacramento, CA, USA; 12 13 University of Toronto, Department of Biochemistry, Toronto, Ontario, Canada; 13 14 Medical University Innsbruck, Department of Medicine I, Innsbruck, Austria; 14 15 University of Calabria, Department of Pharmacy, Health and Nutritional Sciences, Arcavacata di Rende (CS), Italy; 15 16 National Institutes of Health, National Eye institute, Protein Structure and Function Section, Bethesda, MD, USA; 16 17 Ben-Gurion University of the Negev, Faculty of Health Sciences, Department of Clinical Biochemistry and Pharmacology, Beer-Sheva, Israel; 17 18 University of Alabama at Birmingham, Division of Nephrology and Birmingham VA Medical Center, Birmingham, AL, USA; 18 19 Inflammation Research Center, San Diego, CA, USA; 19 20 University of Palermo, Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Palermo, Italy; 20 21 Cell Death Research & Therapy (CDRT) Lab, Department of Cellular & Molecular Medicine, Center for Cancer Biology, VIB-KU Leuven, Leuven, Belgium; 21 22 Indian Institute of Technology, Ropar, India; 22 23 University of Dundee, School of Life Sciences, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, UK; 23 24 University of Texas Medical Branch, Department of Pathology, Galveston, TX, USA; 24 25 Colby College, Department of Biology, Waterville, ME, USA; 25 26 University of Maryland School of Medicine, Departments of Otorhinolaryngology Head & Neck Surgery, Ophthalmology and Visual Science, Baltimore, MD, USA; 26 27 Universidad Mayor, Center for Integrative Biology, and Geroscience Center for Brain Health and Metabolism, Santiago, Chile; 27 28 Lund University, Department of Experimental Medical Science, Cell Death, Lysosomes and Artificial Intelligence Group, Lund, Sweden; 28 29 Nihon University, College of Bioresource Sciences, Fujisawa, Kanagawa, Japan; 29 30 Koç University School of Medicine, Department of Molecular Biology and Genetics and KUTTAM Research Center for Translational Medicine, Istanbul, Turkey; 30 31 University of Crete, School of Medicine, Laboratory of Clinical Microbiology and Microbial Pathogenesis, Voutes, Heraklion, Crete, Greece; Foundation for Research and Technology, Institute of Molecular Biology and Biotechnology (IMBB), Heraklion, Crete, Greece;32 University of Crete, School of Medicine, Laboratory of Clinical Microbiology and Microbial Pathogenesis, Voutes, Heraklion, Crete, Greece; 31 33 The Institute of Cancer Research, Cancer Therapeutics Unit, Sutton, UK; 32 34 Pharmaceutical Sciences Department, College of Pharmacy, Gulf Medical University, Ajman, United Arab Emirates; 33 35 University of Sydney, Department of Pathology and Bosch Institute, Sydney, NSW, Australia; 34 36 Insight Institute of Neurosurgery & Neuroscience, Department of Research, Flint, MI, USA; 35 37 McGill University, Departments of Medicine and Oncology and Segal Cancer Centre, Montreal, Quebec, Canada; 36 38 Technical University Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Biotechnology Center (BIOTEC), Department of Cellular Biochemistry, Dresden, Germany; 37 39 Universidad de Sevilla, Departamento de Psicología Experimental, Facultad de Psicología, Sevilla, Spain; 38 40 Sapienza University of Rome, Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Rome, Italy; 39 41 The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 40 42 University of Rajshahi, Department of Pharmacy, Rajshahi, Bangladesh; 41 2308 Department of Biological Sciences and Biotechnology, Faculty of Sciences, Islamic University of Gaza, Gaza 108, Palestine; 42 44 Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada; 43 45 University of Barcelona, Faculty of Pharmacy, Department of Biochemistry and Physiology, Barcelona, Spain;46 Metabolism and Cancer Laboratory, Molecular Mechanisms and Experimental Therapy in Oncology Program (Oncobell), Institut d\'Investigació Biomèdica de Bellvitge - IDIBELL, L\'Hospitalet de Llobregat, Barcelona, Spain;47 The Francis Crick Institute, Molecular Cell Biology of Autophagy, London, UK; 44 48 Cleveland Clinic, Department of Cancer Biology, Cleveland, OH, USA; 45 49 University of the Basque Country, Instituto Biofisika (UPV/EHU, CSIC), and Department of Biochemistry and Molecular Biology, Leioa, Spain; 46 50 Instituto de Investigaciones en Ingeniería Genética y Biología Molecular “Dr. Héctor N. Torres”, Laboratorio de señalización y mecanismos adaptativos en Tripanosomátidos, Buenos Aires, Argentina; Universidad de Buenos Aires, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina; 47 51 Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA; 48 52 The Wistar Institute, Philadelphia, PA, USA; 49 53 Buenos Aires University, Biochemistry and Pharmacy School, Deparment of Microbiology Immunology Biotechnology and Genetic, IDEHU, CABA, Argentina; 50 1893 Universidade do Porto, i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal; IPATIMUP - Institute of Molecular Pathology and Immunology of the University of Porto, Cancer Drug Resistance Group, Porto, Portugal; FFUP - Faculty of Pharmacy of the University of Porto, Department of Biological Sciences, Porto, Portugal; 51 54 Université Côte d\'Azur, INSERM, CNRS, IPMC, team labeled (Laboratory of Excellence (LABEX) Distalz), Valbonne, France; 52 43 Islamic University of Gaza, Department of Medical Laboratory Sciences, Faculty of Health Sciences, Gaza, Palestine; 53 55 University of Pavia, Department of Drug Sciences, Pharmacology Unit, Pavia, Italy; 54 56 University of Camerino, School of Biosciences and Veterinary Medicine, Camerino, Italy; 55 57 University of Porto, Faculty of Pharmacy, UCIBIO, REQUIMTE, Porto, Portugal; 56 58 Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, Italy; 57 59 Ohio State University, Department of Microbial Infection and Immunity, and the Infectious Disease Research Institute, Columbus, OH, USA; 58 60 Save as Ravi Manjithaya; 59 61 University of California, San Francisco, San Francisco, CA, USA; 60 62 Aarhus University, Department of Molecular Biology and Genetics, Aarhus C, Denmark; 61 63 Departments of Pharmacology and Toxicology, and Neurology, The University of Alabama at Birmingham, Birmingham, AL, USA; 62 64 Federal University of São Paulo, Department of Medicine, Nephrology Division, Laboratory of Clinical and Experimental Immunology, São Paulo, SP, Brazil;65 Universidade Nove de Julho (UNINOVE), Faculty of Pharmacy, São Paulo, SP, Brazil; 63 66 Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles CA, USA; 64 67 University of Bologna, Department of Pharmacy and Biotechnology, Bologna, Italy; 65 68 City of Hope Comprehensive Cancer Center, Beckman Research Institute, Department of Diabetes Complications and Metabolism, Duarte, CA, USA; 66 69 University of Tennessee, Department of Chemical and Biomolecular Engineering, Knoxville, TN, USA; 67 70 Northeast Ohio Medical university, Department of Anatomy & Neurobiology, Rootstown, OH, USA; 68 71 iNOVA4Health Chronic Diseases Research Center (CEDOC), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal; 69 72 Max Planck Institute for Biology of Ageing and CECAD, University of Cologne, Germany; 70 73 School of Biochemistry, Faculty of Life Sciences, University of Bristol, Bristol, UK; 71 74 University of Helsinki, Molecular and Integrative Biosciences Research Programme, Helsinki, Finland; 72 312 INSERM, U1231, Dijon, France; 73 76 University of Valencia, Faculty of Medicine, Department of Pharmacology, Valencia, Spain; CIBERehd (Centre for Networked Biomedical Research in Hepatic and Digestive Diseases), Valencia, Spain; 74 77 National Institute of Neuroscience, National Center of Neurology and Psychiatry, Department of Peripheral Nervous System Research, Kodaira, Tokyo, Japan; 75 78 Osaka University, Graduate School of Dentistry, Osaka, Japan; 76 79 Tokyo University of Pharmacy and Life Sciences, School of Life Sciences, Hachioji, Horinouchi, Tokyo, Japan; 77 80 Universidade Federal de Viçosa, Departamento de Biologia Vegetal, Viçosa, MG, Brazil; 78 81 The Jikei University School of Medicine, Division of Respiratory Disease, Departent of Internal Medicine, Tokyo, Japan; 79 82 Newcastle University, Biosciences Institute, Newcastle Upon Tyne, UK; 80 83 Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC) and CIBERFES, Madrid, Spain; 81 84 University of Seville, Faculty of Pharmacy, Department of Physiology, Seville, Spain; 82 85 Albert Einstein College of Medicine, Department of Medicine, Bronx, NY, USA; 83 86 Howard University College of Medicine, Department of Anatomy, Washington D.C., USA; 84 87 Tohoku University, Graduate School fo Life Sciences, Sendai, Miyagi, Japan; 85 88 University of Michigan, Life Sciences Institute, Ann Arbor, MI, USA; 86 89 Imperial College London, MRC Centre for Molecular Bacteriolgy and Infection, Department of Microbiology, London, UK; 87 90 Toulouse University, CNRS, UPS, Center for Integrative Biology (CBI), Research Center on Animal Cognition (CRCA), Toulouse, France; 88 91 Iowa State University, Department of Genetics, Development and Cell Biology, Roy J. Carver Co-Laboratory, Ames, IA, USA; 89 92 Universidad Nacional de Cordoba, Laboratorio de Oncohematología, Hospital Nacional de Clínicas, CONICET, Córdoba, Argentina; 90 93 York College/The City University of New York, Department of Biology, Jamaica, NY, USA; 91 94 Translational Genomics Group, Incliva Health Research Institute, Burjasot, Valencia, Spain; Interdisciplinary Research Structure for Biotechnology and Biomedicine (ERI BIOTECMED), University of Valencia, Burjasot, Valencia, Spain; 92 95 University of Palermo, Department of Biological, Chemical and and Pharmaceutical Sciences and Technologies, Palermo, Italy; 93 96 Albert Einstein College of Medicine, Department of Molecular Pharmacology, Bronx, NY, USA; 94 97 Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, 34956 Istanbul, Turkey; Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, 34956, Istanbul, Turkey; 95 98 Meir Medical Center, Translational Hemato-Oncology Laboratory, Kfar-Saba, Israel; Tel Aviv University, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv, Israel; 96 99 The Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Magdalenka, Poland; Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, Vienna, Austria; Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria; Department of Pharmacognosy, University of Vienna, Vienna, Austria; 97 100 University of Pittsburgh Medical Center, Department of Critical Care Medicine, Department of Pediatrics, Safar Center for Resuscitation Research and the Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA; 98 101 University of Nice, Mediterranean Center for Molecular Medicine, Inserm U1065, Nice, France; 99 102 Imperial College London, Faculty of Medicine, London, UK; 100 103 Departments of Pharmacology and Microbiology, University of Maryland School of Medicine, Baltimore, MD, USA; Stanford University School of Medicine Stanford, CA, USA; 101 104 University of Turin, Department of Clinical and Biological Sciences, Turin, Italy; 102 105 University of Milan, Department of Health Sciences, Milano, Italy; 103 106 Universidad de Santiago de Chile, Faculty of Chemistry and Biology, Department of Biology, Santiago, Chile; 104 107 Fondazione Istituto di Ricerca Pediatrica Città della Speranza, Neuroblastoma Laboratory, Padua, Italy; 105 615 CNC - Center for Neuroscience and Cell Biology, Coimbra, IIIUC - Instituto de Investigação Interdisciplinar, University of Coimbra, Coimbra, Portugal; 106 108 The Hebrew University of Jerusalem, Alexander Silberman Institute of Life Sciences, Department of Plant and Environmental Sciences, Edmond Safra Campus, Jerusalem, Israel; 107 109 Tulane Health Sciences Center, Department of Pathology and Laboratory Sciences, New Orleans, LA, USA; 108 110 Melbourne Dementia Research Centre, The Florey Institute of Neuroscience & Mental Health, The University of Melbourne, Parkville, VIC, Australia; 109 111 University of Arkansas for Medical Sciences, Department of Geriatrics, Little Rock, AR, USA; 110 112 University of Malta, Department of Physiology & Biochemistry, Msida, Malta; 111 113 Kogakuin University, Research Institute for Science and Technology, Hachioji, Tokyo, Japan; 112 114 Albert Einstein College of Medicine, Departments of Molecular Pharmacology and Biochemistry, Bronx, NY, USA; 113 115 Eastern Michigan University, Department of Chemistry, Ypsilanti, MI, USA; 114 116 Hanyang University, College of Pharmacy, Ansan, Gyeonggido, Korea; 115 117 Yonsei University College of Medicine, Severance Biomedical Science Institute, Seoul, Korea; 116 118 University of Massachusetts Medical School, Department of Molecular, Cell and Cancer Biology, Worcester, MA, USA; 117 119 Konkuk University, Department of Bioscience and Biotechnology, Seoul, Korea; 118 120 Ajou University, College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Suwon, Korea; 119 121 Seoul National University, Department of Biological Sciences, Seoul, South Korea; 120 122 University of Calabria, Department of Pharmacy, Health Science and Nutrition, Section of Preclinical and Translational Pharmacology, Cosenza, Italy; 121 123 Adam Mickiewicz University/Faculty of Biology, Institute of Experimental Biology, Department of General Botany, Poznan, Poland; 122 124 Iowa State University, Department of Genetics, Development, and Cell Biology, Ames, IA, USA; 123 125 Kunming University of Science and Technology, Medical School, Kunming, Yunnan, China; 124 126 National Jewish Health, Department of Academic Affairs, Denver, CO, USA; 125 127 University of Texas Health Science Center at San Antonio, Department of Cell Systems and Anatomy, San Antonio, TX, USA; 126 128 Jadavpur University, Department of Mathematics, Centre for Mathematical Biology and Ecology, Kolkata, India; 127 129 Karolinska Institute, Department of Cell and Molecular Biology, Stockholm, Sweden; 128 130 University of Genoa, Department of Earth, Environment and Life Sciences, Genoa, Italy; 129 131 University of Siena, Department of Life Sciences, Siena, Italy; 130 132 University of Urbino Carlo Bo, Department of Biomolecular Sciences, Urbino (PU), Italy; 131 133 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Baylor College of Medicine, Houston, TX, USA;134 University of Naples Federico II, Department of Translational Medical Sciences, Naples, Italy; 132 135 Institute for Research and Technology in Food and Agriculture (IRTA), Animal Breeding and Genetics Programme, Caldes de Montbui, Spain; 133 136 Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany; 134 137 UCL Queen Square Institute of Neurology, Reta Lila Weston Institute, London, UK; 135 138 Middle East Technical University, Department of Biological Sciences, Ankara, Turkey; 136 139 University of Miami, Department of Surgery and Sylvester Comprehensive Cancer Center, Miami, FL, USA;140 University of Miami, Department of Surgery, Miami, FL, USA; 137 141 Université Côte D\'Azur, CNRS, Inserm, Institut de Biologie Valrose, Nice, France; 138 142 School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China; 139 143 Universidade de São Paulo. Department of Biochemistry, Institute of Chemistry, Sao Paulo, Brazil; 140 144 University of Bologna, Department of Biomedical and Neuromotor Sciences, Bologna, Italy; 141 145 University of Rome (Tor Vergata), Department of Biology, Rome, Italy; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Laboratory of Cell Signaling, Rome, Italy; 142 146 Edinburgh Napier University, School of Applied Sciences, Edinburgh, UK; 143 147 University of Michigan, Department of Neurology, Ann Arbor, MI, USA; 144 148 Pulmonology Department, Hospital del Mar-IMIM, Pompeu Fabra University, CIBERES, Barcelona, Spain; 145 149 University of Limerick, Department of Biological Sciences, Limerick, Ireland; University of Limerick, Health Research Institute, Limerick, Ireland; 146 150 Danish Cancer Society Research Center, Copenhagen, Denmark; 147 151 Rice University, Department of Biosciences, Houston, TX, USA; 148 152 Columbia University, Department of Medicine, New York, NY, USA; 149 153 Jawaharlal Nehru Centre for Advanced Scientific Research, Molecular Biology and Genetics Unit, and Neuroscience Unit, Autophagy Laboratory, Jakkur, Bangalore, India; 150 154 ICAR-Indian Veterinary Research Institute, FMD Vaccine Research Laboratory, Bengaluru, India; 151 156 The University of Texas M.D. Anderson Cancer Center, Department of Experimental Therapeutics, Houston, TX, USA; 152 157 University of North Texas Health Science Center, Department of Microbiology, Immunology & Genetics, Fort Worth, TX, USA; 153 158 University of Louvain, Louvain Institute of Biomolecular Science and Technology (LIBST), Louvain-la-Neuve, Belgium; 154 159 Trinity College Dublin, School of Medicine, Trinity Translational Medicine Institute, Dublin, Ireland; 155 160 Université Paris-Saclay, INSERM UMR1195, Hôpital Le Kremlin Bicêtre, 80 rue du Général Leclerc, 94276 Kremlin-Bicêtre, France; 156 161 University of South Carolina Upstate, Spartanburg, SC, USA; 157 162 Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université, Université de Paris, Centre de Recherche des Cordeliers, Paris, France; 158 163 Francis Crick Institute, London, UK; UCL, Royal Free Hospital, London, UK; 159 164 Université Paris-Saclay, Inserm U1185, Le Kremlin-Bicêtre, France; 160 165 Université de Pau et des Pays de l’Adour, E2S UPPA, INRAE, NUMEA, 64310 Saint-Pée-sur-Nivelle, France; 161 682 University of Sao Paulo, Institute of Biomedical Sciences, Sao Paulo, SP, Brazil; 162 167 Emory University School of Medicine, Division of Endocrinology, Metabolism and Lipids, Atlanta, GA, USA; 163 168 University of Pennsylvania, Perelman School of Medicine, PENN Center for Pulmonary Biology, Lung Epithelial Biology Laboratories, Philadelphia, PA, USA; 164 169 Mater Research Institute, University of Queensland, Brisbane Australia; 165 170 Ludwig-Maximilians-Universität München, Munich Cluster for Systems Neurology, München, Germany; 166 171 Hannover Medical School, Department for Clinical Immunology and Rheumatology, Hannover, Germany; 167 172 University of Rome “Tor Vergata”, Department of Clinical Sciences and Translational Medicine, Rome, Italy; 168 173 Tufts University, USDA Human Nutrition Research Center on Aging, Laboratory for Nutrition and Vision Research, Boston, MA, USA;174 Universidad Cardenal Herrera-CEU, CEU Universities, School of Health Sciences, Department of Biomedical Sciences, Moncada, Spain; 169 175 Bar-Ilan University, Azrieli Faculty of Medicine, Safed, Israel; 170 176 University Medical Center of the Johannes Gutenberg University, Institute of Pathobiochemistry, Mainz, Germany; 171 177 Boston University, Metcalf Science Center, Boston, MA, USA; 172 178 Sorbonne Université, CNRS UMR8226, Institut de Biologie Physico-Chimique, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, Paris, France; 173 179 Italian Liver Foundation, Trieste, Italy; 174 180 University of Rome “Sapienza”, Department of Clinical and Molecular Medicine, Laboratory affiliated to Istituto Pasteur Italia Fondazione Cenci Bolognetti, Rome, Italy; 175 181 Centro Nacional de Biotecnología-CNB-CSIC, Madrid, Spain; 176 182 Universidad Autónoma de Madrid, Departamento de Biología Molecular, Madrid, Spain; 177 183 University of São Paulo, Faculty of Pharmaceutical Sciences, Department of Pathophysiology, Sao Paulo, Brazil; 178 184 Universidad Mayor, Center for Integrative Biology, Santiago, Chile; 179 185 University of Oklahoma Health Sciences Center/Stephenson Cancer Center, Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, Oklahoma City, OK, USA; 180 186 UMR 7242 “Biotechnology and cellular signaling”, CNRS, Illkirch, France; 181 187 Washington University in Saint Louis, School of Medicine, Department of Psychiatry, Saint Louis MO, USA; 182 188 Universidad Francisco de Vitoria, Madrid, Spain; 183 189 Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute, Adelaide, Australia; 184 190 University of Copenhagen, Department of Biology, Copenhagen, Denmark; 185 191 University of Lausanne Hospital and Lausanne University, Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne, Switzerland; 186 192 Queen Mary University of London, Blizard Institute, Centre for Cell Biology and Cutaneous Research, London, UK; 187 193 University of Cologne and University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; Center for Molecular Medicine, Cologne, Germany; 188 194 University of Massachusetts Medical School, Department of Molecular, Cell and Cancer Biology (MCCB), Worcester, MA, USA; 189 195 Magna Graecia University, Department of Health Sciences, Catanzaro, Italy; 190 196 Université Paris Descartes, Institut Cochin, INSERM U1016, CNRS UMR8104, Paris, France; 191 197 CNRS, Université de Bordeaux, Laboratoire de Biogenèse Membranaire UMR5200, 33140 Villenave d\'Ornon, Bordeaux, France; Université de Bordeaux, CNRS, Laboratoire de Biogenèse Membranaire UMR5200, Villenave d\'Ornon, Bordeaux, France; 192 198 Université du Québec à Trois-Rivières, Département de Biologie Médicale, Trois-Rivières, Québec, Canada; 193 199 University of Michigan, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA; 194 200 University of Montpellier, CNRS/UMR5235 LPHI, Montpellier, France; 195 1092 Bristol Medical School, University of Bristol, Bristol, UK; 196 201 Ghent University, VIB Center for Inflammation Research, Ghent, Belgium; 197 202 University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK; 198 203 University of New Mexico, Department of Molecular Genetics and Microbiology, Department of Neurology, Albuquerque, NM, USA; 199 204 Comenius University, Department of Biochemistry, Bratislava, Slovakia; 200 205 University of Oklahoma Health Sciences Center, Department of Obstetrics and Gynecology, Oklahoma City, OK, USA; 201 206 Vanderbilt University Medical Center, Vanderbilt Eye Institute, Nashville, TN, USA; 202 207 Department of Biophysics, Post Graduate Institute of Medical Education and Research, Chandigarh, India; 203 208 Louisiana State University Health Sciences Center-Shreveport, Department of Pathology and Translational Pathobiology, Shreveport, LA, USA; 204 209 National Institute of Technology Rourkela, Department of Life Science, Cancer and Cell Death Laboratory, Rourkela, Odisha, India; 205 210 Michigan Technological University, Department of Chemistry, Houghton, MI, USA; 206 211 Dalian Medical University, College of Basic Medical Sciences, Dalian, China; 207 212 Garvan Institute of Medical Research, St Vincent\'s Medical School, Faculty of Medicine, UNSW, Sydney, Australia; 208 213 Eötvös Loránd University (ELTE), Department of Genetics, Budapest, Hungary; 209 214 Federal University of São Paulo, Department of Pharmacology, Paulista School of Medicine, São Paulo, Brazil; 210 215 University Hospital of North Norway, The Heart and Lung Clinic; University of Tromso-The Artic University of Norway, Department of Clinical Medicine, Tromso, Norway; 211 216 Norwegian University of Science and Technology, Department of Biomedical Laboratory Science, Trondheim, Norway; 212 217 University of York, Department of Biology, Heslington, UK; 213 218 University of Valencia, Faculty of Medicine, Department of Physiology, Valencia, Spain; CIBERehd, Valencia, Spain; 214 219 University of Lodz, Faculty of Biology and Environmental Protection, Lodz, Poland; 215 220 Linköping University, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping, Sweden; 216 221 Karolinska Institutet, Department of Women\'s and Children’s Health, Stockholm, Sweden AND Karolinska University Hospital, Pediatric Oncology, Stockholm, Sweden; 217 222 Indiana University School of Medicine, Department of Microbiology and Immunology, Indianapolis, IN, USA; 218 223 St. Jude Children\'s Research Hospital, Department of Immunology, Memphis, TN, USA; 219 224 University of Zagreb, School of Medicine, Croatian Institute for Brain Research, Zagreb, Croatia; 220 225 University of Pennsylvania, Department of Basic and Translational Sciences, Philadelphia, PA, USA; 221 226 Burnet Institute, Melbourne, Australia; 222 227 University College Cork, Department of Pharmacology and Therapeutics, County Cork, Ireland; 223 228 INMG, INSERM, CNRS, University of Lyon, Lyon, France; 224 229 University of Padova, Department of Molecular Medicine, Padova, Italy; 225 230 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France; 226 231 National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Neurosciences and Cellular and Structural Biology Division (NCSBD), Bethesda, MD, USA; 227 232 West Virginia University, Department of Surgery, Morgantown, WV, USA; 228 233 The Open University, School of Life, Health and Chemical Sciences, Faculty of Science, Technology, Engineering and Mathematics, Milton Keynes, UK; 229 235 University of Rome Tor Vergata, Department of Biology, Rome, Italy;447 IRCCS Bambino Gesù Children’s Hospital, Department of Pediatric Hemato-Oncology and Cell and Gene Therapy, Rome, Italy; 230 236 Albert Ludwigs University of Freiburg, Faculty of Medicine, Institute of Molecular Medicine and Cell Research, Freiburg, Germany; 231 237 University Children’s Hospital Zurich, Children’s Research Center and Department of Oncology, Zurich, Switzerland; 232 238 University of Texas M.D. Anderson Cancer Center, Department of Leukemia, Houston, TX, USA; 233 239 Case Western Reserve University School of Medicine, Department of Pediatrics, Cleveland, OH, USA; InterRayBio, LLC, Baltimore, MD, USA; 234 240 Washington State University, Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Pullman, WA, USA; 235 241 University Santiago de Compostela, Department of Pharmacology, Veterinary Faculty, Lugo, Spain; 236 242 Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute and Department of Molecular and Human Genetics, Houston, TX, USA; 237 243 Université de Paris, PARCC, INSERM, Paris, France; 238 244 University of Alabama at Birmingham, Department of Ophthalmology and Visual Sciences, Birmingham, AL, USA; 239 245 Albert Einstein College of Medicine, Department of Developmental and Molecular Biology, Bronx, NY, USA; 240 246 Medical University of Graz, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Graz, Austria; 241 247 University Paris 13, UMR_S942 Inserm; University of Paris, Bobigny, France; 242 248 Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain; 243 249 Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala BioCenter, Department of Molecular Sciences, Uppsala, Sweden; 244 166 Stanford University, Department of Chemical & Systems Biology, Stanford, CA, USA;682 University of Sao Paulo, Institute of Biomedical Sciences, Sao Paulo, SP, Brazil; 245 250 Imperial College London, Department of Life Sciences, London, UK; 246 251 The Connecticut Agricultural Experiment Station, Center for Vector Biology and Zoonotic Diseases, Department of Environmental Sciences, New Haven, CT, USA; 247 252 Goethe University, University Hospital, University Cancer Center Frankfurt (UCT), Department of Medicine, Hematology/Oncology, Frankfurt, Germany; 248 253 Danube Private University, Department of Medicine/Dental Medicine, Krems/Donau, Austria; 249 254 Georg-August-Universität Göttingen, Institute for Microbiology and Genetics, Department of Molecular Microbiology and Genetics, Göttingen, Germany; 250 255 Universidad de Chile, Instituto de Nutrición y Tecnología de los Alimentos (INTA), Santiago, Chile; 251 256 Université de Paris, Sorbonne Université, Centre de Recherche des Cordeliers, INSERM U1138, Paris, France; 252 768 University Côte d\'Azur (UCA), Institute for Research on Cancer and Aging of Nice (IRCAN), Centre National de la Recherche Scientifique (CNRS) UMR7284, Institut National de la Santé et de la Recherche Médicale (INSERM) U1081, Nice, France; 253 258 Centre des Sciences du Goût et de l\'Alimentation, AgroSup Dijon, CNRS, INRAE, University of Bourgogne Franche-Comté, Eye and Nutrition Research Group, Dijon, France; 254 259 National Autonomous University of Mexico, Faculty of Chemistry, Department of Biology, Mexico city, Mexico; 255 260 University of California San Francisco, Department of Medicine, Zuckerberg San Francisco General Hospital and TraumaCenter, San Francisco, CA, USA; 256 261 University of Copenhagen, Department of Biology, Denmark; 257 262 University of Pittsburgh, Department of Biological Sciences, Pittsburgh, PA, USA; 258 263 Washington University School of Medicine, Department of Medicine, Saint Louis, MO, USA; 259 264 Department of Human Genetics, Genentech, Inc., South San Francisco, CA, USA; 260 265 David Geffen School of Medicine at UCLA, Department of Neurology, Los Angeles, CA, USA; 261 266 University of Colorado, AMC, Department of Pharmacology, Aurora, CO, USA; 262 267 University of Minnesota, Hormel Institute, Austin, MN, USA; 263 268 University of Sao Paulo, School of Physical Education and Sport, Cellular and Molecular Exercise Physiology Laboratory, Sao Paulo, SP, Brazil; 264 269 Hospital for Sick Children, Cell Biology Program, Toronto, ON, Canada; 265 58 Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, Italy;134 University of Naples Federico II, Department of Translational Medical Sciences, Naples, Italy; 266 270 University of Insubria, Department of Biotechnology and Life Sciences, Varese, Italy; 267 271 Monash University, School of Biological Sciences, Melbourne, Victoria, Australia; 268 272 University of Salento, Dept of Biological and Environmental Sciences and Technologies, Lecce, Italy; 269 273 Institut Pasteur, Biologie des Bactéries Intracellulaires and CNRS UMR 3525, Paris, France; 270 274 University of Pittsburgh, Aging Institute, Department of Medicine, Pittsburgh, PA, USA; 271 275 University Duisburg-Essen, Essen University Hospital, Department of Gastroenterology and Hepatology, Essen, Germany; Department of Gastroenterology, Hepatology & Endocrinology, Hannover Medical School, Hannover, Germany; 272 276 Thomas Jefferson University, Department of Pathology, Anatomy, and Cell Biology, Philadelphia, PA, USA; 273 277 Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA; 274 278 University of Arizona, Department of Molecular and Cellular Biology, Tucson, AZ, USA; 275 279 University of Iowa, Iowa City, IA, USA; 276 280 Montana BioAg. Inc. Missoula, MT, USA; 277 281 Universidad de Chile, Facultad de Odontología, Autophagy Research Center (ARC), Santiago, Chile; 278 282 KU Leuven, Department of Cellular & Molecular Medicine, Campus Gasthuisberg, Leuven, Belgium; 279 283 University of Medicine and Pharmacy of Craiova, Department of Medical Genetics, Craiova, Romania; 280 284 King\'s College London, School of Cardiovascular Medicine & Sciences, The Rayne Institute, St Thomas\' Hospital, London, UK; 281 285 University of Cordoba, Department of Cell Biology, Physiology and Immunology, Córdoba, Spain; 282 286 The Rockefeller University, Laboratory of Cellular and Molecular Neuroscience, New York, NY, USA; 283 287 Stockholm University, The Wenner-Gren Institute, Department of Molecular Biosciences, Stockholm, Sweden; 284 288 University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Biological Chemistry Section, Verona, Italy; 285 289 Departmento de Biología Celular e Histología, Facultad de Biología, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB)-Arrixaca, Murcia, Spain; 286 290 Universidad Nacional Autónoma de México, Faculty of Sciences, Department of Cell Biology, Fibrosis Lab, Mexico City, Mexico; 287 291 New York University School of Medicine, Skirball Institute and Department of Microbiology, New York, NY, USA; 288 292 Wenzhou Medical University, State Key Laboratory of Ophthalmology, Optometry and Visual Science, School of Optometry and Ophthalmology and the Eye Hospital, Wenzhou, China; 289 293 University of Louisville, Pediatric Research Institute, Department of Pediatrics, Louisville, KY, USA; 290 294 Rutgers University, The State University of New Jersey, Department of Cell Biology and Neuroscience, Piscataway, NJ, USA; 291 295 University of Barcelona, Department of Biochemistry and Molecular Biomedicine, and Network Center for Biomedical Research in Pathophysiology of Obesity and Nutrition (CIBEROBN), Barcelona, Spain; 292 296 University of Las Palmas de Gran Canaria, Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), Las Palmas de Gran Canaria, Spain; Norwegian School of Sport Sciences, Department of Physical Performance, Oslo, Norway; 293 297 University of Alabama, Department of Biological Sciences, Tuscaloosa, AL, USA; 294 298 University of Georgia, Department of Kinesiology, Athens, GA, USA; 295 299 Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, Italy; 296 300 University of Zaragoza, Faculty of Veterinary-IIS Aragón, IA2-CITA, CIBERNED, Laboratory of Genetics and Biochemistry (LAGENBIO), Zaragoza, Spain; 297 301 University of São Paulo, Department of Immunology, Laboratory of Transplantation Immunobiology, São Paulo, SP, Brazil; 298 302 CNRS, Institut Curie, Paris, France; 299 303 University of Bordeaux, CNRS, IBGC, UMR 5095, Bordeaux, France; 300 304 University of London, The Royal Veterinary College, Department of Comparative Biomedical Sciences, UCL Consortium for Mitochondrial Research, London, UK; 301 305 Loyola University, Stritch School of Medicine, Department of Microbiology and Immunology, Chicago, IL, USA; 302 306 University of Ottawa, Department of Chemistry and Biomolecular Sciences and Department of Biochemistry, Microbiology and Immunology, Host-Microbe Interactions Laboratory, Ottawa, ON, Canada; 303 307 University of Rome “Tor Vergata”, Department of Biology, Rome, Italy; 304 308 Università di Sassari, Dipartimento di Scienze Biomediche, Sassari, Italy; 305 2311 Université Côte d\'Azur, Université Nice Sophia Antipolis, CEA/DRF/BIAM, Faculté de Médecine, UMR E-4320 TIRO-MATOs, Nice, France; 306 310 Universidad San Sebastián, Centro de Biología Celular y Biomedicina (CEBICEM), Facultad de Medicina y Ciencia, Santiago, Chile; 307 64 Federal University of São Paulo, Department of Medicine, Nephrology Division, Laboratory of Clinical and Experimental Immunology, São Paulo, SP, Brazil; 308 311 University of Toronto, Sinai Health System, Lunenfeld-Tanenbaum Research Institute, Toronto, Ontario, Canada; 309 313 IRBLleida-University of Lleida,Department of Experimental Medicine, Lleida, Spain; 310 314 Xiamen University School of Medicine, Fujian Provincial Key Laboratory of Reproductive Health Research, Xiang\'an, Xiamen, China; 311 315 University of Campania “L. Vanvitelli”, Department of Precision Medicine, Naples, Italy; Institute of Genetic Research, Biogem scarl, Laboratory of Molecular and Precision Oncology, Ariano Irpino (AV), Italy; 312 316 Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña (UDC), A Coruña, Spain; 313 317 University of Wisconsin, Department of Surgery, Madison, WI, USA; 314 318 University of