上海交通大学附属第一人民医院肿瘤科是上海市三甲综合医院中最早设立的肿瘤专科，是医院“十二五”期间重点发展的学科之一。2009年，医院整合肿瘤相关学科资源，成立了肿瘤中心，学科带头人黄倩教授，中心主任王理伟教授，肿瘤中心副主任王红霞（兼肿瘤科副主任[主持，南]）、刘勇副主任医师，北部执行主任李琦主任医... [详细]
作者： Yanli Li, Rui Yang, Limo Chen, Sufang Wu （Affiliations 1 Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, PR China. 2 Department of Thoracic/Head & Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009 USA.）
出处： Future oncology (London, England) 2020 Vol.16 No.34 P2853-2861
关键词： CD38;biomarker;cancer immunotherapy;immune checkpoint therapy;immunomodulation;tumor microenvironment.
摘要： CD38 is a transmembrane glycoprotein that is widely expressed in a variety of human tissues and cells, especially those in the immune system. CD38 pro ...
作者： Jiawen Zhang, Qinyi Zhang, Jing Zhang, Qingying Wang （Affiliations 1 Department of Obstetrics and Gynecology, Shanghai Tenth People\'s Hospital, School of Medicine, Tongji University, Shanghai, China. 2 Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China. 3 Department of Integrated Therapy, Shanghai Cancer Center, Fudan University, Shanghai, China. 4 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.）
出处： DNA and cell biology 2020 Vol.39 No.9 P1545-1557
关键词： ACAP1;cell stemness;immune infiltration;ovarian cancer.
摘要： ADP-ribosylation factor (Arf) GTPase-activating protein (GAP) with coiled-coil, ankyrin repeat and PH domains 1 (ACAP1) is an Arf6 GAP that regulates ...
作者： Chong Li, Lungen Lu, Zhongtian Qi, Yongqiang Zhu, Fengtao Su, Ping Zhao, Hui Dong （Affiliations 1 Cancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. 2 Shanghai Key Laboratory of Pancreatic Diseases, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Department of Microbiology, Second Military Medical University, Shanghai, China. 4 Chinese National Human Genome Center at Shanghai, Shanghai, China.）
出处： Frontiers in microbiology 2020 Vol.11 P535673
关键词： hepatitis C virus;host responses;lipid metabolism;miR-122;miRNome;transcriptome.
摘要： Hepatitis C virus (HCV)-host cell interaction during infection disturbs cellular homeostasis and culminates in pathological consequences. The processe ...
作者： Ye Yuan，Ruonan Bo，Di Jing，Zhao Ma，Zhongling Wang，Tzu-yin Lin，Lijie Dong，Xiangdong Xue，Yuanpei Li （Center for Smart Materials and Devices，State Key Laboratory of Advanced Technology for Materials Synthesis and Processing，Wuhan University of Technology，Wuhan 430070，China；Department of Biochemistry and Molecular Medicine，UC Davis Comprehensive Cancer Center，University of California Davis，Sacramento 95817，USA；Department of Biochemistry and Molecular Medicine，UC Davis Comprehensive Cancer Center，University of California Davis，Sacramento 95817，USA；School of Veterinary Medicine，Yangzhou University，Yangzhou 225009，China；Department of Biochemistry and Molecular Medicine，UC Davis Comprehensive Cancer Center，University of California Davis，Sacramento 95817，USA；Department of Oncology，Xiangya Hospital，Central South University，Changsha 410008，China；Department of Biochemistry and Molecular Medicine，UC Davis Comprehensive Cancer Center，University of California Davis，Sacramento 95817，USA；Department of Biochemistry and Molecular Medicine，UC Davis Comprehensive Cancer Center，University of California Davis，Sacramento 95817，USA；Department of Radiology，Shanghai General Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200080，China；Division of Hematology/Oncology，Department of Internal Medicine，University of California Davis，Sacramento 95817，USA；Center for Smart Materials and Devices，State Key Laboratory of Advanced Technology for Materials Synthesis and Processing，Wuhan University of Technology，Wuhan 430070，China；Department of Biochemistry and Molecular Medicine，UC Davis Comprehensive Cancer Center，University of California Davis，Sacramento 95817，USA；College of Life Sciences，Northwest University，Xi\'an 710069，China）
出处： 纳米研究(英文版) 2020 第13卷 第2期 P503-510
关键词： PORPHYRIN；7-ethyl-10-hydroxy-camptothecin(SN-38)；drug；delivery；self-indication；nanotheranostics；photodynamic；therapy
摘要： Nanotheranostics with comprehensive diagnostic and therapeutic capabilities show exciting cancer treatment potentials.Here,we develop an excipient-fre ...