Geneva, Department of Biochemistry, Faculty of Science, Switzerland; 315 319 Universidad Nacional Autónoma de México, Institute of Biotechnology, Plant Molecular Biology Department, Cuernavaca, Morelos, México; 316 320 University of Coimbra, Faculty of Medicine and CNC-Center for Neuroscience and Cell Biology, Coimbra, Portugal; 317 321 University of Arizona Cancer Center, Tucson, AZ, USA; 318 309 Université Côte d\'Azur, Université Nice Sophia Antipolis, CEA/DRF/Institut Frédéric Joliot, Faculté de Médecine, UMR E-4320 TIRO-MATOs, Nice, France; 319 322 Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, British Columbia, Canada; 320 323 University of Graz, Institute of Molecular Biosciences, NAWI Graz, Graz, Austria; 321 324 Federal University of Rio de Janeiro, Institute of Microbiology, Department of Immunology, Rio de Janeiro, Brazil; 322 325 Polytechnic University of Marche, Department of Life and Environmental Sciences, Ancona, Italy; 323 326 University of Modena and Reggio Emilia, Department of Biomedical, Metabolic and Neural Sciences, Modena, Italy; 324 327 Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR7258, Aix-Marseille Université U105, Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France; 325 328 Functional Genomics of Cardiomyopathies, Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany; 326 329 University of Alabama at Birmingham, Department of Medicine, Pulmonary, Allergy, and Critical Care Medicine, Birmingham VA Medical Center, Birmingham, AL, USA; 327 330 Universidade de Lisboa, Faculty of Pharmacy, Research Institute for Medicines (iMed.ULisboa), Lisboa, Portugal; 328 331 Aix Marseille Univ, CNRS, LISM, Institut de Microbiologie de la Méditerranée, Marseille, France; 329 332 Universitat Autònoma de Barcelona, Institute of Neuroscience, Barcelona, Spain; 330 333 Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Department of Biological Chemistry; Networking Biomedical Research Centre on Hepatic and Digestive Diseases (CIBER-EHD), Barcelona, Spain; 331 334 University of New Mexico Health Sciences Center, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Albuquerque, NM, USA; 332 335 Universidad de Valparaíso, Centro Interdisciplinario de Neurociencia de Valparaíso, Laboratory of Molecular Sensors, Valparaíso, Chile; 333 336 Complutense University, Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Department of Biochemistry and Molecular Biology, School of Biology, Madrid, Spain; 334 337 Université de Paris, Sorbonne Université, Centre de Recherche des Cordeliers, INSERM U1138, Team “Metabolism, Cancer & Immunity”, Paris, France; Gustave Roussy Cancer Campus, Metabolomics and Cell Biology Platforms, Villejuif, France; 335 338 Division of Medical Genetics, Fondazione IRCCS-Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; 336 339 Universidad de Concepción, Department of Biochemistry and Molecular Biology, Concepción, Chile; 337 330 Universidade de Lisboa, Faculty of Pharmacy, Research Institute for Medicines (iMed.ULisboa), Lisboa, Portugal;340 Universidade NOVA de Lisboa, Faculdade de Ciências e Tecnologia, Departamento Ciências da Vida, UCIBIO, Caparica, Portugal; 338 341 Universidad de La Laguna, Departamento de Ciencias Médicas Básicas, Tenerife, Spain; 339 342 Universidad Nacional Autónoma de México (UNAM), Instituto de Fisiologia Celular, Ciudad Universitaria, Ciudad de México, México; 340 343 The Scripps Research Institute, Department of Molecular Medicine, La Jolla, CA, USA; 341 344 University of Coimbra, Portugal, CNC – Center for Neuroscience and Cell Biology & Faculty of Pharmacy, Coimbra, Portugal; 342 345 University of Pisa, Interdepartmental Research Centre on Biology and Pathology of Aging, Pisa, Italy; 343 346 University of Innsbruck, Institute for Biomedical Aging Research, Department of Molecular Biology, Innsbruck, Austria; 344 347 Biomedical Research Institute of Murcia, IMIB-Arrixaca, Telomerase, Cancer and Aging Group, Surgical Department, Murcia, Spain; 345 348 Research Center Borstel, Leibniz Lung Center, Priority Area Infections, Division Cellular Microbiology, Borstel, Germany; 346 234 Danish Cancer Society Research Center, Center for Autophagy, Recycling and Disease (CARD), Cell Stress and Survival Unit, Copenhagen, Denmark; IRCCS Bambino Gesù Children’s Hospital, Department of Pediatric Hemato-Oncology and Cell and Gene therapy, Rome, Italy; University of Rome Tor Vergata, Department of Biology, Rome, Italy; 347 349 Medical University of Bialystok, Department of Pharmaceutical Biochemistry, Bialystok, Poland; 348 350 Ospedale San Raffaele and Vita-Salute San Raffaele University, Division of Genetics and Cell Biology, Milano, Italy; 349 351 Hospital Universitari de Tarragona Joan XXIII, Institut d\'Investigació Sanitària Pere Virgili, Madrid, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; 350 352 University of Minho, School of Medicine, Life and Health Sciences Research Institute (ICVS), Braga, Portugal; 351 353 Universidade Federal de São Paulo, Department of Morphology and Genetics, São Paulo, SP, Brazil; 352 354 University of Tuscia, Department for Innovation in Biological, Agro-food, and Forest systems (DIBAF), Viterbo, Italy; 353 355 Ege University, Faculty of Medicine, Department of Medical Biology, Izmir, Turkey; 354 356 School of Pharmacy, Jeonbuk National University, Jeollabuk-do, Republic of Korea; 355 357 Karolinska Institutet, Department of Physiology and Pharmacology, Stockholm, Sweden; 356 358 Kaohsiung Medical University, Department of Pathology, Kaohsiung City, Taiwan; 357 359 University of Calcutta, Department of Biotechnology and Dr. B.C. Guha Centre for Genetic Engineering and Biotechnology, Kolkata, India; 358 360 Saha Institute of Nuclear Physics, Biophysics & Structural Genomics Division, HBNI, Kolkata, India; 359 361 Ehime University, Department of Aquatic Life Sciences, Ainan, Ehime, Japan; 360 362 Justus-Liebig-University Giessen, Institute of Medical Microbiology, Giessen, Germany; 361 363 Université Côte d\'Azur, INSERM, CNRS, IPMC, team labeled Laboratory of Excellence (LABEX) Distalz, Valbonne, France; 362 31 University of Crete, School of Medicine, Laboratory of Clinical Microbiology and Microbial Pathogenesis, Voutes, Heraklion, Crete, Greece; Foundation for Research and Technology, Institute of Molecular Biology and Biotechnology (IMBB), Heraklion, Crete, Greece; 363 364 The University of Hong Kong, Li Ka Shing Faculty of Medicine, Department of Obstetrics and Gynecology, Hong Kong, China; 364 365 Queen\'s University, Department of Biomedical and Molecular Sciences, Kingston, Ontario, Canada; 365 366 The Chinese University of Hong Kong, School of Life Sciences, Shatin N.T., Hong Kong, China; 366 367 The Chinese University of Hong Kong, School of Biomedical Sciences, Hong Kong, China; 367 368 The Chinese University of Hong Kong, Department of Anaesthesia and Intensive Care, Hong Kong, China; 368 369 Tulane University School of Medicine, Department of Pharmacology, New Orleans, LA, USA; 369 370 National Cheng Kung University, College of Medicine, Department of Microbiology and Immunology, Tainan, Taiwan; 370 371 University of California, Berkeley, Department of Molecular Biology and Cell Biology, Berkeley, CA, USA; University of California, Berkeley, California Institute for Quantitative Biosciences, Berkeley, CA, USA; 371 372 National University of Singapore, Faculty of Sciences, Department of Pharmacy, Singapore; 372 373 Southeast University, School of Medicine, Department of Physiology, Nanjing, Jiangsu, China; 373 374 University of East Anglia, School of Biological Sciences, Norwich Research Park, UK; 374 375 Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, University of Strasbourg, Illkirch, France; 375 376 NCR Biotech Science Cluster, Translational Health Science and Technology Institute, Complex Analysis Group, Faridabad, India; 376 377 Banaras Hindu University, Institute of Science, Department of Zoology, Lanka, Varanasi, Uttar Pradesh, India; 377 378 University of Washington, Department of Laboratory Medicine, Seattle, WA, USA; 378 379 Institute of Life Sciences, Bhubaneswar, Odisha, India; 379 380 UCL Institute of Ophthalmology, London, UK; 380 381 National Cheng Kung University, Department of Biochemistry and Molecular Biology, Tainan, Taiwan; 381 382 Academia Sinica, Institute of Biological Chemistry, Taipei, Taiwan; 382 383 University of Southern California, Center for Craniofacial Molecular Biology, Los Angeles, CA, USA; 383 384 University of Minnesota Medical School, Department of Laboratory Medicine and Pathology, Minneapolis, MN, USA; 384 385 Qingdao University, Institute of Brain Science and Disease, Qingdao, Shandong, China; 385 386 Army Medical University (Third Military Medical University), Daping Hospital, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Laboratory for the Prevention and Rehabilitation of Training Related Injuries, Chongqing, China; 386 387 Third Military Medical University, Southwest Hospital, Institute of Pathology and Southwest Cancer Centre, Chongqing, China; 387 388 Changhua Christian Hospital, Department of Otorhinolaryngology-Head and Neck Surgery, Changhua, Taiwan; 388 389 Wuhan Sports University, College of Health Science, Tianjiu Research and Development Center for Exercise Nutrition and Foods, Hubei Key Laboratory of Exercise Training and Monitoring, Wuhan, Hubei, China; 389 390 College of Life Sciences, Nankai University, Tianjin, China; 390 391 Wuhan University, School of Pharmaceutical Sciences, Zhongnan Hospital, Wuhan, China; 391 392 Duke University, Department of Medicine, Durham, NC, USA; 392 393 Chinese Academy of Sciences, Institute of Modern Physics, Lanzhou, China; 393 394 University of Sydney, Sydney Medical School, Renal Medicine, St Leonards, NSW, Australia; 394 395 Temple University, Lewis Katz School of Medicine, Cardiovascular Research Center and Department of Physiology, Philadelphia, PA, USA; 395 396 Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Dermatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, Jiangsu, China; 396 397 Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China; 397 398 Tsinghua University, School of Life Sciences, Beijing, China; 398 399 Peking University School of Basic Medical Science, Department of Immunology, Beijing, China; 399 400 Research Institute in Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada; 400 401 Mackay Memorial Hospital, Department of Radiation Oncology, Taipei, Taiwan; 401 402 Sun Yat-sen University, School of Life Science, Guangzhou, China; 402 403 Wuhan University, School and Hospital of Stomatology, Key Lab of Oral Biomedicine of Ministry of Education (KLOBME), Wuhan, Hubei, China; 403 404 2nd Affiliated Hospital of Zhejiang University School of Medicine, Department of Respiratory and Critical Care Medicine, Hangzhou, China; 404 405 University of Texas Southwestern Medical Center, Department of Molecular Biology, Dallas, Texas, USA; 405 406 Purdue University, Department of Botany and Plant Pathology, West Lafayette, IN, USA; 406 407 Wuhan University, Hubei Key laboratory of Cell Homeostasis, College of Life Sciences, Wuhan, China; 407 408 Capital Medical University, Beijing Ditan Hospital, Liver Disease Center, Beijing, China; 408 409 Northwestern University Feinberg School of Medicine, Department of Neurology & Lou & Jean Malnati Brain Tumor Institute, Chicago, IL, USA; 409 410 Albert Einstein College of Medicine, Department of Genetics, Bronx, NY, USA; 410 411 The University of Texas Health Science Center at Houston, Department of Integrative Biology and Pharmacology, Houston, TX, USA; 411 412 National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA; 412 413 East China Normal University, School of Life Sciences, Shanghai, China; 413 414 University of Florida, Food Science and Human Nutrition Department, Gainesville, FL, USA; 414 415 Zhejiang University, College of Pharmaceutical Sciences, Institute of Pharmacology and Toxicology, Hangzhou, Zhejiang, China; 415 416 National Cancer Center Korea, Goyang, Gyeonggi, Korea; 416 417 National University of Singapore, Yong Loo Lin School of Medicine, Department of Biochemistry, Singapore;936 National University of Singapore, Yong Loo Lin School of Medicine, Strategic Research Programme in Precision Medicine, Singapore; 417 418 Lomonosov Moscow State University, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russia; 418 419 University of Pennsylvania, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA; 419 420 National Cheng Kung University, College of Medicine, Department of Pharmacology, Tainan, Taiwan; 420 421 Sun Yat-Sen University, School of Pharmaceutical Sciences, Guangzhou, China; 421 422 INSERM U1242, University of Rennes, Rennes, France; Centre de Lutte Contre le Cancer Eugène Marquis, Rennes, France; 422 423 University of North Carolina at Charlotte, Department of Biological Sciences, Charlotte, NC, USA; 423 424 The University of Hong Kong, Queen Mary Hospital, Department of Paediatrics and Adolescent Medicine, Pokfulam, Hong Kong, China; 424 425 University of Milano-Bicocca, Department of Biotechnology and Biosciences, Milan, Italy; 425 426 Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Siena, Italy; Core Research Laboratory, Istituto per lo Studio, la Prevenzione e la Rete Oncologica, Siena, Italy.; 426 427 The Norwegian Radium Hospital, Institute for Cancer Research, Department of Molecular Cell Biology, Montebello, Oslo, Norway; University of Oslo, Faculty of Mathematics and Natural Sciences, The Department of Biosciences, Oslo, Norway;428 The Norwegian Radium Hospital, Institute for Cancer Research, Department of Molecular Cell Biology, Montebello, Oslo, Norway; University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, Centre for Cancer Cell Reprogramming, Oslo, Norway; 427 429 IEO, European Institute of Oncology IRCCS, IFOM-IEO Campus, Department of Experimental Oncology, Milan, Italy; 428 430 University of Chile, Faculty of Chemical and Pharmaceutical Sciences, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile; 429 431 Taipei Veterans Generals Hospital, Department of Medical Research, Taipei, Taiwan.; 430 432 National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), Rocky Mountain Laboratories (RML), Laboratory of Virology, Innate Immunity and Pathogenesis Section, Hamilton, MT, USA; 431 433 Institute of Translational Pharmacology, National Research Council, Rome, Italy; European Center for Brain Research, Laboratory of Resolution of Neuroinflammation, IRCCS Santa Lucia Foundation, Rome, Italy; 432 434 Kyungpook National University, Department of Life Science, Deagu, Korea; 433 435 Wonkwang University School of Medicine, Department of Microbiology, Iksan, Jeonbuk, Korea; 434 436 Weill Cornell Medicine, Department of Medicine, New York, NY, USA; 435 437 Weill Cornell Medicine, Division of Nephrology and Hypertension, Joan and Sanford I. Weill Department of Medicine, New York, NY, USA; 436 438 CSIR-Indian Institute of Chemical Biology, Kolkata, India; 437 439 BC Cancer Research Centre, Department of Experimental Therapeutics, Vancouver, BC, Canada; 438 440 University of Pittsburgh School of Medicine, Department of Pathology, Pittsburgh, PA, USA; 439 441 National University of Singapore, Yong Loo Lin School of Medicine, Department of Physiology; National University of Singapore, LSI Neurobiology Programme; National University of Singapore, Institute for Health Innovation and Technology; National University Hospital Singapore, Centre for Healthy Longevity; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore; 440 442 Konkuk University School of Medicine, Department of Ophthalmology, Seoul, Korea; 441 443 Max-Planck-Institut für Molekulare Pflanzenphysiologie, Potsdam, Germany; 442 444 University of Ulsan College of Medicine, Asan Medical Center, Department of Psychiatry, Seoul, Korea; 443 445 The Catholic University of Korea, Seoul St, Mary\'s Hospital, Department of Ophthalmology and Visual Science, Seoul, Kor; 444 446 Institute of Cancer Research, Cancer Research UK Cancer Imaging Centre, Division of Radiotherapy and Imaging, London, UK; 445 447 IRCCS Bambino Gesù Children’s Hospital, Department of Pediatric Hemato-Oncology and Cell and Gene Therapy, Rome, Italy; 446 448 Nencki Institute of Experimental Biology of Polish Academy of Sciences, Neurobiology Center, Laboratory of Molecular Neurobiology, Warsaw, Poland; 447 449 University of Chile, Institute of Nutrition and Food Technology (INTA), Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile; 448 450 University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Pediatrics, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine (CMMC), Cologne, Germany; 449 451 University of Rome “La Sapienza”, Rome, Italy; 450 452 University of Liverpool, Institute of Translational Research, Cellular and Molecular Physiology, Liverpool, UK;492 Molecular Physiology and Cell Signaling, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK; 451 453 Università di Milano, Department of Biomedical and Clinical Sciences L. Sacco, Milan, Italy; 452 454 Istituto Superiore di Sanità, Department of Infectious Diseases, Rome, Italy; 453 455 Institut Necker-Enfants Malades (INEM), INSERM U1151/CNRS UMR 8253, Université de Paris, Paris, France; 454 456 The Hebrew University of Jerusalem, The Institute for Medical Research Israel-Canada, Department of Biochemistry and Molecular Biology, Ein Karem, Jerusalem, Israel; 455 457 University Roma Tre, Department of Science, LIME, Rome, Italy; 456 458 National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Pediatric Translational Research Branch, Bethesda, MD, USA; 457 459 Institut d\'Investigacions Biomèdiques de Barcelona (CSIC, IDIBAPS), and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain; 458 460 University of Belgrade, Institute for the Application of Nuclear Energy (INEP), Belgrade, Serbia; 459 461 Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus UAB, Bellaterra, Barcelona, Spain; 460 462 University of Sheffield, Department of Biomedical Science, Firth Court, Western Bank, Sheffield, UK; 461 463 Instituto de Histología y Embriología (IHEM)-Universidad Nacional de Cuyo-CONICET, Facultad de Ciencias Médicas, Mendoza, Argentina; 462 464 Yale University School of Medicine, Department of Neuroscience and Department of Cell Biology, New Haven, CT, USA; 463 465 Clermont-Auvergne University, INRAE, Human Nutrition Unit, F-63000, Clermont-Ferrand, France; 464 466 University of Pavia, Department of Biology and Biotechnology “L. Spallanzani”, Pavia, Italy; 465 467 Federal University of São Carlos, Department of Gerontology, São Carlos, SP, Brazil; 466 468 Department of Pathology and Experimental Therapeutics and Institute of Biomedicine of the University of Barcelona (IBUB), Bellvitge University Hospital-IDIBELL, Hospitalet de Llobregat; University of Brescia, Department of Molecular and Translational Medicine, Brescia BS, Italy; 467 469 National Institutes of Health, NIAMS, Lymphocyte Nuclear Biology, Bethesda, MD, USA; 468 595 Rutgers University, Department of Biological Sciences, Newark, NJ, USA; 469 471 National Institutes of Health, National Institute on Aging, Laboratory of Neurogenetics, Bethesda, MD, USA; 470 472 University of Manitoba, Department of Medical Microbiology & Infectious Diseases, Winnipeg, Manitoba, Canada; 471 473 Johns Hopkins University, Department of Molecular Microbiology and Immunology, Baltimore, MD, USA; 472 474 University (Magna Graecia) of Catanzaro, Department of Health Sciences, Catanzaro, Italy; 473 475 Umeå University, Umeå Centre for Microbial Research (UCMR), Department of Chemistry, Umeå, Sweden; 474 476 OncoRay National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology - OncoRay, Dresden, Germany; German Cancer Consortium (DKTK), Partner site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany;477 OncoRay National Center for Radiation Research in Oncology, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany; 475 478 University of Genoa, DIMES Department of Experimental Medicine, Human Anatomy, Genoa, Italy; 476 479 University of Michigan Medical School, Department of Neurology, Ann Arbor, MI, USA; 477 480 University of Zürich, Schlieren Campus, Center for Molecular Cardiology, Schlieren, Switzerland; 478 481 University of Oviedo, Department of Morphology and Cell Biology, Oviedo, Spain; 479 482 University of Melbourne, Department of Pharmacology and Therapeutics, Melbourne, Victoria, Australia; 480 483 CSIC-Universidad de Sevilla, Instituto de Bioquímica Vegetal y Fotosíntesis, Sevilla, Spain; 481 484 Universidad de Chile, Facultad de Odontología, Advanced Center for Chronic Diseases, Santiago, Chile; 482 485 Università degli Studi di Milano, Dipartimento di Scienze Farmacologiche e Biomolecolari, Centro di Eccellenza per lo studio delle Malattie Neurodegenerative, Milano, Italy; 483 998 Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary; 484 487 Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Investigación Sanitaria La Paz (IdiPaz), Instituto de Investigaciones Biomédicas (Alberto Sols) UAM-CSIC, Madrid, Spain; Universidad Autónoma de Madrid, School of Medicine, Department of Biochemistry, Madrid, Spain; 485 488 Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Molecular Immunology and Cancer Pharmacology Group, Beijing, China; 486 489 Sun Yat-sen University, School of Life Sciences, MOE Key Laboratory of Gene Function and Regulation, Guangzhou, Guangdong, China; 487 1862 Medical Research Institute, Wuhan University, Wuhan, China; 488 491 The Chinese University of Hong Kong, School of Life Sciences, Centre for Cell & Developmental Biology and State Key Laboratory of Agrobiotechnology, Shatin, New Territories, Hong Kong, China; 489 645 Université Paris-Saclay, CEA, 1035 CNRS, Institute for Integrative Biology of the Cell (I2BC), INSERM U1280, Gif-sur-Yvette, France; 490 493 University of Mar del Plata, Department of Biology and Chemestry, Mar del Plata, BA, Argentina; 491 494 McGill University Health Centre, Montréal, QC, Canada; 492 495 Emory University School of Medicine, Department of Medicine, Atlanta, GA, USA; 493 496 Medical University of Lublin, Department of Pathophysiology, Lublin, Poland; 494 497 University of Bologna, Department of Medical and Surgical Sciences; Rizzoli Orthopaedics Institute, Laboratory of Immunorheumatology and Tissue Regeneration, Bologna, Italy; 495 498 University Campus Bio-Medico, Department of Medicine, Rome, Italy; 496 499 Istituto Dermopatico dell\'Immacolata, IDI-IRCCS, Rome, Italy; 497 500 University of Florida, Department of Physical Therapy, Gainesville, FL, USA; 498 501 University “G. D\'Annunzio”, Department of Medical Sciences DSMOB, Chieti, Italy; Regina Elena National Cancer Institute, Department of Research, Rome, Italy; 499 502 Federal University of Sergipe, Department of Pharmacy, São José, SE, Brazil; 500 72 Max Planck Institute for Biology of Ageing and CECAD, University of Cologne, Germany;503 University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Pediatrics, Cologne, Germany; 501 504 University of Nevada, Reno School of Medicine, Department of Pharmacology, Reno, NV, USA; 502 505 Gregor Mendel Institute, Vienna Biocenter, Vienna, Austria; 503 506 University of Naples Federico II, Department of Pharmacy, Naples, Italy; 504 507 Xi\'an Jiaotong University, Department of Public Health, Xi\'an, Shaanxi, China; 505 508 The First Hospital of Jilin University, Laboratory of Cancer Precision Medicine, Changchun, Jilin, China; 506 509 Model Animal Research Center of Nanjing University, Nanjing, Jiangsu, China; 507 510 University of Salerno, Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, Baronissi, SA, Italy; 508 511 University of Padova, Department of Biology, Padova, Italy; 509 512 Research Center Borstel, Cellular Microbiology, Borstel, Germany; 510 513 University of Clermont Auvergne, M2iSH (Microbes, Intestine, Inflammation and Susceptibility of the Host), UMR 1071 Inserm, INRA USC 2018, CRNH, Clermont-Ferrand, France; 511 514 Christian-Albrechts-University Kiel, Biochemical Institute, Kiel, Germany; 512 515 Karolinska Institutet, Biomedicum, Department of Cell and Molecular Biology, Stockholm, Sweden; 513 516 University of South Florida, Morsani College of Medicine, Department of Molecular Medicine and USF Health Byrd Alzheimer\'s Research Institute, Tampa, FL, USA; Institute for Biological Instrumentation of Russian Academy of Sciences, Laboratory of New Methods in Biology, Pushchino, Moscow region, Russia;517 University of South Florida, Morsani College of Medicine, Department of Molecular Medicine, Tampa, FL, USA; 514 518 Texas Tech University Health Sciences Center, Department of Pharmaceutical Sciences, Amarillo, TX, USA; 515 519 Cleveland Clinic, Department of Gastroenterology, Hepatology and Nutrition, Cleveland, OH, USA; 516 520 MD Anderson Cancer Center, Department of Gynecologic Oncology and Reproductive Medicine, Houston, TX, USA; 517 521 Tulane University Health Sciences Center, Department of Pathology and Laboratory Medicine, New Orleans, LA, USA; 518 522 Max-Delbrück-Center for Molecular Medicine, Department of Crystallography, Berlin, Germany; 519 524 Institute of Life Sciences, School of Medicine, Swansea University, Swansea, Wales, UK; 520 525 University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, MA, USA; 521 526 Stellenbosch University, Department of Physiological Sciences, Stellenbosch, Western Cape, South Africa; 522 527 University of Dundee School of Medicine, Division of Cellular Medicine, Dundee, Scotland, UK; 523 528 University of Calabria, Department of Farmacy Health and Nutritional Sciences, Rende, Italy; 524 529 Ghent University, Translational Nuclear Receptor Research, VIB Center for Medical Biotechnology, Department of Biomolecular Medicine, Ghent, Belgium; 525 530 “Sapienza” University of Rome, Department of Radiotherapy, Policlinico Umberto I, Rome, Italy; 526 531 University of Verona, Azienda Ospedaliera Universitaria Integrata-Verona, Department of Medicine, Verona; Italy; 527 532 Oswaldo Cruz Foundation, Oswaldo Cruz Institute, Leprosy Laboratory, Rio de Janeiro, Brazil; 528 533 University of Antwerp, Laboratory of Physiopharmacology, Antwerp, Belgium; 529 534 Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute, Stockholm, Sweden.; 530 535 Sapienza University of Rome, Ospedale Sant\'Andrea, Rome, Italy; 531 536 Università degli Studi di Milano, Department of Medical Biotechnology and Translational Medicine, Milano, Italy; 532 537 University of Urbino Carlo Bo, Department of Biomolecular Sciences, Unit of Pharmacology and Public Health, Urbino, Italy; 533 538 University of Fribourg, Department of Biology, Fribourg, Switzerland; 534 539 Danish Cancer Society Research Center, Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Copenhagen, Denmark; 535 540 University of California, San Francisco, Department of Pathology, San Francisco, CA, USA; 536 541 Washington University School of Medicine, Departments of Pediatrics and Cell Biology & Physiology, St. Louis, MO, USA; 537 542 KU Leuven, Department of Development and Regenaration, Laboratory of Pediatrics, PKD Research Group, Leuven, Belgium; 538 543 Boston University, Department of Biology, Boston, MA, USA; 539 544 IFOM, The FIRC Institute of Molecular Oncology, Milan, Italy; 540 545 University of Colorado Anschutz Medical Campus, Department of Biochemistry and Molecular Genetics, Aurora, CO, USA; 541 546 University of Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France; 542 547 Instituto de Fisiologia Celular, UNAM, Department of Biochemistry and Structural Biology, Mexico City, Mexico; 543 1586 Medical University of South Carolina, Charleston, SC 29425, USA; 544 549 University of Melbourne, School of Biomedical Sciences, Melbourne, Victoria, Australia; 545 550 University of Buenos Aires, Faculty of Pharmacy and Biochemistry, Institute of Immunology, Genetics and Metabolism (INIGEM), CONICET. Buenos Aires, Argentina; 546 551 L.N.C.I.B. Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie, AREA Science Park, Trieste, Italy; 547 552 University of Zagreb School of Medicine, Department of Physiology and Croatian Institute for Brain Research, Zagreb, Croatia; 548 553 Hospital for Sick Children, Program in Cell Biology Department, Toronto, Canada; University of Toronto, Department of Biochemistry, Toronto, Canada; 549 554 Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Medicinal Biotechnology, Beijing, China; 550 555 Virginia Commonwealth University, Department of Biochemistry and Molecular Biology, Richmond, VA, USA; 551 556 Centre for Cancer Biology, University of South Australia, Adelaide, Australia; 552 557 Division of Developmental Biology, National Institute of Child Health & Human Development, National Institutes of Health, Bethesda, MD, USA.; 553 558 University of North Carolina at Chapel Hill, Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA; 554 559 University of New Mexico Health Sciences Center, Autophagy, Inflamamtion and Metabolism (AIM) Center, Albuquerque, NM, USA; 555 560 Institut National de la Recherche Scientifique, Centre Armand-Frappier Santé Biotechnologie, Laval, QC, Canada; 556 561 Bellvitge Biomedical Research Institute-IDIBELL, Oncobell Program. L\'Hospitalet de Llobregat, Barcelona, Spain; 557 562 University of California, San Diego; Section of Cell and Developmental Biology, La Jolla, CA, USA; 558 563 University of Zurich, Institute of Physiology, Zurich, Switzerland; 559 564 Walter and Eliza Hall Institute of Medical Research, Ubiquitin Signalling Division, Melbourne, Australia; University of Melbourne, Department of Medical Biology, Melbourne, Australia; 560 58 Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, Italy;565 University of Naples “Federico II”, Department of Chemical, Materials and Industrial Production Engineering, Naples, Italy; 561 566 University of Perugia, Department of Chemistry, Biology and Biotechnology, Perugia, Italy; 562 567 Sapienza University of Rome, Department of Biochemical Sciences A. Rossi Fanelli, Rome, Italy; 563 568 Philipps University of Marburg, Department of Visceral, Thoracic and Vascular Surgery, Marburg, Germany; 564 569 IRCCS Foundation Ca\' Granda Ospedale Maggiore Policlinico, Dino Ferrari Center, Neuroscience Section, University of Milan, Department of Pathophysiology and Transplantation, Milan, Italy; 565 570 University of Teramo, Faculty of Veterinary Medicine, Teramo, Italy; 566 571 Western University, Department of Physiology and Pharmacology, London, ON, Canada; 567 572 Harvard Medical School, Boston Children’s Hospital, F.M. Kirby Neurobiology Center, Translational Neuroscience Center, Department of Neurology, Boston, MA, USA; 568 573 National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome, Italy; 569 574 National and Kapodistrian University of Athens, Department of Biology, Panepistimioupolis, Athens, Greece; 570 575 University of Cincinnati College of Medicine, Department of Cancer Biology, Cincinnati, OH, USA; 571 576 University of Chile, Faculty of Chemical and Pharmaceutical Sciences, Department of Chemical Pharmacology and Toxicology, Santiago de Chile, Chile; 572 577 University of Alcalá, Deparment of Systems Biology, Biochemistry and Molecular Biology, Alcalá de Henares, Madrid, Spain; 573 578 Arizona State University, Phoenix, AZ, USA; 574 579 Seoul National University, College of Pharmacy, Seoul, Korea; 575 580 University of Montreal, Faculty of Medicine, Microbiology, Infectious diseases and Immunology Department, CRCHUM, Montréal, QC, Canada; 576 581 Goethe University, Institute of Biochemistry II, Faculty of Medicine, Frankfurt am Main, Germany; 577 582 Zhejiang University, School of Medicine, Department of Cell Biology, Hangzhou, Zhejiang Province, China; 578 583 University of Kansas Medical Center, Department of Pharmacology, Toxicology and Therapeutics, Kansas City, KS, USA; 579 584 University of Rome La Sapienza, Department of Biology and Biotechnology C. Darwin, Rome, Italy; 580 585 University of Belgrade, Institute for Biological Research “Sinisa Stankovic” - National Institute of Republic of Serbia, Department of Neurobiology, Belgrade, Serbia; 581 586 University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Belgrade, Serbia; 582 587 Johns Hopkins University School of Medicine, Department of Pharmacology and Molecular Sciences and Department of Medicine, Baltimore, MD, USA;527 University of Dundee School of Medicine, Division of Cellular Medicine, Dundee, Scotland, UK; 583 588 Imperial College London, Department of Life Sciences and MRC Centre for Molecular Bacteriology and Infection, London, UK; 584 589 Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Department of Internal Medicine 3 - Rheumatology and Immunology, Erlangen, Germany; 585 590 Washington University School of Medicine and John Cochran VA Medical Center, Department of Medicine, St. Louis, MO, USA; 586 591 University of Manitoba, Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, Winnipeg, Manitoba, Canada; 587 592 Centre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Equipe 11 labellisée par la Ligue contre le Cancer, 75006 Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France; 588 593 University of Calgary, Department of Comparative Biology and Experimental Medicine, Calgary, AB, Canada; 589 594 University of Colima, University Center for Biomedical Research, Colima, Mexico.; 590 596 University of Canterbury, Biomolecular Interaction Centre, School of Biological Sciences, Christchurch, New Zealand; 591 597 Hacettepe University, Faculty of Medicine, Department of Medical Biology, Ankara, Turkey; 592 598 University of Kentucky, College of Medicine, Markey Cancer Center, Lexington, KY, USA; 593 599 University of Texas Southwestern Medical Center, Department of Internal Medicine, Center for Autophagy Research, Dallas, TX, USA; 594 600 Jinshan Branch of Shanghai Sixth People\'s Hospital, Department of Laboratory Medicine, Shanghai, China; 595 601 Washington University in St Louis School of Medicine, Department of Internal Medicine, St. Louis, MO, USA; 596 602 Goethe University, Institute of Biophysical Chemistry, Frankfurt, Germany; 597 603 Nanjing University, Medical School, Division of Immunology, Nanjing, Jiangsu, China; 598 604 Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA; 599 605 Umeå University, Department of Chemistry, Umeå, Sweden; 600 606 University of Arkansas, Center of Excellence for Poultry Science, Fayetteville, AR, USA; 601 607 Oncogenetic Laboratory, Meir Medical Center, Kfar Saba, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; 602 608 Tongren Hospital, Shanghai Jiaotong University School of Medicine, Department of Neurology, Shanghai, China; 603 609 University of British Columbia, Department of Urologic Sciences, Vancouver, BC, Canada; 604 612 National Institute of Biological Sciences, Beijing, China; 605 613 Central South University, The Second Xiangya Hospital, Department of Nephrology, Changsha , Hunan, China; 606 614 Chinese Academy of Medical Sciences and Peking Union Medical College, Institute of Blood Transfusion, Chengdu, China; 607 320 University of Coimbra, Faculty of Medicine and CNC-Center for Neuroscience and Cell Biology, Coimbra, Portugal;615 CNC - Center for Neuroscience and Cell Biology, Coimbra, IIIUC - Instituto de Investigação Interdisciplinar, University of Coimbra, Coimbra, Portugal; 608 476 OncoRay National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany; Helmholtz-Zentrum Dresden - Rossendorf, Institute of Radiooncology - OncoRay, Dresden, Germany; German Cancer Consortium (DKTK), Partner site Dresden, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany; 609 616 Cardiff University, Division of Cancer and Genetics, Heath Park, Cardiff, UK; 610 617 Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, Universidad Pablo de Olavide, Seville, Spain; 611 618 Shanghai Proton and Heavy Ion Center, Department of Research & Development, Pudong, Shanghai, China; 612 619 University Medical Center Hamburg-Eppendorf, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hamburg, Germany;2313 A.V. Zhirmunsky National Scientific Center of Marine Biology, Laboratory of Pharmacology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russian Federation;2314 Far Eastern Federal University, School of Natural Sciences, Vladivostok, Russian Federation; 613 620 Department of Neurology, Boston Children’s Hospital, Boston, MA, USA; 614 621 Medical University of Vienna, Department of Dermatology, Division for Biology and Pathobiology of the Skin, Vienna, Austria; 615 622 University of Colorado Anschutz Medical Campus, Division of Renal diseases, Aurora, CO, USA; 616 623 University of Manitoba, Department of Physiology and Pathophysiology, Regenerative Medicine Program, Winnipeg, Manitoba, Canada; 617 624 University of Cologne, Centre for Biochemistry, Institute of Biochemistry I, Medical Faculty, Cologne, Germany; 618 625 United Arab Emirates University, College of Medicine & Health Sciences, Department of Anatomy, Al Ain, UAE; 619 626 University of Graz, NAWI Graz, Institute of Molecular Biosciences, Graz, Austria; BioTechMed Graz, Graz, Austria; University of Graz, Field of Excellence BioHealth, Graz, Austria; 620 627 Long Beach VA and University of California, Irvine, Irvine, CA, USA; 621 628 Ain Shams University, Faculty of Medicine, Department of Medical Biochemistry and Molecular Biology, Cairo, Egypt; 622 629 Hospital Universitari de Tarragona Joan XXIII, Institut d’Investigació Santitària Pere Virgili; 623 630 University of Illinois at Chicago, Department of Pathology, College of Medicine, Chicago, IL, USA; 624 631 Florida International University, Department of Immunology and Nano-Medicine, Miami, FL, USA; 625 632 Children’s Cancer Hospital Egypt 57357, Tumor Biology Research Program, Cairo, Egypt; 626 633 University of Camerino, Department of Biosciences and Biotechnology, Camerino, Italy; 627 634 Damietta University, Faculty of Science, Biochemistry Department, Damietta, Egypt; 628 635 Technische Universität Dresden, Medical Clinic I, University Hospital Carl Gustav Carus, Dresden, Germany; Technische Universität Dresden, Faculty of Medicine, Institute for Clinical Chemistry and Laboratory Medicine, Dresden, Germany; Institute of Molecular Genetics of the ASCR, Department of Cancer Cell Biology, Prague, Czech Republic; 629 636 Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Universidad de Buenos Aires-CONICET, Argentina; 630 637 University of Sheffield, The Bateson Centre, Department of Infection, Immunity and Cardiovascular Disease,Sheffield, South Yorkshire, UK; 631 638 Philipps University of Marburg, Department of Cytobiology and Cytopathology, Marburg, Germany; 632 639 Sanford Burnham Prebys Medical Discovery Research Institute, La Jolla, CA, USA; 633 640 Bogazici University, Department of Molecular Biology and Genetics, Bebek, Istanbul, Turkey; 634 641 Pfizer, Oncology Research & Development, Pearl River, NY, USA; 635 642 Oslo University Hospital, Institute for Cancer Research, Department of Tumor Biology, Montebello, Oslo, Norway; 636 643 University of Bergen, Department of Biomedicine/ Centre for Cancer Biomarkers (CCBIO), Bergen, Norway; 637 427 The Norwegian Radium Hospital, Institute for Cancer Research, Department of Molecular Cell Biology, Montebello, Oslo, Norway; University of Oslo, Faculty of Mathematics and Natural Sciences, The Department of Biosciences, Oslo, Norway; 638 644 Instituto de Investigaciones Biomédicas Alberto Sols, C.S.I.C./U.A.M., Madrid, Spain; 639 646 Universität zu Köln, CECAD Forschungszentrum, Institut für Genetik, Köln, Germany; 640 647 University of Turku, Institute of Biomedicine, Turku, Finland; 641 648 IRIM, University of Montpellier, CNRS, Montpellier, France; 642 649 Medical University of Lodz, Department of Laboratory Diagnostics, Lodz, Poland; 643 650 Sapienza University of Rome, DAHFMO-Section of Anatomy, Rome, Italy; 644 651 Istituto Superiore di Sanità, Department of Oncology and Molecular Medicine, Rome, Italy; 645 652 Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden; 646 653 Universidad Nacional de Cuyo, Facultad de Ciencias Médicas, Laboratorio de Biología Celular y Molecular, IHEM-CONICET, Mendoza, Argentina; 647 654 Max-Planck-Institute of Biophysical Chemistry, Biochemistry of Signal Dynamics, Göttingen, Germany; 648 655 La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia; 649 656 Universidad Miguel Hernández (UMH), Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE), Elche, Spain; 650 657 Dresden University Medical Center, Department of Neurology, Dresden, Germany; 651 658 University of South Carolina School of Medicine, Department of Cell Biology and Anatomy, Columbia, SC, USA; 652 659 University of Pittsburgh, Department of Surgery, Pittsburgh, PA, USA; 653 660 University of Cincinnati, Department of Cancer Biology, Cincinnati, OH, USA; 654 661 University of Oslo and Akershus University Hospital, Department of Clinical Molecular Biology, Lørenskog, Norway; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway; 655 662 Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Interdisciplinary Research Center on Biology and Chemistry, Shanghai, China; University of Chinese Academy of Sciences, Beijing, China; 656 663 The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; 657 664 King’s College London, Department of Basic and Clinical Neuroscience, London, United Kingdom; Institut du Cerveau et de la Moelle épinière (ICM), Paris, France; 658 665 Centre International de Recherche en Infectiologie (CIRI), University Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS Lyon, Lyon, France; 659 666 Rudolf Virchow Center, University of Würzburg, Würzburg, Germany; 660 667 South Australian Health and Medical Research Institute, Hopwood Centre for Neurobiology, Lifelong Health Theme, Adelaide, South Australia, Australia; 661 668 Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA; 662 669 Guangzhou Medical University, School of Basic Medical Sciences, State Key Laboratory of Respiratory Disease, Guangzhou, China; 663 670 The First Hospital of Jilin University, Department of Neurology, Changchun, China; 664 671 Medical School of Zhejiang University, Sir Run Run Shaw Hospital, Key lab of Biotherapy in Zhejiang, Laboratory of Cancer Biology, Hangzhou, China; 665 672 The University of Hong Kong, School of Chinese Medicine, Li Ka Shing Faculty of Medicine, Hong Kong, China; 666 673 Baylor College of Medicine, Department of Biochemistry and Molecular Biology, Houston TX, USA; 667 674 Chinese Academy of Sciences, Institute of Biophysics, Beijing, China; 668 675 University of São Paulo (USP), Ribeirão Preto Medical School, Department of Genetics, Ribeirão Preto, SP, Brazil.; 669 676 Washington University in St. Louis, Department of Ophthalmology and Visual Sciences, St. Louis, MO, USA; 670 677 University of Texas Southwestern Medical Center, Center for Autophagy Research, Department of Internal Medicine and Howard Hughes Medical Institute, Dallas, TX, USA; 671 678 Institute of Biomedical Research of Barcelona (IIBB)-CSIC, Barcelona, Spain; Liver Unit, Hospital Clinic i Provincial de Barcelona, IDIBAPS and CIBEREHD, Barcelona, Spain; Research Center for ALPD, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; 672 679 Columbia University, New York, NY, USA; 673 680 Università del Piemonte Orientale, Department of Health Sciences, Laboratory of Molecular Pathology, Novara, Italy; 674 681 University of Sao Paulo, Institute of Biosciences, Sao Paulo, SP, Brazil; 675 490 University of California, San Diego, Department of Cellular and Molecular Medicine, La Jolla, CA, USA; 676 683 Instituto de Investigaciones Marinas CSIC, Department of Biotechnology and Aquaculture, Immunology and Genomics, Vigo, Spain; 677 684 University of Padua, Department of Biomedical Sciences, Padua, Italy; Italian National Research Council (CNR), Neuroscience Institute, Padua, Italy; 678 685 University of Piemonte Orientale, Department of Translational Medicine, Novara, Italy; 679 686 Universidade Federal do Rio Grande do Sul (UFRGS), Morphological Sciences Department, Porto Alegre, RS, Brazil; Clinicas Hospital of Porto Alegre, Porto Alegre, RS, Brazil; 680 687 Danish Cancer Society Research Center, Redox Signaling and Oxidative Stress Group, Copenhagen, Denmark; 681 573 National Institute for Infectious Diseases “L. Spallanzani” IRCCS, Rome, Italy;688 Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; 682 689 Università degli Studi Sapienza di Roma, SAIMLAL Department, Roma, Italy; 683 690 Center for Systems and Therapeutics, Gladstone Institutes; Departments of Neurology and Physiology, University of California San Francisco, San Francisco, CA, USA; 684 691 NYU School of Medicine, Department of Medicine, New York, NY, USA; 685 692 Virginia Commonwealth University, School of Medicine, Department of Human and Molecular Genetics, Richmond, VA, USA; Virginia Commonwealth University, VCU Institute of Molecular Medicine, Richmond, VA, USA; Columbia University, College of Physicians and Surgeons, Departments of Pathology, Neurosurgery and Urology, New York, NY, USA; 686 693 State University of New York, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Departments of Ophthalmology/Biochemistry and Neuroscience Program, Buffalo, NY, USA; 687 694 Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Centre for Molecular Inflammation Research, Trondheim, Norway; 688 695 Central University of Tamil Nadu, Thiruvarur, Tamil Nadu, India; 689 696 Babraham Institute, Signalling ISP, Cambridge, UK; 690 697 University of Genova, Department of Internal Medicine and IRCCS Policlinico San Martino, Genova, Italy; 691 698 Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada; 692 699 University of Pavia, Department of Molecular Medicine, Biochemistry Unit, Pavia, Italy; 693 700 University of Pisa, Department of Translational Medicine and New Technologies in Medicine and Surgery, Pisa, Italy; I.R.C.C.S. Neuromed Pozzilli, Pozzilli, Italy; 694 701 Istituto Superiore di Sanità, Department of Environment and Health, Section of Mechanisms, Biomarkers and Models, Rome, Italy; 695 702 University of Texas Medical Branch, Mitchell Center for Neurodegenerative Diseases, Department of Neurology, Galveston, TX, USA; 696 703 University of Nebraska-Lincoln, Redox Biology Center, Lincoln, NE, USA; 697 704 Laboratory of Sex-gender Medicine, National Institute of Biostructures and Biosystems, Sassari, Italy; 698 705 Icahn School of Medicine at Mount Sinai, Department of Medicine, Division of Liver Diseases, New York, NY, USA; 699 706 Institute of Science and Technology Austria (IST), Klosterneuburg, Austria; 700 707 Clínica Universidad de Navarra, Metabolic Research Laboratory, CIBEROBN, IdiSNA, Pamplona, Spain; 701 708 University of Extremadura, Centro de Investigación Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Investigación Biosanitaria de Extremadura (INUBE), Department of Biochemistry, Molecular Biology and Genetics, Faculty of Nursing and Occupational Therapy, Cáceres, Spain; 702 709 Kyushu University, Medical Institute of Bioregulation, Fukuoka, Japan; 703 710 Tokyo Institute of Technology, Institute of Innovative Research, Cell Biology Center, Yokohama, Japan; 704 470 National Institute of Neuroscience, National Center of Neurology and Psychiatry, Department of Degenerative Neurological Diseases, Kodaira, Tokyo, Japan; 705 711 Tohoku University, Graduate School of Life Sciences, Department of Integrative Life Sciences, Sendai, Miyagi, Japan; 706 712 Goethe-University Frankfurt, Institute for Experimental Cancer Research in Pediatrics, Frankfurt, Germany; 707 713 Monash University, Cancer Program, Biomedicine Discovery Institute and Department of Anatomy & Developmental Biology, VIC, Australia; Peter MacCallum Cancer Centre, Prostate Cancer Translational Research Laboratory, Melbourne, Victoria, Australia; University of Melbourne, Sir Peter MacCallum Department of Oncology, Parkville, VIC, Australia; 708 714 Juntendo University Graduate School of Medicine, Department of Neurology, Bunkyo-ku, Tokyo Japan; 709 715 The University of Chicago, Department of Microbiology, Chicago, IL, USA; 710 716 University of Gdansk, Department of Molecular Biology, Gdansk, Poland; 711 717 New York University - Abu Dhabi, Saadiyat Island Campus, Division of Science (Biology), Cell Death Signaling Laboratory, Abu Dhabi, UAE; 712 718 University of Oxford, Sir William Dunn School of Pathology, Oxford, UK; 713 719 Universidad Castilla La Mancha, Facultad de Farmacia, Área Tecnología Farmacéutica, Albacete, Spain; 714 720 Beckman Research Institute at City of Hope, Department of Systems Biology, Monrovia, CA, USA; 715 721 Weill Cornell Medical College, Department of Radiation Oncology, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA; Yale School of Medicine, Department of Dermatology, New Haven, CT, USA; Université de Paris, Paris, France; 716 722 Sorbonne Université, Developmental Biology Laboratory, CNRS, Institut de Biologie Paris Seine, IBPS, UMR7622, Paris, France; 717 723 University of Edinburgh, Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, Edinburgh, UK; 718 724 University of Texas MD Anderson Cancer Center, Department of Experimental Radiation Oncology, Houston, TX, USA; 719 725 MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, UK; 720 726 Fourth Military Medical University, School of Aerospace Medicine, Xi\'an, China; 721 727 Chinese Academy of Sciences, Institute of Zoology, State Key Laboratory of Stem cell and Reproductive Biology, Beijing, China; 722 728 Harbin Institute of Technology, the HIT Center for Life Sciences, School of Life Sciences and Technology, Harbin, China; 723 729 South China University of Technology, School of Medicine and Institute for Life Sciences, GuangZhou, China; 724 730 University of Pittsburgh School of Medicine, Hillman Cancer Center and Department of Microbiology and Molecular Genetics, Pittsburgh, PA, USA; 725 731 University of Pittsburgh School of Medicine, Department of Surgery, Pittsburgh, PA, USA; 726 732 Chinese Academy of Sciences Center for Excellence in Molecular and Cellular Sciences, Shanghai Institute of Biochemistry and Cell Biology, Shanghai, China; 727 733 Universitat de Lleida, Department of Experimental Medicine, IRBLleida, Lleida, Spain; 728 734 Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología, Cátedra de Inmunología, Buenos Aires, Argentina; Universidad de Buenos Aires, CONICET, Instituto de Estudios de la Inmunidad Humoral (IDEHU), Buenos Aires, Argentina; 729 735 Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Buenos Aires, Argentina; 730 736 National Center for Biotechnology (CNB)-CSIC, Laboratory of Intracellular Bacterial Pathogens, Madrid, Spain; 731 737 Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Anatomía, Histología y Neurociencia, Madrid, Spain; 732 738 Universidad Autonoma de Nuevo Leon, School of Medicine, Department of Histology, Monterrey, Nuevo Leon, Mexico; 733 739 Universidad de Salamanca, Institute of Functional Biology and Genomics (IBFG), Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; 734 740 Department of Cell Biology and Histology, Faculty of Biology, University of Murcia, IMIB-Arrixaca, Murcia, Spain; 735 741 Department of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB- CSIC); Liver Unit, Hospital Clinic i Provincial de Barcelona, IDIBAPS, CIBEREHD, Barcelona, Spain; 736 742 Cajal Institute/CSIC and CIBERNED, ISCIII, Madrid, Spain; 737 743 KU Leuven, Department of Cellular and Molecular Medicine, Leuven, Belgium; 738 744 Centro de Biología Molecular (Severo Ochoa) (CSIC-UAM), Madrid, Spain; 739 745 Sapienza University of Rome, Department of Experimental Medicine, Rome, Italy; 740 746 Tulane University, Department of Microbiology and Immunology, New Orleans, LA, USA; 741 747 University of Bonn, Clinical Centre, Department of Psychiatry, Neurohomeostasis Group, Bonn, Germany; 742 748 Zhejiang University School of Medicine,Women\'s Hospital,Hangzhou, Zhejiang, China; 743 749 University of Milano, Department of Biomedical Sciences for Health, Milan, Italy; 744 750 Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2357, Conventionné avec l\'Université de Strasbourg, Strasbourg, France; 745 751 University Clinic Freiburg, Institute for Microbiology and Hygiene, University of Freiburg - Faculty of Medicine, Freiburg, Germany; 746 752 Mortimer B. Zuckerman Mind Brain and Behavior Institute, Columbia University, New York, NY, USA; 747 753 Institute for Animal Developmental and Molecular Biology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany; 748 754 Virginia Commonwealth University, Departments of Pharmacology, Toxicology and Medicine and Massey Cancer Center, Richmond, VA, USA; 749 755 Kerman University of Medical Sciences, Institute of Neuropharmacology, Neuroscience Research Center, Kerman, Iran; 750 44 Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada;1422 Autophagy Research Center, Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran; 751 756 University of Torino, Department of Molecular Biotechnology and Health Sciences, Torino, Italy; 752 757 KU Leuven, Department of Public Health and Primary Care, Centre Environment & Health, Leuven, Belgium; 753 758 University of Sussex, School of Life Sciences, Department of Biochemistry and Biomedicine, Brighton, UK; 754 759 Sapienza University of Rome, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Rome, Italy; 755 760 Democritus University of Thrace, Medical School, Department of Pathology, Alexandroupolis, Greece; 756 761 Weill Cornell Medicine, Brain and Mind Research Institute, Burke Neurological Institute, White Plains, NY, USA; 757 762 University of Manitoba, Departments of Biochemistry and Medical Genetics, Winnipeg, Canada; 758 763 Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland;1566 Clinic of Neonatology, Department of Women, Mother and Child, University Hospital Center of Vaud (CHUV), Lausanne, Switzerland; 759 764 National Institutes of Health, National Institutes of Neurological Disorders and Stroke (NINDS), Bethesda, MD, USA; 760 765 University of Ferrara, Department of Morphology, Surgery and Experimental Medicine, Ferrara, Italy; 761 766 University of Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Coimbra, Portugal; University of Coimbra, Center for Innovative Biomedicine and Biotechnology, Coimbra, Portugal; 762 767 University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, Ontario, Canada; 763 769 University of California, Davis and MIND Institute, School of Veterinary Medicine, Dept. Molecular Biosciences, Davis, CA, USA; 764 770 INSERM, UMR1037 CRCT, Toulouse, France; Université Toulouse III-Paul Sabatier, UMR1037 CRCT, Toulouse, France; CNRS, ERL5294 CRCT, Toulouse, France; 765 771 University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute for Medical Microbiology, Immunology and Hygiene, Cologne, Germany; 766 772 University of Seville, Department of Genetics, Seville, Spain; 767 773 Ludwig Institute for Cancer Research; University of California San Diego, Department of Cellular and Molecular Medicine, La Jolla, CA, USA; 768 774 Medical University of Warsaw, Department of Immunology, Warsaw, Poland; 769 775 University of Auckland, School of Biological Sciences, Auckland, New Zealand; 770 776 Luxembourg Institute of Health, Department of Oncology, NorLux Neuro-Oncology Laboratory, Luxembourg, Luxembourg; 771 777 Center of Toxins, Immune-response and Cell Signaling (CeTICS) and Laboratório Especial de Ciclo Celular (LECC), Instituto Butantan, São Paulo, Brazil; 772 778 University of Groningen, University Medical Center of Groningen, Department of Biomedical Sciences of Cells and Systems, Groningen, The Netherlands; 773 779 Leiden University Medical Center, Department of Cell and Chemical Biology and Oncode Institute, Leiden, The Netherlands; 774 245 Albert Einstein College of Medicine, Department of Developmental and Molecular Biology, Bronx, NY, USA;248 Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain; 775 780 Shanghai Jiao Tong University, School of Life Sciences and Biotechnology, Shanghai, China; 776 781 University of León, Institute of Biomedicine (IBIOMED) and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), León, Spain; 777 782 University of La Laguna, Institute of Biomedical Technologies, Department of Basic Medical Sciences, La Laguna, Tenerife, Spain; 778 783 University of Alberta, Department of Biochemistry, Edmonton, Alberta, Canada; 779 784 University of Alabama at Birmingham, Department of Optometry and Vision Science, Birmingham, AL, USA; 780 785 The Henry M. Jackson Foundation, Inc. Bethesda, MD, USA; 781 786 Technische Universität München, Klinikum rechts der Isar, Comprehensive Cancer Center München, München, Germany; 782 787 Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Química Biológica Ciencias Exactas y Naturales (IQUIBICEN), Facultad de Ciencias Exactas y Naturales, Departamento de Química Biológica, Laboratorio de Disfunción Celular en Enfermedades Neurodegenerativas y Nanomedicina, Buenos Aires, Argentina; 783 788 BC Cancer, Michael Smith Genome Sciences Centre, Vancouver, BC, Canada; 784 789 Harvard Medical School, Department of Dermatology, Cutaneous Biology Research Center Massachusetts General Hospital, Boston, MA, USA; 785 790 Consejo Superior de Investigaciones Científicas, Instituto de Bioquímica Vegetal y Fotosíntesis (CSIC-IBVF), Sevilla, Spain; 786 791 Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; 787 792 Tel Aviv University, Sackler Faculty of Medicine and Sagol School of Neuroscience, Department of Human Molecular Genetics and Biochemistry, Tel Aviv, Israel; 788 793 Max Planck Institute for Biology of Ageing, Cologne, Germany; University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; 789 794 Jena University Hospital, Department of Anesthesiology and Intensive Care Medicine, Center for Molecular Biomedicine (CMB) and Center for Sepsis Control and Care (CSCC), Jena, Germany; 790 795 Weill Cornell Medicine, Feil Family Brain and Mind Research Institute, New York, NY, USA; 791 797 University of Texas MD Anderson Cancer Center, Department of Cancer Systems Imaging, Houston, TX, USA; 792 798 University of the West of England, Department of Applied Sciences, Bristol, UK; 793 799 Flinders University, College of Medicine and Public Health, Adelaide, Australia; 794 800 University of Alabama at Birmingham,Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, Birmingham, AL, USA; 795 801 Boston University, Departments of Biomedical Engineering, Chemistry, and Medicine, Boston, MA, USA; 796 802 Université de Strasbourg/CNRS UPR 3572 Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France; 797 803 University of Iowa, Departments of Pediatrics and Microbiology, Iowa City, IA, USA; 798 804 Max Planck Institute for Biology of Ageing, Cologne, Germany; 799 805 German Institute of Human Nutrition, Department of Molecular Toxicology, Nuthetal, Germany; 800 806 Lanzhou University, School of Public Health, Lanzhou, Gansu, China; 801 808 Case Western Reserve University, Comprehensive Cancer Center, Cleveland, OH, USA; 802 809 University of Salento, Department of Biological and Environmental Sciences and Technologies, Lecce, Italy; 803 810 Research Center Principe Felipe, Cellular Pathology Laboratory, Valencia, Spain; 804 811 Johns Hopkins University School of Medicine, Department of Neuroscience, Baltimore, MD, USA; 805 812 School of Pharmacy, Complutense University, Madrid, Spain; Centro de Investigación Biomédica en Red (CIBER) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain; 806 813 Dalhousie University, Faculty of Medicine, Departments of Pathology, Biology, and Microbiology & Immunology, Halifax, NS, Canada; 807 814 David Geffen School of Medicine at UCLA, Department of Medicine, Los Angeles, CA, USA; 808 815 KU Leuven, Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, Leuven, Belgium; 809 816 Justus-Liebig University, Department of Internal Medicine, Giessen, Germany; 810 817 Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME, USA; 811 818 Tongji University School of Medicine, Shanghai Tenth People’s Hospital, Department of Gastroenterology, Shanghai, China; 812 819 The University of Sheffield, Department of Biomedical Science, Firth Court, Western Bank, Sheffield, UK; 813 820 University of Virginia, School of Medicine, Department of Surgery, Charlottesville, VA, USA; 814 821 University of California, Los Angeles, Department of Neurology, Molecular and Medical Pharmacology, David Geffen School of Medicine, Los Angeles, CA, USA; 815 822 Institute of Microbial Technology, Department of Molecular Biology, Chandigarh, India; 816 823 CSIR-Central Drug Research Institute, Lucknow, India; 817 824 University of Oslo, Institute of Basic Medical Sciences, Oslo, Norway; 818 825 Deakin University, School of Medicine, Faculty of Health, Victoria, Australia; 819 916 Macquarie University, Faculty of Medicine, Health and Human Sciences, New South Wales, Australia; 820 827 University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla, CA, USA; 821 828 Medical College of Wisconsin, Department of Medicine and Cardiovascular Center, Milwaukee, WI, USA; 822 829 ICAR-Indian Veterinary Research Institute, FMD VP Laboratory, Bengaluru, India; 823 830 University of Eastern Finland, A.I. Virtanen Institute for Molecular Sciences, Kuopio, Finland; 824 831 Brandeis University, Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Waltham, MA, USA; 825 832 University of Gdansk, Department of Medical Biology and Genetics, Gdansk, Poland; 826 833 Tokai University School of Medicine, Department of Molecular Life Sciences, Isehara, Kanagawa, Japan; 827 834 Swedish Agricultural University (SLU), Department of Plant Biology, Uppsala, Sweden; 828 835 Hasselt University, Biomedical Research Institute, Diepenbeek, Belgium; 829 836 University of Surrey, School of Bioscience and Medicine, Department of Microbial Sciences, Stag Hill Campus, Guildford, Surrey, UK; 830 837 Barts Cancer Institute, Queen Mary University of London, Centre for Biotherapeutics and Biomarkers, London, UK; 831 838 Johns Hopkins University Bloomberg School of Public Health, W. Harry Feinstone Department of Molecular Microbiology and Immunology, Baltimore, MD, USA; 832 839 Goethe University, Institute for Molecular Biosciences, Frankfurt/Main, Germany; 833 840 Osaka University, Graduate School of Medicine, Department of Genetics, Suita, Osaka, Japan; 834 841 Zhejiang University, Sir Run Run Shaw Hospital, College of Medicine, Department of Medical Oncology, Zhejiang, Hangzhou, China; 835 842 Sanford Burnham Prebys Medical Discovery Institute, Program of Development, Aging and Regeneration, La Jolla, CA, USA; 836 843 University of Michigan, Department of Biological Chemistry, Ann Arbor, MI, USA; 837 844 Third Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan; 838 845 Department of Neurophysiology, Institute for Biological Research “Siniša Stanković” – National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia; 839 846 University of California, Davis, School of Medicine, Department of Pharmacology, Davis, CA, USA; 840 847 University of Toronto, Department of Medicine, Toronto, Ontario, Canada; 841 848 Monash University, School of Clinical Sciences at Monash Health, Centre for Inflammatory Diseases, Rheumatology Group, Clayton, Victoria, Australia; 842 849 Tohoku University Graduate School of Medicine, Division of Neurology, Department of Neuroscience & Sensory Organs, Sendai, Japan; 843 850 University of Malaya, Institute of Biological Sciences (Genetics), Kuala Lumpur, Malaysia; 844 851 Washington University School of Medicine, Division of Pulmonary and Critical Care Medicine, St. Louis, MO, USA.; 845 852 Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP), Department of Molecular Pharmacology and Cell Biology, Berlin, Germany; 846 853 California Institute of Technology, Division of Biology and Biological Engineering, Pasadena, CA, USA; 847 854 University of Massachusetts Medical School, Molecular, Cell and Cancer Biology, Worcester, MA, USA; 848 855 Bulgarian Academy of Sciences, Institute of Biology and Immunology of Reproduction (Acad. Kiril Bratanov), Sofia, Bulgaria; 849 856 University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, MN, USA; 850 857 Northwestern University, Feinberg School of Medicine, Department of Cell and Developmental Biology, Chicago, IL, USA; 851 858 Sichuan University, West China School of Pharmacy, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Chengdu, China; 852 859 Jinan University, College of Pharmacy, Guangzhou, China; 853 860 Department of Immunology, Duke University Medical Center, Durham, NC, USA; 854 861 University of Chicago, Department of Medicine, Section of Dermatology, Chicago, IL, USA; 855 862 D\'Youville College, School of Pharmacy, Department of Pharmaceutical, Social and Administrative Sciences, Buffalo, NY, USA; 856 863 University of Innsbruck, Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, Innsbruck, Austria; University Medical Center Groningen, University of Groningen, Section Systems Medicine of Metabolism and Signaling, Laboratory of Pediatrics, Groningen, The Netherlands; 857 864 National Institutes of Health, National Eye Institute, Ophthalmic Genetics and Visual Function Branch, Ophthalmic Molecular Genetics Section, Bethesda, MD, USA; 858 865 University of Glasgow, Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, Glasgow, UK; 859 866 University College London, Cancer Institute, London, UK; 860 867 Universidade Federal de São Carlos, Department of Genetics and Evolution, São Carlos (SP), Brazil; 861 868 Instituto de Investigación Sanitaria de Navarra (IdISNA), Fundación Miguel Servet, Biomedical Research Center of Navarre-Navarrabiomed, Immunomodulation Group, Pamplona, Spain; 862 869 Université de Bordeaux, Institut des Maladies Neurodégénératives (IMN), CNRS UMR 5293, Bordeaux, France; 863 870 University of Barcelona, Barcelona Hepatic Hemodynamic Unit, Liver Unit, Hospital Clinic, Hospital Clínic-Institut d’Investigacions Biomèdiques (IDIBAPS), Centro de Investigación Biomédica Red de enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain; 864 871 INRA, UR1037 Laboratory of Fish Physiology and Genomics, Campus de Beaulieu, Rennes, France; Hunan Normal University, College of Life Sciences, State Key Laboratory of Developmental Biology of Freshwater Fish, Changsha, Hunan, China; 865 872 University of Lleida, Department of Basic Medical Sciences, IRBLleida, Lleida, Spain; 866 47 The Francis Crick Institute, Molecular Cell Biology of Autophagy, London, UK;873 Universidad del País Vasco, Instituto Biofisika (CSIC, UPV/EHU) and Departamento de Bioquímica y Biología Molecular, Bilbao, Spain; 867 874 Centenary Institute, The University of Sydney, Newtown, New South Wales, Australia; Faculty of Medicine and Health, The University of Sydney, Newtown, New South Wales, Australia; 868 875 University of Chile, Biomedical Neuroscience Institute, Faculty of Medicine, Santiago, Chile; FONDAP Center for Geroscience Brain Health and Metabolism, Santiago, Chile; University of Chile, Institute of Biomedical Science, Program of Cellular and Molecular Biology, Santiago, Chile; Buck Institute for Research on Aging, Novato, CA, USA; 869 876 University of Bern, Institute of Cell Biology, Bern, Switzerland; 870 877 Kyushu University, Depatment of Bioscience and Biotechnology, Nishi-ku, Fukuoka, Japan; 871 878 UT Southwestern Medical Center, Departments of Medicine (Cardiology) and Molecular Biology, Dallas, TX, USA; 872 879 Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA; 873 880 University of Waterloo, School of Pharmacy, Kitchener, ON, Canada; 874 881 University of Hong Kong, Department of Medicine, Division of Neurology, Pokfulam, Hong Kong, China; 875 882 National University of Singapore, Department of Physiology, Singapore; 876 883 University of North Carolina at Chapel Hill, Department of Pharmacology, Chapel Hill, NC, USA; 877 884 Yale University, Department of Molecular Biophysics and Biochemistry, New Haven, CT, USA; 878 885 Swedish University of Agricultural Sciences (SLU) and Linnean Center for Plant Biology, Uppsala BioCenter, Department of Plant Biology, Uppsala, Sweden; 879 886 University Côte d\'Azur, FHU OncoAge, Department of Pathology, Nice, France; 880 887 German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Department of Molecular Toxicology, Nuthetal, Germany; 881 888 University of Helsinki, Medicum, Biochemistry and Developmental Biology, Helsinki, Finland; 882 889 University of Birmingham, College of Medical and Dental Sciences, Institute of Inflammation and Ageing, Birmingham, UK; 883 890 Kyungpook National University, School of Medicine, Department of Physiology, Daegu, Korea; 884 891 Kaohsiung Medical University, Graduate Institute of Medicine & Department of Biochemistry, Faculty of Medicine, College of Medicine, Kaohsiung, Taiwan; 885 892 University of Cologne, Institute for Genetics and CECAD Research Center, Cologne, Germany; 886 893 European Molecular Biology Laboratory, Heidelberg, Germany; 887 894 University of Texas Southwestern Medical Center, Department of Internal Medicine, Dallas, TX, USA; 888 895 Chung Shan Medical University, Institute of Medicine, Taiwan; 889 896 National Chiao-Tung University, Department of Applied Chemistry and Institute of Molecular Science, Hsinchu, Taiwan; 890 897 University of Plymouth, Faculty of Health: Medicine, Dentistry and Human Sciences, Peninsula Dental