作者： Rong Jiang, Jianqing Zhu, Jae Weon Kim, Jihong Liu, Kazuyoshi Kato, Hee Seung Kim, Yuqin Zhang, Ping Zhang, Tao Zhu, Daisuke Aoki, Aijun Yu, Xiaojun Chen, Xipeng Wang, Ding Zhu, Wei Zhang, Huixun Jia, Tingyan Shi, Wen Gao, Sheng Yin, Yanling Feng, Libing Xiang, Aikou Okamoto, Rongyu Zang （Affiliations 1 Shanghai Gynecologic Oncology Group and Ovarian Cancer Program, Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China. 2 Shanghai Gynecologic Oncology Group and Department of Gynecologic Oncology, Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, China. 3 Korean Gynecologic Oncology Group and Department of Obstetrics and Gynecology, Seoul National University, Seoul, Korea. 4 Shanghai Gynecologic Oncology Group and Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. 5 Japanese Gynecologic Oncology Group and Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan. 6 Japanese Gynecologic Oncology Group and Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan. 7 Shanghai Gynecologic Oncology Group and Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. 8 Shanghai Gynecologic Oncology Group and Department of Gynecology and Obstetrics, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. 9 Shanghai Gynecologic Oncology Group and Department of Gynecology, Hunan Provincial People\'s Hospital, Changsha, China. 10 Shanghai Gynecologic Oncology Group and Department of Biostatistics, School of Public Health, Fudan University, Shanghai, China. 11 Shanghai Gynecologic Oncology Group and Clinical Statistics Center, Shanghai General Hospital, Shanghai, China. 12 Shanghai Gynecologic Oncology Group and Ovarian Cancer Program, Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China. xianglibing_123@sina.com. 13 Japanese Gynecologic Oncology Group and Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.）
出处： Journal of gynecologic oncology 2020 Vol.31 No.5 Pe86
关键词： Cytoreduction Surgical Procedures;Neoadjuvant Therapy;Ovarian Cancer.
摘要： Background: Two randomized phase III trials (EORTC55971 and CHORUS) showed similar progression-free and overall survival in primary or interval debulk ...
作者： Tong Wang, Bo Jing, Dongliang Xu, Yueling Liao, Hongyong Song, Beibei Sun, Wenzheng Guo, Jianhua Xu, Kaimi Li, Min Hu, Shuli Liu, Jing Ling, Yanbin Kuang, Tuo Zhang, Siwei Zhang, Feng Yao, Binhua P Zhou, Jiong Deng （Affiliations 1 Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2 Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 3 Translational Medical Research Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. 4 Department of Pathology, Kunming Medical University, Kunming, Yunnan, China. 5 Department of Oral and Maxillofacial-Head and Neck Oncology, the Ninth People\'s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 6 Department of Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 7 Department of Respiratory Medicine, The Second Affiliated Hospital, Dalian Medical University, Dalian, China. 8 Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. 9 Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. yaofeng6796678@126.com. 10 Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, USA. peter.zhou@uky.edu. 11 Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. jiongdeng@shsmu.edu.cn. 12 Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China. jiongdeng@shsmu.edu.cn. 13 Translational Medical Research Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. jiongdeng@shsmu.edu.cn.）
出处： Oncogene 2020 Vol.39 No.15 P3179-3194
摘要： Chronic inflammation has been linked to promotion of tumorigenesis and metastasis in lung. However, due to lack of a relevant animal model for charact ...