School, Plymouth, Devon, UK; 891 898 Anhui University of Science and Technology, Department of Medical Immunology, Huainan, China; 892 899 Soochow University, Institute of Neuroscience, Suzhou, Jiangsu Province, China; 893 900 University of Texas Southwestern Medical Center, Department of Internal Medicine, Charles and Jane Center for Mineral Metabolism and Clinical Research, Dallas, TX, USA; 894 901 Southern Medical University, Shenzhen Hospital, Department of Gastroenterology, Shenzhen, Guangdong; 895 902 National Tsing Hua University, Department of Chemical Engineering, and Frontier Research Center on Fundamental and Applied Sciences of Matters, Hsinchu, Taiwan; 896 903 Northwest A&F University, College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering & Technology, Yangling, Shaanxi, China; 897 904 Shanghai Jiao Tong University School of Medicine, Shanghai General Hospital, Department of Orthopedics, Shanghai, China; Shanghai Bone Tumor Institution, Shanghai, China; 898 905 State University of New York, Downstate Health Sciences University, Department of Surgery and Cell Biology, Brooklyn, NY, USA; 899 906 Sichuan University, and Collaborative Innovation Center for Biotherapy, West China Hospital, West China School of Basic Medical Sciences & Forensic Medicine, and State Key Laboratory of Biotherapy and Cancer Center, Chengdu, China; 900 907 New York University School of Medicine, Department of Environmental Medicine, Urology, Biochemistry and Molecular Pharmacology, New York, NY, USA; 901 908 Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology & Department of Immunology and Microbiology, Shanghai, China; 902 909 University of Sydney, Kolling Institute, Renal Research Lab, Sydney, New South Wales, Australia; 903 910 Wenzhou Medical University, School of Laboratory Medicine and Life Sciences, Wenzhou, Zhejiang Province, China; 904 911 Huazhong University of Science and Technology, Tongji Medical College, School of Pharmacy, Wuhan, Hubei, China; 905 912 Chongqing University, School of Medicine, Center for Neurointelligence, Chongqing, China; 906 913 The Second Affiliated Hospital of Xi\'an Jiaotong University, Department of Radiation Oncology, Xi\'an, Shaan Xi, China; 907 914 Zhejiang University School of Medicine, The First Affiliated Hospital, Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, Zhejiang, China; 908 915 III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; 909 1010 Medical University of Vienna, Department of Pathology, Vienna, Austria; 910 917 University Hospital Jena, Institute of Human Genetics, Jena, Thuringia, Germany; 911 918 University of Otago, School of Biomedical Sciences and Brain Health Research Centre, Department of Biochemistry, Dunedin, New Zealand; 912 919 University of Bern, Institute of Pathology, Bern, Switzerland; TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge, COST Action CA15138; 913 920 Max Planck Institute of Biophysics, Department of Theoretical Biophysics, Frankfurt am Main, Germany; 914 921 University of California, Berkeley, Department of Molecular and Cell Biology, Berkeley, CA, USA; 915 922 West Virginia University, School of Medicine, Department of Physiology and Pharmacology, Morgantown, WV, USA; 916 923 Durham University, Department of Biosciences, Durham, UK; 917 924 University of Indonesia, Faculty of Medicine, Department of Obstetric and Gynecology, Jakarta, Indonesia; 918 925 Yonsei University, Department of Biotechnology, Seodaemun-gu, Seoul, Korea; 919 926 The University of Chicago, Department of Pathology, Chicago, IL, USA; present address: VIR Biotechnology, San Francisco, CA, USA; 920 927 University of Messina, Department of Human Pathology in Adult and Developmental Age “Gaetano Barresi”, Section of Pathology, Messina, Italy; 921 928 Kyushu University, Medical Institute of Bioregulation (MIB), Fukuoka, Japan; 922 929 Osaka International Cancer Institute, Department of Molecular and Cellular Biology, Osaka, Japan; 923 930 Juntendo University Graduate School of Medicine, Department of Research for Parkinson\'s Disease, Tokyo, Japan; 924 931 University of Modena and Reggio Emilia, Department of Life Sciences, Modena, Italy; 925 932 Juntendo University, Juntendo University Graduate School of Medicine, Division for Development of Autophagy Modulating Drugs, Tokyo, Japan; 926 933 University of North Texas Health Science Center, North Texas Eye Research Institute and Department of Pharmaceutical Sciences, Fort Worth, TX, USA; 927 934 University of Michigan, Life Sciences Institute, Department of Molecular and Integrative Physiology, Ann Arbor, MI, USA; 928 935 Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France; 929 937 University of Massachusetts Medical School, Department of Microbiology and Physiological Systems, Worcester, MA, USA; 930 938 National University of Córdoba, Clinical Biochemistry Department, CIBICI-CONICET, Córdoba, Argentina; 931 939 Stanford University School of Medicine, Department of Pathology, Stanford, CA, USA; 932 940 Akita University Graduate School of Medicine, Department of Ophthalmology, Akita, Japan; 933 941 Vascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, USA; South China University of Technology, Guangzhou First People\'s Hospital, School of Medicine and Institutes for Life Sciences, Guangzhou, Guangdong, China; 934 942 University of Copenhagen, Copenhagen Biocentre, Faculty of Health and Medical Sciences, Biotech Research & Innovation Centre (BRIC), Neuroinflammation Unit, Copenhagen N, Denmark; 935 943 Chiba University, Department of Biology, Chiba, Japan; 936 944 Keio University School of Medicine, Department of Neurology, Tokyo, Japan; 937 945 University College London, Department of Neuroscience, Physiology and Pharmacology, London, UK; 938 946 Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain; Universitat de Barcelona, Departament de Bioquímica I Biomedicina Molecular, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain;947 Barcelona Institute of Science and Technology (BIST), Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain; Universitat de Barcelona, Facultat de Biologia, Departament de Bioquimica i Biomedicina Molecular, Barcelona, Spain; 939 948 Hampton University, School of Pharmacy, Department of Pharmaceutical Sciences, Hampton, VA, USA; 940 949 Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Madrid, Spain; Department of Cell Biology and Immunology, Campus de Cantoblanco, Madrid, Spain; 941 950 RIKEN, Center for Sustainable Resource Science, Wako, Saitama, Japan; 942 951 Danish Cancer Society Research Center, Center for Autophagy, Recycling and Disease, Cell Death and Metabolism Unit, Copenhagen, Denmark; University of Copenhagen, Department of Cellular and Molecular Medicine, Copenhagen, Denmark; 943 952 University of Technology, Department of applied science, Division of Biotechnology, Baghdad, Iraq; 944 953 University of Maryland School of Medicine, Department of Microbiology and Immunology, Baltimore, MD, USA; 945 954 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Unidad de Bioquimica, Mexico City, Mexico; 946 955 University of Warwick, School of Life Sciences, Coventry, UK; 947 75 Université Paris-Saclay, INSERM ,UMR-S 1193, Châtenay-Malabry, France; 948 956 Lewis Katz School of Medicine at Temple University, Center for Translational Medicine, Philadelphia, PA, USA; 949 957 Houston Methodist Research Institute, Weill-Cornell Medicine, Houston, TX, USA; 950 958 Delft University of Technology, Kavli Institute of Nanoscience, Department of Bionanoscience, Delft, The Netherlands; 951 959 Lund University, Department of Experimental Medical Science, Laboratory of Molecular Neurogenetics, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund, Sweden; 952 960 Luxembourg Institute of Health, Tumor Immunotherapy and Microenvironment (TIME) group, Department of Oncology, Luxembourg City, Luxembourg; 953 961 Cancer Drug Resistance and Stem Cell Program, University of Sydney, NSW, Australia; 954 962 University Hospital of Regensburg, Institute of Clinical Microbiology and Hygiene, Regensburg , Germany; 955 963 Polish Academy of Sciences, Mossakowski Medical Research Centre, Laboratory of Ischemic and Neurodegenerative Brain Research, Warsaw, Poland; 956 964 Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 957 965 Université de Sherbrooke, Département d\'immunologie et de biologie cellulaire, Sherbrooke, Québec, Canada; 958 966 UMR7242, CNRS, Université de Strasbourg, Strasbourg, France; 959 967 Institute of Experimental Medicine CAS, Department of Neuroregeneration, Prague, Czech Republic; 960 968 Albert Einstein College of Medicine, Department of Developmental and Molecular Biology and Department of Genetics, New York, NY, USA; 961 969 University of Copenhagen, Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, Copenhagen, Denmark; 962 970 Aarhus University Hospital, Steno Diabetes Center Aarhus, Aarhus, Denmark; 963 971 University of Texas Southwestern Medical Center, Department of Molecular Biology, Dallas, TX, USA; 964 972 The First Affiliated Hospital of Nanjing Medical University, Department of Neurosurgery, Nanjing, Jiangsu, China; 965 973 Shanghai University of Traditional Chinese Medicine, Longhua Hospital, Cancer Institute, Shanghai, China; 966 974 Purdue University, Department of Nutrition Science, West Lafayette, IN, USA; 967 975 Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Solna, Stockholm, Sweden;976 The First Hospital of Jilin University, Department of Ear, Nose and Throat, Changchun, Jilin, China; 968 977 Nanjing Medical University, Nanjing First Hospital, Department of Neurology, Nanjing, China; 969 978 University of Pittsburgh, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA; 970 979 King\'s College London, Institute of Psychiatry, Psychology & Neuroscience, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK; 971 980 Wonkwang Univesity, Department of Biological Sciences, Iksan, Chunbuk, Korea; 972 981 The First Hospital of Jilin University, Cancer Center, Department of Hematology, Changchun, Jilin, China; 973 982 ZhejiangUniversity, Sir Run Run Shaw Hospital, School of Medicine, Key Lab of Biotherapy in Zhejiang Province, Hangzhou, China; 974 983 Xi\'an Jiaotong University, School of Medicine, the First Affiliated Hospital, Department of Nephrology, Xi\'an City, Shaanxi Province, China; 975 985 Huazhong University of Science and Technology, Liyuan hospital of Tongji Medical College, Department of Endocrinology, Wuhan, Hubei, China; 976 986 Chungnam National University School of Medicine, Infection Control Convergence Research Center, Daejeon, Korea; 977 987 Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse, Toulouse, France; 978 988 University of Rochester, Department of Anesthesiology and Perioperative Medicine, Rochester, NY, USA; 979 989 University of Sheffield, Department of Infection, Immunity and Cardiovascular Disease and the Bateson Centre, Sheffield, UK; 980 990 University of Helsinki, Institute of Biotechnology, Cell and Tissue Dynamics Programme and Electron Microscopy Unit, Helsinki, Finland; 981 991 Indian Institute of Science, Centre for BioSystems Science and Engineering, Bangalore, India; 982 992 Radboud University Medical Centre, Department of Internal Medicine, Nijmegen, The Netherlands; 983 993 Universidad Castilla La Mancha, Departmento Ciencias Medicas, Albacete, Spain; 984 994 Fudan University School of Pharmacy, Department of Biological Medicines, Shanghai, China; 985 995 The University of Suwon, Department of Health Science, Hwaseong, Gyeonggi, Korea; 986 996 Stony Brook University, Department of Pathology, Stony Brook, NY, USA; 987 997 Instituto Nacional de Enfermedades Respiratorias Isamel Cosío Villegas, Departamento de Investigación en Microbiología, Ciudad de México, México; 988 999 Gwangju Institute of Science and Technology, School of Life Sciences, Gwangju, South Korea; 989 1000 Korea Food Research Institute, Research Group of Natural Material and Metabolism, Jeollabuk-do, Korea; 990 1001 Ewha Womans University, Department of Biochemistry, College of Medicine, Seoul, Korea; 991 1002 Seoul National University, School of Biological Science, Seoul, Korea; 992 1003 Evelina Children\'s Hospital, Guy\'s & St Thomas\' NHS Foundation Trust, Children\'s Neuroscience Centre, London, UK; King\'s College London, Muscle Signalling Section, Randall Division of Cell and Molecular Biophysics, London, UK; King\'s College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), Department of Basic and Clinical Neuroscience, London, UK; 993 1004 Memorial Sloan Kettering Cancer Center, New York, NY, USA; 994 1005 University of Ulm, Department of Internal Medicine II, Molecular Cardiology, Ulm, Germany; 995 1006 University of Eastern Finland and Kuopio University Hospital, Department of Ophthalmology, Kuopio, Finland; 996 1007 University Tartu, Department of Pharmacology, Tartu, Estonia; 997 1008 University Medical Center Gottingen, Department of Experimental Neurodegeneration, Gottingen, Germany; 998 1009 University of Michigan, Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA; 999 1011 University of California, San Francisco UCSF Diabetes Center, Department of Cell and Tissue Biology, San Francisco, CA, USA; 1000 1012 University of Kansas Medical Center, Department of Microbiology, Molecular Genetics and Immunology, Kansas City, KS, USA; 1001 1013 Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, India; 1002 1014 National Research Council of Italy (CNR), Neuroscience Institute, Padua, Italy; 1003 1015 European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, UK; 1004 1016 Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland; 1005 1017 Karolinska Institutet, Department of Oncology-Pathology, Stockholm, Sweden; 1006 1018 Gifu University Graduate School of Medicine, Department of Cardioligy, Gifu, Japan; 1007 1019 Shimane University Faculty of Medicine, Internal Medicine 1, Izumo, Shimane, Japan; 1008 1020 Seoul National University, School of Biological Sciences, Seoul, Korea; 1009 1021 UT Southwestern Medical Center, Department of Surgery, Dallas, Texas, USA; 1010 1022 Chungbuk National University, Department of Biology Education, Seowon-Gu, Cheongju, Chungbuk, Korea; 1011 1023 CAESAR Research Center, Bonn, Germany;1024 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; 1012 1025 Niigata University Graduate School of Medical and Dental Sciences, Department of Cellular Physiology, Niigata, Japan; 1013 1026 St. Jude Children’s Research Hospital, Department of Immunology, Memphis, TN, USA; 1014 1027 Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA; 1015 1028 Florida Atlantic University, Charles E. Schmidt College of Medicine, Department of Biomedical Science, Boca Raton, FL, USA; 1016 1029 Semmelweis University, Budapest, Hungary; 1017 1030 National and Kapodistrian University of Athens, Medical School, Division of Molecular Oncology, Department of Biological Chemistry, Athens, Greece; 1018 1031 University of Minnesota, Institute for Translational Neuroscience, Department of Neuroscience, Minneapolis, MN, USA; 1019 1032 Jadavpur University, Department of Life Science and Biotechnology, Kolkata, India; 1020 1033 University of Otago, Department of Physiology-HeartOtago, Dunedin, Otago, New Zealand; 1021 1034 Hokkaido University, Department of Rheumatology, Endocrinology and Nephrology, Sapporo, Japan; 1022 1035 Max Planck Institute for Infection Biology, Berlin, Germany; 1023 1036 University of Eastern Finland, Faculty of Health Sciences, School of Pharmacy, Kuopio, Finland; 1024 1037 University of Arkansas for Medical Sciences, Little Rock, AR, USA; 1025 1038 Doshisha Women\'s College of Liberal Arts, Faculty of Pharmaceutical Sciences, Kyotanabe, Kyoto, Japan; 1026 1039 Commonwealth Scientific and Industrial Research Organization (CSIRO), Agriculture and Food, Brisbane, Queensland, Australia; 1027 1040 Chang Gung University, Department of Biochemistry and Molecular Biology, Taoyuan, Taiwan, Republic of China; 1028 1041 Flinders University, Flinders Health and Medical Research Institute, Adelaide, Australia; 1029 1042 Philipps University and University Hospital of Marburg, Department of Neuropathology, Marburg, Germany; 1030 1043 National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, MD, USA; 1031 1044 Oregon Health & Science University, Casey Eye Institute, Portland, OR, USA; 1032 1045 University of Münster, University Hospital, Department of Neurology with Institute of Translational Neurology, Münster, Germany; 1033 1046 University of Illinois at Urbana-Champaign, Department of Molecular and Integrative Physiology, Urbana, IL, USA; 1034 1047 Weill Cornell Medicine, Departments of Pediatrics and Cell and Developmental Biology, New York, NY, USA; 1035 1048 Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, Paris, France; 1036 1049 Queen Mary University of London, Barts Cancer Institute, London, UK; 1037 1050 University College London, MRC Laboratory for Molecular Cell Biology, London, UK; 1038 1051 Maastricht University Medical Center, GROW School for Oncology, Department of Radiotherapy, Maastricht|, The Netherlands; 1039 1052 Ben-Gurion University of the Negev, Faculty of Health Sciences, Department of Clinical Biochemistry and Pharmacology, Beer Sheva, Israel; 1040 1053 University of Sadat City, Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, Sadat City, Egypt; 1041 1054 Indiana University-Purdue University (IUPUI), Department of Pathology and Laboratory Medicine, Indianapolis, IN, USA; 1042 1055 University of Eastern Finland, School of Pharmacy, Kuopio, Finland; 1043 1056 Barkatullah University, Department of Biochemistry & Genetics, Bhopal, India; 1044 1057 Charité - Universitätsmedizin Berlin, Department of Anesthesiology and Intensive Care Medicine, Campus Charité Mitte and Campus Virchow-Klinikum, Berlin, Germany; 1045 1058 Columbia University, Vagelos College of Physicians and Surgeons, Department of Pathology and Cell Biology, New York, NY, USA; 1046 1059 Friedrich-Schiller-University Jena, University Hospital Jena, Institute of Human Genetics, Jena, Germany.; 1047 1060 Gyeongsang National University School of Medicine, Department of Biochemistry and Convergence Medical Sciences and Institude of Health Sciences, Jinju, Republic of Korea; 1048 1061 University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics, Minneapolis, MN, USA; 1049 1062 Kyungpook National University, School of Medicine, Department of Biochemistry and Cell Biology, Cell and Matrix Research Institute, Daegu, Korea; 1050 1063 Daegu Gyeongbuk Institute of Science and Technology (DGIST), Department of Brain and Cognitive Sciences, Daegu, Korea; 1051 1064 Dankook University, College of Medicine, Department of Pharmacology, Cheonan, Chungnam, Korea; 1052 1065 Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cell Factory Research Center, Daejeon, Korea; University of Science and Technology, KRIBB School of Biotechnology, Department of Environmental Biotechnology, Daejeon, Korea; 1053 1066 Dankook University, College of Dentistry, Cheonan, Korea; 1054 1067 Seoul National University College of Medicine, Department of Biomedical Sciences, and Ophthalmology, Seoul, Korea; 1055 1068 Konkuk University, Department of Stem Cell and Regenerative Biotechnology, Seoul, Korea; 1056 1069 Kyung Hee University, Department of Oral Biochemistry and Molecular Biology, School of Dentistry, Seoul, Korea; 1057 1070 Sookmyung Women\'s University, Department of Biological Sciences, Seoul, Korea; 1058 1071 Korea Research Institute of Chemical Technology, Center for Convergent Research of Emerging Virus Infection, Daejeon, Korea; 1059 1072 Penn State College of Medicine, Department of Cellular and Molecular Physiology, Hershey, PA, USA; 1060 1073 Weizmann Institute of Science, Department of Molecular Genetics, Rehovot, Israel; 1061 1074 New York University School of Medicine, Department of Radiation Oncology, Perlmutter Cancer Center, New York, NY, USA; 1062 1075 National Institute of Biomedical Innovation, Health and Nutrition (NIBIOHN), Center for Rare Disease Research, Ibaraki, Osaka, Japan; 1063 1076 AstraZeneca, Bioscience, Oncology R&D, Cambridge, UK; 1064 1077 University College London, Institute of Healthy Ageing, Department of Genetics, Evolution & Environment, London, UK; 1065 1078 University of Utah, Huntsman Cancer Institute, Salt Lake City, UT, USA; University of Utah School of Medicine, Division of Oncology, Department of Internal Medicine, Salt Lake City, UT, USA; 1066 1079 Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research London, Sutton, UK; 1067 1080 St. Boniface Hospital Albrechtsen Research Centre, Departments of Physiology and Pathophysiology, and Pharmacology and Therapeutics, Max Rady College of Medicine; Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; 1068 1081 Vavilov Institute of General Genetics RAS, Department of Epigenetics, Moscow, Russia; 1069 1082 S&J Kishi Research Corporation, Jupiter, FL, USA; 1070 1083 Nihon Pharmaceutical University, Department of Pharmaceutical and Medical Business Sciences, Bunkyoku, Tokyo, Japan; 1071 1084 St. Marianna University Graduate School of Medicine, Department of Molecular Neuroscience, Kanagawa, Japan; 1072 1085 Nagasaki University, Institute of Biomedical Sciences, Department of Clinical Research Pharmacy, Nagasaki, Japan; 1073 1086 Albert Einstein College of Medicine, Departments of Medicine and Cell Biology and Wilf Family Cardiovascular Research Institute, Bronx, NY, USA; 1074 1087 University of Copenhagen, Department of Neuroscience, Copenhagen, Denmark; 1075 1088 Perelman School of Medicine at the University of Pennsylvania, Department of Medicine (Hematology-Oncology), Philadelphia, PA, USA; 1076 1089 Friedrich-Baur-Institute, Department of Neurology, University of Munich, Munich, Germany; 1077 1090 University Hospital Erlangen, Department of Molecular Neurology, Erlangen, Germany; 1078 1091 University of Oslo, Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, Montebello, Norway; Oslo University Hospital, Department of Molecular Cell Biology, Institute for Cancer Research, Montebello, Norway; 1079 136 Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany;1443 The University of Tokyo, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Tokyo, Japan; 1080 1093 The Hong Kong Polytechnic University, Department of Applied Biology and Chemical Technology, Hong Kong, China; 1081 1094 Icahn School of Medicine at Mount Sinai, Department of Geriatrics and Palliative Medicine, New York, NY, USA; 1082 1095 The University of Tokyo, Institute for Quantitative Biosciences, Laboratory of RNA Function, Tokyo, Japan; Albert Einstein College of Medicine, Department of Anatomy and Structural Biology, Bronx, NY, USA; 1083 1096 New York Institute of Technology, College of Osteopathic Medicine, Department of Biomedical Sciences, Old Westbury, NY, USA; 1084 1097 Johann Wolfgang Goethe-University Frankfurt am Main, Faculty of Computer Science and Mathematics, Institute of Computer Science, Frankfurt am Main, Germany; 1085 1098 University Medicine Göttingen, Clinic for Neurology, Göttingen, Germany; 1086 1099 University Hospital Münster (UKM), Institute of Musculoskeletal Medicine, Münster, Germany; 1087 1100 Goethe University Hospital Frankfurt, Neuroscience Center, Experimental Neurosurgery, Frankfurt/Main, Germany; 1088 1101 Division of Brain Disease Research, Korea National Institute of Health, Cheongju-si, Republic of Korea; 1089 1102 Juntendo University Graduate School of Medicine, Department of Cell Biology and Neuroscience, Hongo, Bunkyo-ku, Tokyo, Japan; 1090 1103 University of Graz, Institute of Molecular Biosciences, BioTechMed-Graz, Graz, Austria; 1091 1104 Juntendo University School of Medicine, Department of Physiology, Bunkyo-ku, Tokyo, Japan; 1092 1105 Sapporo Higashi Tokushukai Hospital, Advanced Surgery Center, Sapporo, Hokkaido, Japan; 1093 1106 The Abigail Wexner Research Institute at Nationwide Children\'s Hospital, Center for Microbial Pathogenesis, Columbus, OH, USA; 1094 1107 Earlham Institute, Norwich, UK; 1095 1109 Newcastle University, Ageing Research Laboratories, Institute for Cell and Molecular Biosciences, Newcastle upon Tyne, UK; 1096 1110 Norwegian University of Science and Technology (NTNU), Department of Biotechnology and Food Science, Trondheim, Norway; Korsnes Biocomputing (KoBio), Trondheim, Norway; 1097 1111 University of Eastern Finland, Department of Ophthalmology, Kuopio, Finland; 1098 1112 Indiana University School of Medicine, Indianapolis, IN, USA; 1099 1113 Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima, Japan; 1100 1114 China National Rice Research Institute, State Key Laboratory of Rice Biology, Hangzhou. China; 1101 1115 Democritus University of Thrace, Department of Radiotherapy/Oncology, Alexandroupolis, Greece; 1102 1116 Kanazawa Medical University, Department of Diabetology & Endocrinology, Uchinadacho, Ishikawa, Japan; 1103 1117 Fukuoka University, Faculty of Pharmaceutical Sciences, Department of Biochemistry, Fukuoka, Japan; 1104 1118 University of Freiburg, Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, Freiburg, Germany; University of Freiburg, CIBSS - Centre for Integrative Biological Signalling Studies, Freiburg, Germany; 1105 1119 Northwestern University Feinberg School of Medicine, Department of Neurology, Chicago, IL, USA; 1106 1120 University of Texas, Southwestern Medical Center, Dallas, TX, USA; 1107 1121 Queen\'s University of Belfast, Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK; 1108 1122 Université Lyon, Université Claude Bernard Lyon 1, CNRS UMR 5310, INSERM U1217, Institut NeuroMyoGène, Lyon, France; 1109 1123 Université de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Paris, France; Institut Gustave Roussy, Metabolomics and Cell Biology Platforms, Villejuif, France; Hôpital Européen Georges Pompidou, AP-HP, Pôle de Biologie, Paris, France; Chinese Academy of Medical Sciences, Suzhou Institute for Systems Medicine, Suzhou, China; Karolinska Institute, Karolinska University Hospital, Department of Women\'s and Children\'s Health, Stockholm, Sweden; 1110 1124 Babraham Institute, Babraham, Cambridge, UK; 1111 1125 Tokyo University of Science, Department of Applied Biological Science, Noda, Chiba, Japan; 1112 1126 VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Leuven, Belgium; 1113 1127 University of Bonn, LIMES Institute, Bonn, Germany; 1114 1128 Emory University, Department of Pharmacology and Chemical Biology, School of Medicine, Atlanta, GA, USA; 1115 1129 PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India; 1116 1130 University of Houston, Department of Pharmacological and Pharmaceutical Sciences, Houston, TX, USA; 1117 1131 Julius L. Chambers Biomedical/Biotechnology Research Institute (BBRI) and North Carolina Central University, Department of Pharmaceutical Sciences, Durham, NC, USA; 1118 1132 International Centre for Genetic Engineering and Biotechnology, Cellular Immunology Group, Aruna Asaf Ali Marg, New Delhi, India; 1119 1133 Shiga University of Medical Science, Department of Medicine, Otsu, Shiga, Japan; 1120 1134 Kalinga institute of industrial technology (KIIT-DU), School of Biotechnology, Campus 11, Patia, Bhubaneswar, Odisha, India; 1121 1135 St. Jude Children’s Research Hospital, Department of Pathology, Memphis, TN, USA; 1122 1136 Indian Institute of Technology (IIT) Guwahati, Department of Biosciences and Bioengineering, Guwahati, Assam, India; 1123 1137 Virginia Commonwealth University, Department of Computer Science, Richmond, VA, USA; 1124 1138 University of Colorado Anschutz Medical Campus, Department of Pharmacology, Aurora, CO, USA; 1125 1139 Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul, Turkey; 1126 1140 Wonkwang University School of Medicine, Zoonosis Research Center, Iksan, Jeonbuk, Korea; 1127 1141 Keimyung University, School of Medicine, Department of Immunology, Daegu, Korea; 1128 1142 Protein Metabolism Medical Research Center and Department of Biomedical Sciences, Seoul National University School of Medicine, Seoul, Korea; 1129 1143 University of California, Irvine School of Medicine, Irvine, CA, USA; 1130 1144 INRS, INRS-Institut Armand-Frappier. Montréal, QC, Canada; 1131 1145 University of Burgundy, Centre Georges François Leclerc, Department of Medical Oncology, Dijon, France; 1132 1478 University of Ferrara, Department of Translational Medicine, Ferrara, Italy; 1133 1146 Cellular Microbiology and Physics of Infection Group, Center for Infection and Immunity of Lille, Institut Pasteur de Lille, CNRS, INSERM, CHU Lille, University of Lille, Lille Cedex, France; 1134 1147 University of Ottawa, Department of Cellular & Molecular Medicine, Ottawa, Ontario, Canada; 1135 1148 Huazhong Agricultural University, National Key Laboratory of Crop Genetic Improvement, Wuhan, China; 1136 1149 Macquarie University, Faculty of Medicine, Health and Human Sciences, Department of Biomedical Science, Centre for Motor Neuron Disease Research, Sydney, NSW, Australia; 1137 1150 University of California, San Francisco Department of Ophthalmology, San Francisco, CA, USA; 1138 1151 National Yang-Ming University, Department of Life Sciences and Institute of Genome Sciences, Taipei, Taiwan; 1139 1152 Yale University, Department of Cellular and Molecular Physiology, New Haven, CT, USA; 1140 1153 School of Biochemistry, University of Bristol, Bristol, UK; 1141 1154 Penn State College Medicine, Department of Cellular and Molecular Physiology, Hershey, PA, USA; 1142 1155 University of Greifswald, Institute of Pharmacy, Greifswald, Germany; 1143 1156 Stockholm University, Department of Biochemistry and Biophysics, Stockholm, Sweden; 1144 1157 Johannes Kepler University Linz, Kepler University Hospital GmbH, Institute of Pathology and Molecular Pathology, Linz, Austria; 1145 1158 University Bourgogne Franche-Comté, AgroSup Dijon, PAM UMR A 02.102, Dijon, France; 1146 1159 IGBMC, Inserm U1258, Cnrs UMR7104, Strasbourg University, Illkirch, France; 1147 1160 Mayo Clinic, Department of Medicine, Division of Gastroenterology and Hepatology, Rochester, MN, USA; 1148 1161 University of Virginia, Department of Cell Biology, Charlottesville, VA, USA; 1149 430 University of Chile, Faculty of Chemical and Pharmaceutical Sciences, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile;878 UT Southwestern Medical Center, Departments of Medicine (Cardiology) and Molecular Biology, Dallas, TX, USA; 1150 1162 Macau University of Science and Technology, State Key Laboratory of Quality Research in Chinese Medicine, Taipa, Macau, China; 1151 1163 The Hong Kong Polytechnic University, Faculty of Health and Social Sciences, Department of Health Technology and Informatics, Hunghom, Hong Kong; 1152 1164 University of Nottingham, School of Life Sciences, Nottingham, UK; 1153 1165 Sichuan Academy of Medical Science & Provincial Hospital, Medical School of UESTC, Chengdu, China; 1154 1166 Université Paris Saclay, Institut des Neurosciences Paris-Saclay (Neuro-PSI)-CNRS UMR 9197, Orsay France; 1155 1167 McGill University Health Center, Department of Medicine, Cancer Research Program, Montreal, QC, Canada; 1156 1168 Research Institute of the McGill University Health Centre, Meakins-Christie Laboratories and Translational Research in Respiratory Diseases Program, Montréal, Québec, Canada; McGill University, Department of Critical Care and Division of Experimental Medicine, Montréal, Québec, Canada; UQAM, Faculté des Sciences, Département des Sciences de l\'activité physique, Montréal, Canada; 1157 1169 Ulsan National Institute of Science and Technology, Department of Biological Sciences, Ulsan, Korea; 1158 1170 National Taipei University of Nursing and Health Sciences, School of Nursing, Taipei, Taiwan; 1159 1171 KAIST, Department of Biological Sciences, Daejon, Korea; 1160 1172 Konkuk University, School of Medicine, Department of Anatomy, Seoul, Korea; 1161 1173 Korea Advanced Institute of Science and Technology, Graduate School of Medical Science and Engineering, Daejeon, Korea; 1162 1174 QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia; 1163 1175 Hannam University, Department of Biological Sciences and Biotechnology, Daejeon, South Korea; 1164 1176 Chungnam National University, Graduate School of Analytical Science and Technology (GRAST), Daejeon 305-764, Republic of Korea; 1165 1177 University of Michigan, Department of Molecular & Integrative Physiology, Ann Arbor, MI, USA; 1166 1178 Incheon National University, College of Life Sciences and Bioengineering, Division of Life Sciences, Incheon, Korea; 1167 1179 Yonsei University College of Medicine, Department of Pharmacology, Seoul, Korea; 1168 1180 Seoul National University College of Medicine, Department of Biochemistry and Molecular Biology, Seoul, Korea; 1169 1181 Yonsei University College of Medicine, Severance Biomedical Science Institute and Department of Internal Medicine, Seoul, Korea; 1170 1182 Ajou University Graduate School of Medicine, Department of Biomedical Sciences, Suwon, Gyeonggi, Korea; 1171 1183 Seoul National University College of Medicine, Department of Biomedical Sciences, Neuroscience Research Institute, Seoul, Korea; 1172 1184 University of Kansas Medical Center, Department of Biochemistry and Molecular Biology, Kansas City, KS, USA; 1173 1185 DGIST, Department of Brain & Cognitive Sciences, Daegu, Korea; 1174 1186 University of Arizona College of Medicine, Department of Basic Medical Sciences, Phoenix, AZ, USA; 1175 1187 Ditmanson Medical Foundation Chia-Yi Christian Hospital, Translational Medicine Research Center, Chiayi City, Taiwan; 1176 1188 Yonsei University College of Medicine, Department of Internal Medicine, Seoul, Korea; 1177 1189 University of West Florida, Department of Movement Sciences and Health, Pensacola, FL, USA; 1178 1190 University of Michigan, Rogel Cancer Center, Department of Periodontics and Oral Medicine, Department of Otolaryngology - Head and Neck Surgery, Ann Arbor, MI, USA; 1179 1191 National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA; 1180 1192 University of Maribor, Faculty of Medicine, Maribor, Slovenia; University of Maribor, Faculty of Natural Sciences and Mathematics, Department of Biology, Maribor, Slovenia; University of Maribor, Faculty of Chemistry and Chemical Engineering, Maribor, Slovenia; Medical University of Graz, Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Graz, Austria;1193 Medical University of Graz, Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Graz, Austria; 1181 1194 Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China; 1182 1195 Institut National de la Santé et de la Recherche Médicale (Inserm), Université de Paris, Paris Cardiovascular Center - PARCC, Paris, France; 1183 1196 Universidade Federal do Rio Grande do Sul (UFRGS), Center of Biotechnology and Department of Biophysics, Porto Alegre, RS, Brazil; 1184 1197 USC Norris Comprehensive Cancer Center , Los Angeles, CA, USA; 1185 1198 University of Pisa, Department of Translational Research and New Technologies in Medicine and Surgery, Pisa, Italy; 1186 1330 Universidad Autónoma de Madrid, Department of Biology, Madrid, Spain; 1187 1199 University of São Paulo, School of Pharmaceutical Sciences of Ribeirão Preto, Department of Clinical Analyses, Toxicology and Food Sciences, Ribeirão Preto, SP, Brazil; 1188 1200 University of Luxembourg, Department of Life Sciences and Medicine, Molecular Disease Mechanisms Group, Belval, Luxembourg; 1189 1201 The Chinese University of Hong Kong, Faculty of Medicine, School of Biomedical Sciences, Shatin, New Territories, Hong Kong; 1190 1202 Icahn School of Medicine at Mount Sinai, Department of Medicine, New York, NY, USA; 1191 1203 Royal Veterinary College, London, UK; UCL Queen Square Institute of Neurology, Department of Neurodegenerative Disease, London, UK; 1192 1204 La Jolla Institute for Immunology and University of California San Diego, Laboratory of Inflammation Biology, La Jolla, CA, USA; 1193 1205 College of Life Science and Technology, Jinan University, Guangzhou, China; 1194 1206 Fudan University, Shanghai Cancer Center and Institutes of Biomedical Sciences, Shanghai, China; 1195 1207 Sun Yat-sen University, Sun Yat-sen Memorial Hospital, Department of Pathology, Guangzhou, Guangdong Province, China; 1196 1208 Sichuan University, West China Hospital, State key laboratory of biotherapy, Chengdu, Sichuan, China; 1197 1209 Virginia Polytechnic Institute, Department of Biological Sciences, Blacksburg, VA, USA; 1198 1210 Children\'s Hospital of Soochow University, Institute of Pediatric Research, Suzhou, China; 1199 1211 Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA; 1200 1212 Jinan University, College of Life Science and Technology, Department of Biology, Guangzhou, China; 1201 1213 Virginia Commonwealth University, Departement of Pharmacology and Toxicology, Richmond, VA, USA; 1202 1214 Fudan University, Hospital of Obstetrics and Gynecology, Institute of Obstetrics and Gynecology, Laboratory for Reproductive Immunology, Shanghai, China; 1203 1215 South China Normal University, School of Life Sciences, Institute of Insect Science and Technology, Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou, China; 1204 1216 Emory University School of Medicine, Department of Pharmacology and Chemical Biology, Atlanta, GA, USA; 1205 1217 Boston Children’s Hospital, Harvard Medical School, Departments of Urology and Surgery, Boston, MA, USA; 1206 1218 Stanford University, Department of Gastroenterology & Hepatology, Stanford, CA, USA; 1207 1219 Chinese Academy of Agricultural Sciences, Institute of Plant Protection, State Key Laboratory for Biology of Plant Diseases and Insect Pests, Beijing, China; 1208 1220 Chinese Academy of Agriculture Sciences, Lanzhou Veterinary Research Institute, State Key Laboratory of Veterinary Etiological Biology, Lanzhou, Gansu, China; 1209 1221 Chinese Academy of Sciences, Hefei Institutes of Physical Science, High Magnetic Field Laboratory, Hefei, Anhui Province, China; 1210 1222 Army Medical University, Department of Bichemistry and Molecular Biology, Chongqing, Chongqing, China; 1211 1223 The Wistar Institute, Molecular and Cellular Oncogenesis Program, Philadelphia, PA, USA; 1212 1225 Sun Yat-sen University, The 3rd Affiliated Hospital of Sun Yat-sen University, Vaccine Research Institute, Guangzhou, China; 1213 1226 Nanjing Agricultural University, College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing , China; 1214 1227 Free University of Berlin, Department of Biology, Chemistry and Pharmacy, Berlin, Germany; 1215 1228 Northwest A&F University, College of Life Sciences, Yangling, Shaanxi, China; 1216 1229 Academia Sinica, Institute of Cellular and Organismic Biology, Taipei, Taiwan; 1217 1230 Nathan S. Kline Institute, Center for Dementia Research, Orangeburg, NY, USA; 1218 1231 National Institute of Child Health and Human Development, National Institutes of Health, Cell Biology and Neurobiology Branch, Bethesda, MD, USA; 1219 1232 Konkuk University, Department of Veterinary Medicine, Seoul, Korea; 1220 1233 São Paulo State University, Botucatu Medical School, Center for Evaluation of Environmental Impact on Human Health (TOXICAM), Department of Pathology, Botucatu, SP, Brazil; 1221 1234 San Raffaele Open University and IRCCS San Raffaele Pisana, Laboratorio di Patologia Cellulare e Molecolare, Rome, Italy; 1222 1235 First Affiliated Hospital of Nanjing Medical University, Department of Neurosurgery, Nanjing, China; Jiangsu Province Hospital, Department of Neurosurgery, Nanjing, China; 1223 1236 Division of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, Kaohsiung, Taiwan; I-Shou University, College of Medicine, School of Medicine, Kaohsiung, Taiwan; 1224 1237 Mackay Memorial Hospital, Department of Pediatrics, Taipei, Taiwan; Mackay Medical College, Department of Medicine, New Taipei,Taiwan; 1225 1238 Zhejiang Academy of Agricultural Sciences, Institute of Plant Protection and Microbiology, State Key Laboratory for Managing Biotic and Chemical Treatments to the Quality and Safety of Agro-products, Hangzhou, China; Zhejiang University, Institute of Biotechnology, Hangzhou, China; 1226 1239 Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan, Ann Arbor, MI, USA; 1227 1240 National Health Research Institutes, Institute of Biomedical Engineering and Nanomedicine, Zhunan, Miaoli, Taiwan; 1228 1241 Chang Gung Memorial Hospital, Liver Research Center, Linkou, Taoyuan, Taiwan; Chang Gung University, College of Medicine, Graduate Institute of Biomedical Sciences, Taoyuan, Taiwan; Chang Gung University of Science and Technology, College of Human Ecology, Research Center for Chinese Herbal Medicine, Taoyuan, Taiwan; 1229 1242 The Ohio State University, Wexner Medical Center, Department of Surgery, Columbus, OH, USA; 1230 1243 School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China; 1231 1244 Huazhong University of Science and Technology, College of Life Science and Technology, Hubei Bioinformatics and Molecular Imaging Key Laboratory, Key Laboratory of Molecular Biophysics of Ministry of Education, Wuhan, Hubei, China; 1232 1245 Harvard Medical School, Massachusetts General Hospital, Gastrointestinal Unit/Medicine, Boston, MA, USA.; 1233 1246 Mayo Clinic, Department of Biochemistry and Molecular Biology, Rochester, MN, USA; 1234 1247 Brigham and Women\'s Hospital, Harvard Medical School, Center for Nanomedicine and Department of Anesthesiology, Boston, MA, USA; 1235 1248 Instituto de Biofisica da UFRJ, Rio de Janeiro, Brazil; 1236 1249 Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Neurology, Munich, Germany; 1237 1250 Indiana University School of Medicine, Department of Pediatrics and Center for Diabetes and Metabolic Diseases, Indianapolis, IN, USA; 1238 1251 University of Singapore, Department of Biological Sciences, Singapore; 1239 1252 University of Maryland School of Medicine, Department of Anesthesiology, Baltimore, MD, USA; 1240 1192 University of Maribor, Faculty of Medicine, Maribor, Slovenia; University of Maribor, Faculty of Natural Sciences and Mathematics, Department of Biology, Maribor, Slovenia; University of Maribor, Faculty of Chemistry and Chemical Engineering, Maribor, Slovenia; Medical University of Graz, Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Graz, Austria; 1241 1253 University of Iowa, Fraternal Order of Eagles Diabetes Research Center, Obesity Research and Education Initiative, Abboud Cardiovascular Research Center, Department of Health and Human Physiology, Iowa City, IA, USA; 1242 1254 Poznan University of Medical Sciences, Department of Clinical Chemistry and Molecular Diagnostics, Poznan, Poland; 1243 1255 Duke University, Department of Ophthalmology, Durham, NC, USA; 1244 1256 Department of Microbiology & Immunology, Dalhousie University, Halifax, Nova Scotia, Canada;964 Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 1245 1257 Institute of Neuroscience of Soochow University, Suzhou, China; 1246 1258 Chinese Academy of Sciences, Center for Biosafety Mega-Science, Institute of Microbiology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Chaoyang District, Beijing, China; 1247 1259 Nankai University, Department of Microbiology, Tianjin, China; 1248 1260 Guangdong Medical University, Institute of Nephrology, and Zhanjiang Key Laboratory of Prevention and Management of Chronic Kidney Disease, Zhanjiang, Guangdong, China; 1249 1261 Capital Medical University, Beijing Institute for Brain Disorders, Beijing, China; 1250 1262 Central South University, School of Life Sciences, Molecular Biology Research Center, Changsha, Hunan, China; 1251 1263 The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; 1252 1264 Columbia University, Naomi Berrie Diabetes Center, Department of Pathology and Cell Biology, College of Physicians and Surgeons, New York, NY, USA; 1253 1265 University of New Mexico Health Sciences Center, Department of Biochemistry and Molecular Biology, Albuquerque, NM, USA; 1254 1266 Henan Academy of Agricultural Sciences, Institute of Plant Nutrition, Agricultural Resources and Environmental Science, Jinshui District, Zhengzhou, Henan, China; 1255 1267 Zhejiang University School of Medicine, Department of Biochemistry and Department of Cardiology of the Second Affiliated Hospital, Hangzhou, Zhejiang, China; 1256 1268 Zhejiang University, Biotechnology Institute, State Key Laboratory for Rice Biology, Hangzhou, China; 1257 1269 CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; 1258 1270 Harvard Medical School, Department of Microbiology; Brigham and Women\'s Hospital, Division of Infectious Diseases, Boston, MA, USA; 1259 1271 University of Colorado at Boulder, Department of Biochemistry, Boulder, CO, USA; 1260 1272 ShanghaiTech University, School of Life Science and Technology, Shanghai, China; 1261 1273 Saarland University, Department of Neurology, Homburg, Germany; 1262 1274 Johns Hopkins University, Department of Biochemistry and Molecular Biology, Baltimore, MD, USA; 1263 1275 Shenyang Pharmaceutical University, Department of Pharmacology, Shenyang, China; 1264 1276 Tsinghua Unversity, School of Life Sciences, Beijing, China; 1265 1277 University of Texas MD Anderson Cancer Center, Department of Sarcoma Medical Oncology, Houston, TX, USA; 1266 1278 University of Bourgogne Franche-Comté, Team ’Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism (EA7270)/Inserm, Faculty of Sciences Gabriel, Dijon, France; 1267 1279 Universitat Autonoma de Barcelona, Departament of Biochemistry and Institut Neurosciences, Faculty of Medicine, Bellaterra, Barcelona, Spain; 1268 1280 Vall d´Hebron Research Institute, Barcelona, Spain; 1269 1281 Oslo University Hospital, Institute for Cancer Research, Department of Molecular Cell Biology, Oslo, Norway; 1270 1282 Harvard Medical School, Brigham and Women\'s Hospital, Department of Neurology, Boston, MA, USA; 1271 1283 London School of Hygiene & Tropical Medicine, Department of Infection Biology, London, UK; 1272 417 National University of Singapore, Yong Loo Lin School of Medicine, Department of Biochemistry, Singapore; 1273 1284 Universidad Autonoma de Madrid, School of Medicine, Department of Pharmacology, Madrid, Spain; 1274 1285 Universidad Autónoma de Madrid, Departamento de Biología Molecular, Madrid, Spain and Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain; 1275 1286 Universidad de Zaragoza, IA2, IIS, Laboratorio de Genética Bioquímica (LAGENBIO), Zaragoza, Spain; Universidad de Zaragoza, IA2, IIS, Centro de Encefalopatías y Enfermedades Transmisibles Emergentes, Zaragoza, Spain; 1276 1287 University Medical Center Utrecht, Center for Molecular Medicine, Utrecht, The Netherlands; Regenerative Medicine Center, Utrecht, The Netherlands; 1277 1288 University of Turin, Department of Veterinary Sciences, Grugliasco (TO), Italy; 1278 1289 Université de Paris, Centre de Recherche sur l\'Inflammation (CRI), Inserm-UMR1149, Paris, France; 1279 1290 Newcastle University, Institute of Translation and Clinical Studies, Precision Medicine, The Medical School, Newcastle upon Tyne, UK; 1280 1291 State University of New York at Buffalo, Buffalo, NY, USA; 1281 1292 Universidad Mayor, Center for Integrative Biology and Geroscience for Brain, Health and Metabolism, Santiago, Chile; 1282 1293 National University of Singapore, Yong Loo Lin School of Medicine, Department of Physiology, Singapore; 1283 1884 Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; 1284 1294 University of Macau, Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, Taipa, Macao, China; 1285 1295 Institute of Virology, University Hospital Essen, Essen, Germany; 1286 1296 Pfizer Inc, DSRD, La Jolla, CA, USA; 1287 1297 University of St Andrews, School of Medicine, North Haugh, St Andrews, UK; 1288 1298 Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal and ICVS/3B\'s - PT Government Associate Laboratory, Braga/Guimarães, Portugal; 1289 1299 Duke University, School of Medicine, Duke Center for Virology, Department of Molecular Genetics and Microbiology, Durham, NC, USA; 1290 1301 BC Cancer, Trev and Joyce Deeley Research Centre, Victoria, BC, Canada; University of Victoria, Department of Biochemistry and Microbiology, Victoria, BC, Canada; 1291 1302 University of Copenhagen, Biotech Research and Innovation Centre, Copenhagen, Denmark; 1292 1303 University of Würzburg, Institute of Clinical Neurobiology, Würzburg, Germany; 1293 1304 University of British Columbia, Centre for Heart Lung Innovation/Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada; 1294 1305 Kunming Institute of Zoology, Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming, Yunnan, China; 1295 1306 Plymouth University, Peninsula School of Medicine and Dentistry, Plymouth, UK; 1296 1307 Huazhong Agricultural University, Laboratory of Molecular Nutrition for Aquatic Economic Animals, Fishery College, Wuhan, China; 1297 1308 RWTH Aachen University, Medical School, Institute of Biochemistry and Molecular Biology, Aachen, Germany; 1298 1309 International Clinical Research Center, St\'Anne University Hospital, Brno, Czech Republic; Institute of Molecular Biology and Biophysics, (Federal Research Center of Fundamental and Translational Medicine), Novosibirsk, Siberia, Russia; 1299 1310 University of Oslo, Faculty of Medicine, Institute of Basic Medical Sciences, Department of Molecular Medicine, Oslo, Norway; University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, Centre for Cancer Cell Reprogramming, Oslo, Norway; 1300 1311 Justus Liebig University, University Hospital Giessen and Marburg GmbH, Departement of Ophthalmology, Giessen, Germany; 1301 1312 The Hong Kong Polytechnic University, Department of Health Technology and Informatics, Hong Kong, China; 1302 1313 Shandong Normal University, Shandong Provincial Key Laboratory of Plant Stress, College of Life Sciences, Jinan, Shandong, China; 1303 1314 Yale School of Medicine, Department of Cell Biology, New Haven, CT, USA; 1304 1315 Guangzhou Medical University, Department of Histology and Embryology, Guangzhou, China; 1305 1316 Soochow University, Institute of Neuroscience, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Suzhou, Jiangsu, China; 1306 1317 Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA; 1307 1318 Air Force Medical University, Xijing Hospital, Department of Clinical Laboratory, Xi\'an, China; 1308 1319 Tianjin Medical University, Department of Biochemistry and Molecular Biology; School of Basic Medical Sciences, Tianjin Key Laboratory of Medical Epigenetics, Tianjin, China; 1309 1320 Albert Einstein College of Medicine, Department of Pathology. Bronx, NY, USA; 1310 1321 Iowa State University, Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Ames, IA, USA; 1311 1322 Michigan State University, College of Human Medicine, Grand Rapids, MI, USA; 1312 1323 Ben May Department for Cancer Research, University of Chicago, Chicago IL, USA.; 1313 1324 Perelman School of Medicine at the University of Pennsylvania, Department of Neuroscience, Philadelphia, PA, USA; 1314 1325 University of Graz, Institute of Molecular Biosciences, BioTechMed-Graz, BioHealth, Graz, Austria; 1315 1326 University of Texas Health San Antonio, Department of Medicine, San Antonio, TX, USA; 1316 1327 Albert Einstein College of Medicine, Institute for Aging Studies, Department of Developmental and Molecular Biology, Bronx, NY, USA; 1317 1328 RIKEN, Laboratory for Retinal Regeneration, Kobe, Hyogo, Japan; 1318 1329 Tokyo Medical and Dental University, Department of Cardiovascular Medicine, Tokyo, Japan; 1319 1981 Justus-Liebig University, Department of Internal Medicine, Universities of Giessen & Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Giessen, Germany; 1320 1331 Part overlaps with Costanza Montagna: Danish Cancer Society Research Center, Computational Biology Laboratory, Copenhagen, Denmark; Danish Cancer Society Research Center, Computational Biology Laboratory, Copenhagen, Denmark; 1321 1332 Cellular and Molecular Signaling, New York, NY, USA; 1322 1333 Central Michigan University, Department of Psychology and Neuroscience Program, Mt. Pleasant, MI, USA; 1323 1334 Inserm U1138, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, Paris, France; 1324 1335 University of Naples Federico II, Department of Biology, Naples, Italy; 1325 1336 Washington University in St. Louis, Department of Cell Biology and Physiology, St. Louis, MO, USA; 1326 1337 CSIR - Indian Institute of Integrative Medicine, Department of Cancer Pharmacology, Sanat Nagar, Srinagar, Jammu and Kashmir, India; 1327 1338 National University of Singapore, Yong Loo Lin School of Medicine, Department of Physiology, Mitochondrial Physiology and Metabolism Lab, Singapore; National University of Singapore, NUHS Centre for Healthy Ageing, Singapore; 1328 2317 Center for Global Health, Catholic University of the Sacred Heart, Rome, Italy; 1329 1340 Oregon Health and Science University, Knight Cardiovascular Institute, Portland, OR, USA; 1330 1341 Iowa State University, Department of Biomedical Sciences, Ames, IA, USA; 1331 1342 The Chinese University of Hong Kong, The Prince of Wales Hospital, The Faculty of Medicine, Department of Orthopaedics and Traumatology, New Territories, Shatin, Hong Kong, China; 1332 1343 Dana-Farber Cancer Institute, Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Boston, MA, USA; 1333 1344 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; CAESAR Research Center, Bonn, Germany; 1334 1346 Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Division of Immunology, Transplantation and Infectious Diseases, Milano, Italy; 1335 1347 Virginia Commonwealth University School of Medicine, VCU Institute of Molecular Medicine, Massey Cancer Center, Department of Microbiology and Immunology, Richmond, VA, USA; 1336 2316 Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India; 1337 1348 KU Leuven, Department of Imaging and Pathology, Leuven, Belgium; 1338 1349 University College London, School of Pharmacy, Department of Pharmacology, London, United Kingdom; 1339 1350 Massachusetts General Hospital, Department of Molecular Biology, Boston, MA, USA; 1340 1351 Université Côte d\'Azur, INSERM, C3M, Nice, France; 1341 1352 Presidio San Paolo Polo Universitario, Dipartimento di Scienze della Salute San Paolo, Milano, Italy; 1342 1353 University of Milan, Department of Pharmacological and Biomolecular Sciences, Milan, Italy; 1343 1355 Consiglio Nazionale delle Ricerche, Istituto di Biochimica e Biologia Cellulare, Monterotondo scalo (RM), Italy; 1344 1356 University of Camerino, School of Pharmacy, Camerino, MC, Italy; 1345 1357 University of Oviedo, Principality of Asturias Institute for Biomedical Research, Department of Functional Biology, Oviedo, Spain; 1346 1358 Washington University in St. Louis, Department of Biology, St. Louis, MO, USA; 1347 1359 UMBC, Department of Chemical, Biochemical and Environmental Engineering, Baltimore, MD, USA; 1348 1360 University of Vienna, Max Perutz Labs, Department of Biochemistry and Cell Biology, Vienna BioCenter, Vienna, Austria; 1349 1361 Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology, Boston, MA, USA; 1350 1362 European Institute of Oncology (IEO) IRCCS, Department of Experimental Oncology, Milan, Italy; University of Milano, Department of Oncology and Hemato-Oncology, Milan, Italy; 1351 1363 KU Leuven, Department of cellular and Molecular Medicine, Laboratory of cellular transport systems, Leuven, Belgium; 1352 1364 Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Department of Biotechnology, Madrid, Spain; 1353 257 Laboratorio de Genética Bioquímica (LAGENBIO), Centro de Encefalopatías y Enfermedades Transmisibles Emergentes, Instituto Agroalimentario de Aragón-IA2, Instituto de Investigación Sanitaria Aragón-IISA, Universidad de Zaragoza, Zaragoza, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, Zaragoza, Spain; 1354 1365 University of Las Palmas de Gran Canaria, Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), Las Palmas de Gran Canaria, Spain; 1355 1366 Instituto de Investigaciones Biomédicas “Alberto Sols”, CSIC-UAM, Madrid, Spain; 1356 1660 Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA; 1357 2108 University of Cambridge, MRC Mitochondrial Biology Unit, Cambridge, UK; 1358 1367 National Institutes of Health, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; 1359 1368 Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, AC, Unidad de Biotecnología Médica y Farmacéutica, Guadalajara, Jalisco, México; 1360 1369 Albert Einstein College of Medicine, Radiation Oncology, Bronx, NY, USA; 1361 1370 Vall d\'Hebron research Institute-UAB/Neurodegenerative Diseases Group, Barcelona, Spain; 1362 1371 University of São Paulo, Institute of Biomedical Sciences, Department of Anatomy, Laboratory of Functional Neuroanatomy of Pain, São Paulo, Brazil; 1363 1372 Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, University of São Paulo, São Paulo, Brazil; 1364 1373 Universidade Anhanguera de São Paulo, Programa de Pós-graduação Stricto sensu e Pesquisa, São Paulo, Brazil; 1365 1374 Università Cattolica del Sacro Cuore, Rome, Italy;299 Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS, Rome, Italy; 1366 1375 Institut Jean-Pierre Bourgin, INRAE, AgroParisTech, Université Paris-Saclay, 78000 Versailles, France; 1367 1376 University of Minnesota, Department of Biochemistry, Molecular Biology and Biophysics and Department of Medicine, Minneapolis, MN, USA; 1368 1377 Università degli Studi di Milano, Dipartimento di Scienze della Salute, Milano, Italy; 1369 1378 Universidad Nacional Autónoma de México, Instituto de Fisiología Celular, División de Neurociencias, Departamento de Neuropatología Molecular, Mexico, DF, Mexico; 1370 1379 MRC Laboratory of Molecular Biology, Cambridge, UK; 1371 1380 University of Rome “Sapienza”, Department of Experimental Medicine, Rome, Italy; 1372 1339 Center for gender-specific medicine, Italian National Health Institute, Rome, Italy; 1373 1381 Biodonostia Health Research Institute, group of Cellular Oncology; IKERBASQUE; CIBERfes, Spain; 1374 1382 Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Department of Cardiovascular Medicine, Kyoto, Japan; 1375 1383 CHU Clermont-Ferrand, Chirurgie Gynécologique, Clermont-Ferrand, France; Université Clermont Auvergne, Institut Pascal, UMR6602, CNRS/UCA/SIGMA, Clermont-Ferrand, France; 1376 1384 University of Chieti-Pescara, Department of Medical, Oral, and Biotechnological Science, Chieti, Italy; 1377 46 Metabolism and Cancer Laboratory, Molecular Mechanisms and Experimental Therapy in Oncology Program (Oncobell), Institut d\'Investigació Biomèdica de Bellvitge - IDIBELL, L\'Hospitalet de Llobregat, Barcelona, Spain; 1378 1385 University of California, Davis, Department of Dermatology, Sacramento, CA, USA; 1379 1386 CONACYT - Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Puebla, Mexico; 1380 975 Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Solna, Stockholm, Sweden; 1381 1387 IRCCS “Casa Sollievo della Sofferenza”, Opera di Padre Pio da Pietrelcina, Division of Internal Medicine and Chronobiology Unit, Department of Medical Sciences, San Giovanni Rotondo (FG), Italy; 1382 1388 Sapienza University of Rome, Department of Biology and Biotechnology (C. Darwin), Rome, Italy; 1383 1390 University of Texas Health Science Center at Houston, Center for Stem Cell and Regenerative Disease, Institute of Molecular Medicine (IMM), Houston, TX, USA; 1384 1391 Cleveland Clinic, Lerner Research Institute, Department of Inflammation & Immunity, Cleveland, OH, USA; 1385 1392 University of Arkansas for Medical Sciences, Fay W. Boozman College of Public Health, Department of Environmental and Occupational Health, Little Rock, AR, USA; 1386 1393 University College Cork, Department of Cancer Research, Cork, Ireland; 1387 1394 Academic Decency, MeTooSTEM, Nashville, TN, USA; 1388 1395 Mayo Clinic, Rochester, MN, USA; 1389 1396 Translational Stem Cell Biology Metabolism Program, Research Programs Unit, University of Helsinki, Helsinki, Finland;2318 Department of Anatomy, Faculty of Medicine, Helsinki, Finland; 1390 1397 PSL Research University, Equipe labelisée par la Ligue Contre le Cancer, Institut Curie, Inserm, U830, Stress and Cancer laboratory, Paris, France; 1391 793 Max Planck Institute for Biology of Ageing, Cologne, Germany; University of Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany;804 Max Planck Institute for Biology of Ageing, Cologne, Germany; 1392 1398 Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, and University of Ottawa, Department of Medicine, Ottawa, ON, Canada; 1393 1399 University of Szeged, Department of Medical Microbiology and Immunobiology, Szeged, Hungary; 1394 1400 University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, USA; 1395 1401 University of Amsterdam, Medical Biochemistry, Amsterdam UMC, Amsterdam, The Netherlands; 1396 1402 Leiden University, Institute of Biology Leiden, Leiden, The Netherlands; The City University of New York, Queens College, The Graduate Center of the City University of New York, Department of Biology, Flushing, NY, USA; 1397 1403 UiT The Arctic University of Norway, Department of Pharmacy, Pharmacology Research Group, Tromso, Norway; 1398 1404 Childrens\' Hospital, Hannover Medical School, Hannover, Germany; 1399 1406 Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China; University of Science and Technology of China, Anhui, China; 1400 1407 Laboratory of Cell Biology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil; 1401 1408 Indian Institute of Technology Delhi, Kusuma School of Biological Sciences, New Delhi, India; 1402 1409 University of Cincinnati, Division of Hematology/Oncology, Cincinnati, OH, USA; 1403 1410 University of Pretoria, School of Medicine, Faculty of Health Sciences, Department of Physiology, Pretoria, South Africa; 1404 1411 Laboratoire d\'Optique et Biosciences, Ecole Polytechnique, CNRS, Inserm, Institut Polytechnique de Paris, Palaiseau, France; 1405 1412 University of New Mexico, Clinical and Translational Sciences Center, Albuquerque, NM, USA; 1406 1413 Carité-Universitaetsmedizin Berlin, Campus Mitte, Institut für Integrative Neuroanatomie, Berlin, Germany; 1407 1414 Ruprecht-Karls University of Heidelberg, Women\'s Hospital, Department of Gynecological Endocrinology and Fertility Disorders, Heidelberg, Germany; 1408 1415 Institut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Université Paris-Saclay, Versailles, France; 1409 1416 University of Duisburg-Essen, Centre for Medical Biotechnology, Faculty of Biology, Essen, Germany; 1410 1417 Tianjin Medical University, Department of Immunology, School of Basic Medical Sciences, Tianjin, China; 1411 1418 INSERM Institute of Metabolic and Cardiovascular Diseases (I2MC), Université de Toulouse, Toulouse, France; 1412 1419 Shandong University, School of Life Science, Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Qingdao, China; 1413 1420 Fondazione IRCCS Casa Sollievo della Sofferenza, Poliambulatorio (Giovanni Paolo II), Division of Medical Genetics, San Giovanni Rotondo (FG), Italy; 1414 1421 Hirosaki University Graduate School of Medicine, Institute of Brain Science, Department of Neuropathology, Hirosaki, Japan; UCL Queen Square Institute of Neurology, Queen Square Brain Bank for Neurological Disorders, London, UK; 1415 1423 National Medicines Institute, Department of Drug Biotechnology and Bioinformatics, Warszawa, Poland; 1416 1424 University of Washington School of Medicine, Department of Biochemistry, Seattle, WA, USA; 1417 1425 University of Washington, Departments of Medicine, Microbiology and Genome Sciences, Seattle, WA, USA; 1418 1426 Sage Therapeutics, Cambridge, MA, USA; 1419 1427 European Neuroscience Institute (ENI) - A Joint Initiative of the University Medical Center Göttingen and the Max Planck Society, Göttingen, Germany; 1420 523 Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Department of Molecular Sciences, Uppsala BioCenter, Uppsala, Sweden; Heidelberg University, Center for Organismal Studies, Neuenheimer Feld, Heidelberg, Germany; 1421 1428 Kashan University of Medical Sciences, Research Center for Biochemistry and Nutrition in Metabolic Disease, Kashan, Iran; 1422 1429 Tehran University of Medical Sciences, School of Medicine, Department of Medical Immunology, Tehran, Iran; 1423 826 Macquarie University, Faculty of Medicine and Health Sciences, New South Wales, Australia; 1424 1431 Indian Institute of Technology Jodhpur, Cellular and Molecular Neurobiology Unit, Jodhpur, Rajasthan, India; 1425 1432 Amrita Vishwa Vidyapeetham, School of Biotechnology, Kollam, Kerala, India; 1426 1433 University of Nebraska Medical Center, Department of Cellular and Integrative Physiology, Omaha, NE, USA; 1427 1434 University of Campania (L. Vanvitelli), Department of Precision Medicine, Naples, Italy; Institute of Genetic Research, Biogem scarl, Laboratory of Molecular and Precision Oncology, Ariano Irpino (AV), Italy;1435 University of Campania “Luigi Vanvitelli”, Department of Precision Medicine, Naples, Italy; 1428 1436 Université Toulouse III, Toulouse, France; 1429 1437 Sapporo Medical University, Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo, Japan; 1430 1438 University of California San Diego, Department of Pharmacology, La Jolla, CA, US; 1431 1439 University of Colorado Denver, Department of Medicine, Aurora, CO, USA; 1432 1440 Health Sciences University of Hokkaido, College of Rehabilitation Sciences, Department of Physical Therapy, Ishikari-Tobetsu, Hokkaido, Japan; 1433 1441 Nagasaki University Graduate School of Biomedical Sciences, Department of Infectious Diseases, Nagasaki, Japan; 1434 1442 Tokyo Medical University, Department of Biochemistry, Tokyo, Japan; 1435 1443 The University of Tokyo, Department of Biochemistry and Molecular Biology, Graduate School of Medicine, Tokyo, Japan; 1436 1444 Aarhus University, Department of Biomedicine, Aarhus, Denmark; 1437 1108 Université Côte d\'Azur (UCA), Institute for Research on Cancer and Aging of Nice (IRCAN), Centre Antoine Lacassagne, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Fédération Hospitalo-Universitaire (FHU) OncoAge, Nice, France; 1438 1445 Kerman University of Medical Sciences, Institute of Neuropharmacology, Pharmaceutics Research Center, Kerman, Iran; 1439 1446 MVR Cancer Hospital and Research Institute, Molecular Oncology, Cancer Genomics/Proteomics, Kerala, India; 1440 1447 University of Kaiserslautern, Department of Biology, Plant Physiology, Kaiserslautern, Germany; 1441 1448 International Centre for Genetic Engineering and Biotechnology, New Delhi, India; 1442 1449 Department of Experimental Pathology, Institute of Biomedical Research of Barcelona, Spanish Research Council (IIBB-CSIC); IDIBAPS and CIBEREHD, Barcelona, Spain; 1443 1450 Washington University in St. Louis, Professor of Obstetrics and Gynecology, St. Louis, MO, USA; 1444 1451 Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Bellinzona, Switzerland; School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 1445 1452 University “Magna Graecia” of Catanzaro, Department of Health Sciences, Catanzaro, Italy; 1446 1453 Aarhus University Hospital, Steno Diabetes Center Aarhus, Aarhus, Denmark; Aarhus University, Department of Clinical Medicine, Research Laboratory for Biochemical Pathology, Aarhus, Denmark; 1447 1454 Université de Lyon, ENSL, UCBL, CNRS, LBMC, UMS 3444 Biosciences Lyon Gerland, Lyon, France; 1448 1455 Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Department of Molecular Biomedicine, Laboratory of Cell Death and Cancer Therapy, Madrid, Spain; 1449 1456 Bispebjerg Hospital, Institute of Sports Medicine Copenhagen, Copenhagen,Denmark; UniCamillus, Saint Camillus International University of Health Sciences, Rome, Italy; 1450 1457 University of Maryland School of Medicine, Center for Biomedical Engineering and Technology, Baltimore, MD, USA; 1451 1458 Università degli Studi di Sassari, Dipartimento di Scienze Biomediche, Sassari, Italy; 1452 1460 Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Immunopathology and Cancer Biomarkers, Aviano, Italy; 1453 1461 University of Virginia, Department of Biology, Charlottesville, VA, USA; 1454 1462 University of Exeter Medical School, European Centre for Environment & Human Health (ECEHH), Knowledge Spa, Royal Cornwall Hospital, Truro, Cornwall, UK; Plymouth Marine Laboratory (PML), Plymouth, UK; University of Plymouth, School of Biological & Marine Sciences, Plymouth, UK; 1455 1463 National Institute of Genetic Engineering and Biotechnology, Institute of Medical Biotechnology, Molecular Medicine Department, Tehran, Iran; 1456 1464 University of Pittsburgh, Department of Medicine, Aging Institute, Pittsburgh, PA, USA; 1457 1465 Fondazione IRCCS Istituto Neurologico Carlo Besta, Neuromuscular Diseases and Neuroimmunology Unit, Milano, Italy; 1458 296 University of Las Palmas de Gran Canaria, Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), Las Palmas de Gran Canaria, Spain; Norwegian School of Sport Sciences, Department of Physical Performance, Oslo, Norway;1365 University of Las Palmas de Gran Canaria, Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), Las Palmas de Gran Canaria, Spain; 1459 1466 University of Coimbra, Institute of Physiology, Faculty of Medicine, Coimbra, Portugal and CNC - Center for Neuroscience and Cell Biology, Coimbra, Portugal; 1460 1467 European Institute of Oncology (IEO) IRCCS, Department of Experimental Oncology, Milan, Italy; 1461 457 University Roma Tre, Department of Science, LIME, Rome, Italy;1459 Laboratory of