作者： Ruizhi Hu;Zhixin Chen;Chen Dai;Xiang Guo;Wei Feng;Zhuang Liu;Han Lin;Yu Chen;Wu Rong （f Department of Orthopedics, The Second Affiliated Hospital, The Navy Medical University, Shanghai, 200003, China e Department of Ultrasound in Medicine, Shanghai East Hospital, Tongji University, Shanghai, 200120, China g Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China b Department of Ultrasound in Medicine, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200080, China a Department of Ultrasound in Medicine, Shanghai Tenth People\'s Hospital, Tongji University, Shanghai, 200072, China d State Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China c School of Life Sciences, Shanghai University, Shanghai, 200444, China）
出处： Biomaterials 2020 P120455
关键词： Silicene;Radiotherapy;Photothermal therapy;Nanomedicine;Cancer
摘要： The rapid development of nanotechnology has triggered the emerging of tremendous theranostic nanoplatforms for combating cancers. Silicene, as an emer ...
作者： Yangbai Sun PhD;Renpeng Zhou PhD;Hao Zhang MD;Liu Rong MD;Wang Zhou PhD;Yimin Liang PhD;Qingfeng Li MD （6 Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing, 100084, China 5 Department of Intensive Care Unit, Wuhan Leishenshan Hospital, Wuhan, 430101, China 7 Qiu-Jiang Bioinformatics Institute, Shanghai, 200003, China 2 null 1 Department of Musculoskeletal Surgery, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, China 4 Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China 3 Department of Bone Tumor Surgery, Changzheng Hospital of Second Military Medical University, Shanghai, 200003, China）
出处： Journal of the American Academy of Dermatology 2020
作者： Wenzheng Guo, Kaimi Li, Beibei Sun, Dongliang Xu, Lingfeng Tong, Huijing Yin, Yueling Liao, Hongyong Song, Tong Wang, Bo Jing, Min Hu, Shuli Liu, Yanbin Kuang, Jing Ling, Qi Li, Yadi Wu, Qi Wang, Feng Yao, Binhua P Zhou, Shu-Hai Lin, Jiong Deng （Affiliations 1 Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine. 2 Shanghai Jiao Tong University. 3 Translation Medicine Center, Shanghai Chest Hospital, Shanghai Jiao Tong University. 4 Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine. 5 Pathophysiology, Shanghai Jiao Tong University School of Medicine. 6 Oncology, Fudan University Shanghai Cancer Center. 7 Department of Pathophysiology, Key laboratory of Cell Differentiation and Apoptosis of Minister of Education, Shanghai Jiao Tong University School of Medicine. 8 Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People\'s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. 9 Department of Respiratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University. 10 Department of Oncology, Shanghai General Hospital, Shanghai Jiaotong University. 11 University of Kentucky Medical Center. 12 Respiratory Medicine, Second Affiliated Hospital of Dalian Medical University. 13 Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai. 14 Molecular and Cellular Biochemistry, University of Kentucky School of Medicine. 15 State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University. 16 Pathophysiology, Shanghai Jiao Tong University School of Medicine jiongdeng@shsmu.edu.cn.）
出处： Cancer research 2020
摘要： Cancer cells need to generate large amounts of glutathione (GSH) to buffer oxidative stress during tumor development. A rate-limiting step for GSH bio ...
作者： Fang Wu, Feng Wang, Qian Yang, Yawen Zhang, Ke Cai, Lian Liu, Shuchun Li, YuanZheng Zheng, Jialing Zhang, Yiting Gui, Youhua Wang, Xu Wang, Yonghao Gui, Qiang Li （Affiliations 1 Translational Medical Center for Development and Disease, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect, Children\'s Hospital of Fudan University, Shanghai, 201102, China. 2 Cardiovascular Center, Children\'s Hospital of Fudan University, Shanghai, 201102, China. 3 Department of Neonatology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. 4 Department of Emergency, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. 5 Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China. 6 Cancer Metabolism Laboratory, Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, 200032, China. 7 Cardiovascular Center, Children\'s Hospital of Fudan University, Shanghai, 201102, China. yhgui@shmu.edu.cn. 8 Translational Medical Center for Development and Disease, Institute of Pediatrics, Shanghai Key Laboratory of Birth Defect, Children\'s Hospital of Fudan University, Shanghai, 201102, China. liq@fudan.edu.cn.）
出处： In vitro cellular & developmental biology. Animal 2020
关键词： Apoptosis;H9c2;Hyperglycemia;Myocardial injury;Proliferation;miRNA-23a-3p.
摘要： Maternal hyperglycemia potentially inhibits the development of the fetal heart by suppressing cardiomyocyte proliferation and promoting apoptosis. Dif ...