Neurodevelopment, Neurogenetics and Molecular Neurobiology, IRCCS Fondazione Santa Lucia, Rome, Italy; 1462 1468 National Autonomous University of Mexico (UNAM), Department of Neurodevelopment and Physiology, Institute of Cellular Physiology, Mexico City, Mexico; 1463 1469 Sapienza University of Rome, Department of Anatomy, Histology, Forensic Medicine & Orthopedics, Histology & Medical Embryology Section, Rome, Italy; 1464 1470 Ifremer, SG2M-LGPMM, Laboratoire de Génétique et Pathologie des Mollusques Marins, La Tremblade, France; 1465 1471 Swansea University Medical School, Molecular Neurobiology group, Swansea, United Kingdom; 1466 1472 Normandie University, UNIROUEN, INSERM U1239, DC2N, Rouen, France; Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France; 1467 1473 Juntendo University Graduate School of Medicine, Department of Physiology, Tokyo, Japan; 1468 1474 University of British Columbia, Department of Ophthalmology and Visual Sciences, Vancouver, British Columbia, Canada; 1469 1475 Kindai University, Pharmaceutical Research and Technology Institute, Higashi-Osaka, Osaka, Japan; 1470 1476 Saitama University, Department of Regulatory Biology, Saitama, Japan; 1471 1477 Pontificia Universidad Católica de Chile, Faculty of Biological Sciences, Department of Physiology, Santiago de Chile, Chile; 1472 1993 The University of Texas McGovern Medical School at Houston, Department of Neurology, Houston, TX, USA; 1473 1479 Weill Cornell Medicine, Rockefeller University Campus, Department of Pathology and Laboratory Medicine, New York, NY, USA; 1474 1480 Max Planck Institute for the Biology of Ageing, Cologne, Germany; 1475 1481 Federal University of Ceara, Drug Research and Development Center, Fortaleza, CE, Brazil; 1476 1482 Texas Tech University, Department of Nutritional Sciences & Obesity Research Institute, Lubbock, TX, USA; 1477 1483 University of Münster, Institute of Medical Microbiology, Münster, Germany; 1478 1484 Indian Council of Medical Research - National AIDS Research Institute, Division of Molecular Virology, Pune, MH, India; 1479 1485 New York University Medical School, Laura and Isaac Perlmutter Cancer Center, Department of Radiation Oncology, New York, NY, USA; 1480 1486 University of Colorado Denver, Children\'s Hospital Colorado, Morgan Adams Foundation Pediatric Brain Tumor Research Program, Aurora, CO; 1481 1487 CNRS Biotechnology and cell signaling, Ecole Supérieure de Biotechnologie de Strasbourg, Strasbourg University/Laboratory of excellence Medalis; University of Strasbourg Institute for Advanced Study, Strasbourg, France; 1482 1488 ICREA, Pompeu Fabra University (UPF), Department of Experimental and Health Sciences, Ciberned, Barcelona, Spain; Spanish National Cardiovascular Research Center (CNIC), Madrid, Spain; 1483 1489 National Hospital for Paraplagics (Sescam) Research Unit, Molecular Neuroprotection Group, Toledo, Spain; 1484 1490 University of Zürich, Institute of Experimental Immunology, Viral Immunobiology, Zürich, Switzerland; 1485 1491 King\'s College London, School of Cardiovascular Medicine and Sciences, London, UK; 1486 1492 Old Dominion University, Frank Reidy Research Center for Bioelectrics, Norfolk, VA, USA; 1487 1493 Royal College of Surgeons in Ireland, Department of Physiology & Medical Physics, Dublin 2, Ireland; 1488 1494 University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada; 1489 1495 Genentech, Inc. Department of Cancer Immunology, South San Francisco, CA, USA; 1490 1496 University of Helsinki, Faculty of Pharmacy, Division of Pharmacology and Pharmacotherapy/Drug Research Program, Helsinki, Finland; 1491 1497 Washington University School of Medicine, Department of Obstetrics and Gynecology, and Department of Pathology and Immunology, St. Louis, MO, USA; 1492 1498 University of Rzeszow, Institute of Biology and Biotechnology, Department of Biotechnology, Rzeszow, Poland; 1493 1499 Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, P.O. Box 19395-5487, Iran.; 1494 1500 Cornell University, Department of Entomology, Ithaca, NY, USA; 1495 1501 Rutgers-New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Newark, NJ, USA; 1496 1502 University Hospital of Lausanne, Central Laboratory of Hematology, Lausanne, Switzerland; 1497 1503 Kyoto University, Department of Microbiology, Graduate School of Medicine, Kyoto, Japan; 1498 1504 Gladstone Institute of Neurological Disease and University of California, San Francisco, Department of Neurology, San Francisco, CA, USA; 1499 1505 Tokyo Institute of Technology, School of Life Science and Technology, Yokohama, Japan; 1500 1506 University of South Florida, Department of Cell Biology, Microbiology, and Molecular Biology, Tampa, FL, USA; 1501 1507 “Sapienza” University of Rome, Department of Clinical and Molecular Medicine, Laboratory affiliated to Istituto Pasteur Italia Fondazione Cenci Bolognetti, Rome, Italy; 1502 1509 University of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, UK; 1503 1510 Soroka University Medical Center, Institute of Hematology and Ben-Gurion University of the Negev, Faculty of Health Sciences, Department of Clinical Biochemistry and Pharmacology, Beer-Sheva, Israel; 1504 1511 Niigata University, Brain Research Institute, Department of Neurosurgery, Niigata, Japan; 1505 1512 Nelson Mandela University, Department of Biochemistry and Microbiology, Port Elizabeth, South Africa; 1506 1513 Ecole Polytechnique Fédérale de Lausanne (EPFL), Institute of Bioengineering (IBI) and Swiss Institute for Experimental Cancer Research (ISREC), Laboratory of Regenerative Hematopoiesis, Lausanne, Switzerland; Centre Hospitalier Universitaire Vaudois (CHUV), Departments of Oncology and Laboratory Medicine, Hematology Service, Lausanne, Switzerland; 1507 1514 University of Arizona, Department of Medicine, Tucson, AZ, USA; 1508 1515 Georgia State University, Department of Biology, Atlanta, GA, USA; 1509 959 Lund University, Department of Experimental Medical Science, Laboratory of Molecular Neurogenetics, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund, Sweden;1693 University of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark; 1510 1516 Radboud University Medical Center, Department of Internal Medicine, Nijmegen, The Netherlands; 1511 1517 Maastricht University Medical Center, CARIM School for Cardiovascular Diseases, Department of Pathology, Maastricht, The Netherlands; 1512 1518 University Hospital Basel, Department of Biomedicine, Ocular Pharmacology and Physiology, Basel, Switzerland; 1513 1519 Karolinska Institutet, Department of Women\'s and Children\'s Health, Stockholm, Sweden; Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Solna, Sweden; 1514 1520 King\'s College London GKT School of Medical Education, London, UK; 1515 1521 The University of Sydney, Kolling Institute, Renal Medicine, Sydney, New South Wales, Australia; 1516 1522 University of Kansas Medical Center. Department of Pharmacology, Toxicology and Thereapeutics, Kansas City, KS, USA; 1517 1523 Trinity College Dublin, Department of Clinical Medicine, Trinity Centre for Health Sciences, Dublin, Ireland; 1518 1524 Army Medical University (Third Military Medical University), Daping Hospital, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Laboratory for the Prevention and Rehabilitation of Military Training Related Injuries, Chongqing, China; 1519 1525 University of Ferrara, Department of Chemical and Pharmaceutical Sciences, Ferrara, Italy; 1520 1526 National Hospital for Paraplegics (SESCAM), Research Unit, Molecular Neuroprotection Group, Toledo, Spain; 1521 1527 East Tennessee State University, Quillen College of Medicine, Center of Excellence for Inflammation, Infectious Diseases, and Immunity, Department of Medicine, Johnson City, TN, USA; 1522 1528 ICMR-Vector Control Research Center, Unit of Microbiology and Immunology, Puducherry, India; 1523 1529 University of Kansas School of Medicine, Department of Anatomy and Cell Biology, Kansas City, KS, USA; 1524 1530 New York University School of Medicine, Departments of Psychiatry and Cell Biology, and the Nathan Kline Institute, Orangeburg, NY, USA; 1525 1532 Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Faro, Portugal; ABC-RI, Algarve Biomedical Center Research Institute, Faro, Portugal; Centre for Biomedical Research, Faro, Portugal; 1526 1533 Duke University, Department of Biology and Howard Hughes Medical Institute, Durham, NC, USA; 1527 1534 University of Split, School of Medicine, Split, Croatia; 1528 1535 Doshisha University Graduate School of Brain Science, Laboratory of Structural Neuropathology, Kyoto, Japan; 1529 1536 Center for Molecular Biology of Heidelberg University (ZMBH) and German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Heidelberg, Germany; 1530 1537 Danish Cancer Society Research Center, Unit for Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Copenhagen, Denmark; University of Copenhagen, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, Copenhagen N, Denmark; 1531 1538 Trinity College Dublin, Trinity Translational Medicine Institute, Dublin, Ireland; 1532 1539 David Geffen School of Medicine at UCLA, Department of Microbiology, Immunology, and Molecular Genetics, Los Angeles, CA, USA; 1533 1540 University of Messina, Sicily, Italy; 1534 1541 Hopp Children\'s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK), Clinical Cooperation Unit Pediatric Oncology, Im Neuenheimer Feld, Heidelberg, Germany; 1535 1542 National Institute of Infectious Diseases, Department of Bacteriology I, Toyama, Tokyo, Japan; 1536 1543 Université de Paris, Centre de recherche sur l\'inflammation, Team Gut Inflammation, Inserm, U1149, CNRS, ERL8252, Paris, France; 1537 1544 University of Iceland, Faculty of Medicine, Biomedical center, Reykjavik, Iceland; 1538 1545 Hollings Cancer Center, Department of Biochemistry and Molecular Biology, Charleston, SC, USA; 1539 1546 Ewha Womans University, Department of Life Science, Immune and Vascular Cell Network Research Center, National Creative Initiatives, Seoul, Korea; 1540 1547 Chosun University, School of Medicine, Gwangju, Korea; 1541 1548 Yonsei University, Wonju, Korea; 1542 1549 Yamaguchi University, Joint Faculty of Veterinary Medicine, Laboratory of Veterinary Pharmacology, Yoshida, Yamaguchi, Japan; 1543 1550 Hyogo College of Medicine, Department of Genetics, Hyogo, Japan; 1544 1551 University of Perugia, Department of Medicine and Surgery, Perugia, Italy; 1545 1552 Stanford University, School of Medicine, Department of Pathology, CA, USA; 1546 1553 Osaka University, Laboratory of Mitochondrial Dynamics, Graduate School of Frontier Biosciences, Osaka, Japan; 1547 1554 Tokyo Medical and Dental University, Tokyo, Japan.; 1548 1555 Kyoto University of Advanced Science, Faculty of Bioenvironmental Science, Kameoka, Kyoto, Japan; 1549 1556 University of Porto, REQUIMTE/UCIBIO, Faculty of Pharmacy, Porto, Portugal; 1550 1557 Amgen Inc., South San Francisco, CA, USA; 1551 1558 University of California, Berkeley, Departments of Molecular and Cell Biology and Nutritional Sciences and Toxicology, Berkeley, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA; 1552 1559 Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, NJ, USA; 1553 1560 University of Defense, Faculty of Military Health Sciences, Department of Radiobiology, Hradec Kralove, Czech Republic; 1554 1561 The Chinese University of Hong Kong, Lui Che Woo Institute of Innovative Medicine, Centre for Cardiovascular Genomics and Medicine (CCGM), Shatin, Hong Kong, China; The Chinese University of Hong Kong, Faculty of Medicine, Department of Medicine & Therapeutics, Shatin, Hong Kong, China; Hong Kong Hub of Paediatric Excellence (HK HOPE), Hong Kong Children’s Hospital, Kowloon, Hong Kong, China; Xiamen University, Xiamen Cardiovascular Hospital, Institute for Translational Medicine, Xiamen, China; Chinese Academy of Sciences, Kunming Institute of Zoology - The Chinese University of Hong Kong (KIZ-CUHK) Joint Laboratory of Bioresources and Molecular Research of Common Diseases, Kunming, Yunnan, China; 1555 1562 The University of Illinois at Chicago College of Medicine, Department of Pharmacology, Chicago, IL, USA; 1556 1563 Pontificia Universidad Católica de Chile, Escuela de Medicina and Centro Interdisciplinario de Neurociencias, Facultad de Medicina, Departamento de Neurología, Santiago, Chile; 1557 1564 University of Pennsylvania Perelman School of Medicine and Division of Neurology, The Children’s Hospital of Philadelphia, Department of Neurology, Philadelphia, PA, USA; 1558 1565 Suez Canal University, Faculty of Veterinary Medicine, Ismailia, Egypt; 1559 1567 University of Wisconsin-Madison, Center for Quantitative Cell Imaging and Department of Botany, Madison, WI, USA; 1560 1568 German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Molecular Toxicology, Nuthetal, Germany; 1561 1569 Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Institute of Molecular Bioimaging and Physiology (IBFM), CNR, Milan, Italy; 1562 1570 University of Southern California, Keck School of Medicine, Department of Molecular Microbiology and Immunology, Los Angeles, CA, USA; 1563 1571 University Medical Center Göttingen, Center for Biostructural Imaging of Neurodegeneration, Department of Experimental Neurodegeneration, Göttingen, Germany; Max Planck Institute for Experimental Medicine, Göttingen, Germany; Newcastle University, The Medical School, Institute of Neuroscience, Newcastle upon Tyne, UK; 1564 1572 Oslo University Hospital and University of Oslo, Department of Pathology, Tumor Immunology Lab, Oslo, Norway; 1565 1573 Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Medical Biology Department, Istanbul, Turkey; 1566 1574 Texas Biomedical Research Institute, Host-Pathogen Interactions Program, San Antonio, TX, USA; 1567 1575 Baylor College of Medicine, Department of Molecular and Human Genetics, Houston, TX, USA; 1568 1576 University of Naples Federico II, Department of Molecular Medicine and Medical Biotechnology, Naples, Italy; 1569 1577 Université de Paris, Centre de Recherche des Cordeliers, Paris, France; 1570 1578 Fondazione IRCCS Ospedale San Raffaele, Division of Neuroscience, Milan, Italy; 1571 1579 University of São Paulo, Department of Parasitology, São Paulo, Brazil; 1572 1580 University of Rome Tor Vergata, Department of Clinical Sciences and Translational Medicine, Rome, Italy; 1573 1581 Goethe University Frankfurt, Buchmann Institute for Molecular Life Sciences (BMLS), Frankfurt am Main, Germany; 1574 1582 Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China; 1575 1583 Affiliated Hospital of GuangDong Medical University, Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City, Zhanjiang, Guangdong, China; 1576 1584 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 1577 1585 National Center of Biomedical Analysis, Beijing, China; 1578 1587 The Children\'s Hospital of Philadelphia, Center for Applied Genomics, Philadelphia, PA, USA; 1579 1588 University of Pittsburgh Medical Center, Department of Pediatrics, Pittsburgh, PA, USA; 1580 1589 University of Alberta, Department of Biochemistry, Edmonton, Canada; 1581 1590 University of Salento, Department of Biological and Environmental Sciences and Technologies (Di.S.Te.B.A.), Lecce, Italy; 1582 1591 Danish Cancer Society Research Center, Computational Biology Laboratory, Copenhagen, Denmark; 1583 1592 Max Perutz Labs, University of Vienna, Vienna Biocenter (VBC), Vienna, Austria; 1584 1593 Quadram Institute Bioscience, Department of Gut, Microbes and Health, Norwich, UK; 1585 1594 Waksman Institute, Department of Genetics, Rutgers University, Piscataway, NJ, USA; 1586 1595 Dong-A University Medical School, Department of Molecular Neuroscience, Busan, Korea; 1587 1596 Medical College of Wisconsin, Department of Biochemistry, Milwaukee, WI, USA; 1588 1597 Incheon National University, Division of Life Sciences, College of Life Sciences and Bioengineering, Incheon, Korea; 1589 1598 Yonsei University, Division of Biological Science and Technology, Wonju, Korea; 1590 1599 Chonnam National University, The Future Life & Society Research Center, Gwangju, Korea; 1591 1600 Chonbuk National University, Department of VeterinaryMedicine, Iksan, Korea; 1592 1601 Ben Gurion University of the Negev, Department of Chemistry, Be\'er Sheva, Israel; 1593 1602 KU Leuven, Department of Cellular and Molecular Medicine & Leuven Kanker Instituut, Leuven, Belgium; 1594 1603 Sanofi, Vitry Sur Seine, France; 1595 1604 Mayo Clinic, Department of Physiology and Biomedical Engineering, Rochester, MN, USA; 1596 58 Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Naples, Italy;133 Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy; Baylor College of Medicine, Houston, TX, USA;134 University of Naples Federico II, Department of Translational Medical Sciences, Naples, Italy; 1597 1605 VA San Diego Healthcare Systems and University of California, San Diego, Department of Anesthesiology, La Jolla, CA, USA; 1598 1606 Internal Medicine 1, Brandenburg Hospital, Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus Senftenberg, the Brandenburg Medical School Theodor Fontane and the University of Potsdam, Brandenburg, Germany; 1599 1607 IRCM, Institut de Recherche en Cancérologie de Montpellier, Tumor Microenvironment and Resistance to Treatment Laboratory, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, Montpellier, France; 1600 1608 Universidad Nacional Autónoma de México, Instituto de Biotecnología, Departamento de Medicina Molecular y Bioprocesos, Laboratorio de Neuroinmunobiología, Cuernavaca, Morelos, México; 1601 1609 Universidad de Chile, School of Medicine, Instituto de Ciencias Biomédicas, Santiago de Chile, Chile; 1602 1610 Friedrich-Loeffler-Institut, Insitute of Immunology, Greifswald - Insel Riem, Germany; 1603 1611 The Fourth Military Medical University, National Key Discipline of Cell Biology, Department of Physiology and Pathophysiology, Xi’an, Shaanxi, China; 1604 1612 Weizmann Institute of Science, Department of Plant and Environmental Sciences, Rehovot, Israel; 1605 1613 Centro de Investigaciones Biológicas CSIC, Department of Cellular and Molecular Biology, Madrid, Spain; 1606 1614 Sun Yat-Sen University, Sun Yat-sen Memorial Hospital, Department of Neurology, Guangzhou City, Guangdong, China; 1607 1615 University of Padova, Department of Biomedical Sciences, Padova, Italy; 1608 1616 Fondazione G. Pascale, Istituto Nazionale Tumori IRCCS, Cell Biology and Biotherapy Unit, Naples, Italy; 1609 1617 University of Coimbra, CNC – Center for Neuroscience and Cell Biology & Faculty of Medicine & CIBB – Center for Innovative Biomedicine and Biotechnology, Coimbra, Portugal; 1610 1618 Universidade Federal de São Paulo, Paulista School of Medicine, Departament of Pharmacology, São Paulo, Brazil; 1611 1619 São Paulo State University, College of Agronomy Sciences, Department of Bioprocesses and Biotechnology, Center for Evaluation of Environmental Impact on Human Health (TOXICAM), Botucatu, SP, Brazil; 1612 1620 University of Melbourne, Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; 1613 1621 University of Granada, Faculty of Pharmacy, Department of Physical Chemistry, Granada, Spain; 1614 1622 University of Nebraska Medical Center, Department of Pharmacology and Experimental Neuroscience, Omaha, NE, USA; 1615 1623 State University of New York, Upstate Medical University, Departments of Medicine, Microbiology and Immunology, Biochemistry and Molecular Biology, Syracuse, NY, USA; 1616 1624 Università degli Studi di Milano, Department of Biomedical and Clinical Sciences “L. Sacco”, Milan, Italy; 1617 1625 University of Calabria, Department of Biology, Ecology and Earth Sciences, Centre for Microscopy and Microanalysis (CM2), Rende (CS), Calabria, Italy; 1618 1626 Baruch S. Blumberg Institute, Pennsylvania Cancer and Regenerative Medicine Research Center, Wynnewood, PA, USA; Xavier University School of Medicine, Woodbury, NY, USA; 1619 1627 National Jewish Health and the University of Colorado, Denver, CO, USA; 1620 1628 University of Oslo, Oslo University Hospital and Institute for Clinical Medicine, Department of Ophthalmology, Center for Eye Research, Oslo, Norway; 1621 1629 Health and Medical University, Potsdam, Germany; 1622 1630 Ulm University, Institute of Biochemistry and Molecular Biology, Faculty of Medicine, Ulm, Germany; 1623 1631 Washington University, Division of Infectious Diseases, Department of Medicine and Molecular Microbiology, St. Louis, MO, USA; 1624 1632 Third Military Medical University, Department of Occupational Health, Chongqing, China; 1625 1633 Virginia Polytechnic Institute and State University, School of Neuroscience, Blacksburg, VA, USA; 1626 1634 Aix Marseille Université, CNRS, INSERM, CIML, 13288 Marseille cedex 9, France; Institute for Research in Biomedicine (iBiMED) and Ilidio Pinho Foundation, Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal; Shanghai Institute of Immunology, Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China; 1627 1635 Karolinska Institutet, Department of Biosciences and Nutrition, Huddinge, Sweden; 1628 134 University of Naples Federico II, Department of Translational Medical Sciences, Naples, Italy; 1629 1636 Consejo Superior de Investigaciones Científicas (CSIC), Instituto de Biología Molecular y Celular del Cáncer (IBMCC), Centro de Investigación del Cáncer (CSIC-Universidad de Salamanca), Universidad de Salamanca, Campus Unamuno, Salamanca. Spain; 1630 1637 Tel Aviv University, School of Neurobiology, Biochemistry and Biophysics, Tel Aviv, Israel; 1631 1638 The University of Texas MD Anderson Cancer Center, Department of Leukemia, Houston, TX, USA; 1632 1639 Radboud University Medical Center, Nijmegen, The Netherlands; 1633 1640 Ruhr-Universität Bochum, Medizinische Fakultät, Biochemie Intrazellulärer Transportprozesse, Bochum, Germany; 1634 2310 Achucarro Basque Center for Neuroscience, Department of Pharmacology, University of the Basque Country EHU/UPV, Leioa, Bizkaia, Spain; 1635 1642 University of Cologne, Center for Biochemistry, Cologne, Germany; 1636 1643 Moscow State University, A.N.Belozersky Institute of Physico-Chemical Biology, Laboratory of Structure and function of mitochondria, Moscow, Russia; 1637 1644 UCL Queen Square Institute of Neurology, London, UK; 1638 1645 Monash Biomedicine Discovery Institute and Monash University, Department of Anatomy and Developmental Biology, Melbourne, Victoria, Australia; 1639 1646 Georg-August University Göttingen, Institute of Microbiology and Genetics, Department of Genetics of Eukaryotic Microorganisms, Göttingen, Germany; 1640 1647 Buchmann Institute & Institute of Biochemistry II, Medical Faculty, Goethe University, Frankfurt, Germany; 1641 1648 Cancer Research Center of Toulouse, UMR 1037 Inserm-university of Toulouse, Toulouse, France; 1642 1649 Mahidol University, Department of Microbiology, Faculty of Science, Ratchathewi, Bangkok, Thailand; 1643 1650 Erasmus University Medical Center, Department of Epidemiology; Division of Pharmacology, Department of Internal Medicine, Rotterdam, The Netherlands; 1644 1651 The Hospital for Sick Children, Translational Medicine Program, Toronto, Canada; 1645 1652 St. Jude Children’s Research Hospital, Department of Cell and Molecular Biology, Memphis, TN, USA; 1646 1653 University of Oxford, Nuffield Department of Women\'s and Reproductive Health, Oxford, UK; 1647 1654 University of California, Davis, Department of Molecular and Cellular Biology, Davis, CA, USA; 1648 1655 University of Iowa, Department of Biology, Aging Mind and Brain Initiative, Iowa City, IA, USA; 1649 1656 Temple University, Alzheimer\'s Center at Temple, Philadelphia, PA, USA; 1650 1657 Eberhard Karls University Tübingen, Interfaculty Institute of Cell Biology, Tübingen, Germany; 1651 1658 University of Cyprus, Department of Biological Sciences, Bioinformatics Research Laboratory, Nicosia, Cyprus; 1652 1659 Lifelong Health, South Australian Health & Medical Research Institute, North Terrace, Adelaide, Australia; 1653 1661 University of Wisconsin-Madison, Department of Medicine and Neuroscience, Madison, WI, USA; 1654 1662 Dalhousie University, Department of Biochemistry and Molecular Biology, Dalhousie Medicine New Brunswick, Saint John, NB, Canada; 1655 1663 National Center for Cell Science, Pune, India; 1656 763 Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland;1531 CURML, University Center of Legal Medicine, Lausanne University Hospital, Lausanne, Switzerland; 1657 1664 Chinese Academy of Sciences, Kunming Institute of Zoology, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming, Yunnan, China; 1658 1665 Lanzhou University, School of Life Sciences, Lanzhou, China; 1659 1666 Zhejiang University, College of Medicine, The First Affiliated Hospital, Malignant Lymphoma Diagnosis and Therapy Center, Hangzhou, Zhejiang, China; 1660 1667 China Pharmaceutical University, School of Basic Medicine and Clinical Pharmacy, State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Nanjing, China; 1661 1668 Sanofi, Biologics Research, 49 New York Ave, Framingham, MA, USA; 1662 1669 University of Waterloo, Department of Kinesiology, Waterloo, Ontario, Canada; 1663 1670 Instituto de Investigaciones Biomedicas en Retrovirus y Sida, Universidad de Buenos Aires-CONICET, Argentina; 1664 1672 University of Pittsburgh, Department of Pathology; University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA; 1665 1673 Dartmouth College, Department of Chemistry, Hanover, NH, USA; 1666 1674 Boston University, Department of Pathology and Laboratory Medicine, Boston, MA, USA; 1667 1675 Tehran University of Medical Sciences, Cancer Biology Research Center, Tehran, Iran; 1668 1676 Penn State University College of Medicine, Department of Cellular and Molecular Physiology, Hershey, PA, USA; 1669 1677 University of Alabama at Birmingham, Cardiac Aging & Redox Signaling Laboratory, Molecular and Cellular Pathology, Department of Pathology, Birmingham, AL, USA; 1670 1678 Johann Wolfgang Goethe-University, Institute of Anatomy III- \'Cellular and Molecular Anatomy\', Frankfurt, Germany; 1671 1679 University of Birmingham, Institute of Metabolism and Systems Research, Birmingham, UK; 1672 1680 MRC Laboratory of Molecular Biology, Division of Protein and Nucleic Acid Chemistry, Cambridge, UK; 1673 1681 Indian Institute of Science, Department of Biochemistry, Bangalore, India; 1674 1682 School of Medicine, the Southern University of Science and Technology, Shenzhen, China; 1675 1683 Baylor College of Medicine, Department of Medicine, Houston, TX, USA; 1676 1684 The University of Kansas Cancer Center, Division of Hematologic Malignancies and Cellular Therapeutics, Kansas City, KS, USA; 1677 1685 All India Institute of Medical Sciences, Department of Biotechnology, New Delhi, India; 1678 1686 University of Southampton, Clinical and Experimental Sciences, Faculty of Medicine, UK; 1679 1687 Johns Hopkins University School of Medicine, Department of Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Research Division, Baltimore, MD, USA; 1680 1688 University of South Carolina School of Medicine, Department of Pathology, Microbiology, and Immunology, Columbia, SC, USA; 1681 1689 Washington University School of Medicine, Department of Medicine, Cardiovascular Division,l and John Cochran VA Medical Center, St. Louis, MO, USA; 1682 1690 Johns Hopkins University, Bloomberg School of Public Health, Biochemistry and Molecular Biology Department, Baltimore, MD, USA; 1683 1691 Johannes Gutenberg University-Mainz, Institute of Developmental Biology and Neurobiology, Mainz, Germany; 1684 1692 Heinrich Heine University Düsseldorf, Medical faculty, Institute of Biochemistry and Molecular Biology I, Düsseldorf, Germany; 1685 1694 The University of Texas MD Anderson Cancer Center, Institute for Applied Cancer Science (IACS), Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION), Houston, TX, USA; 1686 1695 Max Planck Institute of Psychiatry, Translational Research in Psychiatry, Munich, Germany; 1687 1696 University of Vienna, Cell Imaging and Ultrastructure Research (CIUS), Vienna, Austria; 1688 1697 Karolinska Institutet, Department of Laboratory Medicine, Division of Clinical Microbiology, Stockholm, Sweden; 1689 1698 Wright State University, Department of Biochemistry & Molecular Biology, Dayton, OH. USA; 1690 1699 University of Wyoming, College of Health Sciences, Laramie, WY, USA; 1691 1700 Qingdao Agricultural University, College of Plant Health and Medicine, Qingdao, Shandong, China; 1692 2312 Ifremer, RBE, Département Ressources, La Tremblade, France; 1693 1702 University of California, Los Angeles, David Geffen School of Medicine, Department of Human Genetics, Los Angeles, CA, USA; 1694 1703 Botucatu Medical School, São Paulo State University, Botucatu, SP, Brazil; 1695 1704 Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; 1696 1705 The Ohio State University, College of Veterinary Medicine, Department of Veterinary Biosciences, Columbus, OH, USA; 1697 1706 Thomas Jefferson University, Department of Orthopaedic Surgery and Graduate Program in Cell Biology and Regenerative Medicine, Philadelphia, PA, USA; 1698 1707 Josep Carreras Leukaemia Research Institute, Barcelona, Spain; 1699 1708 Democritus University of Thrace, First Department of Internal Medicine & Laboratory of Molecular Hematology, Alexandroupolis, Greece; 1700 1709 Redox Signaling and Oxidative Stress group, Danish Cancer Society Research Center, Copenhagen, Denmark; 1701 1710 University of Padua, Department of Biomedical Sciences, Padua, Italy; 1702 1711 Middlesex University, Department of Natural Sciences, London, UK; 1703 1712 INSERM U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), Nice, France; Université de Nice Sophia Antipolis, UFR de Médecine, Nice, France; 1704 1713 Baylor College of Medicine, Department of Molecular Physiology & Biophysics, Houston, TX, USA; 1705 1714 Federal University of ABC (UFABC), Center for Natural and Human Sciences (CCNH), Santo André, SP, Brazil; 1706 1715 University of Campinas (UNICAMP), School of Applied Science, Department of Sport Sciences, Limeira, Brazil; 1707 1716 University of Barcelona, School of Medicine, Unit of Anatomy, Department of Pathology and Experimental Therapeutics, Barcelona, Spain; L\'Hospitalet de Llobregat, Institut d\'Investigació Biomèdica de Bellvitge -IDIBELL, Molecular Mechanisms and Experimental Therapy in Oncology Program (oncobell), Barcelona, Spain; 1708 1717 Kansas City University of Medicine and Biosciences, Department of Basic Science, Kansas City, MO, USA; 1709 1718 Goethe University Frankfurt, Institute of Pharmaceutical Chemistry, Frankfurt am Main, Germany; 1710 1719 University of Gdansk, Faculty of Chemistry, Gdansk, Poland; 1711 1345 Department of Medicine and Surgery, University of Perugia, Perugia Italy; 1712 1720 Università degli Studi di Catania, Dipartimento di Chirurgia Generale e Specialità Medico-Chirurgiche, Catania, Italy; 1713 1721 CONICET-Universidad Nacional de Cuyo, Instituto de Histología y Embriología de Mendoza, Mendoza, Argentina; 1714 1722 INSERM U1151, Institut Necker Enfants-Malades (INEM), Team 8, Université Paris Descartes-Sorbonne-Paris Cité, Paris, France; 1715 947 Barcelona Institute of Science and Technology (BIST), Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Barcelona, Spain; Universitat de Barcelona, Facultat de Biologia, Departament de Bioquimica i Biomedicina Molecular, Barcelona, Spain; 1716 1723 Naples University, Department of Veterinary Medicine and Animal Productions, Naples, Italy; 1717 1724 University of Würzburg, Institute of Pathology, Würzburg, Germany; 1718 1725 Kiel University and University Hospital Schleswig-Holstein, Campus Kiel, Institute of Clinical Molecular Biology, Kiel, SH, Germany; 1719 1726 Georgetown University, Department of Biology, Washington, DC, USA; 1720 1727 Columbia University, Department of Pathology and Cell Biology, New York, NY, USA; 1721 1728 University of Illinois, Department of Anesthesiology, Chicago, IL, USA; 1722 1729 Normandy University, UNICAEN, INSERM, UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute Blood and Brain @Caen-Normandie (BB@C), GIP Cyceron, Caen, FRANCE; 1723 1730 University of Sherbrooke, Division of Rheumatology, Department of Medicine, Sherbrooke, QC, Canada; 1724 1731 Section on Eukaryotic DNA Replication, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD,USA; 1725 1732 University of Seville. School of Pharmacy, Instituto de Biomedicina de Sevilla. Sevilla, Spain; 1726 1733 University of Cambridge, Cambridge Institute for Medical Research, UK Dementia Research Institute and Department of Medical Genetics, Cambridge, UK; 1727 1734 Lomonosov Moscow State University, Chemistry Department, Moscow, Russia; 1728 1735 University Medical Center Eppendorf, Institute for Medical Microbiology, Hamburg, Germany; 1729 1736 Charles University, Faculty of Medicine in Hradec Kralove, Department of Medical Biology and Genetics, Hradec Kralove, Czech Republic; 1730 1737 Mannheim University of Applied Sciences, Faculty of Biotechnology, Mannheim, Germany; 1731 1738 Fondazione IRCCS Istituto Neurologico Carlo Besta, Neuromuscular Disease and Immunology Unit, Milan, Italy; University of Brescia, Unit of Biology and Genetics, Department of Molecular and Translation Medicine, Brescia, Italy; 1732 1739 Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia; 1733 1740 University of Ottawa, Department of Cellular and Molecular Medicine, Ottawa, ON, Canada; 1734 1741 National Research Council, Institute of Food Sciences, Avellino, Italy;1742 Stazione Zoologica “Anton Dohrn”, Napoli, Italy; 1735 1741 National Research Council, Institute of Food Sciences, Avellino, Italy; 1736 1743 University of Calabria, Department of Pharmacy, Health and Nutritional Sciences, Cosenza, Italy; 1737 1744 N.N. Blokhin National medical research center of oncology, Department of biomarkers and mechanisms of tumor angiogenesis, Moscow, Russia; 1738 1745 Cancer Research UK Beatson Institute, Glasgow, UK; 1739 1746 University of Seoul, Department of Life Science, Seoul, Korea; 1740 1747 University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 1741 1748 Concordia University, Department of Biology, Montreal, Quebec, Canada; McGill University, Department of Anatomy and Cell Biology, Montreal, Quebec, Canada; 1742 1749 Ernst-Ruska Centre for Microscopy and Spectroscopy with Electrons (ER-C-3/StructuralBiology), Forschungszentrum Jülich, Jülich, Germany; 1743 1750 Saitama University, Graduate School of Science and Engineering, Saitama, Japan; 1744 1751 Rutgers New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Newark, NJ, USA; 1745 1752 Oregon State University, College of Pharmacy, Department of Pharmaceutical Sciences, Portland, OR, USA; 1746 1753 Mashhad University of Medical Sciences, Pharmaceutical Technology Institute, Biotechnology Research Center, Mashhad, Iran; 1747 1754 Boston Children\'s Hospital and Harvard Medical School, Boston, MA, USA; 1748 1755 University of South Carolina, Department of Drug Discovery and Biomedical Sciences, Columbia, SC, USA; 1749 1756 University of Sydney, Northern Clinical School, Kolling Institute of Medical Research, Sydney, NSW, Australia; 1750 1757 Institute for Research in Biomedicine (IRB Barcelona), Cellular Plasticity and Disease Group, Barcelona, Spain; 1751 1758 University of Toyama, Sugitani, Toyama, Japan; 1752 1759 Kyoto University, Graduate School of Agriculture, Division of Applied Life Sciences, Kyoto, Japan; 1753 1760 The University of Tokyo, Graduate School of Medicine, Department of Biochemistry and Molecular Biology, Tokyo, Japan; 1754 1761 University of Helsinki and Helsinki University Hospital, Department of Virology, Helsinki, Finland; 1755 1762 Florida State University, Department of Nutrition, Food and Exercise Sciences, Tallahassee, FL, USA; 1756 1763 Institut Hospital del Mar d\'Investigacions Mèdiques (IMIM), Research Group in Critical Disorders (GREPAC), Barcelona, Spain; 1757 1764 Agricultural Biotechnology Research Institute of Iran (ABRII), Department of Systems Biology, Karaj, Iran; 1758 139 University of Miami, Department of Surgery and Sylvester Comprehensive Cancer Center, Miami, FL, USA; 1759 1765 University of Minho, School of Medicine, Life and Health Sciences Research Institute (ICVS), Braga, Portugal; ICVS/3B\'s - PT Government Associate Laboratory, Braga/Guimarães, Portugal; 1760 1766 CABD/CSIC/Universidad Pablo de Olavide, Departamento de Fisiología, Anatomía y Biología Celular, Sevilla, Spain; 1761 1767 University of Malaga, Department of Molecular Biology and Biochemistry, Malaga, Spain; 1762 1768 Imperial College London, Section of Paediatric Infectious Disease & Virology, London, UK; 1763 1769 INRS-Institut Armand-Frappier, Laval, QC, Canada; 1764 1770 Weill-Cornell, Englander Institute of Precision Medicine, Department of Radiation Oncology, New York, NY, USA; 1765 615 CNC - Center for Neuroscience and Cell Biology, Coimbra, IIIUC - Instituto de Investigação Interdisciplinar, University of Coimbra, Coimbra, Portugal;2315 Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal; 1766 1771 University of Camerino, School of Pharmacy, Experimental Medicine Section, Camerino, Italy; 1767 1772 University of Glasgow, Institute of Molecular, Cell and Systems Biology, Glasgow, Scotland, United Kingdom; 1768 1773 Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain; 1769 1774 Jawaharlal Nehru University, School of Life Sciences, New Delhi, India; 1770 1775 Institute for Stem Cell Science & Regenerative Medicine (inStem), Bangalore, Karnataka, India; 1771 1776 University of Maryland School of Medicine, Department of Anesthesiology, Shock, Trauma and Anesthesiology Research Center, Baltimore, MD, USA; 1772 1777 University of Birmingham, Institute of Biomedical Research, Institute of Cancer and Genomic Sciences, College of Medical and Dental Sciences, Edgbaston, Birmingham, UK; 1773 1778 Health Research Institute Germans Trias i Pujol, Innate Immunity Group, Badalona, Barcelona, Spain; 1774 1779 University of Delhi South Campus, Department of Genetics, New Delhi, India; 1775 1780 Folkhälsan Research Center, Helsinki, Finland; 1776 1781 Mayo Clinic, Department of Molecular Medicine, Rochester, MN, USA; 1777 1782 National Institute of Mental Health and Neurosciences, Department of Neurochemistry, Bengaluru, Karnataka, India; 1778 1783 Duke University, Department of Molecular Genetics and Microbiology, Durham, NC, USA; 1779 1784 Goethe University, Institute of Pharmacology and Toxicology, Frankfurt, Germany; 1780 1785 University of Notre Dame, Department of Biological Sciences, Notre Dame, IN ,USA; 1781 1786 UCL Queen Square Institute of Neurology, Department of Clinical and Movement Neurosciences, London, UK; 1782 1787 University Hospital and University of Zürich, Department of Gastroenterology and Hepatology, Zürich, Switzerland; 1783 1788 University of Calgary, Department of Comparative Biology & Experimental Medicine, Calgary, AB, Canada; 1784 1789 Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity (IHII), University of Texas Medical Branch at Galveston, Galveston, TX, USA; 1785 1790 Amsterdam University Medical Centers location VUmc, Department of Clinical Genetics, Amsterdam, The Netherlands; 1786 1791 University of Kaiserslautern, Phytopathology, Kaiserslautern, Germany; 1787 1792 IRCCS San Raffaele Scientific Institute, Division of Genetics and Cell Biology, Milan, Italy; 1788 1793 Centro di Riferimento Oncologico, CRO-IRCCS, Molecular Oncology Unit, Aviano, Italy; 1789 1794 Medical University of Graz, Gottfried Schatz research center, Graz, Austria; 1790 1795 University Grenoble Alpes and Inserm U1055, Laboratory of Fundamental and Applied Bioenergetics (LBFA), Grenoble, France; 1791 1796 Medical University of Innsbruck, Institute for Cell Biology, Innsbruck, Austria; 1792 1797 Hannover Medical School, Department of Nephrology and Hypertension, Hannover, Germany; 1793 1798 National Institutes of Health, National Institute of Allergy and Infectious Disease, Vaccine Research Center, Bethesda, MD, USA; 1794 1799 Ruhr-University Bochum, Department of Molecular Immunology, Bochum, Germany; 1795 1800 German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany and Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Bonn, Bonn, Germany; 1796 1801 Reseach Center Borstel, Leibniz Lung Center, Priority Research Area Infections, Junior Research Group Coinfection, Borstel, Germany; 1797 1802 Johannes Kepler University Linz, Institute of Biophysics, Linz, Austria; 1798 1803 Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (Dr. Héctor N. Torres), Laboratorio de Señalización y Mecanismos Adaptativos en Tripanosomátidos, Buenos Aires, Argentina; Universidad de Buenos Aires, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina;1804 Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (Dr. Héctor N. Torres), Laboratorio de señalización y mecanismos adaptativos en Tripanosomátidos, Buenos Aires, Argentina; Universidad de Buenos Aires, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina; 1799 1805 Mayo Clinic, Department of Biochemistry and Molecular Biology, Division of Gastroenterology and Hepatology, Rochester, MN, USA; 1800 1806 Technische Universität Dresden, Institute for Physiological Chemistry, Dresden, Germany; 1801 1807 University of Wuerzburg, Department of Vegetative Physiology, Wuerzburg, Germany; 1802 1808 University of Natural Resources and Life Sciences, Department of Applied Genetics and Cell Biology, Vienna, Austria; 1803 1809 Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, MN, USA; 1804 1810 University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB), Esch-sur-Alzette, Luxembourg; 1805 1811 Forschungszentrum Jülich, Institute of Biological Information Processing, IBI-7 (Structural Biochemistry), Jülich, Germany; 1806 1812 University of Campania (L. Vanvitelli), Dipartimento di Scienze Mediche Traslazionali, Naples, Italy; 1807 1813 Department of Medical and Surgical Sciences and Biotechnologies, Sapienza University of Rome, Italy; IRCCS Neuromed, Pozzilli (IS), Italy; 1808 1814 Rutgers Biomedical and Health Sciences, Rutgers University, Robert Wood Johnson Medical School, Department of Pharmacology, New Brunswick , NJ, USA; 1809 1815 National Research Council, Institute of Molecular Genetics, Pavia, Italy; 1810 1816 Helmholtz Centre for Infection Research, Braunschweig, Germany; 1811 1817 Albert Einstein College of Medicine, Department of Developmental and Molecular Biology, Bronx, NY, USA; Albert Einstein College of Medicine, Institute for Aging Studies, Bronx, NY, USA; 1812 1818 Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain; Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; 1813 1819 Rice University, Department of Bioengineering, Houston, TX, USA; 1814 1820 University of Illinois at Chicago, College of Medicine, Department of Biochemistry and Molecular Genetics, Chicago, IL, USA; 1815 1821 University of Oslo, Centre for Molecular Medicine Norway (NCMM), Oslo, Norway; 1816 1822 Université de Pau et des Pays de l’Adour, E2S UPPA, INRAE, UMR1419 Nutrition Métabolisme et Aquaculture, F-64310 Saint-Pée-sur-Nivelle, France; 1817 1823 Cedars-Sinai Medical Center, Department of Medicine, Division of Digestive and Liver Diseases, Los Angeles, CA, USA; 1818 1824 Pennsylvania State University, Department of Biochemistry and Molecular Biology, University Park, PA, USA; 1819 1825 Alpert Medical School of Brown University/Rhode Island Hospital, Division of Cardiothoracic Surgery, Providence, RI, USA; 1820 1826 Iowa State University, Animal Science Department, Ames, IA, USA; 1821 1827 Dokuz Eylul University, Izmir International Biomedicine and Genome Institute, Izmir, Turkey; 1822 1828 University of Alberta, Department of Laboratory Medicine and Pathology, Edmonton, AB, Canada; 1823 1829 University of Rochester Medical Center, Microbiology and Immunology, Rochester, NY, USA; 1824 1830 Johns Hopkins University School of Medicine, Department of Cell Biology, Baltimore, MD, USA; 1825 1831 Indian Institute of Science, Department of Microbiology and Cell Biology, Bangalore, KA, India; 1826 1832 Shenzhen University Health Science Center, School of Dentistry, Shenzhen, Guangdong Province, China; 1827 1833 University of Alabama at Birmingham, Department of Pharmacology & Toxicology, Birmingham, AL, USA; 1828 1834 University of Washington, Department of Medicine, Seattle, WA, USA; VA Puget Sound Health Care System, Seattle, WA, USA; 1829 1835 Soochow University, Institutes for Translational Medicine, Suzhou, Jiangsu, China; 1830 1836 Freie Universitaet Berlin, Department of Veterinary Medicine, Institute of Veterinary Biochemistry, Berlin, Germany; 1831 1837 Johns Hopkins University, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; 1832 1838 University of Pennsylvania, Abramson Cancer Center, Department of Medicine, PA, USA; 1833 1839 Division of Stem Cell and Gene Therapy Research, Institute of Nuclear Medicine & Allied Sciences (INMAS), Defence Research and Development Organization (DRDO), Timar Pur, New Delhi, India; 1834 1840 Thomas Jefferson University, Center for Translational Medicine, Philadelphia, PA, USA; 1835 1841 Women and Infants Hospital of Rhode Island-Warren Alpert Medical School of Brown University, Department of Pediatrics, Providence, RI, USA; 1836 1842 University of Macau, Faculty of Health Sciences, Macau, China; 1837 1843 The University of Hong Kong, School of Chinese Medicine, Hong Kong, China; 1838 1844 Nanjing Agricultural University, College of Animal Science and Technology, Nanjing, Jiangsu, China; 1839 1845 Shanghai Jiao Tong University School of Medicine, Department of Hypertension, Ruijin Hospital, Shanghai, China; 1840 1846 Total Toxicology Labs, Southfield, MI, USA; 1841 1847 Soochow University, College of Pharmaceutical Sciences, Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Suzhou, China; 1842 1848 Fralin Biomedical Research Institute at VTC, Roanoke, VA, USA; 1843 1849 Indiana University School of Medicine, Department of Pediatrics, Indianapolis, IN, USA; 1844 1850 Van Andel Institute, Center for Epigenetics, Grand Rapids, MI, USA; 1845 1851 Fudan University, Zhongshan Hospital, Liver Cancer Institute, Department of Liver Surgery & Transplantation, Shanghai, China; 1846 1852 Juntendo University Graduate School of Medicine, Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Bunkyo-ku, Tokyo, Japan; 1847 1853 National Chung-Hsing University, Institute of Biomedical Sciences, Taichung City, Taiwan; 1848 1854 Jikei University School of Medicine, Research Center for Medical Sciences, Division of Gene Therapy, Tokyo, Japan; 1849 1855 Tokyo Medical and Dental University, Department of Pathological Cell Biology, Tokyo, Japan; 1850 1856 Tohoku University, Graduate School of Agricultural Science, Sendai, Japan; 1851 1857 Geisel School of Medicine at Dartmouth, Department of Biochemistry and Cell Biology, Hanover, NH, USA; 1852 1858 Kobe University Graduate School of Medicine, Center for Infectious Diseases, Division of Infectious Disease Control, Kobe, Japan; 1853 1859 MACS - Agharkar Research Institute, Developmental Biology Group, Pune, India; Savitribai Phule Pune University, Ganeshkhind, Pune, Maharashtra, India; 1854 1860 Mayo Clinic College of Medicine, Department of Experimental Pathology, Rochester, MN, USA; 1855 1861 National Sun Yat-sen University, Institute of Biopharmaceutical Sciences, Kaohsiung, Taiwan; 1856 1863 Huazhong University of Science and Technology, College of Life Science and Technology, Key Laboratory of Molecular Biophysics of Ministry of Education,Wuhan, Hubei, China; 1857 1864 University of Calgary, Cumming School of Medicine, Departments of Medical Genetics and Biochemistry & Molecular Biology, Calgary, Alberta, Canada; 1858 486 Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative diseases (CIBERNED), E-08003 Barcelona, Spain; 1859 1641 Achucarro Basque Center for Neuroscience, Department of Neurosciences, University of the Basque Country EHU/UPV, Leioa, Bizkaia, Spain; 1860 1865 Universidad de la República, Facultad de Agronomía, Departamento de Biología Vegetal, Montevideo, Uruguay; 1861 1866 National Institutes of Health, NIEHS, RTP, Durham, NC, USA; 1862 1867 David Geffen School of Medicine at University of California, Los Angeles, Department of Medicine, Division of Dermatology, Los Angeles, CA, USA; 1863 1868 University of Bern, Institute of Pharmacology, Bern, Switzerland; Sechenov University, Department of Clinical Immunology and Allergology, Moscow, Russia; 1864 1869 INSERM UMR1163, Laboratory of Epithelial Biology and Disease, Imagine Institute, Paris Descartes University, Sorbonne Paris Cité, Hôpital Necker-Enfants Malades, Paris, France; 1865 1870 Boston University School of Medicine, Division of Hematology & Medical Oncology, Department of Pharmacology & Experimental Therapeutics, Boston, MA, USA; 1866 1871 Wayne State University School of Medicine, Department of Ophthalmology, Visual and Anatomical Sciences, Detroit, MI, USA; 1867 1872 University of Pittsburgh, Department of Pharmacology & Chemical Biology, Pittsburgh, PA, USA; 1868 1873 Post Graduate Institute of Medical Education and Research (PGIMER), Department of Urology, Chandigarh, India; 1869 1874 Biomedical Research Institute of New Mexico, VA Healthcare System, Albuquerque, NM, USA; 1870 1875 CSIR-National Physical Laboratory, Dr. K. S. Krishnan Marg, New Delhi, India; 1871 1876 University of Pittsburgh School of Medicine, Departments of Ophthalmology, Cell Biology, and Developmental Biology, Pittsburgh, PA, USA; 1872 1877 Sanjay Gandhi Postgraduate Institute of Medical Sciences, Department of Endocrinology, Lucknow, India; 1873 1878 North Dakota State University, Department of Chemistry and Biochemistry, Fargo, ND, USA; 1874 1879 National Jewish Health, Department of Medicine, Division of Allergy & Immunology, and Division of Pulmonary and Critical Care Medicine, Denver, CO, USA; 1875 1880 Masaryk University, Faculty of Medicine, Department of Biology, Brno, Czech Republic; 1876 1881 Washington State University, Institute of Biological Chemistry, Pullman, WA, USA; 1877 1882 Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK; 1878 1883 Dong-A University, College of Medicine, Department of Molecular Neuroscience, Peripheral Neuropathy Research Center, Busan, Korea; 1879 1885 Lomonosov Moscow State University, Department of Biology, Moscow, Russia; 1880 1886 Indian Institute of Technology Indore, Discipline of Biosciences and Biomedical Engineering, Indore, Madhya Pradesh, India; 1881 1887 Shandong University, School of public health, Department of Toxicology and nutrition. Jinan, Shandong, China; 1882 1888 Korea University, Department of Life Sciences, Seoul, Korea; 1883 1889 Guangzhou University of Chinese Medicine, Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou, China; Hong Kong Baptist University, School of Chinese Medicine, Mr. and Mrs. Ko Chi Ming Centre for Parkinson\'s Disease Research, Hong Kong SAR, China; 1884 1890 University of Colorado Anschutz Medical Campus, Division of Cardiology, Aurora, CO, USA; 1885 1891 Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei, China; 1886 1892 Massachusetts General Hospital and Harvard Medical School, Department of Medicine, Endocrine Division, Boston, MA, USA; 1887 1894 University of Guelph, Department of Food Science, Guelph, Canada; 1888 1671 University of California, San Diego, La Jolla, CA, USA; Rady Children’s Hospital San Diego, San Diego, CA, USA; 1889 1895 Department of Clinical Psychopharmacology and Neurotoxicology, National Institute of Mental Health and Neurosciences, Bengaluru-560029, Karnataka, India; 1890 1896 University of Kentucky, Department of Toxicology and Cancer Biology, Lexington, KY, USA; 1891 1897 Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Santa Lucia, Laboratory of Cell Signaling, Rome, Italy; 1892 1898 University of Western Ontario, Department of Physiology and Pharmacology, London, Ontario, Canada; 1893 1899 University of Oslo, Department of Neuro-/Pathology, Oslo, Norway; 1894 961 Cancer Drug Resistance and Stem Cell Program, University of Sydney, NSW, Australia;1899 University of Oslo, Department of Neuro-/Pathology, Oslo, Norway;1900 University of Bonn, Department of Pharmaceutical & Cellbiological Chemistry, Bonn, Germany; 1895 1901 Biomedical Research Foundation of the Academy of Athens, Laboratory of Neurodegenerative Diseases, Athens, Greece; National and Kapodistrian University of Athens Medical School, First Department of Neurology, Athens, Greece; 1896 1902 University of California, Irvine, Department of Psychiatry and Human Behavior, Irvine, CA, USA; 1897 1903 Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Immune Modulation, University Hospital Erlangen, Erlangen, Germany; 1898 1904 Oslo University Hospital, Institute for Cancer Research, Department of Molecular Cell Biology, Montebello, Oslo, Norway; 1899 1905 Technische Universität Dresden, Center for Regenerative Therapies Dresden, Dresden, Germany; 1900 1906 Jožef Stefan Institute, Department of Biochemistry and Molecular and Structural Biology, Ljubljana, Slovenia; 1901 1907 University Medical Center Hamburg-Eppendorf, Children\'s Hospital, University Children\'s Research@Kinder-UKE, Hamburg, Germany; 1902 1908 Heinrich-Heine-University, Medical Faculty, Institute of Molecular Medicine I, Düsseldorf, Germany; 1903 1909 IRCCS Fondazione Santa Lucia, Rome, Italy; 1904 1910 The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, USA; 1905 548 University of California San Diego, UCSD Moores Cancer Center, La Jolla, CA, USA; 1906 1911 Peking Union Medical College and Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Department of Critical Care Medicine, Beijing, China; 1907 1912 Instituto Oswaldo Cruz, LITEB/IOC, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil; 1908 1913 Case Western Reserve University School of Medicine, Departments of Medicine and Pathology, Cleveland, OH USA; 1909 1914 Rutgers University, New Jersey Medical School and Public Health Research Institute, Newark, NJ, USA; 1910 1915 University of Madras, Department of Biochemistry, Guindy Campus, Chennai, India; 1911 1916 Kolling Institute, Department of Neurogenetics, University of Sydney and Royal North Shore Hospital, St Leonards NSW, Australia; 1912 1917 Hangzhou Normal University, Affiliated Hospital of Hangzhou Normal University, College of Medicine, Holistic Integrative Pharmacy Institutes and Comprehensive Cancer Diagnosis and Treatment Center, Hangzhou, Zhejiang, China; 1913 1918 Iowa State University, Department of Kinesiology, Ames, IA, USA; 1914 1919 University of Nebraska Lincoln, Department of Agronomy and Horticulture, Center for Plant Science Innovation, Lincoln, NE, USA; 1915 1920 University of Illinois at Chicago, Department of Medicine, Chicago, IL, USA; 1916 1921 Shanghai Jiao Tong University, School of Medicine, Ren Ji Hospital, Center for Reproductive Medicine, Shanghai, China; 1917 1922 Wuhan University, College of Life Sciences, Wuhan, Hubei, China; 1918 1923 Zhejiang University, School of Medicine, Department of Biochemistry, Hangzhou, Zhejiang, China; 1919 1924 Cancer Institute of the Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; 1920 1925 University of Tennessee Health Science Center, Department of Physiology, Memphis, TN, USA; 1921 1926 Experimental Physiopathology, Department of Sciences/Experimental Physiopatholgy, Medical School, University of São Paulo, Brazil; 1922 1927 Swedish University of Agricultural Sciences, The Linnean Centre of Plant Biology in Uppsala, Department of Plant Biology, Uppsala, Sweden; 1923 1928 University of Pennsylvania, Perelman School of Medicine, Department of Medicine, Philadelphia, PA, USA; 1924 1929 University of Missouri, Division of Animal Science and Department of Obstetrics, Gynecology & Women\'s Health, Columbia, MO, USA; 1925 1930 Tokai University School of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Isehara, Kanagawa, Japan; 1926 1931 York University, Department of Biology, Toronto, Canada; 1927 1932 University of Utah, Department of Nutrition and Integrative Physiology; Division of Endocrinology, Metabolism, and Diabetes; Investigator, Molecular Medicine Program, Salt Lake City, UT, USA; 1928 1933 Hong Kong Baptist University, Faculty of Science, Department of Biology, Hong Kong, China; Hong Kong Baptist University, Golden Meditech Centre for NeuroRegeneration Sciences, Hong Kong, China; 1929 1934 Ohio Musculoskeletal and Neurological Institute (OMNI) and Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA; 1930 651 Istituto Superiore di Sanità, Department of Oncology and Molecular Medicine, Rome, Italy;1936 Istituto Superiore di Sanità, Department of Oncology and Molecular Medicine, Rome, Italy; Fondazione Umberto Veronesi, Milan, Italy; 1931 1937 Charité University Medicine Berlin, Department of Hepatology & Gastroenterology, Berlin, Germany; 1932 1938 The University of Texas Health Science Center at Houston, McGovern Medical School, Department of Internal Medicine, Cardiology, Houston, TX, USA; 1933 1940 Chengdu Medical College, Department of Anatomy and Histology and Embryology, Development and Regeneration Key Lab of Sichuan Province, Chengdu, China; 1934 1941 University of Glasgow, Institute of Cancer Sciences, Glasgow, UK; 1935 1942 Penn State University College of Medicine, Department of Pediatrics, Hershey, PA, USA; 1936 1943 VIT University, School of Biosciences and Technology, Vellore, Tamilnadu, India; 1937 1944 The Chinese University of Hong Kong, School of Biomedical Sciences, Hong Kong, China; The Chinese University of Hong Kong, Department of Obstetrics and Gynecology, Hong Kong, China; 1938 1945 Inserm Unit 1195 - University of Paris Saclay, Le Kremlin-Bicetre, France; 1939 1946 Tokyo Medical and Dental University (TMDU), Institute of Biomaterials and Bioengineering, Tokyo, Japan; 1940 1947 National Neuroscience Institute, Duke NUS Medical School, Singapore; 1941 1948 Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China;1949 The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Wuhan University, School and Hospital of Stomatology, Department of Oral Medicine, Wuhan, Hubei, China; 1942 1950 Kyoto Prefectural University of Medicine, Department of Anatomy and Neurobiology, Kyoto, Japan; 1943 1951 RIKEN Center for Brain Science, Laboratory for Protein Conformation Diseases, Wako, Saitama, Japan; 1944 1952 Hubei University of Technology, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Wuhan, China; 1945 1953 State Key Laboratory of Membrane Biology, Institute of Zoology, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing, China; 1946 1954 Juntendo University Graduate School of Medicine, Department of Cellular and Molecular Neuropathology, Tokyo, Japan; 1947 1955 Harvard Medical School, Massachusetts General Hospital, Cutaneous Biology Research Center, Charlestown, MA, USA; 1948 1956 University Medicine Goettingen, Neurology, Department of Translational Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration (BIN), Goettingen, Germany; 1949 1957 Foundation for Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology, Heraklion, Crete, Greece; University of Crete, Medical School, Heraklion, Crete, Greece; 1950 173 Tufts University, USDA Human Nutrition Research Center on Aging, Laboratory for Nutrition and Vision Research, Boston, MA, USA; 1951 1958 Duke University, Department of Medicine; Duke University, Department of Molecular Genetics and Microbiology; Duke University, Department of Immunology, Durham, NC, USA; Geriatric Research, Education, and Clinical Center, VA Health Care Center, Durham, NC, USA; 1952 1959 University of North Carolina, Department of Pathology, Chapel Hill, NC, USA; 1953 1960 Nasonova Research Institute of Rheumatology, Moscow, Russia; 1954 1961 Cardiff University, Division of Cancer and Genetics, Heath Park Way, Cardiff, UK; 1955 1962 Goethe-University, Faculty of Medicine, Department of Clinical Pharmacology, Frankfurt, Germany; 1956 1963 INSERM U955, Team “Virus Hepatology Cancers”, Créteil, France; Université Paris-Est, UMR S955, UPEC, Créteil, France; 1957 1964 Chulalongkorn University, Faculty of Allied Health Sciences, Age-Related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Bangkok, Thailand; 1958 1965 University of Liverpool, Department of Cellular and Molecular Physiology, Liverpool, UK; 1959 1966 Centro de Investigaciones Biológicas Margarita Salas, CIB-CSIC, Madrid, Spain; 1960 863 University of Innsbruck, Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, Innsbruck, Austria; University Medical Center Groningen, University of Groningen, Section Systems Medicine of Metabolism and Signaling, Laboratory of Pediatrics, Groningen, The Netherlands;1967 Carl von Ossietzky University Oldenburg, School of Medicine and Health Sciences, Department for Neuroscience, Oldenburg, Germany; 1961 1968 University of Genova, Department of Internal Medicine, Genova, Italy; 1962 136 Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany;1358 Washington University in St. Louis, Department of Biology, St. Louis, MO, USA; 1963 1969 University of Kansas Medical Center, Department of Otolaryngology, Kansas City, KS, USA; 1964 1970 University of Nebraska Medical Center, Departments of Internal Medicine and Biochemistry and Molecular Biology, Omaha, NE, USA; 1965 1971 University of Colorado School of Medicine, Department of Pharmacology, Aurora, CO, USA; 1966 1972 CSIR-Institute of Genomics and Integrative Biology, South Campus, New Delhi, India; 1967 1973 Hannover Medical School, Institute for Molecular and Therapeutic Strategies (IMTTS), Hannover, Germany; 1968 1974 University Medical Center Göttingen, Institute of Cellular Biochemistry, Göttingen, Germany; 1969 1975 South China Agricultural University, Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding/Guangdong Provincial Sericulture and Mulberry Engineering Research Center, College of Animal Science, Guangzhou, China; 1970 1976 University Hospital of Bonn, Institute of Reconstructive Neurobiology, Bonn, Germany; 1971 1977 University of Antwerp, Department of Biomedical Sciences, Peripheral Neuropathy Research Group, Antwerp, Belgium; 1972 1978 Concordia University, Department of Biology, Montreal, Quebec, Canada; 1973 1979 Wayne State University School of Medicine, Department of Pharmacology, Detroit, MI, USA; 1974 688 Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy;759 Sapienza University of Rome, Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Rome, Italy; 1975 1980 University of Oviedo, Department of Functional Biology, Physiology, Oviedo, Asturias, Spain; 1976 1982 Zhejiang University, Life Sciences Institute and Innovation Center for Cell Signaling Network, Hangzhou, China; 1977 1983 Northwestern University, Feinberg School of Medicine, Department of Pathology, Chicago, IL, USA; 1978 47 The Francis Crick Institute, Molecular Cell Biology of Autophagy, London, UK; 1979 1984 Centre de Recherche des Cordeliers, INSERM, Université de Paris, Sorbonne Université, Paris, France; 1980 1985 Nagoya University Graduate School of Medicine, Department of Pathology and Biological Responses, Nagoya, Japan; 1981 1986 University of Belgrade, Faculty of Medicine, Institute of Microbiology and Immunology, Belgrade, Serbia; 1982 1987 University (Federico II) of Naples, Department of Molecular Medicine and Medical Biotechnology, Naples, Italy; 1983 1988 Universidade Federal do Rio de Janeiro, Institute of Biophysics Carlos Chagas Filho, Immunobiology Program, Rio de Janeiro, RJ, Brazil; 1984 1989 National and Kapodistrian University of Athens, Faculty of Biology, Department of Cell Biology and Biophysics, Panepistimiopolis, Athens, Greece; 1985 1990 Medical University of South Carolina, Department of Medicine, Division of Rheumatology & Immunology, Charleston, SC, USA; 1986 1991 University of Bern, Institute of Pathology, Division of Experimental Pathology, Bern, Switzerland; 1987 1992 University of Hong Kong, Cardiology Division, Department of Medicine, Hong Kong, China; 1988 1994 University of Southampton , Biological Sciences, Faculty of Environmental and Life Sciences, Highfield, Southampton, UK; 1989 1995 Universite de Moncton, Department of Chemistry and Biochemistry, Moncton, NB, Canada; 1990 1996 University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, UK; 1991 1997 Weill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, NY, USA; 1992 1998 Komarov Botanical Institute RAS, Laboratory of Molecular and Ecological Physiology, Saint Petersburg, Russian Federation; 1993 1999 Nottingham Trent University, School of Science and Technology, Nottingham, UK; 1994 2000 University of Oxford, John Radcliffe Hospital, Translational Gastroenterology Unit and Department of Paediatrics, Oxford, and Oxford NIHR Biomedical Research Centre, Oxford, UK; 1995 2001 Institute of Psychiatry and Neurology, First Department of Neurology, Warsaw, Poland; 1996 2002 Sechenov First Moscow State Medical University, Institute for Regenerative Medicine, Moscow, Russia; 1997 2003 Mie University, Graduate School of Bioresources, Tsu, Japan; 1998 2004 University of Osnabrück, Department of Biology/Chemistry, and Center of Cellular Nanoanalytics Osnabrück (CellNanOs), Osnabrück, Germany; 1999 2005 Nagoya City University Graduate School of Medical Sciences, Department of Nephro-urology, Nagoya, Aichi, Japan; 2000 2006 University of Tübingen, Center for Plant Molecular Biology (ZMBP), Tübingen, Germany; 2001 516 University of South Florida, Morsani College of Medicine, Department of Molecular Medicine and USF Health Byrd Alzheimer\'s Research Institute, Tampa, FL, USA; Institute for Biological Instrumentation of Russian Academy of Sciences, Laboratory of New Methods in Biology, Pushchino, Moscow region, Russia; 2002 2007 University of Milan, Department of Biosciences, Milan, Italy; 2003 2008 University of Buenos Aires, Institute of Biochemistry and Molecular Medicine, Pathophysiology Department, School of Pharmacy and Biochemistry, CONICET, Buenos Aires, Argentina; 2004 2009 University of Oxford, Nuffield Department of Clinical Neurosciences, Oxford, UK; 2005 2010 Karolinska Institute, Department of Physiology and Pharmacology, Stockholm, Sweden; 2006 2011 University of Murcia, Department of Biochemistry, Molecular Biology B and Immunology; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Unit of Autophagy, Immunity and Cancer, Murcia, Spain; 2007 2012 Fundación Instituto Leloir and IIBBA, CONICET, Buenos Aires, Argentina; Laboratorio de Glicobiología Celular y Genética Aplicada de Levaduras, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina; 2008 2013 Instituto de Investigaciones Biomedicas Alberto Sols (CSIC-UAM), Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III, Madrid, Spain; 2009 2014 Zhejiang University, School of Medicine, Department of Microbiology and Parasitology, Hangzhou, China; 2010 2015 Vanderbilt University School of Medicine, Department of Pathology, Microbiology and Immunology, Nashville, TN, USA; 2011 2016 Center of Translational Immunlogy, University Medical Center Utrecht, Utrecht, The Netherlands; 2012 2017 Goethe University, Institute for Experimental Cancer Research in Pediatrics, Frankfurt am Main, Germany; 2013 2018 University Hospitals Leuven, Department of Neurology, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven, Belgium; 2014 2019 Laboratory of Immunosenescence and Stem Cell Metabolism, Department of Oncology, Ludwig Cancer Institute, University of Lausanne, 1066 Epalinges, Switzerland; 2015 2020 Scientific Institute, IRCCS E. Medea, Laboratory of Molecular Biology, Bosisio Parini, Lecco, Italy; 2016 2021 Instituto de Investigaciones Biomedicas “Alberto Sols” (CSIC-UAM) and CIBERER (CIBER, ISCiii), Madrid, Spain; 2017 2022 Harvard Medical School, Ophthalmology, Boston, MA, USA; 2018 2023 Universitätsklinikum Essen, Institute for Cell Biology (Cancer Research), Essen, Germany; 2019 2024 University of Groningen, University Medical Center Groningen, Department of Hematology, Groningen, The Netherlands; 2020 2025 Tuscia University, Department of Ecological and Biological Sciences (DEB), Viterbo, Italy; 2021 2026 EA 3842, Limoges University, Faculty of Medicine, Limoges cedex, France; 2022 2027 Biomedical Research Foundation, Academy of Athens, Center of Clinical, Experimental Surgery and Translational Research, Athens, Greece; 2023 2028 Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, Université Paul Sabatier, Toulouse, France; 2024 2029 University of Pittsburgh, Department of Pathology, Pittsburgh, PA, USA; 2025 2030 Washington University in St. Louis, Department of Medicine, St. Louis, MO, USA; 2026 2031 Service of Endocrinology, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO)-Department of Physiology, University of Valencia, Valencia, Spain; 2027 2032 University of Montpellier, UMR 5235, Montpellier, France; 2028 2033 Universidade NOVA de Lisboa, CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Lisboa, Portugal; 2029 1362 European Institute of Oncology (IEO) IRCCS, Department of Experimental Oncology, Milan, Italy; University of Milano, Department of Oncology and Hemato-Oncology, Milan, Italy;1467 European Institute of Oncology (IEO) IRCCS, Department of Experimental Oncology, Milan, Italy; 2030 2034 University of Helsinki, Institute of Biotechnology, Electron Microscopy Unit, Helsinki, Finland; 2031 2035 Vall d\'Hebron Research Institute (VHIR)-Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)-Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain; 2032 2036 Institute of Biomedicine of Valencia, Spanish Research Council (CSIC), Valencia, Spain; 2033 2037 University Hospital La Paz Research Institute (IdiPAZ), Cancer and Human Molecular Genetics Area Oto-Neurosurgery Research Group, Madrid, Spain; 2034 2039 University of Toulouse, Institute of Metabolic and cardiovascular Diseases, INSERM UMR 1048, Toulouse, France; 2035 2040 Università Cattolica del Sacro Cuore, Department of Life Science and Public Health Section of Histology and Embryology, Rome, Italy; 2036 2041 Italian Institute for Genomic Medicine (IIGM), Candiolo (TO), Italy; Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO), Italy; 2037 2042 Simon Fraser University, Department of Chemistry, Department of Molecular Biology and Biochemistry, Burnaby, British Columbia, Canada; 2038 2043 Institute for Systems Analysis and Computer Science “A. Ruberti”, National Research Council (IASI–CNR), IRCCS Fondazione Santa Lucia, Rome, Italy; 2039 2044 Eurac Research, Institute for Biomedicine, Bolzano, Italy; 2040 2045 Rheinische Friedrich-Wilhelms-Universität, Institut für Biochemie und Molekularbiologie (IBMB), Bonn, Germany; 2041 2047 University of Oxford, Oxford Parkinson\'s Disease Centre, Department of Physiology, Anatomy and Genetics, Oxford, UK; 2042 2048 Fukushima Medical University, School of Medicine, Department of Anatomy and Histology, Fukushima, Japan; 2043 2049 University of California, Los Angeles, Department of Integrative Biology and Physiology, Los Angeles, CA, USA; 2044 2050 The University of Queensland, School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, St. Lucia, Brisbane, Queensland, Australia; 2045 2051 Babraham Institute, Cambridge, UK; 2046 2052 University of Bonn, Department of Neurology, Molecular Cell Biology Unit, Bonn, Germany; 2047 2053 Universidad Autónoma de Madrid, Centro de Biología Molecular (Severo Ochoa) (CSIC-UAM & CIBERNED), Madrid, Spain; 2048 2054 St Jude Children\'s Research Hospital, Department of Pathology, Memphis, TN, USA; 2049 2055 Chang Gung University College of Medicine and Chang Gung Memorial Hospital, Department of Cardiology, Taoyuan City, Taiwan; National Health Research Institutes, Institute of Cellular and System Medicine, Zhunan, Taiwan; 2050 2056 China Pharmaceutical University, School of Life Science and Technology, Nanjing, Jiangsu, China; 2051 2057 University of California Los Angeles, School of Dentistry, Division of Oral Biology and Medicine, Los Angeles, CA, USA; 2052 2058 Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China; 2053 2059 University of Michigan, Department of Internal Medicine, Division of Hematology and Oncology, Ann Arbor, MI, USA; 2054 2060 Shanghai Ninth People\'s Hospital, National Clinical Research Center for Oral Disease, Shanghai Jiao Tong Univeristy, School of Medicine, Shanghai, China; 2055 2061 Texas A&M College of Dentistry, Department of Endodontics, Dallas, TX, USA; 2056 2062 Third Military Medical University of China, Xinqiao Hospital, Institute of Respiratory Diseases, Chongqing, China; 2057 2063 Soochow University, Center for Circadian Clocks; School of Biology & Basic Medical Sciences, Medical College, Suzhou, Jiangsu, China; 2058 2064 CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Zhongguancun, Beijing, China; 2059 2065 China Agricultural University, College of Biological Sciences, State Key Laboratory of Agro-Biotechnology and MOA Key Laboratory of Soil Microbiology, Beijing, China; 2060 2066 Soochow University, Hematology Center of Cyrus Tang Hematology Institute, School of Medicine, Suzhou, China; 2061 2067 China Academy of Chinese Medical Sciences, Artemisinin Research Center and the Institute of Chinese Materia Medica, Beijing, China; 2062 2068 Shanxi Agricultural University, Shanxi Key Laboratory of Ecological Animal Science and Environmental Veterinary Medicine, Taigu, Shanxi, China; 2063 2069 Sichuan University, West China School of Basic Medical Sciences & Forensic Medicine, Chengdu, China; 2064 1293 National University of Singapore, Yong Loo Lin School of Medicine, Department of Physiology, Singapore;1508 Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China; 2065 2070 The Chinese University of Hong Kong, School of Public Health and Primary Care, Hong Kong, China; 2066 2071 Fourth Military Medical University, College of Stomatology, Department of Oral Anatomy and Physiology and TMD, Xi\'an, China; 2067 2072 The First Affiliated Hospital, Jinan University, Guangzhou, China; 2068 2073 Huazhong Agricultural University, College of Horticulture and Forestry Science, Key Laboratory of Horticultural Plant Biology (Ministry of Education), Wuhan, China; 2069 2074 National University of Singapore, Department of Medicine, Cardiovascular Research Institute, Singapore; 2070 2075 Feinstein Institutes for Medical Research, Center for Immunology and Inflammation, Manhasset, NY, USA; 2071 2076 University of Kentucky, Department of Ophthalmology and Visual Sciences, Lexington, KY, USA; 2072 2077 Zhujiang Hospital of Southern Medical University, Department of Neurology, Guangzhou, Guangdong Province, China; 2073 2078 Cleveland Clinic, Department of Cardiovascular Medicine/Heart and Vascular Institute, Cleveland, OH, USA; 2074 2079 Diabetes and Metabolism Research Institute, Department of Molecular & Cellular Endocrinology; City of Hope Medical Center, Beckman Research Institute, Comprehensive Cancer Center, Duarte, CA, USA; 2075 2080 Xuzhou Medical University, Department of Anesthesiology, Xuzhou, Jiangsu, China; 2076 2081 Stanford University School of Medicine, Department of Neurosurgery, Palo Alto, CA, USA; 2077 2082 University of South Dakota, Division of Basic Biomedical Sciences, Vermillion, SD, USA; 2078 796 Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, USA; 2079 1211 Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA;2083 Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI, USA; 2080 2084 Kaohsiung Medical University, School of Dentistry, College of Dental Medicine, Kaohsiung, Taiwan; 2081 2085 University of Southampton, Faculty of Environmental and Life Sciences, Biological Sciences, and the Institute for Life Sciences, Southampton, UK; 2082 2086 German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Max-Planck-Institute for Metabolism Research, Hamburg Outstation, Hamburg, Germany; Shanghai Qiangrui Biotech Co., Ltd., Fengxian District, Shanghai, China; 2083 2087 Nanjing Agricultural University, College of Horticulture, Weigang NO. 1, Nanjing, China; 2084 2088 Saint Louis University, Department of Biology, Saint Louis, MO, USA; 2085 2089 Air Force Medical University, Xijing Hospital and School of Basic Medicine, Department of Pathology, State Key Laboratory of Cancer Biology, Xi\'an, China; 2086 2090 Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian, China; 2087 2091 Wenzhou Medical University, Key Laboratory of Biotechnology and Pharmaceutical Engineering, School of Pharmaceutical Sciences, Wenzhou, China; 2088 2092 Queen Mary University, Blizard Institute, Flow Cytometry Core Facility, London, UK; 2089 2093 Juntendo University Graduate School of Medicine, Department of Metabolism & Endocrinology, Bunkyo-ku, Tokyo, Japan; 2090 2094 Chiba University Graduate School of Medicine, Department of General Medical Science, Chiba, Japan; 2091 2095 University of Cincinnati College of Medicine, Cincinnati Children’s Research Foundation, Division of Pulmonary Biology, Department of Pediatrics, Cincinnati, OH, USA; 2092 2096 Department of Biological Sciences, University of Denver, Denver, CO, USA; 2093 2097 University of Pennsylvania, Department of Anesthesiology, Philadelphia, PA, USA; 2094 2098 Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China; 2095 2099 Washington University School of Medicine, Department of Neurology, St. Louis, MO, USA; 2096 2100 University of Bonn, Pharmaceutical Institute, Section Pharmacology and Toxicology, Bonn, Germany; 2097 2101 University Hospital RWTH Aachen, Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), Aachen, Germany; 2098 2102 Univ of Pittsburgh and Pittsburgh VA HealthSystem, Department of Pathology, Pittsburgh, PA, USA; 2099 2103 Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Stanford, CA, USA; 2100 2104 Georg August University Göttingen, Institute of Microbiology and Genetics, Department of Genetics of Eukaryotic Microorganisms, Göttingen, Germany; 2101 2105 Harvard Medical School and Brigham & Women\'s Hospital, Precision Neurology Program & APDA Center for Advanced Parkinson Research, Boston, MA, USA; 2102 2106 University of Nottingham, School of Life Sciences, Queen\'s Medical Centre, Nottingham, UK; 2103 2107 Scripps Research Institute, La Jolla, CA, USA; 2104 2109 Amsterdam University Medical Centers, Location AMC, Tytgat Institute for Intestinal Research, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands; 2105 2110 Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk, UK; 2106 2111 University of Edinburgh, MRC Institute of Genetics and Molecular Medicine, Scotland, UK; 2107 1811 Forschungszentrum Jülich, Institute of Biological Information Processing, IBI-7 (Structural Biochemistry), Jülich, Germany;2112 Heinrich-Heine-Universität Düsseldorf Institut für Physikalische Biologie, Düsseldorf, Germany; 2108 2113 Queensland University of Technology, Centre for Tropical Crops and Biocommodities, Science and Engineering Faculty, Brisbane, Queensland, Australia; 2109 2114 Royal Holloway University of London, Centre for Biomedical Sciences, Egham, Surrey, UK; 2110 2046 National Institutes of Health, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA; 2111 2115 University of Nebraska-Lincoln, Department of Plant Pathology, Lincoln, NE, USA; 2112 2116 Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Department of Stem Cell Biology, Erlangen, Germany; 2113 2117 University of Toronto, Faculty of Medicine, Department of Immunology, Toronto, ON, Canada; 2114 2118 Department of Obstetrics and Gynecology, Weill Cornell Medicine, 1300 York Avenue, Box 35, New York, NY, United States.; 2115 2119 MFP CNRS UMR 5234, University of Bordeaux, Bordeaux, France; 2116 2120 Institut Pasteur, Membrane Biochemistry and Transport, Paris, France; 2117 2121 National University of Singapore, Yong Loo Lin School of Medicine, Healthy Longevity Translational Research Program, Singapore; National University Health System, Centre for Healthy Longevity, Singapore; 2118 2122 School of Medicine, Shenzhen University, Shenzhen, China; 2119 2123 Kanazawa University, WPI-Nano Life Science Institute (WPI-nanoLSI), Kanazawa, Ishikawa, Japan; 2120 2124 University of Zurich, Institute of Experimental Immunology, Switzerland, Zurich; 2121 2125 Southwest Medical University, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Jiangyang District, Luzhou, China; 2122 2126 University of California San Diego, Department of Neurosciences, La Jolla, CA, USA; 2123 2127 University of Maryland School of Medicine, Center for Shock, Trauma and Anesthesiology Research (STAR), Departments of Anesthesiology, Anatomy & Neurobiology, Baltimore, MD, USA; 2124 2128 NHRI, Institute of Cellular and System Medicine, Zhunan, Taiwan; 2125 2129 University of North Dakota, Biology School of Medicine and Health Sciences, Department of Biomedical Sciences, Grand Forks, ND, USA; 2126 2130 Soochow University, Department of Pathogenic Biology, Suzhou, Jiangsu Province, China; 2127 2131 First Affiliated Hospital of Xi\'an Jiaotong University School of Medicine, Center for Translational Medicine, Xi\'an, Shaanxi, China; 2128 2132 Zhejiang Provincial People\'s Hospital, Department of Endocrinology, Hangzhou, China; 2129 2133 University of Kansas, Department of Molecular Biosciences, and University of Kansas Medical School, University of Kansas Cancer Center, Department of Radiation Oncology, Lawrence, KS, USA; 2130 2134 Zhejiang University School of Medicine, Department of Toxicology of School of Public Health, and Department of Gynecologic Oncology of Women\'s Hospital, Hangzhou,China; 2131 2135 The Broad Institute of Harvard and MIT, Massachusetts General Hospital, Harvard Medical School, Department of Molecular Biology, Cambridge, MA, USA; 2132 2136 Zhejiang University, Department of Biochemistry in School of Medicine, Hangzhou, Zhejiang Province, China; 2133 2137 Shenzhen University, College of Medicine, Shenzhen, Guangdong, China; 2134 2138 The University of Hong Kong, Department of Anesthesiology, Queen Mary Hospital, Hong Kong, China; 2135 2139 Wuhan University, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan, China; 2136 2140 Shanghai Jiao Tong University School of Medicine, Ruijin Hospital, Department of Otolaryngology & Head and Neck Surgery, Shanghai, China; 2137 2141 Friedrich-Alexander University Erlangen-Nürnberg, University Hospital Erlangen, Department of Molecular Neurology, Erlangen Germany; 2138 2142 Research Department, National Neuroscience Institute, Singapore; 2139 2143 Southern University of Science and Technology, Department of Biology, Shenzhen, China; 2140 2144 Sichuan University, West China Hospital, Centre of Geriatrics and Gerontology, Chengdu, China; 2141 2145 University of Electronic Science and Technology of China, School of Medicine, Chengdu, China; Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Department of Pharmacy, Chengdu, Sichuan, China; 2142 2146 Wenzhou Medical University, School of Pharmaceutical Sciences, Wenzhou, China; 2143 2147 Queensland University of Technology, Institute of Health and Biomedical Innovation, Kelvin Grove, Brisbane, Queensland, Australia; 2144 2148 Sun Yat-sen University, School of Life Sciences, Guangdong Provincial Key Laboratory of Plant Resources, State Key Laboratory of Biocontrol, Guangzhou, China; 2145 2149 South China Agricultural University, College of Veterinary Medicine, Guangzhou, Guangdong, China; 2146 2150 Southwest Hospital, Third Military Medical University (Army Medical University), Key Laboratory of Hepatobiliary and Pancreatic Surgery, Institute of Hepatobiliary Surgery, Chongqing, China; 2147 2151 University of Alabama at Birmingham, Division of Cardiovascular Disease, Department of Medicine, Birmingham, AL, USA; 2148 2152 Georgia State University, The Center for Molecular and Translation Medicine, Atlanta, GA, USA; 2149 2153 Biomedical Research Foundation of the Academy of Athens (BRFAA), Center of Clinical, Experimental Surgery, & Translational Research, Athens, Greece; 2150 2154 Shanghai Sixth People\'s Hospital, Department of Cardiovascular Medicine, and Shanghai Jiaotong University School of Medicine, Shanghai Institute of Immunology, Shanghai, China; 2151 2155 Institute of Neurosciences and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; 2152 2156 Jinan University, College of Life Science and Technology, Guangzhou, China; 2153 2157 Yangzhou University, College of Veterinary Medicine, Jiangsu Province, China; 2154 2158 Kyoto Institute of Technology, Department of Applied Biology, Matsugasaki, Sakyo-ku, Kyoto, Japan; 2155 2159 Ehime University Graduate School of Medicine, Department of Cardiology, Pulmonology, Hypertension & Nephrology, Shitsukawa, Toon, Ehime, Japan; 2156 2160 Columbia University, Department of Neurology, and Pathology and Cell Biology, New York, NY, USA; 2157 2161 Juntendo University School of Medicine, Department of Gastroenterology, Bunkyo-ku, Tokyo, Japan; 2158 2162 Indiana University School of Medicine, Department of Pathology and Laboratory Medicine, Indianapolis, IN, USA; 2159 2163 National Cheng Kung University, College of Medicine, Department of Physiology, Tainan City, Taiwan; 2160 2164 University of Virginia, Departments of Medicine, Pharmacology, Molecular Physiology & Biological Physics, Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA; 2161 2165 Asahikawa Medical University, Department of Ophthalmology, Hokkaido, Japan; 2162 2166 Hong Kong Baptist University, Mr. and Mrs. Ko Chi Ming Centre for Parkinson\'s Disease Research, School of Chinese Medicine, Hong Kong, China; 2163 2167 Nathan Kline Institute for Psychiatric Research, Center for Dementia Research, Orangeburg, NY; New York University Langone Health, Department of Psychiatry, New York, NY, USA; 2164 2168 University of Wisconsin-Madison, Department of Surgery, Madison, WI, USA; 2165 2169 Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health, CAS Key Laboratory of Tissue Microenvironment & Tumor, Laboratory of Molecular Cardiology, Shanghai, China; 2166 2170 Capital Medical University, School of Basic Medical Sceinces, Department of Neurobiology, Beijing, China; 2167 2171 University of Kentucky, Department of Cancer Biology & Toxicology, Lexington, KY, USA; 2168 2172 University of Alabama at Birmingham, Department of Medicine, Division of Cardiovascular Disease, Birmingham, AL, USA; 2169 2173 University of Iowa Carver College of Medicine, Fraternal Order of Eagles Diabetes Research Center, Department of Anatomy and Cell Biology, Iowa City, IA, USA; 2170 2174 The Fourth Military Medical University, Xijing Hospital, Department of Orthopaedics, Xi\'an, China; 2171 2175 Shandong Cancer Hospital and Institute, Cancer Research Center, Jinan, Shandong Province, China; 2172 2176 Taipei Medical University, College of Medical Science and Technology, Graduate Institute of Cancer Biology and Drug Discovery, Taipei, Taiwan; 2173 2177 The Fourth Military Medical University, Tangdu Hospital, Department of Experimental Surgery, Xi\'an, Shaanxi, China; 2174 2178 Chung Shan Medical University, Institute of Medicine, Taichung, Taiwan; 2175 2179 Jiangsu University, School of Medicine, Zhenjiang, Jiangsu, China; 2176 2180 Yale University School of Medicine, Department of Comparative Medicine and Department of Cellular and Molecular Physiology, New Haven, CT, USA; 2177 2181 Jinan University, Medical College, Key Laboratory for Regenerative Medicine of the Ministry of Education, Division of Histology and Embryology, Guangzhou, China; 2178 2182 Hangzhou Normal University, School of Medicine, College of Pharmacy, Hangzhou, Zhejiang, China; 2179 2183 University of Southeast, School of Medicine, Department of Pharmacology, Nanjing, JiangSu, China; 2180 2184 University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, Parkville, Victoria, Australia; 2181 2185 Chinese University of Hong Kong, School of Biomedical Sciences, Hong Kong, China; 2182 2186 Fourth Medical Center of the Chinese PLA General Hospital, Trauma Research Center, Beijing, China; 2183 2187 Duke-NUS Medical School, Cardiovascular and Metabolic Disorders Program, Singapore, Singapore; 2184 2188 Zhejiang University School of Medicine, Department of Biochemistry, and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Hangzhou, China; 2185 2189 Shandong Agricultural University, College of Plant Protection, Shandong, China; 2186 2190 Zhejiang University, College of Pharmaceutical Sciences, Hangzhou, China; 2187 2191 Soochow University, College of Pharmaceutical Sciences, Department of Pharmacology, Suzhou, Jiangsu, China; 2188 2192 The University of British Columbia, Department of Biochemistry and Molecular Biology, Vancouver, BC, Canada; 2189 2193 Dong-A University College of Medicine, Department of Anatomy and Cell Biology, Busan, Korea; 2190 2194 The Jikei University School of Medicine, Department of Biochemistry, Minato-ku, Tokyo, Japan; 2191 2195 ETH Zürich, Institute of Biochemistry, Zürich, Switzerland; 2192 2196 Tabriz University of Medical Sciences, Molecular Medicine Research Center, Tabriz, Iran; 2193 2197 Hwa Chong Institution, Singapore, Singapore; 2194 2198 Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin, China; 2195 2199 Temple University, Center for Metabolic Disease Research and Department of Physiology, Philadelphia, PA, USA; 2196 2200 The Chinese University of Hong Kong, State Key Laboratory of Digestive Disease, Department of Medicine and Therapeutics, Hong Kong, China; 2197 2201 Tsinghua University, School of Life Sciences, Tsinghua University-Peking University Joint Center for Life Sciences, State Key Laboratory of Membrane Biology, Beijing, China; 2198 2202 Hepatobiliary Section, Department of Internal Medicine, Kaohsiung Medical University Hospital, and Hepatitis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 2199 2203 University of Toronto, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; 2200 2204 Air Force Medical University, Xijing Hospital, Department of Plastic and Reconstructive Surgery, Xi\'an, China; 2201 2205 Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 201203 Shanghai, China; Department of Cell Biology, Harvard Medical School, Boston, MA, USA; 2202 2206 Central South University, The Second Xiang-Ya Hospital, National Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Changsha, Hunan, China; 2203 2207 Kaohsiung Medical University, Graduate Institute of Medicine, Kaohsiung, Taiwan; 2204 2208 First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China; 2205 2209 Beijing Institute of Basic Medical Sciences, Beijing, China; 2206 2210 City University of Hong Kong, Department of Biomedical Sciences, Hong Kong, China; 2207 2211 Icahn School of Medicine at Mount Sinai, Departments of Neurology and Neuroscience, New York, NY, USA; 2208 2212 Graduate School of Dong-A University, College of Medicine, Department of Translational Biomedical Sciences, Busan, Korea; 2209 2214 Centre for Genomic Regulation (CRG), Department of Cell and Developmental Biology, Barcelona, España; 2210 2215 Laboratory of Pain and Signaling, Butantan Institute, Sao Paulo, SP, Brazil; Stanford University, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford, CA, USA; 2211 2216 University of Brescia, Department of Molecular and Translational Medicine, Brescia, Italy; 2212 2217 University of Texas Southwestern Medical Center, Department of Surgery, Dallas, TX, USA; 2213 2218 Cancer Research UK Beatson Institute, Glasgow, UK; University of Glasgow, Institute of Cancer Sciences, Glasgow, UK; 2214 2219 University of California, Davis, Department of Pathology and Laboratory Medicine, Shriners Hospitals for Children, Institute for Pediatric Regenerative Medicine, Sacramento, CA, USA; 2215 2220 Tabriz University of Medical Sciences, Faculty of Advanced Medical Sciences, Department of Medical Nanotechnology, Tabriz, Iran; 2216 2221 University Monastir, Faculty of Medicine, LR12ES05, Lab-NAFS ‘Nutrition - Functional Food & Vascular Health’, Monastir, Tunisia; 2217 2222 University of Virginia, Department of Neuroscience, Charlottesville, VA, USA; 2218 2223 Boston University, Department of Biomedical Engineering, Boston, MA, USA; 2219 2224 University of Arizona, Department of Pharmacology and Toxicology, Tucson, AZ, USA; 2220 2225 Peking University First Hospital, Renal Division, Xi Cheng District, Beijing, China; 2221 2226 Chinese Academy of Sciences, Institute of Biophysics, National Laboratory of Biomacromolecules, Beijing, China; 2222 2227 Zhejiang University School of Medicine, Department of Pathology, Hangzhou, China; 2223 2228 University of Science & Technology of China, School of Life Sciences, Hefei, Anhui, China; 2224 2229 Rutgers Robert Wood Johnson Medical School, Department of Neuroscience and Cell Biology, Piscataway, NJ, USA; 2225 2230 Thomas Jefferson University/Vickie & Jack Farber Institute for Neuroscience, Hospital for Neuroscience, Philadelphia, PA, USA; 2226 2231 Soochow University, Department of Pharmacology and Laboratory of Cerebrovascular Pharmacology, College of Pharmaceutical Science, Suzhou, Jiangsu, China; 2227 2232 People\'s Hospital of Hangzhou Medical College, Zhejiang Provincial People\'s Hospital, Department of Oncology, Hangzhou, China; Zhejiang Provincial People\'s Hospital, Clinical Research Institute, Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Hangzhou, China; 2228 2233 University of Alabama at Birmingham, Department of Pathology, Birmingham, AL, USA; 2229 2234 School of Radiation Medicine and Protection and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China; 2230 2309 The Chinese University of Hong Kong, Department of Medicine and Therapeutics and Department of Anaesthesia and Intensive Care, Hong Kong, China; 2231 2235 Huazhong Agricultural University, School of Veterinary Medicine/ Biomedical Center, Hongshan, Wuhan, China; 2232 2236 Henan University of Technology, College of Bioengineering, Zhengzhou, China; 2233 2237 University of Utah, Huntsman Cancer Institute and Department of Oncological Sciences, Salt Lake City, UT, USA; 2234 2238 The University of Texas Health Science Center at Houston (UTHealth), McGovern Medical School, The Brown Foundation Institute of Molecular Medicine, Department of Neurobiology and Anatomy, Programs in Human and Molecular Genetics and Neuroscience of the MD Anderson UTHealth GSBS, Houston, TX, USA; 2235 2239 Wake Forest Baptist Comprehensive Cancer Center, Department of Cancer Biology, Winston-Salem, NC, USA;2240 Hungarian Academy of Sciences, Budapest, Hungary; Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary; 2236 2241 The Second Affiliated Hospital and Yuying Children\'s Hospital of Wenzhou Medical University, Department of Orthopaedics, Wenzhou, Zhejiang Province, China; 2237 2242 College of Respiratory and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China; 2238 2243 University of Newcastle, School of Biomedical Sciences and Pharmacy, NSW, Australia; 2239 2244 University of Houston, College of Pharmacy, Department of Pharmacological & Pharmaceutical Sciences, Houston, TX, USA; 2240 2245 University of Maryland, Molecular Virology Laboratory, VA-MD College of Veterinary Medicine, College Park, MD, USA; 2241 2246 East China Normal University, Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, Shanghai, China; 2242 2247 Nanjing Agricultural University, College of Plant Protection, Department of Plant Pathology, Nanjing, China; 2243 1430 Department of Physiology, Department of Obstetrics/Gynecology, Wayne State University, Detroit, MI, USA; 2244 2248 Rutgers University, Department of Surgery, New Brunswick, NJ, USA; 2245 2249 Nanjing University of Chinese Medicine, Nanjing, China; 2246 2250 Central China Normal University, College of Life Sciences, Wuhan, Hubei Province, China; 2247 2251 The Fourth Military Medical University, National Key Discipline of Cell Biology, Department of Physiology and Pathophysiology, Xi\'an, Shaanxi, China;2252 The Fourth Military Medical University, Tangdu Hospital, Department of Neurosurgery, Xi\'an, Shaanxi, China; 2248 2253 Beijing Academy of Agriculture and Forestry Sciences, Institute of Plant and Environment Protection, Beijing, China; 2249 2255 Shandong University, School of Life Sciences, Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, Qingdao, China; 2250 2256 Peking University Health Sciences Center, Department of Biochemistry and Molecular Biology, Beijing, China; 2251 2257 Zhejiang University, the First Affiliated Hospital, Hangzhou, Zhejiang, China; 2252 2258 Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China; 2253 2259 University of Sydney, Westmead Institute for Medical Research, Centre for Transplant and Renal Research, Sydney NSW, Australia; 2254 2260 Shenzhen University, Health Science Center, School of Pharmaceutical Sciences, Shenzhen, Guangdong, China; 2255 2261 Wuhan University, Department of Cell Biology, College of Life Sciences, Wuhan, Hubei, China; 2256 2262 University of Calgary, Cumming School of Medicine, Libin Cardiovascular Institute of Alberta, Departments of Biochemistry & Molecular Biology and Physiology & Pharmacology, Calgary, Alberta, Canada; 2257 2263 Children’s Hospital Medical Center, Division of Experimental Hematology and Cancer Biology, Cincinnati, OH, USA; 2258 2264 China Pharmaceutical University, State Key Laboratory of Natural Medicines, Nanjing, Jiangsu, China; 2259 2265 Karolinska Institutet Division of Toxicology, Institute of Environmental Medicine, Stockholm, Sweden; Lomonosov Moscow State University, Faculty of Basic Medicine, Moscow, Russia; 2260 2266 Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, China; 2261 2267 Southwest Medical University, Department of Medical Cellular Biology, Luzhou, Sichuan, China; 2262 2268 Massachusetts General Hospital, Department of Medicine, Diabetes Unit and Center for Genomic Medicine, Boston, MA, USA; Harvard Medical School, Department of Medicine, Boston, MA, USA; 2263 1948 Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei, China; 2264 2269 Chinese People\'s Liberation Army General Hospital, Department of Cardiology, Beijing, China; 2265 2270 Third Military Medical University, College of Pharmacy, Department of Pharmacology, Chongqing, China; 2266 2271 Huazhong Agricultural University, College of Veterinary Medicine, State Key Laboratory of Agricultural Microbiology, Wuhan, China; 2267 2272 Zhejiang University, Department of Horticulture, Hangzhou, China; 2268 2273 Guangxi Medical University, School of Preclinical Medicine, Department of Physiology, Nanning,China; 2269 2274 Zhejiang University, MOA Key Laboratory of Animal Virology, Hangzhou, Zhejiang, China; 2270 2275 The Second Affiliated Hospital and Yuying Children\'s Hospital of Wenzhou Medical University, Department of Orthopaedics, Wenzhou, Zhejiang, China; 2271 2276 Chinese Academy of Sciences, Guangzhou Institutes of Biomedicine and Health, CAS Key Laboratory of Regenerative Biology, Guangzhou, China; 2272 2277 Queensland University of Technology, Institute of Health and Biomedical Innovation, Brisbane, QLD, Australia; 2273 2278 Texas A&M University, Institute of Biosciences and Technology, Houston, TX, USA; 2274 2279 Soochow University, Laboratory Animal Center, Suzhou, Jiangsu Province, China; 2275 2280 Zhejiang University School of Medicine, Department of Environmental Medicine, Hangzhou, Zhejiang Province, China; 2276 2281 University at Buffalo, The State University of New York, Department of Physiology and Biophysics, Buffalo, NY, USA; 2277 2282 Zhengzhou University, Third Affiliated Hospital and Institute of Neuroscience, Henan Key Laboratory of Child Brain Injury, Zhengzhou, China; Gothenburg University, Institute of Neuroscience and Physiology, Gothenburg, Sweden; 2278 2283 Nanjing Medical University, Department of Physiology, Nanjing, Jiangsu, China; 2279 2284 University of Kentucky, College of Medicine, Department of Molecular and Cellular Biochemistry, Lexington, KY, USA; 2280 2285 Shanghai Jiao Tong University, Bio-X Institutes, Shanghai, China; 2281 2286 The Ohio State University, Department of Surgery, Columbus, OH, USA; 2282 2287 Shenzhen University Medical School, Department of Biochemistry and Molecular Biology, Shenzhen, China; 2283 2288 State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin, China; 2284 2289 University California, San Diego, Division of Biological Sciences, Section of Molecular Biology, CA, USA; 2285 2290 University Medical Center of Johannes Gutenberg-University, Institute for Virology, Mainz, Germany; 2286 2291 University of Padova, Biology Department, Padova, Italy; 2287 2292 Rutgers University, Department of Chemical Biology, Ernest Mario School of Pharmacy, Piscataway, NJ, USA; 2288 2293 Moscow State University, A.N.Belozersky Institute of Physico-Chemical Biology, Department of Functional Biochemistry of Biopolymers, Moscow, Russia; 2289 946 Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain; Universitat de Barcelona, Departament de Bioquímica I Biomedicina Molecular, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain; 2290 2294 University of Michigan, Departments of Surgery and Pathology, Ann Arbor, MI, USA; 2291 2295 Institute of Life Sciences, Chongqing Medical University, Chongqing, PR China; 2292 2296 The University of Queensland, Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, Brisbane, Australia; 2293 2297 University of Innsbruck, Division of Cell Metabolism and Differentiation Research, Research Institute for Biomedical Aging Research, Innsbruck, Austria; 2294 2298 Indiana University School of Medicine, Department of Biochemistry and Molecular Biology, Indianapolis, IN, USA; 2295 2299 Swedish University of Agricultural Sciences, Department of Forest Mycology and Plant Pathology, Uppsala, Sweden; 2296 2300 Southern Medical University, Shenzhen Hospital, Department of Pathology, Bao\'an District, Shenzhen, Guangdong, China; 2297 2301 Lovelace Respiratory Research Institute, Molecular Biology and Lung Cancer Program, Albuquerque, NM, USA; 2298 2302 Tokyo Medical and Dental University (TMDU), Medical Hospital, Department of Gastroenterology and Hepatology, Bunkyo-ku, Tokyo, Japan.; 2299 2303 Huazhong University of Science and Technology, School of Basic Medicine, Wuhan, HuBei, China; 2300 2304 Maastricht University Medical Center, School for Cardiovascular disease (CARIM), Department of Pathology, Maastricht, The Netherlands; University of Edinburgh, Centre for Cardiovascular Science, Edinburgh, UK; 2301 2305 Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA; 2302 2306 Hong Kong Baptist University, School of Chinese Medicine, Hong Kong, China;2307 Hong Kong Baptist University, School of Chinese Medicine, Hong Kong, lxChina）

出处： Autophagy 2021 Vol.17 No.1 P1-382

关键词： Autophagosome;cancer;flux;LC3;lysosome;macroautophagy;neurodegeneration;phagophore;stress;vacuole

摘要： In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, a ...

作者： Wei Jin  ^{1   2} , Huijing Yin  ³ , Hao Li  ² , Xian-Jun Yu  ² , Hua-Xiang Xu  ² , Liang Liu  ² （Affiliations 1 Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Pancreatic Surgery, Pancreatic Cancer Institute, Fudan University, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Shanghai, China. 3 Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Journal of cellular and molecular medicine 2021

关键词： EMT;IL-1β;NETs;Pancreatic Cancer.

摘要： Neutrophil extracellular DNA traps (NETs) are newly discovered forms of activated neutrophils. Increasing researches have shown that NETs play importa ...

作者： Tingmang Yan  ¹ , Dapeng Zhou  ¹ , Youwei Shi  ¹ , Di Cui  ¹ , Juntao Jiang  ¹ , Bangmin Han  ¹ , Shujie Xia  ¹ , Zhou Wang  ^{2   3   4   5} , Haitao Liu  ¹ , Wenhuan Guo  ⁶ , Yifeng Jing  ¹ （Affiliations 1 Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. 3 Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. 4 Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. 5 UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. 6 Pathology Center, Shanghai General Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.）

出处： Frontiers in oncology 2021

关键词： E3 ubiquitin ligase;Siah2;androgen deprivation therapy;androgen receptor;castration-resistant prostate cancer.

摘要： Siah2 is an E3 ubiquitin ligase that targets androgen receptor (AR) and plays an important role in the development of castration-resistant prostate ca